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WO2025143820A1 - Composition cosmétique pour le blanchiment de la peau et la réduction des rides contenant un extrait mixte d'une fleur, d'une branche et d'un fruit de rosa multiflora thunb. en tant que principe actif - Google Patents

Composition cosmétique pour le blanchiment de la peau et la réduction des rides contenant un extrait mixte d'une fleur, d'une branche et d'un fruit de rosa multiflora thunb. en tant que principe actif Download PDF

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Publication number
WO2025143820A1
WO2025143820A1 PCT/KR2024/021187 KR2024021187W WO2025143820A1 WO 2025143820 A1 WO2025143820 A1 WO 2025143820A1 KR 2024021187 W KR2024021187 W KR 2024021187W WO 2025143820 A1 WO2025143820 A1 WO 2025143820A1
Authority
WO
WIPO (PCT)
Prior art keywords
cosmetic composition
flowers
skin whitening
branches
fruits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/KR2024/021187
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English (en)
Korean (ko)
Inventor
박종민
주인환
엄두성
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
We Soo Young
Original Assignee
We Soo Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by We Soo Young filed Critical We Soo Young
Publication of WO2025143820A1 publication Critical patent/WO2025143820A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a cosmetic composition for skin whitening and wrinkle improvement containing a mixed extract of flowers, branches and fruits of a thistle as an effective ingredient.
  • the skin is the outermost epithelial tissue of the body of animals including humans, and it not only protects the body from external impacts but also prevents the invasion of various types of pathogenic substances, thereby protecting the body.
  • This skin is composed of the epidermis, the outermost epithelial tissue, and the dermis, the connective tissue underneath, and melanin pigment is distributed just above the cell division layer among the various cell layers of the epidermis.
  • the dermis layer is mostly composed of collagen, and capillaries, sebaceous glands, and hair follicles are distributed, and subcutaneous fat and muscle layers exist below the dermis.
  • the branches and fruits of the thorn tree may be mixed in a dry weight ratio of 1:3 to 1:7, and more preferably, the branches and fruits of the thorn tree may be mixed in a dry weight ratio of 1:5.
  • the cosmetic composition for skin whitening and wrinkle improvement can be manufactured in any formulation commonly manufactured in the art, and for example, can be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, oil, powder foundation, emulsion foundation, wax foundation, and spray, and more specifically, can be manufactured in the cosmetic formulation of skin, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, eye cream, moisture cream, hand cream, essence, nutrition essence, pack, cleansing foam, cleansing water, cleansing lotion, cleansing cream, body lotion, body cleanser, soap, or powder, but is not limited thereto.
  • the formulation of the cosmetic composition is a paste, cream or gel
  • animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component.
  • the formulation of the cosmetic composition is a powder or spray
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and particularly in the case of a spray, a propellant such as chlorofluorohydrocarbon, propane/butane or dimethyl ether may be additionally included.
  • liquid diluents such as water, ethanol or propylene glycol
  • suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth, etc. can be used as carrier components.
  • Rosa multiflora Thunb used in the present invention is a shrub belonging to the rose family, a deciduous broadleaf tree commonly found in mountains and fields throughout Korea. It is mainly used for ornamental purposes, and the petals are edible and the fruit is used for medicinal purposes.
  • the fruit of the Rosa multiflora Thunb is called Yeongsil ( ⁇ ), a herbal medicine, and is known to be used for insomnia, amnesia, liver disease, diabetes, etc.
  • Another aspect of the present invention provides a method for producing a cosmetic composition for skin whitening and wrinkle improvement, comprising: a step of extracting flowers, branches, and fruits of a thorn tree, respectively, in 70% ethanol at 100°C; a step of filtering each extract using a filter paper, concentrating under reduced pressure, and then freeze-drying to obtain powders of flowers, branches, and fruits of a thorn tree; a step of mixing the powders of flowers, branches, and fruits of the thorn tree in a weight ratio of 1:1:1 to produce a mixed extract; and a step of producing a cosmetic composition comprising the mixed extract.
