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WO2025084073A1 - Système de traitement à faisceau de particules et son procédé de commande - Google Patents

Système de traitement à faisceau de particules et son procédé de commande Download PDF

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Publication number
WO2025084073A1
WO2025084073A1 PCT/JP2024/033511 JP2024033511W WO2025084073A1 WO 2025084073 A1 WO2025084073 A1 WO 2025084073A1 JP 2024033511 W JP2024033511 W JP 2024033511W WO 2025084073 A1 WO2025084073 A1 WO 2025084073A1
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WIPO (PCT)
Prior art keywords
particle beam
irradiation
therapy system
particle
control device
Prior art date
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PCT/JP2024/033511
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English (en)
Japanese (ja)
Inventor
凌峰 張
伸一郎 藤高
孝明 藤井
博樹 白土
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Hokkaido University NUC
Hitachi Ltd
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Hokkaido University NUC
Hitachi Ltd
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Publication of WO2025084073A1 publication Critical patent/WO2025084073A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K5/00—Irradiation devices
    • G21K5/04—Irradiation devices with beam-forming means

Definitions

  • the present invention relates to a particle beam therapy system and a control method thereof.
  • PBT Particle beam therapy
  • particles such as protons or carbon ions
  • a Bragg peak which allows the therapeutic dose to be concentrated in a narrow area. Therefore, compared to conventional photon beam radiation therapy, PBT can destroy tumors while sparing most of the surrounding healthy tissue.
  • the range of particle beams also called beams
  • the range of particle beams is easily affected by the body tissues through which they pass, so even a slight change in the body tissues can significantly change the beam range. Therefore, obtaining the range (also called beam range) of the particle beam in real time during treatment is important to deliver an accurate dose to the affected area.
  • One method for determining the range of a particle beam in real time is to detect secondary radiation that occurs when the particle beam stops inside the patient's body (Patent Document 1).
  • Patent Document 1 When the particle beam enters the patient's body, gamma rays are instantly emitted due to the interaction between the particle beam and the biological tissue. By detecting these gamma rays, the reach (range) of the beam can be determined in real time.
  • Non-Patent Document 1 proposes the idea of using a particle beam containing a mixture of helium and carbon to simultaneously treat the affected area and measure the distance traveled.
  • Patent Document 1 Problems with Patent Document 1 include the low signal-to-noise ratio of prompt gamma rays and the difficulty in finding suitable detectors.
  • Patent Document 2 since the patient's internal structure information is not sufficient, the beam range from the body surface to the target cannot be accurately known, and therefore, it is difficult for Patent Document 2 to accurately adjust the beam energy for treating the patient.
  • Non-Patent Document 1 the area in which the technology described in Non-Patent Document 1 can be applied is limited by the energy ratio of the two particle beams. Furthermore, using different types of particle beams separately for distance measurement and treatment introduces additional uncertainty.
  • the present invention was made in consideration of the above problems, and provides a particle beam therapy system and a control method thereof that can irradiate particle beams more effectively.
  • the particle beam therapy system includes an irradiation device that irradiates particle beams and a control device that controls the irradiation device, and the control device causes the irradiation device to irradiate multiple particle beams of the same type but for different purposes at different times to the irradiation target.
  • multiple particle beams of the same type can be irradiated from an irradiation device to an object at different times.
  • FIG. 1 is a diagram showing the system configuration for irradiating an affected area with a transmitted beam used for estimating a beam range and a treatment beam used for treatment at different timings.
  • FIG. 4 is an explanatory diagram showing the relationship between the range and the dose of the first beam and the second beam.
  • FIG. 4 is an explanatory diagram showing an example of a scanning pattern of a first beam and a second beam.
  • FIG. 11 is an explanatory diagram showing another example of the scanning pattern of the first beam and the second beam in the second embodiment.
  • FIG. 10A and 10B are explanatory diagrams showing modified examples of the scanning patterns of the first beam and the second beam.
  • FIG. 13 is an explanatory diagram showing how a beam is irradiated using a scatterer in the third embodiment. 13 is a flowchart of an irradiation control process according to the fourth embodiment.
  • FIG. 13 is an overall view of a particle beam therapy system according to a fifth embodiment.
  • FIG. 13 is an overall view of a particle beam therapy system according to a sixth embodiment.
