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WO2025005316A1 - Dispositif de sonde ultrasonore-optique combinées - Google Patents

Dispositif de sonde ultrasonore-optique combinées Download PDF

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Publication number
WO2025005316A1
WO2025005316A1 PCT/KR2023/008929 KR2023008929W WO2025005316A1 WO 2025005316 A1 WO2025005316 A1 WO 2025005316A1 KR 2023008929 W KR2023008929 W KR 2023008929W WO 2025005316 A1 WO2025005316 A1 WO 2025005316A1
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Prior art keywords
light source
light
piezoelectric body
source unit
ultrasonic
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English (en)
Korean (ko)
Inventor
이상구
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Ibule Photonics Co Ltd
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Ibule Photonics Co Ltd
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Priority claimed from KR1020230082018A external-priority patent/KR102904524B1/ko
Application filed by Ibule Photonics Co Ltd filed Critical Ibule Photonics Co Ltd
Publication of WO2025005316A1 publication Critical patent/WO2025005316A1/fr
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0625—Warming the body, e.g. hyperthermia treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0034—Skin treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging

Definitions

  • the present invention relates to an ultrasound-optical fusion probe device.
  • Ultrasound stimulation therapy which can stimulate the affected area without physical invasion, is widely used.
  • Ultrasound is divided into high-intensity focused ultrasound (HIFU) and low-intensity focused ultrasound (LIFU) depending on its intensity.
  • High-intensity focused ultrasound is used for direct treatment to physically remove living tissues such as cancer cells, tumors, and lesions, while low-intensity focused ultrasound is known to obtain medical effects without necrosis of living tissues.
  • high-intensity focused ultrasound can be used to noninvasively remove lesions
  • low-intensity focused ultrasound can be used to noninvasively treat neurological disorders such as cognitive impairment, anxiety, and depression.
  • These ultrasound treatment devices are equipped with an ultrasound probe (ultrasound transducer) for transmitting and receiving diagnostic ultrasound signals to obtain ultrasound images of the subject, and for transmitting therapeutic ultrasound signals to the affected area to be treated.
  • An object of one aspect of the present invention is to provide an ultrasonic probe structure capable of securing high output (High Acoustic Power) characteristics while reducing the size by improving the physical characteristics compared to conventional ultrasonic probes, and to provide an ultrasonic-optical fusion probe device capable of maximizing the treatment effect by simultaneously applying an ultrasonic treatment method using a piezoelectric body and a photothermal treatment method using a light source.
  • An ultrasound-optical fusion probe device is characterized by including: a light source unit that irradiates light; a piezoelectric body configured to transmit light irradiated by the light source unit, wherein a transmission direction of an ultrasonic signal generated by the piezoelectric body and a direction of light irradiation from the light source unit are configured in the same direction; and first and second conductive members arranged on first and second surfaces of the piezoelectric body, respectively, in such a way that overlap between the transmission direction of the ultrasonic signal and the direction of light irradiation is avoided.
  • the transmission direction of the ultrasonic signal, the light irradiation direction, and the electric field application direction through the first and second conductive members are characterized in that they are perpendicular.
  • the light source unit and the piezoelectric body are characterized in that they are aligned along the first direction.
  • the present invention further includes a rear layer; and the light source unit, the rear layer, and the piezoelectric body are sequentially aligned and arranged along the first direction, so that the rear layer, together with the piezoelectric body, forms a light irradiation path from the light source unit.
  • the present invention further includes a control unit that controls transmission of an ultrasonic signal by the piezoelectric body and irradiation of light by the light source unit, and the control unit is characterized in that it selectively performs an ultrasonic treatment operation by the piezoelectric body and a photothermal treatment operation by the light source unit in a treatment mode for a target area to be treated.
  • the control unit when performing both the ultrasonic treatment operation and the photothermal treatment operation in the treatment mode, is characterized in that it at least partially overlaps a first time period during which the ultrasonic treatment operation is performed and a second time period during which the photothermal treatment operation is performed, or provides a time difference of a range less than a preset gap between the first time period and the second time period.
