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WO2025087445A1 - Large-aperture ultrafast ultrasound imaging system and method - Google Patents

Large-aperture ultrafast ultrasound imaging system and method Download PDF

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Publication number
WO2025087445A1
WO2025087445A1 PCT/CN2024/133142 CN2024133142W WO2025087445A1 WO 2025087445 A1 WO2025087445 A1 WO 2025087445A1 CN 2024133142 W CN2024133142 W CN 2024133142W WO 2025087445 A1 WO2025087445 A1 WO 2025087445A1
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WIPO (PCT)
Prior art keywords
ultrasonic
aperture
ultrafast
transmitting
ultrasonic transducer
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PCT/CN2024/133142
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French (fr)
Chinese (zh)
Inventor
林励
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Zhejiang Liying Medical Technology Co Ltd
Zhejiang University ZJU
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Zhejiang Liying Medical Technology Co Ltd
Zhejiang University ZJU
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Publication of WO2025087445A1 publication Critical patent/WO2025087445A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08Clinical applications
    • A61B8/0891Clinical applications for diagnosis of blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/488Diagnostic techniques involving Doppler signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data

Definitions

  • the present application belongs to the field of biomedical imaging technology, and in particular, relates to a large-aperture ultrafast ultrasound imaging system and method.
  • Ultrasound imaging is the most widely used examination method in medical imaging technology.
  • the basic principle is that when ultrasound propagates in the human body, due to the difference in acoustic impedance caused by the difference in tissue structure distribution in the human body, the ultrasound is reflected and scattered during the propagation process and is received by the ultrasound array and reconstructed through hardware or software beamforming.
  • Ultrasonic tomography usually uses large-aperture ultrasonic transducer arrays such as circular and polygonal ultrasonic arrays to achieve ultrasonic transmission and reception.
  • Reflective ultrasonic tomography excites individual units on the large-aperture ultrasonic transducer array one by one and receives echo signals for imaging. It has disadvantages such as large data volume and slow imaging speed, which makes it difficult to promote and use in clinical practice.
  • ultrafast ultrasound imaging technology As a new generation of ultrasound technology, ultrafast ultrasound imaging technology has the characteristics of high frame rate and high sensitivity, which breaks through the performance limitations of traditional ultrasound imaging.
  • the main implementation method of ultrafast ultrasound is plane wave imaging technology, which can obtain echo signals in the entire imaging area with one emission. Its pulse repetition frequency is equal to the frame rate, but due to the lack of emission focusing, the imaging signal-to-noise ratio is low and the imaging quality is poor.
  • the purpose of this application is to provide a large-aperture ultrafast ultrasonic imaging system and method to solve the above-mentioned technical problems.
  • a large-aperture ultrafast ultrasonic imaging system comprises an ultrasonic transmitting module and a large-aperture ultrasonic transducer array.
  • the ultrasonic transmitting module is used to generate a transmitting pulse sequence, wherein the transmitting pulse sequence excites the transmitting units on the large-aperture ultrasonic transducer array simultaneously or according to the transmitting delay through pulses of different waveforms to form an ultrasonic pulse wave, and the multiple ultrasonic pulse waves generated by the excitation of multiple transmitting pulse sequences constitute a group of ultrafast ultrasonic sequences;
  • the large-aperture ultrasonic transducer array includes a plurality of ultrasonic transducer units, which are used to receive a transmission pulse sequence generated by an ultrasonic transmission module, and convert the transmission pulse sequence into an ultrasonic pulse wave to transmit to the object to be measured.
  • the ultrasonic pulse wave is reflected and scattered during propagation in the object to be measured, and finally propagates to the large-aperture ultrasonic transducer array, is received by the array, and is converted into an ultrasonic echo signal.
  • the maximum angular difference of the ultrasound propagation direction at any point in the imaging area of different ultrasound transducer units on the large-aperture ultrasound transducer array is greater than 60°.
  • the large-aperture ultrasonic transducer array includes the following forms: one or more arc-shaped ultrasonic transducer arrays form an arc-shaped large-aperture ultrasonic transducer array; multiple linear ultrasonic transducer arrays form a linear large-aperture ultrasonic transducer array; multiple ultrasonic transducer units are arranged in space to form a spherical large-aperture ultrasonic transducer array or a polyhedral large-aperture ultrasonic transducer array.
  • the ultrafast ultrasound sequence includes one or more ultrasound pulse waves, each of which completely covers and excites the imaging area during propagation.
  • the ultrasound pulse wave is any combination of a single excitation angle or a plurality of divergent waves, plane waves, and focused waves with different excitation angles.
  • the excitation angle of the ultrasound pulse wave is changed by changing the emission delay or exciting the emission units at different positions.
  • the variable range of the excitation angle of the focused wave, plane wave, or divergent wave is between -90° and 90°.
  • it also includes a data acquisition module, which is used to receive ultrasonic echo signals, realize analog amplification, analog-to-digital conversion, storage, transmission and output digital signals to the image reconstruction module.
  • a data acquisition module which is used to receive ultrasonic echo signals, realize analog amplification, analog-to-digital conversion, storage, transmission and output digital signals to the image reconstruction module.
  • a system control module is further included, wherein the system control module is used to control The number and distribution of the transmitting units, the properties of the transmitting pulse sequence, the transmitting delay, and the analog amplification gain and sampling rate parameters of the data acquisition module.
  • the system further includes an image reconstruction module, which performs image reconstruction by using a delay-sum based beamforming algorithm.
  • x, z are the coordinates of any point on the sub-image
  • is the ultrasonic pulse wave excitation angle
  • RF is the ultrasonic echo signal
  • is the ultrasonic propagation time
  • i is the index of the ultrasonic transducer unit
  • the ultrafast ultrasound sequence is a coded transmitted ultrasound pulse wave, wherein the coded transmission simultaneously transmits a plurality of ultrasound pulse waves with coded transmission signal amplitudes and excitation angles in a single transmission event, and decodes the signal before image reconstruction.
  • the large-aperture ultrasonic transducer array is composed of one or more curved ultrasonic transducer arrays, and the ultrafast ultrasonic sequence in a single transmission event includes multiple plane waves with different excitation angles and different signal amplitudes.
  • the steps of spatial domain encoding and decoding are as follows:
  • S3 summing the ultrasonic echo signals of different emission events according to the amplitude weight of each emission event to synthesize the echo signal of the ultrasonic pulse wave with a single excitation angle.
  • the present application also discloses an ultrafast ultrasonic imaging method of a large-aperture ultrafast ultrasonic imaging system, comprising the following steps:
  • Step 1 The ultrasonic transmitting module generates a transmitting pulse sequence to excite the large-aperture ultrasonic transducer array.
  • the transmitting pulse sequence excites the transmitting units on the large-aperture ultrasonic transducer array simultaneously or according to the transmitting delay to generate ultrasonic pulse waves.
  • Multiple transmitting pulse sequences excite the generated multiple ultrasonic pulse waves to form a group of ultrafast ultrasonic sequences.
  • Step 2 The large-aperture ultrasonic transducer array receives the transmission pulse sequence generated by the ultrasonic transmission module, and transmits ultrasonic pulse waves to the object to be measured at a large-aperture ultrasonic excitation angle to cover the target imaging range;
  • Step 3 The large-aperture ultrasonic transducer array detects the ultrasonic echo signal from the object to be measured at a large-aperture ultrasonic detection angle and transmits it to the data acquisition module for analog-to-digital conversion, storage, transmission and output of the digital signal to the image reconstruction module for further ultrasonic image reconstruction.
  • the present application adopts multiple ultrasonic transducer units to form a large-aperture ultrasonic transducer array, and simultaneously excites or changes the excitation time of the ultrasonic array units through pulses of different waveforms, obtains multiple frames of plane wave images of the same imaging area from multiple deflected emission angles, and coherently superimposes the multiple frames of images to obtain a composite image. Due to the synthetic focusing effect when superimposing plane wave images corresponding to different deflection angles, this method can effectively improve the signal-to-noise ratio of the imaging results, and different emission angles can improve the edge loss problem of the image.
  • the detection angle is complete and the imaging details are rich.
  • the use of a large-aperture ultrasonic transducer array can cover a larger ultrasonic excitation and ultrasonic reception angle.
  • the existing ultrafast ultrasound technology mostly uses a linear ultrasonic array with limited excitation and detection angles.
  • There are disadvantages such as incomplete imaging result boundaries and low sensitivity to blood flow Doppler signals in the direction parallel to the array.
  • the use of a large-aperture ultrasonic transducer array can make the boundary information of the imaging results more complete and improve the sensitivity to blood flow Doppler signals in different directions.
  • FIG1 is a diagram of a large-aperture ultrafast ultrasonic imaging system of the present application.
  • FIG2 is a diagram of an ultrafast ultrasonic imaging system based on an arc-shaped large-aperture ultrasonic transducer array and a schematic diagram of a focused wave ultrafast ultrasonic sequence of the present application.
  • FIG. 3 is a diagram of an ultrafast ultrasonic imaging system based on a linear large-aperture ultrasonic transducer array to simultaneously excite transmitting units at different positions and a schematic diagram of a plane wave ultrafast ultrasonic sequence according to the present application.
  • FIG. 4 is a diagram of an ultrafast ultrasound imaging system and a schematic diagram of a plane wave ultrafast ultrasound sequence based on simultaneous or delayed excitation of transmitting units at the same position by a linear large-aperture ultrasound transducer array according to the present invention.
  • FIG. 5 is a diagram of an ultrafast ultrasonic imaging system based on an arc-shaped large-aperture ultrasonic transducer array to excite transmitting units at different positions and a schematic diagram of a diverging wave ultrafast ultrasonic sequence according to the present application.
  • FIG. 6 is a diagram of an ultrafast ultrasonic imaging system for adjusting the position of a virtual source based on an arc-shaped large-aperture ultrasonic transducer array and a schematic diagram of a diverging wave ultrafast ultrasonic sequence according to the present application.
  • FIG. 7 is a diagram of an ultrafast ultrasonic imaging system based on a spherical large-aperture ultrasonic transducer array and a schematic diagram of a diverging wave ultrafast ultrasonic imaging sequence according to the present application.
