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WO2025149370A1 - Sous-ensemble d'un dispositif d'administration de médicament - Google Patents

Sous-ensemble d'un dispositif d'administration de médicament

Info

Publication number
WO2025149370A1
WO2025149370A1 PCT/EP2024/088220 EP2024088220W WO2025149370A1 WO 2025149370 A1 WO2025149370 A1 WO 2025149370A1 EP 2024088220 W EP2024088220 W EP 2024088220W WO 2025149370 A1 WO2025149370 A1 WO 2025149370A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
container
container driver
sub
directed surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/088220
Other languages
English (en)
Inventor
Johan Zander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHL Medical AG
Original Assignee
SHL Medical AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHL Medical AG filed Critical SHL Medical AG
Publication of WO2025149370A1 publication Critical patent/WO2025149370A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3234—Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user
    • A61M2005/3235—Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user triggered by radial deflection of the anchoring parts between needle mount and syringe barrel or needle housing, e.g. spreading of needle mount retaining hooks having slanted surfaces by engagement with correspondingly shaped surfaces on the piston at the end of an injection stroke
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback

Definitions

  • the present disclosure generally relates to a sub-assembly of a medicament delivery device, and particularly to a sub-assembly of a medicament delivery device comprising a container driver.
  • Medicament delivery devices such as pen-type manual injectors or auto-injectors are generally known for the self-administration of a medicament by patients without formal medical training.
  • patients suffering from diabetes may require repeated injections of insulin, or patients may require regular injections of other types of medicaments, such as growth hormones.
  • the medicament delivery devices for self-administration comprise automatic functions so that even if users are without professional training or are in an emergency, the users can easily and properly use the medicament delivery devices.
  • distal direction refers to the direction pointing away from the dose delivery site during the use of the medicament delivery device.
  • distal part/end refers to the part/end of the delivery device, or the parts/ends of the members thereof, which under use of the medicament delivery device is/are located furthest away from the dose delivery site.
  • proximal direction refers to the direction pointing towards the dose delivery site during the use of the medicament delivery device.
  • proximal part/end this refers to the part/end of the delivery device, or the parts/ends of the members thereof, which under use of the medicament delivery device is/are located closest to the dose delivery site.
  • longitudinal refers to a direction extending from the proximal end to the distal end, typically along the device or components thereof in the direction of the longest extension of the device and/or component.
  • transverse refers to a direction generally perpendicular to the longitudinal direction.
  • circumference refers to a circumference or a circumferential direction relative to an axis, typically a central axis extending in the direction of the longest extension of the device and/or component.
  • radial refers to a direction extending radially relative to the axis
  • rotation refers to rotation relative to the axis.
  • a sub-assembly of a medicament delivery device comprising: a housing extending along a longitudinal axis between a proximal end and a distal end; wherein the housing comprises a proximally directed surface; a plunger rod accommodated with the housing; wherein the plunger rod comprises a body configured to be moved into a medicament container of the medicament delivery device; a container driver configured to operably engaged to the medicament container such that the medicament container is immovable relative to the container drive in the direction of the longitudinal axis; wherein the container driver comprises a flexible section comprising a distally directed surface; wherein the container driver is positioned between the plunger rod and the housing in a direction transverse to the longitudinal axis; a biasing member configured to be operably connected to the medicament container to bias the medicament container towards the distal end of the housing.
  • the plunger rod is movable along the longitudinal axis relative to the container driver between a distal position where the flexible section of the container driver is radially deflected by the body of the plunger rod such that the distally directed surface of the container driver is engaged with the proximally directed surface of the housing and a proximal position where the body of the plunger rod is disengaged from the flexible section of the container driver such that the distally directed surface of the container driver is disengaged with the proximally directed surface of the housing thereby the biasing member can bias the medicament container towards the distal end of the housing.
  • the sub-assembly comprises a container carrier configured to accommodate the medicament container of the medicament delivery device.
  • the container driver is snapped fit to the container carrier.
  • the biasing member is a spring extending between a first end and a second in the direction of the longitudinal axis.
  • the spring is a compression spring or a tension spring.
  • the housing comprises an inner housing sleeve.
  • the container driver is positioned within the inner housing sleeve.
  • a recess/cut-out is arranged in the body of the plunger rod.
  • an edge of the recess/cut-out comprises the proximally directed surface of the plunger rod.
