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WO2025094692A1 - Régulateur d'humidité et composition filmogène sensible à l'humidité contenant ledit régulateur - Google Patents

Régulateur d'humidité et composition filmogène sensible à l'humidité contenant ledit régulateur Download PDF

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Publication number
WO2025094692A1
WO2025094692A1 PCT/JP2024/037092 JP2024037092W WO2025094692A1 WO 2025094692 A1 WO2025094692 A1 WO 2025094692A1 JP 2024037092 W JP2024037092 W JP 2024037092W WO 2025094692 A1 WO2025094692 A1 WO 2025094692A1
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Prior art keywords
humidity
film
composition
less
regulator
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English (en)
Japanese (ja)
Inventor
敦 曽我部
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Shiseido Co Ltd
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Shiseido Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere

Definitions

  • This disclosure relates to a humidity regulator and a composition for forming a humidity-responsive film that contains the regulator.
  • Patent Document 1 discloses a moisture-permeable film for use in clothing, etc., that contains a matrix resin and collagen powder made of cross-linked regenerated collagen and has a degree of openness of 1 to 95%.
  • Patent Document 2 discloses a wound bed environment adjustment sheet that uses a moisture-permeable hydrogel sheet and is applied to the affected area of a skin wound.
  • Patent Document 3 discloses a moisturizing film cosmetic that contains a polyvinyl alcohol film.
  • Patent Document 4 discloses an emulsion cosmetic that includes an aqueous phase containing water and polyvinyl alcohol, and an oil phase containing oil, in which the polyvinyl alcohol content is 0.5 mass% or more relative to the total amount of the emulsion cosmetic.
  • JP 2010-077202 A International Publication No. 2012/036064 International Publication No. 2021/002124 International Publication No. 2022/130964
  • the present inventor has developed cosmetics and the like with humidity responsive properties that can reduce sticky discomfort in high humidity environments or when sweating, while moisturizing the skin in low humidity environments to provide beauty effects, as described in Patent Documents 3 and 4.
  • the main ingredient used in such cosmetics is polyvinyl alcohol, a synthetic polymer derived from petroleum, and there has been a demand for the use of environmentally friendly naturally derived ingredients.
  • the subject of the present disclosure is therefore to provide a humidity regulator containing naturally derived components, which can be used to prepare a film that exhibits humidity responsiveness similar to that of a polyvinyl alcohol film, a synthetic polymer derived from petroleum, and a composition for forming a humidity-responsive film that contains the regulator.
  • a humidity regulator containing polysaccharides containing polysaccharides.
  • the polysaccharide comprises at least one selected from the group consisting of xanthan gum, hydroxypropyl methylcellulose, hydroxypropyl cellulose, stearoxy hydroxypropyl methylcellulose, hydroxyethyl cellulose, polyoctanium-10, guar hydroxypropyltrimonium chloride, and pullulan.
  • Aspect 3 A humidity-responsive film-forming composition comprising the regulator according to aspect 1 or 2.
  • ⁇ Aspect 4> 4 4. The composition of claim 3, wherein a humidity responsive film formed by the composition exhibits a humidity responsiveness of greater than 1.00.
  • Aspect 6 Aspect 6. The composition according to any one of aspects 3 to 5, comprising at least one selected from the group consisting of erythritol, trehalose, citric acid, 4-methoxysalicylic acid or a salt thereof, and niacinamide.
  • Aspect 7 A composition according to aspect 6, wherein a mass ratio of a total amount of the at least one selected from the group consisting of erythritol, trehalose, citric acid, 4-methoxysalicylic acid or a salt thereof, and niacinamide to the polysaccharide is 0.01 or more.
  • ⁇ Aspect 8> A composition according to any one of Aspects 3 to 7, which is a cosmetic preparation.
  • ⁇ Aspect 9> A method of using polysaccharides as a humidity regulator.
  • Aspect 10 A method for using a composition containing a humidity regulator including a polysaccharide as a humidity-responsive film-forming composition.
  • the present disclosure provides a humidity regulator containing naturally derived ingredients that can be used to prepare a film that exhibits humidity responsiveness similar to that of a polyvinyl alcohol film, a synthetic polymer derived from petroleum, and a composition for forming a humidity-responsive film that contains the regulator.
  • FIG. 1 is a graph showing the humidity response performance when various polysaccharides are used.
  • FIG. 2 is a graph evaluating components that affect humidity responsiveness when used in combination with polysaccharides.
  • FIG. 3 is a graph evaluating the effect of a humidity responsiveness improving component on various polysaccharides.
  • FIG. 4 is a schematic diagram of a measurement specimen sealed with a measurement sample, which is used when measuring the transmittance.
  • the humidity regulator of the present disclosure includes a polysaccharide, and the humidity-responsive film-forming composition of the present disclosure includes the humidity regulator.
  • Patent Document 3 Polyvinyl alcohol (hereinafter sometimes referred to as "PVA") used in Patent Document 3 and the like is generally known to have excellent affinity with moisture.
