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WO2025085109A3 - Procédés de prévention d'arthrose post-traumatique à l'aide de metformine - Google Patents

Procédés de prévention d'arthrose post-traumatique à l'aide de metformine Download PDF

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Publication number
WO2025085109A3
WO2025085109A3 PCT/US2024/028754 US2024028754W WO2025085109A3 WO 2025085109 A3 WO2025085109 A3 WO 2025085109A3 US 2024028754 W US2024028754 W US 2024028754W WO 2025085109 A3 WO2025085109 A3 WO 2025085109A3
Authority
WO
WIPO (PCT)
Prior art keywords
metformin
methods
osteoarthritis
traumatic osteoarthritis
post
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/028754
Other languages
English (en)
Other versions
WO2025085109A2 (fr
Inventor
Diane Renee WAGNER
Todd Owen MCKINLEY
Roman Michael NATOLI
Uma SANKAR-DAVIS
Sonali J. KARNIK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University
Indiana University Bloomington
Original Assignee
Indiana University
Indiana University Bloomington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University, Indiana University Bloomington filed Critical Indiana University
Publication of WO2025085109A2 publication Critical patent/WO2025085109A2/fr
Publication of WO2025085109A3 publication Critical patent/WO2025085109A3/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des procédés d'utilisation de metformine ou d'un sel pharmaceutiquement acceptable de celle-ci, tels qu'une administration intra-articulaire de metformine, pour traiter des articulations endommagées. L'invention concerne également des procédés d'utilisation de metformine pour empêcher la progression de l'arthrose, telle qu'une arthrose résultant d'une lésion, ou une arthrose post-traumatique. L'invention concerne en outre des schémas posologiques et des compositions de metformine pour le traitement et la prévention d'arthrose post-traumatique.
PCT/US2024/028754 2023-05-11 2024-05-10 Procédés de prévention d'arthrose post-traumatique à l'aide de metformine Pending WO2025085109A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363465651P 2023-05-11 2023-05-11
US63/465,651 2023-05-11

Publications (2)

Publication Number Publication Date
WO2025085109A2 WO2025085109A2 (fr) 2025-04-24
WO2025085109A3 true WO2025085109A3 (fr) 2025-06-05

Family

ID=95448957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/028754 Pending WO2025085109A2 (fr) 2023-05-11 2024-05-10 Procédés de prévention d'arthrose post-traumatique à l'aide de metformine

Country Status (1)

Country Link
WO (1) WO2025085109A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130324463A1 (en) * 2012-05-24 2013-12-05 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor for modifying food intake and regulating food preference
US20140186306A1 (en) * 2012-09-28 2014-07-03 Paul Ronald Plante Novel ampk agonist compositions and methods of use
US20210085827A1 (en) * 2015-08-19 2021-03-25 University Of Iowa Research Foundation Preventative therapy for post-traumatic osteoarthritis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130324463A1 (en) * 2012-05-24 2013-12-05 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor for modifying food intake and regulating food preference
US20140186306A1 (en) * 2012-09-28 2014-07-03 Paul Ronald Plante Novel ampk agonist compositions and methods of use
US20210085827A1 (en) * 2015-08-19 2021-03-25 University Of Iowa Research Foundation Preventative therapy for post-traumatic osteoarthritis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LIM ET AL.: "Metformin as a potential disease-modifying drug in osteoarthritis: a systematic review of pre-clinical and human studies", OSTEOARTHRITIS AND CARTILAGE, vol. 30, 2022, pages 1434 - 1442, XP087009859, DOI: 10.1016/j.joca.2022.02.596 *
MODI JUHI: "Metformin vs Metformin Hydrochloride: Similarities & Differences", BUZZRX, 11 December 2023 (2023-12-11), XP093333954, Retrieved from the Internet <URL:https://www.buzzrx.com/blog/metformin-vs-metformin-hydrochloride-similarities-differences> *
WANG YIFEI, SONG WEI, LI YIMING, ZHOU ZHEKUN, LI CHENKAI, YU WEILIN, HE YAOHUA: "Metformin-loaded PLGA microspheres combined with an in situ-formed injectable SA/BG hydrogel alleviate rotator cuff muscle degeneration", MATERIALS TODAY BIO, ELSEVIER, vol. 23, 1 December 2023 (2023-12-01), pages 100874, XP093333957, ISSN: 2590-0064, DOI: 10.1016/j.mtbio.2023.100874 *

Also Published As

Publication number Publication date
WO2025085109A2 (fr) 2025-04-24

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