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WO2025148231A1 - Composition de médecine chinoise traditionnelle externe pour le traitement de l'hyperémèse gravidique - Google Patents

Composition de médecine chinoise traditionnelle externe pour le traitement de l'hyperémèse gravidique

Info

Publication number
WO2025148231A1
WO2025148231A1 PCT/CN2024/097965 CN2024097965W WO2025148231A1 WO 2025148231 A1 WO2025148231 A1 WO 2025148231A1 CN 2024097965 W CN2024097965 W CN 2024097965W WO 2025148231 A1 WO2025148231 A1 WO 2025148231A1
Authority
WO
WIPO (PCT)
Prior art keywords
chinese medicine
external
traditional chinese
medicine composition
hyperemesis gravidarum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2024/097965
Other languages
English (en)
Chinese (zh)
Inventor
张勤华
林益
刘丹
翁晓晨
马娟娟
章晓乐
胡攀伟
李丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shuguang Hospital Affiliated to Shanghai University of TCM
Original Assignee
Shuguang Hospital Affiliated to Shanghai University of TCM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shuguang Hospital Affiliated to Shanghai University of TCM filed Critical Shuguang Hospital Affiliated to Shanghai University of TCM
Publication of WO2025148231A1 publication Critical patent/WO2025148231A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Definitions

  • the invention relates to the field of traditional Chinese medicine, in particular to an external Chinese medicine composition for treating hyperemesis gravidarum.
  • HG Hyperemesis Gravidarum
  • intravenous fluid support is mainly used in clinical practice to correct dehydration, ketoacidosis and electrolyte imbalance, and antiemetics are used as appropriate to prevent and treat complications.
  • factors such as long hospitalization time and increased economic burden, pregnant patients are not very accepting of this treatment.
  • the first aspect of the present invention provides a Chinese medicine composition for external use for treating hyperemesis gravidarum, which is composed of the following raw materials: 250-300g of ginger and pinellia, 250-300g of tangerine peel, 250-300g of cloves, 250-300g of Shenqu, and 300-400ml of ginger juice.
  • the external Chinese medicine composition is composed of the following raw materials: 300g of ginger and pinellia, 300g of tangerine peel, 300g of cloves, 300g of Shenqu, and 350ml of ginger juice.
  • the second aspect of the present invention provides a pharmaceutical preparation comprising the above-mentioned external Chinese medicine composition as an active ingredient.
  • the drug preparation is a Chinese medicine acupoint application.
  • the third aspect of the present invention provides a use of the above-mentioned external Chinese medicine composition in the preparation of a medicament for treating hyperemesis gravidarum.
  • a fourth aspect of the present invention provides a use of the pharmaceutical preparation as described above in the preparation of a drug for treating hyperemesis gravidarum.
  • ginger and pinellia are used as the main medicine, which is pungent in taste, warm in nature, and enters the spleen meridian, stomach meridian, and lung meridian, and has the effect of reducing adverse reactions and stopping vomiting.
  • Clove is used as the assistant medicine, which is pungent and warm in nature, and enters the spleen, stomach, and kidney meridians. It has the effects of warming the middle, warming the kidney, and reducing adverse reactions, and is mainly used to treat diseases such as hiccups, vomiting, and nausea. The two medicines are used together.
  • Shenqu and tangerine peel are used as adjuvants. Shenqu tastes sweet, pungent, and warm, and enters the spleen and stomach meridians. Tangerine peel is bitter, pungent, and warm in nature, and enters the lung and spleen meridians.
  • the two medicines complement each other and have the effects of strengthening the spleen and stomach, and regulating digestion. It treats diseases such as food stagnation, chest distension, abdominal distension, vomiting, and hiccups.
  • ginger juice is used as the assistant medicine, which is pungent in taste and slightly warm in nature.
  • the experimental methods in the following examples without specific conditions are usually carried out under conventional conditions or according to the conditions recommended by the manufacturer.
  • the medicinal materials obtained are all Chinese medicinal pieces unless otherwise specified.
  • the medicinal pieces can be obtained from the sales company or processed after being obtained.
  • Embodiment 1 the composition of Chinese medicine composition of the present invention
  • Embodiment 2 Composition of the Chinese medicine composition of the present invention
  • 260g ginger and pinellia 260g tangerine peel, 260g cloves, 260g Shenqu, 320ml ginger juice.
  • Embodiment 3 the composition of the Chinese medicine composition of the present invention
  • Embodiment 4 the composition of Chinese medicine composition of the present invention
  • Embodiment 5 Composition of the Chinese medicine composition of the present invention
  • the raw materials are weighed and made into coin-sized pills, which are attached to the middle of the external application patch. When used, they are attached to the patient's Neiguan acupoint and Zusanli (bilaterally), and are changed once a day for 14 days.
  • the screened patients with hyperemesis gravidarum were randomly divided into a Chinese medicine group and a control group according to the order of admission, with 50 cases in each group.
  • Control group about 3000mL of intravenous fluid infusion.
  • Commonly used drugs 5% glucose injection, 5% glucose sodium chloride injection, 10% glucose injection, medium/long chain fat emulsion injection; vitamin B6, vitamin B1, vitamin C, and potassium chloride are supplemented at the same time.
  • Patients with obvious vomiting should be given balanced fluid intravenous drip; patients with metabolic acidosis should be given 5% sodium bicarbonate solution intravenous drip as appropriate; patients with severe dehydration and decreased urine volume should increase the amount of fluid infusion appropriately, and the amount of fluid infusion should be adjusted according to the severity of the patient's dehydration. Continuous infusion for at least 3 days.
  • Chinese medicine acupoint application was used on the basis of nutritional support treatment of the control group.
  • the preparation method of acupoint application is as follows: 300g of ginger and pinellia, 300g of tangerine peel, 300g of cloves, 300g of Shenqu, 350ml of ginger juice Make a coin-sized pill and stick it in the middle of the external dressing, and stick it on the patient's Neiguan acupoint and Zusanli acupoint (on both sides). Change it once a day for 14 days.
  • Criteria for judging efficacy Cured: symptoms of nausea and vomiting disappear, the patient can eat normally, weight no longer decreases, urine ketone bodies in urine analysis turn negative, and various biochemical indices and electrolytes return to normal; Effective: symptoms of nausea and vomiting are alleviated, stomach discomfort improves, the patient can eat normally, weight no longer decreases, urine ketone bodies in urine analysis decrease, and various biochemical indices basically return to normal; Ineffective: symptoms of vomiting are not improved or worsen, urine ketone bodies in urine analysis remain positive, and various biochemical indices have not recovered or have worsened.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une composition de médecine chinoise traditionnelle externe pour le traitement de l'hyperémèse gravidique, comprenant les ingrédients pharmaceutiques actifs suivants : 250 à 300 g de pinellia traité au gingembre, 250 à 300 g d'écorce de tangerine séchée, 250 à 300 g de clou de girofle, 250 à 300 g de levain médicamenteux et 300 à 400 ml de jus de gingembre. La composition de médecine chinoise traditionnelle externe est utilisée pour préparer une application de point d'acupuncture de médecine chinoise traditionnelle pour traiter l'hyperémèse gravidique. Le procédé thérapeutique utilisant l'application de médecine chinoise traditionnelle externe est sûr pour le corps maternel et le fœtus et a peu de toxicité de reproduction. Une thérapie externe est utilisée pour mettre en œuvre la rate et suscite l'appétit, ce qui peut favoriser une augmentation de l'appétit d'un patient souffrant d'l'hyperémèse gravidique. Au moyen de l'application de point d'acupuncture, la composition de médecine chinoise traditionnelle agit sur un point d'acupuncture Neiguan (le méridien du Péricarde, Jueyin de main) et un point d'acupuncture Zusanli (le méridien de l'Estomac, Yangming du pied), calant ainsi l'énergie à augmentation indésirable, régulant nausées et vomissements et diminuant la fréquence des vomissements. La thérapie d'application externe de médecine chinoise traditionnelle, avec une thérapie de support de fluide intraveineux, peut soulager significativement les symptômes de vomissements et raccourcir la longueur de séjour et le temps de thérapie.
PCT/CN2024/097965 2024-01-10 2024-06-07 Composition de médecine chinoise traditionnelle externe pour le traitement de l'hyperémèse gravidique Pending WO2025148231A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202410034565.5A CN117959404A (zh) 2024-01-10 2024-01-10 一种治疗妊娠剧吐的外用中药组合物
CN202410034565.5 2024-01-10