  • PVA Polyvinyl alcohol
  • FIG. 1 of Patent Document 3 when a PVA film 101 is applied to the skin, moisture 105 evaporated from the skin binds to PVA molecules 103 in the film, and the PVA molecules 103 move so as to attract each other around the moisture 105, and it was thought that gaps 107 that allow moisture to pass through are generated. Therefore, in a low humidity environment, the PVA molecules 103 do not move near the outermost surface of the PVA film 101, so that gaps 107 that allow moisture to pass through are not formed, while, on the other hand, as shown in FIG.
  • the inventors believe that the crystallization in PVA film is caused by the action of hydrogen bonds associated with the hydroxyl groups of PVA. As such, they assumed that the crystalline structure associated with the hydroxyl groups of PVA contributes to humidity responsiveness, and similarly assumed that naturally occurring components that have hydroxyl groups and can exhibit a crystalline structure would be able to exhibit humidity responsiveness, and so they carried out material selection work. As a result, the inventors discovered that, among the various naturally occurring components, polysaccharides can be used to form a film that exhibits humidity responsiveness similar to PVA film, and that these polysaccharides can be used as humidity regulators. They believe that films prepared using polysaccharides can exhibit humidity responsiveness because, due to the influence of moisture, amorphous parts and crystalline parts can be generated in the same way as PVA films.
  • humidity responsiveness refers to the ability to change the amount of moisture evaporation in response to changes in the humidity environment, specifically, the ability to make the amount of moisture evaporation in a low humidity environment less than the amount of moisture evaporation in a high humidity environment.
  • humidity responsiveness can be evaluated, for example, by the value of the transmittance at atmospheric pressure, 28°C, and a relative humidity of 70%, relative to the transmittance at atmospheric pressure, 28°C, and a relative humidity of 30%, using a film prepared by the method described below.
  • a "low humidity environment” refers to an environment in which the relative humidity at atmospheric pressure and 28° C. is less than 50% RH, 45% RH or less, 40% RH or less, 35% RH or less, 30% RH or less, 25% RH or less, or 20% RH or less.
  • such relative humidity can be converted to weight absolute humidity that is not affected by temperature, for example, and the weight absolute humidity can be 8.7 g/kg or less, 7.9 g/kg or less, 7.0 g/kg or less, 6.1 g/kg or less, 5.4 g/kg or less, 5.2 g/kg or less, 5.0 g/kg or less, or 4.8 g/kg or less, and can be 0.52 g/kg or more, 0.86 g/kg or more, 1.2 g/kg or more, or 1.7 g/kg or more.
  • a "high humidity environment” refers to an environment in which the relative humidity at atmospheric pressure and 28°C is 50% RH or more, 55% RH or more, 60% RH or more, 65% RH or more, 70% RH or more, or 75% RH or more.
  • the upper limit of such relative humidity can be, for example, 100% RH or less or less than 100% RH.
  • such relative humidity can be converted into weight absolute humidity that is not affected by temperature, and the weight absolute humidity can be 12 g/kg or more, 13 g/kg or more, 14 g/kg or more, 15 g/kg or more, 17 g/kg or more, or 18 g/kg or more, and can be 24 g/kg or less or less than 24 g/kg.
  • film includes not only films that can be carried alone, such as wrap film, but also thin films that cannot be carried alone, such as coating films.
  • films that can be carried alone, such as wrap film can be distinguished as “self-supporting films,” and thin films that cannot be carried alone as “non-self-supporting films.”
  • beauty or “beauty method” refers to applying the humidity-responsive film-forming composition of the present disclosure to a target area (e.g., the body surface) to beautify the condition of the target area or a method for beautifying the condition of the body surface, and is different from methods of surgery, treatment, or diagnosis of humans.
  • body surface means the skin surface of the body.
  • the humidity regulator of the present disclosure includes a polysaccharide.
  • a film obtained using the polysaccharide can exhibit humidity responsiveness, i.e., has the ability to control humidity, so that the polysaccharide can be used as a humidity regulator.
  • the amount of polysaccharides in the humidity regulator can be, for example, 5.0% by mass or more, 10% by mass or more, 30% by mass or more, 50% by mass or more, 70% by mass or more, 80% by mass or more, or 90% by mass or more, or it can be 100% by mass or less, or less than 100% by mass, based on the total amount of the humidity regulator.
  • the polysaccharides can be blended appropriately within such ranges.
  • polysaccharide refers to a general term for a long chain of monosaccharides (e.g., glucose and mannose, etc.), and more specifically, refers to a carbohydrate composed of 5 or more, 8 or more, 10 or more, or 15 or more monosaccharides bonded together.
  • polysaccharide can include not only polysaccharides but also derivatives thereof.
  • examples of polysaccharide derivatives include water-soluble alkyl-substituted polysaccharide derivatives. Polysaccharides can be used alone or in combination of two or more kinds.
  • polysaccharide for example, polysaccharides exhibiting nonionic, cationic, or anionic properties can be used. Among them, nonionic and cationic polysaccharides are preferred from the viewpoints of film-forming properties and humidity responsiveness, etc.
