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WO2025172803A1 - Dispositif de détection implantable pour surveiller un anévrisme aortique abdominal - Google Patents

Dispositif de détection implantable pour surveiller un anévrisme aortique abdominal

Info

Publication number
WO2025172803A1
WO2025172803A1 PCT/IB2025/051296 IB2025051296W WO2025172803A1 WO 2025172803 A1 WO2025172803 A1 WO 2025172803A1 IB 2025051296 W IB2025051296 W IB 2025051296W WO 2025172803 A1 WO2025172803 A1 WO 2025172803A1
Authority
WO
WIPO (PCT)
Prior art keywords
circuit board
printed circuit
sensor
electronic control
control unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/IB2025/051296
Other languages
English (en)
Inventor
Giovanni Ugo Francesco BROGGI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovascom Ag
Original Assignee
Innovascom Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH000144/2024A external-priority patent/CH721578A2/it
Application filed by Innovascom Ag filed Critical Innovascom Ag
Publication of WO2025172803A1 publication Critical patent/WO2025172803A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A61B5/02014—Determining aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A61B5/02158—Measuring pressure in heart or blood vessels by means inserted into the body provided with two or more sensor elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/076—Permanent implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6876—Blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225—Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
    • A61B2505/05—Surgical care
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/06—Accessories for medical measuring apparatus
    • A61B2560/063—Devices specially adapted for delivering implantable medical measuring apparatus
    • A61B2560/066—Devices specially adapted for delivering implantable medical measuring apparatus catheters therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/06—Arrangements of multiple sensors of different types
    • A61B2562/063—Arrangements of multiple sensors of different types in a linear array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/164—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted in or on a conformable substrate or carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/166—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted on a specially adapted printed circuit board
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6862—Stents