  • the light source unit includes a first light source that irradiates first light of a first wavelength band and a second light source that irradiates second light of a second wavelength band different from the first wavelength band, and in the photothermal treatment operation process, the control unit is characterized in that it controls the light source unit in a manner of activating the first and second light sources simultaneously or in a manner of activating the first and second light sources sequentially.
  • the treatment mode is divided into a plurality of treatment modes depending on the disease to be treated, and the frequency of the ultrasonic signal in each treatment mode is configured to be variable.
  • the element stacking direction of the ultrasonic probe, the electric field application direction to the piezoelectric body, and the polarization direction of the piezoelectric body are configured to have a predefined relationship profile (a perpendicular profile of the electric field application direction and the polarization direction with respect to the stacking direction), thereby improving physical properties such as the mechanical quality factor (Q m ) and the coercive electric field (E C ), thereby securing the high acoustic power characteristics of the ultrasonic probe.
  • the treatment effect on the affected area e.g., bone joint or skin
  • the treatment effect on the affected area can be maximized by simultaneously applying ultrasonic treatment by the ultrasonic probe and photothermal treatment by the light source unit, and by adopting a structure in which the ultrasonic probe and the light source unit are aligned according to the transmission direction of the ultrasonic signal and light, the size of the entire probe device can be reduced.
  • the first and second conductive members are arranged on the side surfaces of the piezoelectric body by the above-described relationship profile, the light irradiated from the light source unit and the first and second conductive members do not overlap each other, and therefore, when the first and second conductive members are arranged on the upper and lower surfaces of the piezoelectric body, the dependence on the transparent material of the conductive member required is eliminated, and thus the degree of freedom in design and implementation of the conductive member can be improved.
  • Figure 1 is an exemplary diagram showing the structure of an ultrasonic probe array in an ultrasonic-optical fusion probe device of the present embodiment.
  • Figure 2 is an exemplary diagram showing the structure of a probe unit in the ultrasonic-optical fusion probe device of the present embodiment.
  • Figure 3 is an exemplary diagram for explaining a relationship profile in the ultrasound-optical fusion probe device of the present embodiment.
  • Figure 4 is an exemplary diagram showing the arrangement structure of the probe unit and the light source unit in the ultrasonic-optical fusion probe device of the present embodiment.
  • Figure 5 is a block diagram for functionally explaining the ultrasound-optical fusion probe device of the present embodiment.
  • Figure 6 is an exemplary diagram showing a time-series configuration in which ultrasound treatment operation and photothermal treatment operation are performed in the ultrasound-optical fusion probe device of the present embodiment.
  • FIG. 1 is an exemplary diagram showing the structure of an ultrasound probe array in an ultrasound-optical fusion probe device of the present embodiment
  • FIG. 2 is an exemplary diagram showing the structure of a probe unit in an ultrasound-optical fusion probe device of the present embodiment
  • FIG. 3 is an exemplary diagram for explaining a relationship profile in an ultrasound-optical fusion probe device of the present embodiment
  • FIG. 4 is an exemplary diagram for explaining the arrangement structure of a probe unit and a light source unit in an ultrasound-optical fusion probe device of the present embodiment
  • FIG. 5 is a block diagram for functionally explaining the ultrasound-optical fusion probe device of the present embodiment
  • FIG. 6 is an exemplary diagram showing a time-series configuration in which an ultrasound treatment operation and a photothermal treatment operation are performed in the ultrasound-optical fusion probe device of the present embodiment.
  • the ultrasound-optical fusion probe device (1) of the present embodiment (hereinafter, referred to as the device) is implemented with an array structure in which a plurality of probe units (PUs) are sequentially arranged, and can be implemented with a one-dimensional (1D) or two-dimensional (2D) array structure (FIG. 1 shows an example of an implementation of a two-dimensional (8X8) array structure).
  • Each probe unit (PU) is partitioned by a kerf (K), and the kerf (K) can correspond to a gap (Gap) formed between each probe unit (PU).
  • the structure illustrated in FIG. 1 and the light source unit (50) described below correspond to an array structure that can be applied to the inside of the device (1), and can be fixedly installed inside the device (1) through a predetermined mounting member and frame.
