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WO2025006306A1 - Systèmes et procédés de lyophilisation - Google Patents

Systèmes et procédés de lyophilisation Download PDF

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Publication number
WO2025006306A1
WO2025006306A1 PCT/US2024/034712 US2024034712W WO2025006306A1 WO 2025006306 A1 WO2025006306 A1 WO 2025006306A1 US 2024034712 W US2024034712 W US 2024034712W WO 2025006306 A1 WO2025006306 A1 WO 2025006306A1
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WO
WIPO (PCT)
Prior art keywords
freeze
process chamber
drying
electromagnetic field
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/034712
Other languages
English (en)
Inventor
Dimitrios Peroulis
Alina ALEXEENKO-PEROULIS
Andrew David Strongrich
Ahmad Naif DARWISH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of WO2025006306A1 publication Critical patent/WO2025006306A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/14—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects using gases or vapours other than air or steam, e.g. inert gases
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/005—Treatment of dryer exhaust gases
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/18—Drying solid materials or objects by processes involving the application of heat by conduction, i.e. the heat is conveyed from the heat source, e.g. gas flame, to the materials or objects to be dried by direct contact
    • F26B3/20—Drying solid materials or objects by processes involving the application of heat by conduction, i.e. the heat is conveyed from the heat source, e.g. gas flame, to the materials or objects to be dried by direct contact the heat source being a heated surface, e.g. a moving belt or conveyor
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/32—Drying solid materials or objects by processes involving the application of heat by development of heat within the materials or objects to be dried, e.g. by fermentation or other microbiological action
    • F26B3/34—Drying solid materials or objects by processes involving the application of heat by development of heat within the materials or objects to be dried, e.g. by fermentation or other microbiological action by using electrical effects
    • F26B3/347—Electromagnetic heating, e.g. induction heating or heating using microwave energy
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/044—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum for drying materials in a batch operation in an enclosure having a plurality of shelves which may be heated
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/048—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum in combination with heat developed by electro-magnetic means, e.g. microwave energy

