[go: up one dir, main page]

WO2025186588A1 - Composition comprising sideritis derivatives and olive derivatives for memory enhancement - Google Patents

Composition comprising sideritis derivatives and olive derivatives for memory enhancement

Info

Publication number
WO2025186588A1
WO2025186588A1 PCT/GR2025/000004 GR2025000004W WO2025186588A1 WO 2025186588 A1 WO2025186588 A1 WO 2025186588A1 GR 2025000004 W GR2025000004 W GR 2025000004W WO 2025186588 A1 WO2025186588 A1 WO 2025186588A1
Authority
WO
WIPO (PCT)
Prior art keywords
sideritis
derivatives
olive
composition according
tea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/GR2025/000004
Other languages
French (fr)
Other versions
WO2025186588A8 (en
Inventor
Ioulia Tseti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2025186588A1 publication Critical patent/WO2025186588A1/en
Publication of WO2025186588A8 publication Critical patent/WO2025186588A8/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Definitions

  • compositions for oral administration, for memory enhancement which comprise one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa avd one or more olive derivatives (Olea europaea).
  • tea derivatives preferably derivatives of sideritis tea (Sideritis spp.)
  • Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa avd one or more olive derivatives (Olea europaea).
  • Hydroxytyrosol can be extracted from olive leaves and fruit and is a molecule with antioxidant, anti-inflammatory, antiatherogenic and antithrombotic properties. In vitro studies show that, in addition to its antioxidant activity, it can improve endothelial dysfunction, lipid profile and has anti-inflammatory properties. It can therefore be considered as a neuroprotective, cardioprotective and chemoprotective agent [Bertelli M, Kiani AK, Paolacci S, Manara E, Kurti D, Dhuli K, Bushati V, Miertus J, Pangallo D, Baglivo M, Beccari T, Michelin! S. Hydroxytyrosol: A natural compound with promising pharmacological activities. J Biotechnol.
  • Hydroxytyrosol has also been considered as an antithrombotic agent, since it reduces endothelial cell activation, significantly reducing platelet aggregation, which is one of the stages of thrombus formation [DelTAgli M, et al. Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase. Br J Nutr. 2008; 99(5): 945-51].
  • Document EP2608798B1 relates to an extract from aerial plant parts of Sideritis sp. for use in improving cognitive performance, wherein said aerial plant parts are fresh or dried plant parts selected from the group Sideritis euboa, Sideritis scardica, Sideritis raised or mixtures thereof.
  • Document EP2515922B1 relates to siderite extracts obtained by extraction with water or aqueous-alcoholic solvents for use in the treatment or prevention of neurodegenerative diseases, wherein said neurodegenerative disease is associated with aggregated proteins/peptides, including Alzheimer’s disease.
  • APP amyloid precursor protein
  • sideritis extract is also present in commercial products, e.g. Powerhealth® effervescent tablets with lOOmg sideritis extract, being available in the Greek market.
  • Document CN106138016A refers to the use of hydroxytyrosol for the prevention and treatment of Alzheimer’s disease. When administered to mice suffering from Alzheimer's disease, hydroxytyrosol was found to be able to cross the blood-brain barrier to remarkably improve the functions of cerebral nerves, as well as learning and memory abilities.
  • compositions comprising the combination of tea derivatives and olive derivatives, nor their use in enhancing memory.
  • compositions with even more intense ability of memory enhancement and simultaneous action on cardiometabolic diseases, with even more intense antioxidant action against the oxidation of LDL cholesterol, as well as against atherosclerosis.
  • the present invention taking into account all the aforementioned data, solves ail the above problems of the state of the art, and indeed with unexpectedly advantages and better results in terms of enhancing the mental function of individuals and treating symptoms related to dementia, especially in the elderly, enhancing memory and treating symptoms related to memory' loss in patients with Alzheimer's Disease, while exerting a simultaneous cardioprotective effect, taking advantage of the synergistic, as found, action of tea and olive derivatives, both in enhancing memory and cardioprotection,
  • the present invention is defined by the following:
  • Composition for oral administration which comprises one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoliata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Olea europaea).
  • tea derivatives preferably derivatives of sideritis tea (Sideritis spp.)
  • olive derivatives Olea europaea
  • composition according to definition 1 which is formulated in granules for oral suspension or granules for immediate ingestion or tablets or soft capsules or hard capsules or oral solutions or oral suspensions or syrups or powders, preferably soft capsules or hard capsules.
  • definition 3 Composition according to any of the definitions 1 to 2, wherein the tea derivative is a tea extract of Sideritis spp., said extract ranges preferably from 1 to 1000 mg per formulation, more preferably is at 100 mg or at 500 mg per formulation.
  • Definition 4 Composition according to definition 3, wherein the tea extract of Sideritis spp.
  • composition is derived from Sideritis scardica, said extract comprises flanonoids in a concentration range from 0,1 to 10 %, preferably at 2,95 % and acteoside in a concentration range from 0,1 to 10 %, preferably at 1,38 %.
