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WO2025084693A1 - Dispositif de diagnostic de tumeur pancréatique - Google Patents

Dispositif de diagnostic de tumeur pancréatique Download PDF

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Publication number
WO2025084693A1
WO2025084693A1 PCT/KR2024/015260 KR2024015260W WO2025084693A1 WO 2025084693 A1 WO2025084693 A1 WO 2025084693A1 KR 2024015260 W KR2024015260 W KR 2024015260W WO 2025084693 A1 WO2025084693 A1 WO 2025084693A1
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WIPO (PCT)
Prior art keywords
endoscope cap
pancreatic tumor
insertion tube
pancreatic
diagnostic device
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Pending
Application number
PCT/KR2024/015260
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English (en)
Korean (ko)
Inventor
박도현
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Asan Foundation
University of Ulsan Foundation for Industry Cooperation
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Asan Foundation
University of Ulsan Foundation for Industry Cooperation
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Publication of WO2025084693A1 publication Critical patent/WO2025084693A1/fr
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
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    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
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    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00097—Sensors
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    • A61B1/00131—Accessories for endoscopes
    • A61B1/00137—End pieces at either end of the endoscope, e.g. caps, seals or forceps plugs
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    • A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
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    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
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    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
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    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
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    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
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    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters
    • A—HUMAN NECESSITIES
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    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions

Definitions

  • the present invention relates to a pancreatic tumor diagnostic device, and more particularly, to a pancreatic tumor diagnostic device that can be easily fixed to the duodenal mucosa and enables the early diagnosis of pancreatic cancer quickly and accurately.
  • Pancreatic cancer is the fourth leading cause of cancer deaths in the United States, and is a fatal disease with a 1-year mortality rate of 74% and a 5-year mortality rate of 94%. In fact, surgical resection is only possible for about 20% of pancreatic cancer patients, and only about 20% of these patients can expect a 5-year survival rate.
  • pancreatic cancer Therefore, early diagnosis of pancreatic cancer is very important.
  • pancreatic cancer has no symptoms in the early stages and symptoms appear after the disease has progressed considerably, making early diagnosis of pancreatic cancer difficult.
  • pancreatic cancer Various technologies, including various blood biomarkers and screening methods, are being developed for the early diagnosis of pancreatic cancer, but the actual early diagnosis rate of pancreatic cancer is still minimal.
  • EIBS early increase in blood supply
  • DHb deoxyhemoglobin concentration
  • BVR blood vessel radius
  • pancreatic tumor diagnostic device that can be easily fixed to the examination site, such as the duodenal mucosa, and can accurately and quickly measure various indicators.
  • the present invention aims to provide a pancreatic tumor diagnosis device that can be easily fixed to a diagnostic site.
  • the present invention aims to provide a pancreatic tumor diagnostic device capable of accurately and quickly diagnosing a tumor at an early stage.
  • one aspect of the present invention may include an insertion tube formed to be extended to be inserted into a patient's body and including a distal portion and a proximal portion, an endoscope cap formed to be extended to have a length and arranged to surround an outer circumferential surface of the insertion tube and arranged at a position spaced apart from the distal portion of the insertion tube by a predetermined distance, and a plurality of LED sensors arranged on a surface of the endoscope cap.
  • the present invention can provide a pancreatic tumor diagnosis device capable of accurately and quickly diagnosing a tumor at an early stage.
  • the present invention can provide a pancreatic tumor diagnosis device that can be easily fixed to a diagnosis site.
  • FIG. 1 is a schematic diagram illustrating a pancreatic tumor diagnosis device according to one embodiment of the present invention.
  • Figure 2 is a drawing illustrating the insertion tube of Figure 1.
  • Figure 3 is a drawing illustrating the endoscope cap of Figure 1.
  • Fig. 4 is a modified example of the endoscope cap of Fig. 3.
  • Figure 5 is a drawing for explaining how the endoscope cap irradiates light.
  • FIG. 6 is a drawing for explaining an example of a pancreatic tumor diagnosis device according to the present invention being inserted into a patient's body and operated.
