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WO2025017554A1 - Compositions de concentré en suspension de spinosynes - Google Patents

Compositions de concentré en suspension de spinosynes Download PDF

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Publication number
WO2025017554A1
WO2025017554A1 PCT/IL2024/050700 IL2024050700W WO2025017554A1 WO 2025017554 A1 WO2025017554 A1 WO 2025017554A1 IL 2024050700 W IL2024050700 W IL 2024050700W WO 2025017554 A1 WO2025017554 A1 WO 2025017554A1
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Prior art keywords
spp
suspension concentrate
spinosad
weight
composition
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Inventor
Yaakov MINES
Yohai Dayagi
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Adama Makhteshim Ltd
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Adama Makhteshim Ltd
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Publication of WO2025017554A1 publication Critical patent/WO2025017554A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A01P7/04—Insecticides

Definitions

  • the present invention relates to novel suspension concentrate (SC) compositions comprising a spinosyn insecticide, at least one dispersing agent and particular additive.
  • SC compositions of the invention are stable and useful in controlling animal pests.
  • spinosyn insecticides have gained considerable attention due to their unique properties and commercial value.
  • Spinosyns are naturally derived compounds produced from fermentation of the bacterium Saccharopolyspora spinosa, and their unique mechanism of action involves disruption of nicotinic acetylcholine receptors.
  • the spinosyns When compared with many other insecticides, the spinosyns generally show greater selectivity toward target insects and minor activity against many beneficial predators as well as mammals and other aquatic and avian animals.
  • spinosyn insecticides can be attributed to their superior efficacy, broad spectrum of activity, and favorable safety profile. They have found extensive use in various agricultural settings, including field crops, vegetables, fruits, and ornamentals.
  • Spinosad is a combination of the two principal fermentation factors, spinosyns A and D. Structure-activity relationships have been extensively studied, leading to development of a semisynthetic second-generation derivative, spinetoram.
  • spinosyn-based formulations promotes safer and more environmentally friendly pest control solutions offering effective pest management strategies while minimizing the potential risks associated with conventional chemical pesticides and will help farmers address pest resistance issues that arise from prolonged use of traditional synthetic chemicals.
  • SC Suspension concentrate
  • rheology modifiers are added by formulators as must-have components to provide compositions with increased viscosity therefore preventing sedimentation of the solid active ingredient.
  • rheology modifiers examples include Xanthan gum (polysaccharide), Veegum® (magnesium aluminum silicate) hydrophilic silica, smectite, bentonite clay, cellulose and cellulose derivatives such as carboxymethyl cellulose.
  • insecticidal suspension concentrate (SC) compositions comprising a spinosyn insecticide, at least one dispersing agent and particular additive, more specifically, poly alkoxylated alkyl ethers wherein the alkyl group contains from about 1 carbon atom to about 10 carbon atoms can be formulated without the incorporation of rheology modifier and still provide a stable uniformly dispersed SC composition.
  • SC suspension concentrate
  • SC compositions comprising the spinosyn insecticide spinosad, a dispersant selected from Tersperse 2020 (Indorama) and Atlox 4913 (Croda) and the poly alkoxylated alkyl ether Atlas G5002 LQ (Croda) upon dilution with water, dispersed evenly and uniformly.
  • the present invention thus relates to an insecticidal suspension concentrate composition
  • an insecticidal suspension concentrate composition comprising a) a spinosyn insecticide; b) at least one dispersing agent and c) poly alkoxylated alkyl ether wherein the alkyl group contains from about 1 carbon atom to about 10 carbon atoms.
  • the present invention relates to methods for using an SC insecticidal composition as defined above.
  • a method of controlling animal pests comprising applying to a locus, such as a field of crop, an effective amount of such SC composition.
  • the present invention relates to the disclosed compositions which are diluted and ready for use and which comprises from about 0.001% to about 2% by weight said spinosyn insecticide; from about 0.0001% to about 0.5% by weight of a dispersant; and from about 0.00001% to about 0.5% by weight said poly alkoxylated alkyl ether.
  • the term "effective amount” refers to an amount of the active component that is commercially recommended for use to control and/or prevent pest.
  • the commercially recommended amount for each active component often specified as application rates of the commercial formulation, may be found on the label accompanying the commercial formulation.
  • the commercially recommended application rates of the commercial formulation may vary depending on factors such as the plant species and the pest to be controlled.