  • Definition 5 Composition according to any of the definitions 1 to 4, wherein the olive derivative is an olive extract and/or solid hydroxytyrosol in concentration range from 0,2% to 6% per formulation and/or one or more additional substances derived from the olive, preferably oleuropein and/or oleocanthal.
  • Definition 6 Composition according to definition 5, wherein said olive extract is derived from olive fruit and/or from olive leaves and said extract comprises hydroxy tyrosol in a concentration range from 0,2% to 6% per formulation.
  • Definition 8 Composition according to any of the definitions 1 to 7, which additionally comprises one or more honey derivatives.
  • Definition 9 Composition according to any of the definitions 1 to 8, which additionally comprises one or more excipients, including one or more diluents and/or one or more lubricants and/or one or more anti-caking agents and/or one or more flavor enhancers and/or one or more sweeteners and/or one or more binders and/or one or more disintegrants and/or one or more surfactants.
  • Definition 10 Composition according to any of the definitions 1 to 9, for use in enhancing the mentai function, treating symptoms related to dementia, especially in the elderly, enhancing memory and treating symptoms related to memory loss in patients with Alzheimer's Disease.
  • Nutritional supplement comprising the composition according to any of the definitions 1 to 10. It was surprisingly found that the specific composition of the present invention, comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea ⁇ Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Oiea europaea) exhibits significantly more intense results in terms of enhancing the mental function of individuals and treating symptoms related to dementia, especially in the elderly, compared to corresponding compositions comprising only tea derivatives or only olive derivatives.
  • tea derivatives preferably derivatives of sideritis tea ⁇ Sideritis spp.
  • the specific composition of the present invention comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea ⁇ Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Oiea europaea) exhibits a significantly more enhancing effect specifically for memory enhancement, compared to corresponding compositions comprising only tea derivatives or only olive derivatives.
  • tea derivatives preferably derivatives of sideritis tea ⁇ Sideritis spp.
  • the specific composition of the present invention comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea ⁇ Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa and one or more oiive derivatives (O/ea europaea) exhibits significantly extended treatment of symptoms related to memory loss specifically in patients with Alzheimer's Disease, compared to corresponding compositions comprising only tea derivatives or only olive derivatives.
  • tea derivatives preferably derivatives of sideritis tea ⁇ Sideritis spp.
  • one or more oiive derivatives O/ea europaea
  • the specific composition of the present invention comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp. ⁇ more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoliata acdrir Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Olea europaea) exhibits significantly more enhanced antioxidant activity against LDL cholesterol oxidation and cardioprotection, compared to corresponding compositions comprising only tea derivatives or only olive derivatives.
  • the specific composition of the present invention comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp. ⁇ , more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoliata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Olea europaea) presents unexpectedly better results in simultaneously enhancing the mental function of individuals and treating symptoms related to dementia, especially in the elderly, enhancing memory and treating symptoms related to memory loss in patients with Alzheimer's disease and with simultaneous cardioprotective effect.
  • tea derivatives preferably derivatives of sideritis tea
  • Sideritis tea preferably derivatives of sideritis tea
  • Sideritis spp. ⁇ more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoliata and/or Sideritis raeseri and/or
  • compositions of the present invention can be prepared by methods already known In the state of art.
  • Example 1 In a preferred embodiment the composition of the present invention comprises the following:
  • composition of the Example 1 is formulated into soft capsules.
  • the composition of the present Example 1 exhibits ali the advantages of the present invention mentioned above.
  • composition of the present Example 1 comprising both sideritis derivatives and olive derivatives was compared with the same composition comprising either only olive derivatives in the same quantities and without sideritis derivatives or only sideritis derivatives in the same quantities and without olive derivatives and it was found that the composition of the above Example 1 exhibits more improved properties than by receiving simultaneously the two compositions with individual olive derivatives and individual sideritis derivatives.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The present invention relates to compositions for oral administration, for memory enhancement, which comprise one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoliate and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Olea europaea).

