[go: up one dir, main page]

WO2025085806A1 - Bases pour lentilles intraoculaires de réception à composants multiples et procédés associés - Google Patents

Bases pour lentilles intraoculaires de réception à composants multiples et procédés associés Download PDF

Info

Publication number
WO2025085806A1
WO2025085806A1 PCT/US2024/052058 US2024052058W WO2025085806A1 WO 2025085806 A1 WO2025085806 A1 WO 2025085806A1 US 2024052058 W US2024052058 W US 2024052058W WO 2025085806 A1 WO2025085806 A1 WO 2025085806A1
Authority
WO
WIPO (PCT)
Prior art keywords
optical
aiol
base
component
coupled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/052058
Other languages
English (en)
Inventor
Stuart William WENZEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shifamed Holdings LLC
Original Assignee
Shifamed Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shifamed Holdings LLC filed Critical Shifamed Holdings LLC
Publication of WO2025085806A1 publication Critical patent/WO2025085806A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/12—Fluid-filled or evacuated lenses
    • G02B3/14—Fluid-filled or evacuated lenses of variable focal length
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/1682—Intraocular lenses having supporting structure for lens, e.g. haptics having mechanical force transfer mechanism to the lens, e.g. for accommodating lenses

Definitions

  • the present technology relates to bases for multi-component accommodating intraocular lenses and associated methods for making and using such devices.
  • Cataracts can affect a large percentage of the worldwide adult population with clouding of the native crystalline lens and resulting loss of vision.
  • Patients with cataracts can be treated by native lens removal and surgical implantation of an intraocular lens (IOL).
  • IOL intraocular lens
  • multi-focal lOLs have been developed to address these drawbacks, but they too can have their own drawbacks.
  • multi-focal lOLs generally perform well for reading and distance vision, in at least some instances multi-focal lOLs may cause significant glare, halos, reduced contrast sensitivity, and other visual artifacts.
  • AIOLs have been proposed to provide accommodative optical power.
  • prior AIOLs can provide insufficient accommodation after implantation or produce suboptimal refractive correction of the eye.
  • the amount of accommodation of the prior AIOLs can also decrease after implantation in at least some instances.
  • the prior AIOLs can also be too large to be inserted through a small incision of the eye and may require the incision to be somewhat larger than would be ideal.
  • at least some of the prior AIOLs can be unstable when placed in the eye, which can lead to incorrect accommodation and other errors.
  • Improved implantable intraocular lenses that accommodate with the natural mechanisms of controlling focusing of the eye that overcome at least some of the above deficiencies would be desirable.
  • improved AIOLs would provide increased amounts of accommodation when implanted, provide refractive stability, introduce few if any perceptible visual artifacts, and allow the optical power of the eye to change from far vision to near vision in response to the distance of the object viewed by the patient.
  • FIG. 1A is a partially exploded perspective views of an AIOL configured in accordance with embodiments of the present technology.
  • FIG. IB is a side cross-sectional of the AIOL taken along line 1B-1B of FIG. 1A.
  • FIG. 2A is a perspective view of an AIOL configured in accordance with embodiments of the present technology.
  • FIG. 2B is a top view of the AIOL of FIG. 2A.
  • FIG. 2C is a side view of the AIOL of FIG. 2A.
  • FIG. 2D is a side cross-sectional view of a base of the AIOL of FIG. 2A positioned within a capsular bag of a patient’s eye in accordance with embodiments of the present technology.
  • FIG. 2E is a perspective view of an anterior component the AIOL of FIG. 2A and a stiffening ring configured in accordance with embodiments of the present technology.
  • FIG. 2F is a perspective view of a posterior component of the AIOL of FIG. 2A and another stiffening ring configured in accordance with embodiments of the present technology.
  • FIGS. 3A-3C are perspective, top, and side views, respectively, of another base of an AIOL configured in accordance with embodiments of the present technology.
  • FIGS. 4A-4C are perspective, top, and side views, respectively, of yet another base of an AIOL configured in accordance with embodiments of the present technology.
  • FIGS. 5A-5C are perspective, top, and side views, respectively, of a further base of an AIOL configured in accordance with embodiments of the present technology.
  • FIG. 6A is a side cross-sectional view of another base of an AIOL configured in accordance with embodiments of the present technology.
  • FIG. 6B is an enlarged view of a tab and an outer fluid reservoir of the base of FIG. 6A.
  • FIG. 7A is a perspective cross-sectional view of an AIOL configured in accordance with embodiments of the present technology.
  • FIG. 7C is a bottom view of a first component of a base of the AIOL of FIG. 7A in accordance with embodiments of the present technology.
  • FIG. 7D is a top view of a second component of a base of the AIOL of FIG. 7A in accordance with embodiments of the present technology.
  • FIGS. 7E-7G illustrate alternate arrangements for castles of the AIOL of FIG. 7A in accordance with embodiments of the present technology.
  • the present technology is directed to bases for multi-component accommodating intraocular lenses (AIOLs) and associated methods for making and using such devices.
  • the AIOLs include a base that (i) defines an accommodating or adjustable power lens and (ii) is configured to receive another, replaceable or exchangeable lens having a fixed optical power.
  • the accommodating lens can include an optical fluid chamber defined by the base and configured to change shape and/or volume, e.g., in response to forces from the patient’s eye.
  • the base can be implanted within a capsular bag of a patient’s eye and configured to react one or more forces from the capsular bag to adjust or change the optical power of the accommodating lens.
  • the base can include one or more tabs coupled to an outer wall portion of the base and configured to place the capsular bag in tension (e.g., against the one or more tabs) when the AIOL is implanted within the capsular bag. Placing the capsular bag in tension can, in at least some embodiments, cause the outer wall portion of the base to deflect inwardly (e.g. , toward a central and/or optical axis of the base) and increase a curvature and/or a volume of the optical fluid chamber to thereby increase the optical power of the accommodating lens.
  • the bases of the present technology are expected to have an improved and/or maximized response to forces from the eye.
  • the tabs can be configured to concentrate forces from the eye centrally on the outer wall portion of the base to increase the deformation produced in response to forces from the eye.
  • the outer wall portion can have reduced curvature which, in turn, is expected to increase the deformability of the outer wall portion in response to forces from the eye.
  • FIGS. 1A-7G Specific details of various embodiments of the present technology are described below with reference to FIGS. 1A-7G. Although many of the embodiments are described below with respect to AIOLs and associated methods, other embodiments are within the scope of the present technology. Additionally, other embodiments of the present technology can have different configurations, components, and/or procedures than those described herein. For instance, AIOLs configured in accordance with the present technology may include additional elements and features beyond those described herein, or other embodiments may not include several of the elements and features shown and described herein.
  • FIG. 1A is a partially exploded perspective view of an adjustable or accommodating intraocular lens 100 (“AIOL 100”) configured in accordance with embodiments of the present technology.
  • the AIOL 100 can include an adjustable or base lens structure 102 (“base 102”) and a fixed power and/or fixed depth of focus lens 104 (“fixed lens 104”) that can be removably coupled to the base 102.
  • the fixed lens 104 includes one or more tabs 118 (FIG. IB) that can fit into one or more grooves, slots, or other fixed lens receiving feature 112 extending radially outward toward an outer perimeter of the base 102.
  • the slots 1 12 in the base 102 can allow the fixed lens 104 to be replaced or exchanged with another fixed lens, e.g., while the base 102 is positioned within a capsular bag of a patient’s eye.
  • the base 102 can include one or more flow-through features 114.
  • the embodiment of the AIOL 100 illustrated in FIG. 1A comprises three outer flow-through features 114, but in other embodiments the AIOL 100 can include a greater or lesser number of flow-through features 114.
  • Each of the outer flow- through features 114 can include detents, such as recesses, distributed circumferentially along the perimeter of the base 102 and/or an anterior surface of the base 102.
  • the flow-through features 114 can create passages between the outer perimeter of the AIOL 100 and an inner surface of an eye capsule (not shown) in which the AIOL 100 is implanted.