  • the structure and relationship profile of the probe unit (PU) employed in this embodiment will be first described, and then the arrangement structure of the probe unit and light source unit (50), and the ultrasonic treatment operation and photothermal treatment operation will be described.
  • the probe unit (PU) in the present embodiment is defined as a structure including a back layer (10), a piezoelectric body (20), a matching layer (30), and first and second conductive members (41, 42) arranged on first and second surfaces of the piezoelectric body (20), which are sequentially laminated in the axial direction (A) (as described below, the back layer (10) may be omitted depending on the embodiment).
  • the terms 'upper' and 'lower' indicated below are described as referring to the axial direction (A) of the device (1), and the 'side' is described as referring to the lateral direction (L) or elevation direction (E) of the device (1).
  • the backing layer (10) is arranged below the piezoelectric body (20) described below, and absorbs and attenuates ultrasonic signals generated from the piezoelectric body (20) and propagating downward, thereby blocking the ultrasonic signals from propagating downwardly of the piezoelectric body (20), thereby preventing image distortion.
  • the backing layer (10) may have an acoustic impedance lower than that of the piezoelectric body (20), and may be composed of a material having an acoustic impedance of, for example, 2MRayl to 5MRayl.
  • the backing layer (10) may be manufactured into a plurality of layers in order to improve the attenuation or blocking effect of the ultrasonic signal.
  • the backing layer (10) may be omitted within a range in which the attenuation characteristics and impedance matching characteristics of the ultrasonic signal are secured at the level of the present device (1).
  • the back layer (10) forms a light irradiation path from a light source unit (50) described later, and for this purpose, the back layer (10) may be implemented with a light-transmitting material (e.g., transparent epoxy or glass material).
  • the piezoelectric material (20) When diagnosing a target object, the piezoelectric material (20) mechanically vibrates in response to an electrical signal applied thereto through the first and second conductive members (41, 42) described below, thereby generating a diagnostic ultrasonic signal and transmitting the same to the target object (e.g., a body or a tissue within the body), and receives an ultrasonic signal reflected from a specific part within the target object and converts it into an electrical signal.
  • the piezoelectric material (20) when treating a target area of the target object, the piezoelectric material (20) mechanically vibrates in response to an electrical signal applied thereto through the first and second conductive members (41, 42), thereby generating a therapeutic ultrasonic signal.
  • the present embodiment focuses on treating a target area of the target object.
  • the piezoelectric body (20) can be implemented with a piezoelectric single crystal material. Specifically, the piezoelectric body (20) can be implemented with any one of a first-generation single crystal PMN-PT [Pb(Mg 2/3 Nb 1/3 )O 3 -PbTiO 3 ], a second-generation single crystal PIN-PMN-PT [Pb(In 1/2 Nb 1/2 O 3 )-Pb(Mg 1/3 Nb 2/3 O 3 )-PbTiO 3 ], and a third-generation single crystal Mn:PIN-PMN-PT in which a dopant such as Mn is added to the first and second-generation single crystals.
  • a first-generation single crystal PMN-PT [Pb(Mg 2/3 Nb 1/3 )O 3 -PbTiO 3 ]
  • PIN-PMN-PT Pb(In 1/2 Nb 1/2 O 3 )-Pb(Mg 1/3 Nb 2/3 O 3 )-PbTiO 3
  • the piezoelectric body (20) implemented with the piezoelectric single crystal material in this way is configured to have a light transmission characteristic and can configure a light irradiation path from a light source unit (50) described below.
  • a piezoelectric body (20) implemented with a piezoelectric single crystal material is manufactured in advance from an ingot obtained by putting ceramic powder into a platinum crucible loaded with seeds of a crystal growth direction ( ⁇ 001>, ⁇ 011>, or ⁇ 111> axis), sealing it, placing it in a high-temperature crystal growth furnace for a long time to completely melt it, maintaining the temperature for a predetermined period of time, and then slowly cooling it.
  • the polarization direction (crystal direction) of the piezoelectric body (20) is defined according to a relation profile, and a specific description thereof will be described later.
