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WO2025037309A1 - Dispositif pouvant être porté sur soi et appareil et procédé permettant de réduire les niveaux de cortisol - Google Patents

Dispositif pouvant être porté sur soi et appareil et procédé permettant de réduire les niveaux de cortisol Download PDF

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Publication number
WO2025037309A1
WO2025037309A1 PCT/IL2024/050811 IL2024050811W WO2025037309A1 WO 2025037309 A1 WO2025037309 A1 WO 2025037309A1 IL 2024050811 W IL2024050811 W IL 2024050811W WO 2025037309 A1 WO2025037309 A1 WO 2025037309A1
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WIPO (PCT)
Prior art keywords
user
stress
skin
data
activity
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English (en)
Inventor
Ram HERSTEIN
Ofer Melamed
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PBS Consulting Ltd
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PBS Consulting Ltd
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/375—Electroencephalography [EEG] using biofeedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A61B5/0533—Measuring galvanic skin response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/486—Biofeedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6815—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898—Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor

Definitions

  • the present invention relates to Well-being, aging, preventive therapeutic, esthetic, treatment, diagnostics, and prognosis, of the human integumentary system. More specifically, the invention allows users to receive suggestions to control their mindset for better health in several areas, including their overall stress, facial skin status, obesity prevention, and alopecia process mitigation.
  • Cortisol is a hormone produced by the adrenal glands, which are located on top of kidneys. It plays a significant role in a variety of bodily functions, including:
  • Cortisol helps regulate how the body converts proteins, carbohydrates, and fats from your diet into energy.
  • Stress Response Known as the "stress hormone,” cortisol levels increase in response to stress, helping your body manage and adapt to stressors.
  • Cortisol helps maintain blood pressure and cardiovascular function.
  • Cortisol levels fluctuate throughout the day, typically peaking in the morning (around 8 a.m.) and gradually declining throughout the day, reaching their lowest levels around midnight. This daily pattern is known as the diurnal rhythm.
  • cortisol levels It is important to reduce cortisol levels for several reasons, as prolonged elevated cortisol can have various negative effects on the body and overall health:
  • Elevated cortisol levels can lead to increased appetite and cravings for high-calorie foods, contributing to weight gain and obesity. Lowering cortisol can help maintain a healthy weight.
  • Immune Function Chronic high cortisol suppresses the immune system, making the body more susceptible to infections and illnesses. Reducing cortisol can enhance immune function.
  • Sleep Quality High cortisol levels can disrupt sleep patterns, leading to insomnia or poor-quality sleep. Lower cortisol levels promote better sleep.
  • Blood Pressure and Heart Health Prolonged high cortisol levels can increase blood pressure and contribute to cardiovascular diseases. Reducing cortisol can help maintain healthy blood pressure and heart function.
  • Bone Health Elevated cortisol can lead to decreased bone density and an increased risk of osteoporosis. Lowering cortisol levels supports better bone health.
  • cortisol levels can increase inflammation in the body, exacerbating pain and chronic inflammatory conditions. Reducing cortisol can alleviate inflammation and related pain. By managing and reducing cortisol levels, individuals can improve their overall health, prevent chronic diseases, and enhance their quality of life.
  • Skin indications allow to follow the skin condition by measuring and monitoring blood components ions, minerals, hormones, hydration, and skin condition, its hydration, shape, and texture .
  • Skin condition relates to the mental state. It is profound in patients with stress disorders. Skin substances secret to the blood and influence the skin are controlled by the brain (state of mind), such as cortisol. Prolonged secretion of cortisol (as a result of stress) affects the health of the hair, its density and even causes it to whiten. In a state of prolonged secretion of cortisol, many hairs enter the resting phase at the same time. After a few months, many hairs will fall out together, followed by areas of sparse hair. Additionally, prolonged secretion of cortisol causes the suppression of the secretion of other hormones, and the result is an increase in appetite, and in particular an increase in the desire for sweet and fatty foods.
