WO2025088119A1

WO2025088119A1 - Modular application device

Info

Publication number: WO2025088119A1
Application number: PCT/EP2024/080228
Authority: WO
Inventors: Jürgen Rawert
Original assignee: Eyeneb GmbH
Current assignee: Eyeneb GmbH
Priority date: 2023-10-25
Filing date: 2024-10-25
Publication date: 2025-05-01
Anticipated expiration: 2026-04-25

Abstract

The invention provides for a device for the application of a liquid to a body surface of a subject by ejection of the liquid from the device towards the body surface, wherein the device is adapted to be releasably coupled to a portable electronic device and wherein the device comprises a base module and a replaceable module, wherein the replaceable module is adapted to be releasably connected to the base module. The invention further provides for a system comprising the device of the present invention and a portable electronic device. Furthermore, the invention provides for a replaceable module adapted to be releasably connected to a base module thereby forming the device of the present invention.

Description

TITLE: MODULAR APPLICATION DEVICE

Description

FIELD OF THE INVENTION

The present invention relates to devices for the application of a liquid such as a liquid for cosmetic or pharmaceutical purposes to a body surface of a subject, specifically to the surface of the skin or an ocular surface of a subject. More specifically, the invention relates to a modular application device as well as to a system comprising such modular application device and a portable electronic device such as a tablet computer or smartphone.

BACKGROUND OF THE INVENTION

Devices for the application of liquids to body surfaces of a subject may have a broad variety of application fields, especially however, may be used for decorative, cosmetic or pharmaceutical purposes. In these fields of application, it is common to apply liquids such as liquid compositions, ointments, makeup, pharmaceutical compositions and the like to a targeted area of the body surface of a subject including, but not limited to the skin, mucous membranes and others.

US 10,646,373 discloses an ejector device and method of delivering repeatable dosages to a subject for topical, oral, nasal, or pulmonary use. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

Due to the broad variety of application fields as well as due to the increasing need for the application of the abovementioned liquid preparations to body surfaces, for example, due to increasing stress exerted by environmental influences or advancements in the medical or pharmacological field, there is an increased demand for application devices that allow for application of liquids to a targeted body surface in an advantageous manner, for example with regard to economical but also environmental aspects. In view of this, it is highly desirable that such application devices can be provided to the user at low cost and in form that is easy to use as well as in a form that allows for the maximum avoidance of waste and other environmental impacts which usually increases the acceptance of such devices by the user.

It is thus an object of the present invention to provide for a device for the application of a liquid to a body surface of a user or subject, in particular to an ocular surface of a user or subject that can be provided to the user in a form that is very cost-effective, easy to use and that provides for a high user acceptance, also due to the avoidance of waste materials generated by the repeated use of such an application device. Further objects of the invention will be clear on the basis of the following description of the invention, examples and claims.

SUMMARY OF THE INVENTION

In a first aspect, the invention relates to a device for the application of a liquid to a body surface of a subject by ejection of the liquid from the device towards the body surface, wherein the device is adapted to be releasably coupled to a portable electronic device and wherein the device comprises a base module and a replaceable module, wherein the replaceable module is adapted to be releasably connected to the base module, the device comprising a reservoir for holding the liquid, an ejection unit for the ejection of the liquid, a pumping unit in fluid connection with the reservoir and the ejection unit and being adapted to convey the liquid from the reservoir to the ejection unit, a drive unit for driving the pumping unit, a control unit for controlling the ejection of the liquid, and a coupling unit for releasably coupling the device to the portable electronic device, and a receiving unit for releasably connecting the replaceable module with the base module; wherein the replaceable module of the device comprises the reservoir and the ejection unit.

In a second aspect, the present invention provides for a kit comprising the device according to the first aspect of the invention and instructions for use of the device.

In a third aspect, the invention provides for a replaceable module adapted to be releasably connected to the base module of the device according to the first aspect of the invention, the replaceable module comprising a reservoir for holding a liquid to be applied to a body surface of a subject by ejection of the liquid from the device towards the body surface, and an ejection unit for the ejection of the liquid.

In a fourth aspect, the invention provides for a kit comprising the replaceable module according to the third aspect of the invention and instructions for use of the replaceable module.

In a fifth aspect, the invention provides for a system for the application of a liquid to a body surface of a subject by ejection of the liquid from the device towards the body surface, wherein the system comprises: a) a device according to the first aspect of the invention, and b) a portable electronic device.

DESCRIPTION OF THE DRAWINGS

Fig. 1 depicts a schematic sideview representation of a system (200) comprising a modular application device (10) according to the present invention;

Fig. 2 depicts the present modular administration device (10) in the connected state; Fiig. 3 shows an alternative embodiment of the present modular application device (10) in the connected state;

Fig. 4 depicts an embodiment of modular device (10) in which the base module (20) and the replaceable module (30) are not connected to each other;

Fig. 5 shows an embodiment of the device (10) as depicted in Fig. 4 with the mechanical energy storage device (71) comprised by base module (20);

Fig. 6 depicts an embodiment of the present modular application device (10) in which the replaceable module (30) is not connected to the base module (20); and

Fig. 7 depicts the finally assembled system (200) comprising the present modular application device (10) with base module (20) connected to replaceable module (30) and the resulting device (10) in the connected state coupled to portable electronic device (1).

DETAILED DESCRIPTION OF THE INVENTION

The following terms or expressions as used herein should normally be interpreted as outlined in this section, unless defined otherwise by the description or unless the specific context indicates or requires otherwise:

The words “comprise”, “comprises” and “comprising” and similar expressions are to be construed in an open and inclusive sense, as “including, but not limited to” in this description and in the claims. In contrast to this, the terms "consist of", "consists of" and "consisting of" as used herein are so-called closed language meaning that only the mentioned components are present.

The terms “a” or “an” do not exclude a plurality; i.e. the singular forms “a”, “an” and “the” should be understood as to include plural referents unless the context clearly indicates or requires otherwise. In other words, all references to singular characteristics or limitations of the present disclosure shall include the corresponding plural characteristic or limitation, and vice versa, unless explicitly specified otherwise or clearly implied to the contrary by the context in which the reference is made. The terms “a”, “an” and “the” hence have the same meaning as “at least one” or as “one or more” unless defined otherwise.

The expressions, “one embodiment”, “an embodiment”, “a specific embodiment” and the like mean that a particular feature, property or characteristic, or a particular group or combination of features, properties or characteristics, as referred to in combination with the respective expression, is present in at least one of the embodiments of the invention. The occurrence of these expressions in various places throughout this description do not necessarily refer to the same embodiment. Moreover, the particular features, properties or characteristics may be combined in any suitable manner in one or more embodiments.

The terms “essentially”, “about”, “approximately”, “substantially” and the like in connection with an attribute or value include the exact attribute or the precise value, as well as any attribute or value typically considered to fall within a normal range or variability accepted in the technical field concerned. For example, the term “about” in connection with a value or range of values as used herein shall mean that such value or range of values includes typical deviations from such values of up to +/- 5% (abs.j, or up to about +/-4%, or up to +/- 3% up to +/- 2%, up to +/- 1%, up to +/- 0.5%.

In a first aspect, the present invention provides for a device for the application of a liquid to a body surface of a subject by ejection of the liquid from the device towards the body surface, wherein the device is adapted to be releasably coupled to a portable electronic device and wherein the device comprises a base module and a replaceable module, wherein the replaceable module is adapted to be releasably connected to the base module, the device comprising a reservoir for holding the liquid, an ejection unit for the ejection of the liquid, a pumping unit in fluid connection with the reservoir and the ejection unit and being adapted to convey the liquid from the reservoir to the ejection unit, a drive unit for driving the pumping unit, a control unit for controlling the ejection of the liquid, and a coupling unit for releasably coupling the device to the portable electronic device, and a receiving unit for releasably connecting the replaceable module with the base module; wherein the replaceable module of the device comprises the reservoir and the ejection unit.

