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WO2025019495A3 - Exosomes derived from fermented dairy products - Google Patents

Exosomes derived from fermented dairy products Download PDF

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Publication number
WO2025019495A3
WO2025019495A3 PCT/US2024/038214 US2024038214W WO2025019495A3 WO 2025019495 A3 WO2025019495 A3 WO 2025019495A3 US 2024038214 W US2024038214 W US 2024038214W WO 2025019495 A3 WO2025019495 A3 WO 2025019495A3
Authority
WO
WIPO (PCT)
Prior art keywords
exosomes
dairy products
fermented dairy
exosomes derived
disease sites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/038214
Other languages
French (fr)
Other versions
WO2025019495A9 (en
WO2025019495A2 (en
Inventor
Peixuan Zhu
Javed Siddiqi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exom Biopharma Inc
Original Assignee
Exom Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exom Biopharma Inc filed Critical Exom Biopharma Inc
Publication of WO2025019495A2 publication Critical patent/WO2025019495A2/en
Publication of WO2025019495A3 publication Critical patent/WO2025019495A3/en
Publication of WO2025019495A9 publication Critical patent/WO2025019495A9/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5184—Virus capsids or envelopes enclosing drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are methods and utilities for the isolation of novel exosomes from microorganisms present in yogurt and probiotics. Also provided is a method for these exosomes to encapsulate drugs, nucleic acids, or peptides for delivery to disease sites. These exosomes can also be used directly on disease sites for their intrinsic antifungal and anti inflammatory activity.
PCT/US2024/038214 2023-07-17 2024-07-16 Exosomes derived from fermented dairy products Pending WO2025019495A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363513996P 2023-07-17 2023-07-17
US63/513,996 2023-07-17

Publications (3)

Publication Number Publication Date
WO2025019495A2 WO2025019495A2 (en) 2025-01-23
WO2025019495A3 true WO2025019495A3 (en) 2025-03-20
WO2025019495A9 WO2025019495A9 (en) 2025-04-24

Family

ID=94282550

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/038214 Pending WO2025019495A2 (en) 2023-07-17 2024-07-16 Exosomes derived from fermented dairy products

Country Status (1)

Country Link
WO (1) WO2025019495A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160320273A1 (en) * 2012-04-17 2016-11-03 Life Technologies Corporation Methods and compositions for exosome isolation
US20180193270A1 (en) * 2016-11-29 2018-07-12 PureTech Health LLC Exosomes for delivery of therapeutic agents
KR20230089486A (en) * 2021-12-13 2023-06-20 (주)지에프씨생명과학 A cosmetic composition for skin improvement, containing fermented kefir exosome, which has the effect of improving wrinkles and recovering skin wounds, as an active ingredient.
WO2024153847A1 (en) * 2023-01-17 2024-07-25 Universidad Autónoma de Madrid Procedure for obtaining exosomes from buttermilk, exosomes obtained and their applications

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160320273A1 (en) * 2012-04-17 2016-11-03 Life Technologies Corporation Methods and compositions for exosome isolation
US20180193270A1 (en) * 2016-11-29 2018-07-12 PureTech Health LLC Exosomes for delivery of therapeutic agents
KR20230089486A (en) * 2021-12-13 2023-06-20 (주)지에프씨생명과학 A cosmetic composition for skin improvement, containing fermented kefir exosome, which has the effect of improving wrinkles and recovering skin wounds, as an active ingredient.
WO2024153847A1 (en) * 2023-01-17 2024-07-25 Universidad Autónoma de Madrid Procedure for obtaining exosomes from buttermilk, exosomes obtained and their applications

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
IQBAL ZOYA, REHMAN KHURRUM, MAHMOOD AYESHA, SHABBIR MARYAM, LIANG YUJIE, DUAN LI, ZENG HUI: "Exosome for mRNA delivery: strategies and therapeutic applications", JOURNAL OF NANOBIOTECHNOLOGY, BIOMED CENTRAL, vol. 22, no. 395, 1 July 2024 (2024-07-01), pages 1 - 20, XP093295654, ISSN: 1477-3155, DOI: 10.1186/s12951-024-02634-x *
TSAI SHANG JUI, ATAI NADIA A., CACCIOTTOLO MAFALDA, NICE JUSTIN, SALEHI ARJANG, GUO CHENXU, SEDGWICK ALANNA, KANAGAVELU SARAVANA, : "Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 297, no. 5, 1 November 2021 (2021-11-01), US , pages 101266, XP093082539, ISSN: 0021-9258, DOI: 10.1016/j.jbc.2021.101266 *
YU SIRAN, ZHAO ZHEHAO, SUN LIMING, LI PING: "Fermentation Results in Quantitative Changes in Milk-Derived Exosomes and Different Effects on Cell Growth and Survival", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 6, 15 February 2017 (2017-02-15), US , pages 1220 - 1228, XP055909749, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.6b05002 *
ZHANG QUAN, WANG MIAO, HAN CHUNLE, WEN ZHIJUN, MENG XIAOZHU, QI DONGLI, WANG NA, DU HUANQING, WANG JIANHONG, LU LU, GE XIAOHU: "Intraduodenal Delivery of Exosome-Loaded SARS-CoV-2 RBD mRNA Induces a Neutralizing Antibody Response in Mice", VACCINES, M D P I AG, CH, vol. 11, no. 673, 1 March 2023 (2023-03-01), CH , pages 1 - 12, XP093295661, ISSN: 2076-393X, DOI: 10.3390/vaccines11030673 *

Also Published As

Publication number Publication date
WO2025019495A9 (en) 2025-04-24
WO2025019495A2 (en) 2025-01-23

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