  • polysaccharides include at least one selected from the group consisting of sodium hyaluronate, agar, sodium alginate, xanthan gum, hydroxypropyl methylcellulose, hydroxypropyl cellulose, stearoxy hydroxypropyl methylcellulose, hydroxyethyl cellulose, polyoctanium-10, guar hydroxypropyltrimonium chloride, and pullulan.
  • xanthan gum hydroxypropyl methylcellulose, hydroxypropyl cellulose, stearoxy hydroxypropyl methylcellulose, hydroxyethyl cellulose, polyoctanium-10, guar hydroxypropyltrimonium chloride, and pullulan are preferred, hydroxypropyl methylcellulose, hydroxypropyl cellulose, stearoxy hydroxypropyl methylcellulose, hydroxyethyl cellulose, and guar hydroxypropyltrimonium chloride are more preferred, hydroxypropyl cellulose and guar hydroxypropyltrimonium chloride are even more preferred, and hydroxypropyl cellulose is particularly preferred.
  • these components are contained in an amount of 50% by mass or more, more than 50% by mass, 60% by mass or more, 70% by mass or more, 80% by mass or more, or 90% by mass or more of the total amount of polysaccharide used.
  • amount used There is no particular upper limit to the amount used, and it can be, for example, 100% by mass or less or less than 100% by mass.
  • the humidity regulator of the present disclosure can be blended with various additives within a range that does not adversely affect the effects of the present invention.
  • optional components include, for example, moisturizers, water-soluble polymers, oil-soluble polymers, sequestering agents, neutralizing agents, surfactants, lower alcohols, various extracts, UV absorbers, skin nutrients, vitamins, water-soluble drugs applicable to medicines, quasi-drugs, cosmetics, etc., antioxidants, buffers, preservatives, antioxidant assistants, dispersants, propellants, pigments, pearling agents, dyes, colorings, fragrances, water, oils, acid components, and alkali components.
  • Optional components can be used alone or in combination of two or more.
  • the humidity-responsive film-forming composition of the present disclosure includes the humidity regulator described above. Since a composition containing the humidity regulator of the present disclosure, which includes the polysaccharide described above, can form a humidity-responsive film, it can be said that such a composition can be used as a humidity-responsive film-forming composition (sometimes simply referred to as a "composition").
  • the composition of the present disclosure can exhibit humidity responsiveness at the application site when the composition is applied to a target site (e.g., a body surface or wall) to form a film.
  • a target site e.g., a body surface or wall
  • Such humidity responsiveness can be evaluated based on the value of the permeability at atmospheric pressure and a relative humidity of 70% at 28°C, compared to the permeability at atmospheric pressure and a relative humidity of 30%, as described in the humidity responsiveness test described below.
  • these two permeabilities can be determined from the regression line obtained from a graph of the permeability values at several relative humidities and the relative humidity, as described below, created with the Y-axis representing the permeability and the X-axis representing the relative humidity.
  • ⁇ Method of measuring transmittance> As shown in Fig. 4, the open part (radius: 0.7 cm, area: 1.54 cm2 ) of a vial containing 12 mL of water is covered with a film of a measurement sample prepared using the composition, and the sample is allowed to stand in a low humidity environment, for example, at 28°C and 30% RH, until the amount of evaporation reaches an equilibrium state where it is at least approximately constant over time.
  • the transmittance can then be calculated using the following formulas 1 and 2.
  • w1 and w0 respectively refer to the weights (g) of the measurement sample before and after the test
  • the surface area is the surface area ( m2 ) of the film at the open part of the vial
  • the time is the measurement time (h) of the amount of water evaporation in an equilibrium state.
  • P inside and P outside respectively refer to the internal pressure (Pa) in the vial where the relative humidity can be assumed to be 100%, and the external pressure (Pa) under the set humidity environment.
  • the measurement sample film can be obtained by preparing a composition by mixing and stirring polysaccharide and ion-exchanged water in a 10 mL vial so that the polysaccharide concentration is 5 mass %, and then adding 3.0 g of the obtained composition to a roughly circular petri dish having an area of 19.6 cm2 and drying it to prepare a film with a thickness of approximately 60 ⁇ m.
  • a film (sometimes simply referred to as a "film") prepared using the composition of the present disclosure can exhibit humidity responsiveness such that, for example, the transmittance when measured in a low humidity environment of 28°C and 30% RH is less than the transmittance when measured in a high humidity environment of 28°C and 70% RH.
  • the transmittance when measured in a low humidity environment of 28°C and 30% RH is approximately equal to the transmittance when measured in a high humidity environment of 28°C and 70% RH.
  • the composition of the present disclosure can exhibit a humidity responsiveness of more than 1.00 or 1.05 or more, preferably 1.10 or more or 1.15 or more, and more preferably 1.20 or more or 1.25 or more, in terms of the humidity responsiveness using the above-mentioned transmittance in a film prepared using the composition.
  • a humidity responsiveness of more than 1.00 or 1.05 or more, preferably 1.10 or more or 1.15 or more, and more preferably 1.20 or more or 1.25 or more, in terms of the humidity responsiveness using the above-mentioned transmittance in a film prepared using the composition.
