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WO2025081336A1 - Produit cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne - Google Patents

Produit cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne Download PDF

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Publication number
WO2025081336A1
WO2025081336A1 PCT/CN2023/124938 CN2023124938W WO2025081336A1 WO 2025081336 A1 WO2025081336 A1 WO 2025081336A1 CN 2023124938 W CN2023124938 W CN 2023124938W WO 2025081336 A1 WO2025081336 A1 WO 2025081336A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
composition
polyglyceryl
preferred
butylcyclohexanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2023/124938
Other languages
English (en)
Inventor
Na Li
Luan LUAN
Xiao Zhu
Cecile Ratschow
Donglin XIE
Hanjun CHEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nivea Shanghai Co Ltd
Beiersdorf AG
Original Assignee
Nivea Shanghai Co Ltd
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nivea Shanghai Co Ltd, Beiersdorf AG filed Critical Nivea Shanghai Co Ltd
Priority to PCT/CN2023/124938 priority Critical patent/WO2025081336A1/fr
Priority to PCT/EP2024/079018 priority patent/WO2025082967A1/fr
Priority to CN202411452536.7A priority patent/CN119837773A/zh
Publication of WO2025081336A1 publication Critical patent/WO2025081336A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/34—Free of silicones

Definitions

  • the present invention belongs to the cosmetic field and relates to a cosmetic composition comprising 4-t-butylcyclohexanol and ectoine.
  • Cosmetic products generally not only serve to look beautiful and attractive, but their effects make a decisive contribution to increased self-esteem and people's wellbeing. Accordingly, a wide variety of cosmetic products are used for the daily cleaning and care of human skin.
  • a well-known group of cosmetic products are body lotions and cosmetic face care products.
  • the formulations are usually formulated as oil in water emulsion or are in gel form.
  • the appearance of this pilling effect can be controlled by carefully choosing the ingredients contained in the formulations.
  • the pilling effect will be found to be increased with increasing molecular weight of polymers and with increasing amount of those polymers in the formulations. Powders like silica or starch might further increase the pilling risks when been used together with those polymers.
  • the most common used polymers in body lotions and cosmetic face care products are polymers formed by homo-or copolymerization with acrylic acid, methacrylic acid and/or vinylpyrrolidone. Due to their properties, they can be used at low molecular weight and usually only limited amounts of those polymers are needed to provide formulas with sufficient rheological properties.
  • Further silicone oils and/or silicon derivatives offer a silky feeling which might also help decreasing the friction of skin when applying on the skin care product. Silicone derivatives are considered as those chemicals, which contain a [R 1 R 2 SiO] n subunit, wherein R 1 and R 2 each is an alkyl group and n can be 1 or larger. Thus, in those formulas the effect of pilling can conveniently be controlled.
  • state of art formulations often comprises polyethyleneglycol derivatives as emulsifier, such as PEG-40 hydrogenated castor oil.
  • Polyethyleneglycol derivatives are considered as molecules comprising at least one (–CH 2 –CH 2 –O–) i unit, whereby i is an integer number which is 2 or larger.
  • i is an integer number which is 2 or larger.
  • 4-t-butylcyclohexanone is an ingredient occasionally used in cosmetic formulations.
  • the component is traded under the trade name 1609 in form of a clear synthetic liquid solution used for fast skin relief. It significantly alleviates stinging and burning by reducing stinging up to 78%after 3 minutes and burning up to 80%after 3 minutes. It is proven to smoothen scalp sensitivities of burning and stinging during chemical color treatment.
  • 4-t-butylcyclohexanone 1609 contains pentylene glycol.
  • Ectoine is used as an active ingredient in skin care and sun protection products. It stabilizes proteins and other cellular structures and protects the skin from stresses like UV irradiation and dryness.
  • the present invention can be used to reduce the pilling effects in cosmetics.
  • a first object of the present invention is a cosmetic composition comprising an aqueous phase and an oil phase and wherein the composition comprises, based on the total weight of the composition,
  • composition is free from polymers polymerized from a mixture comprising or consisting of acrylic acid, methacrylic acid and/or vinylpyrrolidone and the composition is free from silicone oils.