  • the housing comprises a wall facing towards the longitudinal axis; wherein the wall comprises a proximal section and a distal section closer to the longitudinal axis than the proximal section; and wherein an edge of the distal section adjacent to the proximal section comprises the proximally directed surface of the housing.
  • the container driver is configured to be moved towards the proximal end of the housing from the first position to the second position thereby causing the biasing member to accumulate more energy via the medicament container.
  • Another aspect of the presented invention provides a sub-assembly of a medicament delivery device, the sub-assembly comprises the component according to any one of the proceeding embodiments; wherein the sub-assembly comprises a button comprising a user-accessible section and a flexible arm extending from the user-accessible section; wherein the flexible arm comprises a distally directed surface configured to be moved along one of the first chamfered surface and the second chamfered surface and a proximally directed surface configured to be moved along the other one of the first chamfered surface and the second chamfered surface.
  • the distally directed surface of the flexible arm is configured to be moved along the second chamfered surface; and wherein the proximally directed surface of the flexible arm is configured to be moved along the first chamfered surface.
  • the sub-assembly comprises a housing that accommodates the component and the flexible arm of the button; and wherein the housing is extending along the longitudinal axis between a proximal end and a distal end.
  • the medicament delivery device of any aspect of the presented invention comprises a single-chamber syringe.
  • the syringe is made of glass material or plastic material.
  • the medicament delivery device of any aspect of the presented invention is an injection device, an inhalation device, or a medical sprayer.
  • the medicament delivery device of any aspect of the presented invention is an auto-injector.
  • the delivery member is an injection needle or a spray nozzle.
  • Fig. 2 schematically shows a perspective view of components of the medicament delivery device of Fig. 1 ;
  • Fig. 4 schematically shows a perspective view of a container carrier, biasing member, and a container driver of the sub-assembly of Fig. 3;
  • Figs 5-9 schematically show cross-section views of the sub-assembly of Fig. 3 in different stages;
  • Figs 10-11 schematically show cross-section views of the sub-assembly of Fig. 3 with a button having a proximally extending arm in different stages;
  • Fig. 13-20 schematically show cross-section views of the sub-assembly of Fig. 3 comprising the connector of Fig. 12 in different stages;
  • Fig. 21 schematically shows a perspective view of the sub-assembly of Fig. 3 comprising a cap and a medicament container;
  • Figs 22-23 schematically show perspective views of the connector, the button, and the housing of the sub-assembly of Fig. 13;
  • Figs 25-26 schematically show perspective views of a sub-assembly of another aspect of the presented disclosure having the container driver of Fig. 24.
  • Figs 1-26 illustrate a sub-assembly of a medicament delivery device.
  • the sub-assembly comprises a housing 1 extending along a longitudinal axis L between a proximal end and a distal end.
  • the housing 1 is configured to accommodate a medicament container M of the medicament delivery device.
  • the housing 1 can be shaped to be generally cylindrical, as the medicament container is commonly shaped to be cylindrical, as shown in Fig. 1 , thus, the medicament delivery device can be compact.
  • the housing can be shaped to be generally rectangular, triangular, or oval observing along the longitudinal axis L, so that the housing will not roll on a flat surface.
  • the housing can be shaped in any other suitable shape depending on the design.
  • the sub-assembly comprises a container driver 5 configured to be operably engaged to the medicament container M such that the medicament container M is immovable relative to the container drive in the direction of the longitudinal axis L.
  • the container driver 5 comprises a flexible section 52 comprising a distally directed surface 52a, as shown in Figs 6-7.
  • the container driver 5 is positioned between the plunger rod 6 and the housing 7 in a direction transverse to the longitudinal axis L.
  • the housing 1 comprises the inner housing sleeve 7
  • the container driver 5 is positioned within the inner housing sleeve 7.
  • the sub-assembly comprises a biasing member 8 configured to be operably connected to the medicament container M to bias the medicament container M towards the distal end of the housing 1 .
  • the biasing member 8 is a spring extending between a first end and a second in the direction of the longitudinal axis L. In this example, the spring is engaged with the housing 1 at the first end and engaged with the container driver 5 at the second end.
  • the plunger rod 6 is movable along the longitudinal axis L relative to the container driver 5 between a distal position, as shown in Fig. 7, where the flexible section 52 of the container driver 5 is radially deflected by the body 61 of the plunger rod 6 such that the distally directed surface 52a of the container driver 5 is engaged with the proximally directed surface 71a of the housing 1 and a proximal position, as shown in Fig.