  • the irradiation range (range of flight) of the beam is estimated in real time, and the energy, intensity, and irradiation angle of the therapeutic beam are controlled using the estimation results.
  • the dose of the therapeutic beam can be calculated, and an accurate dose can be delivered to the affected area in accordance with the treatment plan.
  • the range of the beam within the patient's body may be referred to as the beam range.
  • the first beam is used to measure the range of the beam inside the body of a patient as the irradiation target.
  • the first beam can be called a transmission beam, an imaging beam, or a range estimation beam.
  • the second beam is used to treat the affected area.
  • the second beam can be called a treatment beam.
  • the first beam which is irradiated first, estimates the spot to be set on the affected area or the beam range around that spot, and based on the estimation result, the second beam is irradiated to each spot to deliver a predetermined dose.
  • the second beam is irradiated promptly after the first beam is irradiated.
  • the first beam has higher energy and lower intensity than the second beam.
  • the second beam has lower energy and higher intensity than the first beam.
  • the energy of the beam is the individual kinetic energy of each particle in the beam. It determines how far into the body the particles can reach (i.e., the beam range). If the beam has enough energy, it will penetrate the patient and be stopped at a detector.
  • the intensity of the beam is the number of particles in the beam. It determines how many particles are delivered to a particular location in the patient, i.e., the dose.
  • the first beam has high energy to pass through the patient's body, but low intensity to minimize the dose given to the patient.
  • the second beam has low energy to stop the particles at the affected area, but high intensity to give a large dose to the affected area.
  • the residual energy of the first beam that has passed through the patient's body is detected, and the beam range is estimated based on the detected residual energy and information indicating the patient's internal structure.
  • the energy, intensity, and irradiation angle of the second beam are adjusted based on the estimation result, and the second beam is irradiated to the affected area.
  • Information showing the patient's internal body structure can be obtained, for example, from CT (Computed Tomography) images, MRI (Magnetic Resonance Imaging) images, or X-ray images.
  • CT Computer Tomography
  • MRI Magnetic Resonance Imaging
  • X-ray images X-ray images.
  • the internal body structure is photographed using 4D CT to construct a motion model and obtain the internal body structure in real time.
  • the beam range is estimated in real time and the second beam is controlled based on the estimation result, so the dose given to the patient (affected area) can be accurately managed. Furthermore, according to the present disclosure, the dose can be accurately managed by tracking the patient's movements during particle beam therapy.
  • Fig. 1 shows the overall configuration of a particle beam therapy system.
  • Fig. 2 shows an example of a configuration in which a transmitted beam used to estimate the beam range and a treatment beam used for treatment are irradiated to the affected area at different times.
  • the particle beam therapy system includes, for example, a particle beam generator 10, a beam transport system 20, an irradiation device 25, a couch 32, and a beam irradiation control device 40.
  • the irradiation device 25 and the couch 32 are arranged in a treatment room 30.
  • the particle beam generator 10 includes, for example, an ion source 11, a circular accelerator 12, a high-frequency application device 13, a high-frequency power supply 14, and an extraction septum magnet 15.
  • the particle beam generator 10 generates a plurality of types of beams B1, B2 made of the same particles and differing in energy and intensity, and supplies them to the irradiation device 25.
  • the particle beam generator 10 can switch between generating a first beam B1 that passes through the patient 31 to take an image, and a second beam B2 that provides a predetermined dose to the affected area 310 of the patient 31 (see FIG. 2) to treat the area.
  • the first beam B1 may be referred to as a transmitted beam B1.
  • the second beam B2 may be referred to as a treatment beam.
  • the circular accelerator 12 is a device that accelerates charged particles using a time-frequency modulated high-frequency electric field in a main magnetic field of constant strength.
  • the energy of the charged beam extracted from the circular accelerator 12 is variable between 70 and 235 MeV.
  • Charged particles supplied from the ion source 11 are injected into a beam acceleration region (not shown) inside the main electromagnet (not shown) of the circular accelerator 12.
  • the charged particles are subjected to the Lorentz force from the magnetic field excited by the main electromagnet and orbit within the circular accelerator 12.
  • the high-frequency electric field is frequency modulated in accordance with the period of the orbital motion.
  • an extraction start signal is output from the beam irradiation control device 40 to the particle beam generator 10.
