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WO2025015034A1 - Système et procédé pour pompe à seringue à force constante recevant des seringues de différentes tailles - Google Patents

Système et procédé pour pompe à seringue à force constante recevant des seringues de différentes tailles Download PDF

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Publication number
WO2025015034A1
WO2025015034A1 PCT/US2024/037360 US2024037360W WO2025015034A1 WO 2025015034 A1 WO2025015034 A1 WO 2025015034A1 US 2024037360 W US2024037360 W US 2024037360W WO 2025015034 A1 WO2025015034 A1 WO 2025015034A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
chamber
constant force
puller
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/037360
Other languages
English (en)
Inventor
Brian Chase
Erik Karlsen
Steven Watts
Peter Smith
Gabriel JEFFER
Derek Roberts
Thomas Blackburn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koru Medical Systems Inc
Original Assignee
Koru Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US18/767,796 external-priority patent/US20250018125A1/en
Application filed by Koru Medical Systems Inc filed Critical Koru Medical Systems Inc
Publication of WO2025015034A1 publication Critical patent/WO2025015034A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms

Definitions

  • the present invention relates generally to mechanical syringe pumps for delivering a liquid medicant to a patient, and more specifically to a mechanical constant force syringe pump advantageously adapting to the different size of each syringe to ensure the proper constant force is applied for dispensation of the liquid medicant to the patient in accordance with the prescribed rate of medicant flow for the presently engaged syringe.
  • Ig Immune Globulin
  • PID Primary Immune Deficiency
  • SID Secondary Immune Deficiency
  • CIPD Chronic Inflammatory Demyelinating Polyradiculoneuropathy
  • SCID Severe Combined Immunodeficiency
  • Subcutaneous Ig therapy is a more convenient option that allows for consistent serum levels and can be done at home.
  • Subcutaneous administrations have been shown to maintain a more constant IgG blood level which provides the patient with a consistent quality of life, and less breakthrough infections.
  • infusion to subcutaneous tissues is often preferred over intravenous delivery which is often accompanied by flu-like symptoms following such intravenous delivery.
  • SCIg has its own challenges, such as the need for patients to prepare and administer the infusions themselves.
  • At least one challenge relates to the pump system used for subcutaneous Ig therapy.
  • the pressure is increased in response to any flow restriction no matter if such a restriction is the build-up of pressure in the patient’s tissues or an element of the delivery system. This can result in an administration of the liquid at an unsafe pressure.
  • the patient may suffer a wide range of symptoms, including, but not limited to, anaphylaxis, overdose, histamine reactions, morbidity, and mortality.
  • a constant pressure pump generates a safe and limited constant pressure. If there is a pinch in the tubing blockage in the infusion system or blockage in the patient’s body (such as by saturation of the tissues), such a blockage results in resistance to the flow and affects the flow rate, not the pressure, i.e., the flow rate decreases as the pressure increases. As such, constant pressure pump systems have been found to be safer and are often more financially acceptable to users.
  • dosage is pre-determined and provided in pre-filled syringes that may be disposed within a constant pressure pump.
  • syringes each person is different in size, shape, and tissue makeup among many factors. Body weight itself could necessitate a prescription for a 17g (85ml) dose for Ig therapy for one person, but only 10g for another person.
  • syringes come in a variety of sizes as well - such as 5, 10, 20 and 50ml, with each varying in length as well as diameter.
  • the patient or caregiver must transfer the liquid medicant from the pre-filled syringe into a new and sterile pump compliant syringe.
  • Such a transfer process is not without issues and introduces the opportunity for problems, such as but not limited to complete transfer, contamination, and general stress and concern.
  • a constant force syringe pump assembly accommodating syringes of different sizes including: a base having a proximal end and a distal end, the base structured and arranged to receive a syringe having a plunger slidably disposed within a chamber having an outlet, the chamber having a length and a diameter, the plunger having a head; a pusher in sliding engagement with the base, the pusher structured and arranged to contact the head of the plunger; a puller in sliding engagement with the base; a sizer structured and arranged to determine the size of the chamber; an adjustable driver structured and arranged to provide a constant force between the pusher and the puller, the constant force adjustably selected by the size of
  • a constant force syringe pump assembly accommodating syringes of different sizes including: an expandable base having a proximal end and a distal end, the base including: a first base section and a second base section, wherein the first base section is in sliding engagement with the second base section such that the first base section and the second base section are slidably movable relative to each other between a compacted position and an expanded position, wherein the base in the expanded position is adapted to seat a syringe having a plunger slidably disposed within a chamber having an outlet, the chamber having a length and a diameter, the plunger having a head; a pusher in sliding engagement with the base, wherein the pusher is dimensioned to contact the head of the plunger; a puller in sliding engagement with the base; a sizer structured and arranged to determine the size of the chamber; an adjustable driver structured and arranged to provide a constant force between the pusher and the puller,
  • a constant force syringe pump assembly accommodating syringes of different sizes including: a base having a proximal end and a distal end, the base structured and arranged to receive a syringe having a plunger slidably disposed within a chamber having an outlet, the chamber having a length and a diameter, the plunger having a head; a pusher in sliding engagement with the base, the pusher structured and arranged to contact the head of the plunger; a puller in sliding engagement with the base; a sizer structured and arranged to determine the size of the chamber; a plurality of different springs, each spring having a first end and a second end, the first end of each spring connected to the pusher, the second end of each spring selectively attached to the puller, the selection of at least one selectively attached spring from the plurality of springs based on the size of the chamber; whereby slidably moving the puller distally when the syringe is
  • a method for using a constant force syringe pump enclosure assembly accommodating syringes of different sizes to dispense a solution from a syringe, including: providing a pump enclosure including: a base having a proximal end and a distal end, the base structured and arranged to receive a syringe having a plunger slidably disposed within a chamber having an outlet, the chamber having a length and a diameter, the plunger having a head; a pusher in sliding engagement with the base, the pusher structured and arranged to contact the head of the plunger; a puller in sliding engagement with the base, the puller structured and arranged to receive a syringe having a plunger set to extrude a liquid from a chamber, the chamber having a length and a diameter; a sizer structured and arranged to determine the size of the chamber; an adjustable driver structured and arranged to provide a constant force between the pusher and the puller,
  • a method for using a constant force syringe pump enclosure assembly accommodating syringes of different sizes to dispense a solution from a syringe, including: providing a pump enclosure comprising: a base having a proximal end and a distal end, the base structured and arranged to receive a syringe having a plunger slidably disposed within a chamber having an outlet, the chamber having a length and a diameter, the plunger having a head; a pusher in sliding engagement with the base, the pusher structured and arranged to contact the head of the plunger; a puller in sliding engagement with the base, the puller structured and arranged to receive a syringe having a plunger set to extrude a liquid from a chamber, the chamber having a length and a diameter; a sizer structured and arranged to determine the size of the chamber; a plurality of different springs, each spring having a first end and a
  • FIG. 1 A is a upper perspective view of a Constant Force Pump For Different Syringe Sizes in an open condition in accordance with at least one embodiment of the present invention
  • FIG. IB is a upper perspective view of a Constant Force Pump For Different Syringe Sizes in an open condition further showing the adjustable driver including a plurality of springs in accordance with at least one embodiment of the present invention
  • FIGs. 2A-2EE present simplified conceptualizations of an at least one embodiment of a sizer of the Constant Force Pump For Different Syringe Sizes for determining the size of a syringe chamber in accordance with at least one embodiment of the present invention.
