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WO2025077900A1 - Moisturizing composition and use thereof - Google Patents

Moisturizing composition and use thereof Download PDF

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Publication number
WO2025077900A1
WO2025077900A1 PCT/CN2024/124544 CN2024124544W WO2025077900A1 WO 2025077900 A1 WO2025077900 A1 WO 2025077900A1 CN 2024124544 W CN2024124544 W CN 2024124544W WO 2025077900 A1 WO2025077900 A1 WO 2025077900A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
moisturizing
germ oil
moisturizing composition
lip balm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2024/124544
Other languages
French (fr)
Chinese (zh)
Inventor
孙怀庆
裴运林
蔡永通
郭朝万
聂艳峰
江川霞
李鑫宇
肖湲
席绍峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUANGZHOU QUALITY SUPERVISION AND TESTING INSTITUTE
Guangdong Marubi Biological Technology Co Ltd
Original Assignee
GUANGZHOU QUALITY SUPERVISION AND TESTING INSTITUTE
Guangdong Marubi Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GUANGZHOU QUALITY SUPERVISION AND TESTING INSTITUTE, Guangdong Marubi Biological Technology Co Ltd filed Critical GUANGZHOU QUALITY SUPERVISION AND TESTING INSTITUTE
Publication of WO2025077900A1 publication Critical patent/WO2025077900A1/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/927Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/001Preparations for care of the lips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

Definitions

  • the present invention belongs to the technical field of cosmetics, and in particular relates to a moisturizing composition and application thereof.
  • CN109875928A discloses a lip plumping lip balm and a preparation method thereof, comprising the following raw materials in parts by weight: olive squalane, jojoba esters, C10-30 acid cholesterol/lanosterol mixed ester, hydrogenated castor oil dimer linoleate, mineral oil, jojoba seed oil, meadowfoam seed oil, diisostearyl malate, isononyl isononanoate, phytosterol/octyldodecanol lauroyl glutamate, polyethylene, candelilla wax, polyglyceryl-2 triisostearate, beeswax, ozokerite, ceramide, tocopherol, a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, a fourth skin conditioning agent, and an antioxidant.
  • the lip plumping lip balm can make the lips fuller, smoother, and firmer, and is mild and non-irritating, and has no side effects on
  • CN112716846A discloses a jasmine hot spring lip balm with a repairing effect.
  • the jasmine hot spring lip balm with a repairing effect is made of the following raw materials in parts by weight: petrolatum, beeswax, PEG-50 shea butter, camellia seed oil, olive oil, jojoba seed oil, PEG-10 rapeseed sterol, mint Alcohol, tocopherol.
  • the present invention contains hot spring water and plant essences such as jasmine.
  • the hot spring water is drawn from the natural hot spring water in Fuzhou Shenjing.
  • the water is clear and transparent, rich in various minerals and trace elements, and has certain effects on beauty, whitening and skin repair.
  • the jasmine essence uses pure jasmine essence developed from jasmine flowers.
  • Other auxiliary materials include moisturizers, lubricants, skin conditioners, etc., which have moisturizing, soothing, repairing and other effects.
  • the avocado tree butter is a natural oil extracted from African shea nuts, rich in unsaturated fatty acids, and the natural moisturizing factor component therein is the same as the component extracted from the sebaceous glands, and is regarded as the most effective natural skin moisturizer;
  • the cocoa seed butter is a natural plant stearin in cocoa beans, which has a melting point close to that of human skin and is easily melted and absorbed, and is a good hydrating moisturizer;
  • the white beeswax can nourish and soften the skin;
  • the wheat germ oil has natural antioxidant, skin protection and anti-aging functions, and has strong moisturizing properties, can fade fine lines, increase skin moisturizing power, and can improve dry, dehydrated, aged, and wrinkled skin;
  • the rice germ oil can promote the production of cholesterol and ceramide in sebum and improve the softness of the skin;
  • the squalane is extracted from sugarcane, is easily absorbed, and is almost The same as the natural sebum of the skin, it maintains
  • the moisturizing composition comprises, by weight, 5-15 parts of avocado butter, 1-5 parts of cocoa seed butter, 1-5 parts of white beeswax, 5-15 parts of wheat germ oil, 5-15 parts of rice germ oil and 20-30 parts of squalane.
  • the amount of avocado tree butter added to the moisturizing composition of the present disclosure may be 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts;
  • the added amount of the cocoa seed butter can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts, etc.;
  • the amount of white beeswax added can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts, etc.;
  • the wheat germ oil may be added in an amount of 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts;
  • the rice germ oil may be added in an amount of 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts;
  • the added amount of squalane can be 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts or 29 parts, etc.
  • the moisturizing composition comprises, by weight, 8-12 parts of avocado butter, 2-4 parts of cocoa seed butter, 2-4 parts of white beeswax, 8-12 parts of wheat germ oil, 6-13 parts of rice germ oil and 22-28 parts of squalane.
  • the moisturizing composition further comprises fully human TM collagen.
  • the fully human TM collagen comprises: water, glycerol, sodium dihydrogen phosphate, Sodium, soluble collagen.
  • the added amount of the fully human TM collagen is 0.05-0.15 parts, for example, it can be 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, 0.1 parts, 0.11 parts, 0.12 parts, 0.13 parts or 0.14 parts, etc.
  • the cosmetics include lipstick, essence cream, face cream or face mask.
  • the mass percentage of the moisturizing composition in the cosmetic is 1-30%, for example, it can be 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%, 20%, 22%, 24%, 26% or 28%, etc. Specific point values within the above numerical ranges can be selected and will not be described one by one here.
  • the present disclosure provides a moisturizing lip balm, comprising the moisturizing composition according to the first aspect, caprylic/capric triglyceride and candelilla wax.
  • the added amount of the caprylic/capric triglyceride can be 52 parts, 54 parts, 56 parts, 58 parts, 60 parts, 62 parts, 64 parts, 66 parts or 68 parts, etc.;
  • the addition amount of the candelilla wax can be 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.
  • the moisturizing lip balm also includes plant extracts.
  • the plant extract comprises any one of rosemary extract, Laminaria japonica extract or tea extract, or a combination of at least two thereof.
  • rosemary extract is a natural antioxidant extracted from rosemary, which can inhibit reactive oxygen species (ROS) and free radicals; Laminaria japonica extract can reduce the expression of metalloproteinase (MMP1); tea extract can inhibit the expression of metalloproteinase (MMP3), and has good antioxidant effect.
  • ROS reactive oxygen species
  • MMP1 metalloproteinase
  • MMP3 metalloproteinase
  • the combination of the three has a synergistic effect in anti-oxidation, which can make the lipstick have good antioxidant effect, not only can inhibit lip pigmentation, but also can reduce lip wrinkles.
  • the mass ratio of the rosemary extract, the Laminaria japonica extract and the tea extract is (1-3):(1-2):(0.1-1).
  • 1-2 can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8 or 1.9, etc.;
  • “0.1-1” can be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 or 0.9, etc.
  • the present disclosure provides a method for preparing the moisturizing lip balm as described in the fourth aspect, wherein the method for preparing the moisturizing lip balm comprises stirring and mixing a moisturizing composition, oil and candelilla wax.
  • the temperature in step (1) is raised to 70-90°C, for example, 72°C, 75°C, 78°C, 80°C, 82°C, 85°C or 88°C.
  • the temperature in step (2) is lowered to 50-60°C, for example, 51°C, 53°C, 55°C, 57°C or 59°C.
  • the standing time in step (2) is 0.5-1 h, for example, 0.5 h, 0.6 h, 0.7 h, 0.8 h, 0.9 h or 1 h.
  • the rest of the raw materials can be used as long as they are purchased from regular dealers.
  • the present embodiment provides a moisturizing composition, which comprises, by weight, 10 parts of avocado butter, 2 parts of cocoa seed butter, 3 parts of white beeswax, 10 parts of wheat germ oil, 10 parts of rice germ oil, 25 parts of squalane, and 0.1 parts of fully human TM collagen.
  • the present embodiment provides a moisturizing composition, which comprises, by weight, 8 parts of avocado butter, 4 parts of cocoa seed butter, 2 parts of white beeswax, 12 parts of wheat germ oil, 6 parts of rice germ oil, 28 parts of squalane, and 0.13 parts of fully human TM collagen.
  • This comparative example provides a moisturizing composition, which differs from Example 1 only in that squalane is not included, and the reduced amount thereof is distributed to avocado butter, cocoa seed butter, white beeswax, wheat germ oil and rice germ oil in proportion to the number of parts, while the other components and the addition amounts remain unchanged.
  • This application example prepares a moisturizing lip balm, and its formula is: 30 parts of the moisturizing composition of Example 1, 8 parts of candelilla wax, and 62 parts of caprylic/capric triglyceride.
  • This application example provides three moisturizing lip balms, the formulas of which differ from those of application example 1 only in that the moisturizing composition of example 1 is replaced with the moisturizing compositions of examples 2-4 with the same addition amounts, and other conditions remain unchanged.
  • the preparation method refers to application example 1.
  • This application example provides a moisturizing lip balm, the formula of which is different from that of application example 5 only in that the plant extract does not contain Laminaria japonica extract, and the reduced amount thereof is distributed in proportion to the rosemary extract and In the tea extract, other components and contents remain unchanged.
  • the preparation method is referred to Application Example 1.
  • This application example provides a moisturizing lip balm, the formula of which is different from that of application example 5 only in that the plant extract does not contain tea extract, and the reduced amount thereof is distributed to rosemary extract and kelp extract in proportion, while the other ingredients and contents remain unchanged.
  • the preparation method is the same as that of application example 1.
  • This comparative application example provides six moisturizing lip balms, the formulas of which differ from those of Application Example 1 only in that the moisturizing composition of Example 1 is replaced by the moisturizing compositions of Comparative Examples 1-6 with the same addition amounts, and other conditions remain unchanged.
  • the preparation method refers to Application Example 1.
  • This comparative application example provides a moisturizing lip balm, the formula of which differs from that of Application Example 1 only in that the moisturizing composition of Example 1 is not included, and the reduced amount is supplemented by caprylic/capric triglyceride.
  • the preparation method refers to that of Application Example 1.
  • the acute oral toxicity test of cosmetics was carried out in accordance with the standard of acute oral toxicity test of chemicals GB/T21603 in this test example.
  • the red blood cell hemolysis test is one of the alternative methods for the rabbit eye irritation test (Draizetest).
  • the basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the amount of hemoglobin dissolved and the degree of denaturation.
  • the RBC test is mainly used internationally to evaluate the The eye irritation study of chemicals such as products and raw materials is carried out, and the classification standards are shown in Table 3 below.
  • the moisturizing lip balm disclosed in the present invention is safe and reliable, will not cause any side effects to the body, will not cause any adverse reactions, and will not bring any burden to the skin.
  • the data in Table 5 show that the lip balms prepared in Application Examples 1-3 have good moisturizing effects.
  • the skin moisture content can reach more than 68% at 0h, still more than 64% after 30min, and more than 59% after 60min.
  • Comparative Example 7 shows that after adding the moisturizing composition of the present disclosure, the lip balm can quickly moisturize the lip skin and lock the skin moisture.
  • Comparative Examples 1-6 show that the avocado tree butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane in the moisturizing composition cooperate with each other, have a synergistic effect, and have a significant moisturizing and synergistic effect.

