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WO2025184480A3 - Antibodies to cell adhesion molecule-related/down-regulated by oncogenes (cdon) and uses thereof - Google Patents

Antibodies to cell adhesion molecule-related/down-regulated by oncogenes (cdon) and uses thereof

Info

Publication number
WO2025184480A3
WO2025184480A3 PCT/US2025/017806 US2025017806W WO2025184480A3 WO 2025184480 A3 WO2025184480 A3 WO 2025184480A3 US 2025017806 W US2025017806 W US 2025017806W WO 2025184480 A3 WO2025184480 A3 WO 2025184480A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdon
oncogenes
regulated
cell adhesion
adhesion molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/017806
Other languages
French (fr)
Other versions
WO2025184480A2 (en
Inventor
Denise C. CONNOLLY
Alana M. O'REILLY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute for Cancer Research
Original Assignee
Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Cancer Research filed Critical Institute for Cancer Research
Publication of WO2025184480A2 publication Critical patent/WO2025184480A2/en
Publication of WO2025184480A3 publication Critical patent/WO2025184480A3/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present disclosure provides antibodies specifically binding N-terminal or C -terminal regions of Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes (CDON) polypeptide, methods of making the same, and methods of treating humans having tumors by administering the antibody.
PCT/US2025/017806 2024-02-29 2025-02-28 Antibodies to cell adhesion molecule-related/down-regulated by oncogenes (cdon) and uses thereof Pending WO2025184480A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463559407P 2024-02-29 2024-02-29
US63/559,407 2024-02-29

Publications (2)

Publication Number Publication Date
WO2025184480A2 WO2025184480A2 (en) 2025-09-04
WO2025184480A3 true WO2025184480A3 (en) 2025-10-02

Family

ID=96922064

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/017806 Pending WO2025184480A2 (en) 2024-02-29 2025-02-28 Antibodies to cell adhesion molecule-related/down-regulated by oncogenes (cdon) and uses thereof

Country Status (1)

Country Link
WO (1) WO2025184480A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007022015A1 (en) * 2005-08-12 2007-02-22 Georgetown University Methods to evaluate amyloid beta-lowering agents using wild-type mice
CN112552406A (en) * 2021-02-24 2021-03-26 吴江近岸蛋白质科技有限公司 Anti-human CD73 antibody
US20220289840A1 (en) * 2019-02-15 2022-09-15 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Antibodies To Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes (CDON) And Uses Thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007022015A1 (en) * 2005-08-12 2007-02-22 Georgetown University Methods to evaluate amyloid beta-lowering agents using wild-type mice
US20220289840A1 (en) * 2019-02-15 2022-09-15 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Antibodies To Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes (CDON) And Uses Thereof
CN112552406A (en) * 2021-02-24 2021-03-26 吴江近岸蛋白质科技有限公司 Anti-human CD73 antibody

Also Published As

Publication number Publication date
WO2025184480A2 (en) 2025-09-04

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