  • FIGs. 3A-3DD present simplified conceptualizations of yet another embodiment of a sizer of the Constant Force Pump For Different Syringe Sizes for determining the size of a syringe chamber in accordance with at least one embodiment of the present invention.
  • FIGs 4A-4C provide enlarged upper perspective section views of the control rods and engagers of a sizer in operation to engage one or more springs between a pusher and puller of a Constant Force Pump For Different Syringe Sizes in accordance with at least one embodiment of the present invention;
  • FIG. 5 provides an enlarged elevated section view of the puller and pusher and engagement elements of a Constant Force Pump For Different Syringe Sizes in accordance with at least one embodiment of the present invention
  • FIGs. 6A-6C provide side views of the control rods and engagers of a sizer corresponding to FIG. 6 in operation to engage one or more springs between a pusher and puller of a Constant Force Pump For Different Syringe Sizes in accordance with at least one embodiment of the present invention
  • FIG. 7 provides an enlarged elevation view of an alternative puller and pusher and engagement elements of a Constant Force Pump For Different Syringe Sizes in accordance with at least one embodiment of the present invention
  • FIG. 8A-8C provide side views of the control rods and engagers of a sizer corresponding to FIG. 7 in operation to engage one or more springs between a pusher and puller of a Constant Force Pump For Different Syringe Sizes in accordance with at least one embodiment of the present invention
  • FIG. 9 provides an upper perspective view of a Constant Force Pump For Different Syringe Sizes with the cover in a partially closed condition in accordance with at least one embodiment of the present invention
  • FIG. 10 provides a top view of a Constant Force Pump For Different Syringe Sizes in accordance with at least one embodiment of the present invention
  • FIG. 11 provides a flow diagram of a method of using a Constant Force Pump For Different Syringe Sizes for infusion therapy.
  • FIGs. 1A-1B there is shown a mechanical constant force pump as a Constant Force Pump For Different Syringe Sizes, hereinafter CFPDSS 100, for dispensing liquids, e.g., therapeutic liquids, from a variety of different sized syringes in accordance with at least one embodiment of the present invention. More specifically, CFPDSS 100 advantageously determines the size of the syringe so as to apply a proper and predetermined force according to the determined size.
  • CFPDSS 100 advantageously determines the size of the syringe so as to apply a proper and predetermined force according to the determined size.
  • CFPDSS 100 To facilitate the description of systems and methods for embodiments of CFPDSS 100, the orientation of CFPDSS 100 as presented in the figures is referenced to the coordinate system with three axes orthogonal to one another as shown in FIG. 1 A. The axes intersect mutually at the origin of the coordinate system, which is chosen to be the center of CFPDSS 100, however the axes shown in all figures are offset from their actual locations for clarity and ease of illustration.
  • CFPDSS 100 is structured and arranged to advantageously operate with a variety of different sized syringes, of which syringe 102 is merely exemplary.
  • syringe 102 has been illustrated both disposed within the CFPDSS 100, and removed for ease of identification of various elements.
  • a typical preloaded syringe 102 for use in an infusion treatment may be generally described as having a syringe barrel 104 which at a first end 106 provides an outlet 108 suitable for attachment to, or already fitted with, tubing suitable for administering the liquid in the syringe barrel 104.
  • this first end of 104 the syringe 102 is tapered so as to reduce the overall size of the syringe 102 from the diameter of the barrel 104 to one suitable for fluid connection with tubing.
  • the barrel 104 of the syringe 102 also defines the chamber 110 of the syringe 102 which contains the liquid medication (shown as dots 112) to be dispensed.
  • the diameter 114 of the chamber 110 is generally consistent along its length 116, and in most cases the length 116 of the chamber 110 and the diameter 114 of the chamber 110 are substantially the same as the diameter and length of the syringe barrel 104, save for the addition of the thickness of the material from which the syringe barrel 104 is formed.
  • the diameter 114 of the barrel 104 and diameter 114 of the chamber 110 may be used interchangeably, likewise the length 116 of the barrel 104 and length 116 of the chamber 110 may be used interchangeably
  • a plunger seal 118 is disposed in the open end 120 of the syringe barrel 104, opposite from the first end 106.
  • a plunger 122 extends rearward from the plunger seal 118 and is typically about the same length as the syringe barrel 104. As pressure is applied to the head 124 of the plunger 122, the plunger seal 118 is advanced towards the first end 106 of the syringe 102, and the liquid (shown as dots 112) within the syringe 102is expelled through the outlet 108.