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Abstract

Provided are a moisturizing composition and a use thereof. The moisturizing composition comprises shea butter, cocoa butter, white beeswax, wheat germ oil, oryza sativa germ oil, and squalane. All the components in the moisturizing composition are reasonable in compatibility and have a synergistic effect, so that the composition has a more excellent moisturizing effect; and all the components are natural plant components, are mild and safe, have no irritation to the skin, and conform to the green and environmentally-friendly trends in the cosmetics market, such that consumers can use the moisturizing composition more securely, , and the purchasing desire of the consumers is also improved.

Description

一种保湿组合物及其应用Moisturizing composition and application thereof

相关申请交叉引用Cross-reference to related applications

本公开要求于2023年10月12日向中国国家知识产权局提交的,标题为“一种保湿组合物及其应用”的申请号为202311326664.2的中国专利申请的优先权,该申请的全部内容通过引用并入本公开中。The present disclosure claims priority to Chinese patent application No. 202311326664.2 filed with the State Intellectual Property Office of China on October 12, 2023, entitled “A Moisturizing Composition and Its Application”, the entire contents of which are incorporated by reference into the present disclosure.

技术领域Technical Field

本公开属于化妆品技术领域,具体涉及一种保湿组合物及其应用。The present invention belongs to the technical field of cosmetics, and in particular relates to a moisturizing composition and application thereof.

背景技术Background Art

随着当下化妆品市场绿色环保的潮流趋势,消费者越来越青睐含有天然成分的产品,其中,唇膏也是如此,含有更多天然来源成分会更吸引消费者。同时,在产品中使用新技术制备的原料,有利于产品结合新科学技术,发挥期望的功效,从而占领更多的市场份额。With the current trend of green and environmental protection in the cosmetics market, consumers are increasingly favoring products containing natural ingredients, including lipsticks. Products containing more natural ingredients will be more attractive to consumers. At the same time, using raw materials prepared by new technologies in products is conducive to combining new science and technology with products to achieve the desired effects, thereby occupying more market share.

CN109875928A公开了一种丰唇润唇膏及其制备方法,包括按照重量份数计的如下原料:橄榄角鲨烷、霍霍巴酯类、C10-30酸胆甾醇/羊毛甾醇混合酯、氢化蓖麻油二聚亚油酸酯、矿油、霍霍巴籽油、白池花籽油、二异硬脂醇苹果酸酯、异壬酸异壬酯、植物甾醇/辛基十二醇月桂酰谷氨酸酯、聚乙烯、小烛树蜡、聚甘油-2三异硬脂酸酯、蜂蜡、地蜡、神经酰胺、生育酚、第一肌肤调理剂、第二肌肤调理剂、第三肌肤调理剂、第四肌肤调理剂、抗氧化剂。其能够使双唇更加丰盈饱满、光滑紧实,同时温和不刺激,对人体无副作用。CN109875928A discloses a lip plumping lip balm and a preparation method thereof, comprising the following raw materials in parts by weight: olive squalane, jojoba esters, C10-30 acid cholesterol/lanosterol mixed ester, hydrogenated castor oil dimer linoleate, mineral oil, jojoba seed oil, meadowfoam seed oil, diisostearyl malate, isononyl isononanoate, phytosterol/octyldodecanol lauroyl glutamate, polyethylene, candelilla wax, polyglyceryl-2 triisostearate, beeswax, ozokerite, ceramide, tocopherol, a first skin conditioning agent, a second skin conditioning agent, a third skin conditioning agent, a fourth skin conditioning agent, and an antioxidant. The lip plumping lip balm can make the lips fuller, smoother, and firmer, and is mild and non-irritating, and has no side effects on the human body.

CN112716846A公开了一种具有修复作用的茉莉温泉润唇膏,该具有修复作用的茉莉温泉润唇膏由包括如下重量份的原料制成:矿脂,蜂蜡,PEG-50牛油树脂,山茶籽油,油橄榄果油,霍霍巴籽油,PEG-10油菜籽甾醇,薄荷 醇,生育酚。本公开含有温泉水和茉莉花等植物精华。温泉水引自福州深井天然温泉水,水质清澈透明,富含多种矿物质和微量元素,对于美容美白、修复皮肤有一定的疗效,茉莉花精华使用茉莉鲜花研制出的纯茉莉精华,其他辅料有保湿剂、润滑剂、皮肤调理剂等,具有保湿、舒缓、修复等功效。CN112716846A discloses a jasmine hot spring lip balm with a repairing effect. The jasmine hot spring lip balm with a repairing effect is made of the following raw materials in parts by weight: petrolatum, beeswax, PEG-50 shea butter, camellia seed oil, olive oil, jojoba seed oil, PEG-10 rapeseed sterol, mint Alcohol, tocopherol. The present invention contains hot spring water and plant essences such as jasmine. The hot spring water is drawn from the natural hot spring water in Fuzhou Shenjing. The water is clear and transparent, rich in various minerals and trace elements, and has certain effects on beauty, whitening and skin repair. The jasmine essence uses pure jasmine essence developed from jasmine flowers. Other auxiliary materials include moisturizers, lubricants, skin conditioners, etc., which have moisturizing, soothing, repairing and other effects.