  • FIG8 is a schematic diagram of a diverging wave ultrafast ultrasonic imaging sequence of an ultrafast ultrasonic imaging system atlas based on a polyhedral large-aperture ultrasonic transducer array of the present application.
  • FIG. 9 shows an ultrafast ultrasound sequence in a single emission event, including multiple plane waves with different excitation angles and different signal amplitudes.
  • the large-aperture ultrafast ultrasonic imaging system of the present application mainly includes an ultrasonic transmitting module 1, a large-aperture ultrasonic transducer array 2, a data acquisition module 4, a system control module 3 and an image reconstruction module 5, and secondly also includes a transmitting and receiving conversion switch, a preamplifier circuit and a spatial scanning module.
  • the ultrasonic transmitting module 1 in this embodiment is used to generate a transmitting pulse sequence to excite the large-aperture ultrasonic transducer array 2.
  • the transmitting pulse sequence can excite the transmitting units on the large-aperture ultrasonic transducer array 2 simultaneously or according to the transmission delay through pulses of different waveforms to form an ultrasonic pulse wave.
  • the multiple ultrasonic pulse waves generated by the excitation of multiple transmitting pulse sequences constitute a group of ultrafast ultrasonic sequences.
  • the large-aperture ultrasonic transducer array 2 in this embodiment includes multiple ultrasonic transducer units.
  • the maximum angular difference in the ultrasonic propagation direction of any point in the imaging area of different ultrasonic transducer units on the large-aperture ultrasonic transducer array 2 is greater than 60°. It is used to receive the transmission pulse sequence generated by the ultrasonic transmitting module 1, and convert the transmission pulse sequence into an ultrasonic pulse wave to be transmitted to the object to be measured 6.
  • the ultrasonic pulse wave Due to the difference in acoustic impedance distribution in the object to be measured 6, the ultrasonic pulse wave is reflected and scattered during the propagation process in the object to be measured 6, and finally propagates to the large-aperture ultrasonic transducer array 2, is received by it and converted into an ultrasonic echo signal.
  • the large-aperture ultrasonic transducer array 2 may include one or more arc-shaped ultrasonic transducer arrays, the arc angle of the arc-shaped ultrasonic transducer array ranges from 5° to 359°, and the arc-shaped ultrasonic transducer arrays are combined to form an arc-shaped large-aperture ultrasonic transducer array.
  • the large-aperture ultrasonic transducer array 2 may also include multiple linear ultrasonic transducer arrays, wherein the multiple linear ultrasonic transducer arrays are arranged to form a polygon or a part of a polygon, and the multiple linear ultrasonic transducer arrays are combined to form a linear large-aperture ultrasonic transducer array.
  • the large-aperture ultrasonic transducer array 2 may further include a plurality of ultrasonic transducer units, and the ultrasonic transducer units are spatially arranged to form a part of a sphere, thereby forming a spherical large-aperture ultrasonic transducer array.
  • the large-aperture ultrasonic transducer array 2 may further include a plurality of ultrasonic transducer units, and the ultrasonic transducer units are spatially arranged to form a part of a polyhedron, forming a polyhedron large-aperture ultrasonic transducer array.
  • the data acquisition module 4 in this embodiment receives the ultrasonic echo signal, implements analog amplification, analog-to-digital conversion, storage, transmission, and outputs the digital signal to the image reconstruction module 5 .
  • the system control module 3 in this embodiment controls the number and distribution of the transmitting units, the properties of the transmitting pulse sequence, the transmitting delay, and the analog amplification gain and sampling rate of the data acquisition module 4 and other parameters.
  • the image reconstruction module 5 in this embodiment receives the digital signal output by the data acquisition module 4 and reconstructs the acoustic impedance difference distribution in the body to be measured according to the amplitude, time, phase and frequency information contained therein.
  • the transmit-receive conversion switch in this embodiment is used to realize the switching of the ultrasonic transducer unit between the transmit mode and the receive mode.
  • the preamplifier circuit in this embodiment is used to achieve pre-amplification of the ultrasonic echo signal.
  • the spatial scanning module in this embodiment is used to implement large-aperture ultrasound of the object to be measured.
  • the imaging frame rate of the system is configured to be 100 fps or higher to achieve ultrafast ultrasound imaging.
  • the ultrafast ultrasound sequence includes one or more ultrasound pulse waves, each of which completely covers and excites the imaging area during propagation.
  • the ultrasound pulse wave can be any combination of a single excitation angle or multiple divergent waves, plane waves, and focused waves with different excitation angles.
  • the excitation angle of the focused wave, plane wave, or divergent wave can be variable in the range of -90° to 90°.
  • the large-aperture ultrasonic transducer array 2 is composed of a plurality of arc-shaped ultrasonic transducer arrays, and the ultrafast ultrasonic sequence includes a plurality of focused waves with different excitation angles, and the transmitting units on the selected large-aperture ultrasonic transducer array are excited by the emission pulse sequence simultaneously or according to the emission delay, so that the ultrasonic pulse waves converge in front of the ultrasonic array, thereby making the ultrasonic pulse waves focused waves.
  • the emission pulse sequence changes the excitation angle of the focused wave by exciting the transmitting units at different positions, and sequentially emits wavefront 1, wavefront 2, and wavefront 3.
  • the large-aperture ultrasonic transducer array 2 is composed of a plurality of linear ultrasonic transducer arrays, the ultrafast ultrasonic sequence includes a plurality of plane waves with different excitation angles, and the transmitting pulse sequence changes the excitation angle of the plane wave by simultaneously exciting the transmitting units at different positions, and sequentially transmits wavefront 1, wavefront 2, and wavefront 3.
  • the large-aperture ultrasonic transducer array 2 is composed of a plurality of linear ultrasonic transducer arrays, and the ultrafast ultrasonic sequence includes a plurality of plane waves with different excitation angles.
  • the transmitting pulse sequence excites the transmitting units at the same position simultaneously or with a delay, so that the excitation phases of the transmitting units change linearly with respect to each other, and wavefront 1, wavefront 2, and wavefront 3 are emitted in sequence, thereby adjusting the excitation angle and time of the plane wave.
  • the large-aperture ultrasonic transducer array 2 is composed of a plurality of arc-shaped ultrasonic transducer arrays, and the ultrafast ultrasonic sequence includes a plurality of divergent waves with different excitation angles.
  • virtual sources such as virtual source 1, virtual source 2, and virtual source 3 in FIG5
  • the emission pulse sequence excite the emission unit with a phase delay corresponding to the virtual source
  • the ultrasonic pulse wave can be made into a divergent wave, and by exciting the emission units at different positions, divergent waves with different angles can be emitted in sequence: wavefront 1, wavefront 2, and wavefront 3.
  • the large aperture ultrasonic transducer array 2 is composed of a plurality of arc-shaped ultrasonic transducer arrays, and the ultrafast ultrasonic sequence includes a plurality of divergent waves with different excitation angles.
  • the virtual source such as virtual source 1 and virtual source 3 in FIG6
  • the divergent wave direction can be deflected, thereby achieving divergent wave excitation at different angles.
  • the divergence degree of the divergent wave can be adjusted by moving the virtual source closer to or farther away from the array, and the emission unit can be excited with a phase delay corresponding to the virtual source, so that divergent wave excitation with different divergence degrees can be achieved.
  • the large-aperture ultrasonic transducer array 2 is composed of a plurality of ultrasonic transducer units to form a spherical large-aperture ultrasonic transducer array.
  • the ultrafast ultrasonic sequence includes a plurality of divergent waves with different excitation angles, such as wavefront 1, wavefront 2, and wavefront 3 in FIG7 .
  • tx1 and tx2 in the figure represent the distribution range of the transmitting units.
  • the large-aperture ultrasonic transducer array 2 is composed of a plurality of ultrasonic transducer units to form a polyhedral large-aperture ultrasonic transducer array.
  • the ultrafast ultrasonic sequence includes a plurality of divergent waves with different excitation angles, such as wavefront 1 and wavefront 2 in FIG8 .
  • tx1 and tx2 in the figure represent the distribution range of the transmitting units.
  • the image reconstruction module 5 in this embodiment can perform image reconstruction by a delayed-sum based beamforming algorithm.
  • x, z are the coordinates of any point on the sub-image
  • is the ultrasonic pulse wave excitation angle
  • RF is the ultrasonic echo signal
  • is the ultrasonic propagation time
  • the sub-images obtained by different ultrasonic pulse wave excitations are coherently superimposed to obtain the final reconstructed image.
  • i is the index of the ultrasonic transducer unit, that is, the i-th ultrasonic transducer unit.
  • the value range of i is from 1 to N, where N is the number of ultrasonic transducer units.
  • the ultrafast ultrasound sequence in this embodiment may also be a coded transmitted ultrasound pulse wave, wherein the coded transmission simultaneously transmits multiple ultrasound pulse waves with encoded transmission signal amplitudes and excitation angles in a single transmission event, and decodes the signal before image reconstruction to improve the image signal-to-noise ratio.
  • the large-aperture ultrasonic transducer array 2 is composed of one or more arc-shaped ultrasonic transducer arrays.
  • the ultrafast ultrasonic sequence in a single emission event includes multiple plane waves with different excitation angles and different signal amplitudes.
  • the steps of spatial domain encoding and decoding are as follows:
  • S3 summing the ultrasonic echo signals of different emission events according to the amplitude weight of each emission event to synthesize the echo signal of the ultrasonic pulse wave with a single excitation angle.
  • a large-aperture ultrafast ultrasonic imaging method of the present application comprises the following steps:
  • Step 1 The ultrasonic transmitting module 1 generates a transmitting pulse sequence to excite the large-aperture ultrasonic transducer array 2.
  • the transmitting pulse sequence excites the transmitting units on the large-aperture ultrasonic transducer array simultaneously or according to the transmitting delay to generate an ultrasonic pulse wave.
  • Multiple ultrasonic pulse waves generated by the excitation of multiple transmitting pulse sequences constitute a group of ultrafast ultrasonic sequences.
  • Step 2 The large-aperture ultrasonic transducer array 2 receives the transmission pulse sequence generated by the ultrasonic transmission module, and transmits ultrasonic pulse waves to the object to be measured 6 at a larger ultrasonic excitation angle to cover the target imaging range.
  • Step 3 The large-aperture ultrasonic transducer array 2 detects the ultrasonic echo signal from the object to be tested at a larger ultrasonic detection angle and transmits it to the data acquisition module 4, performs analog-to-digital conversion, stores, transmits and outputs the digital signal to the image reconstruction module 5 for further ultrasonic image reconstruction.

