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WO2025145994A1 - Lentille intraoculaire réglable - Google Patents

Lentille intraoculaire réglable Download PDF

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Publication number
WO2025145994A1
WO2025145994A1 PCT/CN2024/143406 CN2024143406W WO2025145994A1 WO 2025145994 A1 WO2025145994 A1 WO 2025145994A1 CN 2024143406 W CN2024143406 W CN 2024143406W WO 2025145994 A1 WO2025145994 A1 WO 2025145994A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
intraocular lens
connecting arm
adjustable intraocular
hardness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2024/143406
Other languages
English (en)
Chinese (zh)
Inventor
陈方
刘洋
孔祥玖
姚阳屹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hainan Intellimicro Medical Technology Co Ltd
Original Assignee
Hainan Intellimicro Medical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hainan Intellimicro Medical Technology Co Ltd filed Critical Hainan Intellimicro Medical Technology Co Ltd
Publication of WO2025145994A1 publication Critical patent/WO2025145994A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus

Definitions

  • the present disclosure relates to the technical field of ophthalmic medical devices, and in particular to an adjustable artificial lens.
  • Cataract extraction combined with intraocular lens implantation is still the only effective means of treating cataracts at present and in the future.
  • implanting a traditional monofocal intraocular lens after cataract surgery can achieve good long-distance vision, since monofocal intraocular lenses do not have the ability to adjust the focus, patients generally suffer from hyperopia after surgery and need to rely on glasses to meet the needs of different close-up work.
  • the shape or optical path of the intraocular lens itself can be changed by adjusting the filling amount of the optical fluid medium in the capsule or changing the type of the optical fluid medium, thereby adjusting the diopter of the intraocular lens.
  • the provision of a sealing valve on the capsule can facilitate the injection of the optical fluid medium into the capsule and prevent the leakage of the optical fluid medium, thereby ensuring the reliability and safety of the intraocular lens.
  • the ring body is a hard silicone body, and the main body is a soft silicone body.
  • the hardness of the ring body is between 80A-90A on the Shore Scale, and the hardness of the main body is between 20A-40A on the Shore Scale.
  • the hardness of the body is less than or equal to the hardness of the capsule.
  • the number of the sealing valves is two, and the two sealing valves are symmetrically arranged about the central axis of the capsule.
  • a groove that is recessed inwardly toward the chamber is provided in the middle portion of the sac body, and the sealing valve is spaced apart from the groove.
  • the bottom of the groove is configured as an optical convex mirror.
  • the capsule includes a front capsule and a rear capsule, and the front capsule and the rear capsule are connected;
  • connection between the front connecting arm and the front capsule is located at half the thickness of the front capsule; the connection between the rear connecting arm and the rear capsule is located at half the thickness of the rear capsule.
  • FIG1 is a schematic structural diagram of a capsule according to an embodiment of the present disclosure.
  • FIG2 is an enlarged view of a sealing valve according to an embodiment of the present disclosure
  • FIG3 is a schematic diagram of a structure in which two sealing valves are provided according to an embodiment of the present disclosure
  • FIG4 is a schematic diagram of a structure in which an optical convex mirror is included on a capsule according to an embodiment of the present disclosure
  • FIG5 is a schematic structural diagram of the entire haptic on an intraocular lens according to an embodiment of the present disclosure
  • FIG7 is a schematic diagram of the structure of the front capsule and the rear capsule according to an embodiment of the present disclosure.
  • FIG8 is a cross-sectional view of an intraocular lens according to an embodiment of the present disclosure.
  • FIG. 9 is a schematic diagram of the structure of an intraocular lens in an eye according to an embodiment of the present disclosure.
  • Reference numerals 100. Artificial lens; 10. capsule; 101. chamber; 11. groove; 12. front capsule; 13. rear capsule; 14. equator; 15. optical convex mirror; 20. Sealing valve; 21. Ring body; 22. Main body; 30. loop body; 31. front connecting arm; 32. rear connecting arm; 33. free end; 40. Seam line.
  • the following describes an adjustable intraocular lens 100 according to an embodiment of the present disclosure with reference to Figures 1 to 9, which includes a capsule 10 and a sealing valve 20.
