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WO2025074704A1 - Dispositif d'aide à la diminution progressive de médicament, procédé d'aide à la diminution progressive de médicament, programme et système d'aide à la diminution progressive de médicament - Google Patents

Dispositif d'aide à la diminution progressive de médicament, procédé d'aide à la diminution progressive de médicament, programme et système d'aide à la diminution progressive de médicament Download PDF

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Publication number
WO2025074704A1
WO2025074704A1 PCT/JP2024/025117 JP2024025117W WO2025074704A1 WO 2025074704 A1 WO2025074704 A1 WO 2025074704A1 JP 2024025117 W JP2024025117 W JP 2024025117W WO 2025074704 A1 WO2025074704 A1 WO 2025074704A1
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Prior art keywords
drug
medication
user
support device
dosage
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PCT/JP2024/025117
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English (en)
Japanese (ja)
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誠 大野
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Individual
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Individual
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

Definitions

  • the present invention relates to a medication reduction support device, a medication reduction support method, a program, and a medication reduction support system.
  • the present invention claims priority to Japanese patent application number 2023-172759 filed on October 4, 2023, and the contents of that application are incorporated by reference into this application in designated countries where incorporation by reference to literature is permitted.
  • Patients with insomnia may be prescribed psychotropic drugs (hereafter simply referred to as "medicines") such as benzodiazepines for the purpose of treating the condition. If the patient continues to take the drug for a long period of time, they may develop physical dependence, and once physical dependence has developed, it becomes difficult for the patient to stop taking the drug even if the cause of the insomnia (stress, etc.) is removed. Furthermore, if the patient tries to stop taking the drug forcibly, withdrawal symptoms such as insomnia, anxiety, restlessness, headache, vomiting, and psychomotor agitation may occur, so it is important to gradually reduce the dosage. In particular, if the patient has been taking the drug for a long period of time, a more gradual reduction in the dosage is necessary.
  • psychotropic drugs hereafter simply referred to as "medicines”
  • benzodiazepines for the purpose of treating the condition.
  • Aqueous titration is known as a method of reducing medication.
  • aqueous titration a specified amount of medication is dissolved in a specified amount of water to create an aqueous solution, which is then precisely measured and administered. Reducing medication using aqueous titration reduces the likelihood of withdrawal symptoms occurring.
  • aqueous titration requires difficult medication management in units of a few milligrams, which can be time-consuming for patients, and this can be stressful for patients and have a negative impact on insomnia.
  • Cited Document 1 describes a technology that calculates a patient's biometric information (sleep time, etc.) from a sensor signal of a wristband worn by the patient after taking medication, and calculates the correlation between the drug's effects, side effects, and dosage by referring to the medication information that includes the biometric information.
  • Patent Document 1 makes it possible to calculate the correlation between a drug's effectiveness, side effects, and dosage by referring to factors such as the amount of sleep after taking the drug, but it is not possible to determine an appropriate dosage based on the patient's physical condition before taking the drug.
  • the present invention was made in consideration of these circumstances, and aims to make it possible to determine the appropriate dosage of medication that should be reduced based on the patient's physical condition.
  • the present application includes multiple means for solving at least some of the above problems, examples of which are as follows:
  • a medication reduction support device that supports a user taking medication to reduce the amount of medication, and includes an input unit that accepts input of the user's physical condition, a determination unit that determines the dosage based on the user's physical condition, determines the amount of the medication to be administered based on the determined dosage, and determines the amount of aqueous solution in which the determined amount of medication has been dissolved to be extracted, and an output unit that outputs at least one of the determined dosage, the amount of the medication to be administered, and the amount of the aqueous solution to be extracted.
  • the input unit can accept a selection input from the user of multiple options related to physical condition, and the decision unit can decrease the dosage when the user selects and inputs a first physical condition as the option, and can increase the dosage when the user selects and inputs a second physical condition as the option.
  • the decision unit can decrease the dosage when the number of consecutive times the user selects and inputs the first physical condition is equal to or greater than a first threshold, and can increase the dosage when the number of consecutive times the user selects and inputs the second physical condition is equal to or greater than a second threshold.
  • the determination unit can determine the number of tablets of the drug as the input amount by dividing the determined dosage by the ingredient content per tablet of the drug and rounding up the quotient to a positive number.