  • Another aspect of the present invention provides a health functional food composition for skin whitening and wrinkle improvement containing a mixed extract of flowers, branches, and fruits of Rosa multiflora Thunb as an effective ingredient.
  • the flower, branch, and fruit mixed extracts of the thistle tree are as described above.
  • the above health functional food composition is preferably manufactured in one of the formulations selected from powder, granules, pills, tablets, capsules, candy, syrup, and beverage, but is not limited thereto.
  • the health functional food composition of the present invention can be manufactured by adding the new variety of watermelon as is or mixing it with other foods or food ingredients, and can be manufactured appropriately according to a conventional method.
  • Figure 2 shows the ABTS radical scavenging activity of the mixed extracts of flowers, branches, and fruits of the common thorn at different concentrations.
  • Figure 4 shows the inhibition of elastase activity according to the concentration of mixed extracts of flowers, branches, and fruits of the common thorn.
  • Figure 5 shows the cell viability of B16F10 cells treated with a mixture of extracts of flowers, branches, and fruits of the common thorn.
  • Figure 7 shows the effect of mixed extracts of flowers, branches, and fruits of the common thorn on the expression of tyrosinase mRNA in ⁇ -MSH-induced B16F10 cells.
  • Figure 8 shows the effect of mixed extracts of flowers, branches, and fruits of the common thorn on MITF mRNA expression levels in ⁇ -MSH-induced B16F10 cells.
  • Figure 9 shows the effect of mixed extracts of flowers, branches, and fruits of the common thorn on TRP1 mRNA expression levels in ⁇ -MSH-induced B16F10 cells.
  • Figure 11 shows the effect of mixed extracts of flowers, branches, and fruits of the common thorn on the expression of tyrosinase protein in ⁇ -MSH-induced B16F10 cells.
  • Figure 13 shows the effect of mixed extracts of flowers, branches, and fruits of the common thorn on TRP1 protein expression in ⁇ -MSH-induced B16F10 cells.
  • One aspect of the present invention provides a cosmetic composition for skin whitening and wrinkle improvement containing a mixed extract of flowers, branches, and fruits of Rosa multiflora Thunb as an effective ingredient.
  • the concentration of the mixed extract of flowers, branches, and fruits of the thistle tree can be 100 ⁇ g/mL.
  • the extract may be extracted using 65 to 75% (v/v) of ethanol as an extraction solvent.
  • the flowers and fruits of the thistle tree may be mixed at a dry weight ratio of 1:5.
  • the branches and fruits of the thistle tree may be mixed at a dry weight ratio of 1:5.
  • Another aspect of the present invention provides a health functional food composition for skin whitening and wrinkle improvement containing a mixed extract of flowers, branches, and fruits of Rosa multiflora Thunb as an effective ingredient.
  • qPCRBIO SyGreen Blue Mix Lo-ROX was from PCR Biosystems (USA)
  • RIPA lysis and extraction buffer RIPA lysis and extraction buffer
  • PierceTM BCA protein assay Kit PierceTM BCA protein assay Kit
  • 10% ammonium persulfate were from Thermo Fisher Scientific (USA).
  • the extraction mantle was manufactured by Misung Scientific (Korea), the rotary vacuum evaporator was manufactured by EYELA (Japan), the freeze dryer was manufactured by ilShinbiobase (Korea), the CO2 incubator, autoclave (deep-freezer was manufactured by Sanyo (Japan), the clean bench was manufactured by Vision scientific (Korea), the vortex mixer, centrifuge, and ice-maker were manufactured by Vision scientific (Korea), the plate shaker was manufactured by Lab-Line (USA), the micro plate reader was manufactured by Molecular Devices (USA), the nanodrop was manufactured by Thermo Fisher Scientific (USA), the PCR cycler; alpha cycler 1 PCRmax was manufactured by PCRmax (UK), the real-time PCR cycler; Exicycler 96 was manufactured by Bioneer (Korea), chemidoc; and the fusion FX was manufactured by Vilber Lourmat (France).
  • Misung Scientific Karl Scientific
  • the rotary vacuum evaporator was manufactured by EYELA (J
  • a mixed extract of flowers, branches, and fruits of the common thorn was prepared at a concentration of 1 mg/mL, and 0.5 mL of 50% Folin-Ciocalteu's phenol reagent was added to 1 mL of the sample and reacted at room temperature for 3 minutes.