  • each of the flow-through features 1 14 can allow fluid (e.g., within the capsular bag) to flow around an outer perimeter of the AIOL 100, such as from a posterior side of the AIOL 100 toward and/or to an anterior side of the AIOL 100.
  • the outer flow-through features 114 may additionally provide rotational constraint to maintain the rotational orientation of the base 102 with respect to the capsular bag when implanted therein.
  • FIG. IB is a cross-section of the base 102 taken along line 1B-1B of FIG. 1A.
  • the base 102 can include a first or anterior component 106 and a second or posterior component 108 that can be coupled together (e.g., via adhesives) to form the base 102.
  • the base 102 can define a first fluid chamber or reservoir 122 and a second fluid chamber or reservoir 124, each of which can be filled with a fluid.
  • the fluid can have a refractive index between about 1 and about 2, such as at least 1.33 and/or one or more other suitable refractive indices.
  • a channel 126 can extend between and fluidly couple the outer fluid reservoir 122 and the inner fluid reservoir 124 to allow the fluid to flow between the outer fluid reservoir 122 and the inner fluid reservoir 124.
  • the outer fluid reservoir 122 can be defined at least partially between a first or outer wall 128 and a second or inner wall 130 of the first component 106 and/or a first or outer wall 132 and a second or inner wall 134 of the second component 108.
  • the inner wall 130 can at least partially define one or more of the slots 112 in the base 102, e.g., a radially outer surface of the inner wall 130 can be in contact with fluid within the outer fluid reservoir 122 and a radially inner surface of the inner wall 130 can be in contact with the fixed lens 104 (FIG. 1A) when the fixed lens 104 is received within the base 102.
  • the base 102 can include an adjustable lens 136 at least partially defined by the inner fluid reservoir 124 (and, e.g., the fluid contained therein), a first optical portion 138 of the first component 106 of the base 102, and a second optical portion 140 of the second component 108 of the base 102.
  • the first and/or second optical portions 138, 140 can define a shape of the inner fluid reservoir 124 and the fluid within the inner fluid reservoir 124 can conform to that shape to provide an optical power.
  • the first and/or second optical portions 138, 140 can bend or flex, changing the shape and/or volume of the inner fluid reservoir 124.
  • the change in shape of the inner fluid reservoir 124 can change the shape and/or volume of the fluid within the inner fluid reservoir 124 and thereby change the optical power provided by the adjustable lens 136.
  • the adjustable lens 136 can be positioned posterior to the fixed lens 104 and/or the lens portion 1 16 thereof.
  • One or both of the first optical portion 138 and the second optical portion 140 can be planar members or optical membranes. In at least some embodiments, for example, the first and/or second optical portions 138, 140 contribute zero, or substantially zero, optical power to the overall optical correction provided by the base 102.
  • one or both of the first and/or second optical portions 138, 140 can include a lens configured to provide a positive or negative optical correction (e.g., an optical power of up to ⁇ 1 D, 2 D, 3 D, 4 D, 5 D, 6D, 7D, 8D, 9D, 10D, etc.) as needed.
  • the adjustable lens 136 has a diopter of between about 5 D and about 7.5 D, such as between about 5.8 D and about 7.3D, any diopter therebetween, or another suitable diopter. Additionally, or alternatively, the diopter of the adjustable lens 136 can have a range of adjustment of up to 1.5D, 3D, 4D, 5D, 7.5D, any range therebetween, or another suitable range.
  • FIG. 2A is a perspective view of another AIOL 200 configured in accordance with embodiments of the present technology.
  • the AIOL 200 can be at least generally similar or identical in structure and/or function to the AIOL 100 of FIGS. 1A and IB.
  • the AIOL 200 can include a base 202 defining a lens-receiving area or volume 210, one or more flow-through features 214 (individually identified in FIG. 2B as first through third flow-through features 214a-c, respectively), and/or an outer fluid chamber 222 (FIG. 2B, shown at least partially schematically).
  • the base 202 can include a first or anterior component 206, a second or posterior component 208, and/or a first optical portion 238.
  • the AIOL 200 can include one or more haptic contact members or tabs 242 (individually identified as a first tab 242a, a second tab 242b, and a third tab 242c).
  • Each of the tabs 242 can include an outer contact portion 244 and a connector portion 246 extending inwardly (e.g., radially inwardly) from the outer contact portion 244 to operably couple the outer contact portion 244 to the rest of the base 202.
  • the tabs 242 can be divided between the first component 206 and the second component 208, e.g., such that the first component 206 includes a first or anterior portion 248 of the tabs 242 and the second component 208 includes a second or posterior portion 250 of the tabs 242.
  • the tabs 242 and/or the outer contact portion 244 thereof can be configured to contact tissue (e.g., an interior surface of a capsular bag) of a patient’s eye when the AIOL 200 is positioned/implanted within the patient’s eye (FIG.
  • the tabs 242 define a circular, or at least substantially circular, outermost perimeter of the AIOL 200. In other embodiments, the tabs 242 may protrude outside of a circle around the rest of the base such that they sustain proportionally more of the capsular force/tension from the patient’s eye than one or more other portions of the base 202.
  • FIG. 2B is a top view of the AIOL 200.
  • the AIOL 200 can include multiple regions or sections (e.g., radially-defined regions or section).
  • the AIOL 200 includes one or more haptic regions 252 (individually identified as a first haptic region 252a, a second haptic region 252b, and a third haptic region 252c) and one or more flow-through regions 254 (individually identified as a first flow-through region 254a, a second flow-through region 254b, and a third flow-through region 254c).
  • Each of the haptic regions 252 can separate and/or be positioned at least partially between two of the flow-through regions 254. Accordingly all, or at least a portion, of the base 202 can be radially symmetrical relative to a central and/or optical axis A (“axis A”) defined by the base 202. In these and/or other embodiments, the haptic regions 252 and/or the flow-through regions 254 can have one or more other suitable positions relative to one another.
  • Each of the haptic regions 252 can include an outer wall portion 256 (individually identified as a first outer wall portion 256a, a second outer wall portion 256b, and a third outer wall portion 256c) of the base 202, a corresponding portion of the outer fluid chamber 222, and/or one or more of the tabs 242, e.g., coupled to outer wall portion 256.
  • the outer wall portions 256 can have different (e.g., reduced) curvature compared to one or more other portions of the AIOL 200.
  • the first optical portion 238 has a first radius of curvature R1 and the outer wall portions 256 have a second radius of curvature R2 (shown with reference to the first outer wall portion 256a) greater than the first radius of curvature Rl.
  • the first radius of curvature R1 can be centered at or along the axis A of the base 202.
  • the second radius of curvature R2 can have a center of curvature C at an offset O from the axis A.
  • the offset O can be a distance between about 0.5 mm and about 3 mm, such as up to 1 mm, 1.5 mm, 2 mm, 2.5 mm, any value between any two preceding values, and/or one or more other suitable distances.
  • the first radius of curvature is between about 2 mm and about 5 mm, such as up to 2.5 mm, 3 mm, 3.5 mm, 4 mm, 4.5 mm, any value between any two preceding values, and/or one or more other suitable radii of curvature.
  • the second radius of curvature R2 can be between about 3 mm and about 7 mm, such as up to 3.5 mm, 4 mm, 4.5 mm, 5 mm, 5.5 mm, 6 mm, 6.5 mm, any value between any two preceding values, and/or one or more other suitable radii of curvature.
  • the increased radius of curvature of the outer wall portions 256 relative to the first optical portion 238 and/or the offset O of the center of curvature C of the outer wall portions 256 can lead to the outer wall portions 256 being “flatter” and/or having relatively reduced curvature, e.g., compared to embodiments in which the outer wall portions 256 shares the first radius of curvature Rl.
  • the reduced curvature of the outer wall portions 256 is expected to increase the compliance and/or responsiveness of the outer wall portions 256 to forces from the patient’s eye.
  • the outer wall portions 256 can have one or more flat or planar sections, e.g., that are not curved and do not have a radius of curvature.
  • the reduced curvature of the flat or planar sections is expected to decrease the resistance to bending/flexing of the outer wall portions 256 and/or increase (i) the degree to which the outer wall portions 256 react forces from the patient’s eye (e.g., deform inwardly) and/or (ii) the volume displaced from within the outer fluid chamber 222 for at least the same reasons as discussed above.