  • the term "pest” includes, but is not limited to, unwanted phytopathogenic harmful fungi, unwanted insect, unwanted nematode, and weed.
  • the term "pesticide” broadly refers to an agent that can be used to prevent, control and/or kill a pest.
  • the term is understood to include but is not limited to fungicides, insecticides, nematicides, herbicides, acaricides, parasiticides or other control agents.
  • fungicides insecticides, nematicides, herbicides, acaricides, parasiticides or other control agents.
  • specific compounds of each class see "The Pesticide Manual Thirteenth Edition” (British Crop Protection Council, Hampshire, UK, 2003), as well as “The e-Pesticide Manual, Version 3" (British Crop Protection Council, Hampshire, UK, 2003-04), the contents of each of which are incorporated herein by reference in their entirety.
  • locus includes not only areas where the pest may already be developed, but also areas where pests have yet to emerge, and also to areas under cultivation. Locus includes the plant or crop and propagation material of the plant or crop. Locus also includes the area surrounding the plant or crop and the growing media of the plant or crop, such as soil and crop field.
  • ha refers to hectare
  • agriculturally acceptable carrier means carriers which are known and accepted in the art for the formation of compositions/formulations for agricultural or horticultural use.
  • composition or “formulation” can be applied, for example, in a single “ready-mix” form, in a combined spray mixture composed from separate formulations of the single active ingredient components, such as a "tank-mix”.
  • the present invention relates to an insecticidal suspension concentrate composition
  • an insecticidal suspension concentrate composition comprising a) a spinosyn insecticide; b) at least one dispersing agent and c) poly alkoxylated alkyl ether wherein the alkyl group contains from about 1 carbon atom to about 10 carbon atoms.
  • SC Suspension concentrate
  • rheology modifiers are added by formulators as must-have components to provide compositions with increased viscosity therefore preventing sedimentation of the solid active ingredient. Examples of commonly used rheology modifiers are Xanthan gum (polysaccharide), Veegum® (magnesium aluminum silicate) etc.
  • agrochemical suspension concentrate compositions of the present invention can be formulated without the incorporation of rheology modifier and still provide a stable uniformly dispersed SC composition.
  • the dispersing agent is selected from vinyl pyrrolidone polymers, dioctyl sulfosuccinates, poly acrylic graft copolymers, sodium lignosulphonates, alkyl naphthalene sulfonate-formaldehyde condensates, alkylarylsulfonic acids and their salts, tristyrylphenol alkoxylates, tristyrylphenol ethoxylates phosphate and their salts, tristyrylphenol ethoxylates sulphate and their salts, distyrylphenol ethoxylates sulphate and their salts, polycarboxylates, vegetable oil ethoxylates and any combination thereof.
  • the dispersing agent is selected from poly acrylic graft copolymers, (alkyl) naphthalene sulfonate-formaldehyde condensates and any combination thereof.
  • the vinyl pyrrolidone polymer is selected from polyvinylpyrrolidones, alkylated vinylpyrrolidone polymers vinylpyrrolidone copolymers and any combination thereof.
  • the vinylpyrrolidone copolymer is vinylpyrrolidone/vinyl acetate copolymer.
  • Non-limiting examples of polyvinylpyrrolidones include AgrimerTM 15, AgrimerTM 30, AgrimerTM 60L, AgrimerTM 90 and AgrimerTM 120.
  • Non limiting examples of vinyl pyrrolidone/vinyl acetate copolymers include AgrimerTM VA 3E, AgrimerTM VA 5E, AgrimerTM VA 6E, AgrimerTM VA 7E, AgrimerTM VA 31, AgrimerTM VA 51, AgrimerTM VA 71, AgrimerTM VA 7W and AgrimerTM VA 6.
  • the poly acrylic graft copolymer comprises with monomers of acrylic acid their esters and salts.
  • the poly acrylic graft copolymers are selected from (meth)acrylate grafted with polyalkyloxide chains, alkyl(meth)acrylate grafted with polyalkyloxide chains and any combination thereof.
  • the alkyl of said alkyl(meth)acrylate grafted with polyalkyloxide chains is selected from the group consisting of methyl, ethyl, propyl, and any combination thereof (e.g., AtloxTM 4913 and Agrilan® 755).
  • the poly acrylic graft copolymers are selected from hydrophobically modified poly acrylates such as Agrilan® 788 and Agrilan® 789.
  • Non limiting example of sodium lignosulphonates include Vanisperse CBTM.
