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WO2025146394A1 - Dispositif d'administration de médicament et ensemble d'administration de médicament - Google Patents

Dispositif d'administration de médicament et ensemble d'administration de médicament Download PDF

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Publication number
WO2025146394A1
WO2025146394A1 PCT/EP2024/088169 EP2024088169W WO2025146394A1 WO 2025146394 A1 WO2025146394 A1 WO 2025146394A1 EP 2024088169 W EP2024088169 W EP 2024088169W WO 2025146394 A1 WO2025146394 A1 WO 2025146394A1
Authority
WO
WIPO (PCT)
Prior art keywords
medicament delivery
medicament
delivery device
container
assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/088169
Other languages
English (en)
Inventor
Daniel Carlsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHL Medical AG
Original Assignee
SHL Medical AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHL Medical AG filed Critical SHL Medical AG
Publication of WO2025146394A1 publication Critical patent/WO2025146394A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/2474—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with movable piercing means, e.g. ampoule remains fixed or steady
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2477—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means to reduce play of ampoule within ampoule holder, e.g. springs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2481—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for biasing the ampoule out of the ampoule holder

Definitions

  • the invention is in the field of medicament delivery devices.
  • it relates to automatic medicament delivery devices.
  • It relates especially to medicament delivery devices comprising an attachable needle assembly.
  • the invention can more particularly relate to medicament delivery devices for delivering at least one dose which is different from the full contents of a medicament container assembled with the medicament delivery device, especially to medicament delivery devices for delivering multiple doses of a medicament from one medicament container.
  • Such medicament delivery devices and medicament delivery assemblies should generally be safe to use and easy to handle, and they should ensure delivery of the designated dose of the medicament with high accuracy.
  • One way of lowering the carbon footprint here is to reduce the amount of material involved, in particular plastics. This can be accomplished by enabling the medicament delivery device to deliver multiple doses instead of only a single one.
  • the dosing amount expelled usually is controlled by controlling the plunger stroke, i.e., by controlling the length of the axial (usually proximal) movement of the plunger rod device (or plunger rod), expecting that this corresponds to the length of the movement of the stopper device (or plunger). Therefore, for a plunger rod's stroke to accurately correlate to a dosing volume, the plunger rod needs to be in contact with the plunger during the whole stroke, also at the very beginning of the plunger rod movement.
  • This initial step is to ensure contact between plunger rod and stopper. Sometimes it also ensures that any air inside the primary container is removed from the container before the first injection, i.e., before the delivery of the first dose.
  • one object of the invention is to create a new medicament delivery device for delivering one or more doses, in particular preset (pre-determined) doses, of a medicament from a medicament container with high accuracy.
  • Another object of the invention is to create a medicament delivery device for delivering multiple preset doses of a medicament from a medicament container with high accuracy.
  • the medicament delivery device should be advantageous in terms of safety and reliability.
  • the medicament delivery device is a medicament delivery device for accommodating a medicament container comprising a container body containing a medicament and for expelling one or more doses, in particular multiple doses, of the medicament from the medicament container.
  • the medicament delivery device defines a device axis and comprises a needle assembly comprising a needle device, such as a needle embodied as a cannula, and a first assembly member; and an attaching mechanism for attaching the needle assembly to a first part of the medicament delivery device in an attachment process in which the needle device moves distally and the first assembly member carries out a first movement, in particular wherein the first movement comprises a distal movement.
  • the medicament delivery device comprises a priming mechanism configured to effect a conversion process in which a distal movement of the container body is derived from the first movement of the first assembly member.
  • the distal movement of the container body in particular can be a distal movement relative to the first part.
  • the conversion process at least a part (or component) of the first movement of the first assembly member is converted into a distal movement of the container body.
  • the priming mechanism can effect a priming process, in particular a priming process taking place during the attachment process.
  • the needle device can move distally relative to the first part.