  • the tabs 242 can receive forces from the patient’s eye (e.g., from the capsular bag, via the outer contact portions 244; FIG. 2A) and transmit the received forces to the outer wall portions 256, e.g., to bend/deflect the outer wall portions 256 as described above.
  • the reduced size (e.g., cross-sectional area) of the connector portions 246 (FIG. 2A) of the tabs 242 relative to the outer contact portions 244 is expected to concentrate forces from the eye on a center or central region of the outer wall portions 256, e.g., to achieve an increased or maximized deflection and/or accommodative response.
  • one or more of the tabs 242 can be in fluid communication with the outer fluid chamber 222.
  • one or more of the tabs 242 are hollow and configured to exchange fluid with the outer fluid chamber 222. Accordingly, forces from the patient’s eye can deform the tabs 242 and cause all, or at least a portion, of the fluid contained therein to flow radially inwardly, e.g., toward and/or into the outer fluid chamber 222. This is described in greater detail below with reference to at least FIGS. 6A and 6B.
  • FIG. 2C is a side view of the AIOL 200.
  • the first outer wall portion 256a and/or one or more of the other outer wall portions 256 can include a central region 258 and one or more edge or corner regions 260 (individually identified as a first or anterior corner region 260a and a second or posterior corner region 260b).
  • the central region 258 can be annular, or at least generally annular, and extend about the axis A. In some embodiments, the central region 258 is curved in only one direction, e.g., about the axis A.
  • the corner regions 260 can be positioned on either side (e.g., opposing sides) of the central region 258 and be curved about the axis A and relative to the central region 258, e.g., inwardly toward the axis A.
  • This increased curvature of the comer regions 260 can increase their stiffness and/or make the comer regions 260 comparatively more resistant to bending/deformation in response to forces from the patient’s eye, e.g., relative to the central region 258.
  • the comer regions 260 can occupy a reduced fraction of a height of the outer wall portion 256, e.g., compared to other accommodating intraocular lens.
  • the outer wall portion 256a can have a first dimension (e.g., height, length, etc.) Hl
  • the central region 258 can have a second dimension (e.g., height, length, etc.) less than the first dimension Hl.
  • the difference between the first dimension Hl and the second dimension H2 can correspond to the combined dimension of the comer regions 260.
  • the corner regions 260 occupy less than 40%, 30%, 20%, 10%, 5%, any value therebetween, and/or one or more other suitable percentages of the first dimension Hl.
  • the second dimension H2 can occupy up to 60%, 70%, 80%, 90%, 95%, any value therebetween, and/or one or more other suitable percentages of the first dimension Hl.
  • Increasing the second dimension H2 is expected to reduce the resistance to bending/deformation of the outer wall portion 256, e.g., in response to forces from the patient’s eye which, in turn, is expected to improve or maximize the accommodative response of the AIOL 200. Accordingly, in at least some embodiments the improved/maximized accommodative response of the base 202 is expected to provide improved optical correction and/or allow a single base size to adjust to fit an increase range of capsular bag sizes.
  • the first component 206 and the second component 208 can be coupled (e.g., bonded) to one another at a joint or seam 262.
  • the seam 262 can extend around all, or at least a portion, of the perimeter of the base 202.
  • the seam 262 can be located at, or at least proximate to, a midpoint of the outer wall portion 256, e.g., half of the first dimension Hl from an anterior-most surface of the base 202.
  • FIG. 2D is an enlarged side cross-sectional view of a portion of the base 202 positioned within a capsular bag C of a patient’s eye in accordance with embodiments of the present technology.
  • One or more zonules Z (individually identified as first through fourth zonules Z1-Z4, respectively) can be coupled to the capsular bag C at or near an equatorial region E of the capsular bag C.
  • the zonules Z can apply a force to the capsular bag C to change an accommodative state of the patient’s eye.
  • the base 202 can respond to the presence and/or the absence of the force from the zonules Z, e.g., to change the optical power provided by the base 202.
  • the zonules Z are in tension and stretch/elongate the capsular bag C, e.g., in a radially outward direction DI toward and/or to a state of “dis-accommodation.”
  • the tabs 242 and the outer wall portions 256 can move in the radially outward direction DI, e.g., with or in response to the stretching/elongation of the capsular bag C.
  • the tabs 242 and/or the outer wall portions 256 can move in the radially outward direction DI on their own, e.g., to fill or at least partially occupy space created between the capsular bag C and the tabs 242 when the zonules stretch/elongate the capsular bag C.
  • the tabs 242 and/or the outer wall portions 256 can be coupled to the capsular bag C, e.g., via one or more adhesives, stiction, electrostatic adhesive forces, friction, fluidic mechanisms (squeezefilm, viscous), physiological adhesion, fibrosis, etc., so that the radially-outward movement of the capsular bag C draws/pulls the tabs 242 radially outwardly in tandem.
  • the tabs 242 can be configured to rotationally anchor the base 202 to the capsular bag C, e.g., to prevent, or at least partially prevent, the base 202 from rotating relative to the capsular bag C when implanted therein.
  • the radially outward movement of the labs 242 and the outer wall portions 256 can, in turn, redistribute within the base 202 from the optical fluid chamber 224 toward and/or into the outer fluid chamber 222, changing a shape (e.g., reducing the curvature) of the optical fluid chamber 224 and/or changing (e.g., reducing) a volume of fluid contained within the optical fluid chamber 224 to thereby reduce the optical power of the base 202.
  • the change in shape and/or volume of fluid within the optical fluid chamber 224 can account for all, or at least substantially all, the change in optical power of the base 202.
  • the change in shape and/or volume of fluid within the optical fluid chamber 224 can account for at least 70%, 80%, 90%, 95%, 100% any value therebetween, and/or one or more other suitable percentage changes to the optical power of the base 202.
  • the radially outward movement of the tabs 242 and the outer wall portions 256 can change (e.g., reduce) a curvature of the first optical portion 238 and/or the second optical portion 240.
  • the first optical portion 238 and/or the second optical portion 240 can themselves have an optical power or provide no, or substantially no, optical power. Additionally, or alternatively, the change in curvature of the first optical portion 238 and/or the second optical portion 240 can contribute to the change in optical power of the base 202, or account for none of, or substantially none of, the change in the optical power of the base 202.
  • the first optical portion 238 and/or the second optical portion 240 change curvature in response to a change in force on the capsular bag C, but the change in curvature does not, or substantially does not, change the optical power of the base 202.
  • the change in curvature of the first optical portion 238 and/or the second optical portion 240 can account for no more than 30%, 20%, 10 %, 5%, 0%, any value therebetween, and/or one or more other suitable percentage changes to the optical power of the base 202.
  • the zonules Z can relax, e.g., from the state of tension described previously, to allow the capsular bag C to return/shorten (e.g., at least partially elastically) in a radially inward direction D2, e.g., toward and/or to a state of “accommodation.”
  • the tabs 242 and the outer wall portions 256 can move in the radially inward direction D2, e.g., with or in response to the radially shortening of the capsular bag C.
  • the radial shortening of the capsular bag C can place all, or at least a portion (e.g., the equatorial portion E) of the capsular bag C in tension against the base 202, with at least some or all of the tensile force being applied to the tabs 242.
  • the base 202 has a maximum outer circumference (e.g., defined by the tabs 242) greater than an equatorial circumference of the capsular bag C when the capsular bag C is in the accommodated state.
  • the base 202 can deform, stretch, and/or otherwise bias the capsular bag C in the radially-outward direction DI when positioned therein and, in turn, the capsular bag C can pre-load tension against the base 202.
  • the radially inward force against tabs 242 from the capsular bag C can drive the tabs 242 in the radially inward direction D2 to deflect the outer wall portion 256 inwardly, shown as dashed-line deflected outer wall portion 256a'.
  • the deflection of the outer wall portion 256a can change (e.g., reduce) a volume of the outer fluid chamber 222 to redistribute fluid in the radially inward direction D2, e.g., from the outer fluid chamber 222 toward and/or into the optical fluid chamber 224.