  • FIG. 7 is a drawing for explaining one embodiment of the internal structure of the endoscope cap of FIG. 1.
  • one aspect of the present invention may include an insertion tube formed to be extended to be inserted into a patient's body and including a distal portion and a proximal portion, an endoscope cap formed to be extended to have a length and arranged to surround an outer circumferential surface of the insertion tube and arranged at a position spaced apart from the distal portion of the insertion tube by a predetermined distance, and a plurality of LED sensors arranged on a surface of the endoscope cap.
  • the insertion tube may include a linear portion extending linearly from the distal portion, a curved portion extending from the linear portion and formed to be bendable, and an extension portion extending proximally from the curved portion, and the endoscope cap may be arranged to surround at least a portion of the curved portion.
  • the endoscope cap may be formed of a transparent material.
  • the endoscope cap may be formed of an elastic material.
  • the LED sensor can irradiate light of different wavelengths.
  • the LED sensor can irradiate light in a wavelength range between 600 and 900 nm and a near-infrared wavelength range.
  • the endoscope cap may include a port communicating with the outside through which pancreatic fluid and duodenal fluid flow.
  • the device may further include a position sensor for detecting the position of the duodenum within the patient's body.
  • the device may further include a pH sensor for detecting the type of duodenal fluid in the patient's body.
  • first, second, etc. are not used in a limiting sense but are used for the purpose of distinguishing one component from another.
  • the x-axis, y-axis, and z-axis are not limited to three axes on an orthogonal coordinate system, and can be interpreted in a broad sense that includes them.
  • the x-axis, y-axis, and z-axis may be orthogonal to each other, but may also refer to different directions that are not orthogonal to each other.
  • a particular process sequence may be performed in a different order than the one described.
  • two processes described in succession may be performed substantially simultaneously, or in a reverse order from the one described.
  • pancreatic tumor diagnosis device based on the above-described principles will be described in detail with reference to the drawings.
  • FIG. 1 is a drawing schematically illustrating a pancreatic tumor diagnosis device according to one embodiment of the present invention
  • FIG. 2 is a drawing illustrating an insertion tube (100) of FIG. 1
  • FIG. 3 is a drawing illustrating an endoscope cap (200) of FIG. 1.
  • a pancreatic tumor diagnosis device may include an insertion tube (100) and an endoscope cap (200).
  • the insertion tube (100) can be connected to an external device and formed to extend so as to be inserted into a patient's body.
  • the insertion tube (100) can be connected to an external device and supplied with power.
  • the insertion tube (100) can be connected to an external device and inserted deep into a patient's body and can change direction during the insertion process.
  • the insertion tube (100) may include a lighting unit that irradiates light inside the patient's body, a camera unit that photographs the inside of the patient's body, a nozzle unit that sprays water or gas, etc.
  • the insertion tube (100) may include an air insufflation unit for spreading out the mucosal folds of the patient's organ through air insufflation inside the patient's body.
  • an air insufflation unit for spreading out the mucosal folds of the patient's organ through air insufflation inside the patient's body.
  • the folds of the duodenal mucosa may be spread through air insufflation.
  • the insertion tube (100) may include a distal portion (101) and a proximal portion (102).
  • the distal portion (101) may mean a portion that is distant from an external device.
  • the distal portion (101) may mean a terminal portion that is inserted into a patient's body.
  • the proximal portion (102) may mean a portion close to an external device.
  • the proximal portion (102) may mean a portion connected to an external device.
  • the insertion tube (100) may sequentially include a linear portion (110), a curved portion (120), and an extended portion (130) in a direction from the distal portion (101) to the proximal portion (102).
  • the linear portion (110) is a portion that extends linearly from the distal portion (101).
  • the linear portion (110) is formed in a straight line and may not be bent.
  • a lighting portion, a camera portion, a nozzle portion, etc. may be arranged in the linear portion (110). Therefore, the linear portion (110) is formed so as not to be bent, and the lighting portion, the camera portion, the nozzle portion, etc. may not be damaged.
  • the bent portion (120) is a portion extending from the linear portion (110).
  • the bent portion (120) may be formed to extend from the end of the linear portion (110) toward the proximal portion (102).
