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WO2025159117A1 - Film soluble dans l'eau pour emballage d'agent chimique et capsule d'emballage d'agent chimique - Google Patents

Film soluble dans l'eau pour emballage d'agent chimique et capsule d'emballage d'agent chimique

Info

Publication number
WO2025159117A1
WO2025159117A1 PCT/JP2025/001882 JP2025001882W WO2025159117A1 WO 2025159117 A1 WO2025159117 A1 WO 2025159117A1 JP 2025001882 W JP2025001882 W JP 2025001882W WO 2025159117 A1 WO2025159117 A1 WO 2025159117A1
Authority
WO
WIPO (PCT)
Prior art keywords
water
soluble film
polyvinyl alcohol
packaging
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2025/001882
Other languages
English (en)
Japanese (ja)
Inventor
将志 南部
忠正 下牧
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aicello Corp
Original Assignee
Aicello Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicello Corp filed Critical Aicello Corp
Publication of WO2025159117A1 publication Critical patent/WO2025159117A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/38—Packaging materials of special type or form
    • B65D65/46—Applications of disintegrable, dissolvable or edible materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F16/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F16/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F16/04—Acyclic compounds
    • C08F16/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Definitions

  • the present invention relates to a water-soluble film for packaging pharmaceuticals such as pesticides and detergents, and to a pharmaceutical packaging capsule.
  • Water-soluble films formed from water-soluble polyvinyl alcohol resins containing anionic group-modified polyvinyl alcohol resins are used as water-soluble films for packaging pesticides, detergents, and other chemicals, taking into consideration the solubility of the water-soluble film and its formability into packaging capsules.
  • a predetermined amount of chemical can be stored in the packaging capsules obtained by forming the water-soluble film, and by placing the packaging capsules containing the chemical in a predetermined amount of water, the water-soluble film dissolves, yielding an aqueous solution with the desired chemical concentration.
  • Such water-soluble films are obtained by forming a water-soluble polyvinyl alcohol-based resin containing an anionic group-modified polyvinyl alcohol-based resin, and the resin and/or the water-soluble film are heated during the film-forming process.
  • a water-soluble polyvinyl alcohol-based resin containing an antioxidant such as a triazole-based compound (Patent Document 1 below) or a sulfite (Patent Document 2 below) is used in the film formation process.
  • the water-soluble polyvinyl alcohol resin containing the antioxidant described above can prevent yellowing during film formation, thereby making it possible to obtain a transparent water-soluble film.
  • yellowing of the water-soluble film may occur.
  • the appearance of the packaging capsule is impaired and the drug stored therein appears to be deteriorated. Yellowing of packaging capsules containing detergents containing oxygen bleaching agents such as sodium percarbonate as a drug during storage was significant.
  • the present invention aims to provide a water-soluble film for packaging medicines and a medicine packaging capsule that can sufficiently reduce yellowing that occurs in the water-soluble film even when medicines are stored in packaging capsules made from the water-soluble film for long periods of time.
  • a water-soluble film for pharmaceutical packaging that can achieve the above-mentioned objective is characterized by containing a water-soluble polyvinyl alcohol resin including an anionic group-modified polyvinyl alcohol resin, a plasticizer, and an aldehyde scavenger.
  • the aldehyde scavenger is preferably a guanidine compound or urea derivative having an amino group.
  • the amount of the aldehyde scavenger is preferably 0.01 to 5 parts by mass, and more preferably 0.1 to 5 parts by mass, per 100 parts by mass of the water-soluble polyvinyl alcohol resin.
  • the anionic group-modified polyvinyl alcohol resin is a maleic acid-modified polyvinyl alcohol resin, and that the degree of modification is 0.5 to 4.0 mol%.
  • the plasticizer preferably includes one or more selected from glycerin, sorbitol, polyethylene glycol, and diglycerin.
  • the water-soluble film contains a sulfite as an antioxidant.
  • a drug packaging capsule that can achieve the objectives of the present invention is one in which a drug is contained in a packaging capsule formed from the above-mentioned water-soluble drug packaging film.
  • the water-soluble film for packaging medicines according to the present invention is able to sufficiently reduce yellowing of the packaging capsules when medicines are stored in packaging capsules formed from the water-soluble film, and the appearance of the packaging capsules is not impaired, and the medicines stored do not appear to have deteriorated.
  • 1 is a graph showing that the yellowing of the water-soluble film forming the drug packaging capsule according to the present invention can be reduced compared to conventional water-soluble films.