  • a second object of the invention is the use of 4-t-butylcyclohexanol and ectoine in a cosmetic composition comprising an oil phase and an aqueous phase to reduce the pilling effect of the composition on top of the human skin, whereby the composition is preferentially free from polymers polymerized from a mixture comprising or consisting of acrylic acid, methacrylic acid and/or vinylpyrrolidone and the composition is free from silicone oils.
  • the invention allows to reduce the pilling effect, which is in particular associated with the presence of natural gums as thickener in the formulations.
  • normal conditions refers to 25°C, 1013 hPa and a relative humidity of 50%.
  • the term “free from” means that the proportion of the respective substance is less than 0.01%by weight. This ensures that entrainments or impurities with these substances are not included as “free from” according to the invention.
  • skin refers solely to the human skin.
  • viscosity values relate to a measurement at 25°C. in a 150 ml wide-mouth bottle (VWR No.: 807-001) using Rheomat R 123 from the company proRheo.
  • the Rheomat R 123 from proRheo GmbH is a rotational viscometer, i. H. a measuring body rotates in the substance to be measured. The force required to rotate the measuring body in the sample at a specified speed is measured. The viscosity is calculated from this torque, the speed of the measuring body and the geometric dimensions of the measuring system used.
  • Measuring body No. 1 (Article No. 200 0191) , suitable for a viscosity range of up to 10,000 [mPa s] , speed range 62.5 min -1 , is used as the measuring body.
  • Emulsifiers are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name “emulsifying agent” .
  • Surfactants are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name “surfactant” .
  • composition according to the invention comprises 4-t-butylcyclohexanol. It is preferred if the total quantity of 4-t-butylcyclohexanol is in the range from 0.05 to 1.0%by weight, more preferably from 0.1 to 0.8%by weight and most preferably from 0.15 to 0.3%by weight, calculated to the total weight of the composition.
  • 4-t-butylcyclohexanol can be used in cis or in trans modification. According to the invention it is preferred if the composition comprises trans-4-t-butylcyclohexanol. It is particular preferred if the total quantity of trans-4-t-butylcyclohexanol is in the range from 0.05 to 1.0%by weight, more preferably from 0.1 to 0.8%by weight and most preferably from 0.15 to 0.3%by weight, calculated to the total weight of the composition.
  • both cis-and trans-4-t-butylcyclohexanol are contained it is preferred if the ratio by weight between cis-and trans-4-t-butylcyclohexanol is in the range from 100: 1 to 1: 100, more preferably 10: 1 to 1: 99 and most preferred 1: 1 to 1: 98.
  • the composition according to the invention comprises ectoine. It is preferred if the total quantity of ectoine is in the range from 0.05 to 0.9%by weight, more preferably from 0.1 to 0.8%by weight and most preferably from 0.15 to 0.4%by weight, calculated to the total weight of the composition.
  • the ratio by weight between the total quantity of 4-t-butylcyclohexanol and ectoine is in the range from 10: 1 to 1: 10, more preferably from 3: 1 to 1: 3 and most preferably 1: 1 to 1: 2.
  • the total quantity of the oil phase in the cosmetic composition is in the range from 0.1 to 5.0%by weight, more preferably 0.2 to 2.5%by weight and most preferably from 0.3 to 2.0%by weight, calculated to the total weight of the composition.
  • the total amount of emulsifier and surfactants do not count to the amount of the oil phase.
  • the oil phase comprises at least one further branched alcohol having 14 to 26 carbon atoms. It is preferred if the at least one further branched alcohol is selected from alcohols having 16 to 24 carbon atoms, more preferably 18 to 22 carbon atoms and most preferably 20 carbon atoms.
  • the total quantity of the at least one further branched alcohol having 14 to 26 carbon atoms is in the range from 0.1 to 5.0%by weight, more preferably from 0.2 to 2.0%by weight and most preferably 0.3 to 1.8%by weight, calculated to the total weight of the composition.
  • the total quantity of the at least one further branched alcohol having 16 to 24 carbon atoms is in the range from 0.1 to 5.0%by weight, more preferably from 0.2 to 2.0%by weight and most preferably 0.3 to 1.8%by weight, calculated to the total weight of the composition.
  • the total quantity of the at least one further branched alcohol having 18 to 22 carbon atoms is in the range from 0.1 to 5.0%by weight, more preferably from 0.2 to 2.0%by weight and most preferably 0.3 to 1.8%by weight, calculated to the total weight of the composition.