The device according to this aspect of the invention (herein sometimes also referred to as “present device” or “application device”), in some embodiments, is suitable for the application of a liquid to a body surface of a subject by ejection of the liquid from the device towards the body surface, or, in other words, by topical application. Such application, in some embodiments may be a contactless application of the liquid to the body surface of the subject, whereas the term “contactless” as used herein means that the device or any of its constituents does not contact the body surface of the user during application of the liquid. Furthermore, the term “ejection” as used herein in connection with the liquid to be applied means that a continuous or discontinuous stream of such liquid or a one or more separate portions of such liquid is generated and conveyed towards the body surface, preferably in a pointed, or, in other words, targeted manner, whereas the stream or portions of liquid travel along a trajectory, preferably a pointed trajectory, from the ejection unit as described further below to the body surface of the subject to which the liquid is to be applied.

The term “subject” as used herein, unless otherwise stated, preferably refers to human or animal, preferably a warm-blooded animal, especially to a human.

The term “body surface” as used herein, unless otherwise stated, refers to a surface or specific surface area of the body of such subject, for example the surface of the skin or a specific area of the skin, a mucous membrane, a nail, a tooth, an eye or other surface area of the subject which is accessible for the application of a liquid from a location outside of the body without any penetration or surgical intervention necessary. In particular embodiments, the body surface of a subject is a surface of an eye of the subject, or in other words, an ocular surface, for example a sclera or a cornea of an eye of a subject. Such body surface may be intact, or diseased, such as damaged, inflamed or infected. The term “liquid” as used herein is to be understood in a broad sense and means, unless otherwise stated, a liquid or liquid composition comprising a liquid vehicle or solvent and at least one further ingredient dissolved or dispersed (for example in the form of a suspension or colloidal dispersion). In some embodiments, the liquid may be a physiologically acceptable liquid, for example a cosmetically or pharmaceutically acceptable liquid, preferably a pharmaceutically acceptable liquid. In some embodiments, the liquid may be an aqueous liquid or liquid composition comprising at least one of an excipient and an active pharmaceutical ingredient, for example an ophthalmic active pharmaceutical ingredient. The term “excipient” as used herein means, unless otherwise stated, means a substance that is formulated alongside with an active pharmaceutical ingredient in a pharmaceutical composition and includes, for example, salts, preservatives, antioxidants, buffers or pH-modifiers, viscosity enhancers, tonicity modifiers, surfactants, adjuvants, colorants and others. The term “active pharmaceutical ingredient” (API) as used herein means, unless otherwise stated, means a compound or combination of compounds which are pharmaceutically active against an undesired condition (of a subject). In particular embodiments, the liquid may be an ophthalmologically acceptable liquid for the (ophthalmic) application of the liquid to an ocular surface as discussed above. In particular embodiments, the liquid to be applied to a body surface, specifically to an ocular surface of a subject is provided in sterilized form.

In some embodiments, the liquid or the active pharmaceutically ingredients optionally comprised by the liquid to be dispensed by the device according to the present invention are suitable for the prevention, delay or treatment of an ophthalmic disease or disorder and for the topical administration to the eye of a subject in need thereof.

In some embodiments, the liquid may comprise a physiologically or pharmaceutically acceptable solvent for topical application, for example water, alcohols, for example ethanol, 2-propanol (isopropanol), glycerol or benzyl alcohol, glycols, especially 1,2- propanediol (propylene glycol), polyethylene glycols, mineral oils, paraffins, isopropyl myristate, oleic acid and others. In further embodiments, the liquid may comprise an ophthalmologically acceptable solvent, for example water, ethanol, glycerol, 1,2-propanediol, propylene glycol, polyethylene glycol, mineral oils, flaxseed oil, castor oil or mixtures thereof (for example compositions sometimes referred to as “artificial tears” which may comprise a demulcent such as carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (hypromellose), hydroxyethylcellulose, methylcellulose, dextran 70, gelatin, glycerol, polyethylene glycol (300, 400), polysorbate 80, polyvinyl alcohol and/or polyvinyl pyrrolidone (povidone)), either in the form of an aqueous mixture or solution or in non-aqueous form.

Furthermore, the term “liquid” as used herein is to be understood broadly to include liquids with a broad range of viscosities such as liquids with a very low viscosity in the range of, for example, from about 0.1 cP (centipoise) to about 1 cP as well as liquids with a very high viscosity in the range of, for example, from about 100 to about 200 cP. In some embodiments, the liquid to be dispensed by the device according to the present invention may have a viscosity in the range of from about 1 cP to about 100 cP or to about 75 cP or to about 60 cP (whereas 1 cP corresponds to 0.001Pa*s (pascal-second)).

The term “application” as used herein as used herein in connection with the term “liquid” means, unless otherwise stated, the activity of transferring such liquid onto a body surface of a subject or of bringing such liquid in contact with a body surface of a subject. In specific embodiments, especially in cases in which the liquid is a pharmaceutical liquid or liquid pharmaceutical composition, the term application” may also mean the administration, specifically the topical administration of such liquid or liquid pharmaceutical composition.

The device according to this aspect of the invention is adapted to be releasably coupled or, in other words, releasably “docked” to a portable electronic device. In some embodiments, the device according to this aspect of the invention is releasably couplable or, in other words, “dockable” to a portable electronic device.

The terms “releasably coupled” as used herein in connection with the device according to the present invention and the portable electronic device means, unless otherwise stated, that the present device can be coupled (or, in other words, attached or docked) to a portable electronic device by a releasable mechanical connection as described in further detail below in connection with the coupling unit of the device while the term “releasable” means that such connection, once established, may be released and re-established in a non-destructive manner. In some embodiments, such releasable mechanical connection results in an arrangement in which the present device and the portable electronic device are in a stable and defined position relative to each other. In some embodiments, the releasable coupling of the present application device to the portable electronic device allows for the for the transfer of data and/or energy between the application device and the portable electronic device as also described in further detail below.

The term “portable electronic device” as used herein may also be understood in a broad sense and may mean, unless otherwise stated, a tablet computer or smartphone, a (handheld) gaming console, a basic phone, a flip phone, a slider phone, a QWERTY phone, a rugged phone, a phablet, a folding phone, a netbook, a laptop computer, a digital media player, a handheld personal computer, a wearable computer, a smartwatch and others, preferably a tablet computer or a smartphone, especially a smartphone.

In some embodiments, the device of the present invention may be coupled to the portable electronic device by and a non-mechanical connection in order to establish a (wireless) connection between the device according to the invention and the portable electronic device in order to allow for the transfer of data and/or energy between the device according to the present invention and the portable electronic device.

As will be discussed in further detail below, the present administration device comprises a base module and a replaceable module, wherein the replaceable module is adapted to be releasably connected to the base module. The base module and the replaceable module, when connected to each other, form the application device according to the present invention in its operational state in which it allows for the application of the liquid to a body surface of a subject. It should be noted that either one of the base module and the releasable module alone or, in other words, disconnected from each other are not adapted to serve this purpose. In some embodiments, the base module or the replaceable module may have a separate housing. In further embodiments, both, the base module and the replaceable module has its own separate housing. This modular design allows for the advantageous allocation of the particular constituents and functional units as described further below in one of the two modules or in both modules, where applicable. The replaceable module is adapted or arranged for being releasably connected to the base module, thereby forming the device according to the present invention in a connected state (hereinafter referred to as “connected state”) or, in other words, in an operational state of the device in which the liquid can be applied to a body surface of a subject by ejection of the liquid from the device towards the body surface after being coupled to the portable electronic device as further discussed below. In particular embodiments, accordingly, the present device in the connected state comprising the base module and the replaceable module is not suitable for the application of liquid to a body surface unless coupled to the portable electronic device.