  • the water-soluble film for packaging medicines according to the present invention contains a water-soluble polyvinyl alcohol resin including an anionic group-modified polyvinyl alcohol resin.
  • the anionic group-modified polyvinyl alcohol resin contained in the water-soluble polyvinyl alcohol resin is not particularly limited, but examples thereof include maleic acid-modified polyvinyl alcohol resin, itaconic acid-modified polyvinyl alcohol resin, acrylic acid-modified polyvinyl alcohol resin, methacrylic acid-modified polyvinyl alcohol resin, and 2-acrylamido-2-methylpropanesulfonic acid-modified polyvinyl alcohol resin.
  • the ratio (modification degree) of the number of moles of monomers reacted for modification to the number of moles of all monomers constituting the anionic group-modified polyvinyl alcohol-based resin is preferably 0.5 to 4.0 mol%, more preferably 0.5 to 2.0 mol%. If the modification degree of the anionic group-modified polyvinyl alcohol-based resin is less than 0.5 mol%, the solubility in water tends to decrease, and if it exceeds 4.0 mol%, the productivity of the anionic group-modified polyvinyl alcohol-based resin tends to decrease.
  • an anionic group-modified polyvinyl alcohol resin is preferably one in which the modified species is maleic acid-modified and the degree of modification is 0.5 to 4.0 mol %, since this improves the solubility of the drug packaging capsule in water.
  • the anionic group-modified polyvinyl alcohol resin used in the present invention may contain repeating units composed of the following monomers, provided that the effects of the present invention are not impaired.
  • monomers include olefins such as ethylene, propylene, isobutylene, ⁇ -octene, ⁇ -dodecene, and ⁇ -octadecene; fully alkyl esters of unsaturated acids such as acrylic acid, methacrylic acid, crotonic acid, maleic acid, maleic anhydride, and itaconic acid; nitriles such as acrylonitrile and methacrylonitrile; amides such as acrylamide and methacrylamide; alkyl vinyl ethers; N-acrylamidomethyltrimethylammonium chloride, allyltrimethylammonium chloride, dimethyldiallylammonium chloride, dimethylallyl vinyl ketone, N-vinylpyrrolidone, vinyl chloride, vinylidene chloride,
  • allyl ether polyoxyalkylene (meth)acrylates such as polyoxyethylene (meth)acrylate and polyoxypropylene (meth)acrylate, polyoxyalkylene (meth)acrylamides such as polyoxyethylene (meth)acrylamide and polyoxypropylene (meth)acrylamide, polyoxyethylene (1-(meth)acrylamide-1,1-dimethylpropyl) ester, polyoxyethylene vinyl ether, polyoxypropylene vinyl ether, polyoxyethylene allylamine, polyoxypropylene allylamine, polyoxyethylene vinylamine, polyoxypropylene vinylamine, diacrylacetonamide, and the like.
  • polyoxyalkylene (meth)acrylates such as polyoxyethylene (meth)acrylate and polyoxypropylene (meth)acrylate
  • polyoxyalkylene (meth)acrylamides such as polyoxyethylene (meth)acrylamide and polyoxypropylene (meth)acrylamide
  • cationic group-containing monomers such as N-acrylamidomethyltrimethylammonium chloride, N-acrylamidoethyltrimethylammonium chloride, N-acrylamidopropyltrimethylammonium chloride, 2-acryloxyethyltrimethylammonium chloride, 2-methacryloxyethyltrimethylammonium chloride, 2-hydroxy-3-methacryloyloxypropyltrimethylammonium chloride, allyltrimethylammonium chloride, methallyltrimethylammonium chloride, 3-butenetrimethylammonium chloride, dimethyldiallylammonium chloride, and diethyldiallylammonium chloride.
  • cationic group-containing monomers such as N-acrylamidomethyltrimethylammonium chloride, N-acrylamidoethyltrimethylammonium chloride, N-acrylamidopropyltrimethylammonium chloride, 2-acryloxyethyltrimethylammonium chloride, 2-meth
  • Anionic group-modified polyvinyl alcohol resins can be obtained by polymerizing a polymer by a known method, such as solution polymerization, bulk polymerization, or suspension polymerization, and then saponifying the polymer. Saponification is carried out using an alkali or acid, with alkali being particularly preferred.
