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WO2025168752A1 - Dispositif de thermoablation - Google Patents

Dispositif de thermoablation

Info

Publication number
WO2025168752A1
WO2025168752A1 PCT/EP2025/053209 EP2025053209W WO2025168752A1 WO 2025168752 A1 WO2025168752 A1 WO 2025168752A1 EP 2025053209 W EP2025053209 W EP 2025053209W WO 2025168752 A1 WO2025168752 A1 WO 2025168752A1
Authority
WO
WIPO (PCT)
Prior art keywords
applicators
applicator
connectors
energy
control unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2025/053209
Other languages
English (en)
Inventor
Alessia BLUNDO
Fabio ANDREOLA
Giovanni Masotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elesta SpA
Original Assignee
Elesta SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elesta SpA filed Critical Elesta SpA
Publication of WO2025168752A1 publication Critical patent/WO2025168752A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00477—Coupling
    • A61B2017/00482—Coupling with a code
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation

Definitions

  • One of the main advantages of using multiple delivery sources lies in the fact that applicators can be optimally arranged to define a form of ablation generally compatible with the form of the lesion to be treated, whether benign or malignant.
  • Another advantage of multi-source devices with multiple applicators lies in the option of splitting power (and therefore energy) at different points. This is advantageous from the point of view of treatment effectiveness, compared to having a single applicator positioned in the center of the cancer lesion to be removed, or laterally with respect thereto.
  • the treatment with multiple applicators is more homogeneous than the treatment with a single applicator, given that this allows to avoid hot-spots with better energy distribution in the treated volume, that is less energy is needed to perform ablation.
  • the efficiency of the treatment is therefore improved, meaning that the same volume of tissue is treated with less total energy delivered than with a single applicator (single fiber and single source).
  • the object of the present invention is to provide a multiple applicator thermoablation device that tends to reduce or prevent the misuse of a single applicator with repeated repositioning during the treatment.
  • thermoablation device comprising: at least one laser energy source; at least two connectors for respective applicators; and sensors adapted to detect the presence of an applicator connected to each connector.
  • the device further comprises a control unit configured to allow to deliver energy through the applicators only if at least two respective applicators, each of which comprises a respective optical fiber, are connected to said at least two connectors.
  • the number of sources is preferably greater than one and the number of connectors is greater than one, so that each source has at least one connector associated with it.
  • the energy output from each source can be modulated in a different way and independently of that emitted from the other sources. This is useful for adapting the volume impacted by the emitted energy to the shape of the lesion.
  • the use of multiple independent sources, each provided with one or more connectors, is particularly advantageous in the case of laser sources.
  • the same multi-source approach can also be used with other energy sources, for example radio frequency.
  • the number of connectors does not need to be equal to the number of sources.
  • Embodiments described herein prevent the possibility of the operator performing procedures using a single applicator, typically a single optical fiber, in the case of laser devices, and allow the simultaneous use of at least two applicators. From a clinical evaluation, the use of two applicators is a good compromise between cost and effectiveness of treatment. Obviously, even a greater number can be used until the maximum number of applicators allowed in the individual device is reached. Should a cancer lesion be of a size compatible with the use of only one fiber, the additional fiber will not be used and the system will prevent the use of the additional fiber on the next patient (for example, using the multiple insertion technique). To establish the number of applicators to be used for the treatment, there are also available support systems which allow to simulate the insertion of multiple applicators so as to find the optimal position and number, besides the treatment parameters.
  • thermoablation device comprising: at least one laser energy source; a plurality of connectors for respective applicators; a system for detecting the presence of a plurality of optical fiber applicators connected to the respective connectors; a control unit.
  • the method comprises the following steps: receiving, in said control unit, a command to delivery energy towards a plurality of applicators connected to the connectors of the device; verifying, through the control unit, whether respective applicators are connected to at least two of said connectors; enabling the delivery of energy only if respective applicators are connected to the at least two connectors.
  • the thermoablation device 1 further comprises a control unit 15.