Definitions

  • the present invention generally concerns the technical field of abdominal aortic aneurysm treatment.
  • the present invention concerns an implantable detection device for monitoring an abdominal aortic aneurysm.
  • Abdominal aortic aneurysm consists in a localized and permanent dilation of the abdominal aorta, characterized by an increase in diameter of at least 50%. This dilation is generally due to a degeneration of the artery wall: the vessel, deprived of its normal elasticity, progressively increases in caliber due to blood pressure pushing.
  • CT computed tomography
  • the abdominal CT exam has the drawback of only having clinical and non-instrumental monitoring of the abdominal aortic aneurysm between one CT and the next. As a result, it is not possible to prevent complication due to a new dilation of the arterial vessel, by to blood rehabilitation with a consequent risk of rupture.
  • implantable detection devices which are coupled to the prosthesis, are also known for monitoring blood pressure and blood flow at an abdominal aortic aneurysm treated with endovascular prosthesis.
  • US patent application n. US2022110710A1 describes a pressure sensor couplable to an endovascular prosthesis, for example a stent, positioned at the mouth of an aneurysm.
  • the pressure sensor communicates wirelessly with an external device and is also supplied wirelessly, therefore eliminating the need of a rechargeable battery.
  • US patent n. US7955268B2 describes a pressure detection system coupled to an endovascular prosthesis, for example a stent, implanted into a blood vessel.
  • the sensor assembly comprises a first pressure sensor coupled to a first end of the stent, a second pressure sensor coupled to a second end of the stent, a rechargeable power supply and a wireless communication device able to communicate with a remote communication device.
  • Main object of the present invention is therefore to provide an implantable detection device for monitoring an abdominal aortic aneurysm able to overcome, or at least limit, the drawbacks related to the implantable detection devices of the known type briefly described above.
  • main object of the present invention is to provide an implantable detection device for monitoring an abdominal aortic aneurysm, configured so that it can be implanted at an aneurysmal sac to be monitored in a simple and quick way.
  • Another object of the present invention is to provide an implantable detection device for monitoring an abdominal aortic aneurysm, configured so as to fit optimally within a catheter used for positioning it within the aneurysmal sac to be monitored.
  • Another object of the present invention is to provide an implantable detection device for monitoring an abdominal aortic aneurysm, configured so as to allow the aneurysmal sac to be monitored at a plurality of regions, spaced from each other.
  • Last, but not least, object of the present invention is to provide an implantable detection device for monitoring an abdominal aortic aneurysm, configured so as to be simple to implement and which can be manufactured at competitive costs.
  • an implantable detection device for monitoring an abdominal aortic aneurysm according to independent claim 1. Further preferential characteristics and aspects of the invention are set out in the dependent claims.
  • the invention therefore concerns an implantable detection device for monitoring an abdominal aortic aneurysm, comprising a printed circuit board, at least one sensor for measuring blood pressure and flow within the abdominal aortic aneurysm and electrically connected to the printed circuit board, and an electronic control unit positioned on the printed circuit board and in electrical communication with the at least one sensor.
  • the implantable detection device is characterized in that the printed circuit board is flexible, so that it can be folded reversibly during implantation of the implantable detection device.
  • the implantable detection device according to the invention can advantageously be implanted in a simple and quick way into the aneurysmal sac to be monitored, without damaging its electrical and electronic components. Moreover, the implantable detection device according to the invention advantageously allows the aneurysmal sac to be monitored at a plurality of regions spaced from each other.
  • the printed circuit board is preferably rectangular in shape with a length ranging from about 80 mm to about 38 mm and a width (W) ranging from about 40 mm to about 14 mm.
  • the device further comprises a radio frequency identification Tag and an antenna, both positioned on the printed circuit board, wherein the radio frequency identification Tag is in electrical communication with the electronic control unit and communicates, through the antenna, with an external unit outside the device.
  • the device further comprises a hardware module, which is positioned on the printed circuit board, acts as an interface between each sensor and the electronic control unit and is configured to convert the signals coming from each sensor into a format understandable by the electronic control unit.
  • a hardware module which is positioned on the printed circuit board, acts as an interface between each sensor and the electronic control unit and is configured to convert the signals coming from each sensor into a format understandable by the electronic control unit.
  • the at least one sensor is a digital sensor and the hardware module comprises an analog multiplexer controlled by the electronic control unit.
  • the at least one sensor is a digital sensor and the hardware module comprises, in addition to the analog multiplexer, an IC module, wherein the analog multiplexer and the IC module are controlled by the electronic control unit.
  • the electronic control unit, the hardware module and the radio frequency identification Tag are arranged at the centre of the printed circuit board, following a fixed rectangular configuration, which extends longitudinally to the printed circuit board.
  • the rectangular configuration preferably has a length 1 equal to approximately 23 mm and a width w equal to about 4 mm.