然而上述产品并没有考虑绿色环保因素,含有传统石油来源成分(如矿油矿脂),达不到理想的健康状态。基于此,结合绿色环保的市场趋势和近期行业的新技术,有必要开发一种绿色环保且具有保湿功效的产品以满足现代人们的需求。However, the above products do not take green environmental protection factors into consideration, contain traditional petroleum-derived ingredients (such as mineral oil and petrolatum), and cannot achieve ideal health conditions. Based on this, combined with the green environmental protection market trend and the recent new technologies in the industry, it is necessary to develop a green environmental protection and moisturizing product to meet the needs of modern people.

发明内容Summary of the invention

针对现有技术的不足,本公开的目的在于提供一种保湿组合物及其应用,所述保湿组合物选用天然来源成分来产生保湿功效,符合绿色环保潮流,且具有深层次补充水分的功效。In view of the deficiencies in the prior art, the present invention aims to provide a moisturizing composition and its application, wherein the moisturizing composition uses natural ingredients to produce moisturizing effects, conforms to the green environmental protection trend, and has the effect of deeply replenishing moisture.

为达到此发明目的,本公开采用以下技术方案:To achieve the purpose of this invention, the present invention adopts the following technical solutions:

第一方面,本公开提供了一种保湿组合物,所述保湿组合物包括牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷。In a first aspect, the present disclosure provides a moisturizing composition comprising avocado butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane.

本公开中,所述牛油果树果脂是从非洲乳木果仁中提炼的天然油脂,含有丰富的不饱和脂肪酸,其中的天然保湿因子成分和从皮脂腺中提取的成分相同,被视为最有效的天然皮肤保湿剂;所述可可籽脂是可可豆中的天然植物硬脂,熔点接近人体皮肤,极易被熔解吸收,是很好的水合保湿剂;所述白蜂蜡可起到滋养和柔软皮肤的作用;所述小麦胚芽油具有天然抗氧化、保护皮肤和抗皮肤老化的功能,其滋润性强,可淡化细纹,增加肌肤湿润力,可改善干燥、缺水、老化、皱纹肌肤;所述稻胚芽油可促进皮脂中的胆固醇和神经酰胺的生成,提高皮肤的柔润度;所述角鲨烷由甘蔗提取而来,容易吸收,几乎 与皮肤的天然皮脂相同,维持皮脂平衡,改善肌肤保护屏障,锁住水分,润泽保湿,减淡干纹,本公开的保湿组合物通过上述六种组分的搭配使用,六者协同增效,可使组合物具有更加优异的保湿效果。In the present disclosure, the avocado tree butter is a natural oil extracted from African shea nuts, rich in unsaturated fatty acids, and the natural moisturizing factor component therein is the same as the component extracted from the sebaceous glands, and is regarded as the most effective natural skin moisturizer; the cocoa seed butter is a natural plant stearin in cocoa beans, which has a melting point close to that of human skin and is easily melted and absorbed, and is a good hydrating moisturizer; the white beeswax can nourish and soften the skin; the wheat germ oil has natural antioxidant, skin protection and anti-aging functions, and has strong moisturizing properties, can fade fine lines, increase skin moisturizing power, and can improve dry, dehydrated, aged, and wrinkled skin; the rice germ oil can promote the production of cholesterol and ceramide in sebum and improve the softness of the skin; the squalane is extracted from sugarcane, is easily absorbed, and is almost The same as the natural sebum of the skin, it maintains sebum balance, improves the skin's protective barrier, locks in moisture, moisturizes and reduces dry lines. The moisturizing composition disclosed herein uses the above six components in combination, and the six components synergize to make the composition have a more excellent moisturizing effect.

优选地,所述保湿组合物按重量份数计包括牛油果树果脂5-15份、可可籽脂1-5份、白蜂蜡1-5份、小麦胚芽油5-15份、稻胚芽油5-15份和角鲨烷20-30份。Preferably, the moisturizing composition comprises, by weight, 5-15 parts of avocado butter, 1-5 parts of cocoa seed butter, 1-5 parts of white beeswax, 5-15 parts of wheat germ oil, 5-15 parts of rice germ oil and 20-30 parts of squalane.

本公开的保湿组合物中所述牛油果树果脂的添加量可以为6份、7份、8份、9份、10份、11份、12份、13份或14份;The amount of avocado tree butter added to the moisturizing composition of the present disclosure may be 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts;

所述可可籽脂的添加量可以为1份、1.5份、2份、2.5份、3份、3.5份、4份、4.5份或5份等;The added amount of the cocoa seed butter can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts, etc.;

所述白蜂蜡的添加量可以为1份、1.5份、2份、2.5份、3份、3.5份、4份、4.5份或5份等;The amount of white beeswax added can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts, etc.;

所述小麦胚芽油的添加量可以为6份、7份、8份、9份、10份、11份、12份、13份或14份;The wheat germ oil may be added in an amount of 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts;

所述稻胚芽油的添加量可以为6份、7份、8份、9份、10份、11份、12份、13份或14份;The rice germ oil may be added in an amount of 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts;

所述角鲨烷的添加量可以为21份、22份、23份、24份、25份、26份、27份、28份或29份等。The added amount of squalane can be 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts or 29 parts, etc.

优选地,所述保湿组合物按重量份数计包括牛油果树果脂8-12份、可可籽脂2-4份、白蜂蜡2-4份、小麦胚芽油8-12份、稻胚芽油6-13份和角鲨烷22-28份。Preferably, the moisturizing composition comprises, by weight, 8-12 parts of avocado butter, 2-4 parts of cocoa seed butter, 2-4 parts of white beeswax, 8-12 parts of wheat germ oil, 6-13 parts of rice germ oil and 22-28 parts of squalane.

优选地,所述保湿组合物还包括全人源TM胶原蛋白。Preferably, the moisturizing composition further comprises fully human TM collagen.

优选地,所述全人源TM胶原蛋白包括:水、甘油、磷酸二氢钠、磷酸氢二 钠、可溶性胶原。Preferably, the fully human TM collagen comprises: water, glycerol, sodium dihydrogen phosphate, Sodium, soluble collagen.

所述全人源TM胶原蛋白是以人胶原蛋白基因为模板,通过专利技术优化胶原蛋白的核苷酸序列,并通过分子生物学技术构建了重组胶原蛋白基因表达载体,在细胞中可溶性地表达了重组胶原蛋白。该胶原分子量小,具有极好的皮肤透过能力,同时具有很好的生物相容性和皮肤亲和性,容易被皮肤吸收利用。胶原蛋白中含有大量羧基和羟基的氨基酸,如羟脯氨酸、羟赖氨酸以及大量的甘氨酸等天然保湿因子,对皮肤具有很好的保湿效果。本公开的组合物中通过添加全人源TM胶原蛋白可使组合物的保湿效果更加优异。The fully human TM collagen is based on the human collagen gene as a template, and the nucleotide sequence of collagen is optimized by patented technology. The recombinant collagen gene expression vector is constructed by molecular biology technology, and the recombinant collagen is soluble in cells. The collagen has a small molecular weight and has excellent skin permeability. It also has good biocompatibility and skin affinity, and is easily absorbed and utilized by the skin. Collagen contains a large number of carboxyl and hydroxyl amino acids, such as hydroxyproline, hydroxylysine, and a large number of natural moisturizing factors such as glycine, which have a good moisturizing effect on the skin. By adding fully human TM collagen to the composition disclosed in the present invention, the moisturizing effect of the composition can be made even better.

优选地,所述全人源TM胶原蛋白的添加量为0.05-0.15份,例如可以为0.06份、0.07份、0.08份、0.09份、0.1份、0.11份、0.12份、0.13份或0.14份等。Preferably, the added amount of the fully human TM collagen is 0.05-0.15 parts, for example, it can be 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, 0.1 parts, 0.11 parts, 0.12 parts, 0.13 parts or 0.14 parts, etc.