  • the matching layer (30) is arranged on the upper part of the piezoelectric body (20) and matches the acoustic impedance of the piezoelectric body (20) with the acoustic impedance of the target object to reduce the loss of the ultrasonic signal transmitted to the target object or the ultrasonic signal reflected from the target object. That is, the matching layer (30) reduces the difference in acoustic impedance between the piezoelectric body (20) and the target object to match the acoustic impedance between the piezoelectric body (20) and the target object, thereby performing the function of allowing the ultrasonic signal generated from the piezoelectric body (20) to be efficiently transmitted to the target object.
  • the matching layer (30) may be implemented with a material having a predefined acoustic impedance, and for example, may be implemented with a glass material or resin material having light transmittance and having an acoustic impedance that is larger than the acoustic impedance of the target object and smaller than the acoustic impedance of the piezoelectric body (20).
  • the first and second conductive members (41, 42) are respectively arranged on the first and second surfaces of the piezoelectric body (20) and function as electrodes for transmitting electrical signals to the piezoelectric body (20).
  • the first and second conductive members (41, 42) constitute part of a signal path or a ground path, which will be described later.
  • the stacking direction (hereinafter, element stacking direction) of the back layer (10), the piezoelectric body (20), and the matching layer (30), the electric field application direction (which has the same meaning as the direction in which the first and second surfaces are located based on the piezoelectric body (20)) through the first and second conductive members (41, 42), and the polarization direction of the piezoelectric body (20) are configured to have a predefined relationship profile, and the relationship profile is related to the arrangement structure of the probe unit ( PU ) to secure the high acoustic power characteristic of the device (1) by improving physical characteristics such as the mechanical quality factor (Q m ) and the coercive electric field (E C ).
  • FIG. 3 shows the arrangement structure of the probe unit (PU) according to the relationship profile.
  • the relationship profile may include a vertical profile in which the first direction (D1) and the second direction (D2) are perpendicular, and a horizontal profile in which the second direction (D2) and the third direction (D3) are horizontal.
  • the electric field application direction and the polarization direction of the piezoelectric body (20) which are perpendicular to the element stacking direction and parallel to each other, may correspond to the lateral direction (L) or the elevation direction (E) (for convenience of explanation, the electric field application direction and the polarization direction of the piezoelectric body (20) are described below as corresponding to the lateral direction (L).).
  • FIG. 3 shows an example in which the first conductive member (41) corresponds to the signal electrode (+) and the second conductive member (42) corresponds to the ground electrode (-)), the piezoelectric body (20) having the polarization direction in the lateral direction (L) vibrates in the axial direction (A), and accordingly, an ultrasonic signal is transmitted in the axial direction (A) of the piezoelectric body (20).
  • the piezoelectric body (20) applied to the probe unit (PU) is explained from the perspective of its crystal system.
  • the electric field application direction and polarization direction of the piezoelectric body (20) correspond to the ⁇ 011> axis based on the crystal system
  • the element stacking direction corresponds to the ⁇ 100> axis based on the crystal system.
  • the piezoelectric body (20) vibrates in the ⁇ 100> axis direction, and thus the relationship profile described above can be implemented.
  • the relationship profile employed in this embodiment functions as a configuration for securing high output (High Acoustic Power) characteristics of the ultrasonic probe device (1) by improving physical characteristics such as mechanical quality factor and coercive field.
  • Tables 2 to 4 below are experimental data comparing the piezoelectric constant, mechanical quality factor, and coercive field characteristics of the 'lateral (L) electrode arrangement structure and axial (A) vibration structure' (structure of this embodiment) according to the relationship profile employed in this embodiment and the conventional 'axial (A) electrode arrangement and vibration structure' (conventional structure).
  • the structure of the present embodiment can secure a piezoelectric constant at the same level as the conventional structure.
  • a high mechanical quality factor can be secured compared to the conventional structure when the piezoelectric body (20) is implemented with a second-generation and third-generation piezoelectric single crystal
  • a high coercive field can be secured compared to the conventional structure when the piezoelectric body (20) is implemented with a third-generation piezoelectric single crystal.
