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WO2025018937A1 - Système de moule pour la fabrication de timbres à micro-aiguilles solubles - Google Patents

Système de moule pour la fabrication de timbres à micro-aiguilles solubles Download PDF

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Publication number
WO2025018937A1
WO2025018937A1 PCT/SG2023/050507 SG2023050507W WO2025018937A1 WO 2025018937 A1 WO2025018937 A1 WO 2025018937A1 SG 2023050507 W SG2023050507 W SG 2023050507W WO 2025018937 A1 WO2025018937 A1 WO 2025018937A1
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WO
WIPO (PCT)
Prior art keywords
mask
mould
liquid
hydrophobic
mould system
Prior art date
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Pending
Application number
PCT/SG2023/050507
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English (en)
Inventor
Chee Yen Lim
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Individual
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Individual
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Priority to PCT/SG2023/050507 priority Critical patent/WO2025018937A1/fr
Publication of WO2025018937A1 publication Critical patent/WO2025018937A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/42—Moulds or cores; Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
    • B29C33/424—Moulding surfaces provided with means for marking or patterning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/22—Component parts, details or accessories; Auxiliary operations
    • B29C39/26—Moulds or cores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/22—Component parts, details or accessories; Auxiliary operations
    • B29C39/42—Casting under special conditions, e.g. vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C2033/0094—Means for masking a part of the moulding surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0093—Other properties hydrophobic