上述各项数值范围内的具体点值均可选择,在此便不再一一赘述。Specific point values within the above numerical ranges can be selected and will not be described in detail here.

第二方面,本公开提供了一种如第一方面所述的保湿组合物在化妆品中的应用。In a second aspect, the present disclosure provides a use of the moisturizing composition according to the first aspect in cosmetics.

优选地,所述化妆品包括唇膏、精华霜、面霜或面膜。Preferably, the cosmetics include lipstick, essence cream, face cream or face mask.

优选地,所述保湿组合物在所述化妆品中的质量百分含量为1-30%,例如可以为2%、4%、6%、8%、10%、12%、14%、16%、18%、20%、22%、24%、26%或28%等,上述各项数值范围内的具体点值均可选择,在此便不再一一赘述。Preferably, the mass percentage of the moisturizing composition in the cosmetic is 1-30%, for example, it can be 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%, 20%, 22%, 24%, 26% or 28%, etc. Specific point values within the above numerical ranges can be selected and will not be described one by one here.

第三方面,本公开提供了一种保湿润唇膏,所述保湿润唇膏包括如第一方面所述的保湿组合物、辛酸/癸酸甘油三酯和小烛树蜡。In a third aspect, the present disclosure provides a moisturizing lip balm, comprising the moisturizing composition according to the first aspect, caprylic/capric triglyceride and candelilla wax.

本公开的唇膏的组分选择保湿组合物、辛酸/癸酸甘油三酯和小烛树蜡,各组分相互配合,涂上嘴唇后,可更快速地起到保湿效果,使得嘴唇更加光滑并具有滋润保湿等诸多功能。The components of the lipstick disclosed herein are selected from a moisturizing composition, caprylic/capric triglyceride and candelilla wax. The components cooperate with each other and can more quickly achieve a moisturizing effect after being applied on lips, making the lips smoother and having many functions such as moisturizing and hydrating.

优选地,所述保湿润唇膏按重量份数计包括如第一方面所述的保湿组合 物5-40份、辛酸/癸酸甘油三酯50-70份和小烛树蜡1-15份。Preferably, the moisturizing lip balm comprises the moisturizing combination as described in the first aspect in parts by weight. 5-40 parts of glycerol, 50-70 parts of caprylic/capric triglyceride and 1-15 parts of candelilla wax.

本公开的保湿润唇膏中所述保湿组合物的添加量可以为5份、8份、10份、12份、15份、18份、20份、22份、25份、28份、30份、32份、35份或38份等;The moisturizing composition in the moisturizing lip balm of the present disclosure may be added in an amount of 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 32 parts, 35 parts or 38 parts, etc.;

所述辛酸/癸酸甘油三酯的添加量可以为52份、54份、56份、58份、60份、62份、64份、66份或68份等;The added amount of the caprylic/capric triglyceride can be 52 parts, 54 parts, 56 parts, 58 parts, 60 parts, 62 parts, 64 parts, 66 parts or 68 parts, etc.;

所述小烛树蜡的添加量可以为6份、7份、8份、9份、10份、11份、12份、13份或14份。The addition amount of the candelilla wax can be 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

优选地,所述保湿润唇膏还包括有植物提取物。Preferably, the moisturizing lip balm also includes plant extracts.

优选地,所述植物提取物在所述保湿润唇膏中的质量百分含量为1-10%,例如可以为2%、3%、4%、5%、6%、7%、8%或9%等。Preferably, the mass percentage of the plant extract in the moisturizing lip balm is 1-10%, for example, it can be 2%, 3%, 4%, 5%, 6%, 7%, 8% or 9%.

优选地,所述植物提取物包括迷迭香提取物、楔基海带提取物或茶叶提取物中的任意一种或至少两种的组合。Preferably, the plant extract comprises any one of rosemary extract, Laminaria japonica extract or tea extract, or a combination of at least two thereof.

优选地,所述植物提取物包括迷迭香提取物、楔基海带提取物和茶叶提取物的组合。Preferably, the plant extract comprises a combination of rosemary extract, Laminaria japonica extract and tea extract.

本公开中,迷迭香提取物是从迷迭香中提取的一种天然抗氧化剂,可抑制活性氧(ROS)和自由基;楔基海带提取物可以降低金属蛋白酶(MMP1)的表达;茶叶提取物可抑制金属蛋白酶(MMP3)的表达,具有较好的抗氧化功效,三者搭配使用,在抗氧化方面具有协同增效的作用,可使所述唇膏具有较好的抗氧化功效,不仅可以抑制唇部色素沉淀,还能淡化唇部皱纹。In the present disclosure, rosemary extract is a natural antioxidant extracted from rosemary, which can inhibit reactive oxygen species (ROS) and free radicals; Laminaria japonica extract can reduce the expression of metalloproteinase (MMP1); tea extract can inhibit the expression of metalloproteinase (MMP3), and has good antioxidant effect. The combination of the three has a synergistic effect in anti-oxidation, which can make the lipstick have good antioxidant effect, not only can inhibit lip pigmentation, but also can reduce lip wrinkles.

优选地,所述迷迭香提取物、楔基海带提取物和茶叶提取物的质量比为(1-3):(1-2):(0.1-1)。Preferably, the mass ratio of the rosemary extract, the Laminaria japonica extract and the tea extract is (1-3):(1-2):(0.1-1).

其中“1-3”可以为1.2、1.4、1.5、1.6、1.8、2、2.2、2.4、2.5、2.6或2.8等; Wherein "1-3" can be 1.2, 1.4, 1.5, 1.6, 1.8, 2, 2.2, 2.4, 2.5, 2.6 or 2.8, etc.;

“1-2”可以为1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8或1.9等;"1-2" can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8 or 1.9, etc.;

“0.1-1”可以为0.2、0.3、0.4、0.5、0.6、0.7、0.8或0.9等。“0.1-1” can be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 or 0.9, etc.

上述各项数值范围内的具体点值均可选择,在此便不再一一赘述。Specific point values within the above numerical ranges can be selected and will not be described in detail here.

第四方面,本公开提供了一种如第四方面所述的保湿润唇膏的制备方法,所述保湿润唇膏的制备方法包括将保湿组合物、油脂和小烛树蜡搅拌混合后即得。In a fourth aspect, the present disclosure provides a method for preparing the moisturizing lip balm as described in the fourth aspect, wherein the method for preparing the moisturizing lip balm comprises stirring and mixing a moisturizing composition, oil and candelilla wax.

优选地,所述制备方法包括:Preferably, the preparation method comprises:

(1)将牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷混合后升温,然后加入辛酸/癸酸甘油三酯和小烛树蜡,混合均匀后保温;(1) mixing avocado butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane, heating the mixture, then adding caprylic/capric triglyceride and candelilla wax, mixing the mixture evenly and keeping the mixture warm;

(2)保温结束后依次加入全人源TM胶原蛋白和植物提取物,混合均匀后降温,静置后即得。(2) After the heat preservation is completed, add the fully human TM collagen and the plant extract in sequence, mix them evenly, cool them down, and let them stand to obtain the product.

优选地,步骤(1)所述升温至70-90℃,例如可以为72℃、75℃、78℃、80℃、82℃、85℃或88℃等。Preferably, the temperature in step (1) is raised to 70-90°C, for example, 72°C, 75°C, 78°C, 80°C, 82°C, 85°C or 88°C.

优选地,步骤(1)所述保温时间为8-20min,例如可以为9min、10min、11min、12min、13min、14min、15min、16min、17min、18min或19min等。Preferably, the insulation time in step (1) is 8-20 min, for example, it can be 9 min, 10 min, 11 min, 12 min, 13 min, 14 min, 15 min, 16 min, 17 min, 18 min or 19 min, etc.

优选地,步骤(2)所述降温至50-60℃,例如可以为51℃、53℃、55℃、57℃或59℃等。Preferably, the temperature in step (2) is lowered to 50-60°C, for example, 51°C, 53°C, 55°C, 57°C or 59°C.