  • the central positioning of the connector portion 246 on the outer wall portion 256 can concentrate the force from the capsular bag C centrally on the outer wall portion 256, e.g., to increase or maximize the deflection of the outer wall portion 256 as the capsular bag C transitions toward and/or to the accommodated state.
  • the volume of fluid within the optical fluid chamber 224 increases and, in response, the first optical portion 238 and/or the second optical portion 240 can deflect or otherwise change (e.g., increase) curvature to accommodate the increased volume of fluid, shown as dashed-line anteriorly- deflected first optical portion 238' and dashed-line posteriorly-deflected second optical portion 240'.
  • the curvatiire/dcfleclion of the deflected first and second optical portions 238', 240' can change the shape (e.g., increase the curvature) of the fluid within the optical fluid chamber 224 and thereby change (e.g., increase) the optical power of the base 202.
  • the change in shape and/or volume of fluid within the optical fluid chamber 224 accounts for all, or substantially all, of the change in optical power of the base 202, e.g., with the first and/or second optical portions 238, 240 providing no or substantially no optical power and/or the change in curvature of the first and/or second optical portions 238, 240 accounting for none of, or substantially none of, the change in optical power.
  • the first and/or second optical portions 238, 240 can be configured to have some optical power and/or such that the change in curvature of the first and/or second optical portion 238, 240 accounts for at least a portion of the change in optical power of the base 202.
  • FIG. 2E is a perspective view of the first component 206 of the AIOL 200.
  • the AIOL 200 can further include a stiffening ring 270 configured to be coupled to, over-molded into, and/or otherwise joined with the first component 206. In the illustrated embodiment, for example, the stiffening ring 270 is coupled to the first optical portion 238 of the first component 206.
  • the stiffening ring 270 can include polyetheretherketone (PEEK), nylon, Ultem ® or polyetherimide (PEI), nitinol, stainless steel, and/or one or more other generally resilient and/or medial grade polymers and/or metals.
  • the stiffening ring 270 can have a thickness (as measured parallel to the axis A) of between about 10 pm and about 100 pm, such as at least 10 pm, 20 pm, 30 pm, 40 pm, 50 pm, 60 pm, 70 pm, 80 pm, 90 pm, and/or any thickness therebetween.
  • the stiffening ring 270 can include one or more perforations and/or other features configured to facilitate coupling the stiffening ring 270 to the first component 206.
  • the stiffening ring 270 can be annularly shaped so as to define a central opening 272. Accordingly, the stiffening ring 270 can be coupled to an outer or peripheral region 238a of the first optical portion 238 such that the central opening 272 is aligned with an inner region 238b of the first optical portion 238.
  • the stiffening ring 270 can have a first modulus of elasticity greater than a second modulus of elasticity of the first optical portion 238. Accordingly, the stiffening ring 270 can be configured to reduce or prevent bending or flexion of the peripheral region 238a of the first optical portion 238 when, e.g., the stiffening ring 270 is coupled to the peripheral region 238a of the first optical portion 238.
  • the stiffening ring 270 can be configured to maintain the flatness of the peripheral region 238a, and/or maintain the peripheral region 238a in an at least generally flat state. Reducing the bending/flexion and/or maintaining the flatness of the peripheral region 238a is expected to reduce or prevent all or a subset of any optical distortions caused by bending/flexion of the peripheral region 238a when, e.g., the AIOL 200 accommodates in response to one or more forces from the eye.
  • the stiffening ring 270 can be configured to be coupled to an anterior and/or posterior side of the first component 206.
  • the stiffening ring 270 can, accordingly, be configured to be seated against one or more features on the anterior or posterior side of the first component 206.
  • the posterior side of the first component 206 includes one or more castles or spacing members 207 extending posteriorly beyond/relative to the first optical portion 238.
  • Each of the castles 207 can be configured to space the first optical portion 238 apart from the second optical portion 240 (FIG. 2D) when the first component 206 is coupled to the second component 208 (FIG. 2D) so as to at least partially define the optical fluid chamber 224 (FIG. 2D).
  • the stiffening ring 270 can include one or more notches 274 (e.g., as many notches 274 as there are castles 207), each of which can be configured to receive a corresponding one of the castles 207 to securely seat the stiffening ring 270 around the peripheral region 238a and against the posterior side of the first optical portion 238.
  • notches 274 e.g., as many notches 274 as there are castles 207
  • the stiffening ring 270 When coupled to the posterior side of the first component 206, the stiffening ring 270 can be positioned at least partially within the optical fluid chamber 224 (FIG. 2D) when, e.g., the first component 206 is coupled to the second component 208 (FIG. 2D). Accordingly, a thickness of the stiffening ring 270 (as measured parallel to the axis A) can be less than a height of one or more of the castles 207 (as measured parallel to the axis A), e.g., to allow fluid flow into and/or out from the optical fluid chamber 224 (FIG. 2D) even when the stiffening ring 270 is positioned at least partially therewithin.
  • FIG. 2F is a perspective view of the second component 208 of the AIOL 200.
  • the AIOL 200 can further include a stiffening ring 280 configured to be coupled to, over-molded into, and/or otherwise joined with the second component 208, such as the second optical portion 240 of the second component 208.
  • the stiffening ring 280 can be at least generally similar or identical in structure and/or function to the stiffening ring 270 (FIG. 2E).
  • the stiffening ring 280 can be configured to be coupled to an anterior or posterior side of the second component 208 and/or can be annularly shaped so as to define a central opening 282 configured to be aligned with an inner region of the second optical portion 240.
  • FIGS. 3A-3C are perspective, top, and side views, respectively, of another base 302 of an AIOL configured in accordance with embodiments of the present technology.
  • the base 302 can include a number of elements that are at least generally similar or identical in structure and/or function to elements of any of the bases described with reference to FIGS. 1A-2D.
  • the base 302 can include a first or anterior component 306, a second or posterior component 308, and one or more tabs 342, individual ones of which can be at least generally similar or identical in structure and/or function to the correspondingly named and/or numbered element in any of FIGS. 1 A-2D.
  • each of the tabs 342 can include an outer contact portion 344 and a connector portion 346.
  • the tabs 342 include (e.g., only include) a first or anterior portion 348 operably coupled to the first component 306, e.g., and do not include a second or posterior portion coupled to the second component 308.
  • the connector portion 346 does not have a reduced size relative to the outer contact portion 344, e.g., the connector portion 346 and the outer contact portion 344 together have a rectangular shape.
  • FIGS. 4A-4C are perspective, top, and side views, respectively, of another base 402 of an AIOL configured in accordance with embodiments of the present technology.
  • the base 402 can include some elements that are at least generally similar or identical in structure and/or function to elements of any one of the bases described with reference to FIGS. 1A- 3C.
  • the base 402 can include a first or anterior component 406, a second or posterior component 408, and one or more tabs 442, individual ones of which can be at least generally similar or identical in structure and/or function to the correspondingly named and/or numbered element in any of FIGS.
  • each of the tabs 442 can include an outer contact portion 444 and a connector portion 446 operably coupled to the first component 406, e.g., as described previously with reference to FIGS. 3A-3C.
  • the outer contact portions 444 of the tabs 442 have an increased size, e.g., to extend anteriorly from/relative to the connector portion 446. Increasing the size of the outer contact portions 444 is expected to increase or maximize contact area between the tabs 442 and the capsular bag of a patient’s eye.
  • FIGS. 5A-5C are perspective, top, and side views, respectively, of another base 502 of an AIOL configured in accordance with embodiments of the present technology.
  • the base 502 can include a number of elements that are at least generally similar or identical in structure and/or function to elements of any one of the bases described above with reference to FIGS. 1 A-4C.