  • a syringe 102 provides finger tabs 126 disposed proximate to the open end 120 of the syringe 102 such that a user may grasp the tabs with his or fingers and then exert pressure upon the head of the syringe 102 with his or her thumb, palm, or other hand.
  • the finger tabs 126 provide a brace for the syringe barrel 104 as the plunger seal 118 is driven into and through the syringe barrel 104 by the plunger 122.
  • the finger tabs 126 may be, it will be understood and appreciated that the first end 106 of the syringe 102 may also be used as a base during the extrusion process.
  • the first end 106 may be fitted with a luer, such as a disc luer, in which case the disc portion of the luer may act as the base during the extmsion process.
  • the luer 200 is a flared luer as set forth in US Patent 10,500,389 entitled, SYSTEM AND METHOD FOR FLARED LUER CONNECTOR FOR MEDICAL TUBING, incorporated herein by reference.
  • the lure 200 is a tapered luer as set forth in US Provisional Application 63/616,368 entitled, SYSTEM AND METHOD FOR A TAPERED LURE CONNECTOR FOR MEDICAL TUBING, incorporated herein by reference.
  • the syringe barrel 104 must be braced by some element and the plunger 122 must be braced. A force is then applied to move the plunger 122 towards the first end 106.
  • the user may actually move the two components, it will also be understood and appreciated that the first end 106 can be pushed backwards towards the plunger 122, or the plunger 122 can be pushed forwards toward the first end 106.
  • the CFPDSS 100 it is an advantageous aspect of the CFPDSS 100 to receive a syringe 102 as has just been described, brace the first end 106 of the syringe 102 and brace the head 124 of the plunger 122, and then apply a constant force as between the first end 106 and the head 124 of the plunger 118 so as to drive the plunger seal 118 forward and extrude the liquid from the syringe 102.
  • the syringe 102 is braced by the finger tabs 126 rather than the first end 106.
  • the bracing by the finger grips 126 ensures that the plunger seal 118 is driven forward towards the first 106 to extrude the liquid from the syringe 102.
  • the CFPDSS 100 builds from the Applicant’s prior developments with compact mechanical pumps as set forth in US Patent 10,376,636, which is incorporated herein by reference.
  • the ‘636 patent specifically teaches that if a person should try to dispose a 30ml syringe in a pump suited for a 20ml Syringe, ejection ramps will eject the Syringe from pump housing when the user attempts to close the housing, the present invention advantageously accommodates syringes 102 of different sizes.
  • the CFPDSS 100 has a housing 128 having a distal end 130 and a proximal end 132.
  • the housing 128 is provided by a base 134 and a cover 136 that are hinged at the proximal end 132 to permit opening and closing.
  • the base 134 and a cover 136 are fixed in size.
  • the base 134 and a cover 136 are both expandable.
  • the base 134 is provided by a first base section and a second base section, wherein the first base section is in sliding engagement with the second base section such that the first base section and the second base section are slidably movable relative to each other between a compacted position and an expanded position.
  • the cover 136 is provided by a first cover section and a second cover section, wherein the first cover section is in sliding engagement with the second cover section such that the first cover section and the second cover section are slidably movable relative to each other between a compacted position and an expanded position.
  • the base 134 and cover 136 transition between compact and expanded states at the same time. Embodiments of such a compacting / expanding base 134 and cover 136 may be extrapolated from ‘636 patent noted above.
  • the CFPDSS 100 also includes a dampener 138 to dampen the opening motion of the cover 136.
  • the dampener 138 may be separate from the hinge 140 and pivotally coupled to base 134 and a cover 136, or integrated as an element of the hinge 140. Whether a separate element from the hinge 140 or an incorporated part of the hinge 140, for at least one embodiment the dampener 138 is selected from a viscus dampener, a fluid dampener, a rotary friction dampener or the like.
  • the CFPDSS 100 may include a latch or lock assembly for keeping the cover 136 in a closed position upon the base 134.
  • a puller 142 Within the housing 128, and more specifically disposed upon the base 134 are a puller 142, a pusher 144, a collar 146, a sizer 148, and a selector 150.
  • an adjustable driver 152 structured and arranged to provide a constant force between the pusher 144 and the puller 142, this constant force adjustably selected by the size of the syringe 102, and more specifically the size of the chamber 110 of the syringe 102.
  • the size of the chamber 110 may be determined generally in two ways - by determining the length 116 of the chamber 110 or by determining the diameter 114 of the chamber 110.
  • the pusher 144, the puller 142 and the selector 150 are slidingly engaged upon a track 154 or tracks provided by the base 134.
  • the puller 142 has movable linkage 156, linking the puller 142 with the cover 136, such that movement of the cover 136 between an open and closed position imparts sliding motion of the puller 142 along the track(s) of the base 134. More specifically, as the cover 136 is lowered for closing, the linkage 156 moves the puller 142 towards the distal end 130, and when the cover 136 is raised for opening, the linkage 156 moves the puller 142 towards the proximal end 132.
  • cover 136 and base are pivotally connected at one end
  • an alternative embodiment may be provided where the cover 136 slides longitudinally over the base, the movable linkage 156 linking the puller 142 with the cover 136 being mechanically adapted for activation through the sliding of the cover 136 between an open and closed position as oppose to rotation.
  • CFPDSS 100 is advantageously structured and arranged to accommodate a plurality of different syringe sizes - e.g., a syringe having a volume of at least 5 milliliters to a syringe having 120 milliliters - it will be understood and appreciated that CFPDSS 100 advantageously permits a different constant force to be applied to each of the different sized syringes. It is this different constant force that is provided by the adjustable driver 152.
  • the adjustable driver 152 is provided, at least in part, by a plurality of different springs that may be selectively engaged between the pusher 144 and the puller 142. It will be understood and appreciated that other options for an adjustable driver 152 structured and arranged to provide a constant force between the pusher 144 and the puller 142 that is determined by the size of the syringe 102.
