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WO2025078559A3 - Respiratory microbiome signatures - Google Patents

Respiratory microbiome signatures Download PDF

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Publication number
WO2025078559A3
WO2025078559A3 PCT/EP2024/078627 EP2024078627W WO2025078559A3 WO 2025078559 A3 WO2025078559 A3 WO 2025078559A3 EP 2024078627 W EP2024078627 W EP 2024078627W WO 2025078559 A3 WO2025078559 A3 WO 2025078559A3
Authority
WO
WIPO (PCT)
Prior art keywords
respiratory
respiratory microbiome
microbiome signatures
signatures
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/078627
Other languages
French (fr)
Other versions
WO2025078559A2 (en
Inventor
Antoine ROQUILLY
Emmanuel MONTASSIER
Lise CREMET
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Nantes
Institut National de la Sante et de la Recherche Medicale INSERM
Centre Hospitalier Universitaire de Nantes
Original Assignee
Universite de Nantes
Institut National de la Sante et de la Recherche Medicale INSERM
Centre Hospitalier Universitaire de Nantes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Nantes, Institut National de la Sante et de la Recherche Medicale INSERM, Centre Hospitalier Universitaire de Nantes filed Critical Universite de Nantes
Publication of WO2025078559A2 publication Critical patent/WO2025078559A2/en
Publication of WO2025078559A3 publication Critical patent/WO2025078559A3/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a method for determining a risk of having or developing a respiratory condition in a subject, based on the detection of the presence or abundance of bacteria of specific genus in a respiratory sample of said subject.
PCT/EP2024/078627 2023-10-13 2024-10-11 Respiratory microbiome signatures Pending WO2025078559A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23306796 2023-10-13
EP23306796.6 2023-10-13

Publications (2)

Publication Number Publication Date
WO2025078559A2 WO2025078559A2 (en) 2025-04-17
WO2025078559A3 true WO2025078559A3 (en) 2025-05-22

Family

ID=88793271

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/078627 Pending WO2025078559A2 (en) 2023-10-13 2024-10-11 Respiratory microbiome signatures

Country Status (1)

Country Link
WO (1) WO2025078559A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210107412A (en) * 2020-02-24 2021-09-01 한림대학교 산학협력단 Predicting Method for Extubation Success Rate and 28-day Survival Rate by Respiratory Microbiota Profiling of Mechanically Ventilated Patients
WO2021195236A1 (en) * 2020-03-24 2021-09-30 Microbion Corporation Bismuth thiol compounds and compositions and methods of treating microbial co-infections
WO2021202523A1 (en) * 2020-03-31 2021-10-07 Applied Therapeutics, Inc. Aldose reductase inhibitors for the treatment of acute respiratory distress syndrome, acute lung inflammation/injury, cardiac injury and anti-viral therapy
CN114606308A (en) * 2022-01-26 2022-06-10 江门市中心医院 Prognostic and therapeutic markers for sepsis ARDS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210107412A (en) * 2020-02-24 2021-09-01 한림대학교 산학협력단 Predicting Method for Extubation Success Rate and 28-day Survival Rate by Respiratory Microbiota Profiling of Mechanically Ventilated Patients
WO2021195236A1 (en) * 2020-03-24 2021-09-30 Microbion Corporation Bismuth thiol compounds and compositions and methods of treating microbial co-infections
WO2021202523A1 (en) * 2020-03-31 2021-10-07 Applied Therapeutics, Inc. Aldose reductase inhibitors for the treatment of acute respiratory distress syndrome, acute lung inflammation/injury, cardiac injury and anti-viral therapy
CN114606308A (en) * 2022-01-26 2022-06-10 江门市中心医院 Prognostic and therapeutic markers for sepsis ARDS

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ALEXA A. PRAGMAN ET AL: "The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease", PLOS ONE, vol. 7, no. 10, 11 October 2012 (2012-10-11), pages e47305, XP055538254, DOI: 10.1371/journal.pone.0047305 *
FROMENTIN M�LANIE ET AL: "Lung Microbiome in Critically Ill Patients", LIFE, vol. 12, no. 1, 21 December 2021 (2021-12-21), CH, pages 7, XP093145250, ISSN: 2075-1729, DOI: 10.3390/life12010007 *
HERN�NDEZ-TER�N ALEJANDRA ET AL: "Dysbiosis and structural disruption of the respiratory microbiota in COVID-19 patients with severe and fatal outcomes", SCIENTIFIC REPORTS, vol. 11, no. 1, 29 October 2021 (2021-10-29), US, XP093266925, ISSN: 2045-2322, Retrieved from the Internet <URL:https://www.nature.com/articles/s41598-021-00851-0> DOI: 10.1038/s41598-021-00851-0 *
KITSIOS GEORGIOS D. ET AL: "Respiratory Tract Dysbiosis Is Associated with Worse Outcomes in Mechanically Ventilated Patients", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 202, no. 12, 15 December 2020 (2020-12-15), US, pages 1666 - 1677, XP093145089, ISSN: 1073-449X, DOI: 10.1164/rccm.201912-2441OC *
MAHMOODPOOR ATA ET AL: "Effect of a Probiotic Preparation on Ventilator-Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double-Blind Randomized Controlled Trial", NUTRITION IN CLINICAL PRACTICE, vol. 34, no. 1, 8 August 2018 (2018-08-08), US, pages 156 - 162, XP093266734, ISSN: 0884-5336, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fncp.10191> DOI: 10.1002/ncp.10191 *
MINMIN SU ET AL: "Probiotics for the Prevention of Ventilator-Associated Pneumonia: A Meta-Analysis of Randomized Controlled Trials", RESPIRATORY CARE, vol. 65, no. 5, 3 March 2020 (2020-03-03), US, pages 673 - 685, XP055757482, ISSN: 0020-1324, DOI: 10.4187/respcare.07097 *
MONTASSIER EMMANUEL ET AL: "Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia", vol. 29, no. 11, 1 November 2023 (2023-11-01), New York, pages 2793 - 2804, XP093144992, ISSN: 1078-8956, Retrieved from the Internet <URL:https://www.nature.com/articles/s41591-023-02617-9> DOI: 10.1038/s41591-023-02617-9 *
SHEN YIFEI ET AL: "Dynamic Alterations in the Respiratory Tract Microbiota of Patients with COVID-19 and its Association with Microbiota in the Gut", ADVANCED SCIENCE, vol. 9, no. 27, 3 July 2022 (2022-07-03), Germany, XP093266912, ISSN: 2198-3844, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full-xml/10.1002/advs.202200956> DOI: 10.1002/advs.202200956 *
SHILTS MEGHAN H. ET AL: "Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome", FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, vol. 11, 24 January 2022 (2022-01-24), XP055968200, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819187/pdf/fcimb-11-781968.pdf> DOI: 10.3389/fcimb.2021.781968 *
ZHANG PENG ET AL: "Pulmonary Microbial Composition in Sepsis-Induced Acute Respiratory Distress Syndrome", FRONTIERS IN MOLECULAR BIOSCIENCES, vol. 9, 23 June 2022 (2022-06-23), XP093145937, ISSN: 2296-889X, DOI: 10.3389/fmolb.2022.862570 *

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