  • There is no particular limit to the upper limit of such humidity responsiveness and it can be, for example, 2.00 or less, 1.90 or less, or 1.80 or less.
  • a film prepared using the composition of the present disclosure can better suppress evaporation of moisture. Therefore, the humidity responsiveness value using the above-mentioned transmittance tends to increase as the difference in the humidity environment of the measurement environment increases.
  • the humidity-responsive film-forming composition of the present disclosure contains a polysaccharide that can function as a humidity regulator.
  • the amount of such polysaccharide to be blended varies depending on the formulation type of the composition, and is not particularly limited as long as the concentration is such that a humidity-responsive film can be formed.
  • the amount to be blended can be, for example, 1.0% by mass or more, 5.0% by mass or more, 10% by mass or more, 20% by mass or more, 30% by mass or more, 40% by mass or more, 50% by mass or more, 60% by mass or more, 70% by mass or more, 80% by mass or more, or 90% by mass or more, and can be 100% by mass or less, less than 100% by mass, 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, 50% by mass or less, 40% by mass or less, 30% by mass or less, 20% by mass or less, or 10% by mass or less, relative to the total amount of the composition.
  • the polysaccharide can be blended appropriately within such ranges.
  • the dosage form of the composition of the present disclosure is not particularly limited, and may be, for example, a single phase, or an oil-in-water or water-in-oil emulsion. These can be appropriately prepared by a conventional method.
  • the term "single phase” refers to a single phase that is substantially composed of an aqueous phase.
  • substantially refers to, for example, the fact that an oil (e.g., an oil-soluble UV absorber) is solvated or solubilized by alcohol or the like and incorporated slightly into the aqueous phase, but does not include oil droplets (emulsion particles) emulsified by a surfactant or the like, as in an oil-in-water emulsion composition.
  • an oil e.g., an oil-soluble UV absorber
  • composition of the present disclosure is not particularly limited, and examples include liquid, emulsion, cream, gel, mist, spray, aerosol, mousse, etc.
  • the composition of the present disclosure can be used as a cosmetic.
  • the product form of the composition is not particularly limited, and examples include skin care cosmetics such as lotion, cream, face oil, body oil, and serum; makeup cosmetics such as foundation, makeup base, lipstick, blusher, eye shadow, mascara, and mascara base; and sunscreen cosmetics.
  • the composition of the present disclosure can exhibit excellent beauty effects such as improving skin sweating and moisturizing effects, and therefore can be suitably used as a cosmetic.
  • composition of the present disclosure can be used for applications other than cosmetics, particularly applications requiring humidity responsiveness, because the resulting film exhibits humidity responsiveness.
  • applications include medical applications (e.g., bandages, medical tapes), clothing applications, construction applications (e.g., wallpaper), and agricultural applications (e.g., vinyl greenhouses or plant cultivation).
  • the composition may be applied to a moisture-permeable substrate, or a film formed using the composition may be used as is or laminated to a moisture-permeable substrate.
  • components include humidity responsiveness improvers, moisturizers (e.g., 1,3-butylene glycol, propylene glycol, dynamite glycerin, etc.), surfactants (anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants), water-soluble polymers, rubbers, elastomers, pressure sensitive adhesives, adhesives, adhesion modifiers, adhesion modifiers, UV absorbers, antioxidants, preservatives, antioxidant assistants, crosslinking agents, light diffusing agents, fillers, neutralizing agents, lower alcohols such as ethanol, polyhydric alcohols such as PEG 6000 and dipropylene glycol, higher alcohols such as batyl alcohol, various extracts, sugars, amino acids, organic amines, polymer emulsions, chelating agents, UV scattering agents,
  • the optional "humidity response improver" in the present disclosure is intended to mean an agent that improves the humidity response performance of a film prepared using a composition obtained by blending the agent in a composition containing the polysaccharide of the present disclosure, compared to a film prepared using a composition not containing the agent.
  • Specific examples of such humidity response improvers include at least one selected from the group consisting of erythritol, trehalose, citric acid, 4-methoxysalicylic acid or a salt thereof, and niacinamide. Of these, 4-methoxysalicylic acid or a salt thereof is preferred.
  • citric acid does not include citrates such as sodium citrate.
  • salts of 4-methoxysalicylic acid include sodium salts and potassium salts.
  • the amount of humidity responsiveness enhancer used is preferably such that the mass ratio of the humidity enhancer (e.g., the total amount of at least one selected from the group consisting of erythritol, trehalose, citric acid, 4-methoxysalicylic acid or a salt thereof, and niacinamide) to the polysaccharide is 0.01 or more or 0.05 or more, more preferably 0.06 or more or 0.08 or more, and even more preferably 0.1 or more, 0.2 or more, 0.3 or more, 0.4 or more, or 0.5 or more.
  • the upper limit of such mass ratio can be, for example, 10 or less, 5 or less, 3 or less, 1 or less, 0.9 or less, 0.8 or less, 0.7 or less, 0.6 or less, or 0.5 or less.
