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WO2025012889A1 - Composition liquide améliorant la qualité de vie - Google Patents

Composition liquide améliorant la qualité de vie Download PDF

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Publication number
WO2025012889A1
WO2025012889A1 PCT/ID2024/000007 ID2024000007W WO2025012889A1 WO 2025012889 A1 WO2025012889 A1 WO 2025012889A1 ID 2024000007 W ID2024000007 W ID 2024000007W WO 2025012889 A1 WO2025012889 A1 WO 2025012889A1
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WIPO (PCT)
Prior art keywords
nanobubble
nano
liquid composition
bubbles
hydrogen
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Pending
Application number
PCT/ID2024/000007
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English (en)
Inventor
Kan Eddy
Sutiman Bambang SUMITRO
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Individual
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Individual
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Definitions

  • This present invention generally relates to liquid compositions, and more specifically, this invention relates to a liquid composition for enhancing quality of life through a delivery system of functional gas in the form of nanobubbles.
  • Free radicals are molecules with unpaired electrons and exhibit high reactivity. They play a crucial role in several physiological processes, acting as mediators in intercellular communication systems to the immune system. These free radicals need to be regulated to function optimally in maintaining cell functions, protecting against infections, mediating the regulation of cellular communication quality, neural tissue functions, and overall maintaining the homeostasis of life systems.
  • the control of free radicals in the body is carried out by natural antioxidants in the form of enzyme systems or metabolite products such as hydrogen molecules, in addition to various complex compounds that are generally complex organic compounds. This control system regulates the amount of free radicals in alignment with normal physiological needs.
  • Oxidative stress can be caused by habits such as engaging in activities that do not align with the body’s biological clock, stress, and excessive consumption of chemical products like cosmetics, and food and drinks containing synthetic ingredients. Oxidative stress can lead to adverse effects such as premature aging and the pathological development of degenerative diseases like cancer, Alzheimer's, Parkinson's, atherosclerosis, and others.
  • SOD superoxide dismutase
  • GPx glutathione peroxidase
  • H2 hydrogen
  • I/R ischemia/reperfusion
  • H2 hydrogen
  • H2 has capabilities beyond reducing the accumulation of free radicals, such as enhancing the activity of antioxidant enzymes in wound tissue, thereby accelerating wound healing.
  • H2 also has the ability to suppress inflammation, regulate the body's immune system, and decrease apoptosis (cell death).
  • Hydrogen is an element abundantly found in the universe. In its normal state, hydrogen exists as a gas with a very light molecular weight. However, hydrogen has a very low solubility in water (Shafanov&Khitrin, 2013) and easily escapes from solutions. Therefore, to improve the stability and solubility of hydrogen, nano bubble technology is employed.
  • Hydrogen nano bubbles are smaller than 400 nm, which is below the average size of a cell.
  • the H2 molecules within the nano bubbles can remain stable for a long period, up to eight years of storage. Due to their high stability, hydrogen nano bubbles are extensively utilized in the health sector.
  • Research conducted by Kato et al. (2015) has shown that solutions containing hydrogen nano bubbles are more effective at neutralizing *OH free radicals than regular hydrogen solutions. Additionally, it has been reported that hydrogen nano bubbles are effective in reducing inflammation levels and suppressing adipogenesis (the formation of fat cells or tissues) (Li et al., 2020; Xiao & Miwa, 2021).
  • Hydrogen peroxide (H 2 O 2 ) is a molecule that is naturally produced in the body as a byproduct of oxygen metabolism. It is catalyzed by the enzymes peroxidase and catalase, which break down H 2 02into water and free oxygen ions. Hydrogen peroxide is a ubiquitous molecule and is abundant in nature (Halliwell et al., 2000). In 1888, H 2 O 2 was reported to have been used in therapies for healing diseases such as dengue fever, diphtheria, nasal mucosa inflammation, cough, asthma fever, and tonsillitis (Love, 1888). Hydrogen peroxide infusions were able to address influenza pneumonia epidemics following World War I (Oliver et al., 1920).
  • H 2 O 2 was considered a dangerous molecule to human body tissues. Although its use has sparked controversy in alternative medicine, H 2 O 2 is often regarded as a toxic molecule to various life systems. For instance, it can cause severe pathological conditions such as cancer, ischemia, and neurodegenerative diseases. Nevertheless, scientific evidence has reported a positive role of H 2 O 2 in biological processes, for example, in regulating the immune system to combat bacteria and viruses (Halliwell et al., 2000). The role of H 2 O 2 depends on its concentration within the cells. At low concentrations, H 2 O 2 can act as a signaling molecule to regulate cellular processes and survival.
  • cardiovascular system which consists of the heart, blood vessels, and blood.
  • the cardiovascular system is crucial for transporting nutrients and oxygen-rich blood to all body cells and returning deoxygenated blood back to the lungs. Any disruption in this system can lead to impaired transport processes, causing cells to suffer from a lack of nutrients and oxygen, which can eventually affect the performance of body organs. This impairment can decrease an individual's quality of life.