Description

COMPOSITION COMPRISING SIDERITIS DERIVATIVES AND OLIVE DERIVATIVES FOR MEMORY ENHANCEMENT
Description of the invention The present invention relates to compositions for oral administration, for memory enhancement, which comprise one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa avd one or more olive derivatives (Olea europaea).
Sideritis tea is full of flavonoids, polyphenols, phenolic acids, glycosides, resulting in beneficial effects on the intestinal microbiome, the digestive system, the prevention of insulin resistance and hyperlipidemia, helping to alleviate the common consequences of overweight and obesity, exerting a beneficial effect on lipid parameters and cardiovascular risk factors, as well as a positive effect on improving memory and mood, especially in elder adults [Dorota Zyzelewicz, Kamila Kuibat-Warycha, Joanna Oracz, and Kacper Zyzelewicz. 2020. "Polyphenols and Other Bioactive Compounds of Sideritis Plants and Their Potential Biological Activity” Molecules 25, no. 16: 3763],
Hydroxytyrosol can be extracted from olive leaves and fruit and is a molecule with antioxidant, anti-inflammatory, antiatherogenic and antithrombotic properties. In vitro studies show that, in addition to its antioxidant activity, it can improve endothelial dysfunction, lipid profile and has anti-inflammatory properties. It can therefore be considered as a neuroprotective, cardioprotective and chemoprotective agent [Bertelli M, Kiani AK, Paolacci S, Manara E, Kurti D, Dhuli K, Bushati V, Miertus J, Pangallo D, Baglivo M, Beccari T, Michelin! S. Hydroxytyrosol: A natural compound with promising pharmacological activities. J Biotechnol. 2020; 309: 29-33]. Hydroxytyrosol has also been considered as an antithrombotic agent, since it reduces endothelial cell activation, significantly reducing platelet aggregation, which is one of the stages of thrombus formation [DelTAgli M, et al. Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase. Br J Nutr. 2008; 99(5): 945-51]. Document EP2608798B1 relates to an extract from aerial plant parts of Sideritis ssp. for use in improving cognitive performance, wherein said aerial plant parts are fresh or dried plant parts selected from the group Sideritis euboa, Sideritis scardica, Sideritis raised or mixtures thereof. Document EP2515922B1 relates to siderite extracts obtained by extraction with water or aqueous-alcoholic solvents for use in the treatment or prevention of neurodegenerative diseases, wherein said neurodegenerative disease is associated with aggregated proteins/peptides, including Alzheimer’s disease.
In the study of Hofrichter et al., 2.016 [Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Pahnke J. Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer’s p-Amyioidosis Mouse Models and Aged C57BI/6 Mice. J Alzheimers Dis. 2016; 53(3): 967-80] it was found that daily oral treatment with extracts of Sideritis spp. {Sideritis euboea and Sideritis scardica} significantly enhanced cognitive performance in aged, non-transgenic, as well as in transgenic mice with amyloid precursor protein (APP), an effect that was even more pronounced when the extracts of both species were applied in combination.
In the study of Moussavi et al., 2022 [Moussavi N, Azizullah H, Malterud KE, Inngjerdingen KT, Wangensteen H. Immunomodulating polyphenols from Sideritis scardica. Journal of Functional Foods, 2022; 96: 105197] it is reported that S’, scardica comprises a pool of compounds that indicate multifaceted activities according to the results of various in vitro bioassays and therefore may serve as a potential candidate for adjunctive treatment of Alzheimer's disease.
It is noteworthy that sideritis extract is also present in commercial products, e.g. Powerhealth® effervescent tablets with lOOmg sideritis extract, being available in the Greek market.
Document CN106138016A refers to the use of hydroxytyrosol for the prevention and treatment of Alzheimer’s disease. When administered to mice suffering from Alzheimer's disease, hydroxytyrosol was found to be able to cross the blood-brain barrier to remarkably improve the functions of cerebral nerves, as well as learning and memory abilities. However, in the prior art, there are no mentions yet of compositions comprising the combination of tea derivatives and olive derivatives, nor their use in enhancing memory.
Despite of the positive properties of the isolated components mentioned above, there is a continuous need for compositions with even more intense ability of memory enhancement and simultaneous action on cardiometabolic diseases, with even more intense antioxidant action against the oxidation of LDL cholesterol, as well as against atherosclerosis.
The present invention, taking into account all the aforementioned data, solves ail the above problems of the state of the art, and indeed with unexpectedly advantages and better results in terms of enhancing the mental function of individuals and treating symptoms related to dementia, especially in the elderly, enhancing memory and treating symptoms related to memory' loss in patients with Alzheimer's Disease, while exerting a simultaneous cardioprotective effect, taking advantage of the synergistic, as found, action of tea and olive derivatives, both in enhancing memory and cardioprotection,
More specifically, the present invention is defined by the following:
Definition 1, Composition for oral administration, which comprises one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoliata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Olea europaea).
