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WO2025074368A1 - Canule pour alimentation buccale et nasale en oxygène et capnographie - Google Patents

Canule pour alimentation buccale et nasale en oxygène et capnographie Download PDF

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Publication number
WO2025074368A1
WO2025074368A1 PCT/IL2024/050977 IL2024050977W WO2025074368A1 WO 2025074368 A1 WO2025074368 A1 WO 2025074368A1 IL 2024050977 W IL2024050977 W IL 2024050977W WO 2025074368 A1 WO2025074368 A1 WO 2025074368A1
Authority
WO
WIPO (PCT)
Prior art keywords
cannula
oral
oxygen
oxygen delivery
nasal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/IL2024/050977
Other languages
English (en)
Inventor
Denis GLOZMAN
Alexander RABKIN
Shai Fleischer
Yedidia BLONDER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oridion Medical 1987 Ltd
Original Assignee
Oridion Medical 1987 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US18/828,704 external-priority patent/US20250114551A1/en
Application filed by Oridion Medical 1987 Ltd filed Critical Oridion Medical 1987 Ltd
Publication of WO2025074368A1 publication Critical patent/WO2025074368A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/091—Measuring volume of inspired or expired gases, e.g. to determine lung capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A61M16/0672—Nasal cannula assemblies for oxygen therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816—Joints or connectors
    • A61M16/0841—Joints or connectors for sampling
    • A61M16/085—Gas sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/432—Composition of exhalation partial CO2 pressure (P-CO2)

Definitions

  • the present disclosure generally relates to a capnography cannula that delivers oxygen orally and nasally and that permits sampling of exhaled carbon dioxide (CO2).
  • CO2 exhaled carbon dioxide
  • nasal cannulas are used to deliver oxygen to patients who require assistance to breathe properly, to collect carbon dioxide samples from patients to monitor respiration, or to perform both functions. Such cannulas may be used when direct ventilation is not provided.
  • a nasal cannula provides oxygen supply to the nasal cavity.
  • Some nasal cannulas have breath sampling capability such that a sample of the patient’s exhaled air flows through the cannula to a gas analyzer to be analyzed. The results of this non-invasive analysis provide an indication of the patient’s condition, such as the state of the patient’s pulmonary perfusion, respiratory system, and metabolism.
  • Capnography is the monitoring of the time-dependent respiratory carbon dioxide (CO2) concentration, which may be used to directly monitor the inhaled and exhaled concentration of CO2 and indirectly monitor the CO2 concentration in a patient's blood.
  • CO2 time-dependent respiratory carbon dioxide
  • Capnography may provide information about CO2 production, pulmonary (lung) perfusion, alveolar ventilation (alveoli are hollow cavities in the lungs in which gas exchange is being performed) and respiratory patterns.
  • Capnography may also provide information related to a patient's condition during anesthesia, for example by monitoring the elimination of CO2 from anesthesia breathing circuit and ventilator.
  • a cannula for exhaled gas monitoring and oxygen delivery includes an oxygen delivery conduit entering the cannula and an exhalation conduit exiting the cannula.
  • the cannula further includes first and second nasal prongs each comprising a channel directing exhaled nasal breath into the exhalation conduit, an oral scoop forming a cavity that is fluidly coupled to the exhalation conduit, and first and second ports fluidly coupled to the oxygen delivery conduit and opening toward the oral scoop.
  • a capnography system in another embodiment, includes a cannula that includes an oxygen delivery conduit entering the cannula, an exhalation conduit exiting the cannula, an oral scoop forming a cavity that is fluidly coupled to the exhalation conduit, and first and second oral oxygen delivery ports fluidly coupled to the oxygen delivery conduit and opening toward the oral scoop.
  • the capnography system also includes a monitor fluidly coupled to the exhalation conduit to analyze exhaled carbon dioxide received via the exhalation conduit.
  • a method of capnography includes receiving, via an oral scoop of a cannula, an exhaled breath from a patient, where the exhaled breath includes carbon dioxide, and where the oral scoop is positioned proximate an oral cavity of the patient in an installed configuration of the cannula device.
  • the method further includes directing, via a sampling line coupled to the cannula device, the exhaled breath to a gas analyzer, and delivering, via one or more oral oxygen delivery ports of the cannula device, oxygen from an oxygen source to the oral cavity of the patient while receiving the exhaled breath.