  • the needle device pierces a seal of the medicament container, such as a septum, in particular wherein this piercing takes place, in the priming process, before said distal movement of the container body is derived from said first movement.
  • a seal of the medicament container such as a septum
  • the needle device and the container body both move distally, more particularly the container body moving at least as fast distally as the needle device.
  • the medicament container comprises a stopper device
  • the medicament delivery device comprises a plunger rod device comprising an abutting part; wherein the priming mechanism is configured to decrease an axial distance between the stopper device and the abutting part of the plunger rod device.
  • the abutting part can in particular be configured for abutting and proximally moving the stopper device during expelling the one or more doses.
  • the decreasing said axial distance can in particular take place during the attachment process and/or by the conversion process.
  • the priming mechanism is configured to effect an abutting of the abutting part and the stopper device against one another. This can eliminate uncertainty in expelled dose volume related to an initial distance between abutting part and the stopper device.
  • Said abutting can in particular take place during the attachment process and/or by the conversion process.
  • the priming mechanism is configured to effect a proximal movement of the stopper device forced by the plunger rod device (due to the distal movement of the container body). This way, air can be expelled from the medicament container (if present therein) and/or a portion of the medicament can be expelled from the medicament container. This further increases dosing accuracy.
  • the first part and the plunger rod device (more particularly the abutting part) have a constant axial distance to one another. Their relative axial position can be locked. E.g., both can have a fixed axial position relative to a housing part of the medicament delivery device.
  • the medicament delivery device comprises a biasing device configured to force the plunger rod device in a proximal direction.
  • the biasing device can comprise a spring device.
  • the medicament delivery device comprises a release mechanism for selectively releasing the biasing device.
  • the biasing device forces the plunger rod device proximally, and when not released, the biasing device does not force the plunger rod device proximally, e.g., the biasing device can be blocked.
  • the medicament delivery device can furthermore be configured such that during the attachment process the biasing device is not released.
  • the attaching mechanism comprises a bayonet connection between the needle assembly and the first part.
  • the first assembly member can comprise a protrusion such as a pin, cooperating with a suitable slit present in the first part.
  • the attaching mechanism comprises a ratch-type connection between the needle assembly and the first part.
  • the needle assembly comprising an inner ratch cooperating with an outer ratch of the first part (or vice versa).
  • the attaching mechanism comprises a snap-fit connection between the needle assembly and the first part.
  • the first assembly member can comprise a protrusion on a lever cooperating with an opening present in the first part (or vice versa). By engaging the snap fit connection, a distal movement of the first assembly member can take place.
  • the first movement comprises a distal movement, in particular wherein in the conversion process, the distal movement of the container body can be derived from the distal movement of the first assembly member.
  • the distal movement of the first assembly member can be converted into a distal movement of the container body. This can be accomplished, e.g., in a simple process, directly converting the one distal movement into the other distal movement.
  • the priming mechanism comprises a spacer device configured to abut, in the conversion process, both, the first assembly member and the container body.
  • the spacer device is arranged between the first assembly member and the container body.
  • the spacer device e.g., can be clamped between the first assembly member and the container body during the conversion process.
  • the spacer device can be distally moved by the first arrangement member and can, itself, distally move the contained body.
  • the spacer device abuts the first assembly member at one side, in particular proximally, and abuts the container body at another side, e.g., distally.
  • the first movement comprises a rotational movement, in particular wherein in the conversion process, the distal movement of the container body can be derived from the rotational movement of the first assembly member.
  • the rotational movement of the first assembly member can be converted into a distal movement of the container body.
  • the priming mechanism comprises one or more threaded parts cooperating with the needle assembly, more particularly cooperating with a rotatable part of the needle assembly (rotating during the attachment process).
  • the threaded parts convert the rotational movement into a distal movement which can be converted into a distal movement of the container body by the threaded parts abutting the container body.
  • the first part comprises a container compartment member configured to accommodate the medicament container. More particularly, the distal movement of the medicament container can be a distal movement of the medicament container relative to the container compartment member. During the conversion process, the medicament container can move distally relative to the container compartment member.