Definition 2. Composition according to definition 1, which is formulated in granules for oral suspension or granules for immediate ingestion or tablets or soft capsules or hard capsules or oral solutions or oral suspensions or syrups or powders, preferably soft capsules or hard capsules. Definition 3. Composition according to any of the definitions 1 to 2, wherein the tea derivative is a tea extract of Sideritis spp., said extract ranges preferably from 1 to 1000 mg per formulation, more preferably is at 100 mg or at 500 mg per formulation. Definition 4. Composition according to definition 3, wherein the tea extract of Sideritis spp. is derived from Sideritis scardica, said extract comprises flanonoids in a concentration range from 0,1 to 10 %, preferably at 2,95 % and acteoside in a concentration range from 0,1 to 10 %, preferably at 1,38 %. Definition 5, Composition according to any of the definitions 1 to 4, wherein the olive derivative is an olive extract and/or solid hydroxytyrosol in concentration range from 0,2% to 6% per formulation and/or one or more additional substances derived from the olive, preferably oleuropein and/or oleocanthal. Definition 6. Composition according to definition 5, wherein said olive extract is derived from olive fruit and/or from olive leaves and said extract comprises hydroxy tyrosol in a concentration range from 0,2% to 6% per formulation.
Definition 7. Composition according to any of the definitions 1 to 6, which comprises hydroxytyrosol at a range from 0,5 to 10 mg per formulation, preferably comprises 2,5 or 5 mg hydroxytyrosol per formulation.
Definition 8. Composition according to any of the definitions 1 to 7, which additionally comprises one or more honey derivatives.
Definition 9. Composition according to any of the definitions 1 to 8, which additionally comprises one or more excipients, including one or more diluents and/or one or more lubricants and/or one or more anti-caking agents and/or one or more flavor enhancers and/or one or more sweeteners and/or one or more binders and/or one or more disintegrants and/or one or more surfactants. Definition 10. Composition according to any of the definitions 1 to 9, for use in enhancing the mentai function, treating symptoms related to dementia, especially in the elderly, enhancing memory and treating symptoms related to memory loss in patients with Alzheimer's Disease.
Definition 11. Nutritional supplement comprising the composition according to any of the definitions 1 to 10. It was surprisingly found that the specific composition of the present invention, comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea {Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Oiea europaea) exhibits significantly more intense results in terms of enhancing the mental function of individuals and treating symptoms related to dementia, especially in the elderly, compared to corresponding compositions comprising only tea derivatives or only olive derivatives.
Furthermore, it was surprisingly found that the specific composition of the present invention comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea {Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Oiea europaea) exhibits a significantly more enhancing effect specifically for memory enhancement, compared to corresponding compositions comprising only tea derivatives or only olive derivatives. It was surprisingly found that the specific composition of the present invention, comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea {Sideritis spp.), more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa and one or more oiive derivatives (O/ea europaea) exhibits significantly extended treatment of symptoms related to memory loss specifically in patients with Alzheimer's Disease, compared to corresponding compositions comprising only tea derivatives or only olive derivatives. In addition, it was surprisingly found that the specific composition of the present invention comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp.\ more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoliata acdrir Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Olea europaea) exhibits significantly more enhanced antioxidant activity against LDL cholesterol oxidation and cardioprotection, compared to corresponding compositions comprising only tea derivatives or only olive derivatives.
Furthermore, it was surprisingly found that the specific composition of the present invention comprising the combination with one or more tea derivatives, preferably derivatives of sideritis tea (Sideritis spp.}, more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoliata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives (Olea europaea) presents unexpectedly better results in simultaneously enhancing the mental function of individuals and treating symptoms related to dementia, especially in the elderly, enhancing memory and treating symptoms related to memory loss in patients with Alzheimer's disease and with simultaneous cardioprotective effect.
Moreover, all the above advantages, specifically the addressing of memory problems and Alzheimer's disease memory consequences with the simultaneous cardioprotective effect, were observed to exhibit synergy at a much greater intensity than the person skilled in the art would expect, when combining sideritis derivatives on the one hand and olive derivatives on the other.
Finally, it was surprisingly found that the more is restricted the scope of the claims, the more intense are the effects and the advantages of the present invention.
The compositions of the present invention can be prepared by methods already known In the state of art.
The present invention is further described by the following indicative, but non-limiting example. Example 1: In a preferred embodiment the composition of the present invention comprises the following:
The composition of the Example 1 is formulated into soft capsules. The composition of the present Example 1 exhibits ali the advantages of the present invention mentioned above.
In fact, the composition of the present Example 1 comprising both sideritis derivatives and olive derivatives was compared with the same composition comprising either only olive derivatives in the same quantities and without sideritis derivatives or only sideritis derivatives in the same quantities and without olive derivatives and it was found that the composition of the above Example 1 exhibits more improved properties than by receiving simultaneously the two compositions with individual olive derivatives and individual sideritis derivatives.