  • the structure of the present embodiment can secure a high mechanical quality factor and coercive field while maintaining a piezoelectric constant at the same level as the conventional structure, and accordingly, the effect of securing the high-voltage characteristics (withstand voltage) and high-output (High Acoustic Power) characteristics of the probe unit (PU) is derived.
  • first and second conductive members (41, 42) are not arranged in the transmission direction of the ultrasonic signal (i.e., the axial direction (A)), distortion of the transmitted ultrasonic signal by the first and second conductive members (41, 42) can be reduced.
  • the light source unit (50) corresponds to a configuration that irradiates therapeutic light to the target area of treatment as described below.
  • the transmission direction of the ultrasonic signal generated by the piezoelectric body (20) and the light irradiation direction from the light source unit (50) are configured in the first direction (i.e., the axial direction (A)) described above, and for this purpose, the light source unit (50) and the piezoelectric body (20) (or the probe unit (PU)) are aligned along the first direction as illustrated in FIG. 4.
  • first and second conductive members (41, 42) do not overlap with the direction of light irradiation from the light source unit (50) functions as a configuration that ensures the freedom of implementation of the first and second conductive members (41, 42). That is, when the first and second conductive members (41, 42) are arranged on the upper and lower surfaces (i.e., the axial direction (A) planes) of the piezoelectric body (20) as in the structure of a general ultrasonic probe, if the light source unit (50) and the piezoelectric body (20) are aligned along the axial direction (A), the first and second conductive members (41, 42) need to be implemented with a transparent material for the transmission of light irradiated from the light source unit (50), which causes time and cost consumption in the manufacturing process for the conductive members (41, 42).
  • light irradiated from the light source unit (50) passes through the back layer (10), the piezoelectric body (20), and the matching layer (30) and is irradiated to the target area to be treated.
  • an optical lens (L) for limiting the radiation range of the light irradiated from the light source unit (50) and focusing it to a specific range may be provided between the back layer (10) and the light source unit (50).
  • FIG. 5 is a block diagram for functionally explaining the ultrasonic-optical fusion probe device (1) of the present embodiment.
  • the ultrasonic-optical fusion probe device (1) of the present embodiment further includes an interface unit (60) and a control unit (70) along with the probe unit (PU) and light source unit (50) described above.
  • the interface unit (60) can function as an input/output device that performs interfacing between the device (1) and a user, and a typical input/output device (e.g., an operation button or a touch screen) can be included in the interface unit (60).
  • a typical input/output device e.g., an operation button or a touch screen
  • the control unit (70) basically controls the piezoelectric body (20) to vibrate in the axial direction (A) by applying an electrical signal (e.g., a pulse voltage signal) to the first and second conductive members (41, 42), thereby transmitting an ultrasonic signal from the piezoelectric body (20) in the axial direction (A), thereby implementing an ultrasonic treatment operation.
  • an electrical signal e.g., a pulse voltage signal
  • the control unit (70) basically controls the piezoelectric body (20) to vibrate in the axial direction (A) by applying an electrical signal (e.g., a pulse voltage signal) to the first and second conductive members (41, 42), thereby transmitting an ultrasonic signal from the piezoelectric body (20) in the axial direction (A), thereby implementing an ultrasonic treatment operation.
  • Diseases to which the ultrasonic treatment operation is applied may include, for example, osteoarthritis or skin diseases.
  • control unit (70) can control the photothermal treatment operation by driving the light source unit (50), and the control unit (70) can control the photothermal treatment operation by controlling the driving of the light source unit (50) through control of a driver IC (not shown) electrically connected to the light source unit (50).
  • the light source unit (50) may be configured to include a first light source that irradiates first light of a first wavelength band and a second light source that irradiates second light of a second wavelength band different from the first wavelength band, and each light source may be implemented as an LED.
  • the first wavelength band may correspond to 600 to 700 nm
  • the second wavelength band may correspond to 800 to 900 nm.
  • the first light of the first wavelength band may increase the temperature of the target irradiation area, and thus may function as a basic light source for photothermal therapy, and the second light of the second wavelength band may function as an auxiliary light source that maximizes the effect of photothermal therapy since it has high penetrability and light efficiency and can penetrate deep into tissues and be used for cell therapy.
