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WO2025151277A1 - Systèmes d'imagerie comprenant des réseaux de lumière et des diffuseurs et procédés associés - Google Patents

Systèmes d'imagerie comprenant des réseaux de lumière et des diffuseurs et procédés associés

Info

Publication number
WO2025151277A1
WO2025151277A1 PCT/US2024/061402 US2024061402W WO2025151277A1 WO 2025151277 A1 WO2025151277 A1 WO 2025151277A1 US 2024061402 W US2024061402 W US 2024061402W WO 2025151277 A1 WO2025151277 A1 WO 2025151277A1
Authority
WO
WIPO (PCT)
Prior art keywords
equal
container
drawer
light
diffuser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/061402
Other languages
English (en)
Inventor
Christian Hansel
Zichao BIAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Charles River Laboratories International Inc
Original Assignee
Charles River Laboratories International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charles River Laboratories International Inc filed Critical Charles River Laboratories International Inc
Publication of WO2025151277A1 publication Critical patent/WO2025151277A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/255—Details, e.g. use of specially adapted sources, lighting or optical systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/88—Investigating the presence of flaws or contamination
    • G01N21/8806—Specially adapted optical and illumination features
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/02—Diffusing elements; Afocal elements
    • G02B5/0273—Diffusing elements; Afocal elements characterized by the use
    • G02B5/0278—Diffusing elements; Afocal elements characterized by the use used in transmission
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/51—Housings
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/54—Mounting of pick-up tubes, electronic image sensors, deviation or focusing coils
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/55—Optical parts specially adapted for electronic image sensors; Mounting thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06126—Large diffuse sources