  • a chamber 101 is formed in the capsule 10.
  • the sealing valve 20 includes a ring body 21 and a body 22.
  • the ring body 21 is arranged on the capsule 10, and the body 22 is arranged in the ring body 21.
  • the hardness of the body 22 is less than the hardness of the ring body 21.
  • the adjustable intraocular lens 100 is mainly composed of a capsule 10 and a sealing valve 20.
  • a chamber 101 is formed in the capsule 10.
  • the chamber 101 can be filled with an optical fluid medium (such as silicone oil).
  • an optical fluid medium such as silicone oil
  • the shape or optical path of the intraocular lens 100 itself can be changed, thereby adjusting the diopter of the intraocular lens 100.
  • a sealing valve 20 is provided on the capsule 10.
  • the sealing valve 20 is annular. Since the hardness of the body 22 in the sealing valve 20 is less than the hardness of the ring body 21, it is convenient for the injection needle to be inserted into the body 22, so that the optical fluid medium can be filled into the capsule 10.
  • the sealing valve 20 can seal the optical fluid medium in the capsule 10, thereby preventing the leakage of the optical fluid medium, thereby ensuring the reliability and safety of the intraocular lens 100.
  • the ring body 21 is a hard silicone body
  • the main body 22 is a soft silicone body.
  • the main body 22 of the sealing valve 20 is set to a soft silicone body, which can facilitate the injection needle to penetrate the soft silicone body to inject the optical fluid medium. Since the soft silicone body will undergo elastic deformation, when the injection needle is withdrawn from the soft silicone body, the soft silicone body will close itself, thereby preventing the leakage of the optical fluid medium.
  • the soft silicone body is arranged in the ring body 21, and the ring body 21 is a hard silicone body.
  • the hard silicone body can support the sealing valve 20, thereby avoiding deformation of the sealing valve 20 on the capsule 10, and the organic combination of soft and hard silicone bodies can form a closed whole. Furthermore, the hard silicone body can exert a force on the soft silicone body, thereby improving the sealing performance of the sealing valve 20 to the optical fluid medium.
  • the hardness of the ring body 21 is between 80A and 90A on Shore A, and the hardness of the body 22 is between 20A and 40A on Shore A.
  • the hardness of the ring body 21 is between 80A and 90A on Shore A
  • the hardness of the body 22 is between 20A and 40A on Shore A, which can prevent the body 22 and the capsule 10 from being deformed.
  • the body 22 and the capsule 10 are preferably made of the same material for easy processing and manufacturing.
  • the two sealing valves 20 are symmetrically arranged about the central axis of the capsule 10.
  • the two sealing valves 20 one of which can be used for injection, and the other plays a role of compensation and balance in mechanics, and can also be used as a spare valve body.
  • the two sealing valves 20 can be set at different positions on the capsule 10, so that different injection paths can be formed, and injection can be performed in different directions, which is convenient for flexible operation.
  • the two sealing valves 20 are symmetrically arranged about the central axis of the capsule 10, so that the optical area on the upper surface of the capsule 10 can produce uniform deformation.
  • the intraocular lens 100 further includes a parylene layer (not shown in the figure), and the parylene layer (preferably parylene C, which can be formed by a vapor deposition process) is disposed on the outer surface of the sealing valve 20.
  • the parylene layer preferably parylene C, which can be formed by a vapor deposition process
  • the Young's modulus and hardness of the parylene layer are significantly higher than those of the sealing valve 20, and the parylene layer has good adhesion to the sealing valve 20, which is equivalent to forming a reinforcing baffle on the outside of the sealing valve 20.
  • the optical fluid medium such as silicone oil
  • the sealing valve 20 can generate outward pressure on the sealing valve 20, and the outward pressure can make the sealing valve 20 self-closed under the protection of the rigid parylene layer, so that it can play a role of sealing and leak-proofing for a long time.
  • the parylene layer covers the outer surface of the sealing valve 20, and the parylene layer also partially covers the outer surface of the body 22, thereby increasing the contact area between the parylene layer and the sealing valve 20 and avoiding stress concentration at the connection between the sealing valve 20 and the bladder body 10.