优选地,步骤(2)所述静置时间为0.5-1h,例如可以为0.5h、0.6h、0.7h、0.8h、0.9h或1h等。Preferably, the standing time in step (2) is 0.5-1 h, for example, 0.5 h, 0.6 h, 0.7 h, 0.8 h, 0.9 h or 1 h.

上述各项数值范围内的具体点值均可选择,在此便不再一一赘述。Specific point values within the above numerical ranges can be selected and will not be described in detail here.

与现有技术相比,本公开具有如下有益效果:Compared with the prior art, the present invention has the following beneficial effects:

(1)本公开的保湿组合物中牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷各组分配伍合理,具有协同增效作用,可使组合物具 有更加优异的保湿效果。且各组分均为天然植物成分,温和安全,对皮肤无刺激,符合化妆品市场绿色环保潮流,不仅使消费者更安心的使用,还可以提高消费者的购买欲望。(1) The shea butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane in the moisturizing composition disclosed herein are reasonably formulated and have a synergistic effect, which can make the composition have It has a more excellent moisturizing effect. All components are natural plant ingredients, which are mild and safe, non-irritating to the skin, and conform to the green and environmental protection trend of the cosmetics market. It not only makes consumers feel more at ease when using it, but also increases consumers' desire to buy it.

(2)本公开的唇膏的组分选择保湿组合物、辛酸/癸酸甘油三酯和小烛树蜡,各组分相互配合,涂上嘴唇后,可更快速地起到保湿效果,使得嘴唇更加光滑并具有滋润保湿等诸多功能。(2) The components of the lipstick disclosed in the present invention include a moisturizing composition, caprylic/capric triglyceride and candelilla wax. The components cooperate with each other and can more quickly achieve a moisturizing effect after being applied to the lips, making the lips smoother and having many other functions such as moisturizing and hydrating.

具体实施方式DETAILED DESCRIPTION

为更进一步阐述本公开所采取的技术手段及其效果,以下结合本公开的优选实施例来进一步说明本公开的技术方案,但本公开并非局限在实施例范围内。In order to further explain the technical means and effects adopted by the present disclosure, the technical solution of the present disclosure is further explained below in combination with the preferred embodiments of the present disclosure, but the present disclosure is not limited to the scope of the embodiments.

下述实施例、对比例中所涉及的部分原料的规格信息如下:
The specifications of some raw materials involved in the following examples and comparative examples are as follows:

其余原料只要购买自正规经销商均可使用。The rest of the raw materials can be used as long as they are purchased from regular dealers.

实施例1 Example 1

本实施例提供一种保湿组合物,所述保湿组合物按重量份数计为牛油果树果脂10份、可可籽脂2份、白蜂蜡3份、小麦胚芽油10份、稻胚芽油10份、角鲨烷25份、全人源TM胶原蛋白0.1份。The present embodiment provides a moisturizing composition, which comprises, by weight, 10 parts of avocado butter, 2 parts of cocoa seed butter, 3 parts of white beeswax, 10 parts of wheat germ oil, 10 parts of rice germ oil, 25 parts of squalane, and 0.1 parts of fully human TM collagen.

实施例2Example 2

本实施例提供一种保湿组合物,所述保湿组合物按重量份数计为牛油果树果脂8份、可可籽脂4份、白蜂蜡2份、小麦胚芽油12份、稻胚芽油6份、角鲨烷28份、全人源TM胶原蛋白0.13份。The present embodiment provides a moisturizing composition, which comprises, by weight, 8 parts of avocado butter, 4 parts of cocoa seed butter, 2 parts of white beeswax, 12 parts of wheat germ oil, 6 parts of rice germ oil, 28 parts of squalane, and 0.13 parts of fully human TM collagen.

实施例3Example 3

本实施例提供一种保湿组合物,所述保湿组合物按重量份数计为牛油果树果脂12份、可可籽脂3份、白蜂蜡4份、小麦胚芽油8份、稻胚芽油13份、角鲨烷22份、全人源TM胶原蛋白0.08份。The present embodiment provides a moisturizing composition, which comprises, by weight, 12 parts of avocado butter, 3 parts of cocoa seed butter, 4 parts of white beeswax, 8 parts of wheat germ oil, 13 parts of rice germ oil, 22 parts of squalane, and 0.08 parts of fully human TM collagen.

实施例4Example 4

本实施例提供一种保湿组合物,所述保湿组合物与实施例1的区别仅在于不包括全人源TM胶原蛋白,其余组分及添加量不变。This embodiment provides a moisturizing composition. The moisturizing composition is different from that of Embodiment 1 only in that it does not include fully human TM collagen, and the other components and addition amounts remain unchanged.

对比例1Comparative Example 1

本对比例提供一种保湿组合物,所述保湿组合物与实施例1的区别仅在于不包括牛油果树果脂,其减少量按份数比例分配至可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷中,其余组分及添加量不变。This comparative example provides a moisturizing composition, which differs from Example 1 only in that avocado tree butter is not included, and the reduced amount thereof is distributed among cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane in proportion to the number of parts, while the other components and the addition amounts remain unchanged.

对比例2Comparative Example 2

本对比例提供一种保湿组合物,所述保湿组合物与实施例1的区别仅在于不包括可可籽脂,其减少量按份数比例分配至牛油果树果脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷中,其余组分及添加量不变。This comparative example provides a moisturizing composition, which differs from Example 1 only in that cocoa seed butter is not included, and the reduced amount thereof is distributed among avocado tree butter, white beeswax, wheat germ oil, rice germ oil and squalane in proportion to the number of parts, while the other components and the addition amounts remain unchanged.

对比例3 Comparative Example 3

本对比例提供一种保湿组合物,所述保湿组合物与实施例1的区别仅在于不包括白蜂蜡,其减少量按份数比例分配至牛油果树果脂、可可籽脂、小麦胚芽油、稻胚芽油和角鲨烷中,其余组分及添加量不变。This comparative example provides a moisturizing composition, which differs from Example 1 only in that white beeswax is not included, and the reduced amount thereof is distributed among avocado tree butter, cocoa seed butter, wheat germ oil, rice germ oil and squalane in proportion to the number of parts, while the other components and the addition amounts remain unchanged.

对比例4Comparative Example 4

本对比例提供一种保湿组合物,所述保湿组合物与实施例1的区别仅在于不包括小麦胚芽油,其减少量按份数比例分配至牛油果树果脂、可可籽脂、白蜂蜡、稻胚芽油和角鲨烷中,其余组分及添加量不变。This comparative example provides a moisturizing composition, which differs from Example 1 only in that wheat germ oil is not included, and the reduced amount thereof is distributed among avocado butter, cocoa seed butter, white beeswax, rice germ oil and squalane in proportion to the number of parts, while the other components and the addition amounts remain unchanged.

对比例5Comparative Example 5

本对比例提供一种保湿组合物,所述保湿组合物与实施例1的区别仅在于不包括稻胚芽油,其减少量按份数比例分配至牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油和角鲨烷中,其余组分及添加量不变。This comparative example provides a moisturizing composition, which differs from Example 1 only in that rice germ oil is not included, and the reduced amount thereof is distributed among avocado butter, cocoa seed butter, white beeswax, wheat germ oil and squalane in proportion to the number of parts, while the other components and the addition amounts remain unchanged.

对比例6Comparative Example 6

本对比例提供一种保湿组合物,所述保湿组合物与实施例1的区别仅在于不包括角鲨烷,其减少量按份数比例分配至牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油和稻胚芽油中,其余组分及添加量不变。This comparative example provides a moisturizing composition, which differs from Example 1 only in that squalane is not included, and the reduced amount thereof is distributed to avocado butter, cocoa seed butter, white beeswax, wheat germ oil and rice germ oil in proportion to the number of parts, while the other components and the addition amounts remain unchanged.

应用例1Application Example 1

本应用例制备一种保湿润唇膏,其配方为:实施例1的保湿组合物30份、小烛树蜡8份、辛酸/癸酸甘油三酯62份。This application example prepares a moisturizing lip balm, and its formula is: 30 parts of the moisturizing composition of Example 1, 8 parts of candelilla wax, and 62 parts of caprylic/capric triglyceride.