Definitions

  • the invention generally relates to systems, components, and/or processes for freeze-drying items using electromagnetic energy, and, in some nonlimiting embodiments, to freeze-drying biopharmaceutical products.
  • Freeze-drying (also referred to as lyophilization) is a process of removing water from a material and has been used to preserve perishable materials, extend shelf life, and/or make a material more convenient for transport. Freeze-drying works by freezing the material, then reducing the pressure and adding heat to allow the frozen water in the material to sublimate. A benefit of freeze-drying is that it can reduce drying times of the material by up to 30% over other conventional drying processes, such as passive or active air and/or thermal drying processes.
  • conventional freeze-drying methods include three phases.
  • the first phase the freezing phase
  • this initial freezing phase is accomplished rapidly to prevent cell wall damage caused by large ice crystals that form during slower freezing processes.
  • the second phase the primary drying (sublimation) phase
  • the primary drying (sublimation) phase the pressure in and around the material is reduced and the product is warmed slightly to sublimate the ice (frozen water) in the material, yielding water vapor.
  • This phase typically removes about 95% of the frozen water.
  • the third phase the secondary drying (adsorption) phase
  • ionically-bound water molecules are removed from the material by raising the temperature further above that in the sublimation phase while maintaining a vacuum.
  • Freeze-drying can be used to stabilize biomaterials, including but not limited to highly sensitive pharmaceutical drugs and biological products, prior to long-term storage. Freeze-drying of biologic materials, such as biopharmaceuticals, has gained significant interest in recent years due to the high demand for product stabilization, and has become widely used in the pharmaceutical industry because it permits the processing of thermolabile products in sterile conditions. Further, there is rising demand for lyophilized injectable medicines and molecular diagnostics. Unfortunately, freeze-drying is a very time-consuming industrial processes with a relatively low energy efficiency typically of less than 10%.
  • RF chamber metallic Faraday chamber
  • radiator radiator
  • the present invention provides, but is not limited to, freeze-drying systems and methods of freeze-drying products, including biomaterials.
  • a freeze-drying system includes a process chamber configured for freeze-drying a product, and a phased array RF system configured to emit electromagnetic waves into the process chamber via an antenna array to form an electromagnetic field in the process chamber having an electromagnetic field distribution.
  • the phased array RF system is configured to vary the electromagnetic field distribution in the chamber.
  • a method of freeze-drying a product includes maintaining a product in a frozen condition inside a process chamber, lowering the pressure of the process chamber to induce sublimation of a frozen solvent of the product, heating the product during the sublimation with an electromagnetic field formed by electromagnetic waves emitted from an antenna array, and varying the electromagnetic field distribution inside the process chamber over time during the sublimation.
  • Technical aspects of systems and methods as described above preferably include the ability to reduce the time needed to freeze-dry products, such as biomaterials, improve energy efficiency during freeze-drying, reduce damage to cells in biomaterials that are being freeze-dried, and/or improve effectiveness of a biomaterial freeze-drying process.
  • FIG. l is a schematic diagram of a freeze-drying system according to a nonlimiting embodiment of the invention.
  • FIG. 2 is a schematic diagram of a phased array RF system capable of beam forming in the system of FIG. 1.
  • freeze-drying system 10 shown in the drawings and described as used to freeze-dry biologic materials (biomaterials), and particularly biopharmaceuticals.
  • teachings of the invention are more generally applicable to a variety of types of freeze-drying systems and can be used for freeze-drying many other types of materials.
  • FIG. 1 schematically illustrates the freeze-drying system 10.
  • the system 10 its components and associated methods, addresses one or more of the above-discussed limitations by applying high-frequency (e.g., 8 GHz to 18 GHz) electromagnetic waves that volumetrically heat the products as they dry.
  • the system and method are preferably capable of significantly reducing the drying time relative to conventional lyophilization while simultaneously improving overall heating uniformity among the product locations.
  • the system and method are capable of drying biologic material samples twice as fast as conventional freeze-drying systems and methods.
  • the nonlimiting embodiment of the freeze-drying system 10 represented in FIG. 1 includes a process chamber 12 and a condenser chamber 14.
  • the process chamber 12 has an interior cavity in which material (“product") 60 to be freeze-dried is placed during the freeze- drying process.
  • the condenser chamber 14 has an interior cavity in which vapors that sublime during the freeze-drying process can be trapped and a ballast gas utilized during the freeze- drying process can be removed.
  • the product 60 is represented as being contained in multiple vials, though various other means of containing the product 60 are foreseeable and well known in the art, as nonlimiting examples, trays, medical devices, foams, tissue, food, etc.
  • the process chamber 12 may have an RF resistant layer, such as a Faraday cage, surrounding the interior cavity to prevent electromagnetic energy from escaping from the interior cavity.