  • a groove 11 is provided in the middle of the capsule 10, which is inwardly recessed toward the chamber 101, and the sealing valve 20 is spaced apart from the groove 11.
  • the provision of the groove 11 in the middle of the front side of the capsule 10 can reduce the tissue contact between the artificial lens 100 and the front wall of the lens capsule, thereby avoiding the influence on the optical path; the provision of the groove 11 in the middle of the rear side of the capsule 10 can reduce the tissue contact between the artificial lens 100 and the rear wall of the lens capsule, and avoid the influence of foreign tissue hyperplasia.
  • the sealing valve 20 is spaced apart from the groove 11, which can further avoid stress concentration.
  • the bottom of the groove 11 is constructed as an optical convex mirror 15, which can help focus and can be set according to actual needs.
  • the optical convex mirror 15 is preferably a PMMA (polymethyl methacrylate) film layer, which has the characteristics of high transparency and low refractive index.
  • the hardness of the optical convex mirror 15 is between 80A and 90A on the Shore A scale, thereby preventing the PMMA film layer from deforming.
  • the capsule 10 includes an anterior capsule 12 and a posterior capsule 13, and the anterior capsule 12 and the posterior capsule 13 are connected.
  • the adjustable intraocular lens 100 also includes a haptic 30, and the haptic 30 includes a front connecting arm 31, a rear connecting arm 32 and a free end 33, the front connecting arm 31 is connected to the outer surface of the anterior capsule 12, the rear connecting arm 32 is connected to the outer surface of the posterior capsule 13, the ends of the front connecting arm 31 and the rear connecting arm 32 form the free end 33, and the front connecting arm 31 and the rear connecting arm 32 have an angle therebetween.
  • the loop 30 is arranged on the capsule 10, and the loop 30 is mainly composed of a front connecting arm 31, a rear connecting arm 32 and a free end 33; the front connecting arm 31 is connected to the outer surface of the front capsule 12, and the rear connecting arm 32 is connected to the outer surface of the rear capsule 13.
  • the loop 30 is Y-shaped as a whole, and the specific connection position can be verified by mechanical simulation analysis and experiments, and the best force position can be found as the connection position of the loop 30.
  • the structural design of the front connecting arm 31 and the rear connecting arm 32 with an angle can facilitate the force balance of the capsule 10 in refractive adjustment, and can also achieve controllable deformation, thereby increasing the accuracy and effectiveness of refractive adjustment.
  • the capsule 10 has an equator 14, and the connection between the front capsule 12 and the rear capsule 13 avoids the equator 14, that is, the area of the connection between the front capsule 12 and the rear capsule 13 is smaller than the area of the equator 14.
  • the capsule 10 is an asymmetric ellipsoid as a whole, and the latitude increases from the front to the back, and when it reaches the maximum value, it starts to decrease backwards.
  • the maximum value in the middle is the equator 14.
  • the connection between the front capsule 12 and the rear capsule 13 is set by avoiding the equator 14, so as to avoid deformation of the capsule 10.
  • the connection between the front connecting arm 31 and the front capsule 12 is located at half the thickness of the front capsule 12, and the connection between the rear connecting arm 32 and the rear capsule 13 is located at half the thickness of the rear capsule 13.
  • the front connecting arm 31 is arranged at half the thickness of the front capsule 12, and the rear connecting arm 32 is arranged at half the thickness of the rear capsule 13.
  • the front connecting arm 31 and the rear connecting arm 32 are arranged symmetrically, so that the capsule 10 can be subjected to more balanced force during refractive adjustment, which is also convenient for actual operation, thereby improving the reliability of the intraocular lens 100.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une lentille intraoculaire réglable comprenant un corps de capsule avec une cavité formée à l'intérieur de celui-ci et une valve d'étanchéité comprenant un corps annulaire et un corps principal. Le corps annulaire est disposé sur le corps de capsule, le corps principal est disposé dans le corps annulaire, et la dureté du corps principal est inférieure à celle du corps annulaire.
PCT/CN2024/143406 2024-01-03 2024-12-27 Lentille intraoculaire réglable Pending WO2025145994A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202410008741.8A CN117860431A (zh) 2024-01-03 2024-01-03 可调节人工晶状体
CN202410008741.8 2024-01-03

