[go: up one dir, main page]

WO2025153557A1 - Module de laboratoire comprenant un dispositif de transport de distribution avec deux dispositifs de réception de distribution, chacun étant conçu pour recevoir au moins un objet de laboratoire respectif - Google Patents

Module de laboratoire comprenant un dispositif de transport de distribution avec deux dispositifs de réception de distribution, chacun étant conçu pour recevoir au moins un objet de laboratoire respectif

Info

Publication number
WO2025153557A1
WO2025153557A1 PCT/EP2025/050931 EP2025050931W WO2025153557A1 WO 2025153557 A1 WO2025153557 A1 WO 2025153557A1 EP 2025050931 W EP2025050931 W EP 2025050931W WO 2025153557 A1 WO2025153557 A1 WO 2025153557A1
Authority
WO
WIPO (PCT)
Prior art keywords
laboratory
delivery
module
transport
receiving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2025/050931
Other languages
German (de)
English (en)
Inventor
Martin Schumacher
Ramon Federspiel
Andrea Hermsmeyer
Sabina Breitenmoser
Reto MENZI
Marcel Albertin
Raphael Weichselbraun
Christoph Gringer
Pierino Rizzi
Vinicius Barros
Fabian Dürig
Ivica Arambasic
Reto Kurz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamilton Bonaduz AG
Original Assignee
Hamilton Bonaduz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamilton Bonaduz AG filed Critical Hamilton Bonaduz AG
Publication of WO2025153557A1 publication Critical patent/WO2025153557A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples
    • G01N2035/0422—Plate elements with several rows of samples carried on a linear conveyor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples
    • G01N2035/0422—Plate elements with several rows of samples carried on a linear conveyor
    • G01N2035/0424—Two or more linear conveyors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Definitions

