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WO2025075452A1 - Dispositif de soins de la peau - Google Patents

Dispositif de soins de la peau Download PDF

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Publication number
WO2025075452A1
WO2025075452A1 PCT/KR2024/015136 KR2024015136W WO2025075452A1 WO 2025075452 A1 WO2025075452 A1 WO 2025075452A1 KR 2024015136 W KR2024015136 W KR 2024015136W WO 2025075452 A1 WO2025075452 A1 WO 2025075452A1
Authority
WO
WIPO (PCT)
Prior art keywords
fat
proliferation
human body
ultrasonic
ultrasound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/KR2024/015136
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English (en)
Korean (ko)
Inventor
김형문
강동환
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jeisys Medical Inc
Original Assignee
Jeisys Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020240120985A external-priority patent/KR20250049944A/ko
Application filed by Jeisys Medical Inc filed Critical Jeisys Medical Inc
Publication of WO2025075452A1 publication Critical patent/WO2025075452A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia

Definitions

  • HIFU high intensity focused ultrasound
  • the purpose of the embodiments disclosed in the present disclosure is to provide something that can improve fat proliferation in a human body by irradiating the human body with ultrasonic energy corresponding to fat proliferation.
  • the ultrasonic energy corresponding to the above fat proliferation can be characterized as being 0.01 to 0.2 J.
  • the processor may be connected to the acquisition device by wire or wirelessly, and the ultrasonic irradiation unit may further irradiate ultrasonic energy corresponding to the fat proliferation to a target depth of the human body linked to the thickness information for each irradiation location of the human body acquired through the acquisition device before or after the irradiation of the ultrasonic energy.
  • the ultrasound irradiation unit may be characterized by further irradiating ultrasound energy corresponding to the fat proliferation at a right angle or an oblique angle with respect to the surface of the human body.
  • the human body may be characterized by at least one of a face, buttocks, chest, and a sunken area.
  • the ultrasound irradiation unit may be characterized by further irradiating ultrasound energy corresponding to the fat proliferation to at least one of the deep fat layer of the face, the area under the buttocks, the area under the chest, and the area under the sunken area.
  • the processor may be characterized in that, when the processor is connected to the acquisition device by wire or wireless connection and receives skin skeletal information acquired through the acquisition device, the processor further determines a location where there is a gap within the individual area requiring fat proliferation based on the skin skeletal information; and the ultrasound irradiation unit may further irradiate ultrasound energy corresponding to the fat proliferation to the location where there is a gap.
  • the device may further include a high-frequency irradiation unit that irradiates high-frequency based on a dielectric electrode to a deep fat layer of the face; and the ultrasonic irradiation unit may be characterized in that the high-frequency irradiation unit irradiates high-frequency energy to a retaining ligament and further irradiates ultrasonic energy corresponding to the fat proliferation to a location where there is a sag within an individual area where the fat proliferation is required.
  • the ultrasound irradiation unit may be characterized in that, when the human body is a face, it further irradiates ultrasound energy corresponding to the fat proliferation at a right angle or an oblique angle with respect to the broad surface of the face.
  • Figure 1 is a drawing showing the configuration of a skin care system according to the present disclosure.
  • Fig. 2 is a drawing showing the configuration of the skin care device of Fig. 1.
  • Fig. 4 is a drawing showing the process of fat proliferation in the buttocks using the skin care device of Fig. 1.
  • Fig. 5 is a drawing showing the process of fat proliferation in the chest using the skin care device of Fig. 1.
  • Figure 6 is a drawing showing another example of the process in which the ultrasonic irradiation unit of Figure 2 irradiates ultrasonic waves.
  • Figure 7 is a diagram showing the fat pad and individual areas requiring fat proliferation.