  • the drug reduction support device may include a mixing container for dissolving the input amount of the drug in a predetermined amount of water, and a mixing mechanism for mixing the drug and the water in the mixing container to create the aqueous solution.
  • the drug reduction support device may be equipped with an extraction pump that extracts the aqueous solution in the mixing vessel.
  • control unit 20 When the user selects and inputs a physical condition using the physical condition selection button 1103 on the home screen 1100 displayed on the touch panel display 11, the control unit 20 then performs a medication dosage determination process based on the user's physical condition, etc. (step S3).
  • FIG. 6 is a flowchart explaining an example of the medication dosage determination process.
  • the control unit 20 determines whether the physical condition selected and input by the user is "good,” “poor,” or "extremely poor” (step S11).
  • control unit 20 If the user's physical condition is "good” ("good” in step S11), the control unit 20 then adds 1 to the number of consecutive days of good condition stored in the memory unit 21 (step S12) and resets the number of consecutive days of poor condition to 0 (step S13).
  • control unit 20 determines whether the number of consecutive good days to which 1 was added in step S12 is equal to or greater than the good threshold (five days in the example of FIG. 4) (step S14). If the number of consecutive good days is equal to or greater than the good threshold (YES in step S14), the control unit 20 multiplies the dosage A by (1 - good condition tapering rate) to update the dosage A (step S15), and resets the number of consecutive good days stored in the memory unit 21 to 0 (step S16).
  • step S14 if the number of consecutive good days is less than the good threshold ("NO" in step S14), the control unit 20 skips steps S15 and S16. In this case, the dosage A is not updated.
  • control unit 20 divides the dosage A by the ingredient content X of one tablet of the medicine and rounds up the quotient to a positive number to calculate the amount of medicine to be added Y in units of one tablet, and further multiplies the ratio of the dosage A to the ingredient amount X ⁇ Y of the medicine to be added (A/(X ⁇ Y)) by the amount of water injected C to dissolve the medicine, to determine the amount of aqueous solution to be extracted D (step S17).
  • D (A/(X ⁇ Y)) ⁇ C
  • control unit 20 then adds 1 to the number of consecutive days of unwellness stored in the memory unit 21 (step S21) and resets the number of consecutive days of good condition to 0 (step S22).
  • control unit 20 determines whether the number of consecutive days of illness to which 1 was added in step S21 is equal to or greater than the illness threshold (3 days in the example of FIG. 4) (step S23). If the number of consecutive days of illness is equal to or greater than the illness threshold (YES in step S23), the control unit 20 multiplies the dosage A before the update by (1 + the dosage increase rate during illness) to update the dosage A (step S24), and resets the number of consecutive days of illness stored in the memory unit 21 to 0 (step S25).
  • step S23 if the number of consecutive days of illness is less than the illness threshold ("NO" in step S23), the control unit 20 skips steps S24 and S25. In this case, the dosage A is not updated.
  • control unit 20 determines the amount of medicine Y to be added and the amount of aqueous solution D to be extracted (step S17).
  • control unit 20 then resets the number of consecutive poor days stored in the memory unit 21 to 0 (step S31), and resets the number of consecutive good days to 0 (step S32).
  • control unit 20 multiplies the current dosage A by (1 + the dosage increase rate during illness) to update the dosage A (step S33).
  • control unit 20 determines the amount of medicine Y to be added and the amount of aqueous solution D to be extracted (step S17).
  • the amount of medicine Y to be added is calculated in units of one tablet, so that the user can easily add medicine.
  • the amount of medicine Y to be added may be calculated in units of 1/2 tablet or 1/4 tablet.
  • the dosage A and the amount of aqueous solution extracted D may be rounded off to a predetermined place (for example, 0.01 place) depending on the accuracy of the measuring device 24, the water injection pump 26, and the extraction pump 27.
  • control unit 20 then causes the touch panel display 11 to display the medicine input instruction screen 1200 (FIG. 7) reflecting the medicine input amount calculated in the medicine input amount calculation process and the medicine input amount Y (step S4).
  • FIG. 7 shows an example of the display of the medicine input instruction screen 1200.
  • the medicine input instruction screen 1200 displays a message indicating the dosage calculated in the dosage calculation process (e.g., "This medicine is 0.38 mg"), a message indicating the amount of medicine to be input Y (e.g., "Place the cup, add two tablets of 0.25 mg brotizolam, and press OK"), an "OK” button 1201, and a "Back” button 1202.
  • the message indicating the dosage and the message indicating the amount of medicine to be input Y may be output as audio from a speaker.
  • the amount of aqueous solution extracted D may also be displayed on the medicine input instruction screen 1200, or output as audio.
  • the "OK” button 1201 is used by the user who has placed the cup 1 under the medicine inlet 14 and inserted medicine into the medicine inlet 12 to instruct the process to proceed.
  • the "Back” button 1202 is used to return the process to step S2, display the home screen 1100, and redo the selection and input of physical condition.