Publications (1)

Publication Number Publication Date
WO2025145994A1 true WO2025145994A1 (fr) 2025-07-10

Family

ID=90594184

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2024/143406 Pending WO2025145994A1 (fr) 2024-01-03 2024-12-27 Lentille intraoculaire réglable

Country Status (2)

Country Link
CN (1) CN117860431A (fr)
WO (1) WO2025145994A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4608330A1 (fr) * 2023-10-23 2025-09-03 California Institute of Technology Lentille intraoculaire de réception de liquide dotée d'une chambre asymétrique
CN117860432A (zh) * 2024-01-03 2024-04-12 微智医疗器械有限公司 人工晶状体
CN117860431A (zh) * 2024-01-03 2024-04-12 微智医疗器械有限公司 可调节人工晶状体

Citations (10)

* Cited by examiner, † Cited by third party
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US20030018384A1 (en) * 2001-07-17 2003-01-23 Medennium, Inc. Accommodative intraocular lens
CN104039277A (zh) * 2011-11-16 2014-09-10 阿波罗内窥镜外科手术有限责任公司 与接入口一起使用的预装隔垫
CN104720932A (zh) * 2015-03-10 2015-06-24 北京艾克伦医疗科技有限公司 一种人工晶状体囊体及包括其的注射式人工晶状体
CN105377189A (zh) * 2013-11-14 2016-03-02 加州理工学院 调节性眼内晶体
CN107106293A (zh) * 2014-08-26 2017-08-29 施菲姆德控股有限责任公司 调节性人工晶状体
CN112135582A (zh) * 2017-12-07 2020-12-25 理查德·F·霍尼斯鲍姆 收缩包裹锚定的和收缩包裹致动的可调节人工晶状体及其植入方法
CN117860431A (zh) * 2024-01-03 2024-04-12 微智医疗器械有限公司 可调节人工晶状体
CN117860432A (zh) * 2024-01-03 2024-04-12 微智医疗器械有限公司 人工晶状体
CN117898858A (zh) * 2024-01-03 2024-04-19 微智医疗器械有限公司 人工晶状体
CN118593189A (zh) * 2023-10-23 2024-09-06 加州理工学院 具有非对称腔室的液体可调节人工晶状体

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US4636213A (en) * 1985-01-24 1987-01-13 Pakiam Anthony I Implantable prosthesis
US9186243B2 (en) * 2011-05-31 2015-11-17 Novartis Ag Accommodative intraocular lens and method of implantation
US9700405B2 (en) * 2014-03-31 2017-07-11 Mentor Worldwide Llc Directional tissue expander
WO2016109394A1 (fr) * 2014-12-29 2016-07-07 1Co, Inc. Structure de valve flexible pour réservoir implantable

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030018384A1 (en) * 2001-07-17 2003-01-23 Medennium, Inc. Accommodative intraocular lens
CN104039277A (zh) * 2011-11-16 2014-09-10 阿波罗内窥镜外科手术有限责任公司 与接入口一起使用的预装隔垫
CN105377189A (zh) * 2013-11-14 2016-03-02 加州理工学院 调节性眼内晶体
CN107106293A (zh) * 2014-08-26 2017-08-29 施菲姆德控股有限责任公司 调节性人工晶状体
CN104720932A (zh) * 2015-03-10 2015-06-24 北京艾克伦医疗科技有限公司 一种人工晶状体囊体及包括其的注射式人工晶状体
CN112135582A (zh) * 2017-12-07 2020-12-25 理查德·F·霍尼斯鲍姆 收缩包裹锚定的和收缩包裹致动的可调节人工晶状体及其植入方法
CN118593189A (zh) * 2023-10-23 2024-09-06 加州理工学院 具有非对称腔室的液体可调节人工晶状体
CN117860431A (zh) * 2024-01-03 2024-04-12 微智医疗器械有限公司 可调节人工晶状体
CN117860432A (zh) * 2024-01-03 2024-04-12 微智医疗器械有限公司 人工晶状体
CN117898858A (zh) * 2024-01-03 2024-04-19 微智医疗器械有限公司 人工晶状体

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