  • FIG. 1 is a schematic view of an embodiment of a capnography system, in accordance with an aspect of the present disclosure
  • FIG. 2 is a perspective view of an embodiment of a cannula which may be employed in the capnography system of FIG. 1, in accordance with an aspect of the present disclosure
  • FIG. 3A is a perspective view of an embodiment of a cannula which may be employed in the capnography system of FIG. 1, in accordance with an aspect of the present disclosure
  • FIG. 3B is a side view of an embodiment of the cannula of FIG. 3A, in accordance with an aspect of the present disclosure
  • FIG. 4A is a perspective view of an embodiment of the cannula of FIG. 3A, illustrating oxygen delivery flow paths, in accordance with an aspect of the present disclosure
  • FIG. 4B is a perspective view of an embodiment of the cannula of FIG. 3A, illustrating exhaled CO2 flow paths, in accordance with an aspect of the present disclosure
  • FIG. 5A is a perspective view of an embodiment of a cannula which may be employed in the capnography system of FIG. 1, in accordance with an aspect of the present disclosure
  • FIG. 5B is a side view of an embodiment of the cannula of FIG. 6A, in accordance with an aspect of the present disclosure
  • FIG. 6A is a perspective view of an embodiment of a cannula which may be employed in the capnography system of FIG. 1, in accordance with an aspect of the present disclosure
  • FIG. 6B is a side view of an embodiment of the cannula of FIG. 6A, in accordance with an aspect of the present disclosure
  • FIG. 7A is a perspective view of an embodiment of a cannula which may be employed in the capnography system of FIG. 1, in accordance with an aspect of the present disclosure
  • FIG. 7B is a perspective view of an embodiment of the cannula of FIG. 7A, in accordance with an aspect of the present disclosure
  • FIG. 7C is a side view of an embodiment of the cannula of FIG. 7A, in accordance with an aspect of the present disclosure
  • FIG. 8A is a perspective view of an embodiment of a cannula which may be employed in the capnography system of FIG. 1, in accordance with an aspect of the present disclosure
  • FIG. 8B is a perspective view of an embodiment of the cannula of FIG. 7A, in accordance with an aspect of the present disclosure
  • FIG. 8C is a side view of an embodiment of the cannula of FIG. 7A, in accordance with an aspect of the present disclosure
  • FIG. 9A is perspective view of an embodiment of a cannula, which may be employed in the capnography system of FIG. 1, in accordance with an aspect of the present disclosure.
  • FIG. 9B is a perspective view of an embodiment of the cannula of FIG. 9A, in accordance with an aspect of the present disclosure.
  • a nasal cannula may provide a nasal breath sample for capnography via collected exhaled gases that are collected through prongs inserted into nasal cavities.
  • the use of separate prongs for nasal exhalation sampling separates the collection of exhaled nasal gases from the actively delivered oxygen, such that the delivered oxygen does not significantly mix with the sampled nasal gases to permit more accurate measurements.
  • patients can only or primarily breathe through the mouth and may exhale through both the nasal cavity and the oral cavity.
  • sampling exhaled air through the mouth may provide a representation of respiratory function for capnography.
  • any delivered oxygen may mix with the exhaled breath from the mouth, thus diluting the gas composition and preventing accurate measurements.
  • an oral prong to capture exhaled mouth gases may be inserted into the mouth, similarly to a nasal prong, this may be uncomfortable for the patient and may interfere with the advantages of the nasal cannula, which typically permits patients to speak and eat and drink normally.
  • Certain nasal cannulas may include oxygen delivery openings that are oriented towards the mouth to provide oxygen delivery.
  • oxygen delivery arrangements are done with relatively low flow (e.g., 2-5L/minute oxygen delivery) and are not used in situations in which higher levels of oxygen delivery are needed and/or when nasal breathing is obstructed.
  • the inspiratory flow rate of the patient is greater than what is being provided by the cannula, the patient will entrain room air into the lungs. This results in oxygen dilution, and the patient will not be receiving the precise amount of oxygen that is desired.