Claims

Claims
1. Composition for oral administration, which comprises one or more tea derivatives, preferably derivatives of siderite tea (Sideritis spp.}, more preferably derivatives of Sideritis syriaca and/or Sideritis scardica and/or Sideritis perfoiiata and/or Sideritis raeseri and/or Sideritis euboa and one or more olive derivatives [Gies europaea}.
2. Composition according to claim 1, which is formulated in granules for orai suspension or granules for immediate ingestion or tablets or soft capsules or hard capsules or oral solutions or oral suspensions or syrups or powders, preferably soft capsules or hard capsules.
3. Composition according to any of the claims 1 to 2, wherein the tea derivative is a tea extract of Sideritis spp., said extract ranges preferably from 1 to 1000 mg per formulation, more preferably is at 100 mg or at 500 mg per formulation.
4. Composition according to claim 3, wherein the tea extract of Sideritis spp, is derived from Sideritis scardica, said extract comprises flanonoids in a concentration range from 0,1 to 10 %, preferably at 2,95 % and acteoside in a concentration range from 0,1 to 10 %, preferably at 1,38 %.
5. Composition according to any of the claims 1 to 4, wherein the olive derivative is an olive extract and/or solid hydroxytyrosol in concentration range from 0,2% to 6% per formulation and/or one or more additional substances derived from the olive, preferably oleuropein and/or oleocanthal.
6. Composition according to claim 5, wherein said olive extract is derived from olive fruit and/or from olive leaves and said extract comprises hydroxytyrosol in a concentration range from 0,2% to 6% per formulation.
7. Composition according to any of the claims 1 to 6, which comprises hydroxytyrosol at a range from 0,5 to 10 mg per formulation, preferably comprises 2,5 or 5 mg hydroxytyrosol per formulation,
8. Composition according to any of the claims 1 to 7, which additionally comprises one or more honey derivatives.
9. Composition according to any of the claims 1 to 8, which additionally comprises one or more excipients, including one or more diluents and/or one or more lubricants and/or one or more anti-caking agents and/or one or more flavor enhancers and/or one or more sweeteners and/or one or more binders and/or one or more disintegrants and/or one or more surfactants,
10. Composition according to any of the claims 1 to 9, for use in enhancing the mental function, treating symptoms related to dementia, especially in the elderly, enhancing memory and treating symptoms related to memory loss in patients with Alzheimer's Disease.
11. Nutritional supplement comprising the composition according to any of the claims 1 to 10.
PCT/GR2025/000004 2024-03-04 2025-03-04 Composition comprising sideritis derivatives and olive derivatives for memory enhancement Pending WO2025186588A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20240100153 2024-03-04
GR20240100153A GR1010953B (en) 2024-03-04 2024-03-04 Composition based on tea and olive oil derivatives for memory enhancement

Publications (2)

Publication Number Publication Date
WO2025186588A1 true WO2025186588A1 (en) 2025-09-12
WO2025186588A8 WO2025186588A8 (en) 2025-10-30

Family

ID=95309807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GR2025/000004 Pending WO2025186588A1 (en) 2024-03-04 2025-03-04 Composition comprising sideritis derivatives and olive derivatives for memory enhancement

Country Status (2)