  • the antenna has the shape of a series of tracks which extend parallel to each other and suitably spaced at a peripheral edge of the printed circuit board.
  • the radio frequency identification Tag comprises a radio frequency communication module, an “Energy Harvesting” module, configured to exploit a magnetic field generated for communication with the external unit, and a memory, preferably an EEPROM memory.
  • the at least one sensor comprises a plurality of sensors, preferably four sensors, which are positioned on a strip of conductive material, which extends longitudinally from the printed circuit board.
  • the at least one sensor comprises four sensors, which are positioned in pairs, outside the printed circuit board, on the opposite side with respect to a transverse axis of the printed circuit board, wherein strips of conductive material extend longitudinally from the printed circuit board, each of which has a pair of branches of conductive material for the electrical connection of a respective sensor.
  • the at least one sensor comprises a plurality of sensors (SI, S2, S3, S4), preferably four sensors, positioned outside the printed circuit board, all on the same side or the four sides of the printed circuit board and connected to it by means of respective strips of conductive material.
  • the at least one sensor comprises a plurality of sensors, preferably four sensors, positioned inside the printed circuit board, which are aligned to each other along a longitudinal axis of the printed circuit board.
  • the device comprises a biocompatible coating preferably constituted by a layer of parylene C.
  • FIG. 1 is a schematic plan view of an implantable detection device for monitoring an abdominal aortic aneurysm according to a first embodiment of the present invention
  • FIG. 2 is a schematic plan view of a printed circuit board of the device of Figure 1 as it switches from a wound configuration (shown on the left) to a flat or unfolded configuration (shown on the right);
  • FIG. 3 is a block diagram which illustrates the different components of the implantable detection device of Figure 1;
  • FIG. 4 schematically shows an embodiment of a hardware module of the implantable detection device of Figure 3;
  • FIG. 5 schematically shows an alternative embodiment of the hardware module of the implantable detection device of Figure 3.
  • FIGS. 6(a) to 6(d) are plan views of alternative embodiments of an implantable detection device for monitoring an abdominal aortic aneurysm according to the present invention.
  • an implantable detection device for monitoring an abdominal aortic aneurysm according to an embodiment of the present invention is depicted therein.
  • the implantable detection device 100 is further configured to detect, with high sensitivity, blood pressure and blood flow data inside the aneurysmal sac and transmit the pressure and flow data detected to the external unit (not shown).
  • the device 100 comprises a preferably flat printed circuit board or PCB 10 and at least one sensor, preferably four sensors SI, S2, S3, S4 for measuring blood pressure and flow within the aneurysmal sac, which are electrically connected to the printed circuit board 10.
  • the sensors SI, S2, S3, S4 are of the “wire-like” type, i.e. floating in the volume to be monitored and constituted by the aneurysmal sac.
  • the sensors SI, S2, S3, S4 are positioned on a thin strip 11 of conductive material, which extends longitudinally from the printed circuit board 10.
  • the sensors SI, S2, S3, S4 can be of the active or passive type and provide pressure readings in absolute values, with an optimal measurement range of 750 mmHg to 1050 mmHg.
  • the active sensors have the advantage of being able to autonomously perform point or also possibly continuous measurements, or anyhow with a certain frequency, without having to involve the patient.
  • They require internal energy storage which consequently increases their size, therefore making their insertion into the aneurysmal sac with the normal endoscopic systems more complex, if not difficult to achieve.
  • Passive sensors are certainly smaller in size, however an external excitation system (power supply and data request) would be necessary to be able to take pressure readings in the aneurysmal sac.
  • Such solution requires the participation of the patient in every monitoring, therefore always psychologically and mentally binding him/her to his/her health state, with possible negative consequences in relation to adherence to treatment if such monitoring should only be performed sporadically.
  • the SI, S2, S3, S4 sensors have a compact structure of a size which preferably does not exceed 3mmx3mmx3mm. Moreover, each sensor SI, S2, S3, S4 has limited power consumption, preferably below 1 mA. This way, the implantable detection device 100 can operate without a battery.
  • the implantable detection device 100 further comprises an electronic control unit 12, for example a microcontroller, a hardware module 13, a radio frequency identification Tag or RFID Tag 14 and an antenna 15, which are positioned on the printed circuit board 10 and electrically connected thereto.
  • an electronic control unit 12 for example a microcontroller
  • a hardware module 13 for example a radio frequency identification Tag or RFID Tag 14
  • an antenna 15 which are positioned on the printed circuit board 10 and electrically connected thereto.
  • the electronic control unit 12, the hardware module 13 and the RFID Tag 14 are arranged at the centre of the printed circuit board 10 following a fixed rectangular configuration, which extends longitudinally to the printed circuit board 10.
  • Such rectangular configuration advantageously allows to prevent mechanical stress, which could occur when winding the printed circuit board 10 during the step of positioning the detection device 100 at the site of interest, and to reduce to the minimum the risk of the electronic control unit 12, the hardware module 13 and the RFID Tag 14 becoming detached from their soldering points.
  • the size of the rectangular configuration according to which the electronic control unit 12, the hardware module 13 and the RFID Tag 14 are arranged preferably is such that the printed circuit board 10 fits optimally inside the positioning catheter of the implantable detection device 100.