  • an oxygen mask can provide higher levels of oxygen delivery, capnography measurements are challenging in conjunction with a mask. Accordingly, it is now recognized that improved systems and methods that enable capnometric measurement of exhaled CO2 while simultaneously providing adequate oxygenation and that may be used with higher flow oxygen delivery (e.g., up to 15L/minute) to a patient are desired.
  • Present embodiments are directed to oral/nasal cannulas that are capable of providing oxygen to both a nasal cavity of a patient and to an oral cavity of a patient, thereby providing adequate oxygenation to patients, while also being capable of sampling exhaled carbon dioxide from a nasal cavity and/or an oral cavity of the patient.
  • the cannulas disclosed herein may include an intake inlet configured to couple to an oxygen source.
  • the intake inlet may be fluidly coupled to an oxygen delivery conduit (e.g., first conduit system) configured to direct oxygen from the oxygen source to one or more oral oxygen delivery ports and to one or more nasal oxygen delivery ports.
  • the one or more oral oxygen delivery ports and the one or more nasal oxygen delivery ports may be positioned on opposite sides of the cannula to provide adequate oxygenation to a patient and, in embodiments, may provide capnography.
  • the cannula may also include an oral scoop configured to be positioned proximate an oral cavity of the patient and one or more nasal prongs configured to be inserted into a nasal cavity of the patient.
  • the oral scoop and the one or more nasal prongs may be configured to receive exhaled breath from the patient.
  • the exhaled breath may comprise exhaled carbon dioxide that is to be analyzed by a gas analyzer.
  • the oral scoop and/or the one or more nasal prongs may direct the exhaled carbon dioxide into an exhalation conduit (e.g., second conduit system) which may be fluidly coupled to a sampling outlet of the cannula.
  • the sampling outlet of the cannula may be coupled to a sampling line configured to direct the exhaled carbon dioxide to a gas analyzer coupled to an end of the sampling line opposite the end that is coupled to the sampling outlet of the cannula.
  • the oxygen delivery conduit and the exhalation conduit may be fluidly isolated from one another to ensure that oxygen delivered to a patient does not mix with exhaled carbon dioxide received from the patient.
  • a capnography system 10 is illustrated that may be used in conjunction with the disclosed oral/nasal cannulas provided herein.
  • the capnography system 10 may be utilized to sample exhaled breath from a patient 12, while providing adequate oxygenation to the patient 12.
  • the capnography system 10 may include a cannula 14 configured to provide oxygen to the patient’s nasal cavity and oral cavity during inhalation, while simultaneously capturing exhaled CO2 from the patient 12 during exhalation.
  • oxygen provided to the patient 12 via the cannula 14 may be received from an oxygen source 16.
  • the oxygen source 16 may be coupled to an oxygen line 17, and the oxygen line 17 may be coupled to the cannula 14, thereby enabling delivery of oxygen into the cannula 14.
  • the cannula 14 may include a first conduit system configured to receive the oxygen from the oxygen source 16 and deliver the oxygen to the patient 12 via one or more oral oxygen delivery ports and/or one or more nasal oxygen delivery ports, as described in greater detail below.
  • the cannula 14 may be used in conjunction with low flow oxygen delivery or high flow oxygen delivery.
  • a low flow oxygen delivery may be between 2-6 liters of oxygen per minute (L/min), while a high flow oxygen delivery may deliver oxygen at a rate above 6 L/min or, in embodiments, above 10 L/min.
  • a high flow oxygen delivery may deliver oxygen at a rate from 10 L/min- 15 L/min.
  • the oxygen delivery may be continuous flow or intermittent flow.
  • CO2 may be captured by the cannula 14 and delivered to a gas analyzer 20 for analysis via a sampling line 18.
  • the cannula 14 may include one or more nasal prongs configured to be inserted into a nasal cavity of the patient 12 and an oral scoop configured to be positioned proximate an oral cavity of the patient 12.
  • the one or more nasal prongs and the oral scoop may be fluidly coupled to a second conduit system of the cannula 14, thereby enabling capture and delivery of exhaled CO2 to the gas analyzer 20 via the sampling line 18.
  • the gas analyzer 20 e.g., capnograph
  • the gas analyzer 20 may be communicatively coupled to a computer 22 (e.g., a desktop computer, a tablet, a mobile device) or a separate display device to facilitate the display of information related to the patient’ s condition, which may include displayed CO2 measurements from the gas analyzer.