  • 1 mL of a saturated Na2CO3 solution and 7.5 mL of distilled water were mixed sequentially in the reaction solution, allowed to stand for 30 minutes, and centrifuged at 14,000 g for 10 minutes. The supernatant was collected and the absorbance was measured at a wavelength of 760 nm.
  • the total phenol content was determined according to a calibration curve created using gallic acid as a standard.
  • the total flavonoid content in the extract was measured using quercetin as a standard substance, and was found to be 18.08 ⁇ 0.27 mg QE/g (QE is quercetin equivalent).
  • the final concentrations of the mixed extracts of flowers, branches, and fruits of the common thorn were diluted to 1, 10, 100, and 1000 ⁇ g/mL, and the ABTS solution was prepared by mixing 7.4 mM ABTS (2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) and 2.6 mM potassium persulphate.
  • the solution was left in the dark for one day to form cations (ABTS+).
  • the absorbance was measured at 732 nm.
  • the solution was diluted to an absorbance value of 1.5 or less.
  • the degree of inhibition of elastase activity was expressed by calculating the absorbance of the sample-added group and the control group using the following equation.
  • the extract showed a concentration-dependent and significant decrease compared to the control group at a concentration of 100 ⁇ g/mL or higher, as shown in Table 11 below (Fig. 8).
  • the extract showed a concentration-dependent and significant decrease compared to the control group at a concentration of 25 ⁇ g/mL or higher, as shown in Table 13 below (Fig. 10).
  • the extract showed a concentration-dependent and significant decrease compared to the control group at a concentration of 100 ⁇ g/mL or higher, as shown in Table 15 below (Fig. 12).
  • the extract showed a concentration-dependent and significant decrease compared to the control group at a concentration of 25 ⁇ g/mL or higher, as shown in Table 16 below (Fig. 13).
  • Example 12 Comparison of antioxidant efficacy according to the weight ratio of thorny ash flowers, branches, and fruits
  • the antioxidant efficacy according to each weight ratio was compared.
  • the same method as described in Preparation Example 2 was used to prepare the sample, and the mass (g) of the flower, branch, and fruit of each sample was combined as shown in Table 17 below, and the antioxidant efficacy was measured using ABTS radical scavenging activity, which is more suitable for evaluating the efficacy of hydrophilic antioxidants.
  • the present invention relates to a cosmetic composition for skin whitening and wrinkle improvement containing a mixed extract of flowers, branches, and fruits of Rosa multiflora Thunb. as an effective ingredient.
  • the cosmetic composition of the present invention has a total polyphenol content of 134.63 mg GAE/g and a total flavonoid content of 18.08 mg GAE/g, and has been confirmed to exhibit scavenging effects on DPPH radicals and ABTS radicals, inhibitory effects on tyrosinase and elastase activities, reduction in melanin synthesis, and reduction in gene and protein expression levels of tyrosinase, MITF, TRP1, and TRP2, thereby exhibiting skin whitening and wrinkle improvement effects. Therefore, the composition of the present invention can be usefully used as a material for cosmetics and health functional foods for skin whitening and wrinkle improvement.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition cosmétique pour le blanchiment de la peau et la réduction des rides contenant un extrait mixte d'une fleur, d'une branche et d'un fruit de Rosa multiflora Thunb. en tant que principe actif. La composition cosmétique de la présente invention présente une teneur totale en polyphénols de 134,63 mg EAG/g et une teneur totale en flavonoïdes de 18,08 mg EAG/g, et présente une capacité à piéger les radicaux DPPH et les radicaux ABTS, une capacité à inhiber les activités de la tyrosinase et de l'élastase, un effet de réduction de la synthèse de la mélanine, et un effet de diminution des niveaux d'expression de la tyrosinase, MITF, TRP1 et TRP2 à la fois au niveau du gène et de la protéine, présentant ainsi des effets de blanchiment de la peau et de réduction des rides. En conséquence, la composition de la présente invention peut être efficacement utilisée comme substance pour des produits cosmétiques et des aliments fonctionnels pour la santé destinés au blanchiment de la peau et à la réduction des rides.