  • the present invention relates to a laboratory module with a delivery transport device that is movable along a delivery transport path in order to transport at least one laboratory object within the laboratory module along the delivery transport path.
  • the delivery transport device has a delivery receiving arrangement designed to receive at least one laboratory object.
  • Such a laboratory module preferably serves as a building block for forming a laboratory arrangement, which can be easily and quickly assembled from a plurality of laboratory modules according to the desired or required functions.
  • US 6739448 B1 discloses a transport device for transporting sample carriers between different processing stations in an at least partially automated laboratory system.
  • sample carriers mentioned in US 6739448 B1 include microtiter plates and boxes with pipette tips.
  • the laboratory system has several processing stations arranged at different positions, each with a station support surface to which the known transport device can deliver a transported sample carrier for processing by the processing station.
  • the known transport device can be moved along a transport path between the processing stations.
  • US 6739448 B1 highlights a special feature of the transport device described therein: it always engages a sample carrier only from the base.
  • the sample carrier rests on a transport surface of the known transport device for transport along the transport path and, after reaching a target processing station, is transferred to the station support surface of this target processing station.
  • the transport surface has a C-shaped surface with a free or recessed inner area surrounded by the C-shaped transport surface.
  • the surface of the station support surface is essentially complementary to the transport surface and is limited to the free inner area of the complementary C-shaped transport surface.
  • the station support surface can only be raised and lowered along a path orthogonal to the parallel planes of extension of the transport surface and station support surface.
  • the station support surface has no other degree of freedom of movement.
  • the sample carrier initially resting on the transport surface can be lifted off the transport surface by means of the station support surface and thus picked up.
  • the sample carrier initially resting on the station support surface can be placed on the transport surface and thus transferred to it. If one considers the described transfer processes between the transport surface and the station support surface in a respective coordinate system that moves with the initially unloaded surface from the transport surface and the station support surface that receives the sample carrier, the sample carrier is stripped off the originally supporting surface at the receiving surface during each transfer.
  • the C-shaped transport surface can be arranged on a frame of the transport device so as to be rotatable about an axis of rotation orthogonal to its transport surface plane.
  • EP 0 990 906 A1 discloses an automatic laboratory analysis system with a transport device operating therein.
  • the system known from EP 0 990 906 A1 The transport device is housed in a dedicated device housing and is used to transport components from one device of the laboratory analysis system to another device of the laboratory analysis system, with each of the devices being housed in its own device housing.
  • the device housing is connected to one of the device housings and is aligned relative to the other device housing.
  • EP 0 990 906 A1 lists sample tubes, liquid containers and disposable pipetting tips as possible transported components.
  • the component carriers are designed with a protruding shoulder at their upper end, which is used as intended, so that a component carrier threaded into the mouth opening can be held by the frame with its protruding shoulder in a form-fitting manner by gravity, resting on the frame of the loading mouth.
  • EP 3 450 985 A1 discloses a device for processing microtiter plates.
  • the device draws microtiter plates horizontally into its body through a drawer.
  • the drawer can be extended and retracted horizontally through a slot in the front of the device, orthogonal to the front of the device.
  • the known device can be used, for example, as a patch clamp system for electrophysiology, as an absorption microplate reader, as a fluorescence microplate reader, as a luminescence microplate reader, as a cell imaging system, as a device for performing electroporation for transfection, as a device for level measurement in microtiter plates, and as a detection device ("reader") for microarrays in microtiter plates.
  • the lift In front of the drawer is a lift, which can only be moved vertically parallel to the front of the device.
  • the lift is a microtiter plate storage unit in which the microtiter plates to be processed by the device are stored vertically one above the other.
  • the drawer has a C-shaped frame, the free interior of which allows for The lift's carrier plate can be moved vertically through the tray.
  • the C-shaped frame is dimensioned such that a microtiter plate can be placed on it.
  • the lift's carrier plate is smaller than the base area of a microtiter plate, so that a carrier plate loaded with a microtiter plate can move vertically downward through the free interior of the tray's C-shaped frame, thereby stripping the microtiter plate it carries against the tray.
  • the carrier plate can lift a microtiter plate that is ready for transfer from the extended tray by moving vertically through the free interior space of the tray's C-shaped frame.
  • the then empty tray can be retracted back into the device body, whereupon the lift can move the received microtiter plate vertically to a desired location.
  • sample carriers While sample carriers are moved horizontally along the conveyor belt, the sample carriers in the sample carrier storage are moved vertically to transfer a desired stored sample carrier from the sample carrier storage to the conveyor belt.
  • the sample carriers are identified by barcode.
  • At least one station of the analysis device is a barcode reader.
  • the system comprises grid-like storage stations, each of which can accommodate a microtiter plate.
  • Above the storage stations is an opening device that can be moved in three pairs of orthogonal spatial directions to approach a storage station, grasp a cover of a microtiter plate arranged thereon, and lift it off the microtiter plate.
  • the present invention achieves this object by means of a laboratory module having all the features of granted claim 1.
  • the delivery-receiving arrangement comprises two delivery-receiving devices, each designed to receive a laboratory object for transport by the delivery-transport device.
  • the two delivery-receiving devices are movable together along the delivery-transport path.
  • the laboratory module preferably comprises a processing device, different from a transport device, such as the delivery transport device, for carrying out the laboratory processing process.
  • the processing object can be a solid or a liquid.
  • a processing device in a laboratory module requires not only one laboratory item on which the processing device performs a laboratory task, but several laboratory items that must be used together to perform a laboratory or processing task.
  • An illustrative, but not limiting, example is a pipetting device.
  • a device is mentioned as a preferred processing device of the present invention, which is supplied with laboratory items from the delivery/transport device. If the pipetting device is to be used with the broadest possible range of functions, the pipetting device requires a source container from which it can aspirate a dosing liquid as the object to be processed to perform a pipetting task.
  • An advantageously rigid and at the same time lightweight delivery receiving arrangement and thus a delivery transport device with advantageously low moving mass can be achieved.
  • This can be achieved by arranging the two delivery and receiving devices so that they are immobile relative to one another. Then, the two delivery and receiving devices can only be moved together, whether along the delivery transport route or along the transfer track.
  • the support engagement can preferably be established by placing or setting down the laboratory object on one of the delivery receiving devices, preferably on each of the two delivery receiving devices, of the delivery transport device.
  • the support engagement can preferably be removed by lifting the laboratory object from one of the delivery receiving devices, preferably from each of the two delivery receiving devices, of the delivery transport device.
  • a delivery/transport device with higher dynamics can be achieved if at least one delivery/receiving device, preferably both delivery/receiving devices, has or have at least one form-locking element, preferably several form-locking elements, such as projections and/or recesses, which limit the movement of a laboratory object, which is held on the appropriately equipped delivery/receiving device as intended for transport, parallel to a contact surface of its support engagement in at least one direction, preferably in opposite directions, particularly preferably in each direction along two displacement axes that are orthogonal to one another and parallel to the contact surface.