  • Figure 8 is a diagram showing the sequence of occurrence of fat loss during the human skin aging process.
  • Figures 9 and 10 are drawings showing the superficial facial fat pad and the deep facial fat pad.
  • Figures 11 and 12 are drawings showing changes in HSP70 expression through ciliary regulation of adipose-derived stem cells after ultrasonic irradiation of the ultrasonic irradiation unit of Figure 2.
  • Figures 14 and 15 are drawings showing the change in adipogenesis through regulation of ciliary length of adipose-derived stem cells after ultrasound irradiation of the ultrasound irradiation unit of Figure 2.
  • first, second, etc. are used to distinguish one component from another, and the components are not limited by the aforementioned terms.
  • Figure 6 is a drawing showing another example of the process in which the ultrasonic probe of Figure 2 irradiates ultrasonic waves.
  • Figure 7 is a drawing showing a fat pad and an individual area requiring fat proliferation.
  • the ultrasonic energy may be 0.01 to 0.2 J, preferably 0.1 to 0.2 J, and most preferably 0.1 J.
  • the ultrasonic energy is less than 0.01 J, the effect of fat proliferation is minimal, and when the ultrasonic energy exceeds 0.2 J, the effect of fat reduction can be exerted.
  • the ultrasound irradiation unit (110) irradiates ultrasound energy corresponding to fat proliferation to activate fat proliferation in fat pads (PD1 to PD5) provided at an irradiation location of the buttocks (S1), and irradiates ultrasound energy corresponding to fat proliferation to individual areas directly requiring fat proliferation among the irradiation locations of the buttocks (S1).
  • the fat pads (PD1 to PD5) may have the same size or may have different sizes.
  • the individual area requiring fat proliferation may be an area of the fat pads (PD1 to PD5) or an area excluding the fat pads (PD1 to PD5).
  • the individual area may be a sunken area area of the buttocks (S1) or an area below the buttocks (S1).
  • the ultrasound irradiation unit (110) irradiates ultrasound energy corresponding to fat proliferation to activate fat proliferation in the fat pads (PD6 to PD9) provided at the irradiation location of the chest (S2), and can irradiate ultrasound energy corresponding to fat proliferation to individual areas directly requiring fat proliferation among the irradiation locations of the chest (S2).
  • the fat pads (PD6 to PD9) may have the same size or may have different sizes.
  • the individual area requiring fat proliferation may be an area of the fat pads (PD6 to PD9) or an area excluding the fat pads (PD6 to PD9).
  • the individual area may be an area of a sunken area of the chest (S2) or an area below the chest (S2).
  • the processor (122) may be connected to the acquisition device (10) by wire or wirelessly.
  • the ultrasonic irradiation unit (110) may irradiate ultrasonic energy corresponding to fat proliferation to the target depth of the buttocks (S1) linked to the thickness information for each irradiation location based on the thickness information for each irradiation location of the buttocks (S1) acquired through the acquisition device (10) before or after the irradiation of ultrasonic energy.
  • the processor (122) may be connected to the acquisition device (10) by wire or wirelessly.
  • the ultrasound irradiation unit (110) may irradiate ultrasound energy corresponding to fat proliferation to the target depth of the chest (S2) linked to the thickness information for each irradiation location based on the thickness information for each irradiation location of the chest (S2) acquired through the acquisition device (10) before or after the irradiation of the ultrasound energy.
  • the present disclosure can activate fat proliferation in fat pads (PD1 to PD5, PD6 to PD9, BPD) provided at at least one of the buttocks (S1), the chest (S2), and the deep fat layer (S11) for each person linked to the thickness information of each investigation location acquired for each person, by irradiating ultrasound energy corresponding to fat proliferation, and can irradiate ultrasound energy corresponding to fat proliferation to individual areas where fat proliferation is directly required among the investigation locations of the buttocks (S1), the chest (S2), and the deep fat layer (S11) for each person.
  • fat pads PD1 to PD5, PD6 to PD9, BPD
  • the processor (122) may be connected to the ultrasonic imaging device (20) by wire or wirelessly.