  • the base 502 can include a first or anterior component 506, a second or posterior component 508, and one or more tabs 542, individual ones of which can be at least generally similar or identical in structure and/or function to the correspondingly named and/or numbered element in any of FIGS. 1 A-4C.
  • each of the tabs 542 can include an outer contact portion 544 and a connector portion 546 operably coupled to the first component 506, e.g., as described previously with reference to FIGS. 3A-4C.
  • the outer contact portions 544 of the tabs 542 can extend anteriorly from/relative to the connector portion 546, e.g., as described previously with reference to the outer contact portions 444 of the tabs 442 of FIGS. 4A-4C. Additionally, or alternatively, the outer contact portions 544 can extend laterally from/relative to the connector portion 546, e.g., to at least partially about/around an optical axis A of the base 502. Increasing the size of the outer contact portions 544 is expected to increase or maximize contact area between the tabs 542 and the capsular bag of a patient’ s eye.
  • FIG. 6A is a side cross-sectional view of another base 602 of an AIOL configured in accordance with embodiments of the present technology.
  • the base 602 can include a number of elements that are at least generally similar or identical in structure and/or function to elements of any one of the bases described above with reference to FIGS. 1 A-5C.
  • the base 602 can include a first or anterior component 606, a second or posterior component 608, and/or one or more tabs 642.
  • the base 602 defines a first fluid chamber or reservoir 622, a second fluid chamber or reservoir 624, and/or a channel 626, individual ones of which can be at least generally similar or identical in structure and/or function to the correspondingly named and/or numbered element in any of FIGS.
  • Each of the tabs 642 can include an outer contact portion 644 and a connector portion 646, e.g., as described previously with reference to FIGS. 2A-5C. However, compared to the tabs illustrated in FIGS. 2A-5C, each of the tabs 642 can define a hollow interior portion or chamber 664 (“tab chamber 664”).
  • Each of the tab chambers 664 can include a reservoir portion 666 and a passageway portion 668 positioned radially inward from the outer contact portion 644 and fluidly connecting the reservoir portion 666 to the outer fluid reservoir 622.
  • the reservoir portion 666 can be contained at least partially within and/or at least partially defined by the outer contact portion 644.
  • the passageway portion 668 can be contained at least partially within and/or at least partially defined by the connector portion 646.
  • FIG. 6B is an enlarged view of the tab 642 and outer fluid reservoir 622 of FIG. 6A.
  • forces from the patient’s eye e.g., in the radially inward direction D2 can deform the tabs 642 (e.g., in the radially inward direction D2) and produce a corresponding deformation of the tab chamber 664 and/or the outer fluid reservoir 622 (shown using dashed- lines in FIG. 6B).
  • deforming the tabs 642 radially inward can decrease a volume of at least the reservoir portion 666 of the tab chamber 664, thereby driving fluid from the reservoir portion 666 toward, into, and/or through the passageway portion 668.
  • Fluid within the passageway portion 668 can, in turn, move toward, into, and/or through the outer fluid reservoir 622.
  • the deformation of the outer fluid reservoir 622 can drive fluid toward and/or into the inner fluid reservoir 624 (FIG. 6A) to produce an accommodative response.
  • the added fluid from the tab chambers 664 is expected to increase the accommodative response, for example, by increasing the volume of fluid displaced into the inner fluid reservoir 624 (FIG.
  • the tab chambers 664 are expected to provide increased and/or more consistent accommodative responses for individuals with weaker ciliary muscles (e.g., due to aging, disease, genetics, etc.). In these and/or other embodiments, the tab chambers 664 are expected to allow a single size of the base 602 to fit an increased range of capsular bag sizes. For example, even though a single sized base may be undersized or oversized for a given patient, it is believed, without being bound by theory, that both undersized and oversized bases possess certain advantages. In some embodiments, for example, an undersized base is expected to provide greater change of accommodating sufficiently as capsule bag shrinks around it to apply tension/force. In some embodiments, an oversized base is expected to have increased potential to reduce size in response to constraint of capsular bag which, in turn, can bias the base 602 and/or the optical power provided thereby toward the dis -accommodative state.
  • FIG. 7A is a perspective cross-sectional view of an AIOL 700 configured in accordance with embodiments of the present technology. At least some aspects of the AIOL 700 can be at least generally similar or identical in structure and/or function to one or more of the AIOLs described herein.
  • the AIOL 700 can include a base 702 and the base 702 can include or define a first or anterior component 706; a second or posterior component 708; one or more grooves, slots, and/or other fixed lens receiving feature 712; a first or outer fluid chamber 722; a second or inner fluid chamber 724; and a channel 726; each of which can be at least generally similar or identical in structure and/or function to the correspondingly named and/or numbered structure in one or more of FIGS. 1A-6B.
  • the first and second components 706, 708 can be coupled to together, e.g., using adhesive.
  • the slots 712 in the base 702 can allow the base 702 to receive a fixed lens (e.g., the fixed lens 104 of FIG. 1 A) while the base 702 is positioned within a capsular bag of a patient’s eye.
  • the outer fluid chamber 722 can be defined at least partially between a first or outer wall 728 and a second or inner wall 730 of the first component 706 and/or a first or outer wall 732 and a second or inner wall 734 of the second component 708.
  • the inner and outer walls 728, 730, 732, 734 of the first and second components 706, 708 can define respective widths (e.g., radial width, inner widths, and/or a combination thereof) of the outer fluid chamber 722.
  • the inner and outer walls 728, 730 of the first component 706 define a first inner width W1 of the outer fluid chamber 722 (e.g., an upper and/or anterior portion of the outer fluid chamber 722) and the inner and outer walls 732, 734 of the second component 708 define a second inner width W2 of the outer fluid chamber 722 (e.g., a lower and/or posterior portion of the outer fluid chamber 722).
  • first inner width W1 is less than the second inner width W2, although in other embodiments the first inner width W 1 can be equal to or greater than the second inner width W2.
  • the inner fluid chamber 724 can be defined between a first optical portion 738 of the first component 706 and a second optical portion 740 of the second component 708.
  • the first and/or second optical portions 738, 740 can define a shape of the inner fluid reservoir 724 and the fluid within the inner fluid reservoir 724 can conform to that shape to provide an adjustable optical power, such that the inner fluid reservoir 724 (and, e.g., the fluid contained therein), the first optical portion 738, and the second optical portion 740 define an adjustable lens 736 of the base 702.
  • the channel 726 can extend between and fluidly couple the outer fluid reservoir 722 and the inner fluid reservoir 724 to allow the fluid to flow between the outer fluid reservoir 722 and the inner fluid reservoir 724, e.g., as the base 702 reacts one or more forces from the patient’s eye.
  • the base 702 further includes one or more folds or gaps 790 (individually identified as a first gap 790a and a second gap 790b) between the outer fluid chamber 722 and one or more other portions of the base 702.
  • first gap 790a is positioned between (e.g., radially between) the inner wall 730 and one or more of the slots 712
  • second gap 790b is positioned between (e.g., radially between) the inner wall 734 and at least a portion of the channel 726.
  • the first gap 790a can define a first distance G1 (e.g., a first radial distance or width, a first radial separation, and/or a combination thereof) and the second gap 790b can define a second distance G2 (e.g., a second radial distance or width, a second radial separation, and/or a combinations thereof).
  • the first distance G1 is less than the second distance G2, although in other embodiments the first distance G1 can be equal to or greater than the second distance G2.
  • the gaps 790 can define spaces and into which one or more of the walls 728, 730, 732, 734 of the outer fluid chamber 722 can be bent/flexed when the base 702 reacts one or more forces from the patient’s eye.
  • the base of the inner wall 730 can define a pivot point about which other (e.g., anterior) portions of the inner wall 730 can pivot (e.g., radially inwardly) into the space created by the first gap 790a in response to one or more forces from the patient’s eye.
  • the base 702 is expected to have an improved accommodative response in response to a given force or change in force from the patient’ s eye at least because the gaps 790 can allow for increased bending/flexing of the outer fluid chamber 722 and, as a result, provide increased fluid transfer between the outer fluid chamber 722 and the inner fluid chamber 724.