  • priming is accomplished by proximally moving the plunger rod (or plunger rod device), more particularly by proximally moving the plunger rod (or plunger rod device) relative to a container compartment member. And the container body either is unmoved relative to the container compartment member or (initially) moves proximally relative to the container compartment member.
  • the medicament container comprises a seal, e.g., a septum, and the medicament delivery device is configured to ensure that during the attachment process, the needle device pierces the seal prior to the priming mechanism deriving the distal movement of the container body.
  • a seal e.g., a septum
  • the medicament delivery device comprises a dosing device for controlling a dosing amount for each of the one or more doses.
  • the dosing device can control the plunger rod stroke taking place for delivery of a dose, i.e., can control the distal movement carried out by the plunger rod device when a dose is expelled, by initially releasing and, at the end, blocking the biasing device.
  • the dosing device can, e.g., comprise the release mechanism mentioned above.
  • the medicament delivery assembly comprises the medicament delivery device as herein described and further comprises the medicament container assembled with the medicament delivery device.
  • distal direction refers to the direction pointing away from the dose delivery site during use of the medicament delivery device.
  • distal part/end refers to the part/end of the delivery device, or the parts/ends of the members thereof, which during use of the medicament delivery device is/are located furthest away from the dose delivery site.
  • proximal direction refers to the direction pointing towards the dose delivery site during use of the medicament delivery device.
  • proximal part/end this refers to the part/end of the delivery device, or the parts/ends of the members thereof, which during use of the medicament delivery device is/are located closest to the dose delivery site.
  • longitudinal refers to a direction extending from the proximal end to the distal end and along the device or components thereof, typically in the direction of the longest extension of the device and/or component.
  • transverse refers to a direction generally perpendicular to the longitudinal direction.
  • Figure 2B the proximal portion of the medicament delivery device assembly of Fig. 2A, in a view onto a cross-section;
  • Figure 7A, 7B the spacer device of the medicament delivery device of Figs. 2A, 2B, in two different perspective views;
  • medicament container 3 is accommodated in container compartment member 16 and it extends, in particular its container body 3d extends, at its distal end, slightly beyond compartment member 16.
  • Plunger rod device 6 is slightly distant from stopper device 3b.
  • Contact member 183 of spacer device 181 extend far through openings 150 in container compartment member 16, extending out of container compartment member 16, while ring member 182 is located inside container compartment member 16, e.g., abutting container body 3d with its abutting surface 18b.
  • spacer device 181 with its contact members 183 extending through respective openings 150 in container compartment member 16, is distally moved and can distally move medicament container 3, in particular container body 3d, while abutting container body 3d with abutting surface 15a.
  • container body 3d can be distally moved, until stopper devicesb (initially moving together with container body 6) abuts plunger rod device 6 (more particularly abutting part 62), and possibly even until a small portion of the medicament is expelled through needle 5a.
  • container body 3d is distally moved in reaction to the attachment process depends on the initial axial distance between plunger rod device 6 (more particularly abutting part 62) and stopper 3b and on the design of spacer device 181 and on its initial distance to container compartment member 16 (which can be zero, in which case spacer device 181 initially abuts container compartment member 16), and it depends on how far assembly member 51 (more particularly its abutting surface 15a) can distally move spacer device 181 which is, in the illustrated embodiment, limited by assembly member 51 abutting container compartment member 16 at the end of the attachment process.
  • Other stops in particular mechanical stops for limiting the distal movement of assembly member 51 during the attachment process are possible. This depends, too, on the type of attachment mechanism, as not only screw couplings are possible, but also others, such as bayonet connections, ratch-type connections, snap-fit connections.
  • needle 5a pierces seal 3a.
