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WO2025039024A1 - Autonomic nervous system neuromodulation - Google Patents

Autonomic nervous system neuromodulation Download PDF

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Publication number
WO2025039024A1
WO2025039024A1 PCT/AU2024/050470 AU2024050470W WO2025039024A1 WO 2025039024 A1 WO2025039024 A1 WO 2025039024A1 AU 2024050470 W AU2024050470 W AU 2024050470W WO 2025039024 A1 WO2025039024 A1 WO 2025039024A1
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Prior art keywords
autonomic
stimulation
neuromodulation
nervous system
limited
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French (fr)
Inventor
Vahid MOHABBATI
Parsa MOHABBATI
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4035—Evaluating the autonomic nervous system
    • A—HUMAN NECESSITIES
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    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
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    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
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    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
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    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
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    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
    • A—HUMAN NECESSITIES
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    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A61N1/36075—Headache or migraine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36132—Control systems using patient feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37235—Aspects of the external programmer
    • A61N1/37247—User interfaces, e.g. input or presentation means
    • A—HUMAN NECESSITIES
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    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment
    • A—HUMAN NECESSITIES
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    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

Definitions

  • This invention bridges neuroscience, medical technology, and biomedical engineering to potentially address conditions related to autonomic dysregulation.
  • the autonomic nervous system plays a pivotal role in maintaining internal homeostasis, regulating vital functions such as heart rate, blood pressure, digestion, and respiratory rate.
  • disruptions in autonomic balance can lead to a range of debilitating conditions collectively referred to as autonomic dysregulation.
  • autonomic dysregulation These conditions encompass disorders like orthostatic hypotension, vasovagal syncope, and cardiac arrhythmias, which profoundly impact patients' quality of life and pose significant challenges for traditional therapeutic approaches.
  • the ANS is also involved in our fight-flight response and subsequently in many painful conditions involving different body parts or organs, including but not limited to cluster or migraine headaches, Complex Regional Pain Syndrome (CRPS), visceral pain of chest, abdomen and or pelvis, and ischemic pain due to peripheral vascular disease.
  • CRPS Complex Regional Pain Syndrome
  • DRG-S Dorsal Root Ganglion
  • Stimulating DRG has its limitations such as unwanted motor stimulation, sensory stimulation (induction of paraesthesia) that can be intolerable for some patients and lead migration and fracture.
  • Autonomic Nervous System Neuromodulation emerges as a promising solution to these challenges. By combining principles from neuroengineering, neuromodulation, and biomedical technology, this novel approach aims to restore autonomic equilibrium through targeted modulation of the sympathetic chain. This innovation holds the potential to revolutionise the treatment landscape in several ways:
  • the stimulator Unlike broader systemic interventions, the stimulator employs targeted electrode placement and stimulation techniques to selectively target specific ANS neural pathways responsible for autonomic regulation. This precision enables tailored modulation and potential restoration of autonomic balance.
  • Surgical interventions for autonomic dysregulation can carry substantial risks.
  • ANS stimulation it was proven to be technically easier and need less skills compared to surgical sympathectomies or even DRG-Stim. Risk of lead migration and lead fracture will also be minimised.
  • the ANS stimulator offers a less invasive alternative, utilising minimally invasive implantation techniques to minimize surgical complications and patient discomfort.
  • Patient-Centric Care The stimulator's customisable parameters allow for individualised treatment, catering to the unique autonomic profiles of each patient. This patient-centric approach acknowledges the variability in autonomic dysfunction presentation and optimises treatment efficacy. Stimulators parameters such as mAmp, frequency, pulse width etc can be tailored to patients needs to achieve best outcomes.
  • the Autonomic Nervous System Neuromodulation is an innovative breakthrough in neuroengineering and neuromodulation technology designed to address autonomic dysregulati on-related disorders.
  • This device operates on the fundamental principle of targeted neural modulation, interfacing with the autonomic nervous system through precise stimulation of the sympathetic chain based on the patient's symptoms and organ involvement.