Definitions

  • Disclosed embodiments are related to imaging systems including light arrays and diffusers, for example, for quantifying microorganism colonies.
  • FIG. 2B is a schematic diagram illustrating a perspective view of a drawer and additional components of an imaging system in an open configuration, according to some embodiments
  • Quality control is desirable in various fields to monitor and prevent the contamination of samples, products, water, etc.
  • Conventional systems and methods for performing quality control involve manually positioning containers (e.g., petri dishes) containing samples within the system, followed by analysis comprising manual counting methods. Such manual methods may introduce error during analysis of samples based on variations in the lighting source and associated bias from the counting methods.
  • conventional systems include drawers to automatically position a container therein. The use of such drawers, however, may interfere with the use of conventional lighting configurations that transmit light from the bottom of the container to the top of the container during imaging, as the drawer may be made from an optically opaque material.
  • the receptacle may be configured to receive a container, as described in more detail elsewhere herein.
  • a material that is at least partially transparent may form a portion of the receptacle in order to allow light to pass from the array of light sources, through the drawer (e.g., through the at least partially transparent portion of the receptacle), to transmit the light through the bottom of the container to the top of the container towards the photosensitive detector.
  • the at least partially transparent portion of the receptacle may be a diffuser, as described in more detail below.
  • the imaging systems described herein may facilitate the use of drawers for automatic positioning of a container while also incorporating traditional light sources that transmit through a container, e.g., from the bottom of the container to the top of the container, towards a photosensitive detector during an imaging process.
  • the at least partially transparent material of the drawer is a diffuser and may form a base of a receptacle of the drawer that a container is disposed on during imaging. Accordingly, in some such embodiments, the container containing the sample may be disposed on top of the diffuser, relative to a direction of gravity, when the container is present in the drawer of the imaging system.
  • the use of a diffuser in some embodiments, may be desirable for further providing more uniform light from the light sources, as the more uniform light transmitted through the diffuser is transmitted towards and through the container disposed in the drawer towards a photosensitive detector disposed on an opposing side of the container during imaging.
  • the use of a diffuser as a portion of the receptacle of the drawer may facilitate improved imaging of the container and subsequent analysis of any collected images by allowing for the use of the automated drawer while coupling with a conventional light source that transmits light through at least a portion of the drawer (e.g., the diffuser) towards a base of the container.
  • the uniform lighting of the container in the imaging system may provide more uniform and more reproducible lighting conditions when imaging different locations in a single sample and/or when imaging different samples. This may help to minimize errors associated with comparing images collected from different locations and/or different samples that may be subject to different lighting conditions within an imaging system.
  • the drawer may be configured to slide at least partially in and out of a housing of the imaging system between an open and closed configuration. For example, in some embodiments, sliding the drawer out of the housing of the imaging system results in the drawer moving from the closed configuration towards the open configuration.
  • a receptacle of the drawer may be accessible by a user in order to place a container containing a sample into the receptacle.
  • Alignment along the optical path indicates that light from the light sources may pass through a portion of the drawer within the field of view of the photosensitive detector, thus light transmitted through the drawer (e.g., and/or a container disposed therein) may pass towards the photosensitive detector to be collected during imaging. Accordingly, when in the closed configuration, the drawer may position the drawer appropriately to facilitate imaging of a container disposed in a receptacle of the drawer. Correspondingly, when in the open configuration, the receptacle may be misaligned with the optical path.
  • imaging systems described herein may provide uniform lighting that may be beneficial for improving quality control methods, for example, by providing reproducible conditions and/or minimizing and/or eliminating bias associated with variations in lighting when performing various analysis methods. Additionally, the imaging systems and related methods may be useful in a variety of other applications that utilize imaging systems. Non-limiting examples of different fields in which such an imaging system may be advantageous include histopathology, micro total analysis systems, electronics, biotechnology, mineralogy, and microbiology, all of which may involve the imaging (e.g., optical imaging) of at least partially optically transparent samples to evaluate a property of the sample.
  • imaging e.g., optical imaging
  • the plurality of light sources may form an array with any of a variety of layouts including a regular and/or periodic array with a circular, ovular, triangular, square, rectangular, pentagonal, hexagonal, or any other regular polygonal layout.
  • the layout of the array of the plurality of light sources may be irregular. In either case, the disclosed arrangements may facilitate the delivery of uniform light intensity from the plurality of light sources to the different areas of a field of view of an associated photosensitive detector of the imaging system.
  • the number of light sources present in an array of light sources may depend on various other parameters of the imaging system, for example, the size and intensity of the light sources, the desired spacing of the light sources, the size of the container (e.g., and/or sample disposed therein) received by the imaging system, and/or a corresponding field of view of a photosensitive detector used to image the container.