  • One factor that can disrupt the cardiovascular system is the presence of high cholesterol levels in the blood, typically resulting fromunhealthy dietary habits, such as consuming foods high in saturated fats and low in fiber. Additionally, lifestyle factors like insufficient physical activity also contribute to high cholesterol levels. Elevated blood cholesterol can lead to the formation of plaque along the walls of blood vessels.
  • LDL Low-Density Lipoproteins
  • This invention pertains to a liquid composition designed to enhance quality of life through a system for delivering functional gases in the form of nano bubbles.
  • This liquid composition is capable of improving the cardiovascular system in the human body, enabling it to function efficiently in delivering nutrient-rich and oxygenated blood to all body cells, while also returning deoxygenated blood back to the lungs.
  • the volume percentages of the liquid composition in accordance with this invention consist of 0.59%v-2.75%v nano bubble hydrogen (H 2 ), 0.29%v-l.37%v nano bubble oxygen (O 2 ), 0.39%v-0.55%v hydrogen peroxide (H 2 O 2 ), 0.00%v-l.83%v potassium chloride, and 91.66%v-98.33%v NaCl infusion fluid.
  • This invention employs a nano bubble delivery system containing functional gases such as H 2 , O 2 , CO, and H 2 S, with bubble sizes smaller than 400nm.
  • Functional gases are gases that have physiological roles beneficial to health.
  • the primary goal of this invention is to improve the quality of life. Smooth blood circulation throughout the body ensures adequate nutrition and oxygen supply to all cells, which in turn keeps body cells healthy and body organs functioning properly. Consequently, this slows down the aging process and extends human lifespan expectancy.
  • a notable benefit is that individuals over the age of 60 remain productive and independent .
  • Another aim of this invention is to enhance the quality of the cardiovascular system to restore its optimal function.
  • the liquid composition is directly injected into major blood vessels. From a hematological perspective, significant improvements include an increase in lymphocytes and monocytes and a decrease in granulocytes. This condition indicates that the injected liquid composition helps regulate the body's inflammatory state. Additional benefits of the composition include the reduction of triglycerides, cholesterol, LDL, and blood glucose levels.
  • a further objective is to reduce blood pressure.
  • Hydrogen molecules in the composition can decrease oxidative stress, thus providing an anti-hypertensive effect. Additionally, hydrogen molecules help correct neural imbalances by suppressing overactive sympathetic nervous system activities and enhancing the activity of the parasympathetic nervous system, which contributes to the blood pressure-lowering effect. Lowering blood pressure reduces the risk of stroke or heart disease.
  • Another goal of this invention is to enhance the flow through capillary vessels, the smallest blood vessels approximately 5 micrometers in diameter that connect arterial and venous blood vessels. Due to their small size, capillaries are more susceptible to blockages caused by plaque.
  • dissolved nano hydrogen bubbles in the infusion solution can enter capillary vessels, effectively clearing plaque and ensuring smooth blood flow.
  • the subsequent aim is to prevent or ameliorate neurodegeneration of nerve cells by inhibiting the aggregation of a-synuclein.
  • FIG 1 is a block diagram illustrating changes after 10 infusions in a Phase 2 clinical trial in accordance with this invention.
  • composition of the liquid in volume percentage according to this invention consists of:
  • the liquid composition according to this invention is administered into the body using a nano-bubble delivery system containing functional gas, consisting of:
  • Functional gas is a gas that has physiological functions, making it beneficial for health.
  • functional gas is encapsulated within nano-bubbles and mixed with a NaCl infusion solution.
  • nano-bubbles serve as a carrier medium for the functional gas into the body's cells.
  • Nano-bubbles are used in this invention due to their advantages over conventional bubbles and microbubbles. Their benefits include being less prone to breakage, enduring, stable, and remaining in water for an extended period (Yang & Chen, 2022). Unlike regular bubbles, which can expand, rise quickly to the surface and burst, and are unstable and disappear within seconds, microbubbles are more stable than conventional bubbles but can shrink and vanish or burst after a few minutes in water. Due to their very small size, nano-bubbles can easily enter blood vessels and surrounding cells.
  • nano-bubbles sized 100-200 nm contain H 2 gas ranging from 3.487xlCT 16 mL to 2.789xlCT 15 mL and O 2 gas ranging from 1.743xlCT 16 mL to 1.395xlCT 15 mL.
  • H 2 gas ranging from 3.487xlCT 16 mL to 2.789xlCT 15 mL
  • O 2 gas ranging from 1.743xlCT 16 mL to 1.395xlCT 15 mL.
  • nano-bubbles can encapsulate up to 15 mL of H 2 gas and 7.5 mL of O 2 gas.
  • each nano-bubble can only contain a maximum of 4.184xlCT 15 mL of H 2 and O 2 gas.
  • the maximum solubility of H 2 and O 2 gas in nano-bubbles in water is 4.5 mL per 100 mL of water, or 4.5%.
  • approximately 1.075xl0 15 nano-bubbles are required per lOOmL of water. From this data, it can be concluded that for 500mL of water, up to 5.375xl0 15 nano-bubbles containing H 2 and O 2 gas can be accommodated.
  • composition of the liquid in volume percentage according to this invention consists of:
  • the nano hydrogen bubbles used are characterized by being the smallest and lightest molecules in nature, which readily penetrate cells.
  • the utilization of these nano hydrogen bubbles provides an effect that: inhibiting aging or as an anti-aging agent,
  • hydrogen peroxide (H 2 O 2 ) in small quantities offers numerous benefits for the body.
  • the use of hydrogen peroxide (H 2 O 2 ) will provide effects which include: inhibiting viral and bacterial infections, supplying oxygen to tissues, regulating processes and cell survival.
  • nano oxygen bubbles are considered the most vital molecules for life due to their role in every cellular function.