  • Non limiting examples of (alkyl) naphthalene sulfonate-formaldehyde condensates include Tersperse® 2020, Morwet D-425®, Morwet D-809® and Supragil® MNS 88/E.
  • Non limiting examples of tristyrylphenol alkoxylates include Soprophor® BSU, Soprophor® CY/8, Soprophor® S/25, Soprophor® TS/54 and Soprophor® TSP/724.
  • Non limiting examples of tristyrylphenol ethoxylates phosphate and their salts include Soprophor® FL, Soprophor® FL/6O, Soprophor® FLK and Soprophor® 3D33.
  • Non limiting examples of tristyrylphenol ethoxylates sulphate and their salts include Soprophor® 4D384 and Tersperse® 2218.
  • Non limiting examples of distyrylphenol ethoxylates sulphate and their salts include Soprophor® DSS/7.
  • the poly alkoxylated alkyl ether is butyl ether of polyoxyethylene/polyoxypropylene block copolymer.
  • Non limiting examples of butyl ether of polyoxyethylene/polyoxypropylene block copolymer include Ethylan® NS 500 and AtlasTM G5002 LQ, Antarox® B/848 and Synergen 848.
  • the dispersing agent is methyl(meth)acrylate grafted with polyalkyloxide chains, (alkyl) naphthalene sulfonate-formaldehyde condensates and any combination thereof and the poly alkoxylated alkyl ether is a butyl ether of polyoxyethylene/polyoxypropylene block copolymer.
  • the amount of the dispersing agent comprised within the SC composition of the invention is from about 0.5% to about 20%, from about 0.5% to about 15%, from about 0.5% to about 10%, from about 2% to about 8%, or from about 3% to about 7%, by weight; and/or the amount of said poly alkoxylated alkyl ether comprised within the SC composition of the invention is from about 0.1% to about 15%, from about 0.1% to about 10%, from about 0.1% to about 5%, or from about 0.5% to about 3% by weight.
  • the amount of the dispersing agent comprised within the SC composition of the invention is from about 1% to about 6% by weight; and/or the amount of said poly alkoxylated alkyl ether comprised within the SC composition of the invention is from about 0.5% to about 3% by weight.
  • the amount of the dispersing agent comprised within the SC composition of the invention is of about 6% by weight; and/or the amount of said poly alkoxylated alkyl ether comprised within the SC composition of the invention is of about 1% by weight.
  • each one of the dispersing agents and said poly alkoxylated alkyl ether mentioned throughout this specification includes any commercially available product comprising or consisting essentially of a particular such dispersant or surfactant.
  • consisting essentially of as used herein with respect to said commercially available product means that said product comprises at least 80%, but preferably at least about 85%, 88%, 90%, 92%, 94%, 96%, 98%, or 99%, by weight, of said particular dispersing agent or said poly alkoxylated alkyl ether, such that any other material if included within said product does not affect the basic physical and chemical properties of said dispersing agent or poly alkoxylated alkyl ether.
  • the spinosyn insecticide is selected from spinosad and spinetoram.
  • the amount of the spinosyn insecticide comprised within the SC composition of the invention is from about 1% to about 60%, from about 10% to about 55%, from about 15% to about 50%, or from about 20% to about 48%, by weight.
  • the spinosyn insecticide is spinosad.
  • the suspension concentrate comprises from about 1% to about 60% by weight said spinosyn insecticide; from about 0.5% to about 20% by weight of a dispersant; and from about 0.1% to about 15% by weight said poly alkoxylated alkyl ether.
  • said spinosyn insecticide is spinosad; b) said dispersant is selected from alkyl naphthalene sulfonate-formaldehyde condensates, methyl(meth)acrylate grafted with polyalkyloxide chains and any combination thereof, and c) said poly alkoxylated alkyl ether is polyoxyethylene/polyoxypropylene butyl ether block copolymer.
  • SC composition further comprising an organo-silicone based surfactant.
  • the organo-silicone based surfactants are selected from polyalkyleneoxide modified heptamethyltrisiloxane.
  • Non limiting examples of polyalkyleneoxide modified heptamethyltrisiloxane include Break- thru® S233, Break-thru® S240, Silwet® L77 and Silwet® 806.
  • the suspension concentrate further comprises at least one agriculturally acceptable additive.
  • the at least one additive is selected from carriers, anti-foaming agents, wetting agents, anti-freeze agents, stabilizers, preservatives, antioxidants, thickeners, emulsifiers, spreading agents, dyes and penetrates.