  • the number of light sources present in the plurality of light sources is less than or equal to 1000, less than or equal to 500, less than or equal to 300, less than or equal to 200, less than or equal to 170, less than or equal to 150, less than or equal to 130, less than or equal to 110, less than or equal to 96, less than or equal to 90, less than or equal to 70, less than or equal to 50, less than or equal to 30, or less than or equal to 20 light sources. Combinations of the foregoing ranges are possible (e.g., greater than or equal to 10 and less than or equal to 1,000 light sources). Other ranges are also possible.
  • each light source in the plurality of light sources may have an average maximum dimension of greater than or equal to 15 microns, greater than or equal to 25 microns, greater than or equal to 50 microns, greater than or equal to 100 microns, greater than or equal to 200 microns, greater than or equal to 300 microns, greater than or equal to 500 microns, greater than or equal to 750 microns, greater than or equal to 1 mm, greater than or equal to 2 mm, greater than or equal to 3 mm, or greater than or equal to 4 mm.
  • Each of the light sources of the plurality of light sources may be configured to emit light continuously at a maximum average radiant intensity, according to some embodiments.
  • the average maximum radiant intensity may depend on any of a variety of parameters, for example, the type of light source, the size of the light source, and/or the power input when using the light source.
  • the plurality of light sources and diffuser may be configured to emit light directed at a container in a drawer of an imaging system with a desired areal intensity.
  • the average areal radiance of the light emitted from the plurality of light sources and transmitted through the diffuser to a container may be greater than or equal to 1 mW/(sr m 2 ), greater than or equal to 10 mW/(sr m 2 ), greater than or equal to 50 mW/(sr m 2 ), greater than or equal to 100 mW/(sr m 2 ), greater than or equal to 500 mW/(sr m 2 ), greater than or equal to 1 W/(sr m 2 ), or greater than or equal to 10 W/(sr m 2 ).
  • the average areal radiance of the light emitted from the plurality of light sources and transmitted through the diffuser is less than or equal to 10 W/(sr m 2 ), less than or equal to 1 W/(sr m 2 ), less than or equal to 500 mW/(sr m 2 ), less than or equal to 100 mW/(sr m 2 ), less than or equal to 50 mW/(sr m 2 ), or less than or equal to 10 mW/(sr m 2 ). Combinations of the foregoing ranges are possible (e.g., greater than or equal to 1 mW/(sr m 2 ) and less than or equal to 10 W/(sr m 2 )). Other ranges are also possible.
  • a diffuser used in any of the embodiments disclosed herein may have an appropriate transmittance to provide a desired level of illumination to a container disposed in a receptacle of a drawer.
  • a diffuser may have a transmittance that is greater than or equal to 50%, greater than 60%, greater than or equal to 70%, greater than or equal to 80%, greater than or equal to 90%, greater than or equal to 95%, or any other appropriate transmittance.
  • the plurality of light sources may have appropriate spacings within a regular or irregular array.
  • a center-to- center spacing of adjacent light sources in the plurality of light sources may be greater than or equal to 20 microns, greater equal to 50 microns, greater than or equal to 100 microns, greater than or equal to 250 microns, greater than or equal to 500 microns, greater than or equal to 1 mm, greater than or equal to 2 mm, greater than or equal to 3 mm, greater than or equal to 5 mm, greater than or equal to 10 mm, greater than or equal to 12.5 mm, or greater than or equal to 15 mm.
  • the light emitted from a light source may correspond to the nearultraviolet (e.g., greater than or equal to 300 nm and less than or equal to 400 nm), visible (e.g., greater than or equal to 400 nm and less than or equal to 800 nm), near-infrared (e.g., greater than or equal to 800 nm and less than or equal to 1400 nm), and/or infrared wavelength ranges (e.g., greater than or equal to 1400 nm and less than 1mm).
  • the wavelengths emitted by the light sources may be selected in accordance with the desired application. For example, light sources that emit light having wavelengths that correspond to visible light may be selected for optical imaging. It may be advantageous to use different types of light sources based on the application and/or the desired application.
  • the wavelength(s) of light emitted by the light sources of the plurality of light sources is greater than or equal to 300 nm, greater than or equal to 400 nm, greater than or equal to 500 nm, greater than or equal to 600 nm, greater than or equal to 700 nm, greater than or equal to 800 nm, greater than or equal to 900 nm, greater than or equal to greater than or equal to 1000 nm, or greater than or equal to 1250 nm.
  • the wavelength(s) of light emitted by the light sources of the plurality of light sources is less than or equal to 1400 nm, less than or equal to 1250 nm, less than or equal to 1000 nm, less than or equal to 900 nm, less than or equal to 800 nm, less than or equal to 700 nm, less than or equal to 600 nm, less than or equal to 500 nm, or less than or equal to 400 nm. Combinations of the foregoing ranges are possible (e.g., greater than or equal to 300 nm and less than or equal to 1400 nm, greater than or equal to 400 nm and less than or equal to 800 nm, etc.). Other ranges are also possible.
  • Example materials that may be suitable for use in or as a diffuser in the imaging systems include, but are not limited to, acrylic, ground glass, various polymeric materials (e.g., polymethylmethacrylate, silicone), and metal oxides (e.g., as particles that may scatter light; TiCh, ZnO, etc.). Additionally, a diffuser may include appropriate surface features to help provide the desired amount of light diffusion.
  • the diffuser transmits at least a portion of the light that is emitted from the plurality of light sources.
  • the amount of light transmitted through the diffuser may be determined by illuminating a light source with and without a diffuser in an optical path that passes from the light source to an associated photosensitive detector.
  • the diffuser transmits greater than or equal to 30%, greater than or equal to 35%, greater than or equal to 40%, greater than or equal to 45%, greater than or equal to 50 %, greater than or equal to 60%, greater than or equal to 65%, greater than or equal to 70%, greater than or equal to 75%, greater than or equal to 80%, greater than or equal to 85%, greater than or equal to 90%, greater than or equal to 95% of the light emitted from the plurality of light sources and that is directed towards the diffuser.