  • Additional technologies include: smartphone technologies for dermatology, Highly accurate skin micro-relief (texture) and pore analysis, technologies to evaluate the level of wrinkle and sagging, invisible ultra-violet or near-infrared light, we can capture images of various skin conditions (moisture levels), Visualization of potential dark spots using UV rays, skin’s clarity level with the internal reflection light, skin’s inner structure and conditions using “light”, epidermis cells and melanin (A confocal biomicroscope - reproduce skin’s inner structure in three dimensions using multiple horizontal cross-sectional images captured at different depths, dermal collagen and elastin fibers, real-time measurement technologies are used for tracking heart beats or sports activities (temperatures) .Machine and deep learning were used to classify and diagnose the condition of skin for skin disease. Skin Therapeutic includes pastes, mud, minerals, pharma, and more. Yet, the mental source of skin deterioration is still missing or definitely needs to be optimized.
  • Mindfulness therapy is a new discipline that recommends to control the mindset to treat skin conditions. Studies show that skin diseases such as psoriasis were reduced significantly after such mindset training.
  • the mindset can be measured by brain activity techniques such as EEG.
  • FNIRS Functional Near-Infrared Spectroscopy
  • HPA hypothalamic-pituitary-adrenal
  • Binaural beats in the delta (1 to 4 Hz) range have been associated with deep sleep and relaxation. Binaural beats in the theta (4 to 8 Hz) range are linked to REM sleep, reduced anxiety, relaxation, as well as meditative and creative states.
  • One object of the present invention is to provide a device and method that will help users reduce stress levels in their everyday lives .
  • Yet another object of the present invention is to provide a device that will preserve general facial skin health and slow, mitigate the aging process of the and skin
  • Yet another object of the present invention is to provide a system or device that will reduce the cortisol secretion levels in the user's body and thereby help additional physical problems such as male baldness (alopecia process) and obesity by reducing the cortisol secretion levels and thereby, avoid the adverse effects caused by excess secretion of cortisol as detailed above.
  • a device and method for reducing stress levels of the user by utilizing a device which suggests mental and physical activities in real time to reduce cortisol levels, reduce stress levels and thereby optimize skin condition by measuring brain waves and skin condition .
  • the device of the invention can verify the effects of the proposed suggestions to optimize their efficacy.
  • the present invention teaches a system and method that can also be used for additional effects such as reducing the rate of Alopecia process due to stress, and obesity .
  • a user can position the device in accordance to some embodiments of the present invention on one’s head or surrounding the ear for example and operate an application that can preferably be operated on a mobile communication device such as but not limited to smart phone and tablet, to follow suggestions and instructions of the app
  • the present invention includes monitoring, tracking, processing information from a variety of one or more biofeedback sensors such as but not limited to: brain wave monitoring, EEG, heart rate, biofeedback sensors.
  • biofeedback sensors such as but not limited to: brain wave monitoring, EEG, heart rate, biofeedback sensors.
  • the system and method in accordance with some embodiments of the present invention may utilize bioelectrical impedance analysis (BIA) but not limited to, combining the data with other sources of information, analysing and processing the information and comparing said information with external database to conclude the current physical state and provide an actionable activity in real time to send to the user via a network communication device such as a mobile phone, tablet, wearable IOT device or any other communication device known in the art to offer the user in real-time, to lower cortisol levels, reduce mental stress, and thereby maintain the health of the facial skin and maintain the user's general health, all as detailed below:
  • a network communication device such as a mobile phone, tablet, wearable IOT device or any other communication device known in the art to offer the user in real-time, to lower cortisol levels, reduce mental stress, and thereby maintain the health of the facial skin and maintain the user's general health, all as detailed below:
  • a portable, wearable device that monitors the body using bio-feedback sensors, including Bioelectrical impedance analysis, brain waves and skin condition to track physical changes that indicate internal changes which cannot be directly monitored and by using the analysis of the input from the bio-feedback sensors, to deduct mental changes such as stress which causes Cortisol secretion (stress causes the human body to produce cortisol (cortisol is unhealthy for the skin).
  • bio-feedback sensors including Bioelectrical impedance analysis, brain waves and skin condition to track physical changes that indicate internal changes which cannot be directly monitored and by using the analysis of the input from the bio-feedback sensors, to deduct mental changes such as stress which causes Cortisol secretion (stress causes the human body to produce cortisol (cortisol is unhealthy for the skin).
  • the device After reaching the conclusion that cortisol is being released by the body/ stress levels in the user's body are increasing- the device generates push notifications containing an alert informing the user on the current increase of stress levels with actionable mental and physical activities (which are based on different methodologies including Mindfulness and other various stress relief reduction methodologies known in the art) that the user can perform in order for the stress level to be reduced .
  • the suggested activities are personalized per user and may include one or more activities which will be detailed below .