  • the control unit 20 when the user operates the "OK" button 1201 on the medicine input instruction screen 1200 displayed on the touch panel display 11, the control unit 20 then causes the weighing device 24 to start weighing, and while referring to the weighing result, controls the water injection pump 26 to inject a predetermined amount C (e.g., 100 ml) of water from the water supply tank 13 into the stirring vessel 23.
  • the control unit 20 also causes the medicine crushing mechanism 22 to crush the medicine tablets and discharge them into the stirring vessel 23, and causes the stirring mechanism 25 to stir the water and medicine to create an aqueous solution.
  • the control unit 20 causes the touch panel display 11 to display the aqueous solution preparation screen 1300 (FIG. 8) (step S4).
  • FIG. 9 shows an example of a medication instruction screen 1400.
  • the medication instruction screen 1400 displays a message encouraging the user to take the medicine (for example, "Medicine extraction has been completed. Please take all of the medicine in the cup (76 ml)."), a "Home” button 1401, and a "History” button 1402.
  • the message encouraging the user to take the medicine may be output as audio.
  • FIG. 13 shows an example of the configuration of a medication reduction support device 10'. Note that components common to the medication reduction support device 10' and the medication reduction support device 10 are given the same reference numerals and their description will be omitted.
  • the administrator terminal 70 is, for example, a PC, a smartphone, etc., and is used by an administrator such as a doctor or a pharmacist who manages prescriptions for patients.
  • the administrator terminal 70 connects to the server 80 via the network N, and sets the medication setting information 211 for the patient (the user of the user terminal 60).
  • the management setting information included in the medication setting information 211 must be set in advance to enable remote control by the administrator.
  • the server 80 is a so-called cloud storage or the like, and manages medication setting information 211 and medication history information 212 corresponding to each patient.
  • the user terminal 60 accepts input of the user's physical condition, and refers to medication setting information 211 managed by the server 80 to determine the dosage A, the amount of medicine to be added Y, and the amount of aqueous solution to be extracted D.
  • the user terminal 60 instructs the user to add medicine to the medication reduction support device 10' and place the cup 1 under the medicine inlet 14, and transmits the amount of water to be added C and the amount of aqueous solution to be extracted D to the medication reduction support device 10'.
  • the medication reduction support device 10' then prepares an aqueous solution in which the medicine has been dissolved, and extracts only the amount of extraction D into the cup 1.
  • the medication reduction support system 100 allows an administrator to remotely manage the medication of multiple users.
  • the medication reduction support device 10' can be manufactured at a lower cost than the medication reduction support device 10 ( Figure 2).
  • the medication dosage determination function may be transferred from the user terminal 60 to the server 80 .
  • the dispensing function may be omitted, and only the UI function and the dosage determination function may be provided.
  • the medication reduction support device 10' may be omitted. That is, in the medication reduction support device 10 and the medication reduction support system 100, the UI function may accept input of the user's physical condition, and the dosage determination function may determine the dosage and extraction amount based on the user's physical condition and notify the user, and the user may then prepare water and cups, stir the medicine, extract it, clean up, etc., by themselves.
  • the components related to the dispensing function may be omitted or simplified.
  • some of the components related to the dispensing function may be omitted or simplified.
  • the medication reduction support system 100 according to the second embodiment some of the components of the medication reduction support device 10' may be omitted or simplified.
  • the water supply tank 13, water injection pump 26, and sensor 29 may be omitted, and the user may inject water by himself.
  • the drug crushing mechanism 22 may be omitted, and the user may crush the tablets by himself.
  • the extraction pump 27 may be omitted, and the user may extract the aqueous solution by himself.
  • the drainage tank 15, drainage pump 28, and sensor 30 may be omitted, and the user may discharge the aqueous solution by himself.
  • a specific web server can be accessed via a browser on a user terminal such as a smartphone, and when the user inputs their physical condition on a web screen displayed on the browser by the web server, the dosage, amount of medicine to be administered, and amount of aqueous solution to be extracted according to the user's physical condition can be displayed.
  • the above-mentioned configurations, functions, processing units, processing means, etc. may be realized in part or in whole in hardware, for example by designing them as integrated circuits.
  • the above-mentioned configurations, functions, etc. may also be realized in software by a processor interpreting and executing a program that realizes each function.
  • Information such as the program, table, file, etc. that realizes each function can be stored in a memory, a recording device such as a hard disk or SSD, or a recording medium such as an IC card, SD card, DVD, etc.
  • the control lines and information lines shown are those that are considered necessary for the explanation, and do not necessarily show all control lines and information lines in the product. In reality, it can be considered that almost all configurations are connected to each other.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Public Health (AREA)
  • Medical Treatment And Welfare Office Work (AREA)