  • One such alternative embodiment is provided by at least one spring engaged between the pusher 144 and the puller 142 and at least one braker associated with the at least one spring (not shown) - the braker providing an adjustable braking force to the at least one associated spring, the braking fore applied based on the size of the syringe 102 as determined by the size of the chamber.
  • the collar 146 is disposed in a fixed position upon the base 134, however it will be understood and appreciated that in at least one alternative embodiment the collar 146 may also be slidingly engaged upon a track or tracks provided by the base 134.
  • the collar 146 may be provided by essentially two side elements that may be adjusted by the user outward or inward so as to firmly grip the syringe barrel 104.
  • Various alternatives such as, but not limited to, compliant materials that will compress or expand as required by the diameter of the syringe barrel 104 may also be used, so as to permit the collar 146 to firmly / snuggly grip the syringe barrel and / or provide brace support for the finger tabs of the syringe 102.
  • a syringe 102 is shown as disposed within the CFPDSS 100. More specifically the finger tabs at the open end of the syringe barrel 104 are shown to be engaged with the collar 146, and the first end 106 of the syringe 102 is shown seated with the selector 150.
  • the selector 150 is selectively movable between multiple positions, which for at least one embodiment are the varying, and distinctly different barrel lengths of a 50ml syringe 102, a 20ml syringe 102, a 10ml syringe 102, and a 5ml syringe 102.
  • a spring may bias the selector 150 to be disposed proximate to the collar 146.
  • the first end 106 of the syringe 102 is partially disposed in a seat 158 provided by the selector 150.
  • the selector 150 is slid away from the collar 146 to a distinct position appropriate for the size of the syringe 102.
  • the selector 150 and more specifically the seat 158 of the selector may be structured and arranged as an accepting base for such a tapered or flared luer.
  • the size of the syringe 102 is determined by length 116 of the syringe 102, and more specifically the length 116 of the syringe barrel 104 / chamber 110.
  • the collar 146 which has received the finger tabs 126 and is bracing them is providing the brace for the syringe 102, much as the fingers of a human operator would.
  • the collar 146 and the selector 150 both provide brace for the syringe barrel 104.
  • each distinct position has a binder 160 such that once the selector 150 is slid to a desired position it may be temporarily bind to the base 134 at that position.
  • the binder 160 is provided by notches in the base 134 and ridges extending from the selector 150. When the selector 150 is grasped and tilted slightly up, the ridges are removed from the notches and the selector 150 may be moved to a new position. Once repositioned, the selector 150 is pressed down and the ridges are then depressed into corresponding notches such that the selector 150 will remain in the chosen position until it is tilted up once again to disengage the ridges from the notches.
  • the selector 150 is a component of a sizer 148 - which is structured and arranged to determine the size of the chamber of the syringe 102 disposed in the CFPDSS 100, and more specifically seated between the selector 150 and the collar 146.
  • the sizer 148 is a mechanical system provided at least in part by the selector 150 and at least one selector or control rod or bar that mechanically interconnects the selector 150 with the puller 142.
  • the adjustable driver 152 is shown with a covering 162 in place.
  • the cover 162 has been removed, and for the exemplary embodiment shown, the adjustable driver 152 is appreciated to be a plurality of tape springs 164, of which tape springs 164A, 164B, 164C and 164D are exemplary and shown in FIG. IB.
  • each of the one or more control rod(s) / bar(s) 168 may be further described as a lever - having a low section and a high section.
  • the one or more control rod(s) / bar(s) / lever(s) 168 may be slid a sufficient distance such that the low section transitions to a high section, the high section activating the selection of an associated tape spring 164.
  • mechanical determination of the size of the syringe 102 is, for at least one embodiment determined by the movement of the selector 150 towards the distal end 130 as the syringe 102 is disposed into the CFPDSS 100. More specifically, the user disposes the first end 106 of the syringe 102 into the seat 158 of the selector 150 and pushes the selector 150 towards the distal end 130 so as to bring the finger tabs 126 into position to be disposed into the collar 146.
  • the longitudinal movement of the selector 150 within the housing 128 along the base 134 is triggers one or more control rod(s) / bar(s) / lever(s) to selectively couple one or more tape springs 164 provided by the pusher 144 to the puller 142.
  • the terms “rod” / “bar” / “lever” with respect to the controlling linkage triggering the engagement of the first end 166 of a selected tape spring 164 may be used interchangeably.
  • the pusher 144 As the puller 142 will be held substantially in place by the linkage 156 when the cover 136 is closed, it is the pusher 144 which will then slide towards the puller 142.
  • the pusher 144 has a plunger receiver 170 which is structured and arranged to contact the head 124 of the plunger 122.
  • the plunger receiver 170 does not just contact, but engages with the head 124 of the plunger 122 such as by providing a seat or basin which may help to center the plunger 122 and avoid possible slide slippage when and as force is applied to the plunger 122.
  • the tape spring(s) 164 imparted force drawing the pusher 144 towards the puller 142 is thereby applied to the plunger 122 - driving it into the syringe barrel 104 and extruding the liquid from the outlet 108 at the first end 106.
  • the sizer 148 - provided by the exemplary embodiment of the selector 150, the control rod(s) / bar(s) / lever(s) 168 and the selected engagement of the first ends 166 of one or more tape springs 164 advantageously ensures that the force provided by the engaged tape springs 164 is a pre-determined forced appropriate for the size of the syringe 102 that has been disposed within CFPDSS 100.
  • FIGs. 2 A-2EE and FIGs. 3A-3DD This mechanical selection of tape springs 164 based on position of the selector 150 may be more fully appreciated with respect to the conceptual illustrations presented in FIGs. 2 A-2EE and FIGs. 3A-3DD.
  • the CFPDSS 100 system has been simplified for demonstration with three tape springs 164 and how they are selectively attached to the puller 142.
  • the tape springs 164 are understood and appreciated to be disposed on the pusher 144, but for the sake of ease of illustration and discussion, the distinct element of the pusher 144 as well as the syringe 102, cover 136, and collar 146 have been omitted in FIGs. 2A-2EE and 3 A-3DD to help emphasize and clarify the conception of selective attachment of the tape springs 164 to the puller 142.