  • the rectangular configuration has a length 1 equal to about 23 mm and a width w equal to about 4 mm.
  • the antenna 15 has the shape of a series of tracks 15a, 15b, 15c, which extend, parallel to one another and suitably spaced, at a peripheral edge of the printed circuit board 10.
  • the antenna 15 has impedance aligned with the internal tuning capacitance value of the device (Ctuning) to form a circuit which has a tuning or resonant frequency (/timing) of about 13.56 MHz.
  • the essential equation for the tuning frequency is the following: where Lantenna is the inductance of the antenna 15.
  • the electronic control unit 12 is in electrical communication with the sensors SI, S2, S3, S4. Communication between the electronic control unit 12 and the sensors SI, S2, S3, S4 preferably occurs through the digital I2C protocol, therefore ensuring a stable and effective connection.
  • the electronic control unit 12 is configured to execute software instructions to monitor the sensors SI, S2, S3, S4, process the data, make decisions and manage other hardware devices.
  • the hardware module 13 acts as an interface between the sensors SI, S2, S3, S4 and the electronic control unit 12 and is configured to convert the signals coming the sensors SI, S2, S3, S4 into a format understandable by the electronic control unit 12.
  • the RFID Tag 14 is in electrical communication with the electronic control unit 12 and communicates, through the antenna 15, with the external unit.
  • the RFID Tag 14 is configured to store data, such as serial numbers, identifiers, authentication information and other specific data, and communicates with the external unit without requiring physical contact, by exploiting the RFID (Radio Frequency Identification) technology.
  • the antenna 15 has the task of receiving energy and radio frequency signals, or RF signals, from an external unit, this way triggering the RFID Tag 14.
  • the antenna 15 acts as a bridge between the RFID Tag 14 and the external unit, therefore allowing the communication of the RFID Tag 14 without requiring its own battery.
  • the RFID Tag 14 preferably is an ST25DV NFC Tag/RFID Dynamic Tag IC, characterized by the ability to keep communications at greater distances than conventional NFC (Near Field Communication) Tags.
  • the RFID Tag 14 preferably uses the ISO 15693 communication protocol and operates at the tuning or resonant frequency ( tuning) of the antenna 15.
  • the RFID Tag 14 comprises a radio frequency communication module 141, or RF communication module, an "Energy Harvesting" module 142 configured to exploit a magnetic field generated for communication with the external unit, and a memory 143.
  • the memory 143 preferably is an EEPROM (Electrically Erasable Programmable Read-Only Memory) memory which can be both read and written and which acts as a communication means between the implantable detection device 100 and the external unit.
  • EEPROM Electrically Erasable Programmable Read-Only Memory
  • Such memory is accessible via RF communication with the external unit but it is also possible to access it physically via the electronic control unit 12 by using digital communication protocols, such as I2C.
  • FIG. 13 an embodiment of a hardware module 13, relating to an implantable detection device 100 in which digital sensors SI, S2, S,3, S4, i.e. sensors whose output is already in digital format, are implemented, is shown therein.
  • the hardware module 13 comprises an analog multiplexer 131 controlled by the electronic control unit 12.
  • the analog multiplexer 131 operates as a switch by selecting the sensor SI, S2, S3, S4 to be triggered on the I2C bus at a given moment.
  • the electronic control unit 12 controls the multiplexer 131 and sends, when needing to interact with a given sensor SI, S2, S3, S4, a signal (SEL) to the multiplexer 131 to select the proper communication channel.
  • the multiplexer 131 mainly intervenes on the SDA (Serial Data) channel, routing the SDA signal towards the sensor selected on the I2C bus, while the SCL (Serial Clock) channel is shared by all the sensors SI, S2, S3, S4 connected to the I2C bus.
  • SDA Serial Data
  • SCL Serial Clock
  • FIG. 13 an alternative embodiment of a hardware module 13’, relating to an implantable detection device 100 comprising analog sensors SI, S2, S3, S4 whose signal therefore needs to be converted into digital format, is shown therein.
  • the hardware module 13’ in addition to the multiplexer 131, comprises an IC module 132 also controlled by the electronic control unit 12.
  • the IC module 132 is configured to convert the signals coming from the sensors SI, S2, S3, S4, specifically the capacitances of the sensors SI, S2, S3, S4, into digital signals for the electronic control unit 12.
  • the multiplexer 131 is configured to select one or more sensors SI, S2, S3, S4 from which to acquire data according to the method described above with reference to the embodiment of Figure 4.
  • the implantable detection device 100 is preferably provided with biocompatible coating or encapsulation, which protects the patient from adverse reactions or damage to adjacent tissues, while preserving the operations of the internal unit itself. Moreover, the coating of the internal unit ensures good interaction of the sensitive part of the pressure sensors with the external environment represented by the aneurysmal sac isolated by the prosthesis. This to prevent a degradation of the quality of the intra-aneurysmal pressure measurement.
  • the biocompatible coating is constituted by a thin layer (about 1-2 pm) of parylene C.
  • the sensors SI, S2, S3, S4 are positioned inside the printed circuit board 10, which are aligned to each other along a longitudinal axis of the printed circuit board 10.
  • each sensor SI, S2, S3, S4 is connected to the printed circuit board 10 by means of a respective thin strip 411a, 411b, 411c, 41 Id of conductive material.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Signal Processing (AREA)
  • Psychiatry (AREA)
  • Power Engineering (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