  • a duct 16 operatively couples the process chamber 12 with the condenser chamber 14 to allow gas within the cavity of the process chamber 12 to flow into the condensing chamber 14, and an isolation valve 18 is provided within the duct 16 to regulate gas flow between the chambers 12 and 14.
  • the isolation valve 18 may be selectively opened to allow gas flow between the chambers 12 and 14 or closed to prevent or at least inhibit gas flow between the chambers 12 and 14. As such, when closed the isolation valve 18 is able to separate and optionally seal the process chamber 12 where the product 60 is dried from the condenser 14 where sublimed vapors are trapped and a ballast gas is removed.
  • a phased array RF system 20 is operatively coupled to the process chamber 12 so as to be able to emit electromagnetic energy (also referred to herein as beam forming) into the process chamber 12 as described in more detail hereinafter.
  • the RF system 20 generates high- frequency, high-power electromagnetic (RF) waves that are injected into the process chamber 12.
  • the system 20 includes an antenna array 22 of individual antennas that direct focused RF energy inside the process chamber 12 of the freeze-drying system 10.
  • the antenna array 22 may also generate non-focused RF energy as well.
  • the RF system 20 emits RF signals, referred to as “beams” 21 herein, that have a random (or pseudo-random) change of the phases from the antenna array 22.
  • the generated RF beams 21 result in the formation of different and varying electromagnetic field distributions inside the process chamber 12. Such a change in the distribution of the electromagnetic field is attributed to the change of the coefficients associated with the different excited modes. In this way, the variation of the phases of the RF beams 21 emitted from different antennas of the antenna array 22 can cause both in-phase excitation as well as out-of-phase excitation of the product 60 inside the process chamber 12.
  • the phased array RF system 20 is represented in FIG. 1 as completely externally connected outside of the process chamber 12; however, in other configurations it can be disposed completely or partially inside the process chamber 12, depending on the utilized application.
  • the phased array RF system 20 may be mounted to an external side of a door 26 to the chamber 12 through which vials of the product 60 are inserted and removed.
  • both the antenna array 22 and the remaining components of the system 20 are disposed outside of the process chamber 12.
  • the RF system 20 could be mounted inside the process chamber 12 due to its relatively small size and portability.
  • phased array RF system 20 may be mounted or otherwise located outside of the process chamber 12 and other components of the phased array RF system 20 may be partially or completely located outside the process chamber 12.
  • the antenna array 22 may at least partially extended to the inside of the process chamber 12, or even be completely located therein, and other components of the phased array RF system 20, such as oscillators, amplifiers, splitters, phase shifters, couplers, and/or circulators, may be mounted to the outside of the process chamber 12 or otherwise disposed outside of the process chamber 12.
  • suitable RF shielding may be provided and configured to prevent RF energy from escaping the process chamber 12.
  • RF shielding may include, for example, a metallic coating on the door 26 and/or a separate metallic mesh attached to the door 26.
  • One or more shelves 24 may be disposed inside the process chamber 12, for example, on which product 60 that is to be freeze-dried may be placed during the freeze-drying process.
  • the shelves 24 are preferably temperature controlled to be able to cool (e.g., freeze) and/or heat any products 60 disposed on the shelves 24.
  • the shelves 24 may have heating and/or cooling units associated therewith so that the temperatures of the shelves 24 themselves can be decreased or increased to correspondingly cool or heat products 60 disposed thereon. Any cooling and/or heating units capable of providing the necessary cooling/heating may be used.
  • a viewport 28 such as a small glass-covered window, may be provided in the door 26 to allow for visual (or IR) inspection of the products 60 during freeze-drying.
  • a shielding metallic mesh or coating may also cover the viewport 28 to prevent or minimize any RF leakage that might occur through the viewport 28.
  • the size of the mesh may be chosen to ensure that visual inspection is possible through the viewport 28 into the process chamber 12 while also keeping the RF energy stored inside the chamber 12.
  • FIG. 12 represents an inlet duct 30 through a wall of the process chamber 12 to allow a ballast gas 62 to be injected into the process chamber 12.
  • the ballast gas 62 is typically a non-condensable and/or inert gas that is introduced into the process chamber 12 to regulate pressure around a user-defined setpoint.
  • An example of a typical ballast gas is nitrogen gas.
  • a vacuum pump 32 is operatively coupled to the condenser chamber 14 to draw a vacuum from the condenser chamber 14. The vacuum pump 32 can also draw a vacuum from the process chamber 12 when the isolation valve 18 is open.
  • a second vacuum pump 36 may be operatively coupled to the process chamber 12 to directly draw a vacuum from the cavity inside the process chamber 12, for example, when the isolation valve 18 is closed.
  • One or more vacuum sensors and/or gauges 34 are represented as operatively coupled with the interior cavity of the process chamber 12 to measure vacuum pressure inside the cavity and to provide any data feedback to the freeze-drying system 10 necessary to regulate pressure inside the cavity around a user-defined setpoint.