  • the control unit may in turn consist of a number of single units linked together in appropriate hierarchical relationships.
  • thermoablation device starts to deliver energy. Otherwise, no energy is emitted and therefore the thermoablation cycle cannot take place.
  • thermoablation device prevents the operator from performing a thermoablation cycle with a single applicator, since both applicators must be placed in the operating position in order for the thermoablation device 1 to start delivering energy.
  • the applicators 7.1, 7.2 may be without data medium 9.1, 9.2 and the connectors 5.1, 5.2 may not be combined with data reading and writing interfaces 11.1, 11.2.
  • thermoablation device 1 comprises more than two sources and/or more than two connectors for as many applicators
  • the energy supply be enabled when the control unit 15 detects the presence of at least two applicators. This ensures that the operator cannot carry out procedures with a single applicator (a single fiber), but without forcing to simultaneously use the maximum number of applicators that device 1 can accept.
  • the thermoablation device 1 comprises more than one connector (at least two) and that the energy delivery can be activated when at least two applicators are connected to at least two (or more) connectors.
  • the thermoablation device 1 uses the reading and writing interfaces 11.1, 11.2 and data media 9.1, 9.2 with which applicators 7.1, 7.2 are provided.
  • the operation in this case is configured so that, when energy has been delivered through an applicator for patient treatment, the applicator becomes unusable for subsequent use, as it is marked as “expired”.
  • This operation can be carried out by the control unit 15 which detects the energy dose delivered through each applicator 7.1, 7.2 and writes on the respective data medium 9.1, 9.2 an indication that the applicator has been used.
  • This data remains stored in the data medium 9.1, 9.2 of the applicator and prevents further use thereof.
  • This operating mode is summarized in the flowchart in Fig.4, where the step of writing the datum relating to the use of the applicator 7.1, 7.2 on the respective data medium 9.1, 9.2 is not explicitly shown. This step can be performed for example at the start of the treatment or at the end of the treatment. When performed at the end of the treatment, the data stored on the chip contained in, or constituting, the data medium 9.1, 9.2 may contain information about the total energy delivered.
  • the control unit 15 stores, in data medium 9.1, 9.2 of each applicator 7.1, 7.2 connected to the thermal ablation device, a code that associates with each other, i.e., mutually pairs the applicators to each other. This allows to prevent the possibility that the operator uses only one applicator 7.1, 7.2 for each procedure, in order to save on consumables, thus bypassing the checks that the control unit 15 performs in order to force the operator to carry out treatments using a multiple applicator.
  • This embodiment performs a check during the use of the thermoablation device, which is summarized in the flowchart in Fig.5.
  • the two checks described above are performed here, i.e., it is checked whether there are as many applicators 7.1, 7.2 as there are connectors 5.1, 5.2, or whether there are at least two connected applicators, and it is further checked whether there has been no previous use of the applicators in any other procedure (i.e. it is checked that the applicators have not expired).
  • the third check is aimed at checking whether the two applicators have the same identification code, or association code, or pairing code, that is they are associated, i.e. paired, to each other.
  • the identification code i.e., the mutual association code, i.e., the mutual pairing of the plurality of applicators to be used simultaneously, is stored by the control unit 15 in the respective data media 9.1, 9.2 by means of the reading and writing interfaces 11.1, 11.2 at an appropriate pre-treatment step, which is not shown in the flowchart of Fig.5.
  • this code can be stored when the applicators 7.1, 7.2 are engaged, i.e., connected to the connectors 5.1, 5.2, or even after checking the presence of applicators and checking whether they have expired.
  • mutual pairing i.e., the mutual association of applicators
  • the identification code i.e., the association or mutual pairing code of the applicators can be the same code for all applicators 7.1, 7.2 connected to the thermoablation device 1 in preparation for a procedure. However, this is not essential. As a matter of fact, it is also possible to associate with each applicator 7.1, 7.2 a specific identification code, different for the two (or more) applicators, and then generate an association, i.e., a pairing between the two or more codes by means of the control unit 15. For example, the control unit can assign to the two applicators 7.1, 7.2 the two codes XX00001 and XX00002 and store in an appropriate memory a record of the fact that these two unique codes identify two applicators paired with each other.