  • This causes high-frequency power generated by the high-frequency power supply 14 to be applied to the charged particles orbiting the circular accelerator 12 from a high-frequency application electrode (not shown) installed in the high-frequency application device 13.
  • This causes beams B1 and B2 to be kicked out of the orbit by a high-frequency kicker (not shown), deflected by the extraction septum electromagnet 15, and extracted to the beam transport system 20.
  • the circular accelerator 12 accelerates the beam along an eccentric orbit within a magnetic field excited by a superconducting electromagnet. Furthermore, the circular accelerator 12 is provided with a channel for extracting the beam outside the orbit concentration region through which beams of each energy pass in common. This allows the circular accelerator 12 to extract a beam of any energy using a high-frequency kicker.
  • a cyclotron, synchrotron, synchrocyclotron, etc. may also be used.
  • the beam transport system 20 is equipped with multiple quadrupole electromagnets (not shown) and a bending electromagnet 21, and is connected to the particle beam generator 10 and the irradiation device 25.
  • a part of the beam transport system 20 and the irradiation device 25 are installed in a substantially cylindrical gantry 26 inside the treatment room 30, and can rotate together with the gantry 26.
  • the beams B1 and B2 emitted from the particle beam generator 10 are converged by the quadrupole electromagnets as they pass through the beam transport system 20, and then their direction is changed by the bending electromagnet 21 before entering the irradiation device 25.
  • the irradiation device 25 includes, for example, two pairs of scanning electromagnets 251 and 252, a dose monitor 254, and a position monitor 253.
  • the two pairs of scanning electromagnets 251 and 252 are installed in mutually orthogonal directions, and can deflect the beams B1 and B2 so that the beams B1 and B2 reach desired positions in a plane perpendicular to the beam axis at the target position.
  • the dose monitor 254 is a monitor that measures the dose of the beams B1 and B2 irradiated to the target.
  • the detected measurement value is output to the beam irradiation control device 40.
  • the position monitor 253 is a monitor that detects the passing position of the beams B1 and B2 irradiated to the diseased area 310, which is the target, and outputs the detected detection value to the beam irradiation control device 40.
  • the beams B1 and B2 that pass through the irradiation device 25 reach the target 310 in the patient 31, who is the irradiation subject. Note that when treating a patient with cancer or the like, the irradiation subject 31 represents the patient, and the target 310 represents a tumor or the like.
  • the first beam B1 is used to measure the range of the beam at the diseased area 310, and is not used for treatment. Treatment of the diseased area 310 is performed by the second beam B2.
  • the bed on which the irradiation target 31 is placed is called the couch 32.
  • the couch 32 can move in the directions of three orthogonal axes and can also rotate around each axis based on instructions from the beam irradiation control device 40. Through these movements and rotations, the position of the irradiation target 31 can be moved to the desired position.
  • the beam irradiation control device 40 as a "control device” is connected to, for example, the particle beam generator 10, the beam transport system 20, the irradiation device 25, the couch 32, the storage device 43, the console 44, and the treatment plan creation device 50. Furthermore, the beam irradiation control device 40 is also connected to a detection unit 33 that detects the residual energy of the first beam B1 that has passed through the patient 31, and an internal body structure information estimation device 60. The residual energy detection unit 33 is disposed directly below the patient 31.
  • the internal body structure information estimation device 60 is an example of a device that extracts medical images. Other devices that detect respiratory phases and estimate internal body structures may also be used.
  • the beam irradiation control device 40 controls the particle beam generator 10, the beam transport system 20, the irradiation device 25, and other devices.
  • the beam irradiation control device 40 includes an internal body structure information acquisition unit 41 that acquires internal body structure information indicating the internal body structure of the patient 31, a beam range estimation unit 42 that estimates the beam range, and an irradiation protocol control unit 43.
  • the internal body structure information acquisition unit 41 acquires internal body structure information of the patient 31 based on a detection signal from an internal body structure information estimation device 60, which estimates information indicating the internal body structure.
  • the beam range estimation unit 42 estimates the range of the second beam B2 inside the patient 31 from the residual energy of the first beam B1 detected by the residual energy detector 33 and the internal body structure information acquired by the internal body structure information acquisition unit 41.