  • the gaps 790 can reduce the resistance to changes in the shape and/or volume of the outer fluid chamber 722, such that, in response to a given force or change in force on the base 702 from the patient’s eye, the shape and/or volume of the outer fluid chamber 722 is expected to change (e.g., increase or decrease) by a greater amount compared to an IOL that does not include one or more of the gaps 790.
  • changes in the shape and/or volume of the outer fluid chamber 722 are expected to produce corresponding changes in the optical power of the adjustable lens 736 (by, e.g., changing the shape and/or volume of the inner fluid chamber 724) and, accordingly, improving the ability of the outer fluid chamber 722 to change its shape and/or volume is expect to improve the accommodative response of the adjustable lens 736.
  • FIG. 7B is a side cross-sectional view of select portions of the base 702, with other portions omitted for the purpose of clarity.
  • the base 702 includes one or more castles 707 (individually identified as one or more first or anterior castles 707a and one or more second or posterior castles 707b).
  • the castles 707 can be at least generally similar or identical in structure and/or function to the castles 207 described previously with reference to at least FIG. 2E.
  • each of the castles 707 can be configured to space the first optical portion 738 apart from the second optical portion 740 7 when the first component 706 is coupled to the second component 708 so as to at least partially define the optical fluid chamber 724.
  • the one or more first castles 707a are coupled to and extend posteriorly outward from a posterior surface of the first component 706 and the one or more second castles 707b are coupled to and extend anteriorly outward from an anterior surface of the second component 708 such that, when the first and second components 706, 708 are coupled together, each of the first castles 707a can contact a corresponding one of the second castles 707b, such as shown in FIG. 7B.
  • adhesive can be applied to one or more of the first and/or second castles 707 a, b to facilitate coupling the first and second components 706, 708 to one another.
  • the base includes one or more thinned or narrowed regions 792 (individually identified as a first narrowed region 792a and a second narrowed region 792b) extend around all, or at least a portion, of a circumference/outer perimeter of the inner fluid chamber 724.
  • first narrowed region 792a extends around all or at least a portion of the first optical portion 738 of the first component 706 and the second narrowed region 792b extends around all or at least a portion of the second optical portion 740 of the second component 708.
  • the inner and/or outer boundaries of the narrowed regions 792 can be curved, tapered, or include one or more edges.
  • a radially -inner boundary 793 of the second narrowed region 792b is curved upwardly /anteriorly to at least partially define an inner/anterior surface of the second optical portion 740.
  • Each of the narrowed region 792 can define a hinge in the optical portions 738, 740 configured to improve the accommodative response and/or one or more other optical properties of the adjustable lens 736.
  • the narrowed regions 792 can have less resistance to bending/flexing than the optical portions 738, 740 and, accordingly, can reduce the bending/flexing resistance of the optical portions 738, 740. Accordingly, in response to a given force on the base 702 from the patient’s eye, the resulting bending/flexing of the optical portions 738, 740 is expected to produce a greater change in the shape and/or volume of the inner fluid chamber 724 and/or otherwise produce a greater change in the optical power provided by the adjustable lens 726.
  • Each of the narrowed regions 792 can be configured to dampen, or even prevent, force and/or load transfer from a peripheral or outer portion 794 (FIG. 7B) of the base 702 to the optical portions 738, 740.
  • forces from the eye on the base 702 can cause all or at least a portion of the peripheral portion 794 to bend or flex relative to an optical axis A defined by the adjustable lens 736.
  • bonding the first and second components 706, 708 at the castles 707 can introduce unwanted bending or strain into the base 702, e.g., if the bonds between the corresponding first and second castles 707a, b are not all planar or substantially planar.
  • These and/or other causes of bending/flexing/strain at or of the peripheral portion 794 of the base 702 can create one or more boundary conditions (e.g., compressive, tensile, torsional, and/or other forces and/or loads, and/or combinations thereof) on the peripheral portion 794 of the base 702 from the patient’s eye that may alter the modulation transfer function (MTF) and/or other optical properties of the adjustable lens 736 if those boundary conditions are imparted to the optical portions 738, 740.
  • boundary conditions e.g., compressive, tensile, torsional, and/or other forces and/or loads, and/or combinations thereof
  • the narrowed regions 792 have less resistance to bending/flexing than the optical portions 738, 740, and are positioned between the peripheral portion 794 and the optical portions 738, 740, the narrowed region 792 are, accordingly, expected to bend, flex, or otherwise react in response to one or more of the boundary conditions in the peripheral portion 794 to dampen, or prevent entirely, the one or more of the boundary conditions from being transferred to the optical portions 738, 740. This, in turn, is expected to maintain a more uniform force distribution across the optical portions 738, 740 of the AIOL 700 and/or otherwise improve the optical correction provided by the adjustable lens 736.
  • FIG. 7C is a bottom view of the first component 706 of the base 702.
  • the first component 706 can include a plurality of the first castles 707a (only one is labeled for simplicity) positioned circumferentially about the first optical portion 738 and the first narrowed region 792a.
  • the first component 706 include 18 first castles 707a.
  • the first component 706 can include more or fewer castles 707a, such as up to 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, or more castles.
  • Increasing the number of the first castles 707a is expected to improve (e.g., further improve) the optical properties of the base 702 by, e.g., reducing or prevent the formation of one or more of the boundary conditions described previously with reference to at least FIG. 7B.
  • each of the first castles 707a has a diameter that is less than a distance between adjacent ones of the castles 707a. In other embodiments, however, one or more of the first castles 707a can have larger or smaller diameters.
  • the first castles 707a are positioned to form a circle that is concentric with the first optical portion 738. In other embodiments, including those described below with reference to FIGS. 7E-7F, the first castles 707a can be positioned to form multiple circles, one or more of which can be concentric with the first optical portion 738.
  • the first castles 707a have a circular cross-sectional shape. In other embodiments, however, one or more of the first castles 707a can have an oval, triangular, square, rectangular, pentagonal, hexagonal, and/or one or more other cross-sectional shapes.
  • FIG. 7D is a top view of the second component 708 of the base 702.
  • the first component 708 can include a plurality of the second castles 707b (only one is labeled for simplicity) positioned circumferentially about the second optical portion 740 and the second narrowed region 792b.
  • the description of the first castles 707a with reference to FIG. 7C applies equally to the second castles 707b shown in FIG. 7D.
  • FIGS. 7E-7G illustrate alternate arrangements for the castles 707 shown in FIGS. 7A-7D.
  • FIG. 7E shows inner (e.g., radially inner) and outer (e.g. radially outer) rows of castles 707.
  • the inner and outer rows can define respective circles that share a center C, and the castles 707 in the inner and outer rows can be aligned with one another along one or more radii (shown in dashed line) extending from the center C.
  • FIGS. 7F and 7G also show inner (e.g., radially inner) and outer (e.g. radially outer) rows of castles 707 but, compared to FIG.
  • the castles 707 in the inner row are angularly offset from the castles 707 in the outer row.
  • the castles 707 in the inner row are tangent to a radius (one shown in dashed line) extending from the center C to the centers of the castles 707 in the outer row.
  • the castles 707 in the inner row do not intersect a radius (one shown in dashed line) extending from the center C to the centers of the castles (707).
  • the AIOL devices described herein may be implanted by preparing the eye and removing the native lens from the capsule in any appropriate manner.
  • the fluid-filled structure may then be placed in the capsule of the eye.
  • the patient may then be evaluated for a base optical power and/or astigmatic correction, and a fixed lens can be selected to provide the desired based power or astigmatic correction for the fluid-filled structure in the implanted state in the capsule of the eye.