  • identification codes i.e. pairing or association codes
  • the control unit 15 stores the record thereof and is therefore capable of granting or denying consent to deliver energy, after verifying that applicators with the unique codes that the control unit 15 has preliminarily associated, i.e., matched, with each other, are interfaced to the device.
  • each applicator or optical fiber 7.1, 7.2 can take one of three possible conditions: new, used and expired (“EXP”). Each condition is identified by information stored in a data medium, for example a chip with which the applicator is provided.
  • the condition of the specific applicator is changed through interaction with the reading and writing interface 11.1, 11.2 associated with connector 5.1, 5.2 to which the applicator 7.1, 7.2 is connected.
  • the operating mode described below with reference to Figs.6A, 6B, requires that the energy dose delivered through each applicator or optical fiber 7.1, 7.2 is detected by the control unit in particular at an early stage of a treatment cycle.
  • two threshold values of the delivered energy dose are set. These threshold values are labeled Thl and Th2 in the flow chart of Figs.6A, 6B.
  • DoseA and DoseB indicate the energy doses delivered through the two optical fibers or applicators 7.1, 7.2.
  • the threshold values Thl, Th2 are chosen low enough to have no significant therapeutic effect.
  • these two threshold values are used to manage the preliminary stages of the use cycle of the thermoablation device 1, before actual therapeutic treatment, and they have the function of correctly managing the two optical fibers 7.1, 7.2, to ensure that they are always used in combination, and that it is not possible to carry out treatment with one optical fiber and a subsequent treatment with the other.
  • the method summarized in the flowchart of Figs.6A, 6B prevents the operator from circumventing the restriction of always operating with multiple applicators. More precisely, the constraint can be circumvented, but without this allowing the operator to use the second fiber in a subsequent treatment cycle on another patient. In this sense, the method of managing and controlling the device makes it actually useless to circumvent the multi-fiber treatment restriction, since circumventing this restriction does not bring any cost-saving benefits.
  • the expression “PairCode” is used to indicate the identification code, or pairing code, also known as the association code, which mutually associates two applicators 7.1, 7.2 connected and used together and simultaneously for a given treatment.
  • thermoablation device 1 The treatment of the patient requires a preliminary step of setting the thermoablation device 1. This preliminary step requires that the operator to connect an applicator 7.1, 7.2 to each connector 5.1, 5.2. The operator shall then adjust the delivery parameters (in the case of lasers: emission parameters) for each energy source 3.1, 3.2. Basically, these parameters can be the same or different for the two sources.
  • thermoablation device 1 which has more than two sources and/or more than two connectors, using a number of applicators equal to or less than the number of connectors available (but always at least two). Furthermore, as mentioned above, it cannot be ruled out that a source be functionally connected to several connectors and thus configured to supply energy to multiple applicators, although the bi-unique pairing of one source to each connector is preferable, given that it allows easier handling and allows the energy delivered through each applicator to be modulated independently of the other (or the others, if more than two are provided for).
  • the control unit 15 checks the applicators 7.1, 7.2 to verify whether they are present and that their status is consistent with their use in the application cycle just started (or resumed after a standby period). Basically, in this step the control unit 15 checks for the presence of applicators 7.1, 7.2 connected to both connectors 5.1, 5.2 and reads, via the reading and writing interfaces 11.1, 11.2, the data contained in data medium 9.1, 9.2 of each applicator 7.1 and 7.2. These data contain the applicator status, which cannot be expired, i.e, the applicator cannot be marked “EXP” at the start of treatment.
  • a corresponding warning (block 203) is emitted through the human machine interface 17, for example including a display or a monitor. If only one is marked “EXP” but the other is marked “USED” and they are used twinned, that is, they are paired to each other, that is associated with each other, then the treatment can be performed using only the applicator marked “USED”, as clarified hereinafter, see below.