  • system of the invention may verify the effects of the proposed suggestions to optimize their efficacy.
  • This invention aims to optimize the mental state of mind in real-time and ongoing status to prevent degradation of skin due to secretion doses of “bad” hormones such as cortisol .
  • a database resulting from the accumulated data from users can also be used as a global database of dermatology and stress affects and various stress reduction activities.
  • the data resulting from each user can also be used to further learn the personal and specific stressors of the particular user and also to further learn about the efficacy of each mental and physical stress-relieving activity on said user. Due to privacy regulations, the data resulting from using device and method of the present invention can be divided into two kinds of information, such that certain types of information will be kept confidential by being kept on said user's communication device and/ or personal server, while other types of information such as information that do not disclose personal information will be uploaded to the cloud for further analysis and data aggregation and process.
  • the solutions also referred to as the mental and physical activities are based on different methodologies including Mindfulness and other various stress relief reduction methodologies known in the art) that can be suggested and or provided to the user by the present invention can include but are not limited to the following techniques/ solutions:
  • Breathing- using Moderately controlled breathing- Breathing instructions can also be played directly by the device of the present invention whether via the earpiece in an audible manner (for example through speaker 35) or via the mobile phone application.
  • the system 10 can actively suggest to the user to actively call a specific person and upon receiving the approval of the user to call said individual, the system will initiate a telephone call to the user.
  • Games- Natural biofeedback Certain types of calming games can be activated via and or be installed on the system's mobile application 46.
  • Each type of solution can be instructed or delivered to the user directly by the device 20 of the present invention whether via the earpiece in an audible manner or via the mobile phone application 46 by audio, image, or video (including 3D and 4D), etc.
  • Some of the solutions such as music in certain unique frequencies can also be automatically provided by the present invention for example via the associated mobile phone app that can store and or provide said music via the Internet.
  • sensors such as but not limited to camera may be incorporated in a communication device e.g. mobile phone in such a way that would enable the use of the camera to provide additional information for the current state analysis via a designated app or otherwise.
  • Some embodiments of the present invention include real-time alerts by a wearable device to assist users in maintaining their youthful skin condition.
  • the wearable device is wearable on the ear of the user, similar to an earphone or an earpiece.
  • the present invention uses biofeedback measurements to detect changes for example to indicate that the person is experiencing stress and therefore his body produces and releases Cortisol hormone that contributes to the skin aging process. By detecting these changes in real-time and providing actionable activities that reduce the stress levels and reduce the levels of released Cortisol - a desired result is achieved. Facial skin is kept healthier for longer periods of time and the skin aging process is slowed down (assuming the user's cooperation and following by the suggested instructions provided by the system).
  • the device may include EEG sensor, skin sensor, energy source (battery), camera, microphone, Bluetooth (BT) and WIFI, connectivity to Smart devices such as but not limited to smartphone, tablet, smart watches (to measure heartbeat, sweat, temperature) and other IOT devices.
  • the device may also include a bio-impedance sensor 26.
  • the device may also include a skin condition sensor 22.
  • the device 20 can also measure in real-time both the user's brain activity and skin condition and skin conductance, process and deduct the current mental state of the user, report correlation, and suggest actions.
  • the bio feedback sensors can include but are not limited to: Physiological measuring: GSR, skin conductance, optical, chemical, sensor, biosensor, UV, VIS light, Brain activity sensors: EEG, IR, waves alpha, beta, theta, gamma, Functional NIR (FNIR) - measures (oxyhemoglobin concentration), Chemical sensor (chemical sensor is a device designed to detect and measure specific chemical substances in the human body. These sensors are typically used in medical and health-related applications to monitor various physiological parameters and provide real-time data on the body's chemical composition), Camera, Miniature confocal microscope (for high-resolution imaging of biological specimens and other materials at a microscopic scale).
  • the device may also use machine learning methodologies and artificial intelligence (Al) to "learn” each user by Pattern recognition and monitoring, recording, logging body reactions in the short and long term to differentiate its normal stress levels from increased stress levels (optimization & personal learning system).
  • Al artificial intelligence
  • the sensory input from the skin conditions sensor that can be included in device 20 may further include photographs, skin conductance, cortisol concentration etc .
  • the device or system of the invention may receive as an input the measured brain activity, the skin condition, and calculate various correlating features, from which it is possible to deduce on the influence of the brain activity on the skin condition.