Abstract

La présente invention détermine une dose appropriée d'un médicament à diminuer progressivement sur la base de l'état physique d'un patient.　L'invention concerne un dispositif d'aide à la diminution progressive de médicament pour aider à diminuer progressivement un médicament pour un utilisateur qui prend un médicament, le dispositif d'aide à la diminution progressive de médicament comprenant : une unité d'entrée qui reçoit une entrée d'un état physique de l'utilisateur ; une unité de détermination qui détermine une dose sur la base de l'état physique de l'utilisateur, détermine une quantité d'entrée du médicament sur la base de la dose déterminée, et détermine une quantité d'extraction d'une solution aqueuse dans laquelle la dose déterminée du médicament a été dissoute ; et une unité de sortie qui délivre la dose déterminée et/ou la quantité d'entrée du médicament et/ou la quantité d'extraction de la solution aqueuse.
PCT/JP2024/025117 2023-10-04 2024-07-11 Dispositif d'aide à la diminution progressive de médicament, procédé d'aide à la diminution progressive de médicament, programme et système d'aide à la diminution progressive de médicament Pending WO2025074704A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2023172759A JP2025063499A (ja) 2023-10-04 2023-10-04 減薬支援装置、減薬支援方法、プログラム、及び減薬支援システム
JP2023-172759 2023-10-04

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WO2025074704A1 true WO2025074704A1 (fr) 2025-04-10

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3631744B2 (ja) * 2002-04-09 2005-03-23 松下電器産業株式会社 健康管理システム及び健康管理方法
WO2017217226A1 (fr) * 2016-06-13 2017-12-21 ソニー株式会社 Dispositif de traitement d'informations, procédé de traitement d'informations, et programme
WO2020036231A1 (fr) * 2018-08-17 2020-02-20 レジメンキット株式会社 Procédé de gestion de médicament pour formulation en kit nécessitant un ajustement de dose

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3631744B2 (ja) * 2002-04-09 2005-03-23 松下電器産業株式会社 健康管理システム及び健康管理方法
WO2017217226A1 (fr) * 2016-06-13 2017-12-21 ソニー株式会社 Dispositif de traitement d'informations, procédé de traitement d'informations, et programme
WO2020036231A1 (fr) * 2018-08-17 2020-02-20 レジメンキット株式会社 Procédé de gestion de médicament pour formulation en kit nécessitant un ajustement de dose

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