  • the carrier is water.
  • the suspension concentrate according to the invention comprises a spinosyn insecticide
  • a dispersant is selected from alkyl naphthalene sulfonate-formaldehyde condensates, methyl(meth)acrylate grafted with polyalkyloxide chains and any combination thereof, polyoxyethylene/polyoxypropylene butyl ether block copolymer and water.
  • the suspension concentrate according to the invention comprises spinosad
  • a dispersant is selected from alkyl naphthalene sulfonate-formaldehyde condensates, methyl(meth)acrylate grafted with polyalkyloxide chains and any combination thereof, polyoxyethylene/polyoxypropylene butyl ether block copolymer and water.
  • compositions of the invention are antifoams, adjuvants, preservatives, antioxidants, dyes and inert fillers.
  • Suitable antifoams are all substances which can typically be used for this purpose in agrochemicals. Preference is given to silicone oils, silicone oil formulations, magnesium stearate, phosphinic acids and phosphonic acids. Examples are BreakThru® AF9902 or BreakThru® AF9902 from Evonik Industries AG, Silcolapse® 482 from Bluestar Silicones, Silfoam® SCI 132 from Wacker [dimethylsiloxanes and -silicones, CAS No. 63148-62-9], SAG 1538 or SAG 1572 from Momentive [dimethylsiloxanes and -silicones, CAS-Nr. 63148-62-9] or Fluowet® PL 80.
  • Suitable antioxidants are all substances which can typically be used for this purpose in agrochemicals. Preference is given to butyl hydroxytoluene [3,5-di-tert-butyl-4- hydroxytoluene, CAS No. 128-37-0],
  • the viscosity of the suspension concentrate is less than 3000 cP, less than 1700 cP, less than 1500 cP, less than 1000 cP, less than 500 cP, or less than 300 cP.
  • the viscosity of the suspension concentrate is between about 50 cP to about 3000 cP, about 50 cP to about 2000 cP, about 50 cP to about 1700 cP, about 50 cP to about 1000 cP, or about 50 cP to about 300 cP.
  • compositions according to the invention comprises:
  • the suspension concentrate compositions of the invention comprises spinosad, a dispersant selected from alkyl naphthalene sulfonate-formaldehyde condensates, methyl(meth)acrylate grafted with polyalkyloxide chains and any combination thereof, polyoxyethylene/polyoxypropylene butyl ether block copolymer and water without the incorporation of a rheology modifier.
  • a dispersant selected from alkyl naphthalene sulfonate-formaldehyde condensates, methyl(meth)acrylate grafted with polyalkyloxide chains and any combination thereof, polyoxyethylene/polyoxypropylene butyl ether block copolymer and water without the incorporation of a rheology modifier.
  • the present invention relates to various agricultural uses and methods for controlling animal pests, in which the suspension concentrate composition as defined in any one of the embodiments above is utilized.
  • a method for controlling animal pests comprising applying an effective amount of the suspension concentrate composition to a locus where the animal pest is to be controlled and/or prevented so as to thereby control and/or prevent the animal pest.
  • the locus is a crop field.
  • crops include pomaceous fruit, stone fruit, soft fruit, apples, pears, avocado, plums, peaches, almonds, cherries, berries, strawberries, raspberries, blackberries, citrus fruit, oranges, lemons, grapefruit, tangerines, cucurbits, pumpkins, cucumbers, melons, lettuce, cabbages, carrots, tomatoes, potatoes, peppers, chilli, okra, eggplants, beans, peas, soya, oilseed rape, olives, sunflowers, ground nuts, cotton, nuts, coffee, grapevines, ornamentals, and lauraceae.
  • pome fruits including: crabapples, mayhaw pears, quince; asparagus, banana, plantain, bulb vegetables including: dry bulb onion, garlic, great headed (elephant) garlic, green onion, leek, shallot, welch onion; bushberries including, blueberry, currant, elderberry, gooseberry, huckleberry, juneberry, lingonberry, salal, caneberries including: blackberry, black raspberry, loganberry, red raspberry and cultivars and/or hybrids of these citrus trees including: grapefruit, lemons, limes, oranges, tangerines; cole crops (Brassica vegetables) including: broccoli; broccoli raab, brussels sprouts, cabbage, cauliflower, cavalo, Chinese broccoli, Chinese cabbage (bok choy), Chinese cabbage (napa), Chinese mustard cabbage (gai choy), collards, kale, kohlrabi, mizuna, mustard greens, mustard spinach, rape greens, cucurbits including: cucumber,
  • Animal pests that can be controlled by the method of the present invention are selected from the order of Lepidoptera, Diptera, Hemiptera, Thysanoptera, Coleoptera, Hymenoptera Heteroptera, Homoptera, Thysanoptera, acarine, nematode and mollusc.