  • FIG. 2A-2EE at the top of the drawing page is shown a top view (FIG. 2A, 2B, 2C, 2D, 2E) of simplified CFPDSS 100 and at the bottom is shown a corresponding perspective view (FIG 2AA, 2BB, 2CC, 2DD, 2EE) of simplified CFPDSS 100.
  • FIG. 2A the system is at rest, and none of the tape springs 164 have been engaged.
  • 2B & 2BB, 2C & 2CC, 2D & 2DD, and 2E & 2EE each illustrate how different syringes having different lengths advantageously mechanically trigger different engagements of tape springs 164, thus advantageously assuring and permitting CFPDSS 100 to provide the correct constant force to plunger 122 of syringe 102 disposed within
  • FIG.s 2A & 2AA three tape springs 164A, 164B, 164C are shown each with a first end 166 disposed over a puller 142. Below the puller 142 and first end 166 of each tape spring 164 is an engager 200, and each engager 200 is disposed upon the end of an associated control rod 168, which for the illustrated example is a lever 202.
  • a selector 150 is shown disposed over the base 134, and each of the three levers 202A, 202B, 202C is shown to have an activator 204A, 204B, 204C.
  • FIGs. 2B & 2BB conceptualizing the insertion of a syringe having a first length
  • the selector 150 has been slid forward and has now depressed the activator 204A of the first lever 202A.
  • the other end of the lever 202A is elevated such that the engager 200A is now disposed to engage the first end 166A of tape spring 164A to the puller 142.
  • the engager 200A is shown as a distinct element, such that once engaged, it can move with the puller 142 and thereby maintain attachment between the puller 142 and tape spring 164A even when the puller 142 is slid away from the springs - as occurs when the cover is closed such that the linkage 156 (not shown in FIGs. 2B & 2BB) causes the puller 142 to slide away from the pusher 144.
  • FIGs. 2C & 2CC conceptualizing the insertion of a syringe having a second length
  • the selector 150 has been slid to a second position and is now so disposed that the first and second activators 204A & 204B are both triggered, and correspondingly the engagers 200A & 200B for both tape spring 164A and tape spring 164B have been elevated for temporary attachment of their respective first ends 166A & 166B to the puller 142.
  • FIGs. 2D & 2DD conceptualizing the insertion of a syringe having a third length
  • the selector 150 has been slid to a third position, and now all three activators 204A & 204B & 204C have been triggered such that all three tape springs 164A, 164B and 164C are temporarily attached by their respective engager 200A, 200B, 200C to the puller 142.
  • FIGs. 2E & 2EE conceptualizing the insertion of a syringe having a fourth length, a variation of the selector 150 has been shown wherein the first and third activators 204A & 204C are triggered, but the second activator 204B is not. As such, tape springs 164A and 164C are temporarily attached to the puller 142, but tape spring 164B is not.
  • the CFPDSS 100 adaptively provides pressure from about 5 psi to about 30 psi.
  • CFPDSS 100 advantageously and adaptively changing combinations of tape springs 164 ensures that the selected pre-determined constant force is appropriate to the size of the chamber, thus ensuring an outflow rate from the syringe chamber 110 that does not exceed a pre-determined rate.
  • each of the tape springs 164 may be substantially identical, at least two tape springs 164 may be substantially identical, and/or each tape spring 164 is distinctly different. More specifically, the use of at least four tape springs 164 may be selectively chosen so as to provide the proper constant force for a plurality of different, yet common, pre-filled syringes as may be desired and used in infusion therapy regimes.
  • FIGs. 3 A-3DD provide a simplified conceptual overview of an alternative embodiment of the tape spring 166 selection process as achieved by an embodiment of CFPDSS 100 incorporating tapered control rods 300.
  • FIGs. 3A-3DD at the top of the drawing page is shown a top view of CFPDSS 100 (FIGs. 3A, 3B, 3C, 3D) and at the bottom is shown a corresponding perspective view of CFPDSS 100 (FIGs. 3 AA, 3BB, 3CC, 3DD).
  • a reference view of the control rods 168 which for the present illustrations are identified as control rods 300A, 300B, and 300C.
  • each control rod 300 and more specifically control rods 300A, 300B, and 300C is appreciated to have a low section 302A, 302B, and 302C and a high section 304A, 304B, and 304C.
  • each control rod 300 has a different profile as each has a high section 304 of a different length.
  • control rod 300A has been illustrated with a telescoping slide arrangement such that a portion of the low section 302A may be slid into the portion of control rod 300A providing the high section 304A.
  • this arrangement may be reversed in an alternative embodiment wherein the portion of the control rod 300A providing the high section 304A slides into the portion of the control rod 300A providing the low section.
  • control rods 300 would be incorporated in alternative embodiments noted above where the base 134 and cover 136 are also configured to have a sliding arrangement as between a compact for storage and extended for use state of configuration.
  • each of the control rods 300A, 300B, 300C is disposed in an initial position under the tape springs 164A, 164B, 164C such that all of the high sections 304A, 304B, and 304C are away from the engagers 200A, 200B, 200C, which are at present disposed above the low section 302A, 302B, and 302C of each control rod 300 A, 300B, 300C.
  • FIGs. 3B & 3BB conceptualizing the insertion of a first syringe having a first length
  • the selector 150 has been advanced longitudinally away from the tape springs 164 to a first position for a first syringe
  • the first selector rod 300A has now moved as well such that the high section 302A is now disposed below the engager 200A which has been lifted up so as to engage tape spring 164A to the puller 142.
  • 3C & 3CC conceptualizing the insertion of a syringe having a second length
  • the selector 150 has advanced longitudinally away from the tape springs 164 to a second position for a second syringe which is of a size different from the first syringe.
  • both the first and second control rods 300A & 300B have been moved a sufficient distance such that both high sections 304A & 304B are now disposed beneath engagers 200A & 200B such that both tape springs 164A & 164B are now selectively engaged to the puller 142.