Country Link
GR (1) GR1010953B (en)
WO (1) WO2025186588A1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130156707A1 (en) * 2010-08-27 2013-06-20 Finzelberg Gmbh & Co. Kg Plant extracts made of sideritis and use thereof to boost cognitive performance
EP2515922B1 (en) 2009-12-23 2013-10-02 Finzelberg GmbH & Co. KG Plant extract for treating neurodegenerative illnesses
CN104171025A (en) * 2014-08-15 2014-12-03 湖北省金贝嘉天然农业股份有限公司 Selenium-rich edible oil suitable for women and children
WO2015060794A1 (en) * 2013-10-25 2015-04-30 Nbv Ilaç Doğal Ted. Ürün Koz. Gida Ve Mad. Paz. San.Tic. Ltd. Şti. Combination of olive oil, nigella sativa seed oil and rosemary oil
CN104782792A (en) * 2015-04-15 2015-07-22 浙江久晟茶业发展有限公司 Omega health edible oil prepared from camellia oil and preparation method for omega health edible oil
CN106138016A (en) 2016-06-28 2016-11-23 西安交通大学 Hydroxytyrosol application in the medicine of preparation preventing and treating Alzheimer
CN115282216A (en) * 2022-09-15 2022-11-04 中国科学院兰州化学物理研究所 Composition with potential Alzheimer disease prevention and treatment functions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2515922B1 (en) 2009-12-23 2013-10-02 Finzelberg GmbH & Co. KG Plant extract for treating neurodegenerative illnesses
US20130156707A1 (en) * 2010-08-27 2013-06-20 Finzelberg Gmbh & Co. Kg Plant extracts made of sideritis and use thereof to boost cognitive performance
EP2608798B1 (en) 2010-08-27 2015-03-04 Finzelberg GmbH & Co. KG Plant extracts made of sideritis and use thereof to boost cognitive performance
WO2015060794A1 (en) * 2013-10-25 2015-04-30 Nbv Ilaç Doğal Ted. Ürün Koz. Gida Ve Mad. Paz. San.Tic. Ltd. Şti. Combination of olive oil, nigella sativa seed oil and rosemary oil
CN104171025A (en) * 2014-08-15 2014-12-03 湖北省金贝嘉天然农业股份有限公司 Selenium-rich edible oil suitable for women and children
CN104782792A (en) * 2015-04-15 2015-07-22 浙江久晟茶业发展有限公司 Omega health edible oil prepared from camellia oil and preparation method for omega health edible oil
CN106138016A (en) 2016-06-28 2016-11-23 西安交通大学 Hydroxytyrosol application in the medicine of preparation preventing and treating Alzheimer
CN115282216A (en) * 2022-09-15 2022-11-04 中国科学院兰州化学物理研究所 Composition with potential Alzheimer disease prevention and treatment functions

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BERTELLI MKIANI AKPAOLACCI SMANARA EKURTI DDHULI KBUSHATI VMIERTUS JPANGALLO DBAGLIVO M: "Hydroxytyrosol: A natural compound with promising pharmacological activities", BIOTECHNOL, vol. 309, 2020, pages 29 - 33, XP085987384, DOI: 10.1016/j.jbiotec.2019.12.016