Definitions

  • TITLE A MOULD SYSTEM FOR MANUFACTURING DISSOLVABLE
  • the present invention generally relates to a mould system for manufacturing dissolvable microneedle patches. More particularly, the present invention pertains to a mould system for manufacturing microneedle patches, comprising (1) a flat silicone rubber mould comprising a plurality of microneedle cavities on one of its surfaces and (2) a mask that is placed on the silicone rubber mould to define the shape of the dissolvable microneedle patches.
  • microneedle technology has been increasingly applied in the treatment of skin conditions.
  • the decreased likelihood of causing pain, infection, and injury makes microneedles a great platform for self-administration of drugs.
  • drug-loaded dissolving microneedles have received extensive attention in transdermal drug delivery.
  • these dissolvable microneedles do not impose the risk of having foreign material residing in the skin if broken. They can also encapsulate sensitive biomolecules within the needle tips and shafts so that a specific dosage of drugs can be delivered to the skin. They certainly possess a higher drug-loading capacity compared to the coated solid microneedles.
  • Dissolvable microneedle patches are desired to be flexible and large in patch size to treat skin conditions, such as wounds, eczema, depigmentation, etc. which normally involves a large area of the skin.
  • the shape of the dissolvable microneedle patches is also variable, they can be rectangular, squarish, round, crescent or ellipse shape for various parts of the body. Hence, to make these microneedle moulds in various shapes and sizes become challenging and expensive.
  • the volume of the material solution may be 0.05mL to 5mL.
  • a conventional way for containing the material solution is to have a liquid catchment 105 on the silicone rubber mould 100. This liquid catchment 105 is formed by raising the surrounding non-moulding area 115, which has a boundary that defines the shape of the dissolvable microneedle patch.
  • FIG. 2 shows the drying state of the material solution on the silicone rubber mould 100. As the material solution 210 diminishes, some liquid will reside on the wall of the liquid catchment 220 and form a flashing or burr 230 around the perimeter of the silicone rubber mould. An extra cutting step is required to trim the formed dissolvable microneedle patches into shape. This requirement poses another challenge to the manufacturing because the cutting may damage the delicate microneedles.
  • the material solution in the liquid catchment may recede or detach from the wall of the liquid catchment.
  • wetting theory The wetting of a solid surface by a liquid is an outcome of the competition between the surface energy of a solid wall and the surface tension of a liquid. When a solid surface has high surface energy and a liquid has low surface tension, the liquid will wet or adhere to the solid surface. Alternatively, when a solid surface has low surface energy and a liquid has high surface tension, the liquid will not wet the solid surface but tries to minimize its surface area by forming a meniscus or sphere.
  • the water level of the material solution 210 is high, the surface wetting force 320 of the liquid is larger or equal to the surface tension force 340 of the liquid causing the liquid to wet the wall.
  • the higher concentration increases the surface tension force 340. The concentration will continue to rise during the drying state, which makes the surface tension force 340 to rise continuously until a certain stage where it exceeds the surface wetting force 320, causing the liquid to recede or detach from the wall of the liquid catchment 220, as shown in Fig. 3(c).
  • the surface wetting force between the liquid and a solid wall is determined by the surface energy of the solid wall, which is constant throughout the phenomenon. Surface wetting will occur when the solid surface has high enough surface energy to compete with the liquid’ s surface tension.
  • the solid wall of liquid catchment 220 is normally part of the silicone rubber mould, so the wall is slightly hydrophobic or has low surface energy, which contributes to the recession phenomenon.
  • the first technical solution which can be shown in Fig. 4, is to prepare (1) a flat silicone rubber mould 100 having a plurality of microneedle cavities 110 on one of its surfaces and (2) a mask 420 having (a) a mask surface 430 and (b) at least one through hole 440 that has the shape of the dissolvable microneedle patch.
  • the through hole 440 can have any shape such as but not limited to round, square, rectangular, oval, crescent, etc.
  • This mask 420 is placed on the flat silicone rubber mould 100 such that the through hole 440 exposes the microneedle cavities 110 on the flat silicone rubber mould 100.
  • a material solution is dispensed on these through holes 440 so that it covers the through holes 440 and later forms into a dissolvable microneedle patch when dried.
  • the flat silicone rubber mould 100 can be used with any new mask every time a new shape or new size is required, the mould cost is drastically reduced.
  • the conventional liquid catchment 220 will cause the material solution to reside and dry, forming the flashing or burr 230 at the edges of the dissolvable microneedle patches.
  • Our solution which is shown in Fig. 5, involves making mask 420 to be as thin as the dissolvable microneedle patch to eliminate the flashing or burr 230 in Fig. 2.
  • a typical dissolvable microneedle patch may have a thickness ranging from 0.1mm to 0.5mm.
  • the mask surface 430 should be hydrophobic so that the smeared liquid will be pushed back to the through hole 440. This is a critical characteristic because as the thickness of the mask is drastically reduced, the mask 420 will not be able to contain the volume of the material solution, and the material solution will overflow to the mask surface 430. Making the mask surface 430 hydrophobic prohibits such overflow thus can effectively contain the material solution within the through hole 440.
  • the material solution may recede and detach from the boundary of the through hole or liquid catchment during the drying stage, forming incomplete dissolvable microneedle patches.
  • This liquid recession problem is common in the conventional “liquid catchment” approach as well as the “thin mask” approach in the present invention.
  • An effective solution, which is the third technical solution, to this problem of “liquid recession from the boundary of the through hole” is to maintain a high surface energy on the solid wall by having a non-hydrophobic boundary so that the liquid will clinch on to the boundary during the drying stage and form perfect dissolvable microneedle patches.
  • the present invention involves a mould system for manufacturing dissolvable microneedle patches, comprising (1) a flat silicone rubber mould 100 which comprises a plurality of microneedle cavities 110 on one of its surfaces, and (2) a mask 420, which comprises a mask surface 430 and at least a through hole 440 having the shape of the dissolvable microneedle patch, as shown in Fig.
  • the mould system comprises (1) a flat silicone rubber mould 400 which comprises a plurality of microneedle cavities on one of its surfaces, and (2) a mask 420 which is constituted by a top hydrophobic layer 610 and a bottom non-hydrophobic layer 620.