  • the ultrasonic irradiation unit (110) irradiates ultrasonic energy corresponding to fat proliferation to at least one of the buttocks (S1), the chest (S2), and the deep fat layer (S11)
  • the ultrasonic imaging device (20) may be further controlled so that at least one of the focusing position and target depth of at least one of the buttocks (S1), the chest (S2), and the deep fat layer (S11) is captured and displayed.
  • the present disclosure captures and displays at least one peripheral location among a hip, a chest, and a cheekbone, and since there may be a difference in at least one of the focus locations and target depths of the hip (S1), the chest (S2), and the deep fat layer (S11) for each person, at least one of the focus locations and target depths of the hip (S1), the chest (S2), and the deep fat layer (S111) for each person can be accurately captured and displayed.
  • the user can confirm at least one of the focus locations and target depths of the hip (S1), the chest (S2), and the deep fat layer (S11) for each person.
  • the processor (122) can further determine the location where there is an off-axis within the individual area based on the external shape information of the buttocks (S1) or the chest (S2).
  • the ultrasound irradiation unit (110) can further irradiate ultrasound energy corresponding to fat proliferation to the location where there is an off-axis.
  • the processor (121) is connected to the acquisition device (10) by wire or wireless connection, and when skin skeleton information acquired through the acquisition device (10) is received, the processor (121) can further determine the location where there is an off-line in the individual area based on the skin skeleton information. At this time, the ultrasound irradiation unit (110) can further irradiate ultrasound energy corresponding to fat proliferation to the location where there is an off-line.
  • the order of occurrence of fat loss during the human skin aging process can proceed in the order of P1, P2, P3, P4, and P5.
  • the skin care device (100) may further include a high-frequency irradiation unit (130).
  • the high-frequency irradiation unit (130) may irradiate high-frequency based on a dielectric electrode to at least one of the buttocks (S1), the chest (S2), and the deep fat layer (S11).
  • the dielectric electrode may be a monopolar type electrode or a bipolar type electrode.
  • the ultrasound irradiation unit (110) can irradiate high-frequency energy to at least one of the buttocks (S1), chest (S2), and retaining ligament by the high-frequency irradiation unit (130), and can further irradiate ultrasonic energy corresponding to fat proliferation to the location where there is a bulge.
  • the present disclosure enables volumetric heating according to the operating mechanism, when irradiating high frequency through the high frequency irradiation unit (130), the fat reduction in the location where there is a sag can be improved by irradiating ultrasonic energy corresponding to the fat proliferation.
  • the ultrasound irradiation unit (110) can further irradiate ultrasound energy corresponding to fat proliferation at a right angle or an oblique angle to the surface of the buttocks (S1) or chest (S2).
  • the present disclosure can efficiently irradiate ultrasound energy corresponding to fat proliferation on the buttocks (S1) or the chest (S2) for each patient. That is, the ultrasound irradiation unit (110) can increase the efficiency of the irradiation by irradiating ultrasound energy with a motion such as pushing the buttocks (S1) or the chest (S2). Therefore, it is preferable that the ultrasound irradiation unit (110) be designed with a structure that can irradiate ultrasound energy with a motion such as pushing the buttocks (S1) or the chest (S2).
  • the ultrasound irradiation unit (110) can further irradiate ultrasound energy corresponding to fat proliferation to at least one of the area under the buttocks (PD5), the area under the chest (PD9), the deep fat layer (S11) of the area under the eyes, and the area under the sunken area.
  • the ultrasound irradiation unit (110) can be provided in a pen type to irradiate ultrasound energy corresponding to fat proliferation to at least one of the area under the buttocks (PD5), the area under the chest (PD9), the deep fat layer (S11) of the area under the eyes, and the area under the sunken area.
  • the processor (122) may be connected to the ultrasonic imaging device (20) by wire or wirelessly.