  • medicament container 3 in particular its container body 3d, extends at its distal end, a bit further beyond compartment member 16 than in the pre-assembled state
  • attaching mechanism 15 in the illustrated embodiment comprises thread 155 of assembly member 51 and thread 156 of container compartment member 16.
  • priming mechanism 18 comprises spacer device 181.
  • a rotational movement of a first assembly member could be converted into a distal movement of container body 3d, e.g., using another threaded item.
  • the delivery devices described herein can be used for the treatment and/or prophylaxis of one or more of many different types of disorders.
  • Exemplary disorders include, but are not limited to: rheumatoid arthritis, inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis), hypercholesterolaemia and/or dyslipidemia, cardiovascular disease, diabetes (e.g.
  • psoriasis psoriatic arthritis
  • spondyloarthritis hidradenitis suppurativa
  • Sjogren's syndrome migraine, cluster headache, multiple sclerosis, neuromyelitis optica spectrum disorder, anaemia, thalassemia, paroxysmal nocturnal hemoglobinuria, hemolytic anaemia, hereditary angioedema, systemic lupus erythematosus, lupus nephritis, myasthenia gravis, Behget's disease, hemophagocytic lymphohistiocytosis, atopic dermatitis, retinal diseases (e.g., age-related macular degeneration, diabetic macular edema), uveitis, infectious diseases, bone diseases (e.g., osteoporosis, osteopenia), asthma, chronic obstructive pulmonary disease, thyroid eye disease, nasal polyps, transplant, acute hypoglyca
  • Exemplary types of drugs that could be included in the delivery devices described herein include, but are not limited to, small molecules, hormones, cytokines, blood products, enzymes, vaccines, anticoagulants, immunosuppressants, antibodies, antibody-drug conjugates, neutralizing antibodies, reversal agents, radioligand therapies, radioisotopes and/or nuclear medicines, diagnostic agents, bispecific antibodies, proteins, fusion proteins, peptibodies, polypeptides, pegylated proteins, protein fragments, nucleotides, protein analogues, protein variants, protein precursors, protein derivatives, chimeric antigen receptor T cell therapies, cell or gene therapies, oncolytic viruses, or immunotherapies.
  • Exemplary drugs that could be included in the delivery devices described herein include, but are not limited to, immuno-oncology or bio-oncology medications such as immune checkpoints, cytokines, chemokines, clusters of differentiation, interleukins, integrins, growth factors, coagulation factors, enzymes, enzyme inhibitors, retinoids, steroids, signaling proteins, pro- apoptotic proteins, anti-apoptotic proteins, T-cell receptors, B-cell receptors, or costimulatory proteins.
  • immuno-oncology or bio-oncology medications such as immune checkpoints, cytokines, chemokines, clusters of differentiation, interleukins, integrins, growth factors, coagulation factors, enzymes, enzyme inhibitors, retinoids, steroids, signaling proteins, pro- apoptotic proteins, anti-apoptotic proteins, T-cell receptors, B-cell receptors, or costimulatory proteins.