  • form-locking element preferably several form-locking elements, such as projections and/or recesses
  • the laboratory object can then be accelerated from a standstill with high acceleration and decelerated from a moving position with equally high deceleration, without fear of displacement of the laboratory object relative to the delivery/receiving device supporting it.
  • the contact surface of the support engagement is the area where the laboratory object, when in support engagement with a delivery/receiving device, touches the delivery/receiving device.
  • the first or second delivery support surface arrangement can be delimited by the above-mentioned at least one form-fitting element, such as one or more projections, which protrudes in a direction away from the respective delivery support surface arrangement. This preferably applies to both the first and the second delivery support surface arrangement.
  • each of the two delivery receiving devices preferably interacts with another device for receiving and preferably also for transferring a laboratory item to be transported or a transported item during operation of the laboratory module
  • the two delivery receiving devices can differ in terms of shape and/or size, so that each of the two delivery receiving devices can only cooperate with a specific other device, while the other of the two delivery receiving devices cannot. This can prevent incorrect loading of the individual delivery receiving devices.
  • the advantage of this preferred embodiment is that the above-mentioned additional devices that cooperate with the delivery receiving devices for transferring a laboratory object to be transported or being transported can also be designed as an inner or outer receiving device, such as the inner or outer delivery receiving device. Then, the inner delivery receiving device preferably cooperates with an outer receiving device, and the outer delivery receiving device cooperates with an inner receiving device. In this way, the delivery receiving devices can cooperate with the delivery receiving devices for transferring a laboratory object. acting further receiving devices may be formed from essentially two types of identical parts or comprise two types of identical parts, namely an outer receiving device or a receiving frame and an inner receiving device or a receiving carrier.
  • a laboratory object can be transferred between a delivery-receiving device and a further receiving device in an advantageous manner without the involvement of a further transfer device, such as a gripper or pusher, if the delivery-receiving device of the delivery-receiving arrangement comprises or is a receiving frame or a receiving carrier and if the further receiving device cooperating with the delivery-receiving device is the other structure comprising the receiving frame and the receiving carrier.
  • a further transfer device such as a gripper or pusher
  • the first and/or second delivery/receiving device can have a solid plate forming the support surface arrangement of the delivery/receiving device or contributing to its formation, in particular to support the functional device.
  • the solid plate can have at least one heating element by means of which a laboratory object in contact with the receiving device can be heated or warmed.
  • the solid plate can carry and in particular surround the at least one heating element as a heat-conducting plate and ensure the most even distribution possible of the heat emitted by the heating element in the solid plate.
  • the solid plate can be made of metal or of a material that has a thermal conductivity comparable to that of metal, in particular aluminum or copper.
  • the laboratory module can comprise a feed transport device, wherein the feed transport device is designed to transport a laboratory object into a transfer area in which the feed transport device and the delivery transport device are designed to transfer the laboratory object at least from the feed transport device to the delivery transport device.
  • the feed transport device and the delivery transport device are designed in the transfer area for the bidirectional transfer of a laboratory object between the two transport devices.
  • the feed transport device is preferably movable along a feed transport path.
  • the feed transport device preferably has a feed receiving device designed to receive the laboratory object for transporting it along the feed transport path.
  • the feed receiving device is preferably one of the above-mentioned further devices or receiving devices which cooperate with one of the delivery receiving devices for transferring the laboratory object to be transported or being transported.
  • both the feed receiving device and the provision receiving device each preferably comprise an outer receiving device or a receiving frame or an inner receiving device or a receiving carrier. Particularly preferred are an outer receiving device or a receiving frame or an inner receiving device or a receiving carrier.
  • the laboratory module preferably has a module frame which surrounds and/or accommodates the laboratory module.
  • the module frame is preferably designed as a framework, for example as a cuboid frame with particularly good connection capabilities on all sides, in order to be able to arrange several laboratory modules in a row next to and/or behind and/or above one another and to connect them to one another.
  • the delivery transport device is preferably located entirely within the installation space of the laboratory module. If the module frame accommodates more than one laboratory module, which is preferred, the feed transport device is preferably only partially located within the installation space of the laboratory module, with the feed transport path then preferably extending past the laboratory modules accommodated in the module frame.
  • the laboratory module described above is characterized by extremely high positioning accuracy of transported laboratory objects while requiring minimal equipment.
  • One advantage of the laboratory module is that several laboratory modules, usually with different task or functional orientations, can be modularly configured to form a larger unit.
  • the present invention therefore also relates to a laboratory arrangement which, as laboratory work modules, comprises at least two laboratory modules as described and further developed above.
  • a laboratory object delivered to the laboratory work modules by the delivery and transport device can be a microtiter plate, a pipette tip arrangement with at least one pipette tip, a sample container, a sensor, a test specimen, and the like, or a subselection thereof.
  • the at least two laboratory work modules preferably follow one another in the laboratory arrangement along the direction of the feed and transport path.
  • a particular increase in efficiency can be achieved with this laboratory arrangement in that the at least two laboratory modules have a common feed transport device and each have at least one, preferably exactly one, delivery transport device and each have a transfer area.
  • the feed transport device thus reaches the at least two laboratory work modules of the laboratory arrangement and can thus transport a laboratory object from one laboratory work module of the laboratory arrangement to another laboratory work module of the same laboratory arrangement.
  • Each laboratory work module has Preferably, the device has its own delivery/transport device, which moves the laboratory object supplied by the feed/transport device into the respective laboratory work module and back again.
  • each laboratory work module has a processing device, which is supplied by the delivery/transport device, while the feed/transport device supplies laboratory objects to and removes them from the individual laboratory work modules of the laboratory arrangement.
  • the processing device is supplied with laboratory objects only by the delivery/transport device, while no processing device is located as a transport destination along the feed/transport path.
  • the laboratory work modules in particular the base plates supporting their components, preferably have uniform base dimensions in each of two mutually orthogonal base spatial directions. Uniform dimensions are dimensions that differ by no more than 7.5%, preferably no more than 5%, relative to the larger dimension along one and the same spatial direction.
  • the laboratory work modules, in particular the base plates supporting their components preferably have the same dimensions in each individual base spatial direction.
  • the laboratory arrangement does not have to be limited to one arrangement level of modules.
  • the laboratory arrangement can additionally comprise at least one laboratory base module, wherein a laboratory work module is arranged above a laboratory base module of the at least one laboratory base module, forming a module tier.
  • a laboratory base module is arranged above a laboratory base module of the at least one laboratory base module, forming a module tier.