  • the degree of saponification is not particularly limited, but is preferably in the range of 86 to 100 mol% because this makes it easy to adjust the solubility in water, more preferably 87 to 99 mol%, and even more preferably 88 to 94 mol%. If the degree of saponification is less than 86 mol%, the water solubility of the anionic group-modified polyvinyl alcohol resin tends to decrease. The degree of saponification is measured in accordance with JIS K6726 (1994).
  • the degree of polymerization of the anionic group-modified polyvinyl alcohol resin is not particularly limited, but is preferably 700 or more, more preferably 900 or more, and even more preferably 1200 or more. If the degree of polymerization is less than 700, the mechanical properties of the water-soluble film and the pressure resistance of the final packaging capsule tend to decrease.
  • the upper limit of the degree of polymerization is preferably 2500, more preferably 2200 or less, and even more preferably 1700 or less. If the degree of polymerization exceeds 2500, the water solubility of the water-soluble film tends to decrease.
  • the viscosity of a 4% by weight aqueous solution of an anionic group-modified polyvinyl alcohol resin at 20°C is not particularly limited, but is preferably 7.0 to 55 mPa ⁇ s, more preferably 9.0 to 50 mPa ⁇ s, and even more preferably 12 to 35 mPa ⁇ s.
  • the viscosity of a 4% by weight aqueous solution is measured in accordance with JIS K6726 (1994).
  • the water-soluble polyvinyl alcohol resin forming the water-soluble film of the present invention may be made of multiple types of anionic group-modified polyvinyl alcohol resins.
  • anionic group-modified polyvinyl alcohol resins that differ in at least one of the following characteristics can be used: molecular weight, degree of polymerization, viscosity of a 4% by mass aqueous solution, degree of saponification, degree of modification, modified species, etc.
  • other modified polyvinyl alcohol resins and/or unmodified polyvinyl alcohol resins may be contained as necessary, provided that the object of the present invention is not impaired.
  • the water-soluble film of the present invention contains a plasticizer to ensure moldability and prevent embrittlement of the film.
  • the plasticizer preferably contains one or more selected from glycerin, sorbitol, polyethylene glycol, and diglycerin. Sorbitol is a sugar alcohol having a melting point of 80°C or higher.
  • the polyethylene glycol preferably has a weight-average molecular weight (hereinafter simply referred to as average molecular weight) of 106 or more, more preferably 150 to 400, and particularly preferably 200.
  • Polyethylene glycols with an average molecular weight of less than 106 tend to volatilize easily from the water-soluble film, while those with an average molecular weight of more than 400 tend to have reduced compatibility with water-soluble polyvinyl alcohol resins containing anionic group-modified polyvinyl alcohol resins.
  • the content of the plasticizer is preferably 5 to 50 parts by mass, more preferably 8 to 40 parts by mass, and even more preferably 10 to 35 parts by mass, relative to 100 parts by mass of the water-soluble polyvinyl alcohol resin.
  • the amount of plasticizer is less than 5 parts by mass, the flexibility of the water-soluble film will be insufficient and processability will be reduced, while if the amount of plasticizer exceeds 50 parts by mass, the plasticizer will bleed out, making the film more likely to become sticky.
  • the water-soluble film of the present invention may contain commonly used plasticizers, as long as they do not impair the objectives of the present invention, such as polyhydric alcohols such as diethylene glycol, trimethylolpropane, triethylene glycol, dipropylene glycol, propylene glycol, 2-methyl-1,3-propanediol, and polyglycerin, polyethers such as polypropylene glycol, phenol derivatives such as bisphenol A and bisphenol S, sugar alcohols such as mannitol, xylitol, and pentaerythritol, amide compounds such as N-methylpyrrolidone, and compounds obtained by adding ethylene oxide to polyhydric alcohols such as pentaerythritol and sorbitol. These may be used alone or in combination of two or more types.
  • plasticizers such as diethylene glycol, trimethylolpropane, triethylene glycol, dipropylene glycol, propylene glycol, 2-methyl-1,3-propan
  • the water-soluble polyvinyl alcohol resin forming the water-soluble film of the present invention preferably contains an antioxidant to prevent yellowing due to oxidation caused by heating during the film-forming process.
  • the antioxidant is preferably a sulfite, and specific examples include alkali metal salts of sulfite (e.g., sodium sulfite, potassium sulfite, etc.), with sodium sulfite being preferred.