  • anionic components may be incorporated into the composition as long as they do not adversely affect the effects of the present invention. From the viewpoint of humidity responsiveness, however, it is preferable that the amount of anionic components such as anionic surfactants incorporated is 10% by mass or less, 5.0% by mass or less, 1.0% by mass or less, 0.5% by mass or less, 0.1% by mass or less, 0.05% by mass or less, or 0.01% by mass or less relative to the total amount of the composition, and it is more preferable that no anionic components are contained in the composition.
  • Humidity-responsive film The composition of the present disclosure can provide a film that exhibits the humidity responsiveness described above.
  • the thickness of the film prepared using the composition of the present disclosure is not particularly limited, and can be appropriately adjusted depending on the location where the composition of the present disclosure is applied, the purpose of use, or the balance of humidity responsiveness when combined with a waterproof and moisture-permeable layer described later.
  • the film thickness can be, for example, 1 mm or less, 500 ⁇ m or less, 300 ⁇ m or less, 100 ⁇ m or less, 70 ⁇ m or less, 50 ⁇ m or less, 20 ⁇ m or less, 15 ⁇ m or less, 13 ⁇ m or less, 10 ⁇ m or less, 7 ⁇ m or less, 5 ⁇ m or less, 3 ⁇ m or less, 1 ⁇ m or less, 0.5 ⁇ m or less, or 0.1 ⁇ m or less, and can be 0.01 ⁇ m or more, 0.05 ⁇ m or more, 0.1 ⁇ m or more, 0.5 ⁇ m or more, or 1 ⁇ m or more.
  • the thickness of the film when used in combination with a waterproof and moisture permeable layer described later, can be as thin as 100 ⁇ m or less, 70 ⁇ m or less, 50 ⁇ m or less, 40 ⁇ m or less, 30 ⁇ m or less, 20 ⁇ m or less, 15 ⁇ m or less, 13 ⁇ m or less, 10 ⁇ m or less, 7 ⁇ m or less, 5 ⁇ m or less, 3 ⁇ m or less, 1 ⁇ m or less, 0.7 ⁇ m or less, or 0.5 ⁇ m or less, and can be 0.01 ⁇ m or more, 0.05 ⁇ m or more, 0.1 ⁇ m or more, 0.2 ⁇ m or more, or 0.3 ⁇ m or more.
  • the thickness can be defined as the average value calculated by measuring the thickness of any part of the film at least five times using a high-precision digital micrometer (MDH-25MB, manufactured by Mitutoyo Corporation). If the film is too thin to be measured with a high-precision digital micrometer, the thickness can be determined using a similar method using a scanning electron microscope as described below.
  • MDH-25MB manufactured by Mitutoyo Corporation
  • the film has a laminated structure including a film prepared using the composition of the present disclosure and a waterproof/moisture-permeable layer described below, and the waterproof/moisture-permeable layer cannot be separated, a scanning electron microscope is used to measure the thickness-wise cross section of the laminated structure. The average thickness of at least five arbitrary locations on the film in the laminated structure can then be defined as the thickness of the film.
  • Films may also be defined by basis weight instead of thickness, where basis weight in this disclosure may be defined as weight (mg) per cm2 of film.
  • the basis weight of the film can be, for example, 0.0010 mg/cm 2 or more, 0.0060 mg/cm 2 or more, 0.010 mg/cm 2 or more, 0.025 mg/cm 2 or more, 0.035 mg/cm 2 or more, 0.050 mg/cm 2 or more, 0.070 mg/cm 2 or more, 0.10 mg/cm 2 or more, 0.15 mg/cm 2 or more, 0.30 mg/cm 2 or more, 0.45 mg/cm 2 or more, 0.70 mg/cm 2 or more, 1.0 mg/cm 2 or more, 3.0 mg/cm 2 or more, 5.0 mg/cm 2 or more, 7.0 mg/cm 2 or more, or 10 mg/cm 2 or more, and can be 100 mg/cm 2 or less, 50.0 mg/cm 2 or less, 30.0 mg/c
  • Films prepared using the compositions of the present disclosure, as well as films laminated with, for example, a moisture-permeable substrate and/or a waterproof/moisture-permeable layer as described below, can exhibit humidity responsiveness and can be used in a variety of applications.
  • Examples of applications for such films include cosmetics, medical applications (e.g., bandages, medical tapes), clothing, construction applications (e.g., wallpaper), and agricultural applications (e.g., films for vinyl greenhouses or plant cultivation).
  • medical applications e.g., bandages, medical tapes
  • clothing e.g., clothing
  • construction applications e.g., wallpaper
  • agricultural applications e.g., films for vinyl greenhouses or plant cultivation.
  • the humidity responsive film of the present disclosure may contain any constituent layer within a range that does not adversely affect the effects of the present invention.
  • such constituent layers may include, for example, a moisture-permeable adhesive layer (e.g., an adhesive layer having through holes), a protective film having peeling performance, a release sheet, etc.
  • the optional constituent layers may be used alone or in combination of two or more.
  • a protective film may be applied to one side of the humidity responsive film, and/or a release sheet may be applied to the opposite side.
  • the surfaces of the protective film and the release sheet may be subjected to a release treatment such as silicone.
