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WO2025097340A1 - Crème cutanée anti-âge capable d'inhiber des radicaux libres dans la peau humaine - Google Patents

Crème cutanée anti-âge capable d'inhiber des radicaux libres dans la peau humaine Download PDF

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Publication number
WO2025097340A1
WO2025097340A1 PCT/CN2023/130510 CN2023130510W WO2025097340A1 WO 2025097340 A1 WO2025097340 A1 WO 2025097340A1 CN 2023130510 W CN2023130510 W CN 2023130510W WO 2025097340 A1 WO2025097340 A1 WO 2025097340A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin cream
skin
total weight
extract
ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2023/130510
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English (en)
Inventor
Yu-Hsin Tung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nc Baby Co Ltd
Original Assignee
Nc Baby Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nc Baby Co Ltd filed Critical Nc Baby Co Ltd
Priority to PCT/CN2023/130510 priority Critical patent/WO2025097340A1/fr
Publication of WO2025097340A1 publication Critical patent/WO2025097340A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the present disclosure relates to an anti-aging skin cream capable of inhibiting free radicals in human skin, and more particularly to an anti-aging skin cream that consists of fullerene and a multiple of natural herb extracts, eliminates free radicals by means of the chemical affinity property of the free radicals of fullerene, and acts as a synergy agent with the natural herb extracts to retard skin aging and improve skin quality.
  • free radicals In human metabolic process, unstable and active molecules called free radicals are naturally produced. The amount of free radicals is usually maintained in equilibrium state to play a defensive role. For example, when encountering bacteria and viruses, the body defense system will prepare phagocytes that produce superoxide anion radicals during the catalysis of related enzymes to eliminate the bacteria and viruses and restore physical health.
  • Skin is the largest organ of the body, which can resist external invasion. It has the functions of keeping warm, providing protective barrier, retaining moisture, etc.
  • night sleep is the peak time for the metabolism of skin cells, and if a person does not have enough sleep, the body will produce excessive free radicals, which will lead to the thickening of stratum corneum, the yellowing of skin, and the occurrence of dark spots and other physiological phenomena, and in turn will make us look older. Therefore, how to slow down the production of free radicals in the skin to retard skin aging and prevent skin damage has been a research subject in the medical and related industry.
  • fullerene with the property of eliminating various free radicals is one of the feasible solutions.
  • how to correctly apply fullerene in an appropriate proportion to the skin and synergize it with other ingredients that are beneficial to the skin in terms of anti-aging is an issue that the present discloser intends to improve.
  • the present disclosure relates to an anti-aging skin cream capable of inhibiting free radicals in human skin
  • the formula of the skin cream includes an ingredient A, an ingredient B, an ingredient C, and an ingredient D, plus aqua 73.00 ⁇ 75.00%, a surfactant 0.50 ⁇ 2.00%, and a thickener 0.50 ⁇ 1.50%, which are measured according to the percentage of total weight of the skin cream, and these ingredients are mixed and blended to form the anti-aging skin cream, wherein:
  • the ingredient A consists of butylene glycol 7.50 ⁇ 8.50%and pentylene glycol 4.50 ⁇ 5.50%, which are measured according to the percentage of total weight of the skin cream;
  • the ingredient B consists of: simmondsia chinensis (jojoba) seed oil 4.50 ⁇ 5.50%, cordyceps sinensis extract 0.70 ⁇ 1.70%, rosa damascena flower water 0.10 ⁇ 1.30%, sodium hyaluronate 0.10 ⁇ 0.80%, dipotassium glycyrrhizate 0.10 ⁇ 0.70%, morus alba root extract 0.10 ⁇ 0.60%, glycosyl trehalose 0.10 ⁇ 0.60%, allantoin 0.10 ⁇ 0.20%, fullerene 0.10 ⁇ 0.60%, and lactococcus/bean seed extract ferment filtrate 0.10 ⁇ 0.60%, which are measured according to the percentage of total weight of the skin cream;
  • the ingredient C consists of: tocopheryl acetate 0.50 ⁇ 2.00%and panthenol 0.10 ⁇ 1.00%, which are measured according to the percentage of total weight of the skin cream;