  • the body 61 of the plunger rod 6 is configured to continuously deflect the flexible section 52 of the container driver 5 to keep the container driver 5 engaged with the housing 1 .
  • the container driver 5 cannot retract the medicament container M further into the housing 1 under the force of the biasing member 8.
  • the body 61 of the plunger rod 6 is configured to offset from the flexible section 52 of the container driver 5 such that the body 61 of the plunger rod can no longer deflect the flexible section 52 of the container driver 5.
  • the flexible section 52 flexes back to its original configuration. Therefore, the distally directed surface of the flexible section 52 is disengaged from the housing 1 .
  • the biasing member 8 can move the medicament container M together with the container driver 5 towards the distal end of the housing 1 . In other words, the medicament container M is retracted further into the housing 1 , as shown in Figs 8-9.
  • At least one of the distally directed surface 52a of the container driver 5 and the proximally directed surface 71 a is a chamfered surface.
  • the flexible section 52 of the container driver 5 is positioned at a distal end of a flexible arm extending from a body 50 of the container driver 5.
  • the flexible section of the container driver is positioned at a proximal end of a flexible arm extending from the body of the container driver.
  • the flexible section of the container driver is positioned at an inner surface of a resilient part of the body of the container driver.
  • the container driver is configured to directly engage with the medicament container M.
  • the container driver may comprise a gripping arm configured to engage with a flange of the medicament container.
  • the sub-assembly comprises a container carrier 9 configured to accommodate the medicament container M of the medicament delivery device.
  • the container driver 5 is engaged with the container carrier 9.
  • the gripping arm 51 of the container driver 5 is configured to engage with the container carrier 9, as shown in Fig. 4.
  • the container driver 5 is snapped fit to the container carrier 9, as shown in Fig. 5.
  • the container carrier 9 comprises a body sleeve 90 configured to accommodate the medicament container M, a flange 91 extending from the body sleeve 90 in the direction transverse to the longitudinal axis L.
  • the biasing member 8 is engaged with the flange 91 of the container carrier 9 and a ledge 15 extending from the housing 1 .
  • the plunger rod 6 is configured to be connected to a power source 60 to move the plunger rod 6 into the medicament container M.
  • the power source 60 can be a spring, a pressurized gas canister, or a motor.
  • the power source 60 is a spring, as shown in Fig. 2.
  • the container driver 5 is movable along the longitudinal axis L between a first position where the flexible section 52 of the container driver 5 is enclosed by the distal section 70 of the wall of the housing 1 , as shown in Figs 5- 6, such that the flexible section 52 is blocked from flexing radially outwards thereby the distally directed surface 52a of the container driver 5 is engaged with the proximally directed surface of the plunger rod 6 and a second position where the flexible section 52 of the container driver 5 is lined up with the proximal section 71 of the wall of the housing 1 , as shown in Fig.
  • the container driver 5 is configured to be moved towards the proximal end of the housing 1 from the first position to the second position thereby causing the biasing member 8 to accumulate more energy via the medicament container.
  • the housing 1 comprises a flexible section 12 comprising a protrusion 13 extending towards the longitudinal axis L.
  • the protrusion 13 is configured to be operably engaged with the medicament container M.
  • the sub-assembly comprises a cap 2 removably attached to the proximal end of the housing 1 , as shown in Fig. 1 .
  • the cap 2 comprises a wall adjacent to the flexible section 12 of the housing 1 when the cap is attached to the housing.
  • the cap 2 comprises a main body 20 configured to be gripped by the user of the medicament delivery device.
  • the main body 20 may comprise a gripping facilitating feature, e.g., ribs, a hook, or a rubber over-molding surface.
  • the cap 2 comprises a lid 21 attached at the proximal end of the main body 20.
  • the lid 21 comprises a remover arm 22 extending towards the distal end of the housing 1 .
  • the remover arm 22 comprises a grabber 22a configured to be engaged with a shield configured to cover the medicament delivery member, as shown in Fig. 21 .
  • the cap 2 comprises a curved surface configured to interact with the housing, as shown in Fig. 2.
  • the button 3 comprises a user-accessible section 30 extending out from the housing 1 , as shown in Fig. 1 and Figs 10-11 , and a proximally directed surface 131 configured to be engaged with a second distally directed surface 50a of the container driver 5, as shown in Fig. 11.