In some embodiments, in the connected state, the base module and the replaceable module are in an arrangement in which the base module and the replaceable module are in a stable and defined position relative to each other. Furthermore, in the connected state the base module and the replaceable module are in an arrangement, which allows for the operative interaction of the particular constituents or functional units of the present device, for example by mechanical, electro-mechanical and/or fluidic connections between the base module and the replaceable module and the corresponding constituents or functional units comprised by the respective modules. In this context as well the term “replaceable" means that such connection, once established, may be released and re-established in a non-destructive manner, if necessary repeatedly. To establish this connected state, as will be described in further detail below, at least one of the base module and the replaceable module comprises a receiving unit.

As a first functional unit, the device according to the present invention comprises a reservoir for holding the liquid. The term “reservoir” as used herein is to be interpreted broadly and refers to any type of disposable or reusable container that is suitable for holding the liquid to be applied to a body surface of a user by the present application device. In some embodiments, the reservoir may comprise a collapsible bag, such as a tube, or a container with at least one movable wall, a collapsible container such as a concertina-like container, or a dimensionally stable container, optionally with a gas exchange and ventilation opening. In some embodiments, the reservoir allows for the storage and withdrawal of the liquid in sterilized form, especially in cases in which the liquid is a pharmaceutically acceptable liquid to be applied to a damaged, diseased, inflamed or infected or intact body surface such as an ocular surface. In these embodiments, it may be advantageous that the container comprises a sterile filter in connection with an optional gas exchange and ventilation opening.

As discussed in further detail below, the reservoir is comprised by the replaceable module of the present device and may be provided in a form in which it can be removed and, if necessary, replaced within the replaceable module. In some embodiments, however, the reservoir is comprised by the replaceable module in a form in which it can only be replaced together with replaceable module, if necessary, for example when the liquid contained in the reservoir needs to be refilled or replaced.

In some embodiments, the reservoir has an inner volume or, in the case of a collapsible container, a maximum inner volume of up to about 10 mL, or up to about 7.5 or up to about 5 mL or up to about 2.5 mL, for example from about 0.1 mL or from about 0.2 mL to about 10 mL or to about 5 mL or to about 2.5 mL or to about 1 mL.

As a further functional unit, the device according to the present invention comprises an ejection unit for the ejection of the liquid, specifically for the ejection of the liquid towards the body surface of the subject. The ejection unit, in some embodiments, may be in fluidic connection with the reservoir via the pumping unit to allow for the ejection of the liquid pumped from the reservoir by the pumping unit towards the selected or, in other words, targeted body surface of a subject.

The ejection unit, in some embodiments, may be orientable to the body surface, for example an ocular surface of a subject to which the liquid is to be applied by the present application device. In some embodiments, the ejection unit is therefore used for targeted dispensing and application of liquid, preferably in the form of a continuous or discontinuous stream or separate dose or portion of liquid to the chosen body surface. In some embodiments, the ejection unit comprises a nozzle or an array of a plurality of nozzles for the ejection of the liquid, optionally in the form of a single fluid nozzle, for example a solid stream nozzle, a full or hollow cone nozzle, a nozzle with multiple exits, an impinging or non-impinging nozzle, a swirl nozzle or a nozzle plate, preferably a solid stream nozzle, a full or hollow cone nozzle. In some embodiments, the ejection unit may comprise a single nozzle or an array of a plurality of nozzles.

In some embodiments, the ejection unit comprises a nozzle that allows the liquid to leave the present application device at a certain speed, for example at a speed of from about 0.5 to about 10 m/s. This speed may be achieved by means of a pumping unit as described further below adapted to pump the liquid from the reservoir and to pressurize or accelerate the liquid. The pumping unit may comprise mechanical means such as a tensible spring or a pressurized container with valve, or else electrical means such as a pump or a vibrating mesh, that launches wetting liquid. Orientation is achieved in the simplest case by manual movement of the entire present device, especially in the coupled state along with the portable electronic device by the user, but can also be achieved jointly with a few components thereof, or by separate orientation of merely the dispensing unit, and here in particular the nozzle or the nozzle array.

As a further functional unit, the modular application device according to the present invention comprises a pumping unit in fluid connection with the reservoir and the ejection unit and being adapted to pump or, in other words, convey the liquid from the reservoir to the ejection unit, specifically in the connected state of the present device in which the base module is connected to the replaceable module. The term “pumping unit” as referred to herein is to be understood in a broad sense and means, unless otherwise stated a functional unit which allows to accelerate or convey the liquid from the reservoir to the ejection unit and furthermore to eject the liquid from the ejection unit towards the targeted body surface if the subject.

In some embodiments, the pumping unit may comprise a pump, for example a mechanical or electromechanical pump. In some embodiments the pump may be a check-valve pump, a peristaltic pump, a rotary pump, a valveless rectification pump or an ultrasonic pump. In further embodiments, the pump may be a non-mechanical pump, for example an electrohydrodynamic pump, an electrokinetic pump, a phase transfer pump or a magnetohydrodynamic pump. In some embodiments, the pumping unit may comprise other pump systems like syringe-like pump systems, screw pumps, gear pumps, heat-based pumps or piezo electric pumps or pumps comprising a vibrating mesh or membrane. In yet further embodiments, the pumping unit comprises a pump selected from the group consisting of electromechanical pumps, piezo pumps, piston pumps and mechanical pumps. In further embodiments, the pumping unit may comprise a pump adapted for generating a continuous or nonconstant stream of the ejected liquid. In alternative embodiments, the pumping unit comprises a pump adapted for generating and conveying discrete portions of the liquid. In particular embodiments, the pumping unit comprises a piston pump, more specifically a piston pump comprising a piston for movement within a hollow cylinder such as a syringe-type pump.

The pumping unit may further comprise further mechanical or fluidic elements as necessary to allow the pump to pressurize, accelerate or convey the liquid as described above, for example, fluidic connections in the form of liquid-tight tubing, valves or other microfluidic elements.

As a further functional unit, the device according to the present invention comprises a drive unit for driving the pumping unit. The drive unit as referred to herein may provide the pumping unit as described above or, more specifically the pump comprised by such pumping unit with sufficient energy, for example kinetic or electric energy to exert its pumping activity. In some embodiments, the drive unit may comprise a motor, for example an electrical motor or a mechanical energy storage device. Furthermore, the drive unit may comprise means for transferring the energy to be supplied to the pumping unit, specifically the kinetic energy or the electric energy to the pumping unit, for example circuitry for the transfer of electrical energy or mechanical means such as plungers, shafts, joints, gears and the like for the transfer of kinetic energy.

In some embodiments, the drive unit comprises a mechanical energy storage device or, in other words, a device adapted for the storage and release of energy. In some embodiments, the mechanical energy storage device may be adapted to store energy in the form of potential energy and to release such energy partially or entirely, for example in the form of kinetic energy. In particular embodiments, the mechanical energy storage device comprises at least one of a deformable elastic element, for example a spring, a reservoir for a compressed gas and a gas generating unit. In further particular embodiments, the term deformable elastic element may be interpreted broadly and may comprise, for example as spring, such as a leave spring or spiral spring which both may comprise or consist of an elastic material such as a metal, for example steel, or an elastomeric material, for example a polymeric elastomeric material. In yet further particular embodiments, such deformable elastic element may be an elastic body in a form or shape different from a spring, for example in the form of an elastic block or cylinder which, for example, may comprise an elastomeric material.

In yet further particular embodiments, the mechanical energy storage device may be in the form of a reservoir holding a compressed gas and may further comprise a valve for the partial or entire release of the compressed gas in order to generate kinetic energy.

In yet further particular embodiments, the mechanical energy storage device may comprise a gas generating unit, for example, a miniaturized unit for the electrochemical generation of a gas such as hydrogen which may be used to drive the pumping unit of the present application device.