  • the arrangement level of the laboratory base modules is preferably located below the arrangement level of the laboratory work modules.
  • the laboratory base modules can have a base module frame.
  • the base module frame is preferably designed as a framework, for example, as a cuboid frame with particularly good connection capabilities on all sides. Passages can then exist between adjacent laboratory base modules and to laboratory work modules arranged above them.
  • a laboratory base module and a laboratory work module arranged above it, in particular a laboratory work module supported by the laboratory base module, can use at least one common frame component, which is part of both the work module frame and the base module frame.
  • the laboratory object lift also conveys the laboratory objects received therein, the laboratory object lift is also a conveying device.
  • the laboratory object lift as a conveying device can be part of the laboratory work module or part of the laboratory base module or both part of the laboratory work module and part of the laboratory base module, between which it conveys a laboratory object.
  • Fig. 4 is a schematic perspective view of a first transport device of the laboratory arrangement of Fig. 1,
  • Fig. 9 is a schematic perspective view of an empty stack memory of the laboratory base module of Fig. 8,
  • Fig. 10 is a schematic perspective view of a loaded stack memory of the laboratory base module of Fig. 8,
  • Fig. 11 is a schematic perspective view of a base module level of a laboratory arrangement according to the invention with base modules pulled out of the base and work module frame,
  • Fig. 12 is a schematic perspective view of a transfer area of the laboratory arrangement of Fig. 1 before a transfer of a laboratory object from the first to the second transport device,
  • Fig. 13 is a schematic perspective view of the transfer area of the laboratory arrangement of Fig. 1 after a transfer of a laboratory object from the first to the second transport device,
  • Fig. 14 is a schematic perspective view of a laboratory work module with pipetting device of the laboratory arrangement of Fig. 1
  • Fig. 15 is a schematic perspective view of a working area of the pipetting device of a laboratory work module of the laboratory arrangement of Fig. 1.
  • a laboratory arrangement is generally designated by 10.
  • the laboratory arrangement 10 has an outer skin 12, which surrounds the devices and components arranged in the interior 14 of the laboratory arrangement 10 and shields them from the external environment U. Processes in the interior 14 of the laboratory arrangement 10 can be observed through a front window 16 and a side window 18.
  • a status light 22 on the top side of the outer skin 12 indicates one or more operating states of the laboratory arrangement 10 by means of light signals.
  • slide-in fronts 26, 28, and 30 are on the front side 12a of the outer skin 12, which can be unlocked by switches 24.
  • the slide-in fronts 26, 28, and 30, which are locked during operation, can be individually unlocked by actuating the switches 24.
  • Base modules connected to the slide-in fronts 26, 28, and 30, which are explained further below, can then be pulled out of the body 32 of the laboratory arrangement 10 defined by the outer skin 12 in the opposite direction to the y-direction and pushed back into the body 32 in the y-direction.
  • Manual inlets 34 facilitate the extraction of the base modules from the body 32.
  • the laboratory base modules 42a, 42b, and 42c are mounted side by side along the x-direction in a base and work module frame 46, which is constructed in a truss-like manner from vertical struts 48, horizontal cross struts 50 connecting the vertical struts 48, and horizontal longitudinal struts 52 connecting the cross struts 50.
  • Parallel plates 54 are arranged laterally on the outermost compartments in the x-direction.
  • the base module frame 46 is shown in isolation in Figure 3.
  • the base and work module frame 46 carries not only the three laboratory base modules 42a, 42b and 42c shown as examples, but also laboratory work modules 56a, 56b and 56c arranged in the work module level 40, which, like the laboratory Base modules 42a, 42b and 42c below, along the x-direction next to each other on the base and working module frame 46.
  • the first transport device 68 is a feed transport device 68, whose first transport path 70, which runs parallel to the x-direction and is also a feed transport path 70, leads past all three laboratory work modules 56a, 56b, and 56c, so that the first transport device 68 can transport a laboratory object to each individual laboratory work module 56a, 56b, and 56c of the work module level 40.
  • the transport base 82 is guided on the guide rail 80 by means of rolling element bearings.
  • the first receiving device 72 comprises, as an outer receiving device, a receiving frame with a base 72a, with legs 72b projecting therefrom at each longitudinal end of the base 72a, and with leg ends 72c angled toward one another at each longitudinal end of a leg 72b remote from the base 72a.
  • An inner region 73 of the outer first receiving device 72, configured as a receiving frame, is free of material of the first receiving device 72.
  • a support surface 75a, 75b, and 75c is formed (the support surfaces 75b and 75c are present twice, but can only be seen once in Figure 4 due to the chosen perspective).
  • the individual support surfaces 75a, 75b, and 75c form a first support surface arrangement 77 lying in a common plane, on which a storage surface of a laboratory object can rest in contact.
  • Figure 5 shows a perspective view of the laboratory work module 56b with the pipetting device 64 as the processing device 60 in isolation.
  • This simple kinematics of the pipetting device 64 enables a very simple design of the pipetting device 64 with only one motion guide for all pipetting channels 92, which can be implemented very precisely with little effort due to the single degree of freedom of movement along the channel axis K.
  • a second transport device 96 is attached on the longitudinal side of the base plate 90 facing away from the viewer in Figure 5.
  • This second transport device is a delivery transport device 96 that delivers laboratory items to the pipetting device 64 for carrying out pipetting operations.
  • the second transport device 96 is movable along a second transport path 98 or delivery transport path 98.
  • the second or delivery transport path 98 is defined by the path of a guide rail 100 of the second transport device 96.
  • the first and second transport devices 68 and 96 together form a transport arrangement 99 (see Figures 12 and 13).
  • the second receiving device 102 can be raised and lowered in the z-direction from the position shown in Figure 5 to carry out a transfer movement, which will be explained in more detail below.
  • the second transport base 106 has a transfer drive 116 comprising an electric motor drive 118, a vertically extending guide rail 120 that can be displaced together with the second transport base 106 along the second transport path 98, and a belt 122 of a transfer belt drive 124 that can be driven in opposite directions of rotation by the electric motor drive 118.
  • a transfer base 123 (see Figures 6, 7, 12, and 13) is guided on the guide rail 120, preferably with rolling element bearings, and is coupled to the belt 122 for joint movement.
  • the second receiving device 102 is directly coupled to the transfer base 123 for joint movement.
  • two essentially identical vertical guides 126 of a respective vertical laboratory object lift 128 are fixed to the base plate 90.
  • the vertical guides 126 pass through an opening 130 through which the respective laboratory object lift 128 can vertically convey laboratory objects as a conveying device from the base module level 38 to the work module level 40.
  • the first delivery receiving device 104a has a support surface arrangement 132, which in the illustrated embodiment is formed by four separate support surfaces 134a, 134b, 134c, and 134d.
  • the four support surfaces 134a, 134b, 134c, and 134d are located in the corner regions of the overall surface of the first delivery receiving device 104a.
  • the support surface arrangement 132 of the first delivery-receiving device 104a is dimensioned such that it can be moved through the interior region 73 of the first receiving device 72 in a direction of movement orthogonal to both the support surface arrangement 77 and the support surface arrangement 132 in opposite directions.
  • Such an orthogonal movement path corresponds to the transfer path or transfer relative movement path TRB running along the z-axis.
  • the first delivery receiving device 104a also has a solid plate 135 located radially inward of the four separate support surfaces 134a, 134b, 134c, and 134d.
  • This plate may be rectangular and, as shown in the preferred embodiment, may have rounded corners.
  • projections 136 are arranged orthogonally to the support surface arrangement 132, which secure a laboratory object resting on the support surface arrangement 132 against displacement orthogonal to the transfer relative movement path TRW or parallel to the support surface arrangement 132.