其制备方法为:Its preparation method is:

(1)将牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷混合后升温至80℃,然后加入辛酸/癸酸甘油三酯和小烛树蜡,混合均匀后保温15min;(1) Avocado butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane are mixed and heated to 80° C., and then caprylic/capric triglyceride and candelilla wax are added, mixed evenly and kept warm for 15 minutes;

(2)保温结束后依次加入全人源TM胶原蛋白,混合均匀后降温至50℃,静 置1h后即得。(2) After the heat preservation, add human TM collagen in sequence, mix well, cool to 50℃, and let stand. Leave it for 1 hour and it is ready.

应用例2-4Application Example 2-4

本应用例提供了三种保湿润唇膏,其配方与应用例1的区别仅在于将实施例1的保湿组合物分别替换为添加量相同的实施例2-4的保湿组合物,其他条件均保持不变,制备方法参照应用例1。This application example provides three moisturizing lip balms, the formulas of which differ from those of application example 1 only in that the moisturizing composition of example 1 is replaced with the moisturizing compositions of examples 2-4 with the same addition amounts, and other conditions remain unchanged. The preparation method refers to application example 1.

应用例5Application Example 5

本应用例制备一种保湿润唇膏,其配方为:实施例1的保湿组合物30份、小烛树蜡8份、植物提取物8份、辛酸/癸酸甘油三酯62份;This application example prepares a moisturizing lip balm, and its formula is: 30 parts of the moisturizing composition of Example 1, 8 parts of candelilla wax, 8 parts of plant extract, and 62 parts of caprylic/capric triglyceride;

所述植物提取物为2:1:1的迷迭香提取物、楔基海带提取物和茶叶提取物的组合。The plant extract is a combination of rosemary extract, laminaria japonica extract and tea extract in a ratio of 2:1:1.

其制备方法为:Its preparation method is:

(1)将牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷混合后升温至80℃,然后加入辛酸/癸酸甘油三酯和小烛树蜡,混合均匀后保温15min;(1) Avocado butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane were mixed and heated to 80° C., and then caprylic/capric triglyceride and candelilla wax were added, mixed evenly and kept warm for 15 minutes;

(2)保温结束后依次加入全人源TM胶原蛋白和植物提取物,混合均匀后降温至50℃,静置1h后即得。(2) After the heat preservation is completed, add the fully human TM collagen and the plant extract in sequence, mix them evenly, cool them to 50°C, and let them stand for 1 hour.

应用例6Application Example 6

本应用例提供了一种保湿润唇膏,其配方与应用例5的区别仅在于植物提取物中不包含迷迭香提取物,其减少量按份数比例分配至楔基海带提取物和茶叶提取物中,其他成分及含量保持不变。制备方法参照应用例1。This application example provides a moisturizing lip balm, the formula of which differs from that of application example 5 only in that the plant extract does not contain rosemary extract, and the reduced amount thereof is distributed to the Laminaria japonica extract and the tea extract in proportion, while the other ingredients and contents remain unchanged. The preparation method is the same as that of application example 1.

应用例7Application Example 7

本应用例提供了一种保湿润唇膏,其配方与应用例5的区别仅在于植物提取物中不包含楔基海带提取物,其减少量按份数比例分配至迷迭香提取物和 茶叶提取物中,其他成分及含量保持不变。制备方法参照应用例1。This application example provides a moisturizing lip balm, the formula of which is different from that of application example 5 only in that the plant extract does not contain Laminaria japonica extract, and the reduced amount thereof is distributed in proportion to the rosemary extract and In the tea extract, other components and contents remain unchanged. The preparation method is referred to Application Example 1.

应用例8Application Example 8

本应用例提供了一种保湿润唇膏,其配方与应用例5的区别仅在于植物提取物中不包含茶叶提取物,其减少量按份数比例分配至迷迭香提取物和楔基海带提取物中,其他成分及含量保持不变。制备方法参照应用例1。This application example provides a moisturizing lip balm, the formula of which is different from that of application example 5 only in that the plant extract does not contain tea extract, and the reduced amount thereof is distributed to rosemary extract and kelp extract in proportion, while the other ingredients and contents remain unchanged. The preparation method is the same as that of application example 1.

对比应用例1-6Comparative Application Examples 1-6

本对比应用例提供了六种保湿润唇膏,其配方与应用例1的区别仅在于将实施例1的保湿组合物分别替换为添加量相同的对比例1-6的保湿组合物,其他条件均保持不变,制备方法参照应用例1。This comparative application example provides six moisturizing lip balms, the formulas of which differ from those of Application Example 1 only in that the moisturizing composition of Example 1 is replaced by the moisturizing compositions of Comparative Examples 1-6 with the same addition amounts, and other conditions remain unchanged. The preparation method refers to Application Example 1.

对比应用例7Comparative Application Example 7

本对比应用例提供了一种保湿润唇膏,其配方与应用例1的区别仅在于不包括实施例1的保湿组合物,其减少量由辛酸/癸酸甘油三酯补足,制备方法参照应用例1。This comparative application example provides a moisturizing lip balm, the formula of which differs from that of Application Example 1 only in that the moisturizing composition of Example 1 is not included, and the reduced amount is supplemented by caprylic/capric triglyceride. The preparation method refers to that of Application Example 1.

试验例1Test Example 1

化妆品急性经口毒性(Acuteoraltoxicity)实验,本试验例中按照化学品急性经口毒性测试GB/T21603的标准进行。The acute oral toxicity test of cosmetics was carried out in accordance with the standard of acute oral toxicity test of chemicals GB/T21603 in this test example.

将应用例1-8提供的保湿润唇膏一次经口给予实验小鼠后,记录小鼠在短期内出现的健康损害效应,所得结果以经口LD50(半数致死量,Mediumlethaldose)表示,其中LD50表示经口一次给予受试物后,引起实验动物总体中半数死亡的毒物的统计学剂量,其判断标准如表1所示:After the moisturizing lip balm provided in Application Example 1-8 was orally administered to experimental mice once, the health damage effects of the mice in the short term were recorded, and the results were expressed as oral LD50 (Medium lethal dose), wherein LD50 represents the statistical dose of the poison that causes half of the death of the experimental animals after the test substance is orally administered once, and the judgment criteria are shown in Table 1:

表1

Table 1

实施例1-8提供的保湿润唇膏的急性经口毒性实验如表2所示:The acute oral toxicity test of the moisturizing lip balm provided in Examples 1-8 is shown in Table 2:

表2
Table 2

由表2可知,本公开提供的保湿润唇膏安全无毒。It can be seen from Table 2 that the moisturizing lip balm provided by the present disclosure is safe and non-toxic.

试验例2Test Example 2

红细胞溶血实验Red blood cell hemolysis test

本项目通过红细胞溶血实验评价刺激性。红细胞溶血实验是兔眼刺激性实验(Draizetest)替代方法之一,基本原理是通过测定血红蛋白溶出量及变性程度来评价化学品对眼组织细胞的损伤。国际上主要将RBC实验用于评价化妆 品及原料等化学品的眼刺激性研究,分级标准如下表3所示。This project evaluates irritation through the red blood cell hemolysis test. The red blood cell hemolysis test is one of the alternative methods for the rabbit eye irritation test (Draizetest). The basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the amount of hemoglobin dissolved and the degree of denaturation. The RBC test is mainly used internationally to evaluate the The eye irritation study of chemicals such as products and raw materials is carried out, and the classification standards are shown in Table 3 below.

表3
Table 3

对应用例1-8的样品进行红细胞溶血实验的结果如表4所示,L/D为HD50(50%红细胞发生溶血时的样品浓度)与DI(蛋白质变性指数)的比值。The results of the red blood cell hemolysis experiment on the samples of Examples 1-8 are shown in Table 4, where L/D is the ratio of HD50 (the sample concentration when 50% of the red blood cells are hemolyzed) to DI (protein denaturation index).

表4

Table 4

由表4可知,本公开所述保湿润唇膏安全可靠,不会对身体造成任何副作用,不会引起任何不良反应的发生,也不会给肌肤带来任何负担。It can be seen from Table 4 that the moisturizing lip balm disclosed in the present invention is safe and reliable, will not cause any side effects to the body, will not cause any adverse reactions, and will not bring any burden to the skin.