  • the compositions of the invention can be used to combat and control infestations of animal pests such as Lepidoptera, Diptera, Hemiptera, Thysanoptera, Coleoptera, Hymenoptera and also other invertebrate pests, for example, acarine, nematode and mollusc pests.
  • insects Insects, acarines, nematodes and molluscs are hereinafter collectively referred to as pests.
  • the animal pests which may be combated and controlled by the use of the invention compounds include those animal pests associated with agriculture (which term includes the growing of crops for food and fibre products), horticulture and animal husbandry, forestry and the storage of products of vegetable origin (such as fruit, grain and timber).
  • Non limiting examples of pest species which may be controlled by the compositions of the invention include Myzus persicae (aphid), Aphis gossypii (aphid), Aphis fabae (aphid), Lygus spp. (capsids), Dysdercus spp.
  • Acarina for example, Acarus siro, Aceria sheldoni, Aculus pointedendali, Amblyomma spp., Argas spp., Boophi- lus spp., Brevipalpus spp., Bryobia praetiosa, Calipitrimerus spp., Chorioptes spp., Derma- nyssus gallinae, Eotetranychus carpini, Eriophyes spp., Hyalomma spp., Ixodes spp., Oly- gonychus pratensis, Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Tarsonemus
  • Tetranychus spp. From the order Coleoptera, for example, Agriotes spp., Anthonomus spp., Atomaria linearis, Chaetocnema tibialis, Cosmopolites spp., Curculio spp., Dermestes spp., Diabrotica spp., Epilachna spp., Eremnus spp., Lepti- notarsa decemLineata, Lissorhoptrus spp., Melolontha spp., Orycaephilus spp., Otiorhyn- chus spp., Phlyctinus spp., Popillia spp., Psylliodes spp., Rhizopertha spp., Scarabeidae, Sitophilus spp., Sitotroga spp., Tenebrio spp., Tribolium s
  • Triatoma spp. From the order Homoptera, for example Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella spp., Aphididae, Aphis spp., Aspi- diotus spp., Bemisia tabaci, Ceroplaster spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Coccus hesperidum, Empoasca spp., Eriosoma larigerum, Erythroneura spp., Gascardia spp., Laodelphax spp., Lecanium corni, Lepidosaphes spp., Macrosiphus spp., Myzus spp., Nephotettix spp., Nilaparvata spp., Parlatoria spp., Pemphigus spp., Pianococc
  • Vespa spp. From the order Lepidoptera, for example, Acleris spp., Adoxophyes spp., Aegeria spp., Agrotis spp., Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyrotaenia spp., Autographa spp., Busseola fusca, Cadra cautella, Carposina nipponensis, ChNo spp., Choristoneura spp., Clysia ambi- guella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp., Crocidolomia binotalis, Cryptophlebia leucotreta, Cydia spp., Diatraea spp., Diparopsis castanea, Earias spp.
  • animal pests that can be controlled by the method of the present invention are selected from Codling moth, European grapevine moth, Leafminers, Leafrollers, Light brown apple moth, Oriental fruit moth, Thrips such as: Chilli, Cuban laurel, western flower; Tufted apple budmoth, Asparagus beetles, Armyworms, Dipteran leafminers, European corn borer, Flea beetle, Loopers, Fireworms, Fruitworms, Moth, Sawfly, Katydids, Worms (caterpillars), Cankerworm, Cabbage Looper, Diamondback Moth, Imported cabbage worm, Worms (caterpillars), Carob moth, borers, moth, fruit flies, Colorado potato beetle, worms (berry moth), cutworms, naval orangeworm, peach twig borer, artichoke plume moth, corn borers, Japanese beetle, Earworm, filbert worm, hus
  • the suspension concentrate composition according to the present invention is applied in an amount from about 9.6 g/ha of spinosad to about 480 g/ha of a spinosyn insecticide.
  • the suspension concentrate composition according to the present invention is applied in an amount from about 9.6 g/ha of spinosad to about 480 g/ha of spinosad.