  • a computer 22 e.g., a desktop computer, a tablet, a mobile device
  • a separate display device to facilitate the display of information related to the patient’ s condition, which may include displayed CO2 measurements from the gas analyzer.
  • the system 10 may include additional or fewer components than those illustrated.
  • the gas analyzer 20 and the computer 22 may be integrated into a single unit.
  • the illustrated oxygen line 17 and/or the sampling line 18 may include one or more gas transfer conduits.
  • the oxygen line 17 may include one or more fluidically connected conduits
  • the sampling line 18 may include one or more fluidically connected conduits.
  • FIG. 2 is a perspective view of an embodiment of a cannula 45 (e.g., cannula 14) which may be employed by the capnography system 10 of FIG. 1.
  • the cannula 45 permits oral oxygen and nasal oxygen delivery (e.g., continuous oxygen delivery) and sampling of exhaled nasal gases and exhaled mouth gases via the cannula 45.
  • the cannula 45 (e.g., cannula device, oral/nasal cannula) has a patient-facing side 47 oriented toward the patient in an assembled configuration of the cannula 45, and an outer side 49 (e.g., environment-facing side) oriented away from the patient (e.g., oriented toward the environment) in the assembled configuration of the cannula 45.
  • the cannula 45 may include a housing 52 defining an interior space 53 of the cannula 45.
  • the housing 52 may be defined by a plurality of sides 54, and may include a first end 56 and a second end 58.
  • the cannula 45 includes a pair of nasal prongs 60 extending from a first side 54 (e.g., top side, upper side) of the housing 52 in a direction (e.g., upward direction) along a vertical axis 90 of the cannula 45.
  • each of the nasal prongs 60 may extend at an angle in a direction (e.g., upward direction) relative to the vertical axis 90 toward the nasal cavity of the patient (e.g., toward the patient-facing side 47) in an assembled configuration of the cannula 45.
  • the cannula 45 also includes an oral scoop 62 extending from a second side 54 (e.g., bottom side) of the housing 52 in a direction (e.g., downward direction) along the vertical axis 90 of the cannula 45.
  • the oral scoop 62 may extend at an angle in a direction (e.g., downward direction) relative to the vertical axis 90 toward an oral cavity (e.g., mouth) of the patient (e.g., toward the patient-facing side 47) in an assembled configuration of the cannula 45.
  • Each nasal prong 60 of the pair of nasal prongs 60 may be configured to be inserted into a nasal cavity of the patient when the cannula is in use with a patient (see FIG.
  • the oral scoop 62 may be configured to be positioned proximate an oral cavity (e.g., mouth) of the patient, thereby permitting the oral scoop 62 to capture exhaled breath from the oral cavity of the patient.
  • the oral scoop 62 may include a neck 63 (e.g., neck portion) extending from the housing 52 and a body portion 65 (e.g., body) which may define a cavity 66 configured to receive exhaled breath from the oral cavity of the patient, and the exhaled breath may include carbon dioxide.
  • the body 65 may include a lip portion 67 that further defines the cavity 66.
  • the lip portion 67 may at least partially extend from the neck 63 into the cavity 66.
  • the lip portion 67 may be configured to facilitate delivery of oxygen into the oral cavity of a patient and/or limit an amount of mixing between the oxygen delivered to the oral cavity of the patient and the exhaled oral breath received from the patient, as discussed in greater detail below.
  • the body 65 of the oral scoop 62 is illustrated as having a pentagonal shape, the body 65 of the oral scoop 62 may take on other shapes including square, triangular, circular, ovoidal or any other suitable shape without departing from the scope of this disclosure.
  • the scoop 62 is configured to at least in part contact the patient when the cannula 45 is in use.
  • the first end 56 of the housing 52 may include an intake inlet 68 fluidly coupled to the oxygen source 16 via the oxygen line 17.
  • the second end 58 of the housing 52 may include a sampling outlet 70 fluidly coupled to the gas analyzer 20 via the sampling line 18.
  • the intake inlet 68 and the sampling outlet 70 may be fluidly coupled to respective conduit systems (see FIG. 3A and FIG. 3B, for example) disposed within the interior space 53 defined by the housing 52.