As a further functional unit, the device according to the present invention comprises a control unit for controlling the ejection of the liquid. The term “control unit” as used herein is to be understood in a broad sense as a unit which is adapted or arranged or suitable for controlling the processes necessary for the implementation of the ejection of the liquid from the present device towards the targeted body surface, specifically the process of controlling or monitoring the pumping unit, specifically the controlling or monitoring of the pump comprised by the pumping unit and the associated drive unit as described above. Furthermore, the control unit may electronically cooperate and communicate with the portable electronic device to which the present application device is coupled (in the coupled state). In further embodiments, the control unit may provide for the electronic connection between the portable electronic device (in the coupled state) and the drive and pumping unit and potentially further functional units of the present application device. In some embodiments, the control unit may comprise suitable and, in some embodiments, miniaturized circuitry such as one or more printed circuit bords (PCBs) equipped with electronic components such as transistors, diodes, integrated circuits, processors, electronic storage devices, for example electronic data storage devices, optoelectronic devices, sound generators and other known to those of skill in the art.

As a further functional unit, the device according to the present invention comprises a coupling unit for releasably coupling the present modular application device to the portable electronic device. The term “coupling unit” as used herein is also to be understood in a broad sense as a functional unit adapted or suitable for establishing a releasable connection between the present device and the portable electronic device, wherein the term “releasable” as used in this context means that such connection may be formed and released and, if necessary, formed again in a non-destructive manner. In some embodiments, the coupling unit comprises coupling means adapted to form a releasable connection, preferably a releasable electro-mechanic connection between the base module and the portable electronic device (in the coupled state). In specific embodiments, the coupling unit may be comprised by the base module of the present device and, in further specific embodiments, may not be comprised by the replaceable module of the device.

In further embodiments, the coupling device may be adapted for the transfer of data and/or energy between the portable electronic device and the present modular application device and may be provided in the form of a mechanical connection, specifically in the form comprising a plug connection. In some embodiments, plug connectors may be provided that allow for both, the transfer of data and energy in both directions between the portable electronic device and the present modular application device. Suitable plug connectors in this regard comprise but are not limited to, for example, interfaces of the USB-type, especially micro-USB and USB-C as well as Lightning®. Accordingly, in particular embodiments, the coupling unit may comprise USB or Lightning connectors, specifically USB-C connectors. In specific embodiments, such corresponding Lightning or USB-C connectors may be provided on the portable electronic device as well as on the present application device, specifically the base module of the present application device. In this regard, however, it should be noted that the connectors as referred to herein may be replaced by future connectors suitable for the exchange of data and/or energy, accordingly.

In specific embodiments, the present modular application device, specifically the base unit thereof may comprise a male (USB, USB-C or Lightning) connector and the portable electronic device may comprise a female (USB, USB-C or Lightning) connector. Accordingly, in particular embodiments, the coupling unit of the present modular application device may be adapted to form a releasable connection between the base module of the device and the portable electronic device comprise a plug connector, preferably a male connector (USB-C, Lightning, micro-USB).

In some embodiments, the coupling unit may comprise means for establishing a mechanical connection between the portable electronic device and the present modular application device, specifically the base module thereof and may furthermore comprise means for establishing a wireless electronic connection between the portable electronic device and the present modular application device, specifically the base module thereof. In these embodiments, the term “mechanical connection” is to be understood as a connection between the portable electronic device and the present modular application device, specifically the base module thereof, in which the portable electronic device and the present modular application device, specifically the base module thereof, are in a positionally stable relationship to each other such that the portable electronic device and the present modular application device can be operated by a user as one single unit or system (in the coupled state). Furthermore, in these embodiments, the portable electronic device and the present modular application device may be connected to each other for the exchange of data and/or energy by a wireless connection, for example by a Bluetooth®, WLAN or other near-filed connection (NFC) or suitable future wireless connections.

As a further functional unit, the device according to the present invention comprises a receiving unit for releasably connecting the replaceable module with the base module. The receiving unit of the present modular application device is provided in order to establish a releasable connection between the base module and the replaceable module by which the present modular application device is formed in its connected state or, in other words, in a state in which it can be operated by a user for the application of a liquid to a targeted body surface after being coupled to the portable electronic device (thereby forming the device of the present invention in the operational state). In some embodiments, the receiving unit may be (partly) comprised by both, the receiving unit of the base module and the replaceable module.

In some embodiments, the receiving unit of the base module and the replaceable module comprise corresponding connecting means adapted to form a releasable connection, preferably a releasable electro-mechanical and/or mechanical connection and/or fluidic connection between the base module and the replaceable module of the device. In this context as well, the term “releasable” may mean that such connection may be formed and released and, if necessary, formed again in a nondestructive manner. In some alternative embodiments, however, in this context the term “releasable” may mean that such connection may be formed and released only once and that, in other words, such replaceable module may only be connected (and disconnected) once to or from the base module. In some embodiments, the base module and the replaceable module in the connected state form a mechanically stable assembly or, in other words, an assembly in which both modules are in a positionally stable relationship to each other. This may be implemented, for example, by a broad variety of suitable connecting means provided on either one or both of the base module and the replaceable module, for example by a form-fit or force-fit or snap-fit connection such as by corresponding plug connectors, fastening rails, hooks with corresponding eyelets, magnetic connectors or even hook and loop connectors (Velcro® connectors) which may be, for example provided, on the outer surface of the corresponding housings of the base module and the replaceable module.

According to the present invention, the replaceable module of the present modular application device comprises the reservoir and the ejection unit. It has been found by the inventors that the modular design of the present application device allows for the maximum flexibility and particularly advantageous designs of the present device especially in case in which the replaceable module comprises both the reservoir and the ejection unit as both described in detail above. This has been proven especially advantageous in connection with the general functional layout of the device as being adapted to form a functional assembly or system with a portable electronic device which offers the possibility to co-operate with and share technical resources and capabilities between the portable electronic device and the present modular application device. For example, either one of or a subset of all of the following elements of the portable electronic device may be used or co-used by the present modular application device, for example the CPU, the reloadable battery, the display, the camera(s), other sensors such as position sensors, temperature sensors, humidity sensors, vibrating elements, the microphone, the loudspeaker and/or identification means.

The specific design of the present modular application device having the reservoir and the ejection unit comprised by the replaceable module allows for the advantageous design in which both, the reservoir and the ejection unit can be replaced along with the replaceable unit, for example, when the reservoir is empty and needs to be exchanged by a corresponding replacement module having a filled or partially filled reservoir. Furthermore, this design allows for the use of a particular base unit with different exchangeable units comprising different liquids to be applied to a body surface. Especially due to the fact that an ejection unit is often specifically designed with regard to the physico-chemical properties of a specific liquid or constituents contained therein, such as density, viscosity, specific chemical parameters such as pH-values and others, in many cases a specific ejection unit is used with a particular liquid and, accordingly, has to be exchanged when switching to a different liquid to be applied. Furthermore, the integration of ejection unit and reservoir within the replaceable module allows to reduce the risk of crosscontaminations with different liquids which is especially relevant in the field of the application of pharmaceutical liquids. In particular embodiments, the replaceable module is (initially) provided in sterilized form. In yet further embodiments, the replaceable module is (initially) provided in individually packaged form, for example sealed by a foil or blister pack.

In some embodiments, the functional units other than the reservoir and the ejection unit may be comprised by or, in other words, allocated in either one of the base module and the replaceable module as outlined in further detail below, or, in some embodiments may be comprised by both, the base module and the replaceable module. In some embodiments, the base module of the present modular application device may comprise the control unit and the coupling unit as described above. In further embodiments, the base module of the present modular application device may comprise the control unit the coupling unit and the receiving unit. In yet further embodiments as already described above, however, the receiving unit may be comprised by both, comprise the base module and the replaceable module.