  • the bent portion (120) may be formed to be bendable. Accordingly, as the bent portion (120) bends inside the patient's body, the insertion tube (100) may be inserted deep into the patient's body while changing direction inside the patient's body.
  • the extension portion (130) is a portion that extends from the bend portion (120).
  • the extension portion (130) can be formed to extend from the end of the bend portion (120) toward the proximal portion (102).
  • the extension portion (130) can play a role in connecting the linear portion (110) and the bend portion (120) to an external device. Accordingly, power or an electric signal, etc. can be transmitted from the external device to the linear portion (110) and the bend portion (120).
  • the endoscope cap (200) is formed to be extended to have a length and can be positioned to surround the outer surface of the insertion tube (100).
  • the endoscope cap (200) may be formed to be extended to have a length (L) of 5 to 15 cm. Accordingly, the endoscope cap (200) is placed inside the patient's duodenum, thereby having the effect of allowing a wide portion of the duodenum to be observed simultaneously.
  • the endoscope cap (200) may include a body (210).
  • the body (210) may form the overall outer shape of the endoscope cap (200).
  • a hollow (220) may be formed in the body (210) of the endoscope cap (200).
  • the hollow (220) may be formed to penetrate the central portion of the body (210) along the longitudinal direction of the endoscope cap (200).
  • the endoscope cap (200) may be formed in the shape of a cylinder or cylindrical shape having a hole formed along the longitudinal direction therein. Accordingly, an insertion tube (100) may be inserted into the hollow (220) of the endoscope cap (200).
  • the diameter of the hollow portion (220) of the endoscope cap (200) may be formed to be the same as the outer diameter of the insertion tube (100). Accordingly, the insertion tube (100) can be firmly fixed after being inserted into the hollow portion (220) of the endoscope cap (200).
  • the diameter of the hollow portion (220) of the endoscope cap (200) may be formed to be larger than the outer diameter of the insertion tube (100), and in this case, a fastening member may be further formed on the endoscope cap (200) to be fixed to the insertion tube (100).
  • the endoscope cap (200) since the endoscope cap (200) according to the present invention is formed in a cylindrical or cylinder shape, it can implement 3D mapping using a single pixel and an array through a hybrid channel (single and multichannel) to increase the accuracy of the duodenal optical biomarker and perform the function of OCT (Optical Coherence Tomography). Therefore, as an optional embodiment, the pancreatic tumor diagnosis device according to the present invention can configure various pixel arrays in the endoscope cap (200) and further include an OCT detector or an OCT camera.
  • the endoscope cap (200) may be positioned at a predetermined distance from the distal end (101) of the insertion tube (100).
  • the endoscope cap (200) may be positioned at a distance of 5 cm to 8 cm from the end of the distal end (101) of the insertion tube (100).
  • the endoscope cap (200) may be positioned so as not to surround the curved portion (120) of the insertion tube (100), or may be positioned so as to surround at least a portion of it.
  • the endoscope cap (200) may be positioned across the curved portion (120) of the insertion tube (100), or may be positioned so as to surround a portion of the linear portion (110) and a portion of the curved portion (120).
  • the endoscope cap (200) can be bent together when the portion after the bend (120) of the insertion tube (100) is passively bent.
  • the endoscope cap (200) may be formed of an elastic material. Accordingly, the endoscope cap (200) may be bent by an external force. That is, when the portion after the bend (120) of the insertion tube (100) is passively bent, the endoscope cap (200) may be bent to correspond to the portion after the bend (120).
  • the endoscope cap (200) when the endoscope cap (200) reaches the patient's duodenum, the endoscope cap (200) can be bent to correspond to the shape of the duodenum. In addition, as described below, the endoscope cap (200) can observe the mucosa of the duodenum in more detail.
  • the pancreatic tumor diagnosis device can maintain the mobility of the endoscope by wrapping at least a part of the bending portion (120) of the insertion tube (endoscope) or arranging the endoscope cap (200) behind the bending portion (120).