  • the proximally directed surface 131 of the button 3 is engaged with a second distally directed surface 50a of the container driver 5 when the container driver 5 is in the second position.
  • the button 3 is configured to prevent the container driver 5 from being moved towards the distal end of the housing 1 when the user of the medicament delivery device presses the button.
  • the button may not be used to push the container driver from the first position to the second position as an above-mentioned example.
  • the button may not engage the container driver when the container driver is in the first position.
  • the body 50 of the container driver 5 extends along a longitudinal axis X between the proximal end and the distal end 150.
  • the container driver 5 comprises a protrusion 151 extending from body 50.
  • the protrusion 151 comprises a first chamfered surface 153 and a second chamfered surface 152.
  • the distal support surface 75 prevents the arm 231 of the button 3 from flexing in the direction transverse to the longitudinal axis L such that the container driver 5 is blocked from moving in the distal direction relative to the housing 1 unless the button 3 is no longer pressed by the user.
  • the container driver 5 moves the button 3 in the distal direction relative to the housing 1 .
  • the protrusion 151 of the container driver 5 deflects the arm 231 of the button 3.
  • the container driver 5 can move relative to the button 3.
  • the medicament delivery device can be more compact.
  • the first and the second chamfered surfaces as mentioned above enable the container driver 5 to move past the rib 231c of the button 3 initially even if the rib 231c of the button 3 is aligned with the distal support surface 75 in the direction transverse to the longitudinal axis L, as shown in Figs 19-20.
  • the second chamfered surface 152 is configured to guide the rib 231c of the button 3 to move along the distal support surface of the housing 1 (the moving direction as shown with arrow T in Fig. 25).
  • the second chamfered surface 152 deflects the arm 231 of the button 3 such that the rib 213c of the button 3 moves past the protrusion 151 of the container driver 5.
  • the first chamfered surface 153 is configured to guide the rib 231c towards the distal support surface 75 of the housing 1 , as shown in Fig. 26.
  • the button 3 is configured to move together with the container driver 5 in the distal direction relative to the housing 1 .
  • the mechanism comprises a control sleeve 10, as shown in Fig. 12.
  • the control sleeve 10 comprises a sleeve body 100 extending in the direction of the longitudinal axis L between a proximal end and a distal end.
  • the control sleeve 10 comprises a distal flange 101 extending from the distal end of the sleeve body 100; a first tab 102 extending from the sleeve body 100 of the control sleeve 10 in the direction of the longitudinal axis L; and a second tab 103 extending from the sleeve body 100 of the control sleeve 10 in the direction of the longitudinal axis L.
  • the first tab 102 directs towards the distal end of the sleeve body 100
  • the second tab 103 directs towards the proximal end of the sleeve body 100.
  • the first tab 102 comprises a protrusion 102a extending away from the longitudinal axis L.
  • the second tab 103 comprises an outward protrusion 103a extending away from the longitudinal axis L, and an inward protrusion 103b extending towards the longitudinal axis L.
  • the mechanism comprises a penetration spring 4 placed on the distal flange 101 of the control sleeve 10 at one end and engaged with a second proximally directed surface 74 of the housing 1 at the other end.
  • the second proximally directed surface 74 extends from the inner housing sleeve 7.
  • the second proximally directed surface 74 extends from a distal end of the inner housing sleeve 7.
  • the protrusion 102a of the first tab 102 is configured to be operably engaged with the housing 1 such that the control sleeve 10 is held against the penetration spring 4 by the housing 1.
  • the protrusion 102a of the first tab 102 is engaged with a ledge 72 of the housing 1.
  • the housing 1 comprises the inner housing sleeve 7
  • the ledge is extending from the inner housing sleeve 7, as shown in Fig. 13.
  • the button 3 comprises the user- accessible section 30 extending out from the housing 1 .
  • the button 3 comprises an inner wall 31 extending towards the proximal end of the housing 1 .
  • a recess/cut- out 32 is arranged in the inner wall 31 of the button, as shown in Fig. 13, and Figs 22-23.
  • the inner wall 31 of the button 3 blocks the first tab 102 from flexing radially outward.
  • the protrusion 102a is engaged with the ledge 72 of the housing 1 .
  • the recess/cut-out 32 is lined up with the protrusion 102a of the first tab 102.
  • the first tab 102 flexes into the recess/cut-out 32.
  • the protrusion 102a is disengaged from the edge 72 of the housing 1 , as shown in Figs 15-16.