  • this invention holds the potential to revolutionize the treatment landscape for conditions including but not limited to pain of head, neck, upper limb, chest, abdomen, pelvis and lower limb as well as acute and chronic heart failure, post-traumatic stress disorder (PTSD), gastrointestinal and genitourinary system disorders and dysfunctions including pain and dysmotility syndromes, and peripheral vascular disease and ischemic pain.
  • PTSD post-traumatic stress disorder
  • gastrointestinal and genitourinary system disorders and dysfunctions including pain and dysmotility syndromes
  • peripheral vascular disease and ischemic pain peripheral vascular disease and ischemic pain.
  • the stimulator employs biocompatible electrodes strategically positioned along the sympathetic chain, capitalizing on our understanding of autonomic pathways. It harnesses the intricate interplay between neural networks to selectively modulate autonomic functions. This principle is rooted in the concept of restoring equilibrium within the autonomic nervous system by stimulating key nodes associated with sympathetic nervous system function for example heart rate variability, vasomotor tone, sudomotor function and respiratory rhythm.
  • the invention is intended for individuals grappling with autonomic dysregulati on-related conditions, where conventional treatments have proven inadequate or fraught with failure or side effects. It finds application in both clinical and research settings. Clinically, it offers a novel therapeutic avenue for patients seeking relief from autonomic malfunctions. In research, it serves as a platform for further understanding of autonomic neurophysiology, it’s relationship to modulation of pain and other symptoms and refining stimulation techniques.
  • the stimulator's operation revolves around its ability to deliver precise electrical pulses to targeted regions of the autonomic nervous system from Tito T3 (Stellate Ganglion) to Splanchnic nerves (T10/T11/T12) to Lumbar sympathetic plexus (L2/L3/L4) to Superior Hypogastric Plexus (L5/S1) to Ganglion Impar (Sacro-coccygeal plexus).
  • T3 tellate Ganglion
  • Splanchnic nerves T10/T11/T12
  • L2/L3/L4 Superior Hypogastric Plexus
  • L5/S1 Superior Hypogastric Plexus
  • Ganglion Impar Sacro-coccygeal plexus
  • the electrodes are implanted in proximity to autonomic neural pathways. These electrodes are then connected to a control unit (Impulse Generator- IPG) that allows for customisation of stimulation parameters.
  • Impulse Generator- IPG By manipulating pulse frequency, amplitude, pulse width and duty cycles, clinicians can tailor
  • ANSNM Autonomic Nervous System Neuromodulation
  • DRG-Stimulattor used in pain medicine, but with a distinct focus on modulating autonomic functions rather than dorsal spinal column or DRG.
  • traditional stimulators involve electrode implantation on nerve sites to influence pain perception
  • the ANSNM employs a similar concept to target autonomic pathways for the regulation of physiological functions.
  • Electrode Placement In the case of an ANSNM, electrodes are placed near specific autonomic nerve pathways along the vertebral bodies using a Touhey needle under direct fluoroscopy. These pathways are identified based on the patient's history, examination, advanced neuroimaging, and neurophysiological techniques, ensuring accurate targeting of autonomic nodes responsible for symptoms and organs involved. For example, a patient with lower limb CRPS, will receive ANSNM at L2/L3/L4 on the affected side or a person with chronic congestive heart failure will receive a T2 sympathetic ANSNM on the left side.
  • Both types of stimulators deliver controlled electrical pulses to the nerve via the implanted electrodes. In traditional stimulators, these pulses interfere with pain signals, creating a tingling sensation that "overrides” pain perception.
  • the electrical pulses modulate autonomic nerve activity. By precisely stimulating or inhibiting certain autonomic pathways, the ANSNM aims to restore balance within the autonomic nervous system, improving its regulation of bodily functions.
  • Stimulation Parameters The parameters of stimulation are crucial for both stimulator types. In traditional stimulators, factors such as pulse frequency, amplitude, and pulse width are adjusted to achieve optimal pain relief for the individual. Similarly, in the ANSNM, these parameters are customized to address specific autonomic dysregulation patterns. For example, altering the frequency and amplitude of electrical pulses can influence heart rate variability, while adjusting pulse width can impact vasomotor tone. 4. Individualized Treatment: Both stimulator types emphasize individualized treatment. Traditional stimulators allow patients to adjust stimulation settings based on their pain levels and preferences. Similarly, the ANSNM permits tailored modulation of autonomic functions, recognizing the variability in autonomic dysfunction presentations among individuals.
  • Minimally Invasive Implantation The implantation procedure for both stimulator types is minimally invasive, involving the placement of electrodes through a surgical procedure. This approach reduces risks and promotes quicker recovery times for patients.