  • light of the above wavelength band has a therapeutic effect on osteoarthritis and skin diseases.
  • the control unit (70) can selectively perform an ultrasonic treatment operation through the piezoelectric body (20) and a photothermal treatment operation through the light source unit (50) in a treatment mode for the target area to be treated, depending on the user's manipulation of the interface unit (60). That is, the control unit (70) can perform only an ultrasonic treatment operation through the piezoelectric body (20), only a photothermal treatment operation through the light source unit (50), or a combined operation of the ultrasonic treatment operation and the photothermal treatment operation, depending on the user's manipulation of the interface unit (60).
  • the control unit (70) can at least partially overlap the first and second time periods.
  • the control unit (70) can perform a basic ultrasonic treatment operation by controlling the transmission of therapeutic ultrasonic waves by the piezoelectric body (20) during a first time period (T1), and in order to maximize the treatment effect, the second time period during which the photothermal treatment operation is performed can be overlapped over the entire first time period during which the ultrasonic treatment operation is performed (photothermal treatment 1), or only a part (T OVLP ) of the first and second time periods can be overlapped with each other (photothermal treatment 2).
  • control unit (70) may not overlap the first and second time sections, but may provide a time difference (T diff ) less than or equal to a preset gap (Gap) between the first and second time sections, so that the photothermal therapy operation is performed after the ultrasonic treatment operation is completed (photothermal therapy 3).
  • the time interval corresponding to the above-mentioned gap is an upper limit of the time during which a continuous treatment effect on the affected area can be expected through the ultrasonic treatment operation and the photothermal therapy operation that are sequentially performed, and functions as a configuration for generating a synergistic effect of treatment on the affected area by allowing the ultrasonic treatment operation and the photothermal therapy operation to be performed with a time difference less than or equal to the gap.
  • the overlapping period (T OVLP ) between the first and second time intervals i.e., the period of simultaneous performance of ultrasound treatment and photothermal treatment), or the time difference (T diff ) between the first and second time intervals, can be determined by a user (e.g., a doctor) making a clinical judgment based on the progression of the disease, the temperature of the affected area, etc., and then inputting it into the interface unit (60). For example, when the progression of the disease is high and the temperature of the affected area is below the reference value, the control unit (70) can overlap the entire first and second time periods (1 in FIG.
  • control unit (70) can overlap only a part of the first and second time periods (2 in FIG. 6) depending on the user's operation of the interface; and when the progression of the disease is low and the temperature of the affected area is above the reference value, the control unit (70) can provide a time difference of less than the above-described gap between the first and second time periods depending on the user's operation of the interface.
  • control unit (70) may control the light source unit (50) in a manner of activating the first and second light sources simultaneously, or in a manner of activating the first and second light sources sequentially.
  • This method may also be determined in a manner in which the user makes a clinical judgment based on the progression of the disease, the temperature of the affected area, etc., and then inputs the judgment into the interface unit (60).
  • the treatment mode is divided into multiple treatment modes according to the disease being treated, and the frequency of the ultrasonic signal in each treatment mode can be configured to be variable.
  • the frequency of the ultrasonic signal in the treatment mode for osteoarthritis, can be set to the XX band, and in the treatment mode for skin disease, the frequency of the ultrasonic signal can be set to the 3MHz (HIFU) band.
  • This frequency variable function can be supported by the interface unit (60).
  • the element stacking direction of the ultrasonic probe, the electric field application direction to the piezoelectric body (20), and the polarization direction of the piezoelectric body are configured to have a predefined relationship profile (a vertical profile of the electric field application direction and the polarization direction with respect to the stacking direction), thereby improving physical properties such as the mechanical quality factor and the coercive field, thereby securing the high output (high acoustic power) characteristics of the ultrasonic probe.
  • the treatment effect on the affected area e.g., bone joint or skin
  • the treatment effect on the affected area can be maximized by simultaneously applying ultrasonic treatment by the ultrasonic probe and photothermal treatment by the light source unit, and by adopting a structure in which the ultrasonic probe and the light source unit are aligned according to the transmission direction of the ultrasonic signal and light, the size of the entire probe device can be reduced.