试验例3Test Example 3

保湿效果测定Moisturizing effect measurement

选取健康志愿者150名,其中男性75名、女性75名,年龄20~40岁,无严重系统疾病、免疫缺陷或自身免疫性疾病,对化妆品无过敏、面部无急性炎症、未使用激素类药物或免疫抑制剂、未参加其他临床试验,未涂抹外用制剂,随机分为15组,每组10人,分别涂抹上述应用例1-8及对比应用例1-7提供的保湿润唇膏,将唇膏各自涂于所在组的志愿者唇部皮肤,在第0min、30min、60min时利用皮肤水份测试仪(CorneometerCM825)检测唇部皮肤含水量,评估使用所述唇膏前后皮肤的含水量情况,具体测试结果如下表5所示。150 healthy volunteers were selected, including 75 males and 75 females, aged 20 to 40 years old, without severe systemic diseases, immunodeficiency or autoimmune diseases, no allergies to cosmetics, no acute facial inflammation, no use of hormone drugs or immunosuppressants, no participation in other clinical trials, and no application of external preparations. They were randomly divided into 15 groups, 10 people in each group, and the moisturizing lip balms provided by the above-mentioned application examples 1-8 and comparative application examples 1-7 were applied respectively. The lipsticks were applied to the lip skin of the volunteers in their respective groups, and the moisture content of the lip skin was detected by a skin moisture tester (CorneometerCM825) at 0min, 30min, and 60min, and the moisture content of the skin before and after the use of the lipstick was evaluated. The specific test results are shown in Table 5 below.

表5
Table 5

通过表5的数据说明,本应用例1-3制备的润唇膏具有良好的保湿效果, 皮肤含水率0h能够达到68%以上,30min后仍在64%以上,60min后在59%以上。由对比例7可知,添加有本公开的保湿组合物后所述润唇膏能迅速滋润唇部肌肤、锁住肌肤水分,由对比例1-6可知,所述保湿组合物中牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷相互配合,具有协同增效的作用,保湿增效作用显著。The data in Table 5 show that the lip balms prepared in Application Examples 1-3 have good moisturizing effects. The skin moisture content can reach more than 68% at 0h, still more than 64% after 30min, and more than 59% after 60min. Comparative Example 7 shows that after adding the moisturizing composition of the present disclosure, the lip balm can quickly moisturize the lip skin and lock the skin moisture. Comparative Examples 1-6 show that the avocado tree butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane in the moisturizing composition cooperate with each other, have a synergistic effect, and have a significant moisturizing and synergistic effect.

试验例4抗氧化测试Test Example 4 Antioxidant Test

(1)取1g应用例1、5-8的保湿润唇膏,加入2mL无水乙醇,溶解完全后加入2mL的60μmol/L的DPPH溶液混匀,放置30min,以无水乙醇调零,在517nm处测得吸光度为Ai;同样的方法取2mL无水乙醇溶剂+2mLDPPH溶液混匀测定吸光度极为Ac;再取1g组合物基质溶解后加入2mL无水乙醇,再加入2mL无水乙醇溶剂混匀测定吸光度为Aj。(1) Take 1 g of the moisturizing lip balm of Application Examples 1 and 5-8, add 2 mL of anhydrous ethanol, and after complete dissolution, add 2 mL of 60 μmol/L DPPH solution and mix well. Let stand for 30 min, adjust to zero with anhydrous ethanol, and measure the absorbance at 517 nm as Ai; in the same way, take 2 mL of anhydrous ethanol solvent + 2 mL of DPPH solution and mix well to measure the absorbance as Ac; take 1 g of the matrix of the composition and dissolve it, add 2 mL of anhydrous ethanol, and then add 2 mL of anhydrous ethanol solvent and mix well to measure the absorbance as Aj.

按下述公式计算其自由基清除率。The free radical scavenging rate was calculated according to the following formula.

清除率(%)=[1-(Ai-Aj)/Ac]×100%Clearance (%) = [1-(Ai-Aj)/Ac] × 100%

其中,Aj反应样品自身对吸光度的贡献;Ai样品对DPPH作用后的吸光度数值;Ac为DPPH本身在测定波长的吸收。Among them, Aj is the contribution of the reaction sample itself to the absorbance; Ai is the absorbance value of the sample after the action of DPPH; Ac is the absorption of DPPH itself at the measurement wavelength.

DPPH自由基清除率一定程度上反映了其抗氧化能力,其清除率越高,表明其抗氧化程度越好。结果如表6所示(每组样品平行测定5次,数据以平均值呈现)。The DPPH free radical scavenging rate reflects its antioxidant capacity to a certain extent. The higher the scavenging rate, the better the antioxidant degree. The results are shown in Table 6 (each group of samples was measured 5 times in parallel, and the data are presented as average values).

具体测试结果如表6所示:The specific test results are shown in Table 6:

表6

Table 6

由表6可知,由应用例1和应用例5可知,本公开的润唇膏中通过添加具有抗氧化功效的植物提取物,其对DPPH具有较好的清除效果,清除率在85%以上,由应用例6-8可知,表明本公开的植物提取物中迷迭香提取物、楔基海带提取物和茶叶提取物相互配合,在抗氧化效果方法具有协同增效的作用。As shown in Table 6, Application Examples 1 and 5 show that the lip balm of the present invention has a good scavenging effect on DPPH by adding plant extracts with antioxidant effects, and the scavenging rate is above 85%. As shown in Application Examples 6-8, the rosemary extract, Laminaria japonica extract and tea extract in the plant extracts of the present invention cooperate with each other and have a synergistic effect in the antioxidant effect.

试验例5消费者感官效果评价Test Example 5 Consumer Sensory Effect Evaluation

选择150名年龄在30-35岁之间女性志愿者作为受试对象,随机分为15组,每组10人。测试方法:受试对象分别使用应用例1-8和对比应用例1-7的唇膏涂抹唇部,每天2次,连续使用30天,使用结束后由受试对象评价使用唇膏前后的保湿及淡化唇纹效果进行打分,采用5分制:最高分为5分,表示很好,非常满意;4分为较好;3分为中等可以接受;3分以下为不好,不能接受。每组得分均为10人平均值,结果如表7所示。150 female volunteers aged between 30 and 35 were selected as test subjects and randomly divided into 15 groups, with 10 people in each group. Test method: The test subjects applied the lipsticks of application examples 1-8 and comparative application examples 1-7 to their lips, twice a day, for 30 consecutive days. After the use, the test subjects evaluated the moisturizing and lip wrinkle lightening effects before and after the use of the lipsticks and scored them using a 5-point system: the highest score was 5 points, indicating very good, very satisfactory; 4 points were good; 3 points were moderately acceptable; and less than 3 points were not good, unacceptable. The scores of each group were the average of 10 people, and the results are shown in Table 7.

表7

Table 7

根据表7可知,本公开的润唇膏通过各功效成分的科学配比,达到了良好的保湿效果,添加植物提取物后,淡化唇纹的效果更佳。According to Table 7, the lip balm disclosed in the present invention achieves a good moisturizing effect through the scientific ratio of various functional ingredients. After adding plant extracts, the effect of reducing lip lines is better.

申请人声明,本公开通过上述实施例来说明本公开的一种保湿组合物及其应用,但本公开并不局限于上述实施例,即不意味着本公开必须依赖上述实施例才能实施。所属技术领域的技术人员应该明了,对本公开的任何改进,对本公开产品各原料的等效替换及辅助成分的添加、具体方式的选择等,均落在本公开的保护范围和公开范围之内。The applicant declares that the present disclosure uses the above-mentioned embodiments to illustrate a moisturizing composition and its application, but the present disclosure is not limited to the above-mentioned embodiments, that is, it does not mean that the present disclosure must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement to the present disclosure, equivalent replacement of the raw materials of the present product, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present disclosure.

以上详细描述了本公开的优选实施方式,但是,本公开并不限于上述实施方式中的具体细节,在本公开的技术构思范围内,可以对本公开的技术方案进行多种简单变型,这些简单变型均属于本公开的保护范围。The preferred embodiments of the present disclosure are described in detail above; however, the present disclosure is not limited to the specific details in the above embodiments. Within the technical concept of the present disclosure, a variety of simple modifications can be made to the technical solution of the present disclosure, and these simple modifications all fall within the protection scope of the present disclosure.

