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WO2025150098A1 - Dispositif de mesure non invasif - Google Patents

Dispositif de mesure non invasif

Info

Publication number
WO2025150098A1
WO2025150098A1 PCT/JP2024/000205 JP2024000205W WO2025150098A1 WO 2025150098 A1 WO2025150098 A1 WO 2025150098A1 JP 2024000205 W JP2024000205 W JP 2024000205W WO 2025150098 A1 WO2025150098 A1 WO 2025150098A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
excitation light
optical system
skin tissue
objective lens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2024/000205
Other languages
English (en)
Japanese (ja)
Inventor
若峰 郭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Healthcare Vision Co Ltd
Original Assignee
Healthcare Vision Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Healthcare Vision Co Ltd filed Critical Healthcare Vision Co Ltd
Priority to PCT/JP2024/000205 priority Critical patent/WO2025150098A1/fr
Publication of WO2025150098A1 publication Critical patent/WO2025150098A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Definitions

  • the present invention relates to a non-invasive measurement device.
  • US Patent No. 5,999,633 discloses spatially offset Raman spectroscopy in which incident radiation is provided to an entrance region on the surface of a sample, light scattered within the sample is collected from a collection region on the sample surface spaced apart from the entrance region, and the Raman characteristics of the collected light are detected.
  • the present invention was made in consideration of the above, and aims to accurately measure blood glucose levels from Raman signals.
  • the non-invasive measurement device comprises: A light source unit that emits excitation light; an irradiation optical system that irradiates the skin tissue with the excitation light; a detection optical system for collecting Raman scattered light from the skin tissue; a spectrometer for dispersing the Raman scattered light; an analyzer that measures a blood glucose level by analyzing a spectroscopic signal obtained by the spectrometer; Equipped with The irradiation optical system forms the excitation light into a minute, point-like beam spot, and irradiates the skin tissue with the excitation light at an angle.
  • FIG. 1 is a diagram illustrating a configuration of a non-invasive blood glucose measuring device according to an embodiment of the present invention.
  • 1 is a diagram showing a trajectory of return light on a cross section of a sample when excitation light is incident thereon from a non-invasive blood glucose measuring device according to an embodiment of the present invention.
  • FIG. 2 is a diagram showing return light on a sample surface when excitation light is incident thereon from a non-invasive blood glucose measuring device according to an embodiment of the present invention.
  • FIG. 13 is a diagram showing the light intensity distribution in skin tissue when the incident angle is changed.
  • FIG. 4 is a diagram showing the amount of light detected by a photodetector versus the angle of incidence.
  • FIG. 1 is a diagram showing the configuration of a non-invasive blood glucose measuring device 1.
  • the non-invasive blood glucose measuring device 1 analyzes the concentration of substances contained in skin tissue, etc., based on Raman scattered light generated in a sample 2, which is skin tissue, by irradiation with excitation light.
  • the non-invasive blood glucose measuring device 1 comprises a light source unit 10, an irradiation optical system 11, a detection optical system 12, a spectrometer 13, and an analysis device 14.
  • the light source unit 10 and the irradiation optical system 11 are arranged so that the irradiation light is incident obliquely on the surface of the sample 2.
  • the detection optical system 12 is arranged so that the light is collected from a position on the surface of the sample 2 a predetermined distance away from the position where the irradiation light is incident.
  • the light source unit 10 is a light source that emits excitation light. Since the Raman scattering light generated in the skin tissue 2 by irradiation with excitation light tends to be weak, it is preferable that the light source unit 10 is a light source that emits high-intensity excitation light. Furthermore, since the concentration of glucose contained in the sample 2 is calculated based on the wavelength of the excitation light, it is preferable that the light source unit 10 is a light source that emits excitation light of a single wavelength. Examples of such light sources include semiconductor lasers and solid-state lasers. Furthermore, the light source unit 10 may be an LED (Light Emitting Diode). The wavelength of the excitation light is a single wavelength selected from, for example, 785 nm, 830 nm, 860 nm, and 1064 nm.
  • the ring forming unit 112 is an optical element, for example a ring-shaped light shielding plate, that blocks the central part of the incident excitation light while transmitting the excitation light in the peripheral parts, and forms a ring-shaped beam spot.
  • the spot diameter of the beam spot at the focal position can be made smaller.
  • the ring forming unit 112 may use an axicon lens instead of a light shielding plate. The axicon lens forms the incident excitation light into a ring light by interference.
  • Bandpass filter 113 is a filter that selectively transmits light of a specific wavelength.
  • a specific example of bandpass filter 113 is a laser line filter.
  • a laser line filter is a narrow bandpass filter with the laser wavelength as its center wavelength, and is used to cut the base of the wavelength band of the laser light to sharpen the spectrum of the laser light and reduce background light.
  • the objective lens 114 focuses the ring light formed by the ring forming section 112 to form a tiny beam spot on the surface of the sample 2.
  • the detection optical system 12 is an optical system for collecting Raman scattered light generated by irradiation of the sample 2 with excitation light through the irradiation optical system 11, removing the excitation light, and focusing the light on the spectrometer 13.
  • the detection optical system 12 is disposed at a position on the surface of the sample 2 a predetermined distance away from the position where the excitation light is irradiated from the irradiation optical system 11 to the sample 2, so as to detect Raman scattered light from the dermis layer in the skin tissue of the sample 2.
  • the detection optical system 12 includes an objective lens 120, an edge filter 121, and a focusing lens 122.
  • the Raman scattered light separated from the excitation light and Rayleigh scattered light by the edge filter 121 is focused at the entrance of the spectrometer 13 using another single lens, the focusing lens 122. It is preferable to use a focusing lens 122 with little aberration and an aperture ratio that matches the aperture ratio of the spectrometer 13. This allows the transmitted light to be focused at the entrance of the spectrometer 13 without any omissions.
  • the spectrometer 13 has a spectroscopic element that separates the incident light into wavelengths, and a photodetector 130.
  • the spectroscopic element separates the Raman scattered light supplied from the sample 2 via the detection optical system 12 into wavelengths, and guides the light to the light receiving surface of the photodetector 130.
  • Methods for separating light into wavelengths include, for example, a dispersive spectrometer that uses the diffraction of light, and a Fourier transform spectrometer that uses the coherence of light.
  • a dispersive spectrometer is composed of a collimating mirror, a collecting mirror, and a diffraction grating, and disperses light by using the diffraction and interference caused by the diffraction grating.
  • the analytical device 14 is a computer such as a personal computer, and includes a processor that processes data according to a control program, a main memory that functions as a work area for the processor, and an auxiliary memory for storing data for a long period of time.
  • the analytical device 14 calculates the concentration of glucose contained in the sample 2 based on the spectroscopic signal input from the photodetector 130 of the spectrometer 13.
  • Figures 2A and 2B show the trajectory of return light 32 caused by scattered light generated inside the sample 2 when excitation light irradiated from the non-invasive blood glucose measuring device 1 is incident on the sample 2, with Figure 2A showing a cross section of the sample 2 and Figure 2B showing the surface of the sample 2.
  • the light scattered inside the skin tissue returns to a position on the circumference of the skin surface that is a predetermined radius away from the incident position 33 of the excitation light 31 on the skin surface, which is the skin surface, centered on the incident position 33 of the excitation light 31 on the skin surface. Therefore, if the layer of skin tissue through which the scattered light passes is shallow, the position where the return light 32 is emitted from the skin surface is not so far from the incident position 33. On the other hand, when the layer of skin tissue through which the scattered light passes is deep, the position where the return light 32 is emitted from the skin surface is farther away from the incident position 33 than when the layer of skin tissue through which the scattered light passes is shallow.
  • the scattered light has unique characteristics depending on the substance contained in the layer through which it passes.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Ce dispositif de mesure non invasif comprend : une unité de source de lumière (10) qui émet une lumière d'excitation ; un système optique d'irradiation (11) qui irradie le tissu cutané (2) avec la lumière d'excitation ; un système optique de détection (12) qui collecte la lumière diffusée par effet Raman provenant du tissu cutané (2) ; un spectroscope (13) qui sépare la lumière diffusée par effet Raman ; et un dispositif d'analyse (14) qui analyse un signal spectroscopique obtenu suite à la séparation par le spectroscope de façon à mesurer le taux de glycémie. Le système optique d'irradiation (11) forme la lumière d'excitation en des points de faisceau minuscule dans un motif de points et irradie le tissu cutané (2) obliquement avec la lumière d'excitation.
PCT/JP2024/000205 2024-01-09 2024-01-09 Dispositif de mesure non invasif Pending WO2025150098A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2024/000205 WO2025150098A1 (fr) 2024-01-09 2024-01-09 Dispositif de mesure non invasif