  • the pancreatic tumor diagnosis device can observe and evaluate the entire range of the duodenum by placing an endoscope cap (200) composed of a flexible cap of 10 cm or more on a portion having passive flexibility of an insertion tube (endoscope), so that the flexible endoscope cap (200) can be appropriately moved to correspond to the passive flexibility of the insertion tube.
  • an endoscope cap composed of a flexible cap of 10 cm or more on a portion having passive flexibility of an insertion tube (endoscope)
  • the pancreatic tumor diagnosis device can also be used for endoscopic photobiomodulation and photodynamic/photothermal therapy.
  • the endoscope cap (200) may be formed of a transparent material. Accordingly, while the LED sensor (230) of the endoscope cap (200) measures the Early Increase in Blood Supply (EIBS) of the pancreas, a general endoscopic examination can be performed simultaneously through the insertion tube (100). For example, while the LED sensor (230) of the endoscope cap (200) measures the Early Increase in Blood Supply (EIBS) of the pancreas, the camera unit equipped in the insertion tube (100) can measure the mucosa of the duodenum or other parts.
  • EIBS Early Increase in Blood Supply
  • the camera unit equipped in the insertion tube (100) can measure the mucosa of the duodenum or other parts.
  • a pancreatic tumor diagnosis device may include a plurality of LED sensors (230) arranged on a surface of an endoscope cap (200).
  • the LED sensor (230) may include a plurality of light sources.
  • the light source may be an LED, an OLED, a micro LED, a mini LED, or as another example, the light source may be a flexible LED, or as yet another example, the light source may be a quantum dot LED.
  • the various examples of the light sources described above will be collectively referred to as LEDs, and it should be understood that the term “LED sensor (230)” collectively refers to a sensor including at least one of the various light sources described above.
  • the LED sensor (230) can perform a sensor function by including a part that irradiates light and a part that receives light.
  • the light source of the LED sensor (230) may be configured in a form capable of spectroscopy. Therefore, as an optional embodiment, the LED sensor (230) according to the present invention may further be equipped with a CCD camera in the endoscope cap (200) to perform the function of a spectrometer.
  • a plurality of LED sensors (230) may be arranged to form a plurality of rows and columns on the surface of the endoscope cap (200). Specifically, the LED sensors (230) may be arranged to cover the entire outer surface of the endoscope cap (200).
  • the LED sensor (230) may be composed of one or more pixels, and the pixels may be composed of an LED that irradiates light with a wavelength of 600-900 nm or near-infrared light and an organic photodiode that obtains information obtained from a tissue by the light irradiation.
  • These pixels may be arranged at positions 5 mm above and 1 cm below the major duodenal papilla and may measure the Deoxyhemoglobin Concentration (DHb) and the Blood Vessel Radius (BVR) of the duodenal mucosa.
  • the LED sensor (230) can obtain additional information from the opposite part of the above-mentioned area to improve the accuracy of information obtained from the major duodenal papilla.
  • the motion artifact motion artefact
  • the transmission part of the insertion tube is turned off, the duodenal mucosa comes into close contact with the endoscope cap (200), so that the sensing of various parts of the duodenum can be maximized.
  • the arrangement of these LEDs can be various, such as having an interval of 1 cm to 3 cm, and the accuracy of the examination can be increased and the sensing of the papilla can be made precise by using 3D mapping through the arrangement of LEDs using a surface light source such as OLED or a multi-channel and a cylindrical three-dimensional structure of the endoscope cap.
  • the LED sensor (230) when the LED sensor (230) is placed at a specific location in the patient's body, it can observe the entire direction facing the outer surface of the endoscope cap (200), for example, the entire inside of the duodenal mucosa.
  • the LED sensor (230) When the LED sensor (230) is positioned inside the duodenum, it can measure the DHb (Deoxyhemoglobin Concentration) and BVR (Blood Vessel Radius) of the duodenum. The specific measurement method of the LED sensor (230) will be described in detail later.
  • DHb Deoxyhemoglobin Concentration
  • BVR Blood Vessel Radius
  • Fig. 4 is a modified example (200') of the endoscope cap (200) of Fig. 3.