In some embodiments, the base module may also comprise the pumping unit comprising the pump as described in detail above. In further embodiments, the pumping unit may be comprised by the base unit and is not comprised by the replaceable unit. In these embodiments, accordingly, the pump unit is not replaced once the replaceable module of the present application device is replaced and can be used repeatedly, independent of the exchange of the replaceable unit. This allows for economically advantageous embodiments of the present application device, especially in cases in which technically or mechanically complex and, accordingly, expensive pumping units are to be implemented, for example pumping units comprising an electrohydrodynamic pump, an electrokinetic pump, a phase transfer pump or a magnetohydrodynamic pump, a peristaltic pump, a piezoelectric pumps or others.

In alternative embodiments, however, the replaceable module comprises the pumping unit. In further embodiments, the pumping unit may be comprised by the replaceable module and not by the base module. In these embodiments, accordingly, the pump unit is replaced once the replaceable module of the present application device is replaced and, accordingly, cannot be used repeatedly. This design allows for advantageous embodiments of the present application device in which the reservoir, the pumping unit and the ejection unit are replaced when the replaceable module is replaced or exchanged by another replaceable module. In further embodiments, the replaceable module further comprises tubing for the fluidic connection of the reservoir with the ejection unit.

In yet further embodiments, the replaceable module comprises all components that are contact with the liquid (under standard operating conditions). Especially in these embodiments, the present modular application device allows for the exchange of the replaceable module along with all components which (under standard operating conditions) are in contact with the liquid to be applied to a body surface of a subject. This, however, is especially advantageous in cases in which liquids are to be ejected and applied to a body surface which are sensitive to cross-contamination, or which have to be applied in very pure or even sterile form as it is the case for many cosmetic or pharmaceutical applications. In these embodiments, it has been proven advantageous, if the pumping unit, specifically the pump of the pumping unit has a lower technical complexity such that it can be provided in an economically advantageous form as it is the case, for example, for piston pumps, reversed piston pumps, syringe-type pumps or other pressure-based delivery systems in general, especially piston pumps and syringe-type pumps.

In some embodiments, the base module may also comprise the drive unit as described in detail above. In further embodiments, the drive unit is comprised by the base unit and is not comprised by the replaceable unit. In these embodiments, accordingly, the drive unit is not replaced once the replaceable module of the present application device is replaced and can be used repeatedly, independent of the exchange of the replaceable unit. This allows for economically advantageous embodiments of the present application device, especially in cases in which technically or mechanically complex and, accordingly, expensive drive units are to be implemented, for example electrical drive units such as electrical motors.

In alternative embodiments, however, the replaceable module comprises the drive unit. In further embodiments, the drive unit may be comprised by the replaceable module and not by the base module. In these embodiments, accordingly, the drive unit is replaced once the replaceable module of the present application device is replaced and, accordingly, cannot be used repeatedly. This design allows for advantageous embodiments of the present application device, especially when the drive unit comprises a mechanical energy storage device as discussed in detail above, such as deformable elastic element, for example a spring. In some embodiments, the energy storage device may be comprised by the replaceable module.

In these embodiments, the mechanical energy storage device may be charged with (potential) energy, for example by deformation, compression or extension of the mechanical energy storage device, for example when the replaceable module is inserted, introduced or attached to the base module. In these advantageous embodiments no additional electrical or mechanical storage device would be necessary to provide the energy necessary for driving the pump of the pumping unit. In some embodiments, the exchangeable module may be provided in a form, in which the mechanical energy storage is already loaded with energy or, in other words, is provided in a loaded state. In these embodiments, after connection of the releasable module with the base module the resulting device is ready for use without the need of further loading or charging the mechanical energy storage device.

In alternative embodiments, however, it is also possible to provide for a separate priming unit to prime the drive unit or, in other words, to introduce energy to the drive unit, specifically the mechanical energy storage device such as a spring or other elastic element as described above, whereas such priming unit may be comprised by either one or both of the base unit and the replaceable unit, preferably, however, by the base unit. In particular embodiments, the replaceable module may comprise a mechanical energy storage, for example in the form of a spring, and the base unit may comprise a priming unit for priming or tensioning the spring prior to use.

In particular embodiments, especially in cases in which the drive unit comprises a mechanical energy storage device, the replaceable module may comprise the energy storage device, the pumping unit, preferably comprising a piston pump, the reservoir and the ejection unit. This co-location of the mechanical energy storage device, pumping unit, reservoir and ejection unit allows for the advantageous alignment of the specific parameters of these functional units with regard to a specific liquid and specific amount thereof to be dispensed, for example regarding different sizes or volumes of the reservoir, different (spring) forces depending on the volume or viscosity of the specific liquid and/or different designs of the ejection unit and nozzle.

In further particular embodiments, the replaceable module may comprise a closing cap to protect the ejection unit in a non-use state.

In some embodiments, the present modular application device may further comprise indicating means for indicating the tensioning/loading state of the drive unit. In some embodiments, such indicating means may comprise a display or optical indicator. Such indicating means may also be provided on either one or both of the base module and the replaceable module, preferably however, on the particular module which also comprises the respective energy storage device, preferably the mechanical energy storage device, if present. Accordingly, in some embodiments, the base module comprises the indicating means. In alternative embodiments the exchangeable module comprises the drive unit and the indicating means.

In further embodiments, the present modular device comprises means for identifying the replaceable module in the connected state of the base module and the replaceable module. Such identifying means may be comprised by the either one of the base module and the replaceable module or, in some embodiments, may be comprised (partly) by both, the base unit and the replaceable unit. In some embodiments, such means are suitable for at least one of a) identifying the replaceable module and b) providing information related to the liquid comprised by the reservoir of the exchangeable module, for example related to the constituents of the liquid, amount and/or concentration of liquid comprised, data related to the manufacture, expiration dates and others. In some embodiments, the identifying means may be, for example, in the form specific patterns provided on (the surface) of the exchangeable module that may be read by a corresponding sensor on the base pattern. In other embodiments, such identifying means may comprise a device for the storage of electronic data that may be read by a corresponding reading device, either via a wired or contactless connection. In particular embodiments, the replaceable module may comprise a data storage device, for example an RFID chip, and the base module may comprise a corresponding RFID reader. On the basis of the data provided accordingly, in some embodiments, the specific commands necessary for the ejection of the liquid to the targeted body surface may be calculated by the control unit and provided to the other units as described above, specifically the drive unit and the pumping unit. In some embodiments such calculation by the drive unit may comprise an interaction between the control unit and the portable electronic device as described in further detail below.

The modular application device of the present invention may be provided along with directions for the use of the device, including but not limited to the connection and disconnection of the replaceable module to the base module, the coupling of the base module to a portable electronic device as well as other instructions for use of the device, specifically with regard to the intended application of the liquid to a targeted body surface.

Accordingly, in a second aspect, the present invention provides for a kit comprising the device according to the first aspect of the invention and instructions for use of the device.

For the avoidance of doubt and in order to prevent repetitions it should be noted that all embodiments, features, explanation and combinations thereof as described herein in connection with the modular application device according to the first aspect of the invention apply to this second and all further aspects, and vice versa.

In a third aspect, the present invention provides for a replaceable module adapted to be releasably connected to a base module thereby forming the modular application device according to the first aspect of the invention, the replaceable module comprising: a reservoir for holding a liquid to be applied to a body surface of a subject by ejection of the liquid from the device towards the body surface, and an ejection unit for the ejection of the liquid (towards the body surface of the subject).

In some embodiments, the replaceable module according to this aspect of the invention may further comprise a pumping unit in fluid connection with the reservoir and the ejection unit, the pumping unit being adapted to convey the liquid from the reservoir to the ejection unit (in the connected state). In further embodiments, the replaceable module further comprises a drive unit for driving the pumping unit. In yet further embodiments, the replaceable module may be provided in sterilized form and/or in individually packaged form, for example sealed by a foil or blister pack. In some embodiments, the replaceable module may comprise means for identifying the replaceable module as described in detail above in connection with the modular device of the first aspect of the invention.

The replaceable module according to this aspect may also be provided along with directions for the use of the replaceable module, including but not limited to the connection and disconnection of the replaceable module to the base module, as well as other instructions for use of the device, specifically with regard to the intended application of the liquid to a targeted body surface.