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Abstract

Autonomic Nervous System Neuromodulation represents a pioneering endeavour in neuromodulation technology. By selectively interfacing with the autonomic nervous system, this new technology offers a prospective avenue for ameliorating conditions characterised by autonomic dysregulation including but not limited to pain of head and neck, upper limb, chest, abdomen, pelvis, and lower limb, post-traumatic stress disorder (PTSD), acute and chronic heart failure, gastrointestinal and genitourinary system dysmotility, and peripheral vascular disease. By employing targeted stimulation of intricate autonomic neural pathways, it aspires to reinstate equilibrium with autonomic functions. This innovation bears the potential to significantly enhance the quality of life for individuals grappling with a spectrum of autonomic disorders, ushering in a paradigm shift in neurological therapies.

Description

TITLE OF YOUR INVENTION
Autonomic Nervous System Neuromodulation
TECHNICAL FIELD
This invention bridges neuroscience, medical technology, and biomedical engineering to potentially address conditions related to autonomic dysregulation.
BACKGROUND OF THE INVENTION
The autonomic nervous system (ANS) plays a pivotal role in maintaining internal homeostasis, regulating vital functions such as heart rate, blood pressure, digestion, and respiratory rate. However, disruptions in autonomic balance can lead to a range of debilitating conditions collectively referred to as autonomic dysregulation. These conditions encompass disorders like orthostatic hypotension, vasovagal syncope, and cardiac arrhythmias, which profoundly impact patients' quality of life and pose significant challenges for traditional therapeutic approaches. The ANS is also involved in our fight-flight response and subsequently in many painful conditions involving different body parts or organs, including but not limited to cluster or migraine headaches, Complex Regional Pain Syndrome (CRPS), visceral pain of chest, abdomen and or pelvis, and ischemic pain due to peripheral vascular disease.
Conventional treatment modalities for autonomic dysregulation often target symptoms rather than addressing underlying neural imbalances. Medications can be limited by side effects and have a temporary and partial effect. Chemical blocks using needle techniques may have temporary benefits. Surgical sympathectomies may carry significant risks. This calls for innovative interventions capable of recalibrating autonomic function while minimising invasiveness and adverse effects. Stimulation of Dorsal Root Ganglion (DRG-S) has been employed and postulated to be a useful technique in recruiting sympathetic chain in literature. DRG-S uses implantable electrodes over DRG of the spinal nerve roots (consisting of sensory/motor and sympathetic fibres) to achieve this. DRG-S is a technically challenging and a high-risk procedure. Stimulating DRG has its limitations such as unwanted motor stimulation, sensory stimulation (induction of paraesthesia) that can be intolerable for some patients and lead migration and fracture. Autonomic Nervous System Neuromodulation emerges as a promising solution to these challenges. By combining principles from neuroengineering, neuromodulation, and biomedical technology, this novel approach aims to restore autonomic equilibrium through targeted modulation of the sympathetic chain. This innovation holds the potential to revolutionise the treatment landscape in several ways:
Precise Modulation of Autonomic Pathways: Unlike broader systemic interventions, the stimulator employs targeted electrode placement and stimulation techniques to selectively target specific ANS neural pathways responsible for autonomic regulation. This precision enables tailored modulation and potential restoration of autonomic balance.
Minimally Invasive Approach: Surgical interventions for autonomic dysregulation can carry substantial risks. In our cadaveric studies of targeted ANS stimulation it was proven to be technically easier and need less skills compared to surgical sympathectomies or even DRG-Stim. Risk of lead migration and lead fracture will also be minimised. The ANS stimulator offers a less invasive alternative, utilising minimally invasive implantation techniques to minimize surgical complications and patient discomfort.
Holistic Impact on Autonomic Functions: By directly influencing the autonomic nervous system, this approach has the potential to impact multiple physiological processes simultaneously. This approach addresses the root causes of autonomic dysregulation in a more profound and direct way, potentially leading to more comprehensive and enduring therapeutic outcomes.
Patient-Centric Care: The stimulator's customisable parameters allow for individualised treatment, catering to the unique autonomic profiles of each patient. This patient-centric approach acknowledges the variability in autonomic dysfunction presentation and optimises treatment efficacy. Stimulators parameters such as mAmp, frequency, pulse width etc can be tailored to patients needs to achieve best outcomes.
Reduced Dependence on Pharmaceuticals: Patients with autonomic dysregulation often rely on a cocktail of medications with varying degrees of effectiveness. The stimulator offers the prospect of reducing or even eliminating dependence on pharmaceutical agents, thereby alleviating concerns about side effects and drug interactions. In conclusion, Autonomic Nervous System Neuromodulation represents an innovation poised to redefine the management of autonomic dysregulati on-related disorders. By leveraging the synergy of neuroengineering, neuromodulation, and biomedical technology, this approach holds the promise of providing patients with more effective, personalised, and minimally invasive treatment options. As ongoing research and clinical trials unfold, the potential advantages of this technology could lead to a paradigm shift in addressing autonomic dysregulation and enhancing the well-being of countless individuals.