  • the release performance of the protective film and the release sheet against the humidity responsive film may be the same or different. From the viewpoint of ease of peeling from the humidity responsive film, it is preferable that these release performances are different.
  • the material of the optional component layer is not particularly limited, and examples include polyolefins such as polyethylene and polypropylene, polyesters such as polyethylene terephthalate, cotton, and paper.
  • the optional component layer may be in the form of, for example, a film, or a nonwoven fabric, knitted fabric, or woven fabric.
  • the humidity-responsive film can be produced by using the above-mentioned composition for forming the humidity-responsive film.
  • the production method is not particularly limited, and for example, the composition can be applied to a release sheet or a moisture-permeable substrate by any known coating method such as offset printing, gravure coating, bar coating, knife coating, spray coating, etc., and the film can be continuously produced by optionally adopting, for example, a drying process, a process for applying any constituent layer, a winding process, etc.
  • the humidity-responsive film can also be produced discontinuously using the above-mentioned composition for forming a humidity-responsive film.
  • a predetermined amount of the composition is added to a container or mold, etc., and dried to prepare a film, and, as necessary, any constituent layer can be applied to the obtained film to produce the humidity-responsive film.
  • the composition can be put into, for example, a tube container or a spray container, and the composition can be applied from the container to a target site (e.g., a body surface or wall) and dried to form a humidity-responsive film directly at the target site.
  • kit The humidity-responsive film-forming composition of the present disclosure can be provided as a kit comprising such a composition and any optional components.
  • kits are not particularly limited, and examples thereof include components to which a waterproof and moisture-permeable layer can be applied, brushes, rollers, cutters, scissors, mirrors, etc.
  • the optional components can be provided in the kit alone or in combination of two or more types.
  • a “waterproof/moisture-permeable layer” refers to a layer that has waterproof properties and moisture permeability, and does not exhibit humidity responsiveness by itself.
  • the film formed by the composition is thin and the area to which the film is applied (e.g., body surface or wall) has a high moisture content, it may not be possible to prevent moisture from evaporating into the outside air even in a low humidity environment.
  • the area to which the film is applied e.g., body surface or wall
  • a waterproof/moisture-permeable layer between the film and the area to which the film is applied (e.g., body surface or wall)
  • the rigidity of the film itself increases, which may make it difficult to apply the film to the area where it is to be applied, such as the skin, and may also result in a poor appearance.
  • the outermost surface of the film is the surface used to adjust the moisture permeability to the external environment, so it is preferable that any of the above-mentioned constituent layers (e.g., waterproof moisture permeable layer or protective film) are not formed on this surface. Therefore, for example, when a waterproof moisture permeable layer is laminated on a humidity responsive film and used by applying it to the body surface, etc., it is preferable that the waterproof moisture permeable layer is configured to be positioned closer to the body surface than the humidity responsive film.
  • the waterproof and moisture permeable layer may be a single layer or a laminate.
  • the waterproof and moisture permeable layer may be in the form of a free-standing film or a non-free-standing film.
  • the waterproof and moisture permeable layer may be configured to be applied to the entire surface or a part of the humidity responsive film.
  • the waterproof and moisture-permeable layer is not particularly limited as long as it is a layer that can exhibit the above-mentioned humidity responsiveness when combined with the film formed from the composition.
  • the waterproof and moisture-permeable layer may be at least one selected from an oil layer, a polylactic acid layer, and an artificial skin.
  • Examples of materials for the oil layer include polar oils such as ester oils and non-polar oils such as hydrocarbon oils. Among these, non-polar oils are preferred from the standpoint of humidity responsiveness.
  • non-polar oils examples include petrolatum, liquid paraffin, tetraisobutane, hydrogenated polydecene, olefin oligomer, isododecane, isohexadecane, squalane, polybutene, hydrogenated polybutene, polyisobutene, hydrogenated polyisobutene, etc.
  • the non-polar oils can be used alone or in combination of two or more. Among them, petrolatum and liquid paraffin are preferred from the viewpoint of humidity responsiveness.
  • rubber or elastomers such as urethane rubber, olefin rubber, silicone rubber, acrylic rubber, and natural rubber, or ⁇ -gel can be used. These can be used alone or in combination of two or more. Among them, silicone rubber is preferred from the standpoint of flexibility, humidity responsiveness, etc.
  • the thickness of the waterproof and moisture-permeable layer is not particularly limited, and can be appropriately adjusted depending on the location where the waterproof and moisture-permeable layer is applied, the purpose of use, and the balance of humidity responsiveness when combined with the above-mentioned humidity-responsive film.
  • the waterproof/moisture-permeable layer can be specified, for example, by its basis weight.
  • the basis weight of the waterproof/moisture-permeable layer can be, for example, 1.0 mg/ cm2 or more, 1.2 mg/ cm2 or more, or 1.4 mg/ cm2 or more, and can be 2.0 mg/cm2 or less , 1.8 mg/cm2 or less , or 1.6 mg/ cm2 or less.
  • Optional components can be appropriately blended into the waterproof and moisture-permeable layer of the present disclosure as long as they do not adversely affect the effects of the present invention.