  • the mask 420 is attached to the flat silicone rubber mould 100 through adhering the bottom non-hydrophobic layer 620 the surface comprising microneedle cavities 110.
  • the top hydrophobic layer 610 is made of plastic film between 0.001mm to 0.3mm, which may be further coated with silicone to enhance its hydrophobicity.
  • the material can be PE, PET, APET or other polymers that have the same characteristics.
  • top and bottom non-hydrophobic layer 620 can be a coating of acrylic adhesive between 0.001mm to 0.3mm, and the carrier 630 may be any plastic film with thickness 0.001mm to 0.3mm.
  • This preferred embodiment may be a conventional double-sided adhesive tape.
  • the mould system comprises ( 1 ) a flat silicone rubber mould 400 which comprises a plurality of microneedle cavities on one of its surfaces, and (2) a mask 420 which is constituted by a top hydrophobic layer 610, a top 615 and bottom 620 non-hydrophobic layers, a central carrier 630, which may be hydrophobic, neutral or hydrophilic.
  • the mask 420 is attached to the flat silicone rubber mould 100 through adhering the bottom non-hydrophobic layer 625 to the surface comprising microneedle cavities 110.
  • the hydrophobic layer 610 can be any plastic film with thickness 0.01mm to 0.3mm, which may be further coated with silicone to enhance its hydrophobicity.
  • the material can be PE, PET, APET or other polymers that have the same characteristics.
  • the non-hydrophobic layer 620 can be a coating of acrylic adhesive between 0.001mm to 0.3mm.
  • the second embodiment may be a conventional single adhesive without carrier.
  • Fig. 1 shows a cross section of a prior art’s silicone rubber mould 100, which comprises a liquid catchment 105 by raising the surrounding non-moulding area 115.
  • Fig. 2 shows the drying state of the material solution 210 on the silicone rubber mould 100. As the liquid level goes down, some liquid resides on the wall of liquid catchment 220 which turns into flashing or burr 230 when dried.
  • Fig. 3 shows the surface wetting force 320 and surface tension force 340 of the material solution 210 during the drying stage, (a) when the water volume is high, the surface tension force 340 is smaller or equal to the surface wetting force 320 (wetting prevails); (b) when the water volume reduces due to drying, the surface tension becomes larger than the surface wetting force 320, causing the liquid to recede or detach from the wall of the liquid catchment 220 (surface tension prevails); (c) after recession, the material solution 210 detach form the wall of the liquid catchment 220 and forms incomplete dissolvable microneedle patch.
  • Fig. 4 shows the first technical solution and the first preferred embodiment of the present invention, comprising (1) a flat silicone rubber mould 100 having a plurality of microneedle cavities 110 on one of its surfaces, and (2) a mask 420 comprising a mask surface 430 and at least one through hole 440 having the shape of dissolvable microneedle patch.
  • Fig. 5 shows the second technical solution of the present invention, comprising a thin mask 420, which comprises a hydrophobic mask surface 430 and a through hole 440 having the shape of the dissolvable microneedle patch.
  • Fig. 6 shows the second preferred embodiment of the present invention, comprising (1) a flat silicone rubber mould 100 having a plurality of microneedle cavities 110 on one of its surfaces; and (2) a multi-layered mask 420 having mask surface 430 and at least a through hole 440, the mask 420 is constituted by a top hydrophobic layer 610, and a bottom non-hydrophobic layer 620.
  • Fig. 7 shows the third preferred embodiment of the present invention, comprising (1) a flat silicone rubber mould 100 having a plurality of microneedle cavities 110 on one of its surfaces; and (2) a multi-layered mask 420 having mask surface 430 and at least a through hole 440, the mask 420 is constituted by a top hydrophobic layer 610, a top 615 and a bottom 620 non-hydrophobic layers, and a central carrier 630.
  • Fig. 8 shows the meniscus 800 of the material solution 210 that is formed by using a thin mask with hydrophobic mask surface 430.
  • Fig. 9 shows the manufacturing steps of manufacturing dissolvable microneedle patches using the first preferred embodiment of the present invention.
  • Example 1 Elimination of flashing at the edges of dissolvable microneedle patches
  • the prior art uses the “liquid catchment” approach in which a wall is formed around the microneedle cavities to contain the material solution as it dries up.
  • the liquid catchment area is 10mm 2 and the volume of the material solution is 20pl or 20mm 3 , the depth of the liquid catchment required is at least 2mm.
  • the material solution fills up the liquid catchment, the solution makes contact with the wall and resides on the wall.
  • the material solution evaporates and eventually dries up.
  • the 2mm high liquid residue will dry and turn into flashing or burr around the dissolvable microneedle patch, as shown in Fig. 2.
  • the present invention replaces the “liquid catchment” approach with a “thin mask” approach in which there is no wall for liquid residue and flashing/burr to form.
  • the first preferred embodiment of the present invention involves a mould system comprising ( 1 ) a flat silicone rubber mould 100, which comprises a plurality of microneedle cavities 110 on one of its surfaces; and (2) a mask 420, which comprises a mask surface 430 and at least a through hole 440 having the shape of the dissolvable microneedle patch.
  • Mask 420 can be several millimeter thick or can be made as thin as possible to eliminate the boundary wall of the liquid catchment thus preventing the formation of flashing or burr 230.
  • the thickness of the mask 420 is in the range of 0.01mm to 0.3mm, typically.
  • the thickness of the Mask 420 is made the same as the thickness of the dissolvable microneedle patches where possible, in this way, there is no wall to accumulate any liquid residue and there will not be any flashing or burr.
  • a typical thickness of the dissolvable microneedle patch is between 0.05mm to 0.2mm, beyond which the patch may be too rigid to flex and below which the patch may be too fragile to handle.
  • the mask 420 can be prepared by die-cutting or punching thin materials. Plastic films or composite plastic films, i.e., multi-layered plastic films make good candidates for the mask. In practice, a double-sided adhesive tape will have the required thickness which is also readily applicable to the flat silicone rubber mould.
  • Example 2 Containment of material solution using hydrophobic mask surface
  • the required volume of the material solution for making a dissolvable microneedle patch depends on many factors, including the molecular weight of the material, the concentration and the thickness of the patch, among other factors. Through our experience, a common volume to area rate is 1.0 to 10.0 microliter/mm 2 for certain molecular weight and thickness. As we replace the liquid catchment of the mould with a thin mask, the material solution may overflow out of the boundary of the through holes 440 and flood the mask surface 430. This can be prevented by having a hydrophobic mask surface 430, as explained in the following example shown in Fig. 8.