  • the device or system of the invention may also store and learn the behaviour (dynamic) of the user and user skin in order to optimize the recommendations for the specific user.
  • the device or system of the invention may also calculate a prediction of the state of the skin according to the behaviour of the user.
  • the device or system of the invention may also receive the associated medical histories for improved diagnostics and use global databases of dermatology information for prediction.
  • global database can be for example Dermanet (for skin diseases), or “Skin Deep” database.
  • Data augmentation techniques, such as image processing can be used to broaden the recognition skills of the system.
  • Types of Brain activity sensors include but are not limited to Electrical (EEG) Brain waves: alpha, theta, gamma, beta, Infrared (FNIR), Oxyhemoglobin, Deoxyhemoglobin, total hemoglobin, Sensor processing.
  • EEG Electrical
  • FNIR Infrared
  • a signal transmission system may reduce extraneous noise and allow for direct connection to an external recording or EEG device .
  • the system may include signal conditioning hardware in the form of a VLSI digital amplifier/signal conditioning unit that can output analogue, digital, or telephonic modulated EEG signals, or an FM telemetry system mounted on the headset for wireless transmission .
  • signal conditioning hardware in the form of a VLSI digital amplifier/signal conditioning unit that can output analogue, digital, or telephonic modulated EEG signals, or an FM telemetry system mounted on the headset for wireless transmission .
  • Skin condition can also be defined by one or more of the following indicators: level of acne vulgaris, Propionibacterium acnes, skin conductance measured by cortisol hormone, pigment measure and skin temperature.
  • the system may further provide the user with questions following a stressful event (meaning a period of time in which the stress levels of the user were elevated and later went down to regular or lower levels) such as but not limited to: who was the with at a certain time, who was the person that caused the stress, what caused the stress levels to rise, where was the user at a specific time period and more.
  • a stressful event meaning a period of time in which the stress levels of the user were elevated and later went down to regular or lower levels
  • Said data can be stored for further analytics that can be later presented to the user for the user's personal use to better said user's understanding of how to avoid certain stressful situations.
  • a device for sensing a user's body parameters, alerting the user when the user's stress level is above a predetermined threshold and providing at least one activity in real time for reducing user's current stress level, thereby reducing cortisol secretion level in said user's body in real time includes one or more bioimpedance sensor, and one or more brain activity sensors.
  • the device further includes a controller for processing and execution of instructions sets. The controller further receives the data collected from the sensors. The data collected from the sensors is processed by the controller. The processed data is analyzed to determine the concentration of stress biomarkers, which can then be correlated with stress levels, thereby, providing to the user his current stress level.
  • Fig 1 shows a block diagram of the system of the invention in accordance with some embodiments of the present invention.
  • Fig 2 shows a flow chart describing a method for detecting stress levels in real-time in accordance with some embodiments of the present invention.
  • FIG. 3 showing a preferred embodiment illustration of the system including the device as a wearable device on the ear of a user.
  • Fig. 4 shows a flow chart describing a method of the invention in accordance with some embodiments of the present invention.
  • Fig 5 shows an exemplary use of a camera in the system.
  • Fig 6 shows an exemplary application page of activity options (also referred to as “solutions”) for reducing stress in accordance with some embodiments of the present invention.
  • Fig 7 shows another application page in accordance with the present invention for illustrating the cerebral calmness level, skin health level and the skin aging prevention level of a user.
  • the innovation relates to a device that will suggest a user real-time recommendations, suggestions and or warnings based on information from sensors that monitor the user's body.
  • the present invention provides a new way to improve the user's physiological and psychological health in a manner such as but not limited to condition of the facial skin, scalp and hair on the user's head, and user's stress level. Following the instructions generated by the device and the method described in the present invention will achieve a significant improvement in the health-related issues.
  • a device 20 in accordance with some embodiments of the present invention for sensing the user body parameters, alerting a user and reducing stress levels of the user in real-time to a normal stress level (or any other predefine threshold) if the user's stress level above normal (or any other predefine threshold).
  • the device may include the following components, a skin conductance sensor 22 also known as a galvanic skin response (GSR) sensor or electrodermal activity (EDA) sensor or any other known skin conductance sensor in the art, is a device that measures the electrical conductance of the skin, which varies with its moisture level. The skin's conductance is influenced by sweat gland activity, which is controlled by the sympathetic nervous system.