  • two projections 136 are arranged in each corner region so that the two projections 136 can rest against a common component edge of a laboratory object with, in this case, a rectangular base area, such as a microtiter plate.
  • the solid receiving plate 135 of the first delivery receiving device 104a can have a functional device 138, such as a heating device, a device for generating a magnetic field, or the receiving plate can be configured as an electrode for generating an electric field.
  • the first delivery receiving device 104a can also have a C-shaped receiving frame under the solid receiving plate 135 with a similar or identical base area to that of the C-shaped receiving frame of the second delivery receiving device 104b.
  • the receiving frame of the second delivery receiving device 104b also has a base 144a, at whose longitudinal end regions parallel legs 144b protrude in the same direction. In contrast to the receiving frame of the first delivery receiving device 72, the longitudinal end regions of the legs 144b are not angled towards one another.
  • the second delivery receiving device 104b like the first delivery receiving device 104a, is an inner receiving device. Due to its external dimensions, the second delivery receiving device 104b is also generally movable through the inner region 73 of the receiving device 72, assuming that the receiving device 72 is accessible by the second delivery receiving device 104b. In fact, the second delivery receiving device 104b is movable through the inner region 173 of the provision receiving device 172 (see Fig. 9), explained further below.
  • each corner area of the support surface arrangement 140 of the second delivery receiving device 104b in the same way as on the first delivery receiving device 104a, two orthogonal to the support surface arrangement 140 projecting Projections 136 are provided to secure a laboratory object resting on the support surface arrangement 140 against displacement parallel to the support surface arrangement 140.
  • the first delivery/receiving device 104a is connected via an extension arm 146 to the transfer base 123, which is guided along the guide rail 120 and driven by the belt 122, and is thus offset in the depth direction along the y-axis with respect to the guide rail 120.
  • the second delivery/receiving device 104b is located directly at the depth coordinate (y-coordinate) of the guide rail 120.
  • the movement guidance of the second transport base 106 may differ slightly in Figures 5 and 7 in details that are not important here.
  • Figure 8 shows a perspective view of the middle laboratory base module 42b, which in Figure 2 is inserted in the base and work module frame 46 below the laboratory work module 56b with the pipetting device 64.
  • the laboratory base module 42b has its own module frame 150, which is installed and secured in the base and work module frame 46.
  • the module frame 150 as the base module frame 150 in the narrower sense for a single laboratory base module 42b or 42c, is also constructed in a truss-like manner using struts.
  • the insert front 28 is the front of a insert 152, which can be pulled out of the module frame 150 along the y-axis. Also installed in the module frame 150 are two laboratory object lifts 128, whose push plates 154 can be seen on the top of the laboratory base module 42b. The push plates 154 are movable parallel to the z-direction by a corresponding conveyor drive and can move stack storage devices arranged in the drawer 152, along with their contents, in and against the z-direction.
  • a stack storage 156 is shown in perspective, wherein the stack storage in Figure 9 is empty and wherein the stack storage 156 in Figure 10 is populated with a subselection 158 of laboratory items.
  • the subselection 158 is a second subselection 158 comprising a source container 158a and a pipette tip assembly 158b as laboratory items.
  • Figure 11 shows how the stack storage units 156 of Figures 9 and 10 can be suspended in side walls 153 of the drawers 152 so that they can then be moved by a laboratory item lift 128 through the opening 130 in the base plate 90 into the workspace of an overlying laboratory work module 56b or another laboratory work module 56. If the specific design of a laboratory work module as a laboratory work module 56a, 56b, or 56c is not important below, the laboratory work module is designated "56" without lowercase letters.
  • the stack storage 156 extends predominantly in the z-direction, parallel to which it is displaced along a displacement path V by the laboratory object lift 128 during operation of the laboratory arrangement 10.
  • the stacking storage unit 156 has a base 159, which is provided with a central opening to save weight. At the opposite upper longitudinal end, the stacking storage unit 156 has a closed, circumferential stabilizing structure 160 with a carrying handle 162 extending through the stabilizing structure 160. An operator can grasp the carrying handle 162 to carry, manipulate, and set down the stacking storage unit 156.
  • a stack storage enclosure 164 incompletely encloses the stack storage 156 in the circumferential direction around the displacement path V. This enables the second delivery receiving device to engage the stack storage 156.
  • a vertical guide rail 166 is arranged, which extends over at least 70% of the height dimension of the stack storage 156.
  • the vertical guide rail 166 cooperates with the vertical guides 126 on the laboratory work module 56b to guide the vertical lifting and lowering movement by the laboratory object lift 128.
  • the stack storage 156 can be suspended in a vertical groove 168 of a suspension device 170 arranged on the inside of the side wall 153 of the insert 152 (see Figure 11).
  • the stack storage 156 can be provided in a laboratory base module 42b or 42c or in any other laboratory base module 42 until it is finally used by a laboratory work module 56 arranged above it, such as the laboratory work module 56b. If the specific design of a basic laboratory module as basic laboratory module 56a, 56b or 56c is not relevant below, the basic laboratory module is designated with "42" without lowercase letters.
  • each receiving structure 171 is arranged consecutively along a stacking axis S, which corresponds to the displacement path V.
  • the receiving structures 171 serve to receive the second sub-selection 158 for reception by the second delivery receiving device 104b of the second transport device 96 in the laboratory work module 56b.
  • the identically designed receiving structures 171 have a receiving frame, which corresponds in shape to the first receiving device 72.
  • This receiving frame is a provision receiving device 172 designed as a receiving frame.
  • the provision receiving device 172 like the first receiving device 72, is an external receiving device. It can also be connected to the delivery receiving devices 104a and 104b, preferably to the second Delivery receiver 104b, for a transfer of the provided subselection 158 between the stack 156 and the delivery receiver cooperate like the first receiver 72.
  • What is said in the present description regarding the interaction between one of the first delivery receivers 104a and the first receiver 72 also applies, mutatis mutandis, to a description of the interaction between the second delivery receiver 104b and a provision receiver 172.
  • the description of the first receiver 72 also applies to the description of the provision receiver 172.
  • the provision receiving device 172 has, in its interior region 173, a solid plate 174 projecting from the base 172a of the receiving frame of the provision receiving device 172.
  • Legs corresponding to the legs 72b of the first receiving device 72 are designated 172b on the provision receiving device 172. The same applies to the leg ends 172c angled toward one another in relation to the previously explained leg ends 72c.
  • Figure 11 shows inserts 152 pulled out of a base and work module frame 46 in the opposite direction to the y-direction.
  • the base and work module frame 46 of Figure 11 comprises, for example, more than three laboratory base modules 42, which is readily possible within the scope of the present invention.
  • the laboratory base modules shown in Figure 11 correspond in design to the laboratory base module 42b.
  • the frontmost outermost stack storage 156 shows how it can be moved along the z-direction, ie along a displacement path V not shown in Figure 11, via the push plates 154 (see Fig. 8) which can be displaced in the height direction, ie in the z-direction, starting from its hanging position into the laboratory work module 56 located above.
  • FIG. 12 and 13 the transfer of a microtiter plate 158c as a laboratory item is shown to be a first sub-selection 157 of a set of laboratory items comprising the microtiter plate 158c as a target vessel, the source vessel 158a, and the pipetting tip assembly 158b, which is required for performing a pipetting task by the pipetting device 64.
  • the microtiter plate 158c is in contact with the first receiving device 72, which has moved the microtiter plate 158c into a transfer area 176 along the first transport path 70. In the transfer area 176, a transfer of the microtiter plate 158c from the first receiving device 72 to the first delivery receiving device 104a or vice versa is possible.