  • the control sleeve 10 now is moved in the proximal direction relative to the housing 1 by the penetration spring 4.
  • the second tab 103 of the control sleeve 10 is configured to be releasably attached to the container driver 5, as shown in Fig. 14.
  • the inward protrusion 103b of the second tab 103 is configured to snap fit to a recess/cut-out 54 of the container driver 5.
  • the container driver 5 is moved to the proximal end of the housing 1 by the control sleeve 10 under the force of the penetration spring 4.
  • the proximal movement of the container driver 5 causes the container driver 5 to move from the first position to the second position when the button 3 is moved in the proximal direction relative to the housing 1 , e.g., the button is pressed by the user.
  • the housing 1 comprises a support wall 76.
  • the inner housing sleeve 7 comprises the support wall 76.
  • the support wall 76 is configured to engage with the outward protrusion 103a of the second tab 103 of the control sleeve 10.
  • the inward protrusion 103b can be retained in the recess/cut-out 54 of the container driver 5 during the container driver 5 is moved from the first position to the second position.
  • the length of the support wall 76 in the direction of the longitudinal axis L is configured to define the distance between the first position and the second position of the container driver 5.
  • the support wall 76 makes sure that an injection needle has reached a predetermined injection depth before the plunger rod 6 starts to expel medicament.
  • the support wall 76 no longer blocks the second tab 103 of the control sleeve from flexing radially outward.
  • the second tab 103 flexes radially outward, as shown in Fig. 17, thus, the inward protrusion is disengaged from the recess/cut-out 54 of the container driver 5.
  • the first tab 102 of the control sleeve 10 can be designed to pull the button 3 towards the proximal end of the housing 1 via the engagement between the protrusion 102a of the first tab 102 and the recess/cut-out 32 of the inner wall 31 of the button 3.
  • the inner wall 31 of the button 3 comprises a second recess/cut-out 33, as shown in Figs 22-23
  • the housing 1 comprises a bump 17.
  • the bump 17 is configured to loosely engage with the recess/cut-out 32 of the inner wall 31 of the button 3 to prevent the user from accidentally triggering the medicament delivery device, e.g., while the user is still observing the medicament delivery device.
  • the bump 17 is configured to lock the button 3 in a pressed position.
  • the second recess/cut-out 33 of the inner wall 31 of the button 3 can be either designed to be pressed to engage with the bump 17 or be pulled by the control sleeve 10 to engage with the bump 17.
  • the bump 17 can be designed as a loose lock to temporarily lock the button 3 in the pressed position during medicament delivery operation to provide an indication to the user.
  • the button 3 can be used with the above-mentioned design that is configured to use the button 3 to block the container driver 5 from being moved towards the distal end of the housing 1 when the button 3 is pressed by the user.
  • the bump 17 can be designed to completely block the button 3 from being moved in the distal direction relative to the housing 1 .
  • the container driver 5 comprises a second recess/cut-out 55 configured to be engaged with the inward protrusion 103b of the second tab 103 when the container driver 5 is moved in the distal direction relative to the housing 1 by the biasing member s, as shown in Fig. 18.
  • the medicament container M is held within the housing 1 after medicament delivery operation.
  • the housing of the medicament delivery device may be provided with (i.e., molded in, molded with) a compound featuring persistently antimicrobial, antifungal, and/or antiviral properties.
  • a compound featuring persistently antimicrobial, antifungal, and/or antiviral properties may be applied to the molded (i.e., finished) components through secondary processes (e.g., chemical vapor deposition), spraying, or dipping processes.
  • sub-assembly according to clause 1 , wherein the sub-assembly comprises a container carrier configured to accommodate the medicament container of the medicament delivery device. 3. The sub-assembly according to clause 2, wherein the container driver is engaged with the container carrier.
  • the biasing member is a spring extending between a first end and a second in the direction of the longitudinal axis; wherein the spring is engaged with the housing at the first end and engaged with the container driver at the second end.
  • the housing comprises an inner housing sleeve; wherein the container driver is positioned within the inner housing sleeve; and wherein the inner housing sleeve comprises the proximally directed surface of the housing.
  • the plunger rod is configured to be connected to a power source to move the plunger rod into the medicament container; wherein the plunger rod comprises a proximally directed surface releasably engaged with the distally directed surface of the container driver such that the plunger rod is prevented from being moved by the power source relative to the container driver until the plunger rod is disengaged from the distally directed surface of the container driver.