  • GSR galvanic skin response
  • EDA electrodermal activity
  • the skin conductance sensor is used for study of the user's stress levels, and other psychological states.
  • the device may further include a chemical sensor that can measure stress levels by detecting specific biomarkers in bodily fluids (such as sweat, saliva, or blood) that are associated with stress. These biomarkers include various hormones and metabolites that are released or change concentration in response to stress. Biomarkers of Stress examples, cortisol: Often referred to as the "stress hormone,” cortisol levels increase in response to stress and can be measured in saliva, blood, or sweat.
  • Adrenaline This hormone is released in response for example to a perceived harmful event, attack, or threat to survival.
  • Another biomarker is Norepinephrine which is similar to adrenaline, it is also part of the body’s stress response and can be detected in blood or saliva.
  • Other Biomarkers can include alpha-amylase, glucose, lactate, and various cytokines and metabolites.
  • the types of chemical sensors can be for example and not limited to Electrochemical Sensors, these sensors use electrodes to detect changes in electrical properties (such as current or voltage) caused by the presence of specific biomarkers.
  • Another type of chemical sensor can be optical Sensors, these sensors use light (absorption, fluorescence, or reflection) to detect changes in the chemical composition of a sample.
  • Yet another type of chemical sensor can be biosensors, these combine a biological component (such as enzymes, antibodies, or receptors) with a physicochemical detector to provide specific and sensitive detection of stress biomarkers.
  • Device 20 may further include bioelectrical impedance sensor 26 which is used to measure the resistance (impedance) of body tissues to the flow of a small, safe electrical current.
  • Device 20 may further include optical bio sensor 28, that uses light to detect biological molecules and analyses biochemical interactions.
  • Device 20 may further include a functional near-infrared spectroscopy (FNIRS) sensor 30 which is a non-invasive device used to measure brain activity by monitoring blood oxygenation levels in the brain.
  • FNIRS sensors utilize near-infrared light to detect changes in blood haemoglobin concentrations, which are associated with neural activity.
  • the FNIRS provides real-time data on brain activity and can be used to explore brain activity related to emotions, decision-making, stress and other cognitive tasks.
  • Device 20 may further include miniature confocal microscope 32 designed to provide high-resolution, three-dimensional imaging of biological tissues.
  • Device 20 may further include brain activity sensors 34 such as but not limited to Electroencephalography (EEG).
  • Device 20 may further include a camera 36. The camera can be utilized for assessing the user's health skin.
  • Device 20 further include a controller 40 and a memory (not shown) for processing and execution of instructions sets that are stored in the memory.
  • the controller further receives the data collected from sensors 22, 24,26, 28, 30, 34. Please note that it is possible to utilize only a subset of these sensors in one or more embodiments of the present invention. This flexibility ensures that the device 20 can be adapted to various contexts and constraints, potentially reducing costs and complexity while maintaining the desired level of functionality.
  • the data collected from said sensors are processed by controller 40.
  • the processed data is analyzed in the controller 40 or remotely through any known suitable communication network in a computing system 44 (such as but not limited to database server and or cloud computing) or by a communication device 46 that has wired or wireless connectivity to the device 20.
  • the processed data can be analyzed for example to determine the concentration of the stress biomarkers, which can then be correlated with stress levels.
  • Device 20 may further include a power supply 42 to power the electrical components in the device 20.
  • the power supply can be connected to the electricity line and/or can be a chargeable standalone power supply.
  • the processor and /or controller 40 can integrate, calculate, and send signals and data to monitor and to analyse signals from the sensors 22, 24,26, 28, 30, 34 and can also be used to deliver the data onwards to the user's communication unit 25 and to external server thereafter in some embodiments of the present invention where the analysis is done not on the device 20 itself but in an external server or cloud computing 44 or in the communication device 46.
  • the calculations and analysis can also be performed by machine learning algorithms and models known in the art.
  • the system can utilize existing or new databases of both brain activity and skin analysis for analysing user's stress level .
  • the invention takes advantage of existing and new databases of both brain and skin analysis.
  • the device 20 may further include a microphone 33 and a speaker 35
  • the calculations, analysis and conclusion process that is based on the overall data from the sensors and external databases 44 can be done either on the device 20, or on the communication device 46, or in the external server or in a cloud 44.
  • step 50 collecting data from one or more of the mentioned sensors 22, 24,26, 28, 30, 32, 34.