  • the sulfite content is preferably 0.1 to 1.9 parts by mass, more preferably 0.3 to 1.5 parts by mass, and even more preferably 0.3 to 1.1 parts by mass, per 100 parts by mass of the water-soluble polyvinyl alcohol resin.
  • a sulfite content within this range can prevent yellowing due to heating during film formation or molding, and can also prevent sulfite precipitation during storage of the formed water-soluble film.
  • the water-soluble film according to the present invention contains an aldehyde scavenger that captures aldehyde components generated during the decomposition of a water-soluble polyvinyl alcohol-based resin.
  • Any aldehyde scavenger can be used as long as it has the ability to capture aldehyde components generated during the decomposition of a water-soluble polyvinyl alcohol-based resin and is compatible with the water-soluble polyvinyl alcohol-based resin.
  • aldehyde scavengers include compounds having an amino group that reacts with aldehyde components, specifically guanidine compounds or urea derivatives having an amino group.
  • aminoguanidine hydrochloride semicarbazide hydrochloride
  • Aircleans FC-HA010D trade name; an aqueous solution containing 16 ⁇ 1% by mass of a guanidine compound, an inorganic salt, and malic acid, ⁇ 0.3% by mass of a nonionic surfactant (penetrating agent), and a pH adjuster) manufactured by Union Chemical Co., Ltd.
  • Chemcatch H6000HS and Chemcatch P9600 both trade names; aldehyde catcher agents containing an amino group-containing compound as an active ingredient manufactured by Otsuka Chemical Co., Ltd.
  • the content of the aldehyde scavenger is preferably 0.01 to 5 parts by mass, more preferably 0.1 to 5 parts by mass, and even more preferably 0.1 to 3 parts by mass, per 100 parts by mass of the water-soluble polyvinyl alcohol-based resin. If the content of the aldehyde scavenger is less than 0.01 part by mass, the aldehyde component generated by decomposition of the water-soluble polyvinyl alcohol-based resin tends to be insufficiently captured. On the other hand, if the content of the aldehyde scavenger exceeds 5 parts by mass, the aldehyde scavenger tends to precipitate on the surface of the water-soluble film.
  • the packaging capsules formed from the water-soluble film formed to contain an aldehyde scavenger can sufficiently reduce yellowing of the water-soluble film and the packaging capsules even when storing a drug therein, compared to the packaging capsules formed from the water-soluble film formed to contain no aldehyde scavenger.
  • the reason for this is presumed to be as follows. Water-soluble polyvinyl alcohol resins deteriorate and yellow in a two-stage manner. In the first stage, hydroxyl groups are oxidized to carbonyl groups.
  • the carbonyl-initiated dehydration generates conjugated double bonds, resulting in the elongation of the conjugated system, and/or the carbonyl-initiated scission of the main chain generates lower aldehydes, which then undergo aldol condensation with each other, followed by dehydration and oxidation, resulting in the accumulation of unsaturated carboxylic acids such as crotonic acid, which are yellow substances.
  • the combination of the carbonyl-initiated dehydration generates conjugated double bonds, resulting in the elongation of the conjugated system, and the carbonyl-initiated scission of the main chain results in the yellowing of water-soluble films containing the water-soluble polyvinyl alcohol resin.
  • the first stage of oxidation can be prevented by antioxidants such as sulfites contained in the water-soluble polyvinyl alcohol resin, but the antioxidant exerts its antioxidant effect during heating during film formation and is significantly reduced, so it is presumed that the antioxidant does not exert a sufficient antioxidant effect during storage of the packaging capsules containing the drug.
  • the second stage of conjugated double bond formation and the accompanying elongation of the conjugated system are dehydration reactions, and the scission of the main chain starting from the carbonyl is a retro-aldol reaction, so it is presumed that antioxidants cannot suppress yellowing.
  • the second stage is likely to progress in packaging capsules containing detergents containing oxygen-based bleaching agents such as sodium percarbonate, and the water-soluble film forming the packaging capsules is likely to yellow.
  • the aldehyde or lower aldehyde produced in the second stage reacts with the amino group of the aldehyde scavenger to produce imine, which inhibits aldol condensation between aldehyde components and inhibits the production of unsaturated carboxylic acids, which are yellow substances, and prevents yellowing of the water-soluble film containing the water-soluble polyvinyl alcohol resin.
  • the water-soluble film of the present invention may contain other additives, such as surfactants, water-soluble polymers, and additives, within the range that does not impair the physical properties of the water-soluble film.