  • the total quantity of the at least one further branched alcohol having 20 carbon atoms is in the range from 0.1 to 5.0%by weight, more preferably from 0.2 to 2.0%by weight and most preferably 0.3 to 1.8%by weight, calculated to the total weight of the composition.
  • Preferred examples of those alcohols are octyldodecanol and/or hexyldecanol. Most preferred is octyldodecanol.
  • Preferred embodiments of the invention are characterized in that the total quantity of the alcohols selected from the group consisting of octyldodecanol and/or hexyldecanol is in the range from 0.1 to 5.0%by weight, more preferably from 0.2 to 2.0%by weight and most preferably 0.3 to 1.8%by weight, calculated to the total weight of the composition.
  • the composition comprises further oil compounds with the exception of silicone oils.
  • the further oil compounds may be selected from further natural or synthetic oils.
  • One oil which may be contained according to the invention is chosen from the esters of the linear or branched saturated or unsaturated fatty alcohols having 2-30 carbon atoms with linear or branched saturated or unsaturated fatty acids having 2-30 carbon atoms, which may be hydroxylated.
  • Preferred esters of the linear or branched saturated or unsaturated fatty alcohols having 2-30 carbon atoms with linear or branched saturated or unsaturated fatty acids having 2-30 carbon atoms, which may be hydroxylated are selected from the group consisting of hexyldecyl stearate, hexyldecyl laurate, isodecyl neopentanoate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl stearate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl isostearate, isopropyl oleate, isooctyl stearate, isononyl stearate, isocetyl stearate, isononyl isononanoate, isotridecyl isononanoate, cetearyl
  • At least one fatty acid triglyceride is contained in the composition. It is preferred if the fatty acid triglyceride is selected from Cocos Nucifera Oil (Triglyceride (Fractionated Coconut Oil) ) , Astrocaryum Murumuru Seed Butter (Astrocaryum sp Triglycerides) , C10-18 Triglycerides, C10-40 Isoalkyl Acid Triglyceride, C12-18 Acid Triglyceride, C18-36 Acid Triglyceride, C8-12 Acid Triglyceride, Caprylic/capric/myristic/stearic Triglyceride, Caprylic/Capric Triglyceride, Capric/Lauric/Myristic/Oleic Triglyceride, Caprylic/Capric/Linoleic Triglyceride, Caprylic/Capric/Stearic Triglyceride, Castoryl Maleate (Ceraphyl RMT (Ricinoleyl Mono
  • the fatty acid triglyceride can also be part of natural oils.
  • Preferred natural oils which can be contained are coconut oil, (sweet) almond oil, walnut oil, peach kernel oil, apricot kernel oil, avocado oil, tea tree oil, soybean oil, glycine soja oil, sesame oil, sunflower oil, tsubaki oil, evening primrose oil, rice bran oil, palm kernel oil, mango kernel oil, cuckoo flower oil, thistle oil, macadamia nut oil, grape seed oil, amaranth seed oil, argan oil, bamboo oil, olive oil, wheat germ oil, pumpkin seed oil, mallow oil, hazelnut oil, safflower oil, canola oil, sasanqua oil, jojoba oil, rambutan oil, cocoa butter, and shea butter.
  • Further compounds which can be contained in the oil phase are for example chosen from further branched saturated or unsaturated fatty alcohols having 6-30 carbon atoms. These alcohols are also often referred to as Guerbet alcohols since they are obtainable according to the Guerbet reaction.
  • Preferred alcohol oils are hexyldecanol ( G 16, T 16) , octyldodecanol ( G, 20) and 2-ethylhexyl alcohol.
  • oils preferred according to the invention are chosen from the addition products of from 1 to 5 propylene oxide units onto mono-or polyhydric C8-22-alkanols, such as octanol, decanol, decanediol, lauryl alcohol, myristyl alcohol and stearyl alcohol, e.g., PPG-2 myristyl ether and PPG-3 myristyl ether ( APM) .
  • mono-or polyhydric C8-22-alkanols such as octanol, decanol, decanediol, lauryl alcohol, myristyl alcohol and stearyl alcohol, e.g., PPG-2 myristyl ether and PPG-3 myristyl ether ( APM) .
  • oils which can be contained in the composition according to the invention are chosen from the addition products of at least 6 ethylene oxide and/or propylene oxide units onto mono-or polyhydric C3-2 2-alkanols, such as butanol, butanediol, myristyl alcohol and stearyl alcohol, e.g., PPG-14 butyl ether (Ucon AP) , PPG-9 butyl ether ( B25) , PPG-10 butanediol ( 57) and PPG-15 stearyl ether ( E) .
  • PPG-14 butyl ether Ucon AP
  • PPG-9 butyl ether B25
  • PPG-10 butanediol 57
  • PPG-15 stearyl ether E
  • Further oils are preferably chosen from the C8-C22-fatty alcohol esters of monobasic or polybasic C2-C7-hydroxycarboxylic acids, in particular, the esters of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid and salicylic acid.