  • FIG. 2 shows additional details of a nonlimiting embodiment of the RF system 20.
  • the system 20 is represented as including a local oscillator 40, amplifiers 42, 44, and 46, an RF splitter 48, phase shifters 50, directionals couplers 52, and circulators 54.
  • components of the RF system 20 are assembled as a single unit, for example, within and/or on a single support such as a housing 23, that can be easily mounted to a single support surface, such as the door 26 or an interior wall of the process chamber 12.
  • the antenna array 22 could be assembled as part of the single unit to mount with the housing 23 or the antenna array 22 could be separate or separable from the housing 23 so it can be mounted remote from the housing 23.
  • the RF system 20 may also include a controller 56 configured to execute field mixing algorithms for varying the RF beams 21 as disclosed herein.
  • the controller 56 may, for example, an on-board central processing unit (CPU) configured with appropriate software instructions and/or hardware components or other digital and/or analog system configured to execute the RF field mixing algorithms for changing the phases of the RF beams 21 emitted by the antenna array 22 to randomly or pseudo-randomly or otherwise vary the RF field within the process chamber 12 over time as described herein.
  • CPU central processing unit
  • the controller 56 could be located remote from or have at least some components located remote from the system 20.
  • the antenna array 22 is a 3 X 1 antenna array, and the controller 56 is configured to change the relative phases of individual antennas of the array 22 relative to each other over time to change the structure of their respective beams 21, thereby resulting in different varying electromagnetic RF field distributions inside the process chamber 12 that change over time.
  • the local oscillator 40 generates a low-power, high-frequency RF signal.
  • One possible local oscillator is a voltage-controlled oscillator (VCO), which takes electrical voltage as an input and outputs an RF signal. Because the RF signal generated by the VCO is usually low power, the low-noise amplifier 42 is provided to increase the power of the RF signal output from the local oscillator 40 before it is divided into different paths. The output of the low-noise amplifier 42 goes into the RF splitter 48 that functions as a power divider to divide the RF signals into a preselected number (e.g., “n”) separate RF signals.
  • VCO voltage-controlled oscillator
  • the RF splitter 48 splits the incoming RF signal into a number of different RF signals that correspond with the number of antennas in the antenna array 22.
  • the RF splitter 48 splits the amplified RF signal from the low-noise amplifier 42 into three separate RF signals, one signal to correspond to each of the three antennas in the antenna array 22.
  • fewer or more separate signals could be generated if fewer or more antennas are provided in the antenna array 22. Because each signal output from the RF splitter 48 is again at a lower power, the separate signals from the RF splitter 48 are fed through another set of power amplifiers 44 to increase the power of the split RF signals.
  • the separate RF signals from the power amplifiers 44 are directed to the phase shifters 50 to control the phases of the different RF signals.
  • at least two phase shifters are used in order to be able to separately shift the phases of at least two RF signal streams so that they can be at different phases from each other.
  • a different phase shifter 50 is provided for each signal stream emitted from the RF splitter 48. The phase shifters 50 make it possible to change the radiation pattern of the antenna array 22, thereby generating a desired RF radiation pattern.
  • phase shifters 50 are lossy (they reduce the power of the RF signals)
  • the output phase shifted RF signals are fed into a final amplification stage at the power amplifiers 46, such as GaN power amplifiers, before being fed to the antenna array 22.
  • the phase-shifted and re-amplified RF signals from the third power amplifiers 46 are directed through one or more circulators 54 operatively disposed between the antennas 22 and the power amplifiers 46.
  • FIG. 2 represents one or more directional couplers 52 and/or signal detectors 58 may be provided for monitoring the output power from the phase shifters 50.
  • the phased-array RF system 20 may be a self-contained "bolt-on" unit configured to be installed on most commercial lyophilizers with minimal modification.
  • the self-contained "bolt-on” unit interfaces with a client computer and/or other control devices, allowing basic operating parameters such as frequency, output power, azimuth, and zenith angle to be controlled by the user.
  • the configuration of the system 20 shown in FIG. 2 is just one possible example of how to generate high power RF beams 21 for use with the freeze-drying system 10.
  • the beams 21 may be generated in various other manners and/or by other configurations of components.
  • the primary factor that determines a desired configuration for the RF system 20 is the choice of components and their corresponding operating conditions and electrical specifications.
  • freeze-drying system 10 may perform freeze-drying through various operations. Some of the following operations may change depending on the particular implementation and/or material being freeze-dried, such as the product 60 represented in FIG. 1.
  • the product 60 to be dried is loaded into the process chamber 12, such as onto the temperature-controlled shelves 24.