SUMMARY OF THE INVENTION
The Autonomic Nervous System Neuromodulation is an innovative breakthrough in neuroengineering and neuromodulation technology designed to address autonomic dysregulati on-related disorders. This device operates on the fundamental principle of targeted neural modulation, interfacing with the autonomic nervous system through precise stimulation of the sympathetic chain based on the patient's symptoms and organ involvement. By offering a minimally invasive, patient-centric approach, this invention holds the potential to revolutionize the treatment landscape for conditions including but not limited to pain of head, neck, upper limb, chest, abdomen, pelvis and lower limb as well as acute and chronic heart failure, post-traumatic stress disorder (PTSD), gastrointestinal and genitourinary system disorders and dysfunctions including pain and dysmotility syndromes, and peripheral vascular disease and ischemic pain.
The stimulator employs biocompatible electrodes strategically positioned along the sympathetic chain, capitalizing on our understanding of autonomic pathways. It harnesses the intricate interplay between neural networks to selectively modulate autonomic functions. This principle is rooted in the concept of restoring equilibrium within the autonomic nervous system by stimulating key nodes associated with sympathetic nervous system function for example heart rate variability, vasomotor tone, sudomotor function and respiratory rhythm.
The invention is intended for individuals grappling with autonomic dysregulati on-related conditions, where conventional treatments have proven inadequate or fraught with failure or side effects. It finds application in both clinical and research settings. Clinically, it offers a novel therapeutic avenue for patients seeking relief from autonomic malfunctions. In research, it serves as a platform for further understanding of autonomic neurophysiology, it’s relationship to modulation of pain and other symptoms and refining stimulation techniques.
The stimulator's operation revolves around its ability to deliver precise electrical pulses to targeted regions of the autonomic nervous system from Tito T3 (Stellate Ganglion) to Splanchnic nerves (T10/T11/T12) to Lumbar sympathetic plexus (L2/L3/L4) to Superior Hypogastric Plexus (L5/S1) to Ganglion Impar (Sacro-coccygeal plexus). Through a minimally invasive surgical procedure, the electrodes are implanted in proximity to autonomic neural pathways. These electrodes are then connected to a control unit (Impulse Generator- IPG) that allows for customisation of stimulation parameters. By manipulating pulse frequency, amplitude, pulse width and duty cycles, clinicians can tailor the stimulation to address specific autonomic imbalances. The device's ability to interface with the autonomic nervous system at a neural level enables real-time adjustment and optimisation.
DETAILED DESCRIPTION OF EMBODIMENTS
Autonomic Nervous System Neuromodulation (ANSNM) functions on principles like traditional spinal cord stimulators, DRG-Stimulattor used in pain medicine, but with a distinct focus on modulating autonomic functions rather than dorsal spinal column or DRG. Just as traditional stimulators involve electrode implantation on nerve sites to influence pain perception, the ANSNM employs a similar concept to target autonomic pathways for the regulation of physiological functions.
Electrode Placement: In the case of an ANSNM, electrodes are placed near specific autonomic nerve pathways along the vertebral bodies using a Touhey needle under direct fluoroscopy. These pathways are identified based on the patient's history, examination, advanced neuroimaging, and neurophysiological techniques, ensuring accurate targeting of autonomic nodes responsible for symptoms and organs involved. For example, a patient with lower limb CRPS, will receive ANSNM at L2/L3/L4 on the affected side or a person with chronic congestive heart failure will receive a T2 sympathetic ANSNM on the left side.
Neural Modulation: Both types of stimulators deliver controlled electrical pulses to the nerve via the implanted electrodes. In traditional stimulators, these pulses interfere with pain signals, creating a tingling sensation that "overrides" pain perception. In the ANSNM, the electrical pulses modulate autonomic nerve activity. By precisely stimulating or inhibiting certain autonomic pathways, the ANSNM aims to restore balance within the autonomic nervous system, improving its regulation of bodily functions.
Stimulation Parameters: The parameters of stimulation are crucial for both stimulator types. In traditional stimulators, factors such as pulse frequency, amplitude, and pulse width are adjusted to achieve optimal pain relief for the individual. Similarly, in the ANSNM, these parameters are customized to address specific autonomic dysregulation patterns. For example, altering the frequency and amplitude of electrical pulses can influence heart rate variability, while adjusting pulse width can impact vasomotor tone. 4. Individualized Treatment: Both stimulator types emphasize individualized treatment. Traditional stimulators allow patients to adjust stimulation settings based on their pain levels and preferences. Similarly, the ANSNM permits tailored modulation of autonomic functions, recognizing the variability in autonomic dysfunction presentations among individuals.
Minimally Invasive Implantation: The implantation procedure for both stimulator types is minimally invasive, involving the placement of electrodes through a surgical procedure. This approach reduces risks and promotes quicker recovery times for patients.