  • surfactants include nonionic surfactants, anionic surfactants, cationic surfactants, and zwitterionic surfactants.
  • preferred surfactants are polyoxyethylene lauryl ether acetate sodium salt, polyoxyethylene alkyl ether phosphate potassium salt, di-2-ethylhexyl sulfosuccinate sodium salt, and polyoxyethylene alkyl ether sulfate sodium salt. These may be used alone or in combination.
  • the content of the surfactant is preferably 0.03 to 1.00 parts by mass, more preferably 0.1 to 0.7 parts by mass, and even more preferably 0.2 to 0.4 parts by mass, per 100 parts by mass of the water-soluble polyvinyl alcohol-based resin.
  • the surfactant can impart releasability from the cast surface during production of the water-soluble film, or facilitate processing such as sealing (water-sealing, heat sealing) when producing pharmaceuticals, particularly liquid detergent packaging capsules, powder detergent packaging capsules, or packaging capsules containing powder detergent and liquid detergent.
  • water-soluble polymers include sodium polyacrylate, polyethylene oxide, polyvinylpyrrolidone, dextrin, chitosan, chitin, methylcellulose, and hydroxyethyl cellulose.
  • Additives include various fillers such as silica, aluminosilicate (zeolite), titanium oxide, talc, starch, and crosslinked acrylic microparticles, colorants, fragrances, bulking agents, antifoaming agents, release agents, ultraviolet absorbers, rust inhibitors, liquid paraffins, fluorescent brighteners, chelating agents, bittering agents such as denatonium benzoate, fatty acid substances, and inorganic powders.
  • the method for producing a water-soluble film for packaging pharmaceuticals of the present invention includes a step of preparing an aqueous solution and a film-forming step of producing a water-soluble film.
  • the method for preparing the aqueous solution in the step of preparing the aqueous solution is not particularly limited, and examples thereof include a method of dissolving a water-soluble polyvinyl alcohol-based resin and additives such as a plasticizer, a surfactant, and a filler in a dissolution tank or the like, and a method of kneading a water-containing water-soluble polyvinyl alcohol-based resin together with additives such as a plasticizer, a surfactant, and a filler using a twin-screw extruder.
  • the method for producing a water-soluble film containing a water-soluble polyvinyl alcohol resin is not particularly limited, but may be, for example, a method in which an aqueous solution or aqueous solvent solution of a water-soluble film composition containing a water-soluble polyvinyl alcohol resin is supplied to the surface of a rotating metal roll or the like (including the surface of a metal belt) serving as a support member using a known device, and then peeled off from the surface of the metal roll or the like (including the surface of a metal belt) and wound up while drying.
  • known means such as a solution casting method (casting method) or a roll coating method can be used as this supply method.
  • the water-soluble film may be embossed, for example, matte embossed, by heating and pressing it between two rollers having embossed irregularities on the surface to form an embossed pattern.
  • the moisture content of the water-soluble film of the present invention obtained by film formation is preferably 4.0 to 9.0% by mass, more preferably 4.5 to 8.0% by mass, and even more preferably 5.0 to 7.5% by mass, under conditions of room temperature, normal pressure, and normal humidity. If the moisture content is less than 4.0% by mass, the flexibility of the water-soluble film tends to decrease, and if the moisture content exceeds 9.0% by mass, the water-soluble film tends to adhere to itself.
  • the thickness of the water-soluble film for drug packaging of the present invention obtained by film formation is preferably 20 to 120 ⁇ m, more preferably 50 to 110 ⁇ m, and even more preferably 60 to 90 ⁇ m.
  • Water-soluble films with a thickness of less than 20 ⁇ m tend to lack tensile strength for use in drug packaging capsules, while water-soluble films with a thickness of more than 120 ⁇ m tend to have reduced formability when formed into drug packaging capsules.
  • the resulting water-soluble film for pharmaceutical packaging may consist of only one layer, or may be formed by laminating two or more layers of the same or different water-soluble films having the same water-soluble film composition.
  • a capsule packaged using such a water-soluble film is formed by bonding the edges of at least two sheets of water-soluble film together, and contains a pharmaceutical such as a detergent.
  • pharmaceutical packaging capsules are produced by filling and sealing the contents with heat sealing or water sealing.
  • Pharmaceutical packaging capsules are preferably formed by a thermoforming method or a vertical-form-fill-seal (VFFS) method, with those formed by a thermoforming method being more preferred.