  • thermoablation device 1 if one of the two connectors is without an applicator, the thermoablation device 1 does not proceed any further and requires the connection of the missing applicator (7.1 or 7.2). These two conditions correspond to the first two rows of Table 1. If one of the applicators has expired and the other is new (rows three and four of Table 1), the replacement of the expired applicator is required. In this manner, the device prevents the operator (in order to carry out treatments with only one applicator) from trying to circumvent the multi-applicator treatment restriction by simply always keeping the same applicator (7.1 or 7.2), which remains inactive, connected to one of the two connectors 5.1, 5.2.
  • thermoablation device 1 In the conditions of rows three and four, should the thermoablation device 1 not block the delivery, requiring the replacement of the expired applicator, it would be easy to use the thermoablation device 1 always with only one applicator, while keeping the other applicator always connected but disabled.
  • thermoablation device 1 can proceed with the treatment.
  • These conditions mean that at block 201 an activity is resumed after a standby step, on the same patient (therefore using applicators already previously connected, then marked as used).
  • EXP expired
  • This condition may occur in rare clinical cases where treatment has to be performed with only one applicator.
  • thermoablation device 1 the first time the thermoablation device 1 is used with the new patient, the operator will be required to connect two applicators, even if one of the applicators is not used. This restriction is due to the fact that the device to which only one applicator is connected does not deliver energy (conditions of rows 1 and 2 of Table 1).
  • thermoablation device 1 is started at block 201 (instead of resuming a treatment kept in standby). This means that when the thermoablation device 1 is started at block 201 (instead of resuming a treatment kept in standby), the used applicator condition will never occur, given that the operator must always use new applicators for each new patient. This means that when the thermoablation device 1 is started at block 201 (instead of resuming a treatment kept in standby), the used applicator condition will never occur, given that the operator must always use new applicators for each new patient. This means that when the thermoablation device 1 is started at block 201 (instead of resuming a treatment kept in standby), the used applicator condition will never occur, given that the operator must always use new applicators for each new patient. This means that when the thermoablation device 1 is started at block 201 (instead of resuming a treatment kept in standby), the used applicator condition will never occur, given that the operator must always use new applicators
  • the only conditions that can occur are those of rows 1, 2, 3, 4, 5, and 9.
  • the control unit checks, for each applicator 7.1, 7.2, whether it is marked, i.e., whether both applicators have already been provided with an identification code, i.e., an association code, or pairing code, indicated as “PairCode”. This occurs for any applicator that has already been applied and has already undergone the check steps described below, for example before a standby period of the thermoablation device 1. Applicators with an identification code, i.e., an association code, or pairing code are “paired” and can only work together, that is both must be connected to the thermoablation device 1.
  • thermoablation device 1 may start to deliver energy according to parameters previously set by the operator. For example, the emission is started and stopped using the control through the pedal 19.
  • thermoablation device 1 may be provided with a photodiode or other device sensitive to laser radiation, in front of which there may be placed the distal end of the optical fibers of one and then the other of the optical fibers 7.1, 7.2. Through the control unit 15, the thermoablation device 1 will check whether, upon pressing the pedal 19 and with the distal end of the fiber arranged facing the detector, the latter detects the actual set laser radiation emission.
  • the block 206 checks when the operator releases the pedal 19 thus stopping delivery. When this happens, the system switches to block 207, where the energy dose delivered towards each applicator 7.1, 7.2 is calculated. If the applicators include optical fibers, and each is associated with its own laser source, in this step the control unit 15 calculates the dose emitted by each source 5.1, 5.2. Should the system allow checking and writing simultaneously with delivery, the block 206 may be bypassed and the block 207 may be parallel to block 205. In this case, block 205 and block 219 are merged and the flow of blocks 206 to 218 is simultaneous and parallel to block 205.
  • a second energy threshold Th2 is provided, that is substantially lowre than Thl .
  • the thresholds Thl and Th2 may be respectively equal to approximately 500 Joules and approximately 200 Joules, where these values being provided by way of non-limiting example.