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Abstract

A large-aperture ultrafast ultrasound imaging system and method. The large-aperture ultrafast ultrasound imaging system comprises an ultrasound transmitting module (1) and a large-aperture ultrasound transducer array (2). The ultrasound transmitting module (1) is used for generating a transmitting pulse sequence, wherein the transmitting pulse sequence excites, by means of pulses of different waveforms, a transmitting unit on the large-aperture ultrasound transducer array (2) at the same time or according to a transmission delay, so as to form an ultrasound pulse wave, and a plurality of ultrasound pulse waves generated by means of the excitation of a plurality of transmitting pulse sequences form a group of ultrafast ultrasound sequences. The large-aperture ultrasound transducer array (2) comprises a plurality of ultrasound transducer units, wherein each ultrasound transducer unit is used for receiving the transmitting pulse sequence generated by means of the ultrasound transmitting module, converting the transmitting pulse sequence into the ultrasound pulse wave and transmitting same to an object under test. Therefore, the imaging rate is greatly improved, the detection angle is complete, imaging details are rich, boundary information is more complete, and the sensitivity to blood flow Doppler signals in different directions is also improved.

Description

一种大孔径超快超声成像系统及方法Large aperture ultrafast ultrasonic imaging system and method

本申请要求于2023年10月25日提交中国专利局、申请号为202311388008.5、发明名称为“一种大孔径超快超声成像系统及方法”的中国专利申请的优先权,其全部内容通过引用结合在本申请中。This application claims the priority of the Chinese patent application filed with the China Patent Office on October 25, 2023, with application number 202311388008.5 and invention name “A large-aperture ultrafast ultrasonic imaging system and method”, the entire contents of which are incorporated by reference in this application.

技术领域Technical Field

本申请属于生物医学影像技术领域,尤其涉及一种大孔径超快超声成像系统及方法。The present application belongs to the field of biomedical imaging technology, and in particular, relates to a large-aperture ultrafast ultrasound imaging system and method.

背景技术Background Art

超声成像作为医学影像技术中最为广泛使用的检查手段,基本原理是超声在人体中传播时,由于人体中的组织结构分布差异导致的声阻抗差异,超声在传播过程中发生反射、散射并被超声阵列接收并通过硬件或软件波束形成重建图像。Ultrasound imaging is the most widely used examination method in medical imaging technology. The basic principle is that when ultrasound propagates in the human body, due to the difference in acoustic impedance caused by the difference in tissue structure distribution in the human body, the ultrasound is reflected and scattered during the propagation process and is received by the ultrasound array and reconstructed through hardware or software beamforming.

超声层析成像通常采用圆形、多边形超声阵列等大孔径超声换能器阵列实现超声发射和接收,反射式超声层析成像通过逐一激发大孔径超声换能器阵列上的单个单元并接收回波信号进行成像,存在数据量大、成像速度慢等缺点,导致难以在临床中推广使用。Ultrasonic tomography usually uses large-aperture ultrasonic transducer arrays such as circular and polygonal ultrasonic arrays to achieve ultrasonic transmission and reception. Reflective ultrasonic tomography excites individual units on the large-aperture ultrasonic transducer array one by one and receives echo signals for imaging. It has disadvantages such as large data volume and slow imaging speed, which makes it difficult to promote and use in clinical practice.

超快超声成像技术作为新一代超声技术,其所具备的高帧频和高灵敏度的特点突破了传统超声成像的性能局限。超快超声的主要实现方式是平面波成像技术,采用一次发射即可得到整个成像区域内的回波信号,其脉冲重复频率等于帧频,但由于缺少发射聚焦,成像信噪比低,成像质量差。As a new generation of ultrasound technology, ultrafast ultrasound imaging technology has the characteristics of high frame rate and high sensitivity, which breaks through the performance limitations of traditional ultrasound imaging. The main implementation method of ultrafast ultrasound is plane wave imaging technology, which can obtain echo signals in the entire imaging area with one emission. Its pulse repetition frequency is equal to the frame rate, but due to the lack of emission focusing, the imaging signal-to-noise ratio is low and the imaging quality is poor.

现有的超快超声成像技术多使用一个线性阵列,由于一个线性阵列的发射方向性限制,平面波的倾斜角度不宜过大,进一步限制了其对垂直阵列方向的器官组织边界及平行阵列方向的多普勒信号的探测灵敏度。同时由于线性阵列的接收孔径有限,仅能接收到部分超声反射、散射回波信号,限制了成像分辨率、对比度等。Existing ultrafast ultrasound imaging technologies mostly use a linear array. Due to the emission directionality limitation of a linear array, the tilt angle of the plane wave should not be too large, which further limits its detection sensitivity to the organ tissue boundary perpendicular to the array direction and the Doppler signal parallel to the array direction. At the same time, due to the limited receiving aperture of the linear array, only part of the ultrasound reflection and scattered echo signals can be received, which limits the imaging resolution and contrast.

发明内容Summary of the invention

本申请目的在于提供一种大孔径超快超声成像系统及方法,以解决上述的技术问题。The purpose of this application is to provide a large-aperture ultrafast ultrasonic imaging system and method to solve the above-mentioned technical problems.

为解决上述技术问题,本申请的大孔径超快超声成像系统及方法的具 体技术方案如下:In order to solve the above technical problems, the large aperture ultrafast ultrasonic imaging system and method of the present application are specifically The technical solution is as follows:

一种大孔径超快超声成像系统,包括超声发射模块和大孔径超声换能器阵列,A large-aperture ultrafast ultrasonic imaging system comprises an ultrasonic transmitting module and a large-aperture ultrasonic transducer array.

所述超声发射模块用于生成发射脉冲序列,所述发射脉冲序列通过不同波形的脉冲同时或按发射延时激发大孔径超声换能器阵列上的发射单元,形成超声脉冲波,多个发射脉冲序列激发生成的多个超声脉冲波组成一组超快超声序列;The ultrasonic transmitting module is used to generate a transmitting pulse sequence, wherein the transmitting pulse sequence excites the transmitting units on the large-aperture ultrasonic transducer array simultaneously or according to the transmitting delay through pulses of different waveforms to form an ultrasonic pulse wave, and the multiple ultrasonic pulse waves generated by the excitation of multiple transmitting pulse sequences constitute a group of ultrafast ultrasonic sequences;

所述大孔径超声换能器阵列包括多个超声换能器单元,所述超声换能器单元用于接收超声发射模块生成的发射脉冲序列,并将发射脉冲序列转换为超声脉冲波向待测体发射,所述超声脉冲波在待测体内传播过程中发生反射、散射,最终传播至大孔径超声换能器阵列被其接收并转换为超声回波信号。The large-aperture ultrasonic transducer array includes a plurality of ultrasonic transducer units, which are used to receive a transmission pulse sequence generated by an ultrasonic transmission module, and convert the transmission pulse sequence into an ultrasonic pulse wave to transmit to the object to be measured. The ultrasonic pulse wave is reflected and scattered during propagation in the object to be measured, and finally propagates to the large-aperture ultrasonic transducer array, is received by the array, and is converted into an ultrasonic echo signal.