  • esters based on linear C14/15-alkanols, e.g., C12-C15-alkyl lactate, and on C12/13-alkanols branched in the 2 position are available under the trade name from Nordmann, Rassmann GmbH &Co., Hamburg, in particular the commercial products ESI, EMI and ETI.
  • oils which can preferably be used are chosen from the symmetrical, asymmetrical or cyclic esters of carbonic acid with fatty alcohols, e.g., glycerol carbonate, dicaprylyl carbonate ( CC) or the esters of DE 197 56 454 A1.
  • the composition comprises at least one fatty alcohol comprising 12 to 22 carbon atoms.
  • fatty alcohols cetyl alcohol, stearyl alcohol and the corresponding mixture cetearyl alcohol are most preferred.
  • Preferred embodiments of the invention are further preferably characterized in that at least one polysaccharide is contained as structuring agent for the composition. According to the invention it is preferred if the polysaccharide is a gum.
  • Preferred gums which can be used according to the invention are selected from the group of xanthan gum, gellan gum, sclerotium gum and dehydroxanthan gum.
  • the composition comprises 0.1 to 1.5%by weight, more preferably 0.15 to 1.0 %by weight and most preferably 0.3 to 0.8%by weight of at least one polymer selected from the group of xanthan gum, gellan gum, sclerotium gum and dehydroxanthan gum, calculated to the total weight of the composition. It is particular preferred if xanthan gum is contained and the total quantity of xanthan gum is in the range from 0.1 to 1.5%by weight, more preferably 0.15 to 1.0 %by weight and most preferably 0.3 to 0.8%by weight, calculated to the total weight of the composition.
  • xanthan gum is contained. It is particular preferred if xanthan gum is contained in a total quantity ranging from 0.1 to 1.5%by weight, more preferably 0.15 to 1.0 %by weight and most preferably 0.3 to 0.8%by weight calculated to the total weight of the composition.
  • compositions of the invention comprise hydroxypropyl starch phosphate.
  • hydroxypropyl starch phosphate is contained, it is preferred if the total quantity of hydroxypropyl starch phosphate is in the range from 0.01 to 2.5%by weight, more preferably 0.4 to 2.4%by weight and most preferably 0.5 to 1.9%by weight calculated to the total weight of the composition.
  • the composition is characterized in that it is an emulsion. It is preferred if it is an oil in water emulsion.
  • composition of the invention may preferentially further comprises an emulsifier system to further stabilize the oil phase and avoid an oil separation.
  • the composition comprises at least one polyglyceryl ester as emulsifer.
  • Polyglyceryl esters are understood as an ester formed from polyglycerol (for example polyglycerol-10) and at least one mono-or polyvalent fatty acid.
  • the total quantity of the polyglyceryl ester is in the range from 0.1 to 2.0%by weight, more preferably 0.3 to 1.5%by weight and most preferably 0.5 to 1.0%by weight, calculated to the total weight of the composition.
  • the one or more polyglyceryl esters are selected from esters made of a polyglycerin containing 5 to 15 subunits and a monovalent fatty acid comprising 16 to 20 carbon atoms. It is more preferred if the one or more polyglyceryl esters are selected from esters made of a polyglycerin containing 7 to 12 subunits and a monovalent fatty acid comprising 16 to 20 carbon atoms.
  • the one or more polyglycerylester is selected from the group consisting of polyglyceryl-10 dimyristate, polyglyceryl-10 diisostearate, polyglyceryl-10 distearate, polyglyceryl-10 dioleate, polyglyceryl-10 dilaurate, polyglyceryl-10 dipalmitate, polyglyceryl-10 nonaisostearate, polyglyceryl-10 heptastearate, polyglyceryl-10 heptaoleate, polyglyceryl-10 myristate, polyglyceryl-10 tristearate, polyglyceryl-10 trioleate, polyglyceryl-10 behenate/eicosadioate, polyglyceryl-10 decaethylhexanoate, polyglyceryl-10 decamacadamiate, polyglyceryl-10 decaisostearate, polyglyceryl-10 decastearate, polyglyceryl-10 decaole
  • the composition comprises polyglyceryl-10 stearate, polyglyceryl-10 myristate, polyglyceryl-6 laurate, polyglyceryl-8 stearate and/or polyglyceryl-3 methylglucose distearate.
  • the total quantity of polyglyceryl-10 stearate, polyglyceryl-10 myristate, polyglyceryl-6 laurate, polyglyceryl-8 stearate and/or polyglyceryl-3 methylglucose distearate is in the range from 0.1 to 2.0%by weight, more preferably 0.3 to 1.5%by weight and most preferably 0.5 to 1.0%by weight, calculated to the total weight of the composition.
  • the total quantity of the polyglyceryl ester is in the range from 0.1 to 2.0%by weight, more preferably 0.3 to 1.5%by weight and most preferably 0.5 to 1.0%by weight, calculated to the total weight of the composition.
  • glyceryl stearate, glyceryl stearate SE, and/or sodium stearoyl glutamate are contained as emulsifier.