  • an endoscope cap (200') may be formed in the shape of a cylinder or cylindrical shape that can be opened and closed.
  • the endoscope cap (200') is formed to be extended to have a length, and can be formed in a shape that can wrap around the outer surface of the insertion tube (100).
  • the endoscope cap (200') may be formed to be extended to have a length (L) of 5 to 15 cm. Accordingly, the endoscope cap (200') is placed inside the patient's duodenum, and has the effect of allowing a wide portion of the duodenum to be observed simultaneously.
  • the endoscope cap (200') may include a body (210').
  • the body (210') may form the overall outer shape of the endoscope cap (200').
  • the body (210') may be formed to be openable and closable.
  • the body (210') may have a hinge formed along the longitudinal direction, and both sides may be rotatable based on the hinge.
  • a hollow (220') may be formed in the body (210') of the endoscope cap (200').
  • the hollow (220') may be formed to penetrate the central portion of the body (210') along the longitudinal direction of the endoscope cap (200').
  • the endoscope cap (200') may be formed in a shape in which the hollow (220') is formed along the longitudinal direction inside and a cylinder or cylindrical body is cut along the longitudinal direction and then opened. Accordingly, the endoscope cap (200') may be folded to surround the outer surface of the insertion tube (100) and may wrap the outer surface of the insertion tube (100).
  • the diameter of the hollow portion (220') of the endoscope cap (200') may be formed to be the same as the outer diameter of the insertion tube (100). Accordingly, the insertion tube (100) may be firmly fixed after being inserted into the hollow portion (220') of the endoscope cap (200').
  • the diameter of the hollow space (220') of the endoscope cap (200') may be formed larger than the outer diameter of the insertion tube (100), and in this case, a fastening member may be further formed on the endoscope cap (200') to be fixed to the insertion tube (100).
  • the endoscope cap (200') may further include a joining member for joining the cut portions of the bodies (210') on both sides after they are folded to form a cylindrical or cylindrical shape.
  • the joining member may be a magnetic member joined or attached to the bodies (210') on both sides of the body (210').
  • the joining member may be formed in the shape of a hook or a ring.
  • the joining member may be formed in the form of a groove with a protrusion formed in a forced-fit manner.
  • the present invention is not limited thereto, and any structure that can join the bodies (210') on both sides after the endoscope cap (200') is arranged to surround the outer surface of the insertion tube (100) may be adopted.
  • FIG. 5 is a drawing for explaining that the endoscope cap (200) irradiates light
  • FIG. 6 is a drawing for explaining an example of a pancreatic tumor diagnosis device according to the present invention being inserted into a patient's body and operated.
  • the LED sensor (230) according to the present invention can irradiate light.
  • a pancreatic tumor diagnosis device can be inserted into a patient's body to measure various indicators of the body.
  • the pancreatic tumor diagnosis device according to the present invention can measure various indicators of the patient's body while the endoscope cap (200) is inserted into the patient's duodenum.
  • the pancreatic tumor diagnosis device can measure DHb (Deoxyhemoglobin Concentration) and BVR (Blood Vessel Radius) in the duodenum through the LED sensor (230) arranged on the outside of the endoscope cap (200). This is to measure EIBS (Early Increase in Blood Supply) of the duodenum in the patient's duodenum.
  • EIBS Early Increase in Blood Supply
  • DHb Deoxyhemoglobin Concentration
  • BVR Blood Vessel Radius
  • the pancreatic tumor diagnosis device can measure the stiffness of blood vessels by recognizing the contraction/relaxation state of blood vessels.
  • the pancreatic tumor diagnosis device can measure the stiffness of blood vessels through an LED sensor (230) placed on the outside of the endoscope cap (200).
  • the pancreatic tumor diagnosis device can measure DHb (Deoxyhemoglobin Concentration) and BVR (Blood Vessel Radius) through the LED sensor (230) placed on the surface of the endoscope cap (200), and by measuring blood vessel stiffness, the user can diagnose the pancreatic tumor of the patient at an early stage.
  • DHb Deoxyhemoglobin Concentration
  • BVR Blood Vessel Radius
  • the pancreatic tumor diagnosis device may further include a position sensor, although not shown in the drawing.