  • composition or “formulation” of the present invention can be diluted in water prior to the use in the field.
  • composition according to the invention is diluted and ready for use.
  • the diluted ready to use compositions comprises from about 0.001% to about 2% by weight of a spinosyn insecticide; from about 0.0001% to about 0.5% by weight of a dispersant; and from about 0.00001% to about 0.5% by weight said poly alkoxylated alkyl ether.
  • the diluted ready to use compositions comprises from about 0.1% to about 0.7% by weight of a spinosyn insecticide; from about 0.001% to about 0.1% by weight of a dispersant; and from about 0.0001% to about 0.1% by weight said poly alkoxylated alkyl ether.
  • the diluted ready to use compositions comprises from about 0.01% to about 2% by weight said spinosyn insecticide; from about 0.0005% to about 0.05% by weight of a dispersant; and from about 0.0001% to about 0.05% by weight said poly alkoxylated alkyl ether. In some embodiments, the diluted ready to use compositions comprises from about 0.1% to about 0.7% by weight of a spinosyn insecticide; from about 0.002% to about 0.08% by weight of a dispersant; and from about 0.0003% to about 0.02% by weight said poly alkoxylated alkyl ether.
  • the diluted ready to use compositions comprises from about 0.2% to about 0.5% by weight of a spinosyn insecticide; from about 0.002% to about 0.08% by weight of a dispersant; and from about 0.0003% to about 0.02% by weight said poly alkoxylated alkyl ether.
  • the dilution of a certain amount of the concentrate in an amount of aqueous medium e.g., water yields a stable liquid dilution composition having a desired clarity and good efficacy.
  • the dilution of the concentrate in an aqueous medium may be of about 1:100,000, about 1:80,000, about 1:50,000, about 1:10,000, about 1:5000, about 1:1000, about 1:200, about 1:100, about 1:50 or, about 1:10.
  • the diluted and ready to use composition disclosed herein is for controlling animal pests comprising applying an effective amount of the suspension concentrate composition to a locus where the animal pest is to be controlled and/or prevented so as to thereby control and/or prevent the animal pest.
  • the locus is home gardens, lawns and ornamentals.
  • Non limiting examples are pome fruits including: crabapples, mayhaw pears, quince; asparagus, banana, plantain, bulb vegetables including: dry bulb onion, garlic, great headed (elephant) garlic, green onion, leek, shallot, welch onion; bushberries including, blueberry, currant, elderberry, gooseberry, huckleberry, juneberry, lingonberry, salal, caneberries including: blackberry, black raspberry, loganberry, red raspberry and cultivars and/or hybrids of these citrus trees including: grapefruit, lemons, limes, oranges, tangerines; cole crops (Brassica vegetables) including: broccoli; broccoli raab, brussels sprouts, cabbage, cauliflower, cavalo, Chinese broccoli, Chinese cabbage (bok choy), Chinese cabbage (napa), Chinese mustard cabbage (gai choy), collards, kale, kohlrabi, mizuna, mustard greens, mustard spinach, rape greens, cucurbits including: cucumber,
  • the animal pest is selected from the order of Lepidoptera, Diptera, Hemiptera, Thysanoptera, Coleoptera, Hymenoptera Heteroptera, Homoptera, Thysanoptera, acarine, nematode and mollusc.
  • Non limiting examples for animal pests that can be controlled by the method of the present invention are selected from Codling moth, European grapevine moth, Leafminers, Leafrollers, Light brown apple moth, Oriental fruit moth, Thrips such as: Chilli, Cuban laurel, western flower; Tufted apple budmoth, Asparagus beetles, Armyworms, Dipteran leafminers, European corn borer, Flea beetle, Loopers, Fireworms, Fruitworms, Moth, Sawfly, Katydids, Worms (caterpillars), Cankerworm, Cabbage Looper, Diamondback Moth, Imported cabbage worm, Worms (caterpillars), Carob moth, borers, moth, fruit flies, Colorado potato beetle, worms (berry moth), cutworms, naval orangeworm, peach twig borer, artichoke plume moth, corn borers, Japanese beetle, Earworm, filbert worm, hus
  • compositions of the present invention are formulated in a simpler manner without rheology modifier while obtaining a product with desired properties under variable range of viscosities. It was unexpected to find that the novel compositions are stable even at low viscosities uncommon in the field of agrochemical formulations.
  • composition of the present invention provide a very effective dispersion and minimum sedimentation of the active ingredient on prolonged storage.