在一实施方式中,所述大孔径超声换能器阵列上不同超声换能器单元的成像区域内任意一点超声传播方向的最大角度差异在60°以上。In one embodiment, the maximum angular difference of the ultrasound propagation direction at any point in the imaging area of different ultrasound transducer units on the large-aperture ultrasound transducer array is greater than 60°.

在一实施方式中,所述大孔径超声换能器阵列包括以下几种形式:一个或多个弧形超声换能器阵列组成弧形大孔径超声换能器阵列;多个线性超声换能器阵列组成线性大孔径超声换能器阵列;多个超声换能器单元在空间中排布形成球面大孔径超声换能器阵列或多面体大孔径超声换能器阵列。In one embodiment, the large-aperture ultrasonic transducer array includes the following forms: one or more arc-shaped ultrasonic transducer arrays form an arc-shaped large-aperture ultrasonic transducer array; multiple linear ultrasonic transducer arrays form a linear large-aperture ultrasonic transducer array; multiple ultrasonic transducer units are arranged in space to form a spherical large-aperture ultrasonic transducer array or a polyhedral large-aperture ultrasonic transducer array.

在一实施方式中,所述超快超声序列包括一个或多个超声脉冲波,每个超声脉冲波在传播过程中完全覆盖并激发成像区域,在发射脉冲序列控制下,所述超声脉冲波为单一激发角度或多个不同激发角度的发散波、平面波、聚焦波的任意组合,通过改变发射延时或激发不同位置处的发射单元改变超声脉冲波的激发角度,所述聚焦波、平面波或发散波激发角度可变范围在-90°到90°之间。In one embodiment, the ultrafast ultrasound sequence includes one or more ultrasound pulse waves, each of which completely covers and excites the imaging area during propagation. Under the control of the emission pulse sequence, the ultrasound pulse wave is any combination of a single excitation angle or a plurality of divergent waves, plane waves, and focused waves with different excitation angles. The excitation angle of the ultrasound pulse wave is changed by changing the emission delay or exciting the emission units at different positions. The variable range of the excitation angle of the focused wave, plane wave, or divergent wave is between -90° and 90°.

在一实施方式中,还包括数据采集模块,所述数据采集模块用于接收超声回波信号,实现模拟放大、模数转换、存储、传输并输出数字信号至图像重建模块。In one embodiment, it also includes a data acquisition module, which is used to receive ultrasonic echo signals, realize analog amplification, analog-to-digital conversion, storage, transmission and output digital signals to the image reconstruction module.

在一实施方式中,还包括系统控制模块,所述系统控制模块用于控制 所述发射单元的数量、分布和所述发射脉冲序列性质、发射延时和所述数据采集模块的模拟放大增益、采样率参数。In one embodiment, a system control module is further included, wherein the system control module is used to control The number and distribution of the transmitting units, the properties of the transmitting pulse sequence, the transmitting delay, and the analog amplification gain and sampling rate parameters of the data acquisition module.

在一实施方式中,还包括图像重建模块,所述图像重建模块通过基于延迟求和的波束形成算法进行图像重建。In one embodiment, the system further includes an image reconstruction module, which performs image reconstruction by using a delay-sum based beamforming algorithm.

在一实施方式中,所述图像重建模块通过超快超声序列中单个超声脉冲波沿某个角度激发得到的回波信号重建形成子图像,子图像上任意一点的灰度值为:
I(x,z)=∑iRF(i,τ(i,α,x,z),α);
In one embodiment, the image reconstruction module reconstructs the echo signal obtained by exciting a single ultrasonic pulse wave at a certain angle in the ultrafast ultrasonic sequence to form a sub-image, and the gray value of any point on the sub-image is:
I(x,z)=∑ i RF(i,τ(i,α,x,z),α);

其中,x,z为子图像上任意一点的坐标,α为超声脉冲波激发角度,RF为超声回波信号,τ为超声传播时间,不同超声脉冲波激发得到的子图像相干叠加,得到最终重建图像;i为超声换能器单元的索引;Where x, z are the coordinates of any point on the sub-image, α is the ultrasonic pulse wave excitation angle, RF is the ultrasonic echo signal, τ is the ultrasonic propagation time, and the sub-images obtained by different ultrasonic pulse wave excitations are coherently superimposed to obtain the final reconstructed image; i is the index of the ultrasonic transducer unit;

所述超快超声序列为编码发射的超声脉冲波,所述编码发射在单次发射事件中同时发射多个发射信号幅度和激发角度经过编码的超声脉冲波,并在图像重建前对信号进行解码。The ultrafast ultrasound sequence is a coded transmitted ultrasound pulse wave, wherein the coded transmission simultaneously transmits a plurality of ultrasound pulse waves with coded transmission signal amplitudes and excitation angles in a single transmission event, and decodes the signal before image reconstruction.

在一实施方式中,所述大孔径超声换能器阵列由一个或多个弧形超声换能器阵列组成,单次发射事件中超快超声序列包括多个不同激发角度、不同信号幅度的平面波,空间域编码及解码的步骤如下:In one embodiment, the large-aperture ultrasonic transducer array is composed of one or more curved ultrasonic transducer arrays, and the ultrafast ultrasonic sequence in a single transmission event includes multiple plane waves with different excitation angles and different signal amplitudes. The steps of spatial domain encoding and decoding are as follows:

S1:构造哈达玛矩阵;S1: construct Hadamard matrix;

S2:每次发射事件中,根据哈达玛矩阵每行或每列的元素,以对应幅度权重的发射序列同时激发多个不同区域的发射单元;S2: In each emission event, according to the elements of each row or column of the Hadamard matrix, the emission units in multiple different regions are excited simultaneously with the emission sequence corresponding to the amplitude weight;

S3:根据每次发射事件的幅度权重对不同发射事件的超声回波信号求和,合成单个激发角度超声脉冲波的回波信号。S3: summing the ultrasonic echo signals of different emission events according to the amplitude weight of each emission event to synthesize the echo signal of the ultrasonic pulse wave with a single excitation angle.

本申请还公开了一种大孔径超快超声成像系统的超快超声成像方法,包括如下步骤:The present application also discloses an ultrafast ultrasonic imaging method of a large-aperture ultrafast ultrasonic imaging system, comprising the following steps:

步骤1:超声发射模块生成发射脉冲序列激发大孔径超声换能器阵列,发射脉冲序列同时或按发射延时激发大孔径超声换能器阵列上的发射单元,生成超声脉冲波,多个发射脉冲序列激发生成的多个超声脉冲波,组成一组超快超声序列; Step 1: The ultrasonic transmitting module generates a transmitting pulse sequence to excite the large-aperture ultrasonic transducer array. The transmitting pulse sequence excites the transmitting units on the large-aperture ultrasonic transducer array simultaneously or according to the transmitting delay to generate ultrasonic pulse waves. Multiple transmitting pulse sequences excite the generated multiple ultrasonic pulse waves to form a group of ultrafast ultrasonic sequences.

步骤2:大孔径超声换能器阵列接收超声发射模块生成的发射脉冲序列,以大孔径的超声激发角度向待测体发射超声脉冲波,覆盖目标成像范围;Step 2: The large-aperture ultrasonic transducer array receives the transmission pulse sequence generated by the ultrasonic transmission module, and transmits ultrasonic pulse waves to the object to be measured at a large-aperture ultrasonic excitation angle to cover the target imaging range;

步骤3:大孔径超声换能器阵列以大孔径的超声探测角度探测来自待测体的超声回波信号并传输至数据采集模块,进行模数转换、存储、传输并输出数字信号至图像重建模块进一步进行超声图像重建。Step 3: The large-aperture ultrasonic transducer array detects the ultrasonic echo signal from the object to be measured at a large-aperture ultrasonic detection angle and transmits it to the data acquisition module for analog-to-digital conversion, storage, transmission and output of the digital signal to the image reconstruction module for further ultrasonic image reconstruction.

本申请的大孔径超快超声成像系统及方法具有以下优点:The large-aperture ultrafast ultrasonic imaging system and method of the present application have the following advantages:

本申请采用多个超声换能器单元形成大孔径超声换能器阵列,通过不同波形的脉冲同时激发或改变超声阵列单元的激发时间,从多个偏转的发射角度中获得同一成像区域的多帧平面波图像,并将多帧图像相干叠加得到复合图像,由于不同偏转角对应平面波图像叠加时的合成聚焦作用,该方法能够有效提高成像结果的信噪比,同时不同发射角度可改善图像的边缘缺失问题。The present application adopts multiple ultrasonic transducer units to form a large-aperture ultrasonic transducer array, and simultaneously excites or changes the excitation time of the ultrasonic array units through pulses of different waveforms, obtains multiple frames of plane wave images of the same imaging area from multiple deflected emission angles, and coherently superimposes the multiple frames of images to obtain a composite image. Due to the synthetic focusing effect when superimposing plane wave images corresponding to different deflection angles, this method can effectively improve the signal-to-noise ratio of the imaging results, and different emission angles can improve the edge loss problem of the image.