  • Exemplary drugs that could be included in the delivery devices described herein include, but are not limited to, those exhibiting a proposed mechanism of action, such as human epidermal growth factor receptor 2 (HER-2) receptor modulators, interleukin (IL) modulators, interferon (IFN) modulators, complement modulators, glucagon-like peptide-i (GLP-i) modulators, glucose-dependent insulinotropic polypeptide (GIP) modulators, cluster of differentiation 38 (CD38) modulators, cluster of differentiation 22 (CD22) modulators, Ci esterase modulators, bradykinin modulators, C-C chemokine receptor type 4 (CCR4) modulators, vascular endothelial growth factor (VEGF) modulators, B-cell activating factor (BAFF), P-selectin modulators, neonatal Fc receptor (FcRn) modulators, calcitonin gene-related peptide (CGRP) modulators, epidermal growth factor receptor (EGFR) modulators, cluster of differentiation 79B (CD79B
  • Exemplary drugs that could be included in the delivery devices described herein include, but are not limited to: etanercept, abatacept, adalimumab, evolocumab, exenatide, secukinumab, erenumab, galcanezumab, fremanezumab-vfrm, alirocumab, methotrexate (amethopterin), tocilizumab, interferon beta-ia, interferon beta-ib, peginterferon beta-ia, sumatriptan, darbepoetin alfa, belimumab, sarilumab, semaglutide, dupilumab, reslizumab, omalizumab, glucagon, epinephrine, naloxone, insulin, amylin, vedolizumab, eculizumab, ravulizumab, crizanlizuma
  • Exemplary drugs that could be included in the delivery devices described herein may also include, but are not limited to, oncology treatments such as ipilimumab, nivolumab, pembrolizumab, atezolizumab, durvalumab, avelumab, cemiplimab, rituximab, trastuzumab, ado-trastuzumab emtansine, fam-trastuzumab deruxtecan-nxki, pertuzumab, transtuzumab-pertuzumab, alemtuzumab, belantamab mafodotin-blmf, bevacizumab, blinatumomab, brentuximab vedotin, cetuximab, daratumumab, elotuzumab, gemtuzumab ozogamicin, 90-Yttrium-ibritumo
  • Exemplary drugs that could be included in the delivery devices described herein also include, but are not limited to, those used for adjuvant or neoadjuvant chemotherapy, such as an alkylating agent, plant alkaloid, antitumor antibiotic, antimetabolite, or topoisomerase inhibitor, enzyme, retinoid, or corticosteroid.
  • adjuvant or neoadjuvant chemotherapy such as an alkylating agent, plant alkaloid, antitumor antibiotic, antimetabolite, or topoisomerase inhibitor, enzyme, retinoid, or corticosteroid.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Le dispositif d'administration de médicament (2) pour recevoir un récipient de médicament (3) comprend un corps de récipient (3d) contenant un médicament et pour expulser une ou plusieurs doses du médicament à partir du récipient de médicament (3). Le dispositif d'administration de médicament (2) définit un axe de dispositif (A) et comprend - un ensemble aiguille (5) comprenant un dispositif d'aiguille (5a) et un premier élément d'assemblage (51) ; et - un mécanisme de fixation (15) pour fixer l'ensemble aiguille (5) à une première partie (16) du dispositif d'administration de médicament (2) dans un processus de fixation dans lequel le dispositif d'aiguille (5a) se déplace de manière distale et le premier élément d'assemblage (51) effectue un premier mouvement, le premier mouvement comprenant un mouvement distal, - un mécanisme d'amorçage (18) configuré pour effectuer un processus de conversion dans lequel un mouvement distal du corps de récipient (3d) est dérivé du premier mouvement du premier élément d'assemblage (51).
PCT/EP2024/088169 2024-01-03 2024-12-20 Dispositif d'administration de médicament et ensemble d'administration de médicament Pending WO2025146394A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP24150241 2024-01-03
EP24150241.8 2024-01-03

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WO2025146394A1 true WO2025146394A1 (fr) 2025-07-10

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110276008A1 (en) * 2008-12-23 2011-11-10 Sanofi-Aventis Deutschland Gmbh Needle assembly and medication delivery system
US20120283646A1 (en) * 2009-09-30 2012-11-08 Sanofi-Aventis Deutschland Gmbh Drug delivery system, drug delivery device, needle assembly and method for priming
US20200179607A1 (en) * 2017-05-02 2020-06-11 Eli Lilly And Company Injection device with priming arrangement

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110276008A1 (en) * 2008-12-23 2011-11-10 Sanofi-Aventis Deutschland Gmbh Needle assembly and medication delivery system
US20120283646A1 (en) * 2009-09-30 2012-11-08 Sanofi-Aventis Deutschland Gmbh Drug delivery system, drug delivery device, needle assembly and method for priming
US20200179607A1 (en) * 2017-05-02 2020-06-11 Eli Lilly And Company Injection device with priming arrangement

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