L'invention concerne un dispositif de détection implantable (100) pour surveiller en continu un anévrisme aortique abdominal. Le dispositif comprend une carte de circuit imprimé (10), au moins un capteur (S1, S2, S3, S4) pour mesurer la pression artérielle et l'écoulement à l'intérieur de l'anévrisme aortique abdominal et connecté électriquement à la carte de circuit imprimé (10), et une unité de commande électronique (12) positionnée sur la carte de circuit imprimé (10) et en communication électrique avec l'au moins un capteur (S1, S2, S3, S4). La carte de circuit imprimé (10) est souple, de telle sorte qu'elle peut être pliée de manière réversible, pendant l'implantation du dispositif de détection implantable.
PCT/IB2025/051296 2024-02-12 2025-02-07 Dispositif de détection implantable pour surveiller un anévrisme aortique abdominal Pending WO2025172803A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH000144/2024A CH721578A2 (it) 2024-02-12 2024-02-12 Dispositivo di rilevamento impiantabile per il monitoraggio di un aneurisma aortico addominale
IT202400002845 2024-02-12
IT102024000002845 2024-02-12
CHCH000144/2024 2024-02-12

Publications (1)

Publication Number Publication Date
WO2025172803A1 true WO2025172803A1 (fr) 2025-08-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2025/051296 Pending WO2025172803A1 (fr) 2024-02-12 2025-02-07 Dispositif de détection implantable pour surveiller un anévrisme aortique abdominal

Country Status (1)

Country Link
WO (1) WO2025172803A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044651A1 (fr) * 2014-09-17 2016-03-24 Canary Medical Inc. Dispositifs, systèmes et procédés d'utilisation et de surveillance de dispositifs médicaux
CN105942997A (zh) * 2016-06-06 2016-09-21 任勇 基于腹主动脉支架的综合参数监测装置及其方法
US20220167922A1 (en) * 2019-04-03 2022-06-02 Canary Medical Switzerland Ag Providing medical devices with sensing functionality
WO2024030883A2 (fr) * 2022-08-01 2024-02-08 Qura, Inc. Système implantable de détection de pression cardiovasculaire et procédés d'utilisation
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