  • the use of these nano oxygen bubbles also provides antibacterial effects and enhances energy.
  • MgSCq The next component in this liquid composition is MgSCq, which is known to improve the elasticity of blood vessels and maintain the health of nerve cells, heart rhythm, immune system, bones, and muscle function.
  • potassium Another key ingredient in this composition is potassium, which allows nerves to respond to stimuli and muscles to contract or tighten, including those in the heart. Additionally, potassium helps counteract the effects of sodium in raising blood pressure and facilitates the movement of nutrients into cells, as well as the expulsion of waste products from them.
  • potassium is not added to the composition of this liquid according to this invention if the individual receiving therapy has kidney issues. Conversely, for individuals without kidney problems, potassium is incorporated into the liquid composition for their treatment.
  • the inventor conducted a series of trials with this liquid composition as per the invention, starting with phase 1 animal trials using male Wistar rats as subjects.
  • phase 1 animal trials using male Wistar rats as subjects.
  • a safety study was conducted by comparing three groups of normal rats as follows:
  • HFD high-fat diet
  • the phase 1 trial was carried out by administering injections to rats as the experimental animal subjects.
  • Subsequent procedures included daily temperature measurements of the rats.
  • the next step involved surgical procedures on the rats, during which the liver organs were examined using a microscope with a 400x magnification.
  • the results of the safety testing of the injected fluid showed that the survival rate of the rats injected with this fluid was better compared to the control group (which received no treatment). Specifically, in the control group, some rats died, whereas in the group injected with the fluid, no deaths occurred. Further tests on the injected fluid in a group of hypercholesterolemic rats revealed that the fluid could reduce triglyceride and total cholesterol levels compared to the control. Additionally, it was found to increase HDL levels, but it did not significantly affect LDL levels. Meanwhile, the hypercholesterol group treated with simvastatin (a cholesterol- lowering drug) showed a decrease in cholesterol levels; however, the mortality rate in this group was high at 60%.
  • simvastatin a cholesterol- lowering drug
  • Stage 4 6-7 weeks after the administration of 3x hydrogen nanobubbles in the treatment group
  • Stage 5 7-8 weeks after the administration of 5x hydrogen nanobubbles in the treatment group.
  • phase 2 clinical trial was a randomized clinical trial approved by the ethics committee of the Politeknik Kesehatan Malang, under no. 41O/KEPK-POLKESMA/2022, and carried out at Dr.Benggol Hospital.
  • the trial involved 52 participants, including 8 randomly selected placebos, with age criteria of adults ( ⁇ 37 years). Participants received injections according to this composition, involving 10 infusion sessions followed by laboratory tests on blood samples and physical examinations. Additionally, participants completed the SF36 questionnaire, which covers general health, mental health, emotional limitations, vitality, body pain, and physical function.
  • Figure 1 shows a bar chart of changes after 10 infusion sessions in non-placebo participants. This chart displays the significance values for each test parameter.
  • Laboratory tests on participants' blood samples were conducted to gather data indicative of degenerative diseases.
  • the significance value was found to be 0.000. As this value is less than 0.05, it can be concluded that there is a significant difference between the levels before and after treatment.
  • the significance value was also 0.000, indicating a significant difference.
  • the significance value was 0.379, indicating no significant difference between the levels before and after treatment.
  • Doppler ultrasound examinations for vascular assessments related to Intima Media Thickness (IMT) revealed 11 cases where the carotid artery bulb thickness remained unchanged before and after treatment, while the remaining 32 cases remained normal, showing no overall change.
  • Doppler ultrasound examinations related to Flow-Mediated Dilation (FMD) indicated an increase in all cases to above 7.0 after treatment, signifying a decrease in arterial resistance and improved elasticity.
  • H 2 O 2 at low concentrations has insulin-like properties and plays a role in glucose transport activity in muscles (Henriksen, 2013). With its ability to lower cholesterol, triglycerides, and LDL, it can reduce the potential for degenerative diseases.
  • a variable that clearly shows improvement after administering this fluid infusion is a decrease in blood pressure. This is attributed to the reduction of oxidative stress by hydrogen molecules (Kawakami et al., 2022). Testing with mice has shown that hydrogen molecules provide an antihypertensive effect not only during daytime rest but also during nighttime activity. Moreover, hydrogen molecules can correct neural imbalances by suppressing an overly active sympathetic nervous system and enhancing the activity of the parasympathetic nervous system, which occurs concurrently with the blood pressure-lowering effect (Sugai et al., 2020). Based on the findings above, it can be concluded that this fluid infusion is safe for application, can provide positive effects for the cardiovascular system, and improve quality of life. Besides infusion injections, the composition can also be made into a drink, applied as a spray, or administered via injection.
  • liquid composition for enhancing quality of life in accordance with this invention may also consist o:
  • composition of the fluid there is a noticeable reduction of H 2 O 2 , but an addition of CO in the form of nano bubbles and H 2 S in the form of nano bubbles.
  • the function of the CO and H 2 S gases is to act as neurotransmitters for nerve communication.
  • the composition includes:

