WO2025015104A3 - Apol1 inhibitors and methods of use - Google Patents
Apol1 inhibitors and methods of use Download PDFInfo
- Publication number
- WO2025015104A3 WO2025015104A3 PCT/US2024/037470 US2024037470W WO2025015104A3 WO 2025015104 A3 WO2025015104 A3 WO 2025015104A3 US 2024037470 W US2024037470 W US 2024037470W WO 2025015104 A3 WO2025015104 A3 WO 2025015104A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- apol1
- inhibitors
- tautomers
- stereoisomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided herein are compounds of formula (II) or stereoisomers or tautomers thereof, or pharmaceutically acceptable salts of any of the foregoing, wherein n, m, p, R1, R2, R3, L1, L3, R4, X1, X2, X5, X6, X7, X8, X9, R6, and R7 are as defined herein. Also provided are methods of preparing compounds of formula (II), or stereoisomers or tautomers thereof, or pharmaceutically acceptable salts of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1 -mediated disease, disorder, or condition, such as kidney disease or diabetic retinopathy, in an individual.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363526160P | 2023-07-11 | 2023-07-11 | |
| US63/526,160 | 2023-07-11 | ||
| US202363596120P | 2023-11-03 | 2023-11-03 | |
| US63/596,120 | 2023-11-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2025015104A2 WO2025015104A2 (en) | 2025-01-16 |
| WO2025015104A3 true WO2025015104A3 (en) | 2025-06-05 |
Family
ID=94216344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2024/037470 Pending WO2025015104A2 (en) | 2023-07-11 | 2024-07-10 | Apol1 inhibitors and methods of use |
Country Status (2)
| Country | Link |
|---|---|
| TW (1) | TW202517644A (en) |
| WO (1) | WO2025015104A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL314330A (en) | 2022-01-18 | 2024-09-01 | Maze Therapeutics Inc | APOL1 inhibitors and methods of use |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080306102A1 (en) * | 2007-05-18 | 2008-12-11 | Kowa Co., Ltd. | Novel spirooxyindole compounds and drugs containing same |
| US20160272600A1 (en) * | 2009-03-13 | 2016-09-22 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
| US9957229B2 (en) * | 2004-05-07 | 2018-05-01 | Incyte Holdings Corporation | Amido compounds and their use as pharmaceuticals |
| US20230265096A1 (en) * | 2022-01-18 | 2023-08-24 | Maze Therapeutics, Inc. | Apol1 inhibitors and methods of use |
-
2024
- 2024-07-10 WO PCT/US2024/037470 patent/WO2025015104A2/en active Pending
- 2024-07-10 TW TW113125880A patent/TW202517644A/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9957229B2 (en) * | 2004-05-07 | 2018-05-01 | Incyte Holdings Corporation | Amido compounds and their use as pharmaceuticals |
| US20080306102A1 (en) * | 2007-05-18 | 2008-12-11 | Kowa Co., Ltd. | Novel spirooxyindole compounds and drugs containing same |
| US20160272600A1 (en) * | 2009-03-13 | 2016-09-22 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
| US20230265096A1 (en) * | 2022-01-18 | 2023-08-24 | Maze Therapeutics, Inc. | Apol1 inhibitors and methods of use |
Non-Patent Citations (2)
| Title |
|---|
| DATABASE PUBCHEM COMPOUND 1 December 2012 (2012-12-01), XP093332685, Database accession no. 70594460 * |
| DATABASE PUBCHEM COMPOUND 21 March 2013 (2013-03-21), XP093332686, Database accession no. 71056499 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025015104A2 (en) | 2025-01-16 |
| TW202517644A (en) | 2025-05-01 |
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