Publications (1)

Publication Number Publication Date
WO2025148231A1 true WO2025148231A1 (fr) 2025-07-17

Family

ID=90862542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2024/097965 Pending WO2025148231A1 (fr) 2024-01-10 2024-06-07 Composition de médecine chinoise traditionnelle externe pour le traitement de l'hyperémèse gravidique

Country Status (2)

Country Link
CN (1) CN117959404A (fr)
WO (1) WO2025148231A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117959404A (zh) * 2024-01-10 2024-05-03 上海中医药大学附属曙光医院 一种治疗妊娠剧吐的外用中药组合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030008446A (ko) * 2001-07-18 2003-01-29 정영내 생강을 주성분으로 하는 입덧완화 조성물
CN106492172A (zh) * 2016-11-30 2017-03-15 宜都市妇幼保健院 一种中药帖剂及其制备方法和应用
CN107753921A (zh) * 2017-12-15 2018-03-06 河南中医药大学 一种治疗妊娠剧吐的中药贴脐剂
CN117959404A (zh) * 2024-01-10 2024-05-03 上海中医药大学附属曙光医院 一种治疗妊娠剧吐的外用中药组合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030008446A (ko) * 2001-07-18 2003-01-29 정영내 생강을 주성분으로 하는 입덧완화 조성물
CN106492172A (zh) * 2016-11-30 2017-03-15 宜都市妇幼保健院 一种中药帖剂及其制备方法和应用
CN107753921A (zh) * 2017-12-15 2018-03-06 河南中医药大学 一种治疗妊娠剧吐的中药贴脐剂
CN117959404A (zh) * 2024-01-10 2024-05-03 上海中医药大学附属曙光医院 一种治疗妊娠剧吐的外用中药组合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Herbal Pairings for Surgical Diseases in Clinical Practice", 31 January 2014, PEOPLE'S MILITARY MEDICAL PUBLISHING HOUSE, CN, ISBN: 9787509170526, article ZHOU, XINGLAI: " 3. Tangerine Peel and Medicated Leaven", pages: 70 - 72, XP009564089 *
LIU QIUJIN, FU JINYING: "Collection of Professor Fu Jinying's Clinical Experience in Treating Hyperemesis Gravidarum via Disease-Syndrome Integration", CHINESE JOURNAL OF ETHNOMEDICINE AND ETHNOPHARMACY, vol. 27, no. 13, 31 July 2018 (2018-07-31), pages 46 - 48, XP093335880, ISSN: 1007-8517 *

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