  • the mask 420 may be 0.1mm thick and its through hole area is 10mm 2 ; the volume of the material solution is 20pl or 20mm 3 . So, after fully covering the through hole’s area of 10 mm 2 , the water level is 2mm high. This 2mm high water level would require at least a liquid catchment of 2mm high for containing the liquid within the through hole 440, with a mask’s thickness of 0.1mm, the liquid might overflow out of the through hole 440, as shown in Fig. 8(a).
  • the wetting of a solid surface by a liquid is an outcome of the competition between the surface energy of a solid wall and the surface tension of a liquid.
  • the liquid When a solid surface has high surface energy and a liquid has low surface tension, the liquid will wet or adhere to the solid surface.
  • the liquid when a solid surface has low surface energy and a liquid has high surface tension, the liquid will not wet the solid surface but tries to minimize its surface area (normally forming a meniscus or sphere).
  • the second preferred embodiment of the present invention involves a mould system comprising (1) a flat silicone rubber mould 100 having a plurality of microneedle cavities on one of its surfaces, and (2) a mask 420 having a mask surface 430 which is hydrophobic and having at least a through hole 440 having the shape of the dissolvable microneedle patches.
  • Mask 420 is made as thin as possible to eliminate the boundary wall of the liquid catchment thus preventing the formation of flashing or burr 230.
  • the thickness of the mask 420 is in the range of 0.01mm to 0.3mm, typically.
  • the thickness of the Mask 420 is made to have the same the thickness as of the dissolvable microneedle patches where possible, in this way, there is no wall to accumulate any liquid residue and there will not be any flashing or burr.
  • a typical thickness of the dissolvable microneedle patch is between 0.05mm to 0.2mm, beyond which the patch may be too rigid to flex and below which the patch may be too fragile to handle.
  • the mask 420 can be prepared by die-cutting or punching thin hydrophobic materials. Plastic films or composite plastic films, i.e., multi-layered plastic films are naturally hydrophobic, which make good candidates for the mask.
  • double-sided or single-sided adhesive tapes have the required thickness which is also readily applicable to the flat silicone rubber mould.
  • Other common ways to make a surface hydrophobic include coating the surface with a layer of hydrophobic material, e.g. silicone, and surface treatment such as plasma treatment to change the surface’s property to become hydrophobic.
  • the wetting of a solid surface by a liquid is an outcome of the competition between the surface energy of a solid wall and the surface tension of a liquid.
  • the liquid When a solid surface has high surface energy and a liquid has low surface tension, the liquid will wet or adhere to the solid surface.
  • the liquid Inversely, when a solid surface has low surface energy and a liquid has high surface tension, the liquid will not wet the solid surface but tries to minimize its surface area by forming a meniscus or sphere.
  • the liquid catchment on the conventional silicone rubber mould in Fig. 3(a) has low surface energy, so the adhesion of the material solution to the wall of the liquid catchment is not strong and the material solution is loosely adhered to the wall.
  • the material solution will dry up and volume reduction will cause its concentration to rise, thereby increasing its surface tension. As soon as the concentration of the material solution rises to a threshold, causing the surface tension of the material solution to exceed the surface energy of the solid wall, the material solution may recede or detach from the solid wall and form an irregular meniscus, as shown in Fig. 3(c).
  • the solid wall non-hydrophobic or use a material with high surface energy This is achieved by having a multi-layered mask.
  • the first and the second preferred embodiments will not work because a hydrophobic mask, either by material’s natural surface property or by surface treatments, will have the boundary of the through hole also hydrophobic, making the mask prone to liquid recession/detachment problem.
  • Fig. 6 shows the third preferred embodiment of the present invention, comprising (1) a flat silicone rubber mould 100 having a plurality of microneedle cavities 110 on one of its surfaces; and (2) a multi-layered mask 420 having mask surface 430 and at least a through hole 440, the mask 420 is multi-layered and is constituted by a top hydrophobic layer 610, and a bottom non-hydrophobic layer 620, wherein the bottom non-hydrophobic layer 620 is attached to the flat silicone rubber mould 100 via one of its surfaces that comprises a plurality of microneedle cavities 110.
  • Fig. 7 shows the fourth preferred embodiment of the present invention, comprising (1) a flat silicone rubber mould 100 having a plurality of microneedle cavities 110 on one of its surfaces; and (2) a multi-layered mask 420 having mask surface 430 and at least a through hole 440, the mask 420 is multi-layered and is constituted by a top hydrophobic layer 610, a top 615 and a bottom 620 non-hydrophobic layers, and a central carrier 630 which is sandwiched between the top and bottom non-hydrophobic layers, wherein the bottom non-hydrophobic layer 620 is attached to the flat silicone rubber mould 100 via one of its surfaces that comprises a plurality of microneedle cavities 110.
  • the mask 420 in Fig. 6 can be made with a non-carrier adhesive tape with top and bottom protective films and the mask 420 in Fig. 7 can be made with a double-sided adhesive tape with top and bottom protective films.
  • the protective films are made of plastics such as PET, APET, PVC etc. which are hydrophobic or have low surface energy, which make a good mask surface. These protective films can undergo surface treatments to enhance their hydrophobicity.
  • the non-hydrophobic layers in Figs. 6 and 7 can be made of a layer of acrylic adhesive.
  • a mould system from the second preferred embodiment will be used to manufacture dissolvable microneedles.
  • Other preferred embodiments are used in the same way.
  • the manufacturing steps are in the following paragraphs and also shown in Fig. 9.
  • a mould system 900 of the second preferred embodiment is provided.
  • the mould system 900 is put in a vacuum chamber and subjected to vacuum pressure for a length of time, for example but not limited to -0.7bar to -Ibar and 1 to 60 minutes respectively. After the vacuum treatment (this step is not shown in the figure), the mould system 900 is removed from the vacuum chamber and placed under atmospheric pressure (Step 1).
  • a material solution 210 which is separately prepared, is dispensed on the mould under atmospheric pressure as soon as the mould system 900 is taken out of the vacuum chamber.
  • the material solution 210 is dispensed within the through hole 440 (Step 2), which is also on the microneedle cavities 110 of the flat silicone rubber mould 100.
  • the material solution 210 is spread out to cover the entire through hole 440 by pushing the liquid beyond the boundary of the through hole 440, as shown in Fig. 9 (Step 3).
  • the material solution 210 has a prevailing surface tension force which tends to minimize its surface area by pulling back the liquid (Step 4) (instead of spreading out) and forming a meniscus 800 around the boundary of the through hole 440 (Step 5).
  • the meniscus 800 is dried in room temperature which forms a dissolvable microneedle patch 1000 without flashing or burr (Step 6).