  • step 52 processing the collected data from step 50. Processing the data in the context of signal processing for sensors involves several sub-steps to transform the raw signals detected by the sensor into meaningful and useful information.
  • the processing sub-steps that are not shown in step 52 may include preprocessing (noise reduction from raw sensor signal, filtering to isolate the relevant sensor signal components, normalization such as but not limited to scaling (adjusting the amplitude of a signal to a standard range of scale), compensation (correcting for any systematic errors or variations), identification of key features (Extracting relevant features from the signal, such as peaks, amplitudes, frequencies, or other characteristics), pattern recognition (Identifying patterns or trends in the data that correspond to specific conditions), Statistical Analysis (applying statistical methods to interpret the data and assess its significance and reliability), Graphical Representation (creating visual representations of the data, such as graphs, charts, or heatmaps, to facilitate interpretation and decision-making), Real-Time Monitoring (displaying the processed data in real-time for immediate analysis and action), Contextual Analysis and decision Making (using the interpreted data to make informed decisions).
  • preprocessing noise reduction from raw sensor signal, filtering to isolate the relevant sensor signal components, normalization such as but not limited to scaling (adjusting the amplitude of
  • step 54 the collected data can be further processed then, analyse the stress level and the cortisol secretion levels of the user.
  • all the data (for example, the processed data and analysed data of the sensors) can be stored in a database server or cloud.
  • step 56 if the user's stress level is normal, continue monitor user with one or more of the sensors described above and return to step 50.
  • step 56 if the user's stress level is above normal it initiates step 58.
  • step 58 the user is alerted that his stress level is above normal levels.
  • actionable activity suggestion is provided to the user to reduce the user's stress level back to normal and cortisol secretion deduction.
  • step 62 if the user executes the provided actionable activity.
  • step 64 outcome detected from the sensors.
  • step 66 the user is notified about the outcome of performing the activity, for example by presenting the user's real-time stress level.
  • Fig.3 showing preferred embodiment of the device 20 as a wearable device on the ear of a user 70.
  • the device areas in contact with the skin are coated with approved and pleasant-to-touch materials.
  • the exterior of device 20 appearance can be designed as a piece of jewelry, and can be coated with luxurious materials. It fits comfortably on and behind the ear for maximum comfort during continuous daily wear.
  • Device Activation connecting to a communication device 46 such as but not limited to Smartwatch/Smartphone.
  • the device 20 may have concurrent Cloud Connectivity to cloud 44. After activation
  • the device provides continuous/Smart (Periodic) Measurement of Signals received by one or more sensors described in Fig 1
  • the device may include signal Segmentation by Noise Filtering.
  • Fig 3 and Fig.1 showing the wearable device 20, including a processor or controller, Brain activity sensors 34 EEG, IR, waves alpha, beta, theta, gamma, Functional NIR (FNIR) 30 that can measure oxyhaemoglobin concentration, skin conductance sensor 22, bioelectrical impedance sensor 26 and analysis module, energy source (power supply) such as but not limited to battery 42, optical, biosensor, UV, VIS light 28, camera 36, communication unit 25 including but not limited to WIFI and Bluetooth (BT) chemical sensor 24 miniature confocal microscope 32
  • the wearable ear device 20 includes an EEG sensor 34 and skin impedance sensor 26.
  • Each of these sensors includes one or more electrodes 82, 84 that touch the user's skin.
  • the EEG electrodes 82 are essential for example for measuring and recording the electrical activity of the brain.
  • the Electrodes 84 of skin impedance sensor 26 are for example essential for enabling accurate measurement of electrical conductance changes in the skin, which reflect physiological and emotional states.
  • electrodes 82 and 84 are sampling sensory data.
  • the analogue sensed data is digitized and noised filtered.
  • skin impedance data is analysed.
  • EEG signal data and frequency data is analysed.
  • step 98 skin health parameters and cortisol secretion levels are calculated based on analysed data in step 94.
  • cerebral calmness parameters are calculated based on analysed data in step 96.
  • Cerebral calmness parameter(s) referred to changes in brain activity parameters that are associated with stress indicators.
  • step 102 Skin aging Prevention level is calculated based on the aggregated processed data from steps 98 and 100.
  • the term “Aging Preservation” (or “Aging Prevention,” “Aging Delay,” etc.) is used to refer specifically to the prevention of aging rather than the process of reversing or undoing the effects of aging.
  • step 104 user select activity for enhancing calmness.