Accordingly, in a fourth aspect the invention provides for a kit comprising the replaceable module according to the third aspect of the invention and instructions for use of the replaceable module.

The present modular application device as described in connection with the first aspect of the invention may be coupled to a portable electronic device via the coupling unit as described in detail above to form an assembly or system comprising the present modular administration device and the portable electronic device in a positionally stable arrangement in which it can be used, handled and manipulated as a single assembly by a user for the application of the liquid to a targeted body surface, such as an ocular surface of a subject. In this context, it should be noted that, in some embodiments, said user may be identical to the subject to which the liquid is applied. In alternative embodiments, however, however, such user as referred to above may be different from the subject to which the liquid is applied.

Accordingly, in a fifth aspect, the present invention provides for a system for the (contactless) application of a liquid to a body surface of a subject by ejection of the liquid from an application device towards the body surface, wherein the system comprises: a) the device according to the first aspect of the invention, and b) a portable electronic device.

In particular embodiments, as outlined in connection with the first aspect of the invention already, the portable electronic device may be a tablet computer or smartphone, a (handheld) gaming console, a basic phone, a flip phones, a slider phone, a QWERTY phone, a rugged phone, a phablet, a folding phone, a netbook, a laptop computer, a digital media player, a handheld personal computer, a wearable computer, a smartwatch and others, preferably a tablet computer or a smartphone, especially a smartphone.

As also outlined in connection with the first aspect, such portable electronic device may be releasably coupled to the modular device of the first aspect, specifically to the base module of the modular device, via the coupling unit of the device and in the coupled state, data and/or energy may be transferred from the electronic mobile device to the (base module) of the modular application device and vice versa. This design allows for the use and cooperation of the technical resources of the portable electronic device, for example the processor(s), the data storage, the battery, sensors, such as the camera(s), sensors, for example, sensors for the position or location, acceleration, temperature and others, the display and other functional elements in the finally assembled state. This contributes to the overall advantageous design of the modular application device of the present invention in which a large number of technical elements can be provided by a (reusable) portable electronic device and in which a further considerable number of technical elements are comprised by a (reusable) base module and in which only a small number of technical elements is comprised by a (non-reusable, disposable) replaceable module. Furthermore, this overall design allows for maximum flexibility also with regard to the specific liquid to be applied or, in other words, allows for abroad variety of different liquids and application purposes to be performed with the same components of the system, specifically with the same portable electronic device and the same base module of the present modular application device. This, however, is not only especially advantageous with regard to economic but also with regard to environmental considerations.

In some embodiments, in order to provide for a defined spatial relationship between the portable electronic device and the present modular application device in the coupled state, the modular application device, specifically the base module of the modular application device, may comprise means for determining the position of the base module in relation to the portable electronic device (in the coupled state). In some embodiments, such means for determining the position of the base module in relation to the portable electronic device (in the coupled state) may comprise, for example a stylus or a plurality of styluses adapted to interact with the touch-sensitive screen of the portable electronic device, preferably the smartphone or tablet computer. The following is a list of exemplary numbered embodiments El to E40 comprised by the present invention:

El. A device (10) for the (contactless) application of a liquid (L) to a body surface (S) of a subject by ejection of the liquid (L) from the device (10) towards the body surface, wherein the device (10) is adapted to be releasably coupled to a portable electronic device (1) and wherein the device (10) comprises a base module (20) and a replaceable module, wherein the replaceable module (30) is adapted to be releasably connected to the base module (20) (in a connected state of the device), the device (10) comprising a reservoir (40) for holding the liquid (L), an ejection unit (50) for the ejection of the liquid (L) (towards the body surface of the subject), a pumping unit (60) in fluid connection with the reservoir (40) and the ejection unit (50) and being adapted to convey the liquid (L) from the reservoir (40) to the ejection unit (50) (in the connected state), a drive unit (70) for driving the pumping unit (60), a control unit (80) for controlling the ejection of the liquid (L), a coupling unit (90) for releasably coupling the device (10) to the portable electronic device (1), and a receiving unit (100) for releasably connecting the replaceable module (30) with the base module (20); wherein the replaceable module (30) of the device comprises the reservoir (40) and the ejection unit (50).

E2. The device (10) according to embodiment El, wherein the body surface of a subject is a surface of an eye of the subject.

E3. The device (10) according to embodiment El or E2, wherein the liquid (L) is a cosmetically or pharmaceutically acceptable liquid, preferably a pharmaceutically acceptable liquid.

E4. The device (10) according to any one of the preceding embodiments, wherein the liquid (L) is an aqueous liquid or liquid composition comprising at least one of an excipient and an active pharmaceutical ingredient, for example an ophthalmic active pharmaceutical ingredient.

E5. The device (10) according to any one of the preceding embodiments, wherein the liquid (L) is in sterilized form.

E6. The device (10) according to any one of the preceding embodiments, wherein the base module (20) of the device (10) comprises the control unit (80), the coupling unit (90) and the receiving unit (100).

E7. The device (10) according to any one of the preceding embodiments, wherein the replaceable module (30) comprises the pumping unit (60).

E8. The device (10) according to any one of the preceding embodiments, wherein the base module (20) comprises the drive unit (70).

E9. The device (10) according to any one of embodiments El to E7, wherein the replaceable (30) module comprises the drive unit (70).

E10. The device (10) according to any one of the preceding embodiments, wherein the replaceable (30) module comprises the drive unit (70).

Ell. The device (10) according to any one of the preceding embodiments, wherein the ejection unit (50) comprises a nozzle (51) for the ejection of the liquid (L), optionally in the form of a single fluid nozzle, for example a solid stream nozzle, a full or hollow cone nozzle, a nozzle with multiple exits, an impinging or non-impinging nozzle, a swirls nozzle or a nozzle plate.

E12. The device (10) according to any one of the preceding embodiments, wherein the pumping unit (60) comprises a pump (61) adapted for generating and conveying discrete portions of the liquid (L).

E13. The device (10) according to any one of the preceding embodiments, wherein the pumping unit (60) comprises a pump (61) selected from the group consisting of electromechanical pumps, piezo pumps, piston pumps and mechanical pumps.

E14. The device (10) according to any one of the preceding embodiments, wherein the pumping unit (60) comprises a piston pump (61). E15. The device (10) according to any one of the preceding embodiments, wherein the replaceable module (30) further comprises tubing (31) for the fluidic connection of the reservoir with the ejection unit.

E16. The device (10) according to any one of the preceding embodiments, wherein the replaceable module (30) comprises all components that are contact with the liquid (L) (under standard operating conditions).

E17. The device (10) according to any one of the preceding embodiments, wherein the replaceable module (30) is (initially) provided in sterilized form.

E18. The device (10) according to any one of the preceding embodiments, wherein the replaceable module (30) comprises a closing cap (32) to protect the ejection unit (50) in a non-use state.

E19. The device (10) according to any one of the preceding embodiments, wherein the drive unit (70) comprises a motor or a mechanical energy storage device [71).

E20. The device (10) according to any one of the preceding embodiments, wherein the drive unit (70) comprises a mechanical energy storage device (71).

E21. The device (10) according to embodiment E20, wherein the mechanical energy storage device (71) comprises at least one of a deformable elastic element (e.g. a spring), a reservoir for a compressed gas and a gas generating unit.

E22. The device (10) according to embodiment E20 or E21, wherein the energy storage device (71) is comprised by the replaceable module (30).

E23. The device (10) according to any one of embodiments E20 to E22, wherein the replaceable module (30) comprises the energy storage device (71), the reservoir (40) the pumping unit (60), preferably comprising a piston pump (61), and the ejection unit (50).

E24. The device (10) according to any one of the preceding embodiments, wherein the receiving unit (100) of the base module (20) and the replaceable module (30) comprises corresponding connecting means (101) adapted to form a releasable connection, preferably a releasable electro-mechanical and/or mechanical and/or fluidic connection between the base module (20) and the replaceable module (30) of the device (10).