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Abstract

La présente invention concerne un système de moule pour fabriquer des timbres à micro-aiguilles solubles, comprenant (1) un moule en caoutchouc de silicone plat 100 qui comprend une pluralité de cavités à micro-aiguilles 110 sur l'une de ses surfaces, et (2) un masque 420, qui comprend une surface de masque 430 et au moins un trou traversant 440 ayant la forme du timbre à micro-aiguilles soluble, tel que représenté sur la figure 4.
PCT/SG2023/050507 2023-07-19 2023-07-19 Système de moule pour la fabrication de timbres à micro-aiguilles solubles Pending WO2025018937A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/SG2023/050507 WO2025018937A1 (fr) 2023-07-19 2023-07-19 Système de moule pour la fabrication de timbres à micro-aiguilles solubles

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Application Number Priority Date Filing Date Title
PCT/SG2023/050507 WO2025018937A1 (fr) 2023-07-19 2023-07-19 Système de moule pour la fabrication de timbres à micro-aiguilles solubles

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US20210016071A1 (en) * 2014-04-24 2021-01-21 Georgia Tech Research Corporation Microneedles and Methods of Manufacture Thereof
KR20220052864A (ko) * 2020-10-21 2022-04-28 인제대학교 산학협력단 마이크로 니들 제작을 위한 몰드 및 이의 제조방법

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