  • the position sensor may sense the duodenal papilla inside the duodenum.
  • the position sensor may sense the major duodenal papilla corresponding to the pancreas head among the duodenal papilla.
  • the position sensor may be a sensor for measuring whether the mucosa protrudes inside the duodenum, and thereby senses the protruding mucosal structure, thereby sensing the duodenal papilla of the duodenum, and as a preferred example, the major duodenal papilla.
  • a medical metal hemoclip commonly used through an endoscope may be attached near the major duodenal papilla, and this clip may be used as a landmark for the position sensor of the endoscope cap (200) to identify the position of the major duodenal papilla.
  • the position of the endoscope cap (200) and the position of the major duodenal papilla to which the clip is attached may be identified using X-ray fluoroscopy equipment.
  • pancreatic tumor diagnosis device According to the present invention, it is possible to assign weights to various indicators according to their positions and improve the accuracy of diagnosis.
  • DHb deoxyhemoglobin concentration
  • BVR blood vessel radius
  • vascular stiffness increase around the major duodenal papilla
  • DHb deoxyhemoglobin concentration
  • BVR blood vessel radius
  • vascular stiffness increase far from the major duodenal papilla or in the opposite direction to the major duodenal papilla.
  • the pancreatic tumor diagnosis device can accurately sense the location of the major duodenal papilla through the location sensor and the camera unit placed in the insertion tube (100).
  • the endoscope cap (200) to the major papilla, the DHb (Deoxyhemoglobin Concentration), BVR (Blood Vessel Radius) and vascular stiffness according to each location of the duodenum can be measured, thereby improving the diagnostic accuracy of pancreatic tumors.
  • the user places the endoscope cap (200) close to or in contact with the major duodenal papilla of the duodenum, and then compares the DHb (Deoxyhemoglobin Concentration), BVR (Blood Vessel Radius) and vascular stiffness measured through the LED sensor (230) placed on the opposite side of the major duodenal papilla with the DHb (Deoxyhemoglobin Concentration), BVR (Blood Vessel Radius) and vascular stiffness measured through the LED sensor (230) placed around the major duodenal papilla, thereby enabling early diagnosis of pancreatic tumors.
  • DHb Deoxyhemoglobin Concentration
  • BVR Blood Vessel Radius
  • vascular stiffness measured through the LED sensor (230) placed around the major duodenal papilla thereby enabling early diagnosis of pancreatic tumors.
  • the LED sensor (230) can irradiate light having a wavelength of 500 to 1000 nm and light having a near-infrared wavelength, and preferably can irradiate light having a wavelength of 600 to 900 nm and light having a near-infrared wavelength.
  • the LED sensor (230) can irradiate light of different wavelengths. Assuming that the major duodenal papilla is arranged on the upper side of the endoscope cap (200) of FIG. 5, the LED sensor (230) arranged in a direction toward the major duodenal papilla can irradiate the first light (L1), and the LED sensor (230) arranged in a direction opposite to the major duodenal papilla can irradiate the second light (L2).
  • the first light (L1) may be light having a wavelength of 800 to 900 nm and a near-infrared wavelength.
  • the first light (L1) may be light having a wavelength of 850 nm.
  • the second light (L2) may be light having a wavelength of 680 to 780 nm.
  • the second light (L2) may be light having a wavelength of 630 nm.
  • the LED sensor (230) may each include a light source irradiating first light (L1) and a light source irradiating second light (L2).
  • the light source irradiating the first light (L1) may be positioned at a position oriented toward the duodenum when the endoscope cap (200) according to the present invention is positioned at the correct position by sensing the major duodenal papilla of the duodenum.
  • the light source irradiating the second light (L2) may be positioned at a position oriented toward the opposite direction of the duodenum when the endoscope cap (200) according to the present invention is positioned at the correct position by sensing the major duodenal papilla of the duodenum.
  • DHb deoxyhemoglobin concentration
  • BVR blood vessel radius
  • the pancreatic tumor diagnosis device may further include an indicator, although not shown in the drawing.