  • step 106 if there is still a need (i.e.
  • step 108 the user receives indication if the skin aging prevention back to normal (i.e. if the stress levels and Cortisol secretion levels are down).
  • step 110 present skin aging prevention improvement overtime for example on the communication device 46 (designated in Fig 1)
  • the display can be for example by a 3D avatar.
  • step 112 the user can purchase new calmness products /activities.
  • step 114 the user improvement can be shared in a community sharing, public to all or only for a predefined group.
  • user can choose his preferred activities during his first use of the device while setting his preferences and in said cases, after step 102, in case stress levels are above normal levels, the predefined stress reducing activity will automatically start without user intervention.
  • said used can perform one or more of actionable activities (will describe later in more detail) to reduce stress levels, and in which case the outcome of said activity will be detected by the sensors by the continuous monitoring of the sensors which will then transfer said new data to the device, to begin the same data flow process to notify the user of the outcome.
  • Fig. 5 showing a possible use of the possible sensors that exists on communication devices 46 e.g. image of skin area 121 taken from a smartphone camera 123 for helping also to determine the user's stress level.
  • the initial use of the dedicated application of communication device 46 will include using the camera of the communication device 123 to create a 3d avatar of the user to be later used as a template to present a user with digitized embodiments of the result achieved by the use of the system and or a visual representation of the user's facial condition at any given time.
  • the solutions that can be suggested by the present invention to the user can include but are not limited to the following activities that can be displayed by a menu on a dedicated application of the invention on a mobile device 46: Breathing activity 132 using Moderate controlled breathing, meditation, yoga. Music 134 using specific frequencies known for reducing stress levels such as but not limited to: 400 HZ, 432 HZ, 528 HZ, 417 HZ, and 639 HZ. Conversation (friend) 136 talking with another person with a familiar, calming voice. Some of the solutions such as music in certain unique frequencies can also be automatically provided by the present invention for example via the associated mobile phone app that can store and or provide the music via the Internet. Games 138 Natural biofeedback. Odors or scent 140 pheromones, Orange, grass, the odor of a dear person or animal, nutrition 142 no caffeine, ashwagandha root. Physical vibrations massage 144 or mechanical vibrator. Muscle stretching 146 full body muscles stretching.
  • Bar level indicator 152 illustrates for example the user's current cerebral calmness
  • bar level indicator 154 illustrate for example the user's skin health
  • bar level indicator 156 illustrate for example the user's aging prevention (calculated by aggregated the data of the other parameters).
  • the software for the machine learning of the invention can be done with Python interpreter, using Jupiter notebook or any other suitable programming environment.
  • Input- The input to the DLS is one of the proposed measured properties of the skin conditions and the brain activity as was detailed above.
  • the skin condition may include photographs, skin conductance, cortisol concentration etc.
  • the brain activity condition may include electrical wave (EEG), FNIR time series .
  • the program system can receive the associated medical histories for improved diagnostics .
  • the programming of the system 10 can use a global database of dermatology information for prediction.
  • Such global databases can be Dermanet (for skin diseases), or “Skin Deep” Database which provides details on the safety of skincare and cosmetic products.
  • Algorithm (machine & deep learning)- the present invention uses a deep learning system (DLS) to provide a differential diagnosis of skin conditions for daily cases.
  • DLS deep learning system
  • DLS leverages additional data that is available to dermatologists in a tele-dermatology service, such as demographic information DLS distinguishes between common skin conditions, representing. By utilizing the present invention, the DLS may learn more skin profiles and skin health conditions as more people will use the present invention.
  • the DLS was developed and validated using de-identified cases from a internet databases, collaboration from board-certified dermatologists, cosmetologists, practitioners and private databases. Data augmentation techniques, such as image processing was used to broaden recognition skills of the DLS.
  • the DLS can provide a differential modification of the skin.
  • the DLS achieved 0.71 and 0.93 top-1 and top-3 accuracies respectively, indicating the fraction of cases where the DLS’s top diagnosis and top 3 diagnoses contains the correct diagnosis.
  • n 963 cases
  • 18 clinicians reviewed the cases for comparison.
  • the DLS achieved a 0.67 top-1 accuracy, non-inferior to board-certified. Dermatologists (0.63, p ⁇ 0.001 ), and higher than primary care physicians (PCPs, 0.45) and nurse practitioners (NPs, 0.41 ).