(1)成像速度快,相比反射式超声层析成像逐一激发超声换能器单元的成像方式,大孔径超快超声成像采用同时激发发射型超声换能器单元的方式,一次发射产生的超声脉冲波可辐射整个有效成像区域,采集到整个有效成像区域内的超声信号,使成像速率得到较大提升。(1) Fast imaging speed. Compared with the imaging method of reflection ultrasonic tomography that excites ultrasonic transducer units one by one, large-aperture ultrafast ultrasonic imaging adopts the method of simultaneously exciting emission-type ultrasonic transducer units. The ultrasonic pulse wave generated by one emission can radiate the entire effective imaging area and collect ultrasonic signals in the entire effective imaging area, which greatly improves the imaging speed.

(2)探测角度完整,成像细节丰富,采用大孔径超声换能器阵列,能够覆盖更大的超声激发和超声接收角度,而现有超快超声技术多采用一个线性超声阵列,激发和探测角度有限,存在成像结果边界不完整、对平行阵列方向的血流多普勒信号灵敏度低等缺点,采用大孔径超声换能器阵列可使成像结果的边界信息更加完整,同时提高对不同方向血流多普勒信号的灵敏度。(2) The detection angle is complete and the imaging details are rich. The use of a large-aperture ultrasonic transducer array can cover a larger ultrasonic excitation and ultrasonic reception angle. The existing ultrafast ultrasound technology mostly uses a linear ultrasonic array with limited excitation and detection angles. There are disadvantages such as incomplete imaging result boundaries and low sensitivity to blood flow Doppler signals in the direction parallel to the array. The use of a large-aperture ultrasonic transducer array can make the boundary information of the imaging results more complete and improve the sensitivity to blood flow Doppler signals in different directions.

说明书附图Instruction Manual

图1为本申请大孔径超快超声成像系统图。FIG1 is a diagram of a large-aperture ultrafast ultrasonic imaging system of the present application.

图2为本申请基于弧形大孔径超声换能器阵列的超快超声成像系统图及聚焦波超快超声序列示意图。FIG2 is a diagram of an ultrafast ultrasonic imaging system based on an arc-shaped large-aperture ultrasonic transducer array and a schematic diagram of a focused wave ultrafast ultrasonic sequence of the present application.

图3为本申请基于线性大孔径超声换能器阵列同时激发不同位置处的发射单元的超快超声成像系统图及平面波超快超声序列示意图。 3 is a diagram of an ultrafast ultrasonic imaging system based on a linear large-aperture ultrasonic transducer array to simultaneously excite transmitting units at different positions and a schematic diagram of a plane wave ultrafast ultrasonic sequence according to the present application.

图4为本申请基于线性大孔径超声换能器阵列同时或延时激发相同位置处的发射单元的超快超声成像系统图及平面波超快超声序列示意图。4 is a diagram of an ultrafast ultrasound imaging system and a schematic diagram of a plane wave ultrafast ultrasound sequence based on simultaneous or delayed excitation of transmitting units at the same position by a linear large-aperture ultrasound transducer array according to the present invention.

图5为本申请基于弧形大孔径超声换能器阵列激发不同位置处的发射单元的超快超声成像系统图及发散波超快超声序列示意图。5 is a diagram of an ultrafast ultrasonic imaging system based on an arc-shaped large-aperture ultrasonic transducer array to excite transmitting units at different positions and a schematic diagram of a diverging wave ultrafast ultrasonic sequence according to the present application.

图6为本申请基于弧形大孔径超声换能器阵列调节虚拟源位置的超快超声成像系统图及发散波超快超声序列示意图。6 is a diagram of an ultrafast ultrasonic imaging system for adjusting the position of a virtual source based on an arc-shaped large-aperture ultrasonic transducer array and a schematic diagram of a diverging wave ultrafast ultrasonic sequence according to the present application.

图7为本申请基于球面大孔径超声换能器阵列的超快超声成像系统图及发散波超快超声成像序列示意图。FIG. 7 is a diagram of an ultrafast ultrasonic imaging system based on a spherical large-aperture ultrasonic transducer array and a schematic diagram of a diverging wave ultrafast ultrasonic imaging sequence according to the present application.

图8为本申请基于多面体大孔径超声换能器阵列的超快超声成像系统图集发散波超快超声成像序列示意图。FIG8 is a schematic diagram of a diverging wave ultrafast ultrasonic imaging sequence of an ultrafast ultrasonic imaging system atlas based on a polyhedral large-aperture ultrasonic transducer array of the present application.

图9为单次发射事件中超快超声序列包括多个不同激发角度、不同信号幅度的平面波。FIG. 9 shows an ultrafast ultrasound sequence in a single emission event, including multiple plane waves with different excitation angles and different signal amplitudes.

附图标记:1、超声发射模块;2、大孔径超声换能器阵列;3、系统控制模块;4、数据采集模块;5、图像重建模块、6、待测体。Figure numerals: 1. Ultrasonic transmitting module; 2. Large-aperture ultrasonic transducer array; 3. System control module; 4. Data acquisition module; 5. Image reconstruction module; 6. Object to be measured.

具体实施方式DETAILED DESCRIPTION

为了更好地了解本申请的目的、结构及功能,下面结合附图,对本申请一种大孔径超快超声成像系统及方法做进一步详细的描述。In order to better understand the purpose, structure and function of the present application, the following is a further detailed description of a large-aperture ultrafast ultrasonic imaging system and method of the present application in conjunction with the accompanying drawings.

如图1所示,本申请的大孔径超快超声成像系统,主要包括超声发射模块1、大孔径超声换能器阵列2、数据采集模块4、系统控制模块3和图像重建模块5,其次还包括发射接收转换开关、前置放大电路和空间扫描模块。As shown in Figure 1, the large-aperture ultrafast ultrasonic imaging system of the present application mainly includes an ultrasonic transmitting module 1, a large-aperture ultrasonic transducer array 2, a data acquisition module 4, a system control module 3 and an image reconstruction module 5, and secondly also includes a transmitting and receiving conversion switch, a preamplifier circuit and a spatial scanning module.

本实施方式中的超声发射模块1,用于生成发射脉冲序列激发大孔径超声换能器阵列2,所述发射脉冲序列可通过不同波形的脉冲同时或按发射延时激发大孔径超声换能器阵列2上的发射单元,形成超声脉冲波,多个发射脉冲序列激发生成的多个超声脉冲波组成一组超快超声序列。 The ultrasonic transmitting module 1 in this embodiment is used to generate a transmitting pulse sequence to excite the large-aperture ultrasonic transducer array 2. The transmitting pulse sequence can excite the transmitting units on the large-aperture ultrasonic transducer array 2 simultaneously or according to the transmission delay through pulses of different waveforms to form an ultrasonic pulse wave. The multiple ultrasonic pulse waves generated by the excitation of multiple transmitting pulse sequences constitute a group of ultrafast ultrasonic sequences.

本实施方式中的大孔径超声换能器阵列2,包括多个超声换能器单元,大孔径超声换能器阵列2上不同超声换能器单元的成像区域内任意一点超声传播方向的最大角度差异在60°以上,用于接收超声发射模块1生成的发射脉冲序列,并将发射脉冲序列转换为超声脉冲波向待测体6发射,超声脉冲波由于待测体6内声阻抗分布差异,在待测体6内传播过程中发生反射、散射,最终传播至大孔径超声换能器阵列2被其接收并转换为超声回波信号。The large-aperture ultrasonic transducer array 2 in this embodiment includes multiple ultrasonic transducer units. The maximum angular difference in the ultrasonic propagation direction of any point in the imaging area of different ultrasonic transducer units on the large-aperture ultrasonic transducer array 2 is greater than 60°. It is used to receive the transmission pulse sequence generated by the ultrasonic transmitting module 1, and convert the transmission pulse sequence into an ultrasonic pulse wave to be transmitted to the object to be measured 6. Due to the difference in acoustic impedance distribution in the object to be measured 6, the ultrasonic pulse wave is reflected and scattered during the propagation process in the object to be measured 6, and finally propagates to the large-aperture ultrasonic transducer array 2, is received by it and converted into an ultrasonic echo signal.

如图2所示,所述大孔径超声换能器阵列2可包括一个或多个弧形超声换能器阵列,所述弧形超声换能器阵列的弧度范围在5°至359°,弧形超声换能器阵列组合形成弧形大孔径超声换能器阵列。As shown in FIG. 2 , the large-aperture ultrasonic transducer array 2 may include one or more arc-shaped ultrasonic transducer arrays, the arc angle of the arc-shaped ultrasonic transducer array ranges from 5° to 359°, and the arc-shaped ultrasonic transducer arrays are combined to form an arc-shaped large-aperture ultrasonic transducer array.