  • the selector 150 has advanced longitudinally away from the tape springs 164 to a third position for a third syringe which is of a size different from both the first syringe and the second syringe.
  • all three control rods 300A, 300B, 300C have been moved a sufficient distance such that all high sections 304A, 304B, 304C are now disposed beneath engagers 200A, 200B, and 200C such that all three springs are now selectively engaged to the puller 142.
  • At least a fourth option for at least a fourth length of a syringe may also be provided, corresponding at least in part to FIGs. 2E & 2EE where an aperture may be provided such that two or more control rods 300 are engaged while at least one control rod 300 is not.
  • selector 150 may be incorporated as an element of the collar 146.
  • the collar 146 may be provided by essentially two side elements that may be adjusted by the user outward or inward so as to firmly grip the syringe barrel 104. It will be understood and appreciated that activation of the control rods 168/202/300 as described above may be achieved by linkage between the side elements of the collar and the control rods 168/202/300. Such linkage may be in the form of gears, arms, levers or other elements that are structured and arranged to translate lateral movement of the side elements of the collar 146 into longitudinal movement of the control rods 168/202/300.
  • the size of the syringe 102, and more specifically the chamber 110 / barrel 104 is determined by the length 116 of the chamber 110 as determined by the longitudinal moving selector 150 as conceptualized in FIGs. FIGs 2A-2E and FIGs 3A-3D.
  • the size of the syringe 102, and more specifically the chamber 110 / barrel 104 is determined by the diameter 114 of the chamber 110 as determined by a selector 150 provided by laterally moving side elements of the collar 146.
  • sizer 148 may be an electrical system.
  • the sizer 148 incorporates a Hall effect sensor. More specifically, magnets are disposed into the base 134 and the selector 150 or collar 146. As the selector 150 and/or collar 146 are slid on one direction or another, magnets attached thereto are sensed by a Hall effect sensor array, as may be provided by a printed circuit board (PCB). This sensed signal is interpreted by one or more computer chips utilizing a position algorithm to determine the length of the syringe barrel, the computer chips then triggering one or more engagers 200 (such as for example solenoids) to selectively attach one or more tape springs 166 to the puller 142.
  • engagers 200 such as for example solenoids
  • the sizer 148 is provided at least in part by a resistive strip.
  • movement of the selector 150 or collar 146 is detected by a wiper moving along a resistive strip.
  • This sensed change in resistance is interpreted by one or more computer chips utilizing a position algorithm to determine the length of the Syringe barrel, the computer chips then triggering one or more engagers 200 (such as for example solenoids) to selectively attach one or more tape springs 166 to the puller 142.
  • the sizer 148 is provided is provided at least in part by a laser system measuring time of flight (TOF).
  • TOF time of flight
  • a laser beam is activated to strike a target mounted on an element that is understood and appreciated to move so as to properly accommodate a syringe - e.g. the selector 150 or collar 146.
  • Laser light reflected back by the target is captured by a sensor.
  • This time elapsed between emission of the laser and sensing of the bounced return is interpreted by one or more computer chips utilizing a position algorithm to determine the length of the syringe barrel, the computer chips then triggering one or more engagers 200 (such as for example solenoids) to selectively attach one or more tape springs 166 to the puller 142.
  • engagers 200 such as for example solenoids
  • FIGs 4A-4C present enlarged partial illustrations of the control rods 168 and engagers 200, and their progression of operation. More specifically, in FIG. 4A the CFPDSS 100 is at rest and no syringe has yet been disposed engaged to the collar and selector (not shown). In FIG. 4B, a syringe has now been disposed within CFPDSS 100, and the selector has been moved from a first position at rest to a second position now indicative of the length of the syringe barrel.
  • this movement of the selector 150 has triggered the movement of at least one control rod 168, and as shown clearly, exemplary control rod 168A has moved to lift the engager 200A so as to engage the first end 166A of tape spring 164A to the puller 142.
  • exemplary control rod 168A has moved to lift the engager 200A so as to engage the first end 166A of tape spring 164A to the puller 142.
  • multiple control rods have been engaged resulting in at least engagers 200A and 200B engaging first ends 166A & 166B of their associated tape springs 164A & 164B.
  • the puller 142 has been slid away from the pusher 144 and it may be appreciated that all four (4) of the selectable tape springs 164A, 164B, 164C and 164D have been engaged by their first ends 166A, 166B, 166C and 166D to the puller 142. It may also be appreciated that for at least one embodiment, one tape spring, such as 164E (not shown in FIG. 4C - see FIG. 5 A) is permanently affixed between the puller 142 and the pusher 144. For the embodiment as shown, this is the middle tape spring 164E, the first end affixed to the puller 142 by a fixed attacher 400, such as a screw.
  • a fixed attacher 400 such as a screw.
  • FIG. 5 is an elevated partial perspective showing a similar subsection of CFPDSS 100 as show in in FIG. 4C, FIG. 5 illustrated from a higher view angle.
  • the plunger receiver and other elements have been removed so as to provide an enhanced view of the engagement between the puller 142 and the first ends 166 of at least some tape springs 164.
  • the condition of tape spring 164E as permanently attached between the puller 142 and the pusher 144 is more clearly illustrated.
  • tape spring 164C has been selectively engaged to the puller 142, but tape spring 164A, 164B and 164D have not. More specifically, engager 200C is shown engaging with first end 164C, but engagers 200A, 200B, 200D are shown in their undeployed, and therefore non-engaging state.
  • FIGs 6A-6C present enlarged partial illustrations of yet another embodiment of CFPDSS 100 wherein the control rods 168 are tapered control rods 300 having low sections 302 and high sections 304 as discussed above with respect to FIGs. 3A-3DD, and their progression of operation.
  • each control rod 168/300 is moved longitudinally within the housing as the selector 150 is moved longitudinally.