E25. The device (10) according to any one of the preceding embodiments, wherein the base module (20) and the replaceable module (30) in the connected state form a mechanically stable assembly.

E26. The device (10) according to any one of the preceding embodiments, wherein the coupling unit (90) comprises coupling means (91) adapted to form a releasable connection, preferably a releasable electro-mechanic connection between the base module (20) and the portable electronic device (1) (in the coupled state).

E27. The device (10) according to embodiment E26, wherein the coupling means (91) are adapted to form a releasable connection between the base module (20) of the device (10) and the portable electronic device (1) comprise a plug connector, preferably a male connector (USB-C, Lightning, micro-USB).

E28. The device (10) according to any one of the preceding embodiments, wherein the base module (20) comprises means for determining the position (21) of the base module (20) in relation to the portable electronic device (1) (in the coupled state).

E29. The device (10) according to embodiment E28, wherein the means for determining the position (21) of the base module (20) in relation to the portable electronic device (1) (in the coupled state) comprise a stylus adapted to interact with the touch-sensitive screen (2) of the portable electronic device (1), preferably the smartphone or tablet computer.

E30. The device (10) according to any one of the preceding embodiments, wherein the device (10) comprises means for identifying the replaceable module (30) in the connected state of the base module (20) and the replaceable module [30).

E31. A kit comprising the device (10) according to any one of the preceding embodiments and instructions for use of the device (10). E32. A replaceable module (30) adapted to be releasably connected to a base module (20) thereby forming the device (10) according any one of embodiments El to E30, the replaceable module (30) comprising: a reservoir (40) for holding a liquid (L) to be applied to a body surface (S) of a subject by ejection of the liquid (L) from the device [10] towards the body surface (S), and an ejection unit (50) for the ejection of the liquid (L) (towards the body surface of the subject).

E33. The replaceable module (30) according to embodiment E32, wherein the replaceable module (30) further comprises a pumping unit (60) in fluid connection with the reservoir (40) and the ejection unit (50) and being adapted to convey the liquid (L) from the reservoir (40) to the ejection unit (50) (in the connected state).

E34. The replaceable module (30) according to embodiment E32 or E33, wherein the replaceable module (30) further comprises a drive unit (70) for driving the pumping unit (60).

E35. The replaceable module (30) according to any one of embodiments E32 to E34, wherein the replaceable module (30) is provided in sterilized form.

E36. The replaceable module (30) according to any one of embodiments E32 to E35, wherein the replaceable module (30) is provided in individually packaged form.

E37. The replaceable module (30) according to any one of embodiments E32 to E36, wherein the replaceable module (30) comprises means for identifying the replaceable module (30).

E38. A kit comprising the replaceable module (30) according to any one of embodiments E32 to E37 and instructions for use of the replaceable module [30).

E39. A system (200) for the (contactless) application of a liquid (L) to a body surface (S) of a subject by ejection of the liquid (L) from an application device (10) towards the body surface (S), wherein the system (200) comprises: a) the device (10) according to any one of embodiments El to E30, and b) a portable electronic device (1).

E40. The system (200) according to embodiment E39, wherein the portable electronic device (1) is a tablet computer or smartphone, preferably a smartphone.

DETAILED DESCRIPTION OF THE DRAWINGS

Figure 1 shows a schematic sideview representation of a system (200) comprising a modular application device (10) according to the present invention comprising a base module (20) and a replaceable module (30). In the embodiment shown, the replaceable module is not connected to the base module (20) but in a disconnected or dissembled state. The replaceable module (30) comprises a reservoir (40) holding a liquid (L) to be applied to a body surface of a subject by ejection of the liquid (L) from the device (10) towards the body surface. Furthermore, the replaceable module comprises an ejection unit (50). Although shown in a disconnected state, replaceable module (30) is adapted to be releasably connected to base module (20) (thereby forming a connected state of the device).

In the embodiment as shown in Fig. 1, base module (20) is coupled to a portable electronic device (1) which may, for example be a tablet computer or smartphone and which comprises a screen (2) for the graphical display of information. In the embodiment of Fig. 1, the screen (2) of the portable electronic device (1) is located on the surface of the portable electronic device (1) facing the base module (20) of device (10) in the coupled state of the device, i.e. in the state in which at least the base module (20) of modular device (10) is coupled to the portable electronic device (1). The portable electronic device (1) may be releasably coupled to the (base module (20) of the) device (10) via a coupling unit (90) which may be comprised by the base module (20) of device (10). In the embodiment shown in Fig. 1, coupling unit (90) comprises coupling means (91), for example in the form of a plug connector such as a USB or Lightning® plug connector to be releasably plugged into the corresponding (female) connector of the portable electronic device (1). As also shown in Fig. 1, device (10) furthermore comprises a pumping unit (60) in fluid connection (not shown) with the reservoir (40) and the ejection unit (50) and being adapted to convey the liquid (L) from the reservoir (40) to the ejection unit (50) (in the connected state). As shown in Fig. 1, pumping unit (60) may be comprised by the base module (20) of device (10), however, as shown further below, may also be comprised by replaceable module (30). Device (10) as shown in Fig. 1 furthermore comprises a drive unit (70) for driving the pumping unit (60), a control unit (80) for controlling the ejection of the liquid (L) and a receiving unit (100) for releasably connecting the replaceable module (30) with the base module (20). In the embodiment shown in Fig. 1, the pumping unit (60), the drive unit (70), the control unit (80) and the receiving unit (100) are comprised by the base module (20) of the device (10). It should be noted, however, that especially the pumping unit (60) and/or the drive unit (70) may also be comprised by the replaceable module (30) of the device (10) and that, for example, the receiving unit (100) may be (partially) comprised by both, the base module (20) and the replaceable module (30). In the embodiment shown in Fig. 1, base module (20) of device (10) comprises means for determining the position (21) of the base module (20) or the device (10) relative to the portable electronic device (1), especially in the coupled state. Here, the means for determining the position (21) comprise a stylus that is in contact and interacts with screen (2), preferably a touch-sensitive screen, of portable electronic device (1).

Fig. 2 depicts the present modular administration device (10) in the connected state in which base module (20) is releasably connected to the replaceable module (30) (via receiving unit (100) (not shown) into which replaceable module (30) is inserted. The base module (20), in this Figure as well, comprises coupling unit (90) with coupling means (91) in the form of a plug as well as means for determining the position (21) of the device (10) relative to the portable electronic device (especially in the coupled state). It should be noted, however, that in this Fig. 2 the device (10) is shown in a state in which it is not coupled to a portable electronic device.

In the device (10) as shown in Fig. 2, the base module (20) comprises pumping unit (60), drive unit (70) and control unit (80). Replaceable module (30) comprises reservoir (40) holding the liquid (L) to be applied as a well as ejection unit (50). Ejection unit (50), in this embodiment, is fluidically connected with reservoir (40) via pumping unit (60) and tubing (31) for providing a fluid connection between reservoir (40) and pumping unit (60) as well as from pumping unit (60) to ejection unit (50) through which the liquid (L) may be pumped from reservoir (40) towards ejection unit (50). In this embodiment, accordingly, pumping unit (60) is not comprised by the replaceable module (30) and, accordingly, will not be replaced together with replaceable unit (60) once necessary and, accordingly, can be used repeatedly with a plurality of different replaceable modules (30). It will be understood that in this schematic representation as well, additional functional elements may be present which are necessary for the operation of the device such as electrical, mechanical or fluidic connections or elements which are not shown here.