  • the ingredient D consists of: an anti-allergic and anti-inflammatory extract with a weight equal to 0.10 ⁇ 0.60%of the total weight of the skin cream, and the anti-allergic and anti-inflammatory extract consists of chrysanthemum parthenium extract, camellia sinensis leaf extract, and magnolo.
  • the skin cream utilizes the properties of the fullerene and free radicals, and works synergistically with other components to effectively achieve the effects of eliminating free radicals, inhibiting melanin, improving redness on the cheeks, inhibiting sebaceous oxidation, tightening pores, isolating UV rays, preventing acnes, reducing wrinkles, and retarding skin aging, etc.
  • the skin cream can also be used as an antioxidant to protect the skin from the harmful effects of free radicals.
  • Cordyceps sinensis extract contains polysaccharides, amino acids, peptides (proteins) , nucleic acids and vitamins, SOD (antioxidant enzymes) , etc., which can eliminate free radicals and enhance the immunity of skin.
  • Rosa damascena flower water has the effects of moisturizing, soothing, tightening and repairing skin.
  • the ingredient C consists of tocopheryl acetate 0.50 ⁇ 2.00%and panthenol 0.10 ⁇ 1.00%which are measured according to the percentage of total weight of the skin cream;
  • the ingredient D consists of an anti-allergic and anti-inflammatory extract 0.10 ⁇ 0.60%which is measured according to the percentage of total weight of the skin cream, and the anti-allergic and anti-inflammatory extract contains: chrysanthemum parthenium extract, camellia sinensis leaf extract and magnolo, plus an appropriate amount of aqua, butylene glycol, propylene glycol and lecithin, which are blended to form the ingredient D.
  • the skin cream further includes a fragrance 0.01 ⁇ 0.05%, which is measured according to the percentage of total weight of the skin cream, to add sweet aroma and enhance the feeling of use.
  • the skin cream manufactured by the ingredients with the specific range of the percentage by weight according to the present disclosure has been applied to human skin for a long period.
  • This experiment group is compared with a control group that did not use the skin cream, and the results show that the experiment group can effectively improve the skin condition, and the specific efficacy includes inhibiting melanin, improving the skin redness, inhibiting sebum oxidation, tightening pores, isolating UV rays, preventing acnes, reducing wrinkles, preventing aging, etc.
  • the aqua measured according to the percentage of total weight of the skin cream is 74.37%;
  • the surfactant measured according to the most preferable percentage of total weight of the skin cream is 1.50%, and the thickener measured according to the most preferable percentage of total weight of the skin cream is 1.00%;
  • composition of the ingredient A consists of: butylene glycol 8.00%and pentylene glycol 5.00%, which are measured according to the most preferable percentage of total weight of the skin cream;
  • the composition of the ingredient B consists of simmondsia chinensis (jojoba) seed oil 5.00%, cordyceps sinensis extract 1.20%, rosa damascena flower water 0.80%, sodium hyaluronate 0.30%, dipotassium glycyrrhizate 0.20%, morus alba root extract 0.10%, glycosyl trehalose 0.10%, allantoin 0.10, fullerene 0.10%, lactococcus/bean seed extract ferment filtrate 0.10%, which are measured according to the most preferable percentage of total weight of the skin cream;
  • composition of the ingredient C includes tocopheryl acetate with a weight preferably equal to 1.50%of the total weight of the skin cream and panthenol with a weight preferably equal to 0.50%of the total weight of the skin cream;
  • the ingredient D of the skin cream preferably includes an anti-allergic and anti-inflammatory extract with a weight equal to 0.10%of the total weight of the skin cream;
  • the fragrance of the skin cream preferably has a weight equal to 0.03%of the total weight of the skin cream.
  • the surfactant further consists of ammonium acryloyldimethyltaurate/VP copolymer
  • the thickener consists of carbomer
  • the percentages by weight of the ingredients of the skin cream are disclosed.
  • a comparison between the experiment group that has applied the skin cream to skin for a long time and the control group that has not used the skin cream at all is made, showing that the experiment group can effectively improve the skin condition, and the specific efficacy includes inhibiting melanin, improving the skin redness, inhibiting sebum oxidation, tightening pores, isolating UV rays, preventing acnes, reducing wrinkles, preventing aging, etc.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