  • the light transmitted through the diffuser from the plurality of light sources may be uniform, in accordance with some embodiments.
  • light may be transmitted from the plurality of light sources, through the diffuser, and then detected at an associated photosensitive detector.
  • the light detected at the photosensitive detector e.g., the light frequency being detected, corresponding to the light wavelengths as described elsewhere herein
  • the diffuser may have a low variance when compared to an average intensity of the light within a field of view of a photosensitive detector located on an opposing side of a diffuser relative to the plurality of lights.
  • the variance of the intensity of light between adjacent light sources in a field of view of the photosensitive detector from the average intensity of light detected in the field of view by the associated photosensitive detector is less than or equal to 10%, less than or equal to 9%, less than or equal to 8%, less than or equal to 7%, less than or equal to 6%, less than or equal to 5%, less than or equal to 4%, less than or equal to 3%, or less than or equal to 2% of the detected average intensity of the light.
  • the variance of the intensity of light between adjacent light sources in a field of view of the photosensitive detector from the average intensity of light in the field of view detected by the associated photosensitive detector is greater than or equal to 1%, greater than or equal to 2%, greater than or equal to 3%, greater than or equal to 4%, greater than or equal to 5%, greater than or equal to 6%, greater than or equal to 7%, greater than or equal to 8%, or greater than or equal to 9% of the detected average intensity of the light. Combinations of the foregoing ranges are possible (e.g., greater than or equal to 1% and less than or equal to 10%, greater than or equal to 5% and less than or equal to 10%). Other ranges are also possible.
  • the above noted average and variances associated with the light intensities of a field of view of the photosensitive detector may be evaluated using the light intensities measured by the photosensitive detector without a container presented in the imaging system and other potentially blocking systems located outside the field of view of the photosensitive detector.
  • the imaging system 100 may further include a container (e.g., containing a sample) disposed in the receptacle 106 of the drawer 105 of the imaging system 100, e.g., on a diffuser 110 forming a portion of the receptacle 106.
  • the imaging system when the container is present in the receptacle 106, the imaging system may be configured to align the container along the optical path between the plurality of light sources 120 and the photosensitive detector when the imaging system is in the closed configuration. For example, referring again to FIG. 1C, when a container 145 is present, it may be positioned vertically above diffuser 110 of the drawer along optical path 140.
  • each dimension (e.g., a width, length, and/or height) of the cutout may independently be less than or equal to 3 cm, less than or equal to 2 cm, or less than or equal to 1 cm. Combinations of the foregoing ranges are possible (e.g., greater than or equal to 5 mm and less than or equal to 3 cm). Other ranges are also possible.
  • the cutouts 112 facilitate the placement and removal of a container from the receptacle 106 of the imaging system 100, thereby making the imaging system 100 more user friendly relative to conventional systems where such cutouts 112 are absent.
  • the container may be a petri dish, and removal of the petri dish from the receptacle 106 may be difficult in the absence of the cutouts 112, and thus the presence of the cutouts 112 functionally improves the ability of the user to insert and/or remove a container from the receptacle 106 of the drawer 105.
  • the method may comprise positioning a container in a receptacle 106 of the drawer 105.
  • method 300 comprises positioning a container containing a sample above a diffuser 110 in a receptacle 106 of a drawer 105 relative to a direction of gravity 320.
  • a container containing a sample such as a petri dish containing microorganisms, may be positioned within the receptacle 106 of the drawer 105 of the imaging system 100 while the system is in its open configuration, as shown in FIG. 2A.
  • the container may be positioned on the diffuser 110 due to the diffuser forming at least a portion of, or the entire, base of the receptacle 106. Accordingly, positioning the container in the receptacle 106 of the drawer 105 may include positioning the container over and/or on the diffuser 110 of the drawer 105.
  • the method may further include displacing the drawer 105 into the housing 102 of the imaging system 100 such that the receptacle 106 and container disposed therein are positioned along an optical path between a plurality of light sources 120 and a photosensitive detector at 330.
  • displacing the drawer 105 into the housing 102 to the closed configuration positions the receptacle 106, container disposed therein, and diffuser 110 in alignment with the optical path between the plurality of light sources 120 and the photosensitive detector 150.
  • the method 300 may further include illuminating the container.
  • the method 300 includes transmitting light from the plurality of light sources 120 through the diffuser 110 and through at least a portion of the container towards a photosensitive detector at 340.
  • light emitted from the plurality of light sources 120 may follow an optical path to the photosensitive detector, as shown in FIG. 1A.
  • the method 300 includes transmitting light radially inwards from a ring light 130 towards at least a portion of the container such that the illuminated sample may be imaged by the photosensitive detector at 350.
  • the sample contained in the container may be imaged or otherwise sensed using a photosensitive detector at 360.
  • the image, images, or other signals collected by the photosensitive detector may be subjected to any appropriate type of analysis at 370.
  • the photosensitive detector may be configured to collect images of the container and sample disposed therein.
  • the photosensitive detector may be configured to measure an intensity of the light transmitted through the container and sample disposed therein as a function of wavelength. Accordingly, depending on the information gathered by the photosensitive detector, analysis of the resulting data may vary.
  • the diffuser of the imaging system facilitated a similar light spectrum as shown in FIG. 4 at different locations of the sample when illuminated by the plurality of light sources.