  • the indicator may be an element configured to be confirmed through the camera of the insertion tube (100). Accordingly, the user can confirm the directionality of the endoscope cap (200) by confirming the indicator through the camera of the insertion tube (100).
  • the endoscope cap (200) may be formed of an elastic material as described above, and may be positioned so as not to cover, or at least partially cover, the curved portion (120) of the insertion tube (100). Accordingly, the endoscope cap (200) may be partially bent to correspond to the shape of the duodenum, and thus, the user may observe the duodenal mucosa more accurately.
  • FIG. 7 is a drawing for explaining one embodiment of the internal structure of the endoscope cap (200) of FIG. 1.
  • the pancreatic tumor diagnosis device may further include a configuration for collecting pancreatic juice and duodenal fluid within the duodenum.
  • the pancreatic tumor diagnostic device may further include a passage (241) formed in the endoscope cap (200) and communicating with the outside.
  • the passage (241) may be a passage through which pancreatic fluid and duodenal fluid flow in by communicating with the outside.
  • the endoscope cap (200) according to the present invention is positioned adjacent to or in contact with the major duodenal papilla and is used to directly collect pancreatic juice and duodenal fluid discharged from the major duodenal papilla.
  • the endoscope cap (200) may further include a sensor for detecting the type of body fluid flowing into the port (241).
  • the endoscope cap (200) may detect if the body fluid flowing into the port (241) is pancreatic fluid and/or duodenal fluid and provide an alarm to the user.
  • a sensor included in the endoscope cap (200) may be a pH sensor. Since pancreatic fluid is alkaline with a pH>8, the pH sensor disposed in the endoscope cap (200) may detect the type of body fluid flowing into the port (241).
  • the endoscope cap (200) according to the present invention may further include a fluid storage hole (242) for storing pancreatic fluid introduced through the hole (241).
  • the fluid storage hole (242) can be communicated with the passage hole (241). Therefore, pancreatic fluid flowing in through the passage hole (241) can be stored in the fluid storage hole (242).
  • the fluid storage hole (242) may further include a valve that blocks the flow of pancreatic fluid and duodenal fluid to prevent the introduced pancreatic fluid from leaking out.
  • the endoscope cap (200) according to the present invention may further include a suction hole (243) to provide suction force to more efficiently collect pancreatic juice discharged from the major duodenal papilla.
  • the pancreatic tumor diagnostic device includes an endoscope cap (200) formed to be extended to have a length and having a hole formed on the inside into which an insertion tube (100) is inserted, so that it can be introduced into the body of a patient during an endoscopic procedure and perform various functions.
  • a pancreatic tumor diagnosis device can measure DHb (Deoxyhemoglobin Concentration), BVR (Blood Vessel Radius) and vascular stiffness inside the duodenum of a patient by including a plurality of LED sensors (230) arranged on the outside of an endoscope cap (200).
  • DHb Deoxyhemoglobin Concentration
  • BVR Bood Vessel Radius
  • vascular stiffness inside the duodenum of a patient by including a plurality of LED sensors (230) arranged on the outside of an endoscope cap (200).
  • the pancreatic tumor diagnosis device is formed so that the endoscope cap (200) is positioned at a position spaced apart from the distal portion (101) of the insertion tube (100) by a predetermined distance, preferably, to surround at least a portion of the curved portion (120) of the insertion tube (100), and is extended to have a length, so that there is an effect of improving the diagnostic length of the duodenum inside the duodenum.
  • DHb Deoxyhemoglobin Concentration
  • BVR Blood Vessel Radius
  • the pancreatic tumor diagnosis device can more accurately measure DHb (Deoxyhemoglobin Concentration), BVR (Blood Vessel Radius) and vascular stiffness by irradiating light of different wavelengths with an LED sensor (230) placed in an endoscope cap (200), thereby more accurately and quickly diagnosing the presence of a pancreatic tumor, etc.
  • DHb Deoxyhemoglobin Concentration
  • BVR Blood Vessel Radius
  • vascular stiffness by irradiating light of different wavelengths with an LED sensor (230) placed in an endoscope cap (200), thereby more accurately and quickly diagnosing the presence of a pancreatic tumor, etc.
