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WO2025078793A1 - Système de bobine de stimulation magnétique - Google Patents

Système de bobine de stimulation magnétique Download PDF

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Publication number
WO2025078793A1
WO2025078793A1 PCT/GB2024/052517 GB2024052517W WO2025078793A1 WO 2025078793 A1 WO2025078793 A1 WO 2025078793A1 GB 2024052517 W GB2024052517 W GB 2024052517W WO 2025078793 A1 WO2025078793 A1 WO 2025078793A1
Authority
WO
WIPO (PCT)
Prior art keywords
winding
coil
adaptor
current flow
coil system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/GB2024/052517
Other languages
English (en)
Inventor
Majid MEMARIAN SORKHABI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Magstim Co Ltd
Original Assignee
Magstim Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magstim Co Ltd filed Critical Magstim Co Ltd
Publication of WO2025078793A1 publication Critical patent/WO2025078793A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F5/00—Coils
    • H01F5/04—Arrangements of electric connections to coils, e.g. leads

Definitions

  • the present invention relates to the field of Magnetic Stimulation (MS), and preferably Transcranial Magnetic Stimulation (TMS).
  • MS Magnetic Stimulation
  • TMS Transcranial Magnetic Stimulation
  • Magnetic stimulating of neuromuscular tissue comprises a stimulating coil made up of one or more windings, each having a plurality of turns which may generate a succession of electrical discharge pulses producing magnetic pulses which further induce electrical signals in the tissue.
  • the magnetic stimulator generally comprises a charging circuit, a capacitor, a discharge control and a winding which is of a size and power rating appropriate for the generation of magnetic fields sufficient to cause neuromodulation of a body portion.
  • the individual winding or plurality of windings may be size adapted to fit partly over the cranium of a human patient in many applications, as well as being used for stimulation of other body parts.
  • a Magnetic Stimulation (MS) coil system for connection to a current pulse generator, the MS coil system comprising: at least one coil winding for delivering a magnetic field to a target zone of a body; a first and second adaptor for providing a current pathway from the stimulator to the at least one coil winding for delivering current pulses to the at least one coil winding, the first and second adaptors being releasably engageable between a stimulator and the at least one coil winding independently of one another;
  • the first direction may be clockwise and the second direction may be anticlockwise, wherein the second adaptor may be arranged to engage with the first winding such that the current flow direction in the first winding is in the anticlockwise direction, and the second adaptor is arranged to engage with the second winding such that the current flow direction in the second winding is in the clockwise direction.
  • This set-up enables operation in a normal treatment mode however allows for alternate flow direction and therefore enables switching between posterior to anterior (PA) and anterior to posterior (AP) pulse waveforms. This is useful for recording differences in latency responses where research has shown that latency exceeding a predetermined threshold is indicative of certain conditions, for example Alzheimer’s.
  • the first and second adaptor each preferably define a current pathway from: a first terminal from a stimulator to a second terminal connected to the first winding; a third terminal from the first winding to a fourth terminal to the second winding; a fifth terminal from the second winding to a sixth terminal to a stimulator.
  • the second, third, fourth and fifth terminal of the first and second adaptors may comprise sockets. These terminals may be configured such that it is impermissible to incorrectly connect the winding(s) to the adaptor due, for example, to specific engagement formations for each terminal and/or specific markings. This enables ease of switching between different adaptors.
  • the MS coil system preferably comprises a Transcranial Magnetic Stimulation (TMS) system.