  • the ultrasonic irradiation unit (110) may further irradiate ultrasonic energy corresponding to fat proliferation to at least one of the buttocks (S1), the chest (S2), and the deep fat layer (S11) based on the image of the polymer particle injected into at least one of the buttocks (S1), the chest (S2), and the deep fat layer (S11) obtained through the ultrasonic imaging device (20).
  • the polymer particle may be a 30 to 40 nm particle, and may be an exosome.
  • the present disclosure can improve fat proliferation by scattering ultrasonic energy corresponding to fat proliferation at a location where polymer particles are injected, thereby irradiating ultrasonic energy corresponding to fat proliferation to a deeper location.
  • Figures 11 and 12 are drawings for showing changes in HSP70 expression through ciliary regulation of adipose-derived stem cells after ultrasonic irradiation of the ultrasonic irradiation unit of Figure 2.
  • Figure 13 is a drawing for showing changes in ciliary length of adipose-derived stem cells after ultrasonic irradiation of the ultrasonic irradiation unit of Figure 2.
  • the change in HSP70 expression through ciliary regulation of adipose-derived stem cells was analyzed after ultrasound irradiation on minipigs.
  • the HSP70 expression change image (C1) and HSP70 expression change graph (C2) were the highest after 1 day of ultrasound irradiation, and gradually decreased over time, such as after 3 days, 7 days, and 28 days, compared to the control group that was not subjected to ultrasound irradiation.
  • Figures 14 and 15 are drawings for showing the change in adipogenesis through the regulation of ciliary length of adipose-derived stem cells after ultrasonic irradiation of the ultrasonic irradiation unit of Figure 2.
  • Figures 16 to 18 are drawings for showing the change in the number of fat cells and the thickness of the fat layer through the regulation of ciliary length of adipose-derived stem cells after ultrasonic irradiation of the ultrasonic irradiation unit of Figure 2.
  • the Adipogenesis changes through ciliary length regulation of adipose-derived stem cells were analyzed.
  • the Adipogenesis graph (C4) was the highest after 28 days of ultrasound irradiation in the case of PPAR ⁇ , compared to the control group that was not irradiated with ultrasound.
  • the Adipogenesis graph (C5) was the highest after 7 days of ultrasound irradiation in the case of CEBP ⁇ , compared to the control group that was not irradiated with ultrasound.
  • the number of adipocytes and the change in the thickness of the fat layer through the regulation of the cilia length of adipose-derived stem cells after ultrasound irradiation on minipigs were analyzed.
  • the graph (C7) for the number of adipocytes in the fat image (C6) was the largest after 7 days of ultrasound irradiation compared to the control group that was not subjected to ultrasound irradiation.
  • the graph (C8) for the thickness of the fat layer in the fat image (C6) was the largest after 28 days of ultrasound irradiation compared to the control group that was not subjected to ultrasound irradiation.
  • Figure 19 is a drawing to show the change in HSP70 before and after ultrasonic irradiation of the ultrasonic irradiation unit of Figure 2.
  • the HSP70 change graph (C9) showed an improvement effect of 116% when ultrasound was irradiated once at the target ultrasound energy to the zygomatic arch fat of the minipig, and an improvement effect of 531% when ultrasound was irradiated four times at the target ultrasound energy to the zygomatic arch fat of the minipig.
  • the HSP70 change graph (C9) showed an improvement effect of 213% when ultrasound was irradiated once at the target ultrasound energy to the lateral temporal fat of the minipig, and an improvement effect of 336% when ultrasound was irradiated four times at the target ultrasound energy to the lateral temporal fat of the minipig.
  • the HSP70 change graph (C9) showed a 53% improvement effect when ultrasound was irradiated once at the target ultrasound energy to the mandible fat of the minipig, and a 79% improvement effect when ultrasound was irradiated four times at the target ultrasound energy to the mandible fat of the minipig.
  • the CD166 change graph (C10) showed an improvement effect of 1599% when ultrasound was irradiated once at the target ultrasound energy to the zygomatic arch fat of the minipig, and an improvement effect of 2997% when ultrasound was irradiated four times at the target ultrasound energy to the zygomatic arch fat of the minipig.