如图3-图4所示,所述大孔径超声换能器阵列2还可包括多个线性超声换能器阵列,多个所述线性超声换能器阵列排列形成一个多边形或多边形的一部分,多个线性超声换能器阵列组合形成线性大孔径超声换能器阵列。As shown in FIG. 3-4, the large-aperture ultrasonic transducer array 2 may also include multiple linear ultrasonic transducer arrays, wherein the multiple linear ultrasonic transducer arrays are arranged to form a polygon or a part of a polygon, and the multiple linear ultrasonic transducer arrays are combined to form a linear large-aperture ultrasonic transducer array.

如图7所示,所述大孔径超声换能器阵列2还可包括多个超声换能器单元,所述超声换能器单元在空间排布成球面的一部分,形成球面大孔径超声换能器阵列。As shown in FIG. 7 , the large-aperture ultrasonic transducer array 2 may further include a plurality of ultrasonic transducer units, and the ultrasonic transducer units are spatially arranged to form a part of a sphere, thereby forming a spherical large-aperture ultrasonic transducer array.

如图8所示,所述大孔径超声换能器阵列2还可包括多个超声换能器单元,所述超声换能器单元在空间排布成多面体的一部分,形成多面体大孔径超声换能器阵列。As shown in FIG. 8 , the large-aperture ultrasonic transducer array 2 may further include a plurality of ultrasonic transducer units, and the ultrasonic transducer units are spatially arranged to form a part of a polyhedron, forming a polyhedron large-aperture ultrasonic transducer array.

本实施方式中的数据采集模块4,接收超声回波信号,实现模拟放大、模数转换、存储、传输并输出数字信号至图像重建模块5。 The data acquisition module 4 in this embodiment receives the ultrasonic echo signal, implements analog amplification, analog-to-digital conversion, storage, transmission, and outputs the digital signal to the image reconstruction module 5 .

本实施方式中的系统控制模块3,控制所述发射单元的数量、分布和所述发射脉冲序列性质、发射延时和所述数据采集模块4的模拟放大增益、采样率等参数。The system control module 3 in this embodiment controls the number and distribution of the transmitting units, the properties of the transmitting pulse sequence, the transmitting delay, and the analog amplification gain and sampling rate of the data acquisition module 4 and other parameters.

本实施方式中的图像重建模块5,接收数据采集模块4输出的数字信号并根据所包含的幅度、时间、相位和频率信息重建待测体内的声阻抗差异分布。The image reconstruction module 5 in this embodiment receives the digital signal output by the data acquisition module 4 and reconstructs the acoustic impedance difference distribution in the body to be measured according to the amplitude, time, phase and frequency information contained therein.

本实施方式中的发射接收转换开关用以实现超声换能器单元在发射和接收模式下的切换。The transmit-receive conversion switch in this embodiment is used to realize the switching of the ultrasonic transducer unit between the transmit mode and the receive mode.

本实施方式中的前置放大电路用于实现超声回波信号的预放大。The preamplifier circuit in this embodiment is used to achieve pre-amplification of the ultrasonic echo signal.

本实施方式中的空间扫描模块用于实现对待测物和大孔径超声。The spatial scanning module in this embodiment is used to implement large-aperture ultrasound of the object to be measured.

所述系统的成像帧率配置为100fps或更高帧率,以实现超快超声成像。The imaging frame rate of the system is configured to be 100 fps or higher to achieve ultrafast ultrasound imaging.

超快超声序列包括一个或多个超声脉冲波,每个超声脉冲波在传播过程中完全覆盖并激发成像区域。在发射脉冲序列控制下,超声脉冲波可为单一激发角度或多个不同激发角度的发散波、平面波、聚焦波的任意组合。聚焦波、平面波或发散波激发角度可变范围在-90°到90°之间。The ultrafast ultrasound sequence includes one or more ultrasound pulse waves, each of which completely covers and excites the imaging area during propagation. Under the control of the transmission pulse sequence, the ultrasound pulse wave can be any combination of a single excitation angle or multiple divergent waves, plane waves, and focused waves with different excitation angles. The excitation angle of the focused wave, plane wave, or divergent wave can be variable in the range of -90° to 90°.

如图2所示,大孔径超声换能器阵列2由多个弧形超声换能器阵列组成,超快超声序列包括多个不同激发角度的聚焦波,通过发射脉冲序列同时或按发射延时激发所选大孔径超声换能器阵列上的发射单元,使所述超声脉冲波汇聚于超声阵列前,从而使超声脉冲波为聚焦波。发射脉冲序列通过激发不同位置处的发射单元,改变聚焦波的激发角度,依次发射波前1、波前2、波前3。 As shown in FIG2 , the large-aperture ultrasonic transducer array 2 is composed of a plurality of arc-shaped ultrasonic transducer arrays, and the ultrafast ultrasonic sequence includes a plurality of focused waves with different excitation angles, and the transmitting units on the selected large-aperture ultrasonic transducer array are excited by the emission pulse sequence simultaneously or according to the emission delay, so that the ultrasonic pulse waves converge in front of the ultrasonic array, thereby making the ultrasonic pulse waves focused waves. The emission pulse sequence changes the excitation angle of the focused wave by exciting the transmitting units at different positions, and sequentially emits wavefront 1, wavefront 2, and wavefront 3.

如图3所示,大孔径超声换能器阵列2由多个线性超声换能器阵列组成,超快超声序列包括多个不同激发角度的平面波,发射脉冲序列通过同时激发不同位置处的发射单元,改变平面波的激发角度,依次发射波前1、波前2、波前3。As shown in FIG3 , the large-aperture ultrasonic transducer array 2 is composed of a plurality of linear ultrasonic transducer arrays, the ultrafast ultrasonic sequence includes a plurality of plane waves with different excitation angles, and the transmitting pulse sequence changes the excitation angle of the plane wave by simultaneously exciting the transmitting units at different positions, and sequentially transmits wavefront 1, wavefront 2, and wavefront 3.

如图4所示,大孔径超声换能器阵列2由多个线性超声换能器阵列组成,超快超声序列包括多个不同激发角度的平面波,发射脉冲序列通过同时或延时激发相同位置处的发射单元,使发射单元彼此激发相位呈现线性变化,依次发射波前1、波前2、波前3,实现调整平面波的激发角度和时间。As shown in FIG4 , the large-aperture ultrasonic transducer array 2 is composed of a plurality of linear ultrasonic transducer arrays, and the ultrafast ultrasonic sequence includes a plurality of plane waves with different excitation angles. The transmitting pulse sequence excites the transmitting units at the same position simultaneously or with a delay, so that the excitation phases of the transmitting units change linearly with respect to each other, and wavefront 1, wavefront 2, and wavefront 3 are emitted in sequence, thereby adjusting the excitation angle and time of the plane wave.

如图5所示,大孔径超声换能器阵列2由多个弧形超声换能器阵列组成,超快超声序列包括多个不同激发角度的发散波,通过定义虚拟源,如图5中虚拟源1、虚拟源2、虚拟源3,并使发射脉冲序列以与虚拟源相对应的相位延迟激发发射单元,可使超声脉冲波为发散波,通过激发不同位置处的发射单元可依次发射不同角度的发散波:波前1、波前2、波前3。As shown in FIG5 , the large-aperture ultrasonic transducer array 2 is composed of a plurality of arc-shaped ultrasonic transducer arrays, and the ultrafast ultrasonic sequence includes a plurality of divergent waves with different excitation angles. By defining virtual sources, such as virtual source 1, virtual source 2, and virtual source 3 in FIG5 , and making the emission pulse sequence excite the emission unit with a phase delay corresponding to the virtual source, the ultrasonic pulse wave can be made into a divergent wave, and by exciting the emission units at different positions, divergent waves with different angles can be emitted in sequence: wavefront 1, wavefront 2, and wavefront 3.

如图6所示,大孔径超声换能器阵列2由多个弧形超声换能器阵列组成,超快超声序列包括多个不同激发角度的发散波,通过横向移动虚拟源,如图6中虚拟源1、虚拟源3,并以与虚拟源相对应的相位延迟激发发射单元,可使发散波方向偏转,从而实现不同角度的发散波激发。通过将虚拟源靠近或远离阵列可以调节发散波的发散程度并以与虚拟源相对应的相位延迟激发发射单元,可以实现不同发散程度的发散波激发。 As shown in FIG6 , the large aperture ultrasonic transducer array 2 is composed of a plurality of arc-shaped ultrasonic transducer arrays, and the ultrafast ultrasonic sequence includes a plurality of divergent waves with different excitation angles. By laterally moving the virtual source, such as virtual source 1 and virtual source 3 in FIG6 , and exciting the emission unit with a phase delay corresponding to the virtual source, the divergent wave direction can be deflected, thereby achieving divergent wave excitation at different angles. The divergence degree of the divergent wave can be adjusted by moving the virtual source closer to or farther away from the array, and the emission unit can be excited with a phase delay corresponding to the virtual source, so that divergent wave excitation with different divergence degrees can be achieved.