  • the specific fixed lens to provide the post-implant base power or astigmatic correction is then inserted into the previously implanted fluid-filled structure of the AIOL.
  • the chosen fixed lens may then be coupled to the fluid-filled structure within the eye capsule.
  • the fixed lenses are anteriorly-positioned when implanted, e.g., positioned anterior to the adjustable lens and/or attached to the anterior first component of the AIOLs.
  • one or more of the fluid-filled accommodating structure or fixed lens may each be flexible such that they may be reconfigured (e.g., folded) to a reduced-profile delivery configuration for delivery into the lens capsule.
  • it may be required to make a further correction to the fixed portion after the time of the surgery. Such instance may occur anywhere from days to years after the surgery.
  • the patient may return to the physician and the fixed lens may be replaced with a new fixed lens having a different optical power or other prescription.
  • the new prescription may be characterized prior to or after removal of the original fixed lens.
  • the new fixed lens may be fabricated and implanted at the time of the examination, in others the patient may return for implantation of the fixed lens sometime after the examination.
  • kits having an accommodating structure and a first fixed lens that has no optical base power.
  • the kit can further include one or more second fixed lenses having various based powers or other optical properties.
  • the accommodating structure can be implanted into the native eye capsule, and then the first fixed lens can be coupled to the accommodating structure.
  • the optical properties of the implanted accommodating structure can then be assessed in situ with the first fixed lens in place to determine the desired optical properties of the fixed lens. If the optical properties of the assembled accommodating structure and first fixed lens without a base power are appropriate, then the system can remain implanted without additional changes.
  • the first fixed lens without a base power can be replaced with a second fixed lens having the desired optical properties based on the optical properties of the implanted accommodating portion with a fixed lens attached.
  • the fixed portion of the AIOL may be fabricated from materials different from the accommodating portion. Such materials include hydrophilic or hydrophobic methacrylate or silicones and any other materials traditionally used in nonaccommodating IOLS.
  • the fixed lens may be fabricated from materials harder than those used for the accommodating portion.
  • One or both of the accommodating portion/lens and the fixed portion/lens may be machined, cast molded (e.g., reactive cast molded), injected molded, and/or formed by other processes or combinations of processes.
  • Any or all of the structures described herein may be constructed from a transparent or translucent material.
  • the above-described accommodating structures and fixed lenses can be constructed from transparent materials, even if they are illustrated as opaque in the associated figures.
  • An accommodating intraocular lens for implantation within an eye of a patient, the AIOL comprising: a base defining an optical fluid chamber and an outer fluid reservoir positioned radially outwardly from the optical fluid chamber, wherein the base includes — an inner wall portion defining a radially inward surface of the outer fluid reservoir; a groove open toward an optical axis of the base; and a gap positioned radially between the inner wall portion and the groove; and a fixed lens configured to be releasably coupled to the base via the groove, wherein, when the fixed lens is coupled to the base, the fixed lens is positioned anterior to the optical fluid chamber and at least a portion of the fixed lens is received within the groove.
  • a base defining an optical fluid chamber and an outer fluid reservoir positioned radially outwardly from the optical fluid chamber, wherein the base includes — an inner wall portion defining a radially inward surface of the outer fluid reservoir; a groove open toward an optical axis of the base; and a gap positioned radially between
  • the base includes a first component and a second component and further defines a channel between the outer fluid reservoir and the optical fluid chamber
  • the inner wall portion is a first inner wall portion of the first component and is associated with an anterior portion of the outer fluid reservoir
  • the gap is a first gap
  • the second component includes a second inner wall portion associated with a posterior portion of the outer fluid reservoir and defines a second gap radially between the second inner wall portion and at least a portion of the channel.
  • the first gap has a first radial width and the second gap has a second radial width greater than the first radial width.
  • the base includes a first component and a second component
  • the first component includes a first optical portion that defines a first surface of the fluid optical chamber
  • the second component includes a second optical portion that defines a second surface of the fluid optical chamber
  • the first component and/or the second component further include a narrowed region extending at least circumferential around at least a portion of the first optical portion and/or the second optical portion.
  • An accommodating intraocular lens (AIOL) for implantation within an eye of a patient comprising: a base defining an optical fluid chamber and an outer fluid reservoir positioned radially outwardly from the optical fluid chamber, wherein the base includes- an outer wall portion positioned radially outwardly from the outer fluid reservoir; and a plurality of tabs operably coupled to the outer wall portion; and a lens configured to be removably coupled to the base, wherein, when the lens is coupled to the base, the lens is positioned anterior to the optical fluid chamber, wherein, when implanted within a capsular bag of the eye, the plurality of tabs are configured to deform the capsular bag from an accommodated state.
  • AIOL intraocular lens
  • the base includes a first component and a second component; the plurality of tabs include a first tab portion and a second tab portion; the first tab portion is coupled to the first component; and the second tab portion is coupled the second component.
  • An accommodating intraocular lens (AIOL) for implantation within an eye of a patient comprising: a base including — a first optical portion; a second optical portion spaced apart from the first optical portion along an optical axis; an outer wall portion having a center of curvature offset from the optical axis; and a tab operably coupled to the outer wall portion, wherein the tab is configured to contact tissue of the eye when the AIOL is implanted within the eye of the patient; and a lens configured to be removably coupled to the base, wherein, when the lens is coupled to the base, the lens is positioned anterior to the first optical portion and the second optical portion along the optical axis.
  • AIOL intraocular lens
  • the outer wall portion has a height and includes a central region and one or more comer regions; individual ones of the one or more comer regions are positioned anteriorly or posteriorly of the central region, and the one or more corner regions account for less than 40%, 30%, 20%, 10%, or 5% of the height of the outer wall portion.
  • An accommodating intraocular lens for implantation within an eye of a patient, the AIOL comprising: a base including — a first optical portion having a first inner region and a first peripheral region positioned radially outwardly from the first inner region; a second optical portion spaced apart from the first optical portion along an optical axis, the second optical portion having a second inner region and a second peripheral region positioned radially outwardly from the second inner region; and a stiffening ring configured to be coupled to the first peripheral region or the second peripheral region to at least partially prevent the first peripheral region or the second peripheral region from deforming when the base reacts a force from the eye; a lens configured to be removably coupled to the base, wherein, when the lens is coupled to the base, the lens is positioned anterior to the first optical portion and the second optical portion along the optical axis.
  • a base including — a first optical portion having a first inner region and a first peripheral region positioned radially outwardly from the first inner region; a second optical
  • the base further includes an anterior component and a posterior component
  • the anterior component includes the first optical portion and the posterior component includes the second optical portion
  • the anterior component further includes a posterior surface facing toward the posterior component and a castle projecting posteriorly from the posterior surface to contact the posterior component to space the first optical portion apart from the second optical portion
  • the stiffening ring is configured to be coupled to the posterior surface and includes a notch configured to receive the castle when the stiffening ring is coupled to the posterior surface.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Prostheses (AREA)