  • the irradiation protocol control unit 43 causes the irradiation device 25 to irradiate either the first beam B1 or the second beam B2 to a spot SP (see Figure 5) set on the target 310 according to a predetermined irradiation protocol based on the estimated beam range.
  • the beam irradiation control device 40 Before irradiating the patient 31 with the beams B1 and B2, the beam irradiation control device 40 acquires the irradiation parameters (gantry angle, planned spot data, etc.) created by the treatment plan creation device 50. The beam irradiation control device 40 stores the acquired irradiation parameters in the storage device 43.
  • the console 44 is connected to the beam irradiation control device 40 and displays information on a monitor (not shown) based on signals acquired from the beam irradiation control device 40. In addition, the console 44 receives input from medical personnel who operate the particle beam therapy system and transmits various control signals to the beam irradiation control device 40.
  • the irradiation protocol control unit 43 outputs a control signal to the therapist controller 432 according to the irradiation protocol 431.
  • the therapist controller 432 outputs a control signal to the particle beam generator 10, the beam transport system 20, and the irradiation device 25, thereby causing the first beam B1 to be irradiated from the irradiation device 25 toward the patient 31.
  • the first beam B1 has high energy and low intensity, so it passes through the patient 31 and enters the detector 33 located directly below the patient 31, and the residual energy is detected by the detector 33. Since the first beam B1 has a low intensity, the dose given to the patient 31 is small.
  • the residual energy of the first beam B1 detected by the detection unit 33 is input to the beam range estimation unit 42.
  • the internal body structure information acquisition unit 41 acquires internal body structure information from the respiratory phase of the patient 31 acquired by the internal body structure information estimation device 60, and inputs the information to the beam range estimation unit 42.
  • the beam range estimation unit 42 estimates the range (beam range) of the second beam B2 in the body of the patient 31 based on the residual energy of the first beam B1 that has passed through the body of the patient 31 and the internal structure information of the patient 31 obtained by the internal structure information acquisition unit 41. Based on the estimated beam range and the internal structure information, the irradiation protocol control unit 43 adjusts parameters such as the energy, intensity, and irradiation angle of the second beam, and causes the irradiation device 25 to irradiate the second beam B2 to the patient 31 (more precisely, the affected area 310).
  • the number of irradiations of the first beam B1 and the number of irradiations of the second beam B2 may correspond one-to-one or one-to-many.
  • the particle beam therapy system irradiates the affected area 310 with the second beam B2 by pencil beam scanning, and gives a predetermined dose to the affected area 31.
  • An example of a scanning pattern will be described later.
  • the beam range estimated by the beam range estimation unit 42 can also be used for motion management that manages the movement of the patient 31.
  • 4DCT or a motion model capable of describing internal structure information at any instant may be prepared, and internal structure information may be obtained from the motion model.
  • internal structure information may be calculated by measurements made by the internal structure information estimation device 60, such as particle-based 4DCT or a corresponding motion model. This makes it possible to obtain a more direct correlation between the internal structure during respiratory movement and the residual energy.
  • the accuracy of internal structure information obtained based on non-particle measurements, such as 4DCT or a motion model based on 4DCT, can be improved by performing calibration according to the beam range based on the measured residual energy.
  • Figure 3 shows the relationship between the range and the dose of the first beam B1 and the second beam B2. Since the first beam B1 has high energy, it passes through the patient 31 and enters the detection unit 33. However, since the first beam B1 has low intensity, its residual energy is small. The dose that the first beam B1 gives to the patient 31 is also small.
  • the second beam B2 has its parameters, such as energy, intensity, and irradiation angle, adjusted based on the beam range estimated from the residual energy of the first beam B1. Since the second beam B2 has low energy, it does not pass through the body of the patient 31. The end of the range of the second beam B2 is set at a specified location on the affected area 310, and a large dose is delivered to that specified location.
  • FIG 4 is a schematic diagram showing a method of CT imaging of a patient using a 4DCT system.
  • An X-ray tube 61 rotates around a patient 31, and X-rays passing through the patient 31 are detected by a detector 62.
  • a marker 63 is placed on the body surface of the patient 31, and the movement of the marker 63 is recorded by a camera 64.
  • a 4DCT is constructed using the signal detected by the X-ray detector 62 and the movement of the body surface recorded by the camera 64.