  • the first receiving device 72 When the first receiving device 72 is in the position associated with the transfer area 176 along the first transport path 70, the first receiving device 72 forms a transfer station 178 for a transfer of the microtiter plate 158c from the first receiving device 72 to the first delivery receiving device 104a.
  • Figure 12 shows a situation before a transfer of the microtiter plate 158c from the first receiving device 72 to the first delivery receiving device 104a, in which the second receiving device 102 with the receiving arrangement 104 comprising the first and second delivery receiving devices 104a and 104b is in the fully lowered position along the transfer relative movement path TRB.
  • Figure 13 shows the transfer area 176 with a receiving arrangement 104 completely raised along the transfer relative movement path TRB, wherein the first delivery receiving device 104a completely traverses the inner area 73 of the first receiving device 72 in the vertical direction along the transfer relative movement path TRB and in the process has lifted the microtiter plate 158c from the first receiving device 72 by establishing a support engagement with the first delivery receiving device 104a as described above.
  • This type of transfer of a microtiter plate 158c between the first delivery receiving device 104a and the first receiving device 72 is referred to in the present application as a stripping transfer, regardless of the transfer direction.
  • the receiving arrangement 104 After the receiving arrangement 104 has been moved out of the extension area of the first receiving device 72 along the second transport path 98, it is lowered along the transfer relative movement path TRB.
  • a transfer of the second sub-selection 158 with the source container 158a and the pipette tip assembly 158b as the laboratory items of the second sub-selection 158 mutatis mutandis between the second delivery receiving device 104b and the provision receiving device 172 proceeds in the same way as the transfer of the first sub-selection 157 or the microtiter plate 158c between the first delivery receiving device 104a and the first receiving device 72.
  • the receiving arrangement 104 or the first delivery receiving device 104a can be lowered along the transfer relative movement path TRB relative to the first receiving device 72 to such an extent that the first delivery receiving device 104a, with the microtiter plate 158c resting thereon, can be moved along the second transport path 98 below the first receiving device 72 provided in the transfer area 176. This ensures that the first receiving device 72 can be moved along the first transport path 70 regardless of whether the first delivery receiving device 104a is loaded and regardless of its position along its second transport path 98. Furthermore, a microtiter plate 158c in contact with the first delivery receiving device 104a can be moved as desired along the second transport path 98.
  • the pipetting device 64 pipettes from its pipetting channels 92 into the microtiter plate 158c as the source container, while This rests on the first delivery receiving device 104a.
  • mobility of the pipetting channels 92 only along their pipetting channels K, which in the illustrated embodiment run parallel to the z-direction, is sufficient as the only degree of freedom of movement of the pipetting channels 92.
  • the pipetting device 64 can be constructed much more simply and cost-effectively while maintaining the same positioning accuracy of its pipetting channels 92.
  • a second sub-selection 158 with a plurality of source containers 158a and a plurality of pipette tip assemblies 158b is received on the second delivery receiving device 104b and is in supporting engagement therewith.
  • the second sub-selection 158 received on the second delivery receiving device 104b was previously picked up by the now empty supply receiving device 172 of the stack storage 156 raised along its displacement path V parallel to the z-direction, i.e., transferred from the supply receiving device 172 to the second delivery receiving device 104b by a transfer movement of the second delivery receiving device 104b.
  • the empty provision receiving device 172 is the third provision receiving device 172 from the top in the stack storage 156.
  • this is located in a provision area 180, in which a transfer of the second subselection 158 from the delivering provision receiving device 172 to the receiving second delivery receiving device 104b is possible.
  • the first transport device 68 can also transport second sub-selections 158 in a transferable manner and the stack storage 156 can convey first sub-selections 157 in a transferable manner.
  • the second receiving device 102 By using the second receiving device 102 with the receiving arrangement 104 comprising the two delivery receiving devices 104a and 104b, a set of laboratory items required to carry out a pipetting task, consisting of source container 158a with the dosing liquid to be pipetted held therein, pipetting tip arrangement 158b with eight disposable pipetting tips 184 each and the microtiter plate 158c as a source container, can only be configured in the working area 186 of the pipetting device 64.
  • a pipetting process in the working area 186 of the pipetting device 64 of the laboratory work module 56b is shown in Figure 15.
  • the pipetting tip arrangement 158b is provided with eight disposable pipetting tips 184 arranged side by side parallel to the x-direction such that the disposable pipetting tips 184 can be coupled to the eight pipetting channels 92, which are also arranged side by side parallel to the x-direction.
  • a coupling longitudinal end 184a is provided pointing toward the longitudinal end of the pipetting channel 92.
  • the second sub-selection 158 is first moved into the working area 186 of the pipetting device 64 so that the pipetting device 64 can couple the disposable pipetting tips 184 of a pipetting tip arrangement 158b to the pipetting channels 92. Subsequently, a source container 158a is moved below the dispensing openings of the coupled disposable pipetting tips 184 so that the pipetting device 64 can aspirate dispensing liquid from the source container 158a.
  • the microtiter plate 158c is moved beneath the disposable pipetting tips 184 received on the pipetting channels 92, so that the pipetting device 64 can dispense dosing liquid aspirated into the disposable pipetting tips 184 into individual wells 188 of the microtiter plate 158c.
  • the wells 188 are arranged in a matrix-like manner in the microtiter plate 158c in a known manner, in the example shown in an 8 x 12 matrix. Therefore, dosing liquid can be dispensed simultaneously, row by row, into one of the twelve well rows of eight wells 188 each.
  • the disposable pipetting tips 184 can be returned to their delivery receptacle and decoupled from the pipetting channels 92.
  • disposable pipetting tips 184 can be ejected from the pipetting channels into a waste container through the opening 130 or through another opening in the base plate 90.
  • the waste container can be provided in a laboratory base module 42b arranged below the laboratory work module 56b.
  • the second transport device 96 can be moved one row spacing between two dispensings so that a subsequent dispensing can be performed into a new row of eight wells 188.
  • the microtiter plate 158c now filled with dosing liquid, can be transported by the second transport device 96 by means of the first delivery-receiving device 104a and by the first transport device 68 into another laboratory work module 56b, for example into a laboratory work module 56a with an incubator 58.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention se rapporte à un module de laboratoire (56) comprenant un dispositif de transport de distribution (96), qui peut être déplacé le long d'un trajet de transport de distribution (98), pour transporter au moins un objet de laboratoire (158a, 158b, 158c) à l'intérieur du module de laboratoire (56) le long du trajet de transport de distribution (98), ledit dispositif de transport de distribution (96) ayant un ensemble de réception de distribution (104) conçu pour recevoir au moins un objet de laboratoire (158a, 158b, 158c). Selon l'invention, l'ensemble de réception de distribution (104) comporte deux dispositifs de réception de distribution (104a, 104b), dont chacun est conçu pour recevoir un objet de laboratoire (158a, 158b, 158c) respectif pour un processus de transport réalisé au moyen du dispositif de transport de distribution (96), les deux dispositifs de réception de distribution (104a, 104b) pouvant être déplacés ensemble le long du trajet de transport de distribution (98).
PCT/EP2025/050931 2024-01-17 2025-01-15 Module de laboratoire comprenant un dispositif de transport de distribution avec deux dispositifs de réception de distribution, chacun étant conçu pour recevoir au moins un objet de laboratoire respectif Pending WO2025153557A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102024101357.5A DE102024101357A1 (de) 2024-01-17 2024-01-17 Labormodul mit einer Liefer-Transportvorrichtung mit zwei Liefer-Aufnahmeeinrichtungen zur Aufnahme von je wenigstens einem Laborgegenstand
DE102024101357.5 2024-01-17