  • a formulation comprising the spinosyn spinosad as detailed in Table 1 was prepared by the following procedure: (i) the reactor was charged with spinosad, Atlas G5002 LQ (as 15% solution in water), Atlox 4913, Silwet L-77, AF OR-IO (half the stated amount) and soft water (313 g/L) while mixing; (ii) high shear was applied and the mixture was milled to get the desired particle size distribution (D90) LT 4 microns; (iii) second portion of soft water (up to 1000 L) and AF OR-IO (second half of the stated amount) were added; (iv) the solution was mixed until a homogenous suspension was obtained.
  • a formulation comprising the spinosyn spinosad as detailed in Table 2 was prepared by the following procedure: (i) the reactor was charged with spinosad, Atlas G5002 LQ (as 15% solution in water), Tersperse 2020, Silwet L-77, AF OR-10 (half the amount) and soft water (313 g/L) while mixing; (ii) high shear was applied and the mixture was milled to get the desired particle size distribution (D90) LT of 4 microns; (iii) second portion of water (up to 1000 L) and AF OR-10 (second half of the stated amount) were added; (iv) the solution was mixed until a homogenous suspension was obtained.
  • a formulation comprising the spinosyn spinosad as detailed in Table 3 was prepared by the following procedure: (i) the reactor was charged with spinosad, Morwet EFW, Atlox 4913, Silwet L-77, AF OR-10 (half the amount) and soft water (313 g/L) while mixing; (ii) high shear was applied and the mixture was milled to get the desired particle size distribution (D90) LT of 4 microns; (iii) second portion of water (up to 1000 L) and AF OR-10 (second half of the stated amount) were added; (iv) the solution was mixed until a homogenous suspension was obtained. Table 3
  • a formulation comprising the spinosyn spinosad as detailed in Table 4 was prepared by the following procedure: (i) the reactor was charged with spinosad, Tween 20, Atlox 4913, Silwet L-77, AF OR-10 (half the amount) and soft water (313 g/L) while mixing; (ii) high shear was applied and the mixture was milled to get the desired particle size distribution (D90) LT of 4 microns; (iii) second portion of water (up to 1000 L) and AF OR-10 (second half of the stated amount) were added; (iv) the solution was mixed until a homogenous suspension was obtained.
  • a formulation comprising the spinosyn spinosad as detailed in Table 5 was prepared by the following procedure: (i) the reactor was charged with spinosad, GenapoleX80, Tersperse 2020, Silwet L-77, AF OR-10 (half the amount) and soft water (313 g/L) while mixing; (ii) high shear was applied and the mixture was milled to get the desired particle size distribution (D90) LT of 4 microns; (iii) second portion of water (up to 1000 L) and AF OR-10 (second half of the stated amount) were added; (iv) the solution was mixed until a homogenous suspension was obtained.
  • a formulation comprising the spinosyn spinosad as detailed in Table 6 was prepared by the following procedure: (i) the reactor was charged with spinosad, Synpronic 13/12-LQ-(AP), Tersperse 2020, Silwet L-77, AF OR-10 (half the amount) and soft water (313 g/L) while mixing; (ii) high shear was applied and the mixture was milled to get the desired particle size distribution (D90) LT of 4 microns; (iii) second portion of water (up to 1000 L) and AF OR-10 (second half of the stated amount) were added; (iv) the solution was mixed until a homogenous suspension was obtained.
  • Example 7 Preparation of spinosad suspension concentrate formulation G (not according to the invention) A formulation comprising the spinosyn spinosad as detailed in Table 7 was prepared by the following procedure: (i) the reactor was charged with spinosad, Synperonic PE64, Tersperse 2020, Silwet L-77, AF OR-10 (half the amount) and soft water (313 g/L) while mixing; (ii) high shear was applied and the mixture was milled to get the desired particle size distribution (D90) LT of 4 microns; (iii) second portion of water (up to 1000 L) and AF OR-10 (second half of the stated amount) were added; (iv) the solution was mixed until a homogenous suspension was obtained.
  • the reactor was charged with spinosad, Synperonic PE64, Tersperse 2020, Silwet L-77, AF OR-10 (half the amount) and soft water (313 g/L) while mixing; (ii) high shear was applied and the mixture
  • This method is intended to determine the suspensibility which is defined as the percentage of one or more active ingredient(s) remaining in suspension after a given time.