  • the selection of a specific tape spring is achieved by its associated control rod 168 moving a sufficient lateral distance to transition from the low section 302 to the high section 304, such that the engager 200 is pressed up so as to engage the first end 166 of its associated tape spring 164.
  • each control rod 168 as shown in Figs. 6A-6C may be a telescoping control rod or bar as discussed above.
  • the telescoping nature of each control rod 168 permits a first portion to move within the second portion (or vice versa) but when the CFPDSS 100 is expanded so as to receive a syringe, the first portion locks with the second portion to provide the full-length control rod 168.
  • springs (not shown) may be disposed between the second portion and the hinge end of the CFPDSS 100 to retard lateral motion of the second portion of each control rod unless and until the first portion has fully retracted.
  • the illustrated embodiment utilizes the tapered pins 500 as the first ends 166 of the tape springs 164 (see FIG. 7 for tape springs 164). More specifically, in FIG. 6A the CFPDSS 100 is at rest and no syringe 102 has yet been disposed engaged to the collar 146 and selector 150 (not shown).
  • FIG. 6B a syringe 102 (not shown) has now been disposed within CFPDSS 100, and the selector 150 (not shown) has been moved from a first position at rest to a second position now indicating the length of the syringe barrel.
  • this movement of the selector 150 has triggered the movement of at least one control rod 168, and as shown clearly, exemplary control rod 168A/300A has moved such that the high section 304 is now below the engager 200A so as to lift the engager 200A to engage the first end 166A/500A of tape spring 164A to the puller 142.
  • a gap 600 between the engager 200A and the first end 166A/500A of tape spring 164A see FIG. 7).
  • FIG. 6C shows a partial perspective view of an embodiment of CFPDSS 100 utilizing tapered pins 500 as the first ends 166 of the selectable tape springs 164, and sockets 502 for advantageously improved alignment and engagement of the first ends 500/166.
  • FIG. 7 shows a partial perspective view of an embodiment of CFPDSS 100 utilizing tapered pins 500 as the first ends 166 of the selectable tape springs 164, and sockets 502 for advantageously improved alignment and engagement of the first ends 500/166.
  • tapered pins 500 self-align to their corresponding receiving sockets 502. As they are self-aligned, the engagement of an engager 200 (not shown in FIG. 7) for the selection of a tape spring 164 is likely improved.
  • FIGs. 8A-8C presents a sequence of enlarged partial side views of the base 134 showing the puller 142, the pusher 144, a control rod 168/300 as well the engager 200 disposed below the first end 166/500 of a tape spring 164 for selective attachment to the puller 142.
  • CFPDSS 100 is essentially at rest as no syringe has yet been disposed and control rod 168A/300A is in its initial position with the low section 302 beneath engager 200.
  • FIG. 8B a syringe has now been disposed within CFPDSS 100 such that the selector 150 (not shown) has been disposed towards the distal end 130 (not shown), which has resulted in the longitudinal movement of control rod 168A/300A towards distal end 130.
  • the high section 304 has now moved to be beneath engager 200A, and consequently engager 200A has been raised up for engagement with first end 166A/500A.
  • the cover 136 (not shown) has been at least partially closed, so as to engage the linkage 156 (not shown) to move the puller 142 away from the pusher 144, drawing out tape spring 164A as the first end 166A/500A is engaged by engager 200A to the puller 142.
  • closing the cover 136 tensions the selectively engaged tape springs 164, as the puller is moved towards the distal end 130 of CFPDSS 100.
  • FIG. 9 is a top perspective view of CFPDSS 100 with the cover now shown to be moving down to the closed position. As such, it may be appreciated that the linkage between the cover and the pusher 144 has advanced the pusher 144 away from the puller 142 and towards the distal end 130. It is this action that has been shown in the partial enlarged side views of FIGs. 8A-8C.
  • FIG. 10 is presented as a top view of CFPDSS 100 further permitting an appreciation of the above-described elements, such as, but not limited to the puller 142, the pusher 144, the collar 146, the sizer 148, the selector 150 and the adjustable driver 152.
  • a base 134 having a proximal end 132 and a distal end 130, the base 134 structured and arranged to receive a syringe 102 having a plunger 122 slidably disposed within a chamber 110 having an outlet 108, the chamber 110 having a length 116 and a diameter 114, the plunger 122 having a head 124; a pusher 144 in sliding engagement with the base 134, the pusher 144 structured and arranged to contact the head 124 of the plunger 122; a puller 142 in sliding engagement with the base 134; a sizer 148 structured and arranged to determine the size of the chamber 110; an adjustable driver 152 structured and arranged to provide a constant force between the pusher 144 and the puller 142, the constant force adjustably selected by the size of the chamber 110; whereby
  • an expandable base 134 having a proximal end 132 and a distal end 130, the base 134 including: a first base 134 section and a second base 134 section, wherein the first base 134 section is in sliding engagement with the second base 134 section such that the first base 134 section and the second base 134 section are slidably movable relative to each other between a compacted position and an expanded position, wherein the base 134 in the expanded position is adapted to seat a syringe 102 having a plunger 122 slidably disposed within a chamber 110 having an outlet 108, the chamber 110 having a length 116 and a diameter 114, the plunger 122 having a head 124; a pusher 144 in sliding engagement with the base 134, wherein the pusher 144 is dimensioned to contact the head 124 of the plunger 122; a puller 142 in sliding engagement with the base 134;
  • yet another embodiment of a CFPDSS 100 may be summarized as: a base 134 having a proximal end 132 and a distal end 130, the base 134 structured and arranged to receive a syringe 102 having a plunger 122 slidably disposed within a chamber 110 having an outlet 108, the chamber 110 having a length 116 and a diameter 114, the plunger 122 having a head 124; a pusher 144 in sliding engagement with the base 134, the pusher 144 structured and arranged to contact the head 124 of the plunger 122; a puller 142 in sliding engagement with the base 134; a sizer 148 structured and arranged to determine the size of the chamber 110; a plurality of different springs, each spring having a first end and a second end, the first end of each spring connected to the pusher 144, the second end of each spring selectively attached to the puller 142, the selection of at least one selectively attached spring from the pluralit
  • KORU Medical Systems, Inc. of Mahwah, New Jersey is and has been a pioneer in infusion pump technology, needle set technology and flow rate control by means of specifically engineered flow control tubing. Indeed, KORU has realized that different flow rates may be provided by working with different flow combinations of flow control tubing, such as those systems and methods set forth in US Patent 10,420,886 entitled MULTI-FLOW UNIVERSAL TUBING SET, incorporated herein by reference, and US Patent 10,709,839 entitled PRECISION VARIABLE FLOW RATE INFUSION SYSTEM AND METHOD, incorporated herein by reference.