  • the first and second conductive members are arranged on the side surfaces of the piezoelectric body by the above-described relationship profile, the light irradiated from the light source unit and the first and second conductive members do not overlap each other, and therefore, when the first and second conductive members are arranged on the upper and lower surfaces of the piezoelectric body, the dependency on the transparent material of the conductive member required is eliminated, and thus the degree of freedom in designing and implementing the conductive member can be improved.
  • unit may include a unit implemented in hardware, software or firmware, and may be used interchangeably with terms such as logic, logic block, component, or circuit.
  • a unit may be a component that is configured integrally or a minimum unit of the component that performs one or more functions or a part thereof.
  • a module may be implemented in the form of an ASIC (Application-Specific Integrated Circuit).
  • the implementations described herein may be implemented in, for example, a method or process, an apparatus, a software program, a data stream or a signal.
  • the implementation of the discussed feature may also be implemented in other forms (e.g., as an apparatus or a program).
  • the apparatus may be implemented in suitable hardware, software and firmware, etc.
  • the method may be implemented in a device such as a processor, which generally refers to a processing device including, for example, a computer, a microprocessor, an integrated circuit or a programmable logic device.
  • the processor also includes communication devices, such as computers, cell phones, personal digital assistants ("PDAs”), and other devices that facilitate communication of information between end-users.
  • PDAs personal digital assistants

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Abstract

Un dispositif de sonde ultrasonore-optique combinées, selon un aspect de la présente invention, comprend : une unité de source de lumière permettant d'irradier de la lumière ; un corps piézoélectrique permettant des transmettre la lumière irradiée par l'unité de source de lumière, le sens de transmission d'un signal ultrasonore généré par le corps piézoélectrique étant le même que le sens d'irradiation de lumière venant de l'unité de source de lumière ; et des premier et second éléments conducteurs disposés, respectivement, sur des première et seconde surfaces du corps piézoélectrique de sorte que le chevauchement du sens de transmission du signal ultrasonore et du sens d'irradiation de lumière est évité.
PCT/KR2023/008929 2023-06-26 2023-06-27 Dispositif de sonde ultrasonore-optique combinées Pending WO2025005316A1 (fr)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011200374A (ja) * 2010-03-25 2011-10-13 Panasonic Corp 光治療プローブ及び光治療装置
US8206326B2 (en) * 2008-03-04 2012-06-26 Sound Surgical Technologies, Llc Combination ultrasound-phototherapy transducer
KR20150135335A (ko) * 2013-03-15 2015-12-02 소노비아 홀딩스 엘엘씨 광 및 초음파 트랜스듀서 장치
CN111888646A (zh) * 2020-07-17 2020-11-06 深圳市保身欣科技电子有限公司 一种基于多种物理因子的复合理疗电极及复合理疗装置
KR20210127608A (ko) * 2020-04-14 2021-10-22 (주)메딕콘 초음파 및 led광을 이용한 피부 미용 장치
KR20220029003A (ko) * 2020-09-01 2022-03-08 포항공과대학교 산학협력단 투명 초음파 센서 기반 초음파 광학 복합 이미징 시스템

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8206326B2 (en) * 2008-03-04 2012-06-26 Sound Surgical Technologies, Llc Combination ultrasound-phototherapy transducer
JP2011200374A (ja) * 2010-03-25 2011-10-13 Panasonic Corp 光治療プローブ及び光治療装置
KR20150135335A (ko) * 2013-03-15 2015-12-02 소노비아 홀딩스 엘엘씨 광 및 초음파 트랜스듀서 장치
KR20210127608A (ko) * 2020-04-14 2021-10-22 (주)메딕콘 초음파 및 led광을 이용한 피부 미용 장치
CN111888646A (zh) * 2020-07-17 2020-11-06 深圳市保身欣科技电子有限公司 一种基于多种物理因子的复合理疗电极及复合理疗装置
KR20220029003A (ko) * 2020-09-01 2022-03-08 포항공과대학교 산학협력단 투명 초음파 센서 기반 초음파 광학 복합 이미징 시스템

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