如图7所示,大孔径超声换能器阵列2由多个超声换能器单元组成,形成球面大孔径超声换能器阵列,超快超声序列包括多个不同激发角度的发散波,如图7中的波前1、波前2、波前3,图中的tx1和tx2表示发射单元的分布范围。As shown in FIG7 , the large-aperture ultrasonic transducer array 2 is composed of a plurality of ultrasonic transducer units to form a spherical large-aperture ultrasonic transducer array. The ultrafast ultrasonic sequence includes a plurality of divergent waves with different excitation angles, such as wavefront 1, wavefront 2, and wavefront 3 in FIG7 . tx1 and tx2 in the figure represent the distribution range of the transmitting units.

如图8所示,大孔径超声换能器阵列2由多个超声换能器单元组成,形成多面体大孔径超声换能器阵列,超快超声序列包括多个不同激发角度的发散波,如图8中的波前1、波前2,图中的tx1和tx2表示发射单元的分布范围。As shown in FIG8 , the large-aperture ultrasonic transducer array 2 is composed of a plurality of ultrasonic transducer units to form a polyhedral large-aperture ultrasonic transducer array. The ultrafast ultrasonic sequence includes a plurality of divergent waves with different excitation angles, such as wavefront 1 and wavefront 2 in FIG8 . tx1 and tx2 in the figure represent the distribution range of the transmitting units.

本实施方式中的图像重建模块5可通过基于延迟求和的波束形成算法进行图像重建。所述超快超声序列中单个超声脉冲波沿某个角度激发得到的回波信号经重建可形成子图像,子图像上任意一点的灰度值为:
I(x,z)=∑iRF(i,τ(i,α,x,z),α)。
The image reconstruction module 5 in this embodiment can perform image reconstruction by a delayed-sum based beamforming algorithm. The echo signal obtained by exciting a single ultrasonic pulse wave at a certain angle in the ultrafast ultrasonic sequence can be reconstructed to form a sub-image, and the gray value of any point on the sub-image is:
I(x,z)=∑ i RF(i,τ(i,α,x,z),α).

其中,x,z为子图像上任意一点的坐标,α为超声脉冲波激发角度,RF为超声回波信号,τ为超声传播时间,不同超声脉冲波激发得到的子图像相干叠加,得到最终重建图像。i为超声换能器单元的索引,即第i个超声换能器单元。i的取值范围是从1到N,其中N是超声换能器单元的数量。Where x, z are the coordinates of any point on the sub-image, α is the ultrasonic pulse wave excitation angle, RF is the ultrasonic echo signal, τ is the ultrasonic propagation time, and the sub-images obtained by different ultrasonic pulse wave excitations are coherently superimposed to obtain the final reconstructed image. i is the index of the ultrasonic transducer unit, that is, the i-th ultrasonic transducer unit. The value range of i is from 1 to N, where N is the number of ultrasonic transducer units.

本实施方式中的超快超声序列还可为编码发射的超声脉冲波,所述编码发射在单次发射事件中同时发射多个发射信号幅度和激发角度经过编码的超声脉冲波,并在图像重建前对信号进行解码以提高图像信噪比。The ultrafast ultrasound sequence in this embodiment may also be a coded transmitted ultrasound pulse wave, wherein the coded transmission simultaneously transmits multiple ultrasound pulse waves with encoded transmission signal amplitudes and excitation angles in a single transmission event, and decodes the signal before image reconstruction to improve the image signal-to-noise ratio.

如图9所示,大孔径超声换能器阵列2由一个或多个弧形超声换能器阵列组成,单次发射事件中超快超声序列包括多个不同激发角度、不同信号幅度的平面波,空间域编码及解码的步骤如下: As shown in FIG9 , the large-aperture ultrasonic transducer array 2 is composed of one or more arc-shaped ultrasonic transducer arrays. The ultrafast ultrasonic sequence in a single emission event includes multiple plane waves with different excitation angles and different signal amplitudes. The steps of spatial domain encoding and decoding are as follows:

S1:构造哈达玛矩阵。S1: Construct the Hadamard matrix.

S2:每次发射事件中,根据哈达玛矩阵每行或每列的元素,以对应幅度权重的发射序列同时激发多个不同区域的发射单元。S2: In each emission event, according to the elements of each row or column of the Hadamard matrix, emission units in multiple different regions are simultaneously excited with an emission sequence corresponding to the amplitude weight.

S3:根据每次发射事件的幅度权重对不同发射事件的超声回波信号求和,合成单个激发角度超声脉冲波的回波信号。S3: summing the ultrasonic echo signals of different emission events according to the amplitude weight of each emission event to synthesize the echo signal of the ultrasonic pulse wave with a single excitation angle.

本申请的一种大孔径超快超声成像方法,包括如下步骤:A large-aperture ultrafast ultrasonic imaging method of the present application comprises the following steps:

步骤1:超声发射模块1生成发射脉冲序列激发大孔径超声换能器阵列2,发射脉冲序列同时或按发射延时激发大孔径超声换能器阵列上的发射单元,生成超声脉冲波,多个发射脉冲序列激发生成的多个超声脉冲波,组成一组超快超声序列。Step 1: The ultrasonic transmitting module 1 generates a transmitting pulse sequence to excite the large-aperture ultrasonic transducer array 2. The transmitting pulse sequence excites the transmitting units on the large-aperture ultrasonic transducer array simultaneously or according to the transmitting delay to generate an ultrasonic pulse wave. Multiple ultrasonic pulse waves generated by the excitation of multiple transmitting pulse sequences constitute a group of ultrafast ultrasonic sequences.

步骤2:大孔径超声换能器阵列2接收超声发射模块生成的发射脉冲序列,以更大的超声激发角度向待测体6发射超声脉冲波,覆盖目标成像范围。Step 2: The large-aperture ultrasonic transducer array 2 receives the transmission pulse sequence generated by the ultrasonic transmission module, and transmits ultrasonic pulse waves to the object to be measured 6 at a larger ultrasonic excitation angle to cover the target imaging range.

步骤3:大孔径超声换能器阵列2以更大的超声探测角度探测来自待测体的超声回波信号并传输至数据采集模块4,进行模数转换、存储、传输并输出数字信号至图像重建模块5进一步进行超声图像重建。Step 3: The large-aperture ultrasonic transducer array 2 detects the ultrasonic echo signal from the object to be tested at a larger ultrasonic detection angle and transmits it to the data acquisition module 4, performs analog-to-digital conversion, stores, transmits and outputs the digital signal to the image reconstruction module 5 for further ultrasonic image reconstruction.

可以理解,本申请是通过一些实施例进行描述的,本领域技术人员知悉的,在不脱离本申请的精神和范围的情况下,可以对这些特征和实施例进行各种改变或等效替换。另外,在本申请的教导下,可以对这些特征和实施例进行修改以适应具体的情况及材料而不会脱离本申请的精神和范围。因此,本申请不受此处所公开的具体实施例的限制,所有落入本申请的权利要求范围内的实施例都属于本申请所保护的范围内。 It is to be understood that the present application is described by some embodiments, and it is known to those skilled in the art that various changes or equivalent substitutions may be made to these features and embodiments without departing from the spirit and scope of the present application. In addition, under the guidance of the present application, these features and embodiments may be modified to adapt to specific circumstances and materials without departing from the spirit and scope of the present application. Therefore, the present application is not limited by the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of the present application are within the scope protected by the present application.

Claims (10)