  • the housing comprises a wall facing towards the longitudinal axis; wherein the wall comprises a proximal section and a distal section closer to the longitudinal axis than the proximal section; and wherein an edge of the distal section adjacent to the proximal section comprises the proximally directed surface of the housing.
  • the sub-assembly comprises a button movably attached to the housing; wherein the button comprises a user- accessible section extending out from the housing and a proximally directed surface configured to be engaged with a second distally directed surface of the container driver.
  • the button comprises a proximally extending arm; wherein the container driver comprises a protrusion extending in the direction transverse to the longitudinal axis; and wherein the arm of the button is configured to snap over the protrusion of the container driver when the container driver moves from the first position to the second position such that a tactile/aud ible indication is generated.
  • the housing comprises a flexible section comprising a protrusion extending towards the longitudinal axis; wherein the protrusion is configured to be operably engaged with the medicament container; wherein the sub-assembly comprises a cap removably attached to the proximal end of the housing; and wherein the cap comprises a wall adjacent to the flexible section of the housing when the cap is attached to the housing. 19.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Un boîtier s'étend le long d'un axe longitudinal entre une extrémité proximale et une extrémité distale ; le boîtier comprenant une surface dirigée de manière proximale ; une tige de piston logée avec le boîtier ; la tige de piston comprenant un corps conçu pour être déplacé dans un récipient de médicament du dispositif d'administration de médicament; un dispositif d'entraînement de récipient conçu pour venir en prise fonctionnelle avec le récipient de médicament de telle sorte que le récipient de médicament est immobile par rapport à l'entraînement de récipient dans la direction de l'axe longitudinal ; le dispositif d'entraînement de récipient comprenant une section flexible comprenant une surface dirigée de manière distale ; le dispositif d'entraînement de récipient étant positionné entre la tige de piston et le boîtier dans une direction transversale à l'axe longitudinal ; un élément de sollicitation conçu pour être relié de manière fonctionnelle au récipient de médicament pour solliciter le récipient de médicament vers l'extrémité distale du boîtier ; la tige de piston étant mobile le long de l'axe longitudinal entre une position distale dans laquelle la section flexible du dispositif d'entraînement de récipient est déviée radialement par le corps de la tige de piston et une position proximale dans laquelle le corps de la tige de piston est dégagé de la section flexible du dispositif d'entraînement de récipient.
PCT/EP2024/088220 2024-01-08 2024-12-20 Sous-ensemble d'un dispositif d'administration de médicament Pending WO2025149370A1 (fr)

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EP24150615.3 2024-01-08

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1715903B1 (fr) * 2004-01-23 2007-10-24 The Medical House Plc Dispositif d'injection
WO2007129324A2 (fr) * 2006-05-09 2007-11-15 Gil Yigal dispositif d'injection jetable avec mÉcanisme d'auto-rÉtraction
US20100094214A1 (en) * 2006-09-06 2010-04-15 Becton Dickinson France S.A.S. Automatic Injection Device With Temporizing Means
US20210290847A1 (en) * 2020-03-20 2021-09-23 Alexander Nikon Auto-injector
US20220211945A1 (en) * 2019-03-15 2022-07-07 Eli Lilly And Company Medication injection system
US20230076297A1 (en) * 2020-02-14 2023-03-09 TAISEl KAKO GO., LTD. Injection device
US20230241319A1 (en) * 2006-01-23 2023-08-03 Shl Medical Ag Injection device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1715903B1 (fr) * 2004-01-23 2007-10-24 The Medical House Plc Dispositif d'injection
US20230241319A1 (en) * 2006-01-23 2023-08-03 Shl Medical Ag Injection device
WO2007129324A2 (fr) * 2006-05-09 2007-11-15 Gil Yigal dispositif d'injection jetable avec mÉcanisme d'auto-rÉtraction
US20100094214A1 (en) * 2006-09-06 2010-04-15 Becton Dickinson France S.A.S. Automatic Injection Device With Temporizing Means
US20220211945A1 (en) * 2019-03-15 2022-07-07 Eli Lilly And Company Medication injection system
US20230076297A1 (en) * 2020-02-14 2023-03-09 TAISEl KAKO GO., LTD. Injection device
US20210290847A1 (en) * 2020-03-20 2021-09-23 Alexander Nikon Auto-injector

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