Abstract

La présente technologie concerne des bases pour des lentilles intraoculaires de réception à composants multiples et des procédés associés de fabrication et d'utilisation de tels dispositifs. Dans de nombreux modes de réalisation divulgués ici, les AIOL comprennent une base qui délimite une lentille de puissance de réception ou réglable et est configurée pour recevoir une autre lentille présentant une puissance optique fixe. La lentille de réception peut comprendre une chambre de fluide optique délimitée par la base et configurée pour changer la forme et/ou le volume, par exemple, en réponse à des forces provenant de l'œil du patient. La base peut être implantée à l'intérieur d'un sac capsulaire de l'œil du patient et configurée pour faire réagir une ou plusieurs forces provenant du sac capsulaire pour régler ou modifier la puissance optique de la lentille de réception. Dans au moins certains modes de réalisation, les bases de la présente technologie sont censées avoir une réponse améliorée et/ou maximisée à des forces provenant de l'œil.
PCT/US2024/052058 2023-10-20 2024-10-18 Bases pour lentilles intraoculaires de réception à composants multiples et procédés associés Pending WO2025085806A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363592065P 2023-10-20 2023-10-20
US63/592,065 2023-10-20

Publications (1)

Publication Number Publication Date
WO2025085806A1 true WO2025085806A1 (fr) 2025-04-24

Family

ID=95449302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/052058 Pending WO2025085806A1 (fr) 2023-10-20 2024-10-18 Bases pour lentilles intraoculaires de réception à composants multiples et procédés associés

Country Status (1)

Country Link
WO (1) WO2025085806A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180177589A1 (en) * 2016-12-23 2018-06-28 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
US20190159890A1 (en) * 2014-08-26 2019-05-30 Shifamed Holdings, Llc Accommodating intraocular lens
US20200146813A1 (en) * 2017-06-07 2020-05-14 Shifamed Holdings, Llc Adjustable optical power intraocular lenses
US20220273423A1 (en) * 2015-11-18 2022-09-01 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
WO2022226269A1 (fr) * 2021-04-22 2022-10-27 Shifamed Holdings, Llc Lentilles intraoculaires adaptatives et procédés associés

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190159890A1 (en) * 2014-08-26 2019-05-30 Shifamed Holdings, Llc Accommodating intraocular lens
US20220273423A1 (en) * 2015-11-18 2022-09-01 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
US20180177589A1 (en) * 2016-12-23 2018-06-28 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
US20200146813A1 (en) * 2017-06-07 2020-05-14 Shifamed Holdings, Llc Adjustable optical power intraocular lenses
WO2022226269A1 (fr) * 2021-04-22 2022-10-27 Shifamed Holdings, Llc Lentilles intraoculaires adaptatives et procédés associés

Similar Documents

Publication Publication Date Title
US10390937B2 (en) Accommodating intraocular lenses
EP1965734B1 (fr) Lentille intraoculaire d'accommodation dotee d'une structure exterieure de support
EP2493421B1 (fr) Conception diffractive à distance centrale et à déphasage pour implant oculaire
EP0662808B1 (fr) Systeme de lentilles intraoculaires
US5366502A (en) Supplementary intraocular lens system
RU2651088C2 (ru) Аккомодационная интраокулярная линза с изменяемой кривизной
EP2295009B1 (fr) Implant de lentille intraoculaire
JP4624967B2 (ja) 眼内レンズ系
CN114667115B (zh) 具有复曲面的可调节人工晶状体
KR20040105813A (ko) 직조된 햅틱부를 갖는 조절기능성 안내 렌즈
CN106535823A (zh) 调节眼内晶状体装置
CA2787997A1 (fr) Lentille intraoculaire monofocale a zones multiples pour la correction d'aberrations optiques
WO2003059208A2 (fr) Accommodation d'une lentille intraoculaire a anneau de sac capsulaire integral
US20230063391A1 (en) Accommodating intraocular lenses and associated methods
AU2024200996B2 (en) Intraocular lenses with shape-changing optics and stabilizing properties
EP4654921A2 (fr) Lentilles intraoculaires accommodatives et ensembles et méthodes associés
WO2025085806A1 (fr) Bases pour lentilles intraoculaires de réception à composants multiples et procédés associés
RU2828225C2 (ru) Офтальмологическая линза с увеличенной глубиной фокуса
US20220296363A1 (en) Accommodative Intraocular Lens Combination with Independent Fixed and Variable Power Lens Sections
HK40069186A (en) Accommodating intraocular lens device
HK40014397A (en) Accommodating intraocular lens device
HK1235658A1 (en) Accommodating intraocular lens device

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24880688

Country of ref document: EP

Kind code of ref document: A1