  • CD166 change graph (C10) showed an improvement effect of 896% when ultrasound was irradiated once at the target ultrasound energy to the lateral temporal fat of the minipig, and an improvement effect of 1155% when ultrasound was irradiated four times at the target ultrasound energy to the lateral temporal fat of the minipig.
  • CD166 change graph (C10) showed an improvement effect of 256% when ultrasound was irradiated once at the target ultrasound energy to the mandible fat of the minipig, and an improvement effect of 301% when ultrasound was irradiated four times at the target ultrasound energy to the mandible fat of the minipig.
  • the ARL13B change graph (C11) showed an improvement effect of 76% when ultrasound was irradiated once at the target ultrasound energy to the mandible fat of the minipig, and an improvement effect of 103% when ultrasound was irradiated four times at the target ultrasound energy to the mandible fat of the minipig.
  • the AURKA change graph (C12) showed an improvement effect of 961% when ultrasound was irradiated once at the target ultrasound energy to the zygomatic arch fat of the minipig, and an improvement effect of 1962% when ultrasound was irradiated four times at the target ultrasound energy to the zygomatic arch fat of the minipig.
  • the AURKA change graph (C12) showed an improvement effect of 180% when ultrasound was irradiated once at the target ultrasound energy to the lateral temporal fat of minipigs, and an improvement effect of 460% when ultrasound was irradiated four times at the target ultrasound energy to the lateral temporal fat of minipigs.
  • the AURKA change graph (C12) showed an improvement effect of 144% when ultrasound was irradiated once at the target ultrasound energy to the mandible fat of minipigs, and an improvement effect of 283% when ultrasound was irradiated four times at the target ultrasound energy to the mandible fat of minipigs.
  • the AURKA change graph (C12) showed no improvement when ultrasound was irradiated once at the target ultrasound energy to the frontal fat of the minipig, or when ultrasound was irradiated four times at the target ultrasound energy to the frontal fat of the minipig.
  • Figure 23 is a diagram showing the change in CEBP ⁇ before and after ultrasonic irradiation of the ultrasonic irradiation portion of Figure 2.
  • Figure 24 is a diagram showing the change in PPAR ⁇ before and after ultrasonic irradiation of the ultrasonic irradiation portion of Figure 2.
  • the CEBP ⁇ change graph (C13) showed an improvement effect of 542% when ultrasound was irradiated once at the target ultrasound energy to the zygomatic arch fat of the minipig, and an improvement effect of 1160% when ultrasound was irradiated four times at the target ultrasound energy to the zygomatic arch fat of the minipig.
  • CEBP ⁇ change graph (C13) showed a 97% improvement effect when ultrasound was irradiated once at the target ultrasound energy to the mandible fat of the minipig, and a 157% improvement effect when ultrasound was irradiated four times at the target ultrasound energy to the mandible fat of the minipig.
  • the CEBP ⁇ change graph (C13) showed no improvement when ultrasound was irradiated once at the target ultrasound energy to the frontal fat of minipigs, or when ultrasound was irradiated four times at the target ultrasound energy to the frontal fat of minipigs.
  • the PPAR ⁇ change graph (C14) showed an improvement effect of 194% when ultrasound was irradiated once at the target ultrasound energy to the lateral temporal fat of minipigs, and an improvement effect of 635% when ultrasound was irradiated four times at the target ultrasound energy to the lateral temporal fat of minipigs.
  • the PPAR ⁇ change graph (C14) showed a 96% improvement effect when ultrasound was irradiated once at the target ultrasound energy to the mandible fat of minipigs, and a 113% improvement effect when ultrasound was irradiated four times at the target ultrasound energy to the mandible fat of minipigs.
  • the PPAR ⁇ change graph (C14) showed no improvement when ultrasound was irradiated once at the target ultrasound energy to the frontal fat of minipigs, or when ultrasound was irradiated four times at the target ultrasound energy to the frontal fat of minipigs.
  • At least one component may be added or deleted in accordance with the performance of the components illustrated in FIGS. 1 to 24.
  • the mutual positions of the components may be changed in accordance with the performance or structure of the system.