  • the intake inlet 68 may be fluidly coupled to an oxygen delivery conduit (e.g., first conduit system) entering the cannula 45 and configured to direct oxygen from the oxygen source 16 toward one or more oral oxygen delivery ports and to one or more nasal oxygen delivery ports, as described in greater detail below.
  • an oxygen delivery conduit e.g., first conduit system
  • the intake inlet 68 and the sampling outlet 70 may include suitable couplings or connectors to permit reversible attachment of conduits (e.g., tubing) to permit transfer of gases from the oxygen supply 16 and to the gas analyzer 20.
  • the one or more oral oxygen delivery ports may be configured to direct the oxygen in a direction (e.g., downward direction) along the vertical axis 90 of the cannula 45 toward the oral scoop 62 and toward the oral cavity of the patient.
  • the one or more nasal oxygen delivery ports may be configured to direct the oxygen in a direction (e.g., upward direction) along the vertical axis 90 toward the nasal cavity of the patient.
  • the sampling outlet 70 may be fluidly coupled to an exhalation conduit (e.g., second conduit system) within the interior space 53 that is configured to receive exhaled breath from the nasal cavity of the patient via the nasal prongs 60 and/or from the oral cavity of the patient via the oral scoop 62.
  • the channels 64 defined by the nasal prongs 60 may be fluidly coupled to the exhalation conduit such that as a patient exhales through the nasal cavity, the channels 64 may direct the exhaled nasal breath into the exhalation conduit.
  • the exhalation conduit may deliver the exhaled nasal breath toward the sampling outlet 70, which may then direct the exhaled nasal breath to the gas analyzer 20 via the sampling line 18.
  • the cavity 66 defined by the oral scoop 62 may also be fluidly coupled to the exhalation conduit, thereby enabling exhaled oral breath from the patient to be directed from the oral scoop 62, into the exhalation conduit, and through the sampling outlet 70 toward the gas analyzer 20 via the sampling line 18.
  • Each of the oxygen delivery conduit and the exhalation conduit may be fluidly isolated from one another, thereby limiting an amount of mixing between the oxygen delivered to the patient and the exhaled carbon dioxide received from the patient. In this way, the accuracy of the analysis performed by the gas analyzer 20 may be improved.
  • the sampling line 18 may be coupled to a suction source 72 (e.g., pump) configured to entrain exhaled breath into the sampling line 18.
  • the suction source 72 may be a pump configured to draw exhaled breath through the exhalation conduit, out of the sampling outlet 70, and toward the gas analyzer 20.
  • the cannula 45 is a unitary structure.
  • the cannula 45 may be a molded or formed piece.
  • the cannula 45 may be assembled from component parts.
  • the cannula housing 52 may be silicon, rubber, plastic, other polymeric material, metal, or any other suitable material(s).
  • FIGS. 3A and 3B illustrate an embodiment of a cannula 100 (e.g., cannula 14, cannula 45) configured to deliver oxygen to a patient’s oral and nasal cavities and receive exhaled carbon dioxide from the patient’s oral and nasal cavities.
  • the cannula 100 may include similar features to the cannula 45.
  • the cannula 100 may include the plurality of sides 54 that define the housing 52 and the interior space 53, the first end 56, the second end 58, the nasal prongs 60, the oral scoop 62, the channels 64, the body 65, the cavity 66, the lip portion 67, the intake inlet 68 disposed at the first end 56 of the housing 52, and the sampling outlet 70 disposed at the second end 58 of the housing 52.
  • the cannula 100 may include an oxygen delivery conduit 102 (e.g., first conduit system, oxygen delivery conduit system) fluidly coupled to the intake inlet 68 and configured to receive oxygen from the oxygen source 16.
  • the oxygen delivery conduit 102 may include one or more different conduits configured to direct oxygen to an oral and/or nasal cavity of a patient.
  • the oxygen delivery conduit 102 may include a primary conduit 104 (e.g., main conduit, body conduit) and a plurality of secondary conduits 106 that each terminate at an oxygen delivery port 108.
  • a first set of the secondary conduits 106 may extend in a direction (e.g., upward direction) along the vertical axis 90 toward a nasal cavity of the patient, while a second set of the secondary conduits 106 may extend in a direction (e.g., downward direction) along the vertical axis toward an oral cavity of the patient.