  • the product 60 and/or its container may include liquid- filled vials or trays, medical devices, foams, tissue, food, etc.
  • the product 60 may be frozen prior to loading and the shelves 24 are cooled to a user-defined temperature prior to loading.
  • the product 60 being dried includes a mixture of solvent and solute disposed in vials that are loaded onto the shelves 24.
  • the solvent may be any liquid within which a solid solute is mixed.
  • the solvent may include or be water, a biological solvent, an organic solvent, an inorganic solvent, or any other liquid solvent that can be frozen from its liquid form to a solid form.
  • the process chamber 12 is then sealed, for example by closing the door 26 and/or closing the isolation valve 18, and the temperatures of the shelves 24 are lowered until the product 60 freezes and/or otherwise reaches a target temperature.
  • This primary freezing step separates the solvent from the solute and provides a stable solid matrix in preparation for primary drying (sublimation phase).
  • the pressure inside of the process chamber 12 is lowered, for example using the vacuum pump 36, during a primary drying/sublimation phase.
  • the pressure inside the process chamber 12 is reduced to be low enough to induce sublimation of the frozen solvent inside the vials containing the product 60 in the process chamber 12.
  • the isolation valve 18 is open to allow sublimated moisture from the product 60 within the vials to flow through the duct 16 and into the condenser chamber 14, where a condenser 38 condenses the sublimated moisture.
  • the RF system 20 While the pressure is reduced during the primary drying phase, the RF system 20 is activated, and the antenna array 22 radiates electromagnetic energy in the form of RF beams (signals) 21 into the process chamber 12, which adds heat into the process chamber 12.
  • the added heat from the electromagnetic energy offsets latent heat lost through sublimation. Additional heat may also be supplied by the shelves 24, for example, with a heating unit.
  • An inert and non-condensable ballast gas 62 such as nitrogen, is also introduced into the process chamber 12 to regulate the pressure inside the chamber 12 to be at or around a user-defined setpoint.
  • the vacuum sensors and/or gauges 34 can provide feedback to a control system (e.g., the controller 56) to perform this operation.
  • the ballast gas 62 bypasses the condenser 38 and is removed by the vacuum pump 32.
  • the sublimed solvent vapor flows out of the vials, through the duct 16, and into the condenser chamber 14.
  • the condenser 38 is maintained at a very low temperature sufficient to condense the solvent vapor onto its surface.
  • the freeze-drying system 10 may have an additional pump 37 to remove the condensate formed by vapors condensed by the condenser 38.
  • the primary drying (sublimation) phase is typically the longest phase of the freeze-drying process and can take anywhere from days to weeks to successfully complete.
  • the temperature of the resulting partially dry matrix is raised and maintained at a user-defined value in order to desorb remaining bound water or other liquid within the product 60.
  • This operation is known as the secondary drying phase, and heating provided during this phase may be accomplished by either or both the shelves 24 and the RF system 20.
  • the RF system 20 is deactivated and the product 60 is typically sealed inside of the sterile environment of the process chamber 12. Thereafter, the pressure inside the process chamber 12 can be restored to atmosphere, and the product 60 can be removed from the process chamber 12 for further processing as desired.
  • freeze-drying system 10 from previously known systems is that that the system 10 and freeze-drying process do not require any mechanical stirrers and/or scatterers inside the process chamber 12. Rather, the system 10 implements an “electronic” stirring of an electromagnetic field by means of the beams 21 generated by the system 20 randomly varying the electromagnetic field inside the process chamber 12.
  • the freeze-drying system 10 and associated method are preferably capable of providing several technical advancements over conventional approaches. For example, unlike previously known RF-assisted freeze-drying systems, the freeze-drying system 10 does not need an RF box or mechanical stirrers found in conventional approaches.
  • the system 10 and methods described herein replace the mechanical stirrers of conventional RF- assisted systems with the RF system 20, which improves the electromagnetic field homogeneity in and around the drying product 60 while taking up less or no space inside the freeze-dryer process chamber 12 compared with conventional mechanical stirrers.
  • the RF system 20 may be affixed to a metallic door, or some other portion, of a freeze-dryer due to its compact size. The absence of an RF Box allows for, among other advantages, the stoppering of the product- filled vials at the end of the cycle.
  • freeze-drying system 10 and its components could differ in appearance and construction from the embodiments described herein and shown in the drawings, functions of certain components of the freeze-drying system could be performed by components of different construction but capable of a similar (though not necessarily equivalent) function, and various materials could be used in the fabrication of the freeze-drying system and/or its components.
  • functions of certain components of the freeze-drying system could be performed by components of different construction but capable of a similar (though not necessarily equivalent) function
  • various materials could be used in the fabrication of the freeze-drying system and/or its components.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Drying Of Solid Materials (AREA)