  • the method is applicable to formulations forming suspensions on dilution with water at sample concentrations between 0.1 % and 10 %.
  • a suspension of the formulation in Standard Water is allowed to remain undisturbed for a specified time at ambient temperature before the top 9/10ths are drawn off and the remaining l/10th is assayed.
  • the suspensibility is calculated as the percentage of particles remaining suspended.
  • the cylinder was Inverted 30 times for the granules to be fully dispersed.
  • formulations A and B showed no sedimentation (no changes of physical properties) while maintaining relatively low viscosity therefore optimizing the fluidity and display a readily pourable/pumpable concentrate.
  • Formulations C-G (not according to the invention) were highly viscous and had pourability problems.
  • spinosad formulation A To 80 gr taken from spinosad formulation A (see table 1) 7000 gr of water were added thus obtaining spinosad in an amount of about 0.5% by weight.
  • spinosad formulation H To 10 gr taken from spinosad formulation H 240 gr of water were added thus obtaining spinosad in an amount of about 0.02% by weight.

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne de nouvelles compositions de concentré en suspension (SC) comprenant un insecticide à spinosyne, au moins un agent de dispersion et un additif particulier. La présente invention concerne également les compositions décrites qui sont diluées et prêtes à être utilisées. Les compositions de concentré en suspension (SC) de l'invention sont stables et utiles dans la lutte contre les animaux nuisibles.
PCT/IL2024/050700 2023-07-17 2024-07-17 Compositions de concentré en suspension de spinosynes Pending WO2025017554A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011964A1 (fr) * 1999-08-12 2001-02-22 Eli Lilly And Company Formulations de spinosynes ectoparasiticides sous forme de suspension aqueuse
WO2021127126A1 (fr) * 2019-12-19 2021-06-24 Fmc Corporation Compositions de concentré de suspension de diamide
WO2022232921A1 (fr) * 2021-05-04 2022-11-10 Terramera, Inc. Compositions pesticides de spinosyne
WO2022249204A1 (fr) * 2021-05-27 2022-12-01 Rajdhani Petrochemicals Private Limited Composition agrochimique à dispersion d'huile synergique contenant du spinetoram

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011964A1 (fr) * 1999-08-12 2001-02-22 Eli Lilly And Company Formulations de spinosynes ectoparasiticides sous forme de suspension aqueuse
WO2021127126A1 (fr) * 2019-12-19 2021-06-24 Fmc Corporation Compositions de concentré de suspension de diamide
WO2022232921A1 (fr) * 2021-05-04 2022-11-10 Terramera, Inc. Compositions pesticides de spinosyne
WO2022249204A1 (fr) * 2021-05-27 2022-12-01 Rajdhani Petrochemicals Private Limited Composition agrochimique à dispersion d'huile synergique contenant du spinetoram

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Title
"The e-Pesticide Manual, Version 3", April 2003, BRITISH CROP PROTECTION COUNCIL
"The Pesticide Manual Thirteenth Edition", 2003, BRITISH CROP PROTECTION COUNCIL
CORTEVA ET AL: "Produktlabel: Spintor GR - Insektizid", 1 March 2023 (2023-03-01), XP093218545, Retrieved from the Internet <URL:https://www.corteva.de/content/dam/dpagco/corteva/eu/de/de/files/odn/2-seiter_SpintorGR.pdf> *
CORTEVA ET AL: "Specimen Label: Entrust SC - Qalcova active, Naturalyte Insect Control", 7 December 2022 (2022-12-07), XP093218523, Retrieved from the Internet <URL:https://s3-us-west-1.amazonaws.com/agrian-cg-fs1-production/pdfs/Entrust_SC1u_Naturalyte_Insect_Control_Label.pdf> *
DAYAN FECANTRELL CLDUKE SO: "Natural products in crop protection", BIOORG MED CHEM., vol. 17, no. 12, 15 June 2009 (2009-06-15), pages 4022 - 34, XP026152218, DOI: 10.1016/j.bmc.2009.01.046
IGLESIAS LINDSY ET AL: "Evaluating combinations of bioinsecticides and adjuvants for managing Thrips tabaci (thysanoptera: Thripidae) in onion production systems", CROP PROTECTION, ELSEVIER SCIENCE, GB, vol. 142, 31 December 2020 (2020-12-31), XP086471434, ISSN: 0261-2194, [retrieved on 20201231], DOI: 10.1016/J.CROPRO.2020.105527 *
no. 63148-62-9

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