  • the oxygen delivery ports 108 associated with the first set of secondary conduits 106 may correspond to nasal oxygen delivery ports 110 opening away from the oral scoop 62
  • the oxygen delivery ports 108 associated with the second set of secondary conduits 106 may correspond to oral oxygen delivery ports 112 opening toward the oral scoop 62.
  • each of the secondary conduits 106 and the oxygen delivery ports may extend at a respective angle (e.g., non-zero angle) relative to the vertical axis 90 (e.g., in a direction along a longitudinal axis 94 of the cannula 100 toward the oral cavity and nasal cavity of the patient).
  • a respective angle e.g., non-zero angle
  • Each of the oxygen delivery ports 108 may be sized and configured to enable appropriate distribution of oxygen to the patient.
  • the oxygen delivery ports 108 may be sized and configured such that fifty percent of the oxygen received from the oxygen source 16 is delivered to the nasal cavity of the patient, while the remaining fifty percent of the oxygen received from the oxygen source 16 is delivered to the oral cavity of the patient, thereby providing adequate oxygenation to the patient.
  • other distributions are also contemplated.
  • each of the nasal oxygen delivery ports 110 may be sized and configured relative to one another to enable appropriate distribution (e.g., symmetrical distribution) through each of the nasal oxygen delivery ports 110 and each of the oral oxygen delivery ports 112 may be sized and configured relative to one another to enable appropriate distribution (e.g., symmetrical distribution) through each of the oral oxygen delivery ports 112, as discussed in greater detail below.
  • two nasal oxygen delivery ports 110 are illustrated, it should be understood that more or fewer ports 110 may be used. In an embodiment, one, two, three, four, five or more ports 110 may be present on the cannula 100.
  • two oral oxygen delivery ports 112 are illustrated, it should be understood that more or fewer ports 112 may be used. In an embodiment, one, two, three, four, five or more ports 112 may be present on the cannula 100.
  • the cannula 100 may also include an exhalation conduit 114 (e.g., second conduit system, exhalation conduit system) exiting the cannula 100 and configured to receive exhaled breath from the nasal cavity and the oral cavity of the patient. Similar to the oxygen delivery conduit 102, the exhalation conduit 114 may include one or more different conduits extending in different directions to facilitate collection of exhaled breath from the patient’s oral and/or nasal cavities.
  • exhalation conduit 114 e.g., second conduit system, exhalation conduit system
  • the exhalation conduit 114 may include a primary conduit 116 extending in a direction (e.g., horizontal direction) along a lateral axis 92 of the cannula 100, a pair of secondary conduits 118 extending in a direction (e.g., upward direction) along the vertical axis 90 of the cannula 45, and an additional secondary conduit 120 extending in a direction (e.g., downward direction) along the vertical axis 90 of the cannula 100.
  • the first set of secondary conduits 118 may be configured to extend through the channels 64 of the nasal prongs 60, and thus, may be configured to receive nasal exhaled breath from the patient and deliver the nasal exhaled breath to the primary conduit 116 of the exhalation conduit 114.
  • the additional secondary conduit 120 may be configured to extend through the neck 63 of the oral scoop 62, thereby enabling the additional secondary conduit 120 to receive oral exhaled breath from the patient (e.g., oral exhaled breath within the cavity 66) and deliver the oral exhaled breath to the primary conduit 116 of the exhalation conduit 114.
  • the additional secondary conduit 120 may be fluidly coupled to a funnel 124 disposed within the oral scoop 62 (e.g., fluidly coupled to the cavity 66).
  • the funnel 124 may be at least partially defined by the body 65 (e.g., by the lip portion 67) of the oral scoop 62 and may be configured to facilitate collection of the oral exhaled breath from the patient for collection and delivery of exhaled breath to the gas analyzer 20 for analysis. It should be appreciated that while the secondary conduits 118 and the additional secondary conduit 120 are illustrated as extending directly along the vertical axis 90, in certain embodiments, each of the secondary conduits 118 and the additional secondary conduit 120 may extend at a respective angle relative to the vertical axis 90 (e.g., in a direction along the longitudinal axis 94).
  • the cannula 100 illustrated in FIGS. 3A and 3B may be configured to deliver oxygen into the oral scoop 62 during an inhalation phase of the patient.