  • the 4DCT provides structural information about how body tissues move over time during breathing. Typically, it is divided into 10 respiratory phases depending on the movement amplitude of the marker 63. Thus, the position of biological tissues in 10 different respiratory phases can be determined.
  • Information from the 4DCT can be combined with an internal structure information estimation device 60 to obtain approximate positions of body tissues in real time.
  • the internal structure information estimation device 60 can obtain the real-time aperture position at a certain moment.
  • the phase of the 4D CT that gives the closest diaphragm position can be identified, thereby determining the patient's 3D anatomy at that moment.
  • a model can be built first from the 4D CT, and when combined with the diaphragm (or other surrogate) motion obtained from the internal structure information estimation device 60, real-time structural information can be available at any time during treatment.
  • the scanning pattern of the first beam and the second beam will be described using Figure 5.
  • the scanning pattern is managed as an irradiation protocol of the irradiation protocol control unit 43.
  • a plurality of spots SP are set as "irradiation areas" on the affected area.
  • the upper part of Figure 5 shows a timing chart for the irradiation of each beam B1, B2.
  • the lower part of Figure 5 shows the scanning pattern of each beam B1, B2.
  • the scanning pattern of the first beam B1 is shown by a solid line
  • the scanning pattern of the second beam is shown by a dotted line.
  • the first beam B1 used to estimate the beam range is scanned as if filling in a certain area, folding back from spot SP1 ⁇ spot SP2 ⁇ spot SP3 ⁇ spot SP4 ⁇ spot SP5 ⁇ spot SP7 ⁇ spot SP8 ⁇ spot SP9 ⁇ spot SP10 ⁇ spot SP11 ⁇ spot SP12 ⁇ spot SP13 ⁇ spot SP14 ⁇ spot SP15 ⁇ spot SP16.
  • the second beam B2 which is used to deliver a prescribed dose determined by the treatment plan to the affected area, is scanned so as to follow the first beam B1.
  • the movement trajectory of the first beam B1 and the movement trajectory of the second beam B2 coincide with each other.
  • the beam range is estimated for each spot SP, and a second beam adjusted based on the estimation result is irradiated.
  • the delay time ⁇ t from the end of irradiation of the first beam B1 to the start of irradiation of the second beam B2 is set as short as possible. In the time chart of FIG.
  • the beam switching time ⁇ t is shown as if it were shorter than the beam irradiation interval t1 or t2, but in reality, the beam switching time ⁇ t is longer than the beam irradiation interval t1 or t2 ( ⁇ t >> t1, t2). This is because it takes a long time for the beam energy to change.
  • the beam range inside the patient's body can be estimated based on the residual energy of the first beam B1 and internal body structure information, and treatment can be performed using the second beam B2 adjusted based on the estimated beam range.
  • the beam range can be estimated in real time while treatment is being performed with the second beam B2, so the specified dose determined in the treatment plan can be accurately delivered to the affected area.
  • the beam range is estimated for each spot, so the estimation accuracy can be improved, and as a result, the irradiation parameters of the second beam B2 can be accurately adjusted.
  • the beam range estimated in real time can also be used for motion management, enabling even more accurate particle beam therapy to be achieved.
  • the particle beam therapy system of this embodiment uses multiple beams B1 and B2 that are made of the same type of particles but have different properties, so the range in which the beam range can be estimated and the range in which treatment can be performed can be made to almost match, making the range of application wider than that of the technology described in Non-Patent Document 1 and easier to use.
  • Non-Patent Document 1 claims that He2+ and C6+ can be accelerated together because they have the same mass-to-charge ratio (He2+ has a mass of 4 amu, C6+ has a mass of 12 amu, and both have a mass-to-charge ratio of 2).
  • He2+ and C6+ can be accelerated together because they have the same mass-to-charge ratio (He2+ has a mass of 4 amu, C6+ has a mass of 12 amu, and both have a mass-to-charge ratio of 2).
  • the stopping power of He2+ is different from that of C6+, when He2+ and C6+ reach a certain speed, C6+ stops near the tumor and He2+ penetrates the patient.
  • This relationship between He2+ and C6+ limits the energy range that can be applied to both beam range measurement and treatment. For example, when using low-energy C6+ to treat a tumor near the skin, He2+ may not have enough energy to penetrate the patient and reach the detector. Conversely, when using high
  • the particle beam therapy system of this embodiment uses beams B1 and B2 that are made of the same particles but have different properties (energy and intensity), so the range in which both beam range estimation and treatment can be performed can be expanded, making it possible to realize an easy-to-use particle beam therapy system.