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2024/000205 WO2025150098A1 (fr) 2024-01-09 2024-01-09 Dispositif de mesure non invasif

Publications (1)

Publication Number Publication Date
WO2025150098A1 true WO2025150098A1 (fr) 2025-07-17

Family

ID=96386705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2024/000205 Pending WO2025150098A1 (fr) 2024-01-09 2024-01-09 Dispositif de mesure non invasif

Country Status (1)

Country Link
WO (1) WO2025150098A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6580081B1 (en) * 1999-08-02 2003-06-17 Jena-Optronik Gmbh Arrangement for the detection of fluorescene radiation of matrix-shaped speciman carriers
WO2014178199A1 (fr) * 2013-05-02 2014-11-06 アトナープ株式会社 Dispositif de surveillance et système de surveillance d'organismes vivants
CN106198490A (zh) * 2016-08-17 2016-12-07 中国原子能科学研究院 一种空间偏移拉曼光谱探测系统
US20170003226A1 (en) * 2015-07-03 2017-01-05 Cobalt Light Systems Limited Scanner for spatially offset raman spectroscopy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6580081B1 (en) * 1999-08-02 2003-06-17 Jena-Optronik Gmbh Arrangement for the detection of fluorescene radiation of matrix-shaped speciman carriers
WO2014178199A1 (fr) * 2013-05-02 2014-11-06 アトナープ株式会社 Dispositif de surveillance et système de surveillance d'organismes vivants
US20170003226A1 (en) * 2015-07-03 2017-01-05 Cobalt Light Systems Limited Scanner for spatially offset raman spectroscopy
CN106198490A (zh) * 2016-08-17 2016-12-07 中国原子能科学研究院 一种空间偏移拉曼光谱探测系统

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