Fig. 3 shows an alternative embodiment of the present modular application device (10) as well in the connected state in which base module (20) is connected to replaceable module (30). In this embodiment however, pumping unit (60) comprising pump (61) is comprised by the replaceable module such that all components with potential contact to liquid (L), namely reservoir (40), ejection unit (50), tubing (31) as well as pumping unit (60) with pump (61) are comprised by the replaceable module (30) of the present modular application device (10). In this embodiment, drive unit (70) and control unit (80) are still comprised by base module (20). It should be noted, however, that especially drive unit (70) may also be entirely or partly comprised by the replaceable unit (30).

Fig. 4 shows an embodiment of modular device (10) in which the base module (20) and the replaceable module (30) are not connected to each other. In this embodiment, replaceable module (30) comprises the reservoir (40) holding liquid (L) as well as the ejection unit (50) in fluidic connection with the reservoir (40) via pumping unit (60) and tubing (32). Furthermore, replaceable module (30) comprises drive unit (70) with a mechanical energy storage device (71), here in the form of a spring. The situation as depicted in Fig. 4 shows the replaceable module (20) before being connected to the base module (20) with the mechanical energy storage device (71) in a non-tensioned state. It should be noted, however, that the mechanical energy storage device (71) may also be comprised by the replaceable module (30) in a tensioned or, in other words, pre-tensioned state. Fig. 5 shows another embodiment of the device (10) as depicted in Fig. 4, however, with the mechanical energy storage device (71) comprised by base module (20). In both embodiments of Figs. 4 and 5, however, the mechanical energy storage device (71) may be compressed and, accordingly, tensioned, by connection with or, in other words, insertion of the replaceable module (30) in the base module (20). In this tensioned state the mechanical energy storage device (71) may then provide the required (kinetic) energy to drive the pumping unit (60).

Fig. 6 depicts an embodiment of the present modular application device (10) in which the replaceable module (30) is not connected to the base module (20). In this embodiment, replaceable module (30) has the same general setup as in Fig. 3 and to avoid repetitions the common elements are not described here again. In addition to these elements, however, replaceable module (30) comprises a nozzle (51) which is comprised by ejection unit (50) and through which liquid (L) may be ejected. Furthermore, replaceable module (30) comprises a closing cap (32) for closing and protecting the ejection unit (30) (when not in use) to avoid or reduce contamination thereof. Replaceable module (30) also comprises connecting means (101) schematically shown in the form of hooks to interact with corresponding structures in the receiving unit (100) of the base module (20) in the connected state and for generating a releasable but tight connection between the modules. It should be noted, however, that these connecting means (101) may have a broad variety of forms that are suitable for generating a stable but releasable mechanical connection between the base module (20) and the replaceable module (30).

The embodiment of the present application device (10) as depicted in Fig. 6 also comprises a drive unit (70) comprising a mechanical energy storage device (71), here in the exemplary form of a spring comprised by the base unit (20). The drive unit (70) also comprises a priming unit (110) connected to the drive unit mechanical energy storage device (71) and adapted to interact with the replaceable module (30) upon insertion or connecting of the replaceable module (30) into or with the base module (20) to prime or tension the mechanical energy storage device (71).

Fig. 7 depicts an embodiment of the finally assembled system (200) comprising the present modular application device (10) with base module (20) connected to replaceable module (30) and the resulting device (10) in the connected state coupled to portable electronic device (1) with screen (2) via coupling unit (90). Base unit (20) comprises mechanical energy storage device (71) in the exemplary form of a spring which, after insertion of replaceable module (30) into base module (20) and interaction with priming unit (110) is in a compressed or tensioned state. As also shown in the embodiment of Fig. 7, the application device (10) comprises a closing cap (32) for protecting ejection unit (50), for example from contamination or mechanical stress, especially in the unused state when the closing cap (32) is closed. In the opened state as depicted in Fig. 7, closing cap (32) allows for liquid (L) to be ejected from nozzle (50) of injection unit (50) towards a body surface (S) of a subject, in the exemplary embodiment shown in Fig. 7 towards an ocular surface of a subject.

List of references:

1 Portable electronic device

2 Screen

10 Application device

20 Base module

21 Means for determining the position

30 Replaceable module

31 Tubing

32 Closing cap

40 Reservoir

50 Ejection unit

51 Nozzle

60 Pumping unit

61 Pump

70 Drive unit

71 Mechanical energy storage device

80 Control unit

90 Coupling unit

91 Coupling means

100 Receiving unit 101 Connecting means

110 Priming unit

200 System

L Liquid S Body surface

Claims

1. A device (10) for the application of a liquid (L) to a body surface (S) of a subject by ejection of the liquid (L) from the device (10) towards the body surface, wherein the device (10) is adapted to be releasably coupled to a portable electronic device (1) and wherein the device (10) comprises a base module (20) and a replaceable module, wherein the replaceable module (30) is adapted to be releasably connected to the base module (20), the device (10) comprising a reservoir (40) for holding the liquid (L), an ejection unit (50) for the ejection of the liquid (L), a pumping unit (60) in fluid connection with the reservoir (40) and the ejection unit (50) and being adapted to convey the liquid (L) from the reservoir (40) to the ejection unit (50), a drive unit (70) for driving the pumping unit (60), a control unit (80) for controlling the ejection of the liquid (L), a coupling unit (90) for releasably coupling the device (10) to the portable electronic device (1), and a receiving unit (100) for releasably connecting the replaceable module (30) with the base module (20); wherein the replaceable module (30) of the device comprises the reservoir (40) and the ejection unit (50).

2. The device (10) according to claim 1, wherein the body surface (S) of a subject is a surface of an eye of the subject.

3. The device (10) according to claim 1 or 2, wherein the liquid (L) is an aqueous liquid or liquid composition comprising at least one of an excipient and an active pharmaceutical ingredient, for example an ophthalmic active pharmaceutical ingredient.

4. The device (10) according to any one of the preceding claims, wherein the base module (20) of the device comprises the control unit (80), the coupling unit (90) and the receiving unit (100).

5. The device (10) according to any one of the preceding claims, wherein the replaceable module (30) comprises the pumping unit (60).

6. The device (10) according to any one of the preceding claims, wherein the replaceable (30) module comprises the drive unit (70).

7. The device (10) according to any one of the preceding claims, wherein the pumping unit (60) comprises a pump (61) selected from the group consisting of electromechanical pumps, piezo pumps, piston pumps and mechanical pumps.

8. The device (10) according to any one of the preceding claims, wherein the replaceable module (30) comprises all components that are contact with the liquid.

9. The device (10) according to any one of the preceding claims, wherein the drive unit (70) comprises a mechanical energy storage device (71).

10. The device (10) according to claim 9, wherein the replaceable module (30) comprises the energy storage device (71), the reservoir (40), the pumping unit (60), preferably comprising a piston pump (61), and the ejection unit (50).

11. The device (10) according to any one of the preceding claims, wherein the coupling unit (90) comprises coupling means (91) adapted to form a releasable connection, preferably a releasable electro-mechanic connection between the base module (20) and the portable electronic device (1).

12. The device (10) according to any one of the preceding claims, wherein the base module (20) comprises means for determining the position (21) of the base module (20) in relation to the portable electronic device (1) (in the coupled state).

13. A replaceable module (30) adapted to be releasably connected to a base (20) module thereby forming the device (10) according any one of the preceding claims, the replaceable module (30) comprising: a reservoir (40) for holding a liquid (L) to be applied to a body surface (S) of a subject by ejection of the liquid (L) from the device [10] towards the body surface (S), and an ejection unit (50) for the ejection of the liquid (L) (towards the body surface of the subject).

14. The replaceable module (30) according to claim 13, wherein the replaceable module (30) further comprises a pumping unit (60) in fluid connection with the reservoir (40) and the ejection unit (50) and being adapted to convey the liquid (L) from the reservoir (40) to the ejection unit (50).

15. A system (200) for the (contactless) application of a liquid (L) to a body surface (S) of a subject by ejection of the liquid (L) from an application device (10) towards the body surface (S), wherein the system (200) comprises: a) the device (10) according to any one of claims 1 to 12, and b) a portable electronic device (1).