Publications (1)

Publication Number Publication Date
WO2025153557A1 true WO2025153557A1 (fr) 2025-07-24

Family

ID=94383583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2025/050931 Pending WO2025153557A1 (fr) 2024-01-17 2025-01-15 Module de laboratoire comprenant un dispositif de transport de distribution avec deux dispositifs de réception de distribution, chacun étant conçu pour recevoir au moins un objet de laboratoire respectif

Country Status (2)

Country Link
DE (1) DE102024101357A1 (fr)
WO (1) WO2025153557A1 (fr)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0856736A2 (fr) 1997-01-29 1998-08-05 Hitachi, Ltd. Dispositif pour analyses automatisées
EP0990906A1 (fr) 1998-09-28 2000-04-05 F. Hoffmann-La Roche Ag Dispositif de transport de composants dans un système d'analyses automatisé
US20060216207A1 (en) * 2005-03-22 2006-09-28 Applera Corporation Dual nest microplate spotter
EP2022736A1 (fr) 2006-05-16 2009-02-11 Rorze Corporation Dispositif de transport de type navette, dispositif d'alimentation et de collecte de microplaque, dispositif de retrait de microplaque, cassette de microplaque et tablette destinée à recevoir une microplaque
EP2664925A1 (fr) * 2012-05-15 2013-11-20 Aoi Seiki Co., Ltd. Dispositif de bâti de réception
DE202016102244U1 (de) * 2016-04-27 2016-05-17 Analytik Jena Ag Vorrichtung zur Führung und Zustellung einer Mikroplatte zu mehreren Handhabungsplätzen entlang einer Linearführung
CA3031468A1 (fr) * 2016-07-21 2018-01-25 Siemens Healthcare Diagnostics Inc. Systeme d'analyseur clinique automatise et procede
EP3450985A1 (fr) 2017-08-31 2019-03-06 Tecan Trading Ag Appareil de traitement de microdisques
US20200191808A1 (en) * 2014-07-28 2020-06-18 Douglas Scientific, LLC Instrument for analyzing biological samples and reagents
AU2022261457A1 (en) * 2021-04-22 2023-11-09 Arteion System for treating biological samples, comprising a system for conveying holders for biological sample containers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016103639A1 (de) * 2016-03-01 2017-09-07 Andreas Hettich Gmbh & Co. Kg Zuführvorrichtung