一种大孔径超快超声成像系统,包括超声发射模块(1)和大孔径超声换能器阵列(2),其特征在于,所述超声发射模块(1)用于生成发射脉冲序列,所述发射脉冲序列通过不同波形的脉冲同时或按发射延时激发大孔径超声换能器阵列(2)上的发射单元,形成超声脉冲波,多个发射脉冲序列激发生成的多个超声脉冲波组成一组超快超声序列;A large-aperture ultrafast ultrasonic imaging system comprises an ultrasonic transmitting module (1) and a large-aperture ultrasonic transducer array (2), characterized in that the ultrasonic transmitting module (1) is used to generate a transmitting pulse sequence, wherein the transmitting pulse sequence excites the transmitting units on the large-aperture ultrasonic transducer array (2) with pulses of different waveforms simultaneously or according to a transmitting delay to form an ultrasonic pulse wave, and the multiple ultrasonic pulse waves generated by the excitation of multiple transmitting pulse sequences constitute a group of ultrafast ultrasonic sequences; 所述大孔径超声换能器阵列(2)包括多个超声换能器单元,所述超声换能器单元用于接收超声发射模块生成的发射脉冲序列,并将发射脉冲序列转换为超声脉冲波向待测体发射,所述超声脉冲波在待测体内传播过程中发生反射、散射,最终传播至大孔径超声换能器阵列(2)被其接收并转换为超声回波信号。The large-aperture ultrasonic transducer array (2) comprises a plurality of ultrasonic transducer units, wherein the ultrasonic transducer units are used to receive a transmission pulse sequence generated by an ultrasonic transmission module, and convert the transmission pulse sequence into an ultrasonic pulse wave for transmission to the object to be measured. The ultrasonic pulse wave is reflected and scattered during propagation in the object to be measured, and finally propagates to the large-aperture ultrasonic transducer array (2), is received by the array and converted into an ultrasonic echo signal. 根据权利要求1所述的一种大孔径超快超声成像系统,其特征在于,所述大孔径超声换能器阵列(2)上不同超声换能器单元的成像区域内任意一点超声传播方向的最大角度差异在60°以上。A large-aperture ultrafast ultrasonic imaging system according to claim 1, characterized in that the maximum angular difference in the ultrasonic propagation direction at any point in the imaging area of different ultrasonic transducer units on the large-aperture ultrasonic transducer array (2) is greater than 60°. 根据权利要求1所述的一种大孔径超快超声成像系统,其特征在于,所述大孔径超声换能器阵列(2)包括以下几种形式:一个或多个弧形超声换能器阵列组成弧形大孔径超声换能器阵列;多个线性超声换能器阵列组成线性大孔径超声换能器阵列;多个超声换能器单元在空间中排布形成球面大孔径超声换能器阵列或多面体大孔径超声换能器阵列。A large-aperture ultrafast ultrasonic imaging system according to claim 1, characterized in that the large-aperture ultrasonic transducer array (2) includes the following forms: one or more arc-shaped ultrasonic transducer arrays form an arc-shaped large-aperture ultrasonic transducer array; multiple linear ultrasonic transducer arrays form a linear large-aperture ultrasonic transducer array; multiple ultrasonic transducer units are arranged in space to form a spherical large-aperture ultrasonic transducer array or a polyhedral large-aperture ultrasonic transducer array. 根据权利要求1所述的一种大孔径超快超声成像系统,其特征在于,所述超快超声序列包括一个或多个超声脉冲波,每个超声脉冲波在传播过程中完全覆盖并激发成像区域,在发射脉冲序列控制下,所述超声脉冲波为单一激发角度或多个不同激发角度的发散波、平面波、聚焦波的任意组合,通过改变发射延时或激发不同位置处的发射单元改变超声脉冲波的激发角度,所述聚焦波、平面波或发散波激发角度可变范围在-90°到90°之间。A large-aperture ultrafast ultrasonic imaging system according to claim 1, characterized in that the ultrafast ultrasonic sequence includes one or more ultrasonic pulse waves, each ultrasonic pulse wave completely covers and excites the imaging area during propagation, and under the control of the emission pulse sequence, the ultrasonic pulse wave is any combination of a single excitation angle or a plurality of divergent waves, plane waves, and focused waves with different excitation angles, and the excitation angle of the ultrasonic pulse wave is changed by changing the emission delay or exciting the emission units at different positions, and the variable range of the excitation angle of the focused wave, plane wave or divergent wave is between -90° and 90°. 根据权利要求1所述的一种大孔径超快超声成像系统,其特征在于,还包括数据采集模块(4),所述数据采集模块(4)用于接收超声回波信号,实现模拟放大、模数转换、存储、传输并输出数字信号至图像重建模块。 The large-aperture ultrafast ultrasonic imaging system according to claim 1 is characterized in that it also includes a data acquisition module (4), wherein the data acquisition module (4) is used to receive ultrasonic echo signals, realize analog amplification, analog-to-digital conversion, storage, transmission and output digital signals to the image reconstruction module. 根据权利要求5所述的一种大孔径超快超声成像系统,其特征在于,还包括系统控制模块(3),所述系统控制模块(3)用于控制所述发射单元的数量、分布和所述发射脉冲序列性质、发射延时和所述数据采集模块(4)的模拟放大增益、采样率参数。A large-aperture ultrafast ultrasonic imaging system according to claim 5, characterized in that it also includes a system control module (3), wherein the system control module (3) is used to control the number and distribution of the transmitting units, the properties of the transmitting pulse sequence, the transmitting delay, and the analog amplification gain and sampling rate parameters of the data acquisition module (4). 根据权利要求6所述的一种大孔径超快超声成像系统,其特征在于,还包括图像重建模块(5),所述图像重建模块(5)通过基于延迟求和的波束形成算法进行图像重建。The large-aperture ultrafast ultrasonic imaging system according to claim 6 is characterized in that it also includes an image reconstruction module (5), wherein the image reconstruction module (5) performs image reconstruction by using a delay-sum-based beamforming algorithm. 根据权利要求7所述的一种大孔径超快超声成像系统,其特征在于,所述图像重建模块(5)通过超快超声序列中单个超声脉冲波沿某个角度激发得到的回波信号重建形成子图像,子图像上任意一点的灰度值为:
I(x,z)=∑iRF(i,τ(i,α,x,z),α);
The large-aperture ultrafast ultrasonic imaging system according to claim 7 is characterized in that the image reconstruction module (5) reconstructs the echo signal obtained by exciting a single ultrasonic pulse wave along a certain angle in the ultrafast ultrasonic sequence to form a sub-image, and the gray value of any point on the sub-image is:
I(x,z)=∑ i RF(i,τ(i,α,x,z),α);
其中,x,z为子图像上任意一点的坐标,α为超声脉冲波激发角度,RF为超声回波信号,τ为超声传播时间,不同超声脉冲波激发得到的子图像相干叠加,得到最终重建图像;i为超声换能器单元的索引;Where x, z are the coordinates of any point on the sub-image, α is the ultrasonic pulse wave excitation angle, RF is the ultrasonic echo signal, τ is the ultrasonic propagation time, and the sub-images obtained by different ultrasonic pulse wave excitations are coherently superimposed to obtain the final reconstructed image; i is the index of the ultrasonic transducer unit; 所述超快超声序列为编码发射的超声脉冲波,所述编码发射在单次发射事件中同时发射多个发射信号幅度和激发角度经过编码的超声脉冲波,并在图像重建前对信号进行解码。The ultrafast ultrasound sequence is a coded transmitted ultrasound pulse wave, wherein the coded transmission simultaneously transmits a plurality of ultrasound pulse waves with coded transmission signal amplitudes and excitation angles in a single transmission event, and decodes the signal before image reconstruction.
根据权利要求8所述的一种大孔径超快超声成像系统,其特征在于,所述大孔径超声换能器阵列(2)由一个或多个弧形超声换能器阵列组成,单次发射事件中超快超声序列包括多个不同激发角度、不同信号幅度的平面波,空间域编码及解码的步骤如下:A large-aperture ultrafast ultrasonic imaging system according to claim 8, characterized in that the large-aperture ultrasonic transducer array (2) is composed of one or more arc-shaped ultrasonic transducer arrays, the ultrafast ultrasonic sequence in a single emission event includes a plurality of plane waves with different excitation angles and different signal amplitudes, and the steps of spatial domain encoding and decoding are as follows: S1:构造哈达玛矩阵;S1: construct Hadamard matrix; S2:每次发射事件中,根据哈达玛矩阵每行或每列的元素,以对应幅度权重的发射序列同时激发多个不同区域的发射单元;S2: In each emission event, according to the elements of each row or column of the Hadamard matrix, the emission units in multiple different regions are excited simultaneously with the emission sequence corresponding to the amplitude weight; S3:根据每次发射事件的幅度权重对不同发射事件的超声回波信号求和,合成单个激发角度超声脉冲波的回波信号。S3: summing the ultrasonic echo signals of different emission events according to the amplitude weight of each emission event to synthesize the echo signal of the ultrasonic pulse wave with a single excitation angle. 一种如权利要求1-9任一项所述的大孔径超快超声成像系统的超快超声成像方法,其特征在于,包括如下步骤: An ultrafast ultrasonic imaging method of a large-aperture ultrafast ultrasonic imaging system according to any one of claims 1 to 9, characterized in that it comprises the following steps: 步骤1:超声发射模块(1)生成发射脉冲序列激发大孔径超声换能器阵列(2),发射脉冲序列同时或按发射延时激发大孔径超声换能器阵列上的发射单元,生成超声脉冲波,多个发射脉冲序列激发生成的多个超声脉冲波,组成一组超快超声序列;Step 1: The ultrasonic transmitting module (1) generates a transmitting pulse sequence to excite the large-aperture ultrasonic transducer array (2), wherein the transmitting pulse sequence excites the transmitting units on the large-aperture ultrasonic transducer array simultaneously or according to the transmitting delay to generate ultrasonic pulse waves, and multiple ultrasonic pulse waves generated by the excitation of multiple transmitting pulse sequences constitute a group of ultrafast ultrasonic sequences; 步骤2:大孔径超声换能器阵列(2)接收超声发射模块(1)生成的发射脉冲序列,以大孔径的超声激发角度向待测体发射超声脉冲波,覆盖目标成像范围;Step 2: The large-aperture ultrasonic transducer array (2) receives the transmission pulse sequence generated by the ultrasonic transmission module (1), and transmits ultrasonic pulse waves to the object to be measured at a large-aperture ultrasonic excitation angle to cover the target imaging range; 步骤3:大孔径超声换能器阵列(2)以大孔径的超声探测角度探测来自待测体的超声回波信号并传输至数据采集模块,进行模数转换、存储、传输并输出数字信号至图像重建模块(5)进一步进行超声图像重建。 Step 3: The large-aperture ultrasonic transducer array (2) detects the ultrasonic echo signal from the object to be measured at a large-aperture ultrasonic detection angle and transmits it to the data acquisition module, performs analog-to-digital conversion, stores, transmits and outputs the digital signal to the image reconstruction module (5) for further ultrasonic image reconstruction.
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