  • each of the oral oxygen delivery ports 112 may be oriented to align with a portion of the oral scoop 62 such that oxygen directed out of the oral oxygen delivery ports 112 is directed directly into the oral scoop 62.
  • the oral scoop 62 may include one or more openings 126 disposed on an upper side of the oral scoop 62. The openings 126 may substantially align with the oral oxygen delivery ports 112 along the vertical axis 90, thereby enabling delivery of oxygen from the oral oxygen delivery ports 112 and into the cavity 66 of the oral scoop 62.
  • each of the nasal oxygen delivery ports 110 may be positioned proximate the nasal prongs 60.
  • FIGS. 3A and 3B illustrate the nasal oxygen delivery ports 110 being positioned behind the nasal prongs 60 relative to a patient-facing side 128 of the cannula 100.
  • the nasal oxygen delivery ports 110 may be positioned in front of the nasal prongs 60 relative to the patient-facing side 47 of the cannula 100, or adjacent to the nasal prongs 60, thereby enabling oxygen to be delivered into the nasal cavity of the patient.
  • the nasal oxygen delivery ports 110 may be positioned a threshold distance away from the nasal prongs 60 of the cannula 100, thereby reducing pressure within the nasal cavity of the patient during inhalation and exhalation. In this way, an amount of mixing between oxygen delivered via the nasal oxygen delivery ports 110 and nasal exhaled breath may be reduced and a patient experience may be improved. It should be appreciated that a cannula 100 having a particular nasal oxygen delivery port 110 configuration (e.g., arrangement of nasal oxygen delivery ports relative to the nasal prongs 60) may be selected for a patient based on certain physical characteristics of the patient (e.g., size of face, facial structure, facial geometry).
  • FIGS. 4A and 4B illustrate the movement of delivered gas and exhaled gas through the oral scoop 62 of the cannula 100 during inhalation and exhalation, respectively.
  • FIGS. 4A and 4B illustrate the movement of delivered gas into the scoop 62 as in the example shown in FIG. 3 A and 3B.
  • the flow of oxygen shown by arrows 130, may be delivered toward the oral scoop 62.
  • the oxygen may be delivered as part of a continuous oxygen delivery.
  • the oral scoop 62 of the cannula 100 may include openings 126 configured to align with the oral oxygen delivery ports 112 along the vertical axis 90 such that oxygen traveling out of the oral oxygen delivery ports 112 is directed through the openings 126 and into the cavity 66 of the oral scoop 62. In this way, the oxygen may be delivered to the oral cavity of the patient.
  • the oral oxygen delivery ports 112 may be configured to deliver oxygen at a desired flow rate into the cavity 66 of the oral scoop 62, as described in greater detail below.
  • the desired flow rate of oxygen through the oral oxygen delivery ports 112 may be based on an expected pressure or flow of an exhaled breath from an oral cavity of the patient.
  • FIG. 4B illustrates the redirection of the flow of oxygen 130 relative to the scoop 66 as a patient exhales.
  • the flow of oxygen 130 from the oral oxygen delivery ports 112 may be overcome by a pressure of the exhaled breath 131 from the patient.
  • oxygen may be pushed or redirected out of the oral scoop 62 by the patient’s exhaled breath 131. That is, the pressure of exhaled breath 131 from the patient’s oral cavity may be greater than the pressure oxygen delivered to the oral cavity of the patient via the oral oxygen delivery ports 112.
  • any oxygen which may be present within the oral scoop 62 during an exhalation phase of a patient may be redirected or biased out of the oral scoop 62, thereby limiting dilution of the exhaled breath 131 received by the exhalation conduit 114 and delivered to the gas analyzer 20.
  • the sampled exhaled breath 131 does not mix with incoming delivered oxygen during exhalation.
  • oxygen influx into the scoop 62 is temporarily overcome by the exhaled breath 131 pushing the oxygen out and around the scoop 62. This serves to separate the sampled exhaled breath 131 from the incoming flow of oxygen 130, permitting sampling of exhaled breath 131 from the mouth while simultaneously delivering oxygen towards the mouth.
  • FIGS. 5A and 5B illustrate an embodiment of a cannula 200 (e.g., cannula 14, cannula 45) configured to deliver oxygen to a patient’s oral and nasal cavities.