  • Example 2 will be described using FIG. 6. In the following examples, including this example, differences from Example 1 will be mainly described.
  • the first beam B1 is irradiated to one spot in a group unit consisting of a predetermined number of spots among the spots SP, and the second beam B2 is irradiated to each spot included in the group.
  • Examples 1-3 have the same spot arrangement.
  • the time chart in FIG. 6 shows the beam switching time ⁇ t as if it were shorter than the beam irradiation interval t12, but in reality, the beam switching time ⁇ t is longer than the beam irradiation interval t12 ( ⁇ t>>t12).
  • the first beam B1 is irradiated at spot SP1 to estimate the beam range
  • the second beam B2 is irradiated from spots SP1 to SP7 according to the estimation result. This completes the beam range estimation and treatment for one group.
  • the first beam B1 is irradiated at the next spot SP8 to estimate the beam range
  • the second beam B2 is irradiated from spots SP8 to SP15 according to the estimation result. This completes the beam range estimation and treatment for the second group.
  • the number of spots included in each group may be the same or different. For example, one group may be composed of a small number of spots and another group may be composed of a larger number of spots. If the time required to change the beam irradiation angle is not an issue, the first beam B1 may be irradiated to spots other than the first spot of the group to estimate the beam range, and the second beam B2 may be irradiated in order from the first spot of the group. For example, in the example of FIG.
  • the first beam B1 may be irradiated to spot SP6 to estimate the beam range, and then the beam irradiation angle of the irradiation device 25 may be changed to spot SP1, and the second beam B2 may be irradiated from spot SP1 to spot SP7.
  • the present embodiment thus configured also achieves the same effects as those of the first embodiment.
  • the first beam B1 is irradiated at the first spot of the group to estimate the beam range of the entire group, and the estimated result is used to irradiate each spot in the group with the second beam B2 for treatment, so that the frequency of switching between the first beam B1 and the second beam B2 can be reduced, as shown in the timing chart of Fig. 6.
  • the second beam B2 is irradiated to a plurality of spots.
  • the irradiation interval t12 of the second beam B2 is substantially the same as the irradiation interval t2 of the first embodiment. Therefore, in this embodiment, the first beam B1 and the second beam B2 can be switched and irradiated more efficiently than in the first embodiment.
  • this modified example irradiates one spot with the first beam B1 in units of a group consisting of a predetermined number of spots among the spots SP, and irradiates each spot included in the group with the second beam B2.
  • a zigzag scanning pattern is adopted.
  • the time chart in FIG. 7 shows the beam switching time ⁇ t as if it were shorter than the beam irradiation interval t22, but in reality, the beam switching time ⁇ t is longer than the beam irradiation interval t22 ( ⁇ t>>t22).
  • the modified example configured in this manner also achieves the same effects as Example 2.
  • the shape of the group, the number of spots included in the group, the size of the spots, and the position of the spot in the group to which the first beam B1 is irradiated to estimate the beam range can be set according to the needs of the medical technician.
  • the configuration of the group and the position of the spot used to estimate the beam range may be calculated using a so-called machine learning technique.
  • Example 3 will be described with reference to FIG. 8.
  • each of the beams B1 and B2 is irradiated to the patient 31 using passive beam scattering.
  • the first beam B1 is scattered by the scatterer 70 and passes through the patient 31, and the beam range is estimated from the residual energy after passing through the human body and internal body structure information.
  • the second beam B2 is scattered by the scatterer 70 and irradiated to the affected area 310, providing a predetermined dose.
  • the 4D CT system 60 can be used to obtain internal body structure information, roughly estimate the positions of internal body tissues divided into several phases, and use the estimation results to irradiate the second beam 2 to the affected area 310.
  • This embodiment configured in this manner also has substantially the same effect as the first embodiment.
  • the beams B1 and B2 are scattered using the scatterer 50, so that the patient can be treated while estimating the beam range more efficiently.
  • one of the scanning patterns described in FIG. 5 and the scanning patterns described in FIG. 6 or FIG. 7 can be selected before the start of treatment.