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0856736A2 (fr) 1997-01-29 1998-08-05 Hitachi, Ltd. Dispositif pour analyses automatisées
EP0990906A1 (fr) 1998-09-28 2000-04-05 F. Hoffmann-La Roche Ag Dispositif de transport de composants dans un système d'analyses automatisé
US20060216207A1 (en) * 2005-03-22 2006-09-28 Applera Corporation Dual nest microplate spotter
EP2022736A1 (fr) 2006-05-16 2009-02-11 Rorze Corporation Dispositif de transport de type navette, dispositif d'alimentation et de collecte de microplaque, dispositif de retrait de microplaque, cassette de microplaque et tablette destinée à recevoir une microplaque
US7954624B2 (en) 2006-05-16 2011-06-07 Rorze Corporation Shuttle type conveying device, microplate feeding and collecting device, pickup device for microplate, cassette for microplate, and shelf for containing microplate
EP2664925A1 (fr) * 2012-05-15 2013-11-20 Aoi Seiki Co., Ltd. Dispositif de bâti de réception
US20200191808A1 (en) * 2014-07-28 2020-06-18 Douglas Scientific, LLC Instrument for analyzing biological samples and reagents
DE202016102244U1 (de) * 2016-04-27 2016-05-17 Analytik Jena Ag Vorrichtung zur Führung und Zustellung einer Mikroplatte zu mehreren Handhabungsplätzen entlang einer Linearführung
CA3031468A1 (fr) * 2016-07-21 2018-01-25 Siemens Healthcare Diagnostics Inc. Systeme d'analyseur clinique automatise et procede
EP3450985A1 (fr) 2017-08-31 2019-03-06 Tecan Trading Ag Appareil de traitement de microdisques
AU2022261457A1 (en) * 2021-04-22 2023-11-09 Arteion System for treating biological samples, comprising a system for conveying holders for biological sample containers

Also Published As

Publication number Publication date
DE102024101357A1 (de) 2025-07-17

Similar Documents

Publication Publication Date Title
US8119080B2 (en) Interlacing pipette or dispenser tips in a liquid handling system
DE69818702T2 (de) Arbeitsgerät zur analyse
EP2022736B1 (fr) Dispositif de transport de type navette, dispositif d'alimentation et de collecte de microplaque, dispositif de retrait de microplaque, cassette de microplaque et tablette destinée à recevoir une microplaque
EP1496365B1 (fr) Dispositif et procédé de transport d'objets
EP1353753B1 (fr) Dispositif de retenue
EP2696205B1 (fr) Lecteur de plaque microtitre avec lève-couvercle pour plaques microtitres
EP3435091B1 (fr) Dispositif d'analyse automatique
DE29720432U1 (de) Roboter
EP1829613A1 (fr) Unité de stockage et système de transfert destinés au stockage et la préparation d'échantillons biologiques
DE3841961A1 (de) Geraet zur analyse von physiologischen oder anderen fluessigkeiten in den vertiefungen einer mikrotestplatte
JP2019078744A (ja) ラック位置決めシステム
DE202010012318U1 (de) Vorrichtung zur Lagerung und Bereitstellung von Objekten mit standardisierten Abmaßen
EP1836291A1 (fr) Dispositif de stockage automatique et armoire climatique pour articles de laboratoire
WO2020120567A1 (fr) Automate de laboratoire pour la manipulation automatique d'échantillons de laboratoire
JP2003034407A (ja) 自動倉庫設備並びにこれに使用するトレー
WO2025153557A1 (fr) Module de laboratoire comprenant un dispositif de transport de distribution avec deux dispositifs de réception de distribution, chacun étant conçu pour recevoir au moins un objet de laboratoire respectif
DE69901808T2 (de) Automatisches gerät zur erzeugung von proben zur durchführung chemischer oder biologischer reaktionen im flüssigen milieu
DE102024101354A1 (de) Pipettier-Labormodul mit besonderer Beschickung der Pipettiervorrichtung des Pipettier-Labormoduls
DE102024101352A1 (de) Labormodul mit einander einen Transportgegenstand abstreifend übergebenden Transportvorrichtungen
DE102024101358A1 (de) Labormoduletagere aus übereinander angeordneten Labormodulen
DE4329791C2 (de) Verfahren zur automatischen Verteilung und zum Transport von Mikrofilterscheiben
DE102023115855B4 (de) Lagerlift mit automatischer Beladung und Entladung durch ein Fahrzeug
EP1060396A1 (fr) Procede et dispositif pour realiser un grand nombre d'essais biologiques/chimiques identiques a une petite echelle
US20250258190A1 (en) Multiple lane extraction drawer and plate sealer
EP2385101B1 (fr) Incubateur dotée de plusieurs stations d'entrée et muni de moyen de transport

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 25701357

Country of ref document: EP

Kind code of ref document: A1