  • examples of such components include moisturizers, polymers, rubbers, elastomers, pressure-sensitive adhesives, adhesives, adhesion modifiers, adhesion modifiers, UV absorbers, antioxidants, preservatives, antioxidant assistants, light diffusing agents, fillers, skin nutrients, vitamins, various drugs applicable to pharmaceuticals, quasi-drugs, cosmetics, etc., organic powders, pigments, dyes, colorants, and fragrances.
  • the optional components can be used alone or in combination of two or more.
  • the composition of the present disclosure can be used in a cosmetic method.
  • a cosmetic method includes applying the composition of the present disclosure to a target site (e.g., a body surface).
  • a humidity-responsive film can be formed on the surface.
  • a film can, for example, release moisture from the skin to the outside air in a high humidity environment, and can reduce or suppress evaporation of moisture from the skin in a low humidity environment, so that the skin can be sufficiently moisturized even in a low humidity environment.
  • such a film can also have the effect of improving hair troubles such as split ends or broken hair in a low humidity environment.
  • the means for applying the composition to the target area can be carried out, for example, by painting the composition on the target area.
  • the means for applying the composition to the target area can be, for example, by spraying the composition onto the target area from a spray container containing the composition, or by putting the composition into a container without a spray function, taking an appropriate amount of the composition from the container onto a finger or the like, and spreading it over the target area.
  • a film obtained from the composition may be directly attached to the target area.
  • Target area There is no particular limit to the target site for applying the humidity-responsive film-forming composition of the present disclosure and the humidity-responsive film formed from the composition, and these can be applied to various sites.
  • target sites include sites made of materials such as resin, metal, concrete, ceramics, glass, wood materials, paper, and cloth. Sites made of such materials may be foamed or pores may be formed to impart moisture permeability, as necessary.
  • target sites may include any site on the body. Examples of such sites include the skin surface of the face (lips, eyes, nose, cheeks, forehead, etc.), neck, ears, hands, arms, legs, feet, chest, stomach, back, etc., or body hair such as hair, eyelashes, eyebrows, and beard.
  • the skin also includes nails that are hardened by changing the keratin of the epidermis of the skin.
  • the present invention will be described in more detail below with reference to examples, but the present invention is not limited to these. Unless otherwise specified, the blend amounts are indicated in mass %. Furthermore, the evaluation methods described in the examples are not limited to the compositions described in the examples and the films formed from the compositions, but can be similarly applied to the compositions described above and the films formed from the compositions.
  • the circular opening (radius: 0.7 cm, area: 1.54 cm2 ) of a vial containing 12 mL of water was covered with each measurement sample, and the vial was placed in a thermostatic chamber under predetermined temperature and humidity conditions. After being placed for 2 hours or more until the evaporation rate reached an equilibrium state where it was almost constant over time, the amount of water evaporation was measured after 10 hours or more had passed, and the transmittance was calculated under the following conditions of 28°C, 25% RH, 35% RH, 55% RH, 65% RH, and 75% RH using the following formulas 1 and 2.
  • w1 and w0 in formula 1 are the weights (g) of the measurement sample before and after the test, respectively
  • surface area is the surface area ( m2 ) of the film at the open part of the vial
  • time is the measurement time (h) of the water evaporation amount in the equilibrium state.
  • P inside and P outside in formula 2 are the internal pressure (Pa) inside the vial where the relative humidity can be assumed to be 100% and the external pressure (Pa) under the set humidity environment, respectively.
  • Test Example 1 Each sample in the present test examples was prepared according to the following method. In test example 1, the humidity response performance was examined when various polysaccharides were used. The results are shown in Table 1 and FIG.
  • Comparative Example 1 Filter paper #5A manufactured by ADVANTEC Co., Ltd. having a diameter of 21 mm was used as a measurement sample for Comparative Example 1.
  • Example 1 A composition for film preparation was prepared by mixing xanthan gum and ion-exchanged water in a 10 mL vial and stirring the mixture so that the concentration of the polysaccharide xanthan gum was 5.0% by mass. Next, 3.0 g of the composition obtained was added to a roughly circular petri dish having an area of 19.6 cm2 and dried to prepare a film having a basis weight of about 7.6 mg/ cm2 as a measurement sample.
  • Examples 2 to 11 Measurement sample films were prepared in the same manner as in Example 1, except that the polysaccharides were changed as shown in Table 1.
  • the basis weight of each of the obtained films was about 7.6 mg/ cm2 .
  • Test Example 2 Each sample in this test example was prepared according to the following method.
  • a component (sometimes simply referred to as "component under study") that improves humidity responsiveness when used in combination with a polysaccharide was studied.
  • the results are shown in Table 2 and FIG. 2.
  • the “mass ratio” in the tables of the present disclosure refers to the mass ratio of the component under study (humidity responsiveness improving component in the case of Table 3) to the polysaccharide.
  • the “reference comparative example” in Table 2 and FIG. 2 refers to a sample that contains polysaccharide and has humidity responsiveness, and therefore would normally be considered an example, but in which the effect of improving humidity responsiveness could not be confirmed when the polysaccharide and the component under study were used in combination.