  • block 210 is only reached when at least one of the two emitters 7.1 and 7.2 has emitted a dose of energy greater than Thl.
  • the control unit 15 checks whether the first applicator 7.1 has emitted a dose of energy greater than Thl, that is whether the DoseA dose is equal to or greater than Thl. Should the answer be affirmative, then there arises the need to check whether the second applicator has also emitted a dose greater than Thl, this check being carried out in block 212.
  • the checking procedure switches to block 214, where it is checked whether the applicator 7.2 emitted much less than the applicator 7.1. This is done by comparing the absolute value of the difference between the DoseA and DoseB doses delivered by 7.1 and 7.2 respectively with the second threshold value Th2.
  • the second applicator 7.2 is also marked as “USED”, block 213.
  • the absolute value of this difference be higher than the threshold Th2, it means that the second emitter has not emitted energy or has emitted energy that is significantly lower than the first emitter. This can happen if the emission parameters set are such that they operate with only one emitter. When this happens (positive outcome of the check block 214), the second emitter 7.2 is marked as “EXP” and therefore not usable (anymore), while emitter 7.1 is marked as “USED”, see block 215.
  • thermoablation device comprising: at least one energy source; at least two connectors for respective applicators; sensors adapted to detect the presence of an applicator connected to each connector; a control unit configured to enable energy delivery by the applicators only if at least two respective applicators are connected to said at least two connectors.
  • Clause 2 The device of clause 1, preferably comprising at least two sources and preferably an energy source for each connector.
  • Clause 3 The device of clause 1 or 2, wherein the source or sources are laser sources and wherein the applicators comprise optical fibers.
  • each connector is combined with a presence sensor, interfaced with the control unit and configured to detect the presence of an applicator connected to the respective connector.
  • each connector comprises an interface for reading and writing data in a data medium integrated in each applicator; each interface being functionally connected to the control unit.
  • Clause 7 The device of clause 5 or 6, wherein the control unit is configured to check, for each applicator connected to one of the connectors of the device before delivering energy and through data stored in the data medium of the applicator, whether the applicator has expired and therefore needs to be replaced.
  • Clause 8 The device of clause 5 or 6, wherein the control unit is configured to check, for each applicator connected to a respective connector, before delivering energy and through data stored in a data medium of the applicator, whether the applicator is correct for the chosen application, depending on the behavior parameters set on the device.
  • Clause 9 The device of clause 8, wherein the behavior of the control unit is defined at the time of manufacture, by the service menu, or in remote mode; and wherein the control unit can be configured to change the behavior of the device depending on the data stored in the data medium of the applicator.
  • Clause 10 The device of clause 9, comprising a simulation or planning block adapted to carry out a pretreatment simulation so as to establish the most appropriate parameters depending on the tissue to be treated, in particular one or more of the following: the number of applicators, the type of applicators, the position of the applicators.
  • Clause 11 The device of any one of clauses 5 to 10, wherein the control unit is configured to write, on the data medium of each applicator connected to one of the connectors of the device, an identification code which mutually associates the applicators simultaneously connected with the device; and wherein the control unit is configured to enable energy delivery through at least one of the applicators only if the applicators connected to the device have, stored in the respective data media, identification codes which mutually associate the applicators connected to the device.
  • control unit configured to: identify the presence of applicators connected to the connectors; prevent the use of the device if an insufficient number of applicators are connected to the connectors; check the status of the connected applicators, identifying whether each applicator is new, used or expired; mutually associate the applicators simultaneously connected to the device; enable to perform a treatment using the device if all the following conditions are met:
  • control unit configured to deliver a first dose of energy through the applicators connected to the connectors before mutually associating the applicators.
  • Clause 14 The device of clause 13, wherein the control unit is configured to: mark as used a first applicator connected to the device, through which in a step prior to the mutual association of the applicators, a dose of energy greater than a first threshold was delivered; and mark as expired a second applicator, associated with the first applicator and through which in said step prior to the mutual association a dose of energy smaller than a second threshold was delivered therethrough, or mark said second applicator as used if a dose of energy greater than the second threshold was delivered therethrough.