  • KORU has developed advantageous infusion systems permitting high flow at low pressure as set forth in US Application 17/729,914 published as US 2022/0265923 entitled HIGH FLOW AT LOW PRESSURE INFUSION SYSTEM, incorporated herein by reference.
  • the needle hub 100 is the snap in needle structure shown and described as element 162 in US Patent Application 18/216,342 entitled SYSTEM AND METHOD FOR BUTTERFLY NEEDLE ASSEMBLY, incorporated herein by reference.
  • CFPDSS 100 may serve as the constant force pump for infusion therapy provided to a patient incorporating one or more of the above identified technologies.
  • a lure such as the flared luer as set forth in US Patent 10,500,389 entitled, SYSTEM AND METHOD FOR FLARED LUER CONNECTOR FOR MEDICAL TUBING or a tapered luer as set forth in US Provisional Application 63/616,368 entitled, SYSTEM AND METHOD FOR A TAPERED LURE CONNECTOR FOR MEDICAL TUBING
  • the selector 150, and more specifically the seat 158 of the selector may be structured and arranged as an accepting base for such a tapered or flared luer.
  • method 1100 commences with providing a CFPDSS 100, block 1102.
  • CFPDSS 100 is structured and arranged to use a sizer 148 to determine the size of the disposed syringe 102 and mechanically engage and adjustable driver 152 to provide a pre -determined constant force appropriate for the disposed syringe, block 1106.
  • CFPDSS 100 is advantageously structured and arranged to determine the size of the syringe, and then the predetermined constant force for the syringe based on the determined size, it will be understood and appreciated that the same CFPDSS 100 may be used for the infusion therapy treatment of different sized syringes without adverse effects from improper force applied for the administration. Moreover, a single CFPDSS 100 is advantageously capable of self-determining different syringe sizes and automatically selecting the pre-determined constant force appropriate for the administration of the medicate within a syringe of a determined size.
  • a method for using a CFPDSS 100 may be summarized as: providing a pump enclosure including: a base 134 having a proximal end 132 and a distal end 130, the base 134 structured and arranged to receive a syringe 102 having a plunger 122 slidably disposed within a chamber 110 having an outlet 108, the chamber 110 having a length 116 and a diameter 114, the plunger 122 having a head 124; a pusher 144 in sliding engagement with the base 134, the pusher 144 structured and arranged to contact the head 124 of the plunger 122; a puller 142 in sliding engagement with the base 134, the puller 142 structured and arranged to receive a syringe 102 having a plunger 122 set to extrude a liquid from a chamber 110, the chamber 110 having a length 116 and a diameter 114; a

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne une pompe à force constante recevant des seringues de différentes tailles (100). Le système comprend une enceinte (128) ayant une base (134) ayant une extrémité proximale (132) et une extrémité distale (130), la base (134) étant structurée et agencée pour recevoir une seringue (102) ayant un piston (122) disposé de manière coulissante à l'intérieur d'une chambre (110) ayant une sortie (108), la chambre (110) ayant une longueur (116) et un diamètre (114), le piston (102) ayant une tête (124) ; un poussoir (144) en prise coulissante avec la base (134), le poussoir (144) étant structuré et agencé pour entrer en contact avec la tête (124) du piston (122) ; un dispositif de traction (142) en prise coulissante avec la base (134) ; un calibreur (138) structuré et agencé pour déterminer la taille de la chambre (110) ; un dispositif d'entraînement réglable (152) structuré et agencé pour fournir une force constante entre le poussoir (144) et le dispositif de traction (142), la force constante étant sélectionnée de manière réglable par la taille de la chambre (110). L'invention concerne également un procédé associé (1100) d'utilisation.
PCT/US2024/037360 2023-07-11 2024-07-10 Système et procédé pour pompe à seringue à force constante recevant des seringues de différentes tailles Pending WO2025015034A1 (fr)

Applications Claiming Priority (4)

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US202363526050P 2023-07-11 2023-07-11
US63/526,050 2023-07-11
US18/767,796 US20250018125A1 (en) 2023-07-11 2024-07-09 System and method for a constant force syringe pump accomodating syringes of different sizes
US18/767,796 2024-07-09

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298000A (en) * 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4681566A (en) * 1984-11-30 1987-07-21 Strato Medical Corporation Infusion device
US20070233004A1 (en) * 2006-03-29 2007-10-04 The General Hospital Corporation D/B/A Massachusetts General Hospital Single-Dose Syringe Driver
CN103920211A (zh) * 2014-05-06 2014-07-16 深圳市尚荣医疗股份有限公司 一种高精度的微量注射泵及其应用
US20170087295A1 (en) * 2014-03-28 2017-03-30 Repro-Med Systems, Inc. Compact mechanical pump

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298000A (en) * 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4681566A (en) * 1984-11-30 1987-07-21 Strato Medical Corporation Infusion device
US20070233004A1 (en) * 2006-03-29 2007-10-04 The General Hospital Corporation D/B/A Massachusetts General Hospital Single-Dose Syringe Driver
US20170087295A1 (en) * 2014-03-28 2017-03-30 Repro-Med Systems, Inc. Compact mechanical pump
CN103920211A (zh) * 2014-05-06 2014-07-16 深圳市尚荣医疗股份有限公司 一种高精度的微量注射泵及其应用

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