  • DLS Deep convolutional neural network
  • CNN convolution neural network
  • SVM supervised vector machine
  • An improvement of the programming system can be performed by assemblies of artificial network, augmentation of the data, image manipulations, modelling, and other known technique in the field.
  • the DLS provides a differential diagnosis across various labelled and unlabelled conditions that include various dermatitis, dermatoses, pigmentary conditions, alopecia, and lesions, to aid clinical decision and health skin.
  • Accessories- Camera can be used to capture areas of interest on the body such as eczema, psoriasis, or drying areas, wrinkles. By using camera, the user can track areas that are inconvenient for sensor.
  • the diagnostic accuracy of general practitioners has been reported to be only 0.24-0.70 (compared to 0.77-0.96 for dermatologists), resulting in over- and under-referrals, delays in care, and errors in diagnosis and treatment.
  • the present invention will provide a desired tool to improve both diagnostic, treatment in early stages of the disease (or deterioration of the skin). It is the only invention (as far as we know) that provide a preventive quantitative tool for skin disorders due to mental state .
  • the present invention takes advantage of global databases for skin and brain waves to improve diagnostics and prognosis (future prediction of skin condition).
  • Database for skin can be (but not only), Dermnet.
  • the database for brain can be (but not only) BrainNet .
  • any reference to the term “comprising” or “having” should be interpreted also as referring to “consisting of’ or “essentially consisting of’.
  • a method that comprises certain steps can include additional steps, can be limited to the certain steps or may include additional steps that do not materially affect the basic the basic and novel characteristics of the method - respectively.
  • any arrangement of components to achieve the same functionality is effectively “associated” such that the desired functionality is achieved.
  • any two components herein combined to achieve a particular functionality may be seen as “associated with” each other such that the desired functionality is achieved, irrespective of architectures or intermedial components.
  • any two components so associated can also be viewed as being “operably connected,” or “operably coupled,” to each other to achieve the desired functionality.

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Abstract

L'invention concerne un dispositif permettant de détecter des paramètres corporels d'un utilisateur, d'alerter l'utilisateur lorsque ledit niveau de stress de l'utilisateur est supérieur à un seuil prédéfini et de fournir au moins une activité permettant de réduire en temps réel le niveau de stress actuel dudit utilisateur, d'où une réduction du niveau de sécrétion de cortisol de l'utilisateur, comprenant un ou plusieurs capteurs de bioimpédance. Le dispositif comprend en outre un ou plusieurs capteurs d'activité cérébrale et un dispositif de commande permettant de traiter et d'exécuter des ensembles d'instructions ; ledit dispositif de commande recevant en outre les données collectées à partir desdits capteurs. Le dispositif de commande traite les données collectées à partir des capteurs. Les données traitées sont analysées pour déterminer la concentration de biomarqueurs de stress, qui peuvent ensuite être corrélés avec des niveaux de stress.
PCT/IL2024/050811 2023-08-14 2024-08-12 Dispositif pouvant être porté sur soi et appareil et procédé permettant de réduire les niveaux de cortisol Pending WO2025037309A1 (fr)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040034289A1 (en) * 2000-06-16 2004-02-19 Eric Teller System for monitoring health, wellness and fitness
EP3081155A1 (fr) * 2006-12-19 2016-10-19 Valencell, Inc. Appareil télémétrique de surveillance de l'environnement et de la santé

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040034289A1 (en) * 2000-06-16 2004-02-19 Eric Teller System for monitoring health, wellness and fitness
EP3081155A1 (fr) * 2006-12-19 2016-10-19 Valencell, Inc. Appareil télémétrique de surveillance de l'environnement et de la santé

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SADICK NEIL S, CALLENDER VALERIE D, KIRCIK LEON H, KOGAN SOPHIA, : "New Insight Into the Pathophysiology of Hair Loss Trigger a Paradigm Shift in the Treatment Approach", J DRUGS DERMATOL 16.11 (2017): S135-S140. SADICK, NEIL S., ET AL. (2017/11/01), J DRUGS DERMATOL 16.11 (2017): S135-S140. SADICK, NEIL S., ET AL. (2017/11/01), 1 November 2017 (2017-11-01), pages 1 - 6, XP093280532, Retrieved from the Internet <URL:https://jddonline.com/articles/new-insight-into-the-pathophysiology-of-hair-loss-trigger-a-paradigm-shift-in-the-treatment-approach-S1545961617S0135X/> *

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