  • TMS Transcranial Magnetic Stimulation
  • Figure 1 shows a schematic perspective view of a known coil arrangement represented in two forms wherein Figure la also shows the direction of current flow through the two windings and Figure lb shows the conductive element that connects to a MS stimulator.
  • first and second windings 4,6 may be termed left 4 and right 6 hand coil windings for clarity purposes.
  • an adaptor 16 Intermediate the stimulator 3 and the windings 4,6 is an adaptor 16. Arrows again indicate the current flow directions in the four different embodiments.
  • Each of the adaptors 16a-d presented in Figures 3a-d connect to the stimulator in the same way as the adaptors presented in Figure 2, however in these embodiments there are four connections to the two windings required.
  • FIG. 3a enhanced stimulation in a target zone is enabled through the provision of adaptor 16a and the current flow pathways enabled by this adaptor.
  • the current flow around the windings must be generally aligned at a location intermediate the two windings 4,6. This can be seen in Figure 3a where the current flow around the first and second windings 4,6 is in opposite directions (clockwise and anticlockwise) respectively.
  • the adaptor 16a defines a current pathway from the first terminal 28 from the stimulator 3 to a second terminal 20 connected to the first winding 4, a third terminal 22 from the first winding to a fourth terminal 32 to the second winding 6 and a fifth terminal 34 from the second winding 6 to a sixth terminal 29 to a stimulator.
  • the adaptor 16b is designed to provide current flow pathways therethrough showing the terminals using the same reference numerals as used in Figure 3a that means the magnetic fields generated by each of the first and second windings 4,6 are at least partially cancelled meaning the coil can be used in a sham or placebo mode of operation.
  • the current flow direction around the windings is the same (i.e. in this embodiment both are clockwise) meaning in the zone intermediate the two windings 4,6 the magnetic fields are cancelled to a degree that there is no treatment to a patient, rather they feel scalp stimulation in the same way as is achieved through a normal treatment which would be achieved using the embodiments of Figures 3a and c. This effect is demonstrated by Figure 4b.
  • this MS coil system can be compared to the MS coil system of Figure 3a as also providing a treatment or combined magnetic field when current is supplied through the windings simultaneously.
  • the current pathways are presented showing the terminals using the same reference numerals as used in Figure 3a. This is different to that of Figure 3a however as the current flow through the left-hand winding 4 is the opposite direction to that of the same right-hand coil winding 6 of Figure 3a, and the current flow direction through the right-hand coil 6 winding of Figure 3c is the opposite to that of the same right-hand coil winding 6 of Figure 3a.
  • the different effect achieved can again be described with respect to Figure 6 and allows switching between posterior to anterior (PA) and anterior to posterior (AP) pulse waveforms.
  • PA posterior to anterior
  • AP anterior to posterior
  • Figure 4a and 4b display the computational modelling of two operable modes, corresponding to Figure 3a and Figure 3b, respectively.
  • the E-field profile resembles that of conventional ‘figure-of-eight’ coils.
  • Figure 4b it is evident that the E-fields of the two windings 4 and 6 attenuate each other in the central region, resulting in minimal stimulation.
  • an induced field is visible.
  • the head model 40 was assumed to consist of homogeneous tissue.
  • FIG. 5 a schematic representation is made of a MS coil as described with respect to any of the Figures and for illustrative purposes only presents a double coil winding.
  • the windings 4,6 are incorporated into a cap 42 to be worn by the test subject.
  • the coil windings may be moveable relative to the cap between multiple operable configurations to allow treatment at multiple locations without reorientation of the cap 42 itself.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Magnetic Treatment Devices (AREA)