  • the beam irradiation control device 40 acquires a treatment plan from the storage device 43 (S10), and acquires internal body structure information from the 4DCT system 60 (S11). Furthermore, the beam irradiation control device 40 sets an irradiation protocol according to the requirements of the medical technician, who is the user of the particle beam therapy system (S12). The medical technician selects one of the scanning patterns described in FIG. 5 and the scanning patterns described in FIG. 6 or FIG. 7. That is, either a method of estimating the beam range for each spot or a method of estimating the beam range for a group including multiple spots is selected.
  • the beam irradiation control device 40 executes steps S14 to S19 for all spots to be irradiated as defined in the treatment plan (S13). That is, the beam irradiation control device 40 irradiates a certain spot with the first beam to obtain the residual energy (S14), and corrects the internal body structure information using the obtained residual energy (S15). Step S15 is a pre-treatment calibration. Next, the beam irradiation control device 40 irradiates the first beam again and obtains the residual energy (S16). The beam irradiation control device 40 estimates the beam range from the residual energy and the internal body structure information (S17).
  • the beam irradiation control device 40 sets irradiation parameters such as the energy (kinetic energy), intensity, and irradiation angle of the second beam B2 based on the beam range, the internal body structure information, and the treatment plan (S18).
  • the beam irradiation control device 40 irradiates the second beam B2 with the adjusted irradiation parameters to a predetermined spot (S19).
  • This embodiment configured in this manner also achieves the same effects as embodiment 1. Furthermore, this embodiment allows the user to select between a method of estimating the beam range for each spot and a method of estimating the beam range for each group including multiple spots, improving usability.
  • a particle beam generator 10(1) that generates a first beam B1 and a particle beam generator 10(2) that generates a second beam B2 are installed separately.
  • the beam irradiation control device 40A switches between the two particle beam generators 10(1) and 10(2) in a predetermined order to output beams B1 and B2 from the irradiation device 25A. Note that signal lines are omitted as appropriate in FIG. 10 and FIG. 11, which will be described later.
  • the present embodiment thus configured achieves the same effects as those of the first embodiment.
  • the particle beam generator 10 of the first embodiment can output beams B1 and B2 with different properties from a single unit, the introduction cost of the particle beam therapy system of the first embodiment is lower.
  • the sixth embodiment will be described with reference to FIG. 11.
  • the particle beam generator 10B used in the particle beam therapy system of this embodiment is equipped with two extraction septum magnets (exits) 15(1) and 15(2), and separate beam transport systems 20(1) and 20(2) are connected to these two exits.
  • the beam transport systems 20(1) and 20(2) are connected to the irradiation device 25B.
  • the beam irradiation control device 40B switches between the two exits 15(1) and 15(2) and the two beam transport systems 20(1) and 20(2) to use beams B1 and B2 in a predetermined order.
  • This embodiment configured in this manner also achieves the same effects as those of the fifth embodiment.
  • the introduction cost of the particle beam therapy system can be reduced compared to the fifth embodiment.
  • the present invention is not limited to the above-described embodiment.
  • a person skilled in the art can make various additions and modifications within the scope of the present invention.
  • the above-described embodiment is not limited to the configuration example shown in the attached drawings.
  • the configuration and processing method of the embodiment can be modified as appropriate within the scope of achieving the object of the present invention.
  • a particle beam therapy system that includes an irradiation device that irradiates particle beams and a control device that controls the irradiation device, and the control device causes the irradiation device to irradiate multiple particle beams of the same type but for different purposes at different times to an irradiation target.
  • Representation 2 A particle beam therapy system as described in Representation 1, in which the different types of particle beams include a first particle beam for measuring the range of the particle beam in the irradiation target, and a second particle beam used to treat the irradiation target.
  • Representation 3 A particle beam therapy system according to Representation 1 or 2, in which the first particle beam is irradiated to the irradiation target prior to the second particle beam.
  • (Representation 4) A particle beam therapy system according to any one of Representations 1-3, in which the first particle beam is a particle beam having higher energy and lower intensity than the second particle beam, and the second particle beam is a particle beam having lower energy and higher intensity than the first particle beam.
  • (Representation 5) A particle beam therapy system according to any one of Representations 1-4, in which the control device estimates range information indicating the range of the second particle beam in the irradiation target based on information indicating the internal structure of the irradiation target and the residual energy when the first particle beam passes through the irradiation target, and controls the second particle beam based on the estimated range information to irradiate the second particle beam to the irradiation target.