Abstract

L'invention concerne des systèmes et des procédés de lyophilisation. Un tel système comprend un système RF à réseau à commande de phase configuré pour émettre des ondes électromagnétiques dans une chambre de traitement par l'intermédiaire d'un réseau d'antennes pour former un champ électromagnétique dans la chambre de traitement. Le système RF à réseau à commande de phase fait varier la distribution de champ électromagnétique dans la chambre, par exemple, par variation aléatoire dans le temps d'un déphasage entre deux signaux RF séparés ou plus émis dans la chambre de traitement à partir d'antennes séparées du réseau d'antennes.
PCT/US2024/034712 2023-06-30 2024-06-20 Systèmes et procédés de lyophilisation Pending WO2025006306A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363524382P 2023-06-30 2023-06-30
US63/524,382 2023-06-30

Publications (1)

Publication Number Publication Date
WO2025006306A1 true WO2025006306A1 (fr) 2025-01-02

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050793A1 (en) * 2004-07-30 2008-02-28 Durance Timothy D Method of drying biological material
US20180249855A1 (en) * 2017-03-06 2018-09-06 Illinois Tool Works Inc. Modified s-parameter measurement and usage in solid state rf oven electronics
US20210041169A1 (en) * 2019-08-10 2021-02-11 Purdue Research Foundation Rf-heating in industrial metallic chambers
KR20210122753A (ko) * 2020-11-30 2021-10-12 김형석 건조 장치
WO2022109384A1 (fr) * 2020-11-20 2022-05-27 Drymax Ddg Llc Élimination d'humidité par radiofréquence

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050793A1 (en) * 2004-07-30 2008-02-28 Durance Timothy D Method of drying biological material
US20180249855A1 (en) * 2017-03-06 2018-09-06 Illinois Tool Works Inc. Modified s-parameter measurement and usage in solid state rf oven electronics
US20210041169A1 (en) * 2019-08-10 2021-02-11 Purdue Research Foundation Rf-heating in industrial metallic chambers
WO2022109384A1 (fr) * 2020-11-20 2022-05-27 Drymax Ddg Llc Élimination d'humidité par radiofréquence
KR20210122753A (ko) * 2020-11-30 2021-10-12 김형석 건조 장치

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