PCT/KR2024/021187 2023-12-28 2024-12-26 Composition cosmétique pour le blanchiment de la peau et la réduction des rides contenant un extrait mixte d'une fleur, d'une branche et d'un fruit de rosa multiflora thunb. en tant que principe actif Pending WO2025143820A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2023-0195222 2023-12-28
KR20230195222 2023-12-28

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Publication Number Publication Date
WO2025143820A1 true WO2025143820A1 (fr) 2025-07-03

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KR (1) KR20250105225A (fr)
WO (1) WO2025143820A1 (fr)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110041616A (ko) * 2009-10-16 2011-04-22 (주) 이지함 항산화 능을 갖는 영실 분획물을 유효성분으로 함유하는 미백용 또는 주름개선용 화장료 조성물
WO2017057929A1 (fr) * 2015-10-01 2017-04-06 코스맥스 주식회사 Composition cosmétique pour la prévention du vieillissement de la peau et l'atténuation des rides contenant un extrait de mélange de fruits de rosa multiflora thunberg et de graines de kochia scoparia schrader
KR20180128774A (ko) * 2017-05-24 2018-12-04 휴먼코스메틱 주식회사 꽃차 추출물을 함유하는 항산화, 미백 및 주름 개선을 위한 조성물
KR20190090571A (ko) * 2018-01-25 2019-08-02 남부대학교산학협력단 찔레나무 추출물을 함유하는 항균, 항산화 및 항염증 조성물
CN114303944A (zh) * 2020-09-30 2022-04-12 伽蓝（集团）股份有限公司 细梗蔷薇愈伤组织培养基及提取物、制备方法和应用
KR20220116780A (ko) * 2021-02-15 2022-08-23 재단법인 경남한방항노화연구원 찔레꽃을 이용한 미백용 조성물의 제조 방법
KR20220157217A (ko) * 2021-05-20 2022-11-29 휴먼코스메틱 주식회사 찔레꽃 추출물을 포함하는 피부 주름 또는 피부 열노화 예방 또는 개선용 조성물
KR102481945B1 (ko) * 2022-05-10 2022-12-29 주식회사 네이처팩토리 천연 복합추출물을 유효성분으로 함유하는 두피 및 모발용 화장료 조성물

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110041616A (ko) * 2009-10-16 2011-04-22 (주) 이지함 항산화 능을 갖는 영실 분획물을 유효성분으로 함유하는 미백용 또는 주름개선용 화장료 조성물
WO2017057929A1 (fr) * 2015-10-01 2017-04-06 코스맥스 주식회사 Composition cosmétique pour la prévention du vieillissement de la peau et l'atténuation des rides contenant un extrait de mélange de fruits de rosa multiflora thunberg et de graines de kochia scoparia schrader
KR20180128774A (ko) * 2017-05-24 2018-12-04 휴먼코스메틱 주식회사 꽃차 추출물을 함유하는 항산화, 미백 및 주름 개선을 위한 조성물
KR20190090571A (ko) * 2018-01-25 2019-08-02 남부대학교산학협력단 찔레나무 추출물을 함유하는 항균, 항산화 및 항염증 조성물
CN114303944A (zh) * 2020-09-30 2022-04-12 伽蓝（集团）股份有限公司 细梗蔷薇愈伤组织培养基及提取物、制备方法和应用
KR20220116780A (ko) * 2021-02-15 2022-08-23 재단법인 경남한방항노화연구원 찔레꽃을 이용한 미백용 조성물의 제조 방법
KR20220157217A (ko) * 2021-05-20 2022-11-29 휴먼코스메틱 주식회사 찔레꽃 추출물을 포함하는 피부 주름 또는 피부 열노화 예방 또는 개선용 조성물
KR102481945B1 (ko) * 2022-05-10 2022-12-29 주식회사 네이처팩토리 천연 복합추출물을 유효성분으로 함유하는 두피 및 모발용 화장료 조성물

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