  • VFFS vertical-form-fill-seal
  • the packaging capsule formed with the water-soluble film for packaging medicinal products of the present invention is suitable for storing powder detergent as the medicinal product. It may also store powder detergent and liquid detergent and/or gel detergent. It may also be a single-package, multi-chamber detergent packaging capsule that stores a single powder detergent or liquid detergent, or two or more separate powder detergents and liquid detergents. It may also be an agrochemical packaging capsule that stores agrochemical as the medicinal product.
  • the water-soluble film of the present invention is useful for packaging chemicals containing oxygen bleaching agents such as sodium percarbonate, preferably powder detergents containing oxygen bleaching agents such as sodium percarbonate.
  • the water-soluble film composition contains the following water-soluble polyvinyl alcohol (PVA) resins: A-1: Maleic acid-modified polyvinyl alcohol resin, polymerization degree: 1700, saponification degree: 88 mol%, modification degree: 1.9 mol%.
  • PVA polyvinyl alcohol
  • the water-soluble film composition shown in Table 1 was formed into a film.
  • the viscosity of this composition was approximately 3000 mPa ⁇ s when measured at 85°C using a Brookfield viscometer.
  • a metal roll was prepared as a casting surface, and its surface was cleaned by wiping with a cloth dampened with pure water.
  • the water-soluble film composition was cast onto the metal roll while heating the surface temperature of the metal roll to approximately 80 to 95°C.
  • the metal roll was dried for 8 minutes while rotating, producing a water-soluble film for packaging capsules with a thickness of 75 ⁇ m.
  • the moisture content of the resulting water-soluble film was measured in accordance with JIS K 6726 3.4, and the resulting volatile content value was measured as the moisture content.
  • the packaged capsule containing the powder detergent was then placed in a PET 15 ⁇ m/PE 50 ⁇ m laminated bag, sealed, and stored in an accelerated environment of 40°C and 20% RH for 14 days. After storage, the heat-sealed portion of the packaging capsule was cut off, the detergent was removed, and the detergent adhering to the film was wiped off.
  • the yellowness index (YI value) of the water-soluble film was then measured using a spectrophotometer (SD 7000, manufactured by Nippon Denshoku Industries Co., Ltd.) in accordance with JIS Z8722 (2009). The results are shown in Table 2 below. Table 2 also lists the moisture content (measured in accordance with JIS K 6726 3.4) and initial YI value of the water-soluble film obtained by film formation.
  • Examples 1 to 10 which contain an aldehyde scavenger, all have reduced YI values after 14 days of storage compared to Comparative Example 1, which does not contain an aldehyde scavenger.
  • Examples 1 to 6 and 10 which use a combination of an antioxidant and an aldehyde scavenger, have even lower YI values after 14 days of storage compared to Example 7, which contains only an aldehyde scavenger.
  • the water-soluble film forming the packaging capsules in Example 5 had a YI value of less than 1.0 after 14 days of storage, and the water-soluble film was not yellowish to the naked eye and was sufficiently colorless and transparent.
  • Examples 8 and 9 do not contain an antioxidant, but by using multiple types of plasticizers, the YI value after 14 days of storage is even lower than Examples 1 to 4, 6, and 10, which contain an antioxidant.
  • the water-soluble film for packaging pharmaceuticals according to the present invention can be used in packaging capsules for packaging and storing pharmaceuticals such as pesticides and detergents.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Wrappers (AREA)

Abstract

L'invention concerne un film soluble dans l'eau pour emballage d'agent chimique, qui, même lorsqu'un agent chimique est logé dans une capsule d'emballage formée du film soluble dans l'eau et est stocké pendant une longue période de temps, est capable de réduire suffisamment le jaunissement qui se produit dans le film soluble dans l'eau. Ce film soluble dans l'eau pour emballage d'agent chimique est caractérisé en ce qu'il comprend : une résine à base d'alcool polyvinylique soluble dans l'eau comprenant une résine à base d'alcool polyvinylique modifiée par un groupe anionique ; un plastifiant ; et un piégeur d'aldéhyde. Le piégeur d'aldéhyde est de préférence un dérivé d'urée ou un composé à base de guanidine ayant un groupe amino.
PCT/JP2025/001882 2024-01-26 2025-01-22 Film soluble dans l'eau pour emballage d'agent chimique et capsule d'emballage d'agent chimique Pending WO2025159117A1 (fr)

Applications Claiming Priority (2)

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JP2024010262 2024-01-26

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