  • Comparative Example 2 Filter paper #5A manufactured by ADVANTEC Co., Ltd. having a diameter of 21 mm was used as a measurement sample for Comparative Example 2.
  • Control 1 Evaluation Criteria Hydroxypropyl cellulose and ion-exchanged water were mixed in a 10 mL vial and stirred so that the concentration of the polysaccharide hydroxypropyl cellulose was 5.0% by mass to prepare a composition for film preparation. Next, 3.0 g of the obtained composition was added to a roughly circular petri dish having an area of 19.6 cm2 and dried to prepare a film having a basis weight of about 7.6 mg/ cm2 as a measurement sample.
  • Comparative Example 1 Hydroxypropyl cellulose, xylitol and ion-exchanged water were mixed in a 10 mL vial and stirred so that the concentration of the polysaccharide hydroxypropyl cellulose was 5.0% by mass and the mass ratio of xylitol to the polysaccharide was 0.5 to prepare a composition for film preparation. Next, 3.0 g of the obtained composition was added to a roughly circular petri dish with an area of 19.6 cm2 and dried to prepare a film with a basis weight of about 7.6 mg/ cm2 as a measurement sample.
  • Comparative Example 2 A measurement sample film was produced in the same manner as in Reference Comparative Example 1, except that the amount of xylitol was changed so that the mass ratio of xylitol to polysaccharides was 0.1. The basis weight of the obtained film was about 7.6 mg/ cm2 .
  • Test Example 3 Each sample in this test example was prepared according to the following method. In test example 3, it was examined whether the component (sometimes simply referred to as the "humidity responsiveness improving component") that was found to have an effect of improving humidity responsiveness in test example 2 also has an effect on other polysaccharides. Here, the results of Comparative Example 2, Control 1, and Examples 12, 14, and 18 in test example 2 are also shown in Table 3 and Figure 3 for reference.
  • the component sometimes simply referred to as the "humidity responsiveness improving component”
  • Examples 22 to 25 A measurement sample film was prepared in the same manner as in Reference Comparative Example 1 in Test Example 2, except that the polysaccharide and the component under test were changed to the polysaccharide and the humidity responsiveness improving component shown in Table 3.
  • the basis weight of the obtained film was about 7.6 mg/ cm2 .

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  • Chemical & Material Sciences (AREA)
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Abstract

La divulgation concerne : un régulateur d'humidité qui contient un composant d'origine naturelle et qui pourrait être utilisé pour préparer un film présentant une réactivité à l'humidité similaire à celle d'un film d'alcool polyvinylique, qui est un polymère synthétique dérivé du pétrole; et une composition filmogène sensible à l'humidité contenant ledit régulateur.　Un régulateur d'humidité selon la présente divulgation contient un polysaccharide, et une composition filmogène sensible à l'humidité selon la présente divulgation contient ledit régulateur d'humidité.
PCT/JP2024/037092 2023-11-02 2024-10-18 Régulateur d'humidité et composition filmogène sensible à l'humidité contenant ledit régulateur Pending WO2025094692A1 (fr)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088246A1 (fr) * 2001-04-26 2002-11-07 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Objet moule ayant une teneur de pullulane elevee, son procede de production et son utilisation
WO2009113435A1 (fr) * 2008-03-14 2009-09-17 Kaneko Tatsuo Préparation de dérivé de glucide
JP2011126844A (ja) * 2009-12-21 2011-06-30 Shiseido Co Ltd シート状化粧料
JP2015151394A (ja) * 2014-02-17 2015-08-24 コスメディ製薬株式会社 化粧用ゲルシート及びその製造方法
JP2015524836A (ja) * 2012-08-13 2015-08-27 ビーエーエスエフ ビューティ ケア ソリューションズ フランス エスエーエス 化粧品又は医薬品の保湿成分
JP2017193627A (ja) * 2016-04-20 2017-10-26 凸版印刷株式会社 湿度応答性透湿シートおよびその製造方法
JP2020128363A (ja) * 2019-02-08 2020-08-27 ロート製薬株式会社 皮膚外用組成物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088246A1 (fr) * 2001-04-26 2002-11-07 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Objet moule ayant une teneur de pullulane elevee, son procede de production et son utilisation
WO2009113435A1 (fr) * 2008-03-14 2009-09-17 Kaneko Tatsuo Préparation de dérivé de glucide
JP2011126844A (ja) * 2009-12-21 2011-06-30 Shiseido Co Ltd シート状化粧料
JP2015524836A (ja) * 2012-08-13 2015-08-27 ビーエーエスエフ ビューティ ケア ソリューションズ フランス エスエーエス 化粧品又は医薬品の保湿成分
JP2015151394A (ja) * 2014-02-17 2015-08-24 コスメディ製薬株式会社 化粧用ゲルシート及びその製造方法
JP2017193627A (ja) * 2016-04-20 2017-10-26 凸版印刷株式会社 湿度応答性透湿シートおよびその製造方法
JP2020128363A (ja) * 2019-02-08 2020-08-27 ロート製薬株式会社 皮膚外用組成物

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