  • (Representation 7) A particle beam therapy system according to any one of Representations 1-6, in which the control device sets a plurality of irradiation regions for irradiating the particle beam on the irradiation target, and causes the irradiation device to irradiate the first particle beam and the second particle beam for each irradiation region.
  • (Representation 8) The particle beam therapy system described in any one of Representations 1-7, in which the control device sets a plurality of irradiation areas for irradiating the irradiation target with a particle beam, irradiates the first particle beam from the irradiation device in groups consisting of a predetermined plurality of irradiation areas among the plurality of set irradiation areas, and irradiates the second particle beam from the irradiation device for each of the predetermined plurality of irradiation areas included in the group.
  • (Representation 9) A particle beam therapy system according to any one of Representations 1-8, in which the control device can select whether to estimate the range information for each of a plurality of irradiation regions set for irradiating the irradiation target with a particle beam, or to estimate the range information for each group consisting of a predetermined number of irradiation regions among the plurality of irradiation regions.
  • Representation 10 A particle beam therapy system according to any one of Representations 1-9, in which the irradiation device irradiates the first particle beam and the second particle beam to the irradiation target via a scatterer that scatters and emits the incident particle beam.
  • Representation 11 A particle beam therapy system according to any one of Representations 1-10, in which the first particle beam and the second particle beam are supplied to the irradiation device from a common particle beam generating device.
  • a particle beam therapy system according to any one of Representations 1-11, further comprising a first particle beam generator that supplies the first particle beam to the irradiation device, and a second particle beam generator that supplies the second particle beam to the irradiation device.
  • a method for controlling a particle beam therapy system that includes an irradiation device that irradiates a particle beam and a control device that controls the irradiation device, in which the control device causes the irradiation device to irradiate a plurality of different types of particle beams to an irradiation target at different times.
  • 10, 10(1), 10(2), 10B Particle beam generator, 20, 20(1), 20(2): Beam transport system, 25, 25A, 25B: Irradiation device, 33: Residual energy detector, 40, 40A, 40B: Beam irradiation controller, 41: Internal body structure information acquisition unit, 42: Beam range estimation unit, 43: Irradiation protocol controller, 50: Treatment plan creation device, 60: 4DCT system, B1: First beam, B2: Second beam

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  • High Energy & Nuclear Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne un système de traitement à faisceau de particules susceptible de rayonner plus efficacement un faisceau de particules. Ce système de traitement à faisceau de particules comprend : un dispositif de rayonnement 25 permettant de rayonner des faisceaux de particules B1, B2 ; et un dispositif de commande 40 permettant de commander le dispositif de rayonnement. Le dispositif de commande amène la pluralité de faisceaux de particules B1, B2, qui sont à des fins différentes mais sont du même type, à être rayonnés depuis le dispositif de rayonnement vers un sujet soumis à une exposition à un rayonnement 31 à différents moments.
PCT/JP2024/033511 2023-10-18 2024-09-19 Système de traitement à faisceau de particules et son procédé de commande Pending WO2025084073A1 (fr)

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JP2023179291A JP2025069524A (ja) 2023-10-18 2023-10-18 粒子線治療システムおよびその制御方法
JP2023-179291 2023-10-18

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020000272A (ja) * 2018-06-25 2020-01-09 株式会社日立製作所 放射線治療システム、プログラムおよび放射線治療システムの作動方法
JP2020532364A (ja) * 2017-08-31 2020-11-12 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ 心不整脈およびその他の疾患の治療のための炭素粒子療法のシステムおよび方法
JP2022152591A (ja) * 2021-03-29 2022-10-12 住友重機械工業株式会社 粒子線治療装置、及び加速器

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020532364A (ja) * 2017-08-31 2020-11-12 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ 心不整脈およびその他の疾患の治療のための炭素粒子療法のシステムおよび方法
JP2020000272A (ja) * 2018-06-25 2020-01-09 株式会社日立製作所 放射線治療システム、プログラムおよび放射線治療システムの作動方法
JP2022152591A (ja) * 2021-03-29 2022-10-12 住友重機械工業株式会社 粒子線治療装置、及び加速器

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