  • a method for controlling a thermoablation device comprising: at least one energy source; a plurality of connectors for respective applicators; a system for detecting the presence of a plurality of applicators connected to the respective connectors; a control unit; wherein the method comprises the following steps: receiving, in said control unit, a command for delivering energy to a plurality of applicators connected to the connectors of the device; verifying, through the control unit, whether respective applicators are connected to at least two of said connectors; delivering energy only if respective applicators are connected to at least two connectors.
  • Clause 16 The method of clause 15, further comprising the following step: through the control unit and a reading and writing interface combined to each connector, store in a data medium combined with each applicator a connected to a respective connector of the device, an information adapted to prevent a subsequent reuse of the applicator.
  • Clause 17 The method of clause 16, further comprising the step of verifying, through the control unit and the reading and writing interface, whether each applicator connected to the connectors is enabled to be used, before delivering energy through the applicators.
  • Clause 18 The method of clause 15, 16 or 17, further comprising the step of mutually associating the applicators simultaneously connected with the respective connectors by storing mutually associated identification codes on the data media of the applicators through the reading and writing interfaces.
  • Clause 19 The method of clause 18, comprising the steps of: verifying whether all applicators connected to the connectors have mutually associated identification codes; and enabling the energy delivery through the applicators only if the applicators are mutually associated by the respective identification codes.
  • Clause 20 The method of any one of clauses 15 to 19, comprising the following steps: detecting the presence of applicators connected to the connectors; preventing the use of the device if an insufficient number of applicators is connected to the connectors; verifying the status of the connected applicators, detecting if each applicator is new, used or expired; mutually associating the applicators connected simultaneously to the device; allowing to perform a treatment through the device if all the following conditions are met: a sufficient number of applicators are connected to the device; the applicators are mutually associated; and at least one of the applicators is used, or all applicators are new.
  • Clause 21 The method of clause 20, further comprising the step of delivering a first dose of energy through the applicators connected to the connectors before mutually associating the applicators.
  • Clause 22 The method of clause 21, comprising the following steps:

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Le dispositif de thermoablation comprend au moins une source d'énergie, au moins deux connecteurs pour des applicateurs respectifs, des capteurs conçus pour détecter la présence d'un applicateur connecté à chaque connecteur, et une unité de commande. Ce dernier est conçu pour permettre de délivrer de l'énergie à travers les applicateurs uniquement si au moins deux applicateurs respectifs sont reliés aux connecteurs.
PCT/EP2025/053209 2024-02-07 2025-02-07 Dispositif de thermoablation Pending WO2025168752A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT202400002527 2024-02-07
IT102024000002527 2024-02-07

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WO2025168752A1 true WO2025168752A1 (fr) 2025-08-14

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993442A (en) * 1997-03-25 1999-11-30 Termuno Kabushiki Kaisha Medical laser irradiation apparatus
US20100069899A1 (en) * 2006-12-05 2010-03-18 Francesco Lonero kit of optical fibers for percutaneous ablative treatment
WO2019053614A1 (fr) 2017-09-15 2019-03-21 Elesta S.R.L. Dispositif et procédé de guidage échographique d'aiguille dans des interventions mini-invasives
US20190175270A1 (en) 2017-12-11 2019-06-13 Covidien Lp Reusable transmission network for dividing energy and monitoring signals between surgical devices

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993442A (en) * 1997-03-25 1999-11-30 Termuno Kabushiki Kaisha Medical laser irradiation apparatus
US20100069899A1 (en) * 2006-12-05 2010-03-18 Francesco Lonero kit of optical fibers for percutaneous ablative treatment
WO2019053614A1 (fr) 2017-09-15 2019-03-21 Elesta S.R.L. Dispositif et procédé de guidage échographique d'aiguille dans des interventions mini-invasives
US20190175270A1 (en) 2017-12-11 2019-06-13 Covidien Lp Reusable transmission network for dividing energy and monitoring signals between surgical devices

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