Abstract

L'invention concerne un système de bobine de stimulation magnétique (MS) destiné à être connecté à un générateur d'impulsions de courant. Le système de bobine MS comprend : - au moins un enroulement de bobine pour délivrer un champ magnétique à une zone cible d'un corps ; - un premier et un second adaptateur pour fournir un trajet de courant du stimulateur vers l'au moins un enroulement de bobine pour délivrer des impulsions de courant à l'au moins un enroulement de bobine, les premier et second adaptateurs pouvant venir en prise de manière libérable entre un stimulateur et l'au moins un enroulement de bobine indépendamment l'un de l'autre ; - le premier adaptateur étant conçu pour permettre une circulation de courant dans une première direction autour de l'enroulement de bobine, et le second adaptateur étant conçu pour permettre une circulation de courant dans une seconde direction opposée autour de l'enroulement de bobine.
PCT/GB2024/052517 2023-10-09 2024-10-01 Système de bobine de stimulation magnétique Pending WO2025078793A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2315456.0 2023-10-09
GB2315456.0A GB2634713A (en) 2023-10-09 2023-10-09 Magnetic stimulation coil system

Publications (1)

Publication Number Publication Date
WO2025078793A1 true WO2025078793A1 (fr) 2025-04-17

Family

ID=93100880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2024/052517 Pending WO2025078793A1 (fr) 2023-10-09 2024-10-01 Système de bobine de stimulation magnétique

Country Status (2)

Country Link
GB (1) GB2634713A (fr)
WO (1) WO2025078793A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200498115Y1 (ko) 2020-05-04 2024-07-03 비티엘 헬쓰케어 테크놀로지스 에이.에스. 환자의 미용 시술을 위한 디바이스

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179770B1 (en) 1998-04-25 2001-01-30 Magstim Company Limited Coil assemblies for magnetic stimulators
US20050113635A1 (en) * 2000-09-08 2005-05-26 Converge Medical, Inc. Heart support to prevent ventricular remodeling
GB2534369A (en) * 2015-01-20 2016-07-27 The Magstim Company Ltd Magnetic field shielding arrangement for a magnetic stimulation (MS) coil
US20180078780A1 (en) * 2016-09-20 2018-03-22 Rhode Island Board Of Education, State Of Rhode Island And Providence Plantations Time-Varying Magnetic Field Therapy Using Multistable Latching Mechanisms
US20200353274A1 (en) * 2019-05-06 2020-11-12 Kamran Ansari Systems and Methods of Treating Medical Conditions Using Arrays of Planar Coils Configured to Generate Pulsed Electromagnetic Fields and Integrated into Clothing
EP3166685B1 (fr) * 2014-07-07 2021-04-14 The Magstim Company Limited Dispositif de bobine pour stimulation magnétique
US20210346711A1 (en) * 2019-05-06 2021-11-11 Kamran Ansari Systems and Methods of Modulating Functionality of an Animal Brain Using Arrays of Planar Coils Configured to Generate Pulsed Electromagnetic Fields and Integrated into Headwear
CN113764184A (zh) * 2021-09-07 2021-12-07 深圳英智科技有限公司 一种储能电容充电极性更换装置和经颅刺激装置
US20220190527A1 (en) * 2020-12-15 2022-06-16 Teradyne, Inc. Interposer
US20230104434A1 (en) * 2019-05-06 2023-04-06 Kamran Ansari Pulsed Electromagnetic Field Devices Integrated into Adjustable Clothing

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11666775B2 (en) * 2018-03-29 2023-06-06 Minnesota Medical Physics Llc Method and apparatus for treatment of benign prostatic hyperplasia (BPH)

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179770B1 (en) 1998-04-25 2001-01-30 Magstim Company Limited Coil assemblies for magnetic stimulators
US20050113635A1 (en) * 2000-09-08 2005-05-26 Converge Medical, Inc. Heart support to prevent ventricular remodeling
EP3166685B1 (fr) * 2014-07-07 2021-04-14 The Magstim Company Limited Dispositif de bobine pour stimulation magnétique
GB2534369A (en) * 2015-01-20 2016-07-27 The Magstim Company Ltd Magnetic field shielding arrangement for a magnetic stimulation (MS) coil
US20180078780A1 (en) * 2016-09-20 2018-03-22 Rhode Island Board Of Education, State Of Rhode Island And Providence Plantations Time-Varying Magnetic Field Therapy Using Multistable Latching Mechanisms
US20200353274A1 (en) * 2019-05-06 2020-11-12 Kamran Ansari Systems and Methods of Treating Medical Conditions Using Arrays of Planar Coils Configured to Generate Pulsed Electromagnetic Fields and Integrated into Clothing
US20210346711A1 (en) * 2019-05-06 2021-11-11 Kamran Ansari Systems and Methods of Modulating Functionality of an Animal Brain Using Arrays of Planar Coils Configured to Generate Pulsed Electromagnetic Fields and Integrated into Headwear
US20230104434A1 (en) * 2019-05-06 2023-04-06 Kamran Ansari Pulsed Electromagnetic Field Devices Integrated into Adjustable Clothing
US20220190527A1 (en) * 2020-12-15 2022-06-16 Teradyne, Inc. Interposer
CN113764184A (zh) * 2021-09-07 2021-12-07 深圳英智科技有限公司 一种储能电容充电极性更换装置和经颅刺激装置

Also Published As

Publication number Publication date
GB2634713A (en) 2025-04-23

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