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Multimedia (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Signal Processing (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Certains aspects de la présente divulgation concernent généralement des systèmes d'imagerie comprenant une pluralité de sources de lumière et un diffuseur associé à un réceptacle d'un tiroir pour recevoir un récipient pour fournir une source de lumière uniforme pour éclairer le récipient. Le système d'imagerie peut être conçu de telle sorte qu'un trajet optique le long duquel la lumière provenant de la pluralité de sources de lumière se transmet passe à travers le diffuseur et le récipient vers un détecteur photosensible du système d'imagerie lorsque le tiroir est dans une configuration fermée.
PCT/US2024/061402 2024-01-12 2024-12-20 Systèmes d'imagerie comprenant des réseaux de lumière et des diffuseurs et procédés associés Pending WO2025151277A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463620457P 2024-01-12 2024-01-12
US63/620,457 2024-01-12

Publications (1)

Publication Number Publication Date
WO2025151277A1 true WO2025151277A1 (fr) 2025-07-17

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ID=96387489

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Application Number Title Priority Date Filing Date
PCT/US2024/061402 Pending WO2025151277A1 (fr) 2024-01-12 2024-12-20 Systèmes d'imagerie comprenant des réseaux de lumière et des diffuseurs et procédés associés

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Country Link
WO (1) WO2025151277A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5572286A (en) * 1994-06-01 1996-11-05 Fuji Photo Optical Co., Ltd. Head for a color enlarger
WO2010080016A1 (fr) * 2009-01-12 2010-07-15 Karla Dinora Chavez Quiroz Dispositif et procédé d'évaluation de la torréfaction du café
US20130319902A1 (en) * 2011-02-16 2013-12-05 Osvaldo Tufi Blister holder provided with means designed to detect the number of extracted products from the blister and with gsm/gprs communication means to remotely dialogue with a control center
US20200027146A1 (en) * 2017-02-06 2020-01-23 Lego A/S Electronic ordering system and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5572286A (en) * 1994-06-01 1996-11-05 Fuji Photo Optical Co., Ltd. Head for a color enlarger
WO2010080016A1 (fr) * 2009-01-12 2010-07-15 Karla Dinora Chavez Quiroz Dispositif et procédé d'évaluation de la torréfaction du café
US20130319902A1 (en) * 2011-02-16 2013-12-05 Osvaldo Tufi Blister holder provided with means designed to detect the number of extracted products from the blister and with gsm/gprs communication means to remotely dialogue with a control center
US20200027146A1 (en) * 2017-02-06 2020-01-23 Lego A/S Electronic ordering system and method

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