DELL'AGLI M ET AL.: "Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase", BR J NUTR., vol. 99, no. 5, 2008, pages 945 - 51
DOROTA ZYZELEWICZKAMILA KULBAT-WARYCHAJOANNA ORACZKACPER ZYZELEWICZ: "Polyphenols and Other Bioactive Compounds of Sider tis Plants and Their Potential Biological Activity", MOLECULES, vol. 25, no. 16, 2020, pages 3763
HOFRICHTER JKROHN MSCHUMACHER TLANGE CFEISTEL BWALBROEL BPAHNKE J.: "Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice", J ALZHEIMERS DIS., vol. 53, no. 3, 2016, pages 967 - 80
KOKRAS NIKOLAOS ET AL: "Behavioral and Neurochemical Effects of Extra Virgin Olive Oil Total Phenolic Content and Sideritis Extract in Female Mice", MOLECULES, vol. 25, no. 21, 28 October 2020 (2020-10-28), CH, pages 5000, XP093288626, ISSN: 1420-3049, DOI: 10.3390/molecules25215000 *
MOUSSAVI NAZIZULLAH HMALTERUD KEINNGJERD'INGEN KTWANGENSTEEN H: "Immunomodulating polyphenols from Sideritis scardica", JOURNAL OF FUNCTIONAL FOODS, vol. 96, 2022, pages 105197, XP087167626, DOI: 10.1016/j.jff.2022.105197
SARBISHEGI MARYAM: "Antioxidant Effects of Olive Leaf Extract in Prevention of Alzheimer's Disease and Parkinson's Disease", GENE, CELL AND TISSUE, vol. In Press, no. In Press, 20 January 2018 (2018-01-20), XP093288677, ISSN: 2345-6841, Retrieved from the Internet <URL:https://brieflands.com/articles/gct-79847.pdf> DOI: 10.5812/gct.79847 *
TANCHEVA LYUBKA ET AL: "Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia", ANTIOXIDANTS, vol. 12, no. 12, 28 November 2023 (2023-11-28), pages 2050, XP093288670, ISSN: 2076-3921, DOI: 10.3390/antiox12122050 *
TIAN XIU-YU ET AL: "A review on the structure and pharmacological activity of phenylethanoid glycosides", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER MASSON, AMSTERDAM, NL, vol. 209, 28 August 2020 (2020-08-28), XP086407089, ISSN: 0223-5234, [retrieved on 20200828], DOI: 10.1016/J.EJMECH.2020.112563 *
WIGHTMAN EMMA L. ET AL: "The Acute and Chronic Cognitive and Cerebral Blood Flow Effects of a Sideritis scardica (Greek Mountain Tea) Extract: A Double Blind, Randomized, Placebo Controlled, Parallel Groups Study in Healthy Humans", NUTRIENTS, vol. 10, no. 8, 24 July 2018 (2018-07-24), CH, pages 955, XP093288674, ISSN: 2072-6643, Retrieved from the Internet <URL:https://pmc.ncbi.nlm.nih.gov/articles/PMC6116054/pdf/nutrients-10-00955.pdf> DOI: 10.3390/nu10080955 *