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une composition liquide pouvant améliorer le système cardiovasculaire dans le corps humain. Elle permet au système cardiovasculaire de transporter efficacement des nutriments et du sang riche en oxygène vers toutes les cellules du corps, ainsi que de transporter le sang désoxygéné vers les poumons. La composition contient des des composants de nano-bulles d'hydrogène qui procurent des effets antivieillissement, l'inhibition des radicaux libres, la prévention de la mort cellulaire et des avantages anti-inflammatoires. De plus, elle comprend des composants de peroxyde d'hydrogène (H2O2) qui aident à inhiber les infections virales et bactériennes, à fournir de l'oxygène aux tissus, et à réguler les processus et la viabilité cellulaires.
PCT/ID2024/000007 2023-07-13 2024-07-03 Composition liquide améliorant la qualité de vie Pending WO2025012889A1 (fr)

Applications Claiming Priority (2)

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IDP00202306325 2023-07-13
IDP00202306325 2023-07-13

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2372082C2 (ru) * 2007-07-23 2009-11-10 Владимир Андреевич Миронов Способ оздоровления организма при заболеваниях сердечно-сосудистой и нервной системы
WO2011139478A2 (fr) * 2010-04-30 2011-11-10 H R D Corporation Application à cisaillement élevé utilisée dans une thérapie médicale
US20190046563A1 (en) * 2013-12-27 2019-02-14 Aqua Zest Corporation Nanobubble-containing composition and use thereof
JP6828918B1 (ja) * 2019-10-30 2021-02-10 浩平 池田 心停止後の自己心拍再開後の生存率改善剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2372082C2 (ru) * 2007-07-23 2009-11-10 Владимир Андреевич Миронов Способ оздоровления организма при заболеваниях сердечно-сосудистой и нервной системы
WO2011139478A2 (fr) * 2010-04-30 2011-11-10 H R D Corporation Application à cisaillement élevé utilisée dans une thérapie médicale
US20190046563A1 (en) * 2013-12-27 2019-02-14 Aqua Zest Corporation Nanobubble-containing composition and use thereof
JP6828918B1 (ja) * 2019-10-30 2021-02-10 浩平 池田 心停止後の自己心拍再開後の生存率改善剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Hydrogen Peroxide IV Drip", RECOVERY ROOM, 1 January 2022 (2022-01-01), XP093267710, Retrieved from the Internet <URL:https://www.recoveryroomaz.com/vitamin-iv-drips/hydrogen-peroxide-iv-drip-therapy-recovery-room-scottdale-az> *
MATTHEW A. HICKS; ALKA TYAGI: "Magnesium Sulfate", MAGNESIUM SULFATE, STATPEARLS PUBLISHING, US, US, XP009561465, Retrieved from the Internet <URL:http://web.archive.org/web/20230224130119/https:/www.ncbi.nlm.nih.gov/books/NBK554553/> [retrieved on 20241007] *

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