另外需要说明的是,在上述具体实施方式中所描述的各个具体技术特征,在不矛盾的情况下,可以通过任何合适的方式进行组合,为了避免不必要的重复,本公开对各种可能的组合方式不再另行说明。 It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present disclosure will not further describe various possible combinations.

工业实用性Industrial Applicability

(1)本公开的保湿组合物中牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷各组分配伍合理,具有协同增效作用,可使组合物具有更加优异的保湿效果。且各组分均为天然植物成分,温和安全,对皮肤无刺激,符合化妆品市场绿色环保潮流,不仅使消费者更安心的使用,还可以提高消费者的购买欲望。(1) The components of avocado tree butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane in the moisturizing composition disclosed herein are reasonably formulated and have a synergistic effect, which can make the composition have a more excellent moisturizing effect. Moreover, each component is a natural plant ingredient, which is mild and safe, has no irritation to the skin, and conforms to the green and environmental protection trend of the cosmetics market, which not only makes consumers feel more at ease when using it, but also can increase consumers' desire to buy it.

(2)本公开的唇膏的组分选择保湿组合物、辛酸/癸酸甘油三酯和小烛树蜡,各组分相互配合,涂上嘴唇后,可更快速地起到保湿效果,使得嘴唇更加光滑并具有滋润保湿等诸多功能。 (2) The components of the lipstick disclosed in the present invention are selected from a moisturizing composition, caprylic/capric triglyceride and candelilla wax. The components cooperate with each other and can more quickly achieve a moisturizing effect after being applied to the lips, making the lips smoother and having many other functions such as moisturizing and hydrating.

Claims (10)

一种保湿组合物,其特征在于,所述保湿组合物包括牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷。A moisturizing composition, characterized in that the moisturizing composition comprises avocado butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane. 如权利要求1所述的保湿组合物,其特征在于,所述保湿组合物按重量份数计包括牛油果树果脂5-15份、可可籽脂1-5份、白蜂蜡1-5份、小麦胚芽油5-15份、稻胚芽油5-15份和角鲨烷20-30份;The moisturizing composition according to claim 1, characterized in that the moisturizing composition comprises, by weight, 5-15 parts of avocado butter, 1-5 parts of cocoa seed butter, 1-5 parts of white beeswax, 5-15 parts of wheat germ oil, 5-15 parts of rice germ oil and 20-30 parts of squalane; 优选地,所述保湿组合物按重量份数计包括牛油果树果脂8-12份、可可籽脂2-4份、白蜂蜡2-4份、小麦胚芽油8-12份、稻胚芽油6-13份和角鲨烷22-28份。Preferably, the moisturizing composition comprises, by weight, 8-12 parts of avocado butter, 2-4 parts of cocoa seed butter, 2-4 parts of white beeswax, 8-12 parts of wheat germ oil, 6-13 parts of rice germ oil and 22-28 parts of squalane. 如权利要求1或2所述的保湿组合物,其特征在于,所述保湿组合物还包括全人源TM胶原蛋白,所述全人源TM胶原蛋白包括:水、甘油、磷酸二氢钠、磷酸氢二钠、可溶性胶原;The moisturizing composition according to claim 1 or 2, characterized in that the moisturizing composition further comprises fully human TM collagen, and the fully human TM collagen comprises: water, glycerol, sodium dihydrogen phosphate, sodium dihydrogen phosphate, and soluble collagen; 优选地,所述全人源TM胶原蛋白的添加量为0.05-0.15份。Preferably, the added amount of the fully human TM collagen is 0.05-0.15 parts. 如权利要求1-3中任一项所述的保湿组合物在化妆品中的应用。Use of the moisturizing composition according to any one of claims 1 to 3 in cosmetics. 如权利要求4所述的应用,其特征在于,所述化妆品包括唇膏、精华霜、面霜或面膜;The use according to claim 4, characterized in that the cosmetics include lipstick, essence cream, face cream or facial mask; 优选地,所述保湿组合物在所述化妆品中的质量百分含量为1-30%。Preferably, the mass percentage of the moisturizing composition in the cosmetic is 1-30%. 一种保湿润唇膏,其特征在于,所述保湿润唇膏包括如权利要求1-3中任一项所述的保湿组合物、辛酸/癸酸甘油三酯和小烛树蜡。A moisturizing lip balm, characterized in that the moisturizing lip balm comprises the moisturizing composition according to any one of claims 1 to 3, caprylic/capric triglyceride and candelilla wax. 如权利要求6所述的保湿润唇膏,其特征在于,所述保湿润唇膏按重量份数计包括如权利要求1-3中任一项所述的保湿组合物5-40份、辛酸/癸酸甘油三酯50-70份和小烛树蜡1-15份;The moisturizing lip balm according to claim 6, characterized in that the moisturizing lip balm comprises, by weight, 5-40 parts of the moisturizing composition according to any one of claims 1 to 3, 50-70 parts of caprylic/capric triglyceride, and 1-15 parts of candelilla wax; 优选地,所述保湿润唇膏还包括有植物提取物; Preferably, the moisturizing lip balm further comprises plant extracts; 优选地,所述植物提取物在所述保湿润唇膏中的质量百分含量为1-10%;Preferably, the mass percentage of the plant extract in the moisturizing lip balm is 1-10%; 优选地,所述植物提取物包括迷迭香提取物、楔基海带提取物或茶叶提取物中的任意一种或至少两种的组合;Preferably, the plant extract comprises any one of rosemary extract, Laminaria japonica extract or tea extract, or a combination of at least two thereof; 优选地,所述植物提取物包括迷迭香提取物、楔基海带提取物和茶叶提取物的组合;Preferably, the plant extract comprises a combination of rosemary extract, Laminaria japonica extract and tea extract; 优选地,所述迷迭香提取物、楔基海带提取物和茶叶提取物的质量比为(1-3):(1-2):(0.1-1)。Preferably, the mass ratio of the rosemary extract, the Laminaria japonica extract and the tea extract is (1-3):(1-2):(0.1-1). 如权利要求6或7所述的保湿润唇膏的制备方法,其特征在于,所述保湿润唇膏的制备方法包括将保湿组合物、油脂和小烛树蜡搅拌混合后即得。The method for preparing a moisturizing lip balm according to claim 6 or 7, characterized in that the method for preparing the moisturizing lip balm comprises stirring and mixing the moisturizing composition, oil and candelilla wax. 如权利要求8所述的保湿润唇膏的制备方法,其特征在于,所述制备方法包括:The method for preparing the moisturizing lip balm according to claim 8, characterized in that the preparation method comprises: (1)将牛油果树果脂、可可籽脂、白蜂蜡、小麦胚芽油、稻胚芽油和角鲨烷混合后升温,然后加入辛酸/癸酸甘油三酯和小烛树蜡,混合均匀后保温;(1) mixing avocado butter, cocoa seed butter, white beeswax, wheat germ oil, rice germ oil and squalane, heating the mixture, then adding caprylic/capric triglyceride and candelilla wax, mixing the mixture evenly and keeping the mixture warm; (2)保温结束后依次加入全人源TM胶原蛋白和植物提取物,混合均匀后降温,静置后即得。(2) After the heat preservation is completed, add the fully human TM collagen and the plant extract in sequence, mix them evenly, cool them down, and let them stand to obtain the product. 如权利要求9所述的保湿润唇膏的制备方法,其特征在于,步骤(1)所述升温至70-90℃;The method for preparing a moisturizing lip balm according to claim 9, characterized in that the temperature is raised to 70-90° C. in step (1); 优选地,步骤(1)所述保温时间为8-20min;Preferably, the insulation time in step (1) is 8-20 min; 优选地,步骤(2)所述降温至50-60℃;Preferably, the temperature in step (2) is lowered to 50-60°C; 优选地,步骤(2)所述静置时间为0.5-1h。 Preferably, the standing time in step (2) is 0.5-1h.
PCT/CN2024/124544 2023-10-12 2024-10-12 Moisturizing composition and use thereof Pending WO2025077900A1 (en)

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