Also Published As

Publication number Publication date
WO2025186588A8 (en) 2025-10-30
GR1010953B (en) 2025-05-26

Similar Documents

Publication Publication Date Title
Akram et al. Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review
Jan et al. Stinging nettle (Urtica dioica L.): a reservoir of nutrition and bioactive components with great functional potential
Al Snafi Pharmacological and therapeutic importance of a review
JP6909511B2 (en) Composition for improving bone health containing a functional fermented product using oysters
KR101694913B1 (en) Composition for improvement of learning and memory function comprising onion extract or its fraction as effective component
AU2004235702A1 (en) Composition comprising bamboo extract and the compounds isolated therefrom showing treating and preventing activity for inflammatory and blood circulation disease
JP5275251B2 (en) Composition comprising an extract of a combined herb for preventing and treating liver disease
WO2015046486A1 (en) Anti-obesity composition
RU2252029C1 (en) Curative-prophylactic composition including combinations of soybean phospholipid complex and extracts of medicinal plants, and biologically active additive based upon this composition
KR20130020095A (en) Hepatoprotective composition containing stauntonia hexaphylla extract
Halaby et al. Protective and curative effect of garden cress seeds on acute renal failure in male albino rats
KR20120045591A (en) Composition comprising an combined herb extract including rhei radix et rhizoma for treating or preventing cognitive dysfunction
WO2025186588A1 (en) Composition comprising sideritis derivatives and olive derivatives for memory enhancement
Dhanalekshmi et al. An Insight into the Phytochemistry, Traditional Uses, and Pharmacology of Ziziphus spina-christi (L) Willd.(Sidr): An Edible Wild Plant of Arabian Peninsula
JP2018168144A (en) Lipase inhibitors and uses thereof
Lim Moringa oleifera
Cheung et al. Potential of Asian natural products for health in aging
CA2634345A1 (en) Phaseolus vulgaris extracts, their use, and formulations containing them
JP2009242273A (en) Oral composition capable of lowering serum ldl cholesterol level
KR20100002836A (en) COMPOSITION COMPRISING PLANTAGO ASIATICA EXTRACT WHICH CONTAINS INHIBITOR AGANIST AMYLOID beta PEPTIDE-INDUCED OXIDATIVE STRESS
TW202200179A (en) Composition for inhibiting phosphodiesterase 5 activity or improving erectile function by using a plant of the genus Phyllanthus
Chauhan et al. Potentials of berries and pomegranate in management of the neurodegenerative disorders
WO2006090206A1 (en) Improved extracts of psidium guajava l., methods for its obtaining and use for the treatment of gastrointestinal disorders
KR102143968B1 (en) Compositions for for inhibiting of macrophage death by triglycerides comprising extracts of Angelica takeshimana
JP2005104877A (en) Stress relieving agent

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 25717323

Country of ref document: EP

Kind code of ref document: A1