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Abstract

La présente divulgation comprend : une unité d'exposition à un rayonnement ultrasonore pour exposer le corps humain à un rayonnement d'une énergie ultrasonore ; et un processeur pour commander le fonctionnement de l'unité d'exposition à un rayonnement ultrasonore, l'unité d'exposition à un rayonnement ultrasonore pouvant exposer le corps humain à un rayonnement d'une énergie ultrasonore correspondant à la prolifération de graisse à un emplacement d'exposition à un rayonnement.
PCT/KR2024/015136 2023-10-05 2024-10-04 Dispositif de soins de la peau Pending WO2025075452A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR20230132556 2023-10-05
KR10-2023-0132556 2023-10-05
KR10-2024-0007845 2024-01-18
KR20240007845 2024-01-18
KR1020240120985A KR20250049944A (ko) 2023-10-05 2024-09-05 피부 관리 장치
KR10-2024-0120985 2024-09-05

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WO2025075452A1 true WO2025075452A1 (fr) 2025-04-10

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Citations (4)

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Publication number Priority date Publication date Assignee Title
KR20070094620A (ko) * 2005-01-10 2007-09-20 총칭 하이푸 테크놀로지 코 엘티디 고강도 집적 초음파 처치용 입자 강화제 및 그의 용도
KR20200037881A (ko) * 2008-06-06 2020-04-09 얼테라, 인크 초음파 치료 시스템
KR20230000081U (ko) * 2020-05-04 2023-01-10 비티엘 헬쓰케어 테크놀로지스 에이.에스. 환자의 무인 치료를 위한 디바이스 및 방법
KR20230171905A (ko) * 2022-06-14 2023-12-21 주식회사 제이시스메디칼 초음파 발생 장치

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KR20070094620A (ko) * 2005-01-10 2007-09-20 총칭 하이푸 테크놀로지 코 엘티디 고강도 집적 초음파 처치용 입자 강화제 및 그의 용도
KR20200037881A (ko) * 2008-06-06 2020-04-09 얼테라, 인크 초음파 치료 시스템
KR20230000081U (ko) * 2020-05-04 2023-01-10 비티엘 헬쓰케어 테크놀로지스 에이.에스. 환자의 무인 치료를 위한 디바이스 및 방법
KR20230171905A (ko) * 2022-06-14 2023-12-21 주식회사 제이시스메디칼 초음파 발생 장치

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Title
BYUN KYUNG A., KIM HYOUNG MOON, OH SEYEON, BATSUKH SOSORBURAM, LEE SANGSU, OH MYUNGJUNE, LEE JEONGWOO, LEE RAN, KIM JAE WOO, OH SE: "High-Intensity Focused Ultrasound Increases Facial Adipogenesis in a Swine Model via Modulation of Adipose-Derived Stem Cell Cilia", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, no. 14, 12 July 2024 (2024-07-12), CH, pages 7648 - 7648-13, XP093299898, ISSN: 1422-0067, DOI: 10.3390/ijms25147648 *
OH SEYEON, KIM HYOUNG MOON, BATSUKH SOSORBURAM, SUN HYE JIN, KIM TAEHUI, KANG DONGHWAN, SON KUK HUI, BYUN KYUNGHEE: "High-Intensity Focused Ultrasound Induces Adipogenesis via Control of Cilia in Adipose-Derived Stem Cells in Subcutaneous Adipose Tissue", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, no. 16, 9 August 2022 (2022-08-09), CH, pages 8866 - 8866-14, XP093299897, ISSN: 1422-0067, DOI: 10.3390/ijms23168866 *

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