  • glyceryl stearate and/or glyceryl stearate SE are contained, it is preferred if the total quantity of those is in the range from 0.05 to 1.0%by weight, calculated to the total weight of the composition.
  • composition according to the invention comprises further short chain polyols comprising 2 to 8 carbon atoms.
  • Preferred polyols of that type are butylene glycol, glycerol, propylene glycol, pentylene glycol, butylene glycol, 1, 2 hexanediol, 1, 2 heptanediol, 1, 2 propanediol, methylpropanediol and caprylyl glycol.
  • those preferred polyols are contained in quantities ranging from 0.1 to 15%by weight, more preferably 1 to 9%by weight and most preferably from 1.5 to 8%by weight, calculated to the total weight of the composition.
  • pentylene glycol is contained.
  • the total quantity of pentylene glycol is in the range from 0.1 to 4.0%by weight, more preferably from 0.2 to 3.0%by weight and most preferably from 0.3 to 2.5%by weight, calculated to the total weight of the composition.
  • caprylyl glycol is contained, it is preferred if the total quantity of caprylyl glycol is in the range from 0.1 to 5%by weight, more preferably 0.2 to 2%by weight and most preferably from 0.3 to 1.5%by weight, calculated to the total weight of the composition.
  • glycerol is contained.
  • the total quantity of glycerol is in the range from 0.1 to 15.0%by weight, more preferably from 4.0 to 13.0%by weight and most preferably from 7.0 to 12%by weight, calculated to the total weight of the composition.
  • composition comprises phenoxyethanol, hydroxacetophenone and/or ethylhexylglycerin.
  • phenoxyethanol is contained it is preferred if the total quantity of phenoxyethanol is in the range from 0.1 to 0.8%by weight, calculated to the total weight of the composition.
  • ethylhexylglycerin is contained it is preferred if the total quantity of ethylhexylglycerin is in the range from 0.1 to 1.2%by weight, calculated to the total weight of the composition.
  • hydroxacetophenone is contained it is preferred if the total quantity of hydroxacetophenone is in the range from 0.1 to 0.5%by weight, calculated to the total weight of the composition.
  • water is contained in the composition in a total quantity ranging from 75.0%by weight to 95%by weight, e.g., 80%by weight, 85%by weight, or 90%by weight, calculated to the total weight of the composition.
  • the composition has a viscosity ranging from 300 to 1000 mPa ⁇ s.
  • active ingredients are contained. These are advantageously selected from the group containing sodium hyaluronate, 1-methylhydantoin-2-imide, creatine, folic acid, panthenol, pantolactone, vitamin C, magnolia, calcium pantothenate and sodium ascorbyl phosphate.
  • the active ingredients mentioned in the group are advantageously used in total proportions of up to 10%by weight, preferably less than 1%by weight, based on the total weight of the composition.
  • compositions according to the invention may further comprise ingredients commonly used in the compositions of this type.
  • Examples 1 is a composition according to the invention.
  • the further examples Ex. 2 and Ex. 3 are reference examples not in scope of the invention.
  • the pilling test was performed by a well-trained pilling panel with around 30 panelists, and each sample will be tested twice.
  • Panelists wash their hands and arms with a standard cleanser, after drying, apply 0.1g toner until completely absorbed.
  • the pilling percentage Number of pilling cases/total test panelist number *100%.

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne et présentant un effet de boulochage réduit.
PCT/CN2023/124938 2023-10-17 2023-10-17 Produit cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne Pending WO2025081336A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/CN2023/124938 WO2025081336A1 (fr) 2023-10-17 2023-10-17 Produit cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne
PCT/EP2024/079018 WO2025082967A1 (fr) 2023-10-17 2024-10-15 Produit cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne
CN202411452536.7A CN119837773A (zh) 2023-10-17 2024-10-17 含4-叔丁基环己醇和依克多因的化妆品

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2023/124938 WO2025081336A1 (fr) 2023-10-17 2023-10-17 Produit cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne

Publications (1)

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WO2025081336A1 true WO2025081336A1 (fr) 2025-04-24

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PCT/CN2023/124938 Pending WO2025081336A1 (fr) 2023-10-17 2023-10-17 Produit cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne
PCT/EP2024/079018 Pending WO2025082967A1 (fr) 2023-10-17 2024-10-15 Produit cosmétique contenant du 4-t-butylcyclohexanol et de l'ectoïne

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