  • the pancreatic tumor diagnosis device has an endoscope cap (200) formed of a transparent material so that diagnosis of a pancreatic tumor can be performed simultaneously with a general endoscopic procedure, and includes a through hole (241) for collecting pancreatic fluid and duodenal fluid during the procedure so that collection of pancreatic fluid and duodenal fluid can also be performed simultaneously.
  • pancreatic cancer Through the collected fluids, the possibility of early diagnosis of pancreatic cancer can be maximized by analyzing the changes in the composition of the intestinal microbiome and the microRNA of the extracellular vesicles, which are helpful for the early diagnosis of pancreatic cancer.
  • the user can also inject the patient with secretin, a hormone that increases pancreatic secretion, during the procedure to efficiently collect pancreatic and duodenal fluids.
  • optical and fluid biomarker information obtained through these pancreatic tumor diagnostic devices can be obtained during a routine endoscopic examination, and if an abnormality is found, a detailed examination such as CT/MRI can be performed.
  • a detailed examination such as CT/MRI
  • early pancreatic cancer can be diagnosed using the changes in optical and fluid biomarkers obtained during endoscopic examinations every 6 months or 1 year.
  • a pancreatic tumor diagnosis device can be provided.
  • embodiments of the present invention can be applied to a welding information providing device used in industry.

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Abstract

La présente invention concerne un dispositif de diagnostic de tumeur pancréatique, et un dispositif de diagnostic de tumeur pancréatique, qui peut être facilement fixé à la muqueuse duodénale et permet un diagnostic précoce rapide et précis du cancer du pancréas. Un aspect de la présente invention peut comprendre : un tube d'insertion s'étendant pour être inséré dans le corps d'un patient, et comprenant une partie d'extrémité distale et une partie d'extrémité proximale ; un capuchon d'endoscope, qui est disposé pour englober la surface circonférentielle externe du tube d'insertion, s'étend pour avoir une longueur, et est disposé à une position espacée d'une distance prédéterminée de la partie d'extrémité distale du tube d'insertion ; et une pluralité de capteurs à DEL disposés sur la surface du capuchon d'endoscope.
PCT/KR2024/015260 2023-10-16 2024-10-08 Dispositif de diagnostic de tumeur pancréatique Pending WO2025084693A1 (fr)

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KR1020230137882A KR20250054902A (ko) 2023-10-16 2023-10-16 췌장 종양 진단 장치
KR10-2023-0137882 2023-10-16

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WO2025084693A1 true WO2025084693A1 (fr) 2025-04-24

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001224554A (ja) * 2000-02-15 2001-08-21 Asahi Optical Co Ltd 内視鏡用ドレナージチューブ
WO2016047191A1 (fr) * 2014-09-25 2016-03-31 オリンパス株式会社 Systeme d'endoscope
JP2019150388A (ja) * 2018-03-05 2019-09-12 五稜化薬株式会社 内視鏡用アプリケータ装置
JP2019534766A (ja) * 2016-09-23 2019-12-05 セイフビュー メディカル, エルエルシーSafeview Medical, Llc 体内の画像化のための装置及び方法
KR20220145685A (ko) * 2021-04-22 2022-10-31 재단법인 아산사회복지재단 Led 내시경 캡을 이용한 저준위 레이저 치료기

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001224554A (ja) * 2000-02-15 2001-08-21 Asahi Optical Co Ltd 内視鏡用ドレナージチューブ
WO2016047191A1 (fr) * 2014-09-25 2016-03-31 オリンパス株式会社 Systeme d'endoscope
JP2019534766A (ja) * 2016-09-23 2019-12-05 セイフビュー メディカル, エルエルシーSafeview Medical, Llc 体内の画像化のための装置及び方法
JP2019150388A (ja) * 2018-03-05 2019-09-12 五稜化薬株式会社 内視鏡用アプリケータ装置
KR20220145685A (ko) * 2021-04-22 2022-10-31 재단법인 아산사회복지재단 Led 내시경 캡을 이용한 저준위 레이저 치료기

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