WO2025185024A8 - Docetaxel adiposome formulation, preparationmethod therefor, and use thereof - Google Patents
Docetaxel adiposome formulation, preparationmethod therefor, and use thereofInfo
- Publication number
- WO2025185024A8 WO2025185024A8 PCT/CN2024/103795 CN2024103795W WO2025185024A8 WO 2025185024 A8 WO2025185024 A8 WO 2025185024A8 CN 2024103795 W CN2024103795 W CN 2024103795W WO 2025185024 A8 WO2025185024 A8 WO 2025185024A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- docetaxel
- adiposome
- formulation
- therefor
- preparationmethod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided are a docetaxel adiposome formulation, a preparation method therefor, and use thereof. The docetaxel adiposome formulation comprises a monomolecular phospholipid membrane and docetaxel and a neutral lipid that are wrapped in the monomolecular phospholipid membrane. Targeted modification is further carried out on the surface of the docetaxel adiposome. The adiposome formulation has good bioavailability and safety, and the anti-cancer effect of the formulation is significantly superior to that of a clinically used docetaxel injection.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410251160.7 | 2024-03-05 | ||
| CN202410251160 | 2024-03-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2025185024A1 WO2025185024A1 (en) | 2025-09-12 |
| WO2025185024A8 true WO2025185024A8 (en) | 2025-11-27 |
Family
ID=96989878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2024/103795 Pending WO2025185024A1 (en) | 2024-03-05 | 2024-07-05 | Docetaxel liposome formulation, preparation method therefor, and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2025185024A1 (en) |
-
2024
- 2024-07-05 WO PCT/CN2024/103795 patent/WO2025185024A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025185024A1 (en) | 2025-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
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