Claims

1. Neuromodulation which can specially stimulate autonomic nerves
2. A plurality of biocompatible electrodes configured for implantation along the autonomic nerves
3. An electrode control unit adapted to generate electrical pulses and control stimulation parameters
4. Electrode pulse emission across the entire electromagnetic frequency spectrum
5. A neural pathway mapping system for identifying autonomic neural pathways associated with physiological functions
6. A user-friendly stimulation customisation interface allowing adjustment of pulse frequency, amplitude, and pulse width
7. A closed-loop system to monitor autonomic responses and optimise stimulation settings depending on critical events
8. A biofeedback integration which can integrate biometrics including but not limited to heart rate and respiration for bi-directional communication
9. An autonomic regulation algorithm that adapts stimulation patterns based on real-time autonomic feedback, including but not limited to machine learning and artificial intelligence
10. An anatomical imaging module to facilitate precise electrode placement along the spinal cord
11. A multi-modal stimulation integrating other types of neuromodulation, including but not limited to transcranial magnetic stimulation or vagus nerve stimulation
12. A patient-specific calibration module to tailor stimulation parameters to individual autonomic profiles
13. A data storage and analysis module integration for historical autonomic responses
14. A remote wireless programming interface enabling remote adjustments of stimulation parameters
PCT/AU2024/050470 2023-08-24 2024-05-13 Autonomic nervous system neuromodulation Pending WO2025039024A1 (en)

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Citations (5)

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US20090270935A1 (en) * 2008-04-29 2009-10-29 Weiying Zhao Systems and methods for selectively stimulating nerve roots
US20100228310A1 (en) * 2009-03-09 2010-09-09 Shuros Allan C Systems and methods for autonomic nerve modulation
US20150039058A1 (en) * 2011-07-11 2015-02-05 Interventional Autonomics Corporation System and method for neuromodulation
US20210069511A1 (en) * 2017-12-11 2021-03-11 Galvani Bioelectronics Limited Treatment and prevention of cardiac dysfunction
US20210196957A1 (en) * 2014-06-21 2021-07-01 Nalu Medical, Inc. Method and apparatus for neuromodulation treatments of pain and other conditions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090270935A1 (en) * 2008-04-29 2009-10-29 Weiying Zhao Systems and methods for selectively stimulating nerve roots
US20100228310A1 (en) * 2009-03-09 2010-09-09 Shuros Allan C Systems and methods for autonomic nerve modulation
US20150039058A1 (en) * 2011-07-11 2015-02-05 Interventional Autonomics Corporation System and method for neuromodulation
US20210196957A1 (en) * 2014-06-21 2021-07-01 Nalu Medical, Inc. Method and apparatus for neuromodulation treatments of pain and other conditions
US20210069511A1 (en) * 2017-12-11 2021-03-11 Galvani Bioelectronics Limited Treatment and prevention of cardiac dysfunction

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