  • the cannula 200 may include similar features to the cannula 45.
  • the cannula 200 may include the plurality of sides 54 that define the housing 52 and the interior space 53, the first end 56, the second end 58, the nasal prongs 60, the oral scoop 62, the channels 64, the body 65, the cavity 66, the lip portion 67, the intake inlet 68 disposed at the first end 56 of the housing 52, and the sampling outlet 70 disposed at the second end 58 of the housing 52.
  • the cannula 200 may also include the exhalation conduit 114 (e.g., second conduit system, exhalation conduit system) configured to receive exhaled breath from the patient’s oral and nasal cavities and direct the exhaled breath to the gas analyzer 20 via the sampling line 18.
  • the cannula 200 may also include the primary conduit 116, the first set of secondary conduits 118 extending through the channels 64 of the nasal prongs 60, the additional secondary conduit 120 extending through the neck 63 of the oral scoop 62, the funnel 124, and the openings 126.
  • the cannula 200 may also include a pair of slides 202 (e.g., plates) extending from the housing 52 toward the oral scoop 62. As illustrated in FIG. 5B, the slides 202 may be oriented at an angle 204 (e.g., non-zero angle) relative to the vertical axis 90 of the cannula 200, such that oxygen directed from the oral oxygen delivery ports 112 in a direction (e.g., downward direction) along the vertical axis 90 may impinge upon the slides 202 and be directed at an angle toward (e.g., across) the scoop 62 and toward the oral cavity of the patient.
  • an angle 204 e.g., non-zero angle
  • oxygen directed from the oral oxygen delivery ports 112 may be directed across a portion of the oral scoop 62 instead of being directed directly into the oral scoop 62. That is, by employing the slides 202, oxygen delivered via the oral oxygen delivery ports 112 may be directed at least partially along the longitudinal axis 94 toward the oral cavity of the patient, and an amount of oxygen entrained into the exhalation conduit 114 may be limited during an exhalation phase of the patient.
  • the slides 202 may be configured to reduce a flow rate or velocity of the oxygen directed out of the oral oxygen delivery ports 112.
  • the flow rate or pressure of the patient’s exhaled breath may more easily bias oxygen away from the oral scoop 62 and/or the exhalation conduit 114, thereby limiting an amount of dilution of the exhaled breath entrained into the exhalation conduit 114. That is, by reducing the flow rate of oxygen using the slides 202, redirection of the oxygen via the patient’ s exhaled breath may be more easily achieved due to the reduced flow rate or velocity of the oxygen from the oral oxygen delivery ports 112.
  • FIGS. 6A and 6B illustrate an embodiment of a cannula 300 (e.g., cannula 14, cannula 45) configured to deliver oxygen to a patient’s oral and nasal cavities and having a closed scoop arrangement in which oxygen is routed outside of the scoop 62.
  • the cannula 300 may include similar features to the cannula 45.
  • the cannula 300 may include the plurality of sides 54 that define the housing 52 and the interior space 53, the first end 56, the second end 58, the nasal prongs 60, the oral scoop 62, the channels 64, the body 65, the cavity 66, the lip portion 67, the intake inlet 68 disposed at the first end 56 of the housing 52, and the sampling outlet 70 disposed at the second end 58 of the housing 52.
  • the cannula 300 may include similar features to the cannula 100.
  • the cannula 300 may include the oxygen delivery conduit 102 (e.g., second conduit system, oxygen delivery conduit system) configured to receive oxygen from the oxygen source 16 and deliver the oxygen to the patient’s oral and nasal cavities.
  • the cannula 300 may include the primary conduit 104, the first set of secondary conduits 106 extending toward the nasal cavity of the patient, the second set of secondary conduits 106 extending toward the oral cavity of the patient, and the plurality of oxygen delivery ports 108, including the nasal oxygen delivery ports 110 and the oral oxygen delivery ports 112.
  • the cannula 300 may also include the exhalation conduit 114 (e.g., second conduit system, exhalation conduit system) configured to receive exhaled breath from the patient’ s oral and nasal cavities and direct the exhaled breath to the gas analyzer 20 via the sampling line 18.
  • the cannula 300 may also include the primary conduit 116, the first set of secondary conduits 118 extending through the channels 64 of the nasal prongs 60