Une crème cutanée anti-âge capable d'inhiber les radicaux libres dans la peau humaine pour améliorer efficacement l'état de la peau, inhiber la mélanine, améliorer les rougeurs cutanées, inhiber l'oxydation du sébum, resserrer les pores, isoler les rayons UV, prévenir les acnés, réduire les rides, retarder le vieillissement de la peau, etc., comprend l'aqua, le butylène glycol, le pentylène glycol, l'huile de graines de simmondsia chinensis (jojoba), l'extrait de cordyceps sinensis, l'eau de fleur de rosa damascena, le hyaluronate de sodium, le glycyrrhizate de dipotassium, l'extrait de racine de morus alba, le glycosyl tréhalose, l'allantoïne, le fullerène, le filtrat de ferment d'extrait de graine de haricot/lactococcus, l'acétate de tocophéryle, le panthénol, un extrait anti-allergique et anti-inflammatoire, un tensioactif et un épaississant.
PCT/CN2023/130510 2023-11-08 2023-11-08 Crème cutanée anti-âge capable d'inhiber des radicaux libres dans la peau humaine Pending WO2025097340A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2023/130510 WO2025097340A1 (fr) 2023-11-08 2023-11-08 Crème cutanée anti-âge capable d'inhiber des radicaux libres dans la peau humaine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2023/130510 WO2025097340A1 (fr) 2023-11-08 2023-11-08 Crème cutanée anti-âge capable d'inhiber des radicaux libres dans la peau humaine

Publications (1)

Publication Number Publication Date
WO2025097340A1 true WO2025097340A1 (fr) 2025-05-15

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Country Status (1)

Country Link
WO (1) WO2025097340A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103976935A (zh) * 2014-05-28 2014-08-13 广州市白云区天芳化妆品厂 一种抗衰原液及其制备方法
CN107308030A (zh) * 2017-06-09 2017-11-03 佛山市汇汾化妆品科技有限公司 一种抗衰老活肤面霜
CN108478519A (zh) * 2018-04-23 2018-09-04 广州雷诺生物科技有限公司 一种含富勒烯的矿物水光原液
WO2018180009A1 (fr) * 2017-03-30 2018-10-04 ビタミンＣ６０バイオリサーチ株式会社 Composition cosmétique contenant du fullerène
CN108836882A (zh) * 2018-08-30 2018-11-20 广州市美驰化妆品有限公司 一种具有美白祛斑功能的类脂质体和护肤品组合物
CN112137933A (zh) * 2020-10-22 2020-12-29 广州源美药业科技有限公司 一种具有美白补水修复功效的组合物
CN113750029A (zh) * 2020-06-07 2021-12-07 美歆然化妆品(上海)有限公司 一种舒缓修护精华液及其制备方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103976935A (zh) * 2014-05-28 2014-08-13 广州市白云区天芳化妆品厂 一种抗衰原液及其制备方法
WO2018180009A1 (fr) * 2017-03-30 2018-10-04 ビタミンＣ６０バイオリサーチ株式会社 Composition cosmétique contenant du fullerène
CN107308030A (zh) * 2017-06-09 2017-11-03 佛山市汇汾化妆品科技有限公司 一种抗衰老活肤面霜
CN108478519A (zh) * 2018-04-23 2018-09-04 广州雷诺生物科技有限公司 一种含富勒烯的矿物水光原液
CN108836882A (zh) * 2018-08-30 2018-11-20 广州市美驰化妆品有限公司 一种具有美白祛斑功能的类脂质体和护肤品组合物
CN113750029A (zh) * 2020-06-07 2021-12-07 美歆然化妆品(上海)有限公司 一种舒缓修护精华液及其制备方法
CN112137933A (zh) * 2020-10-22 2020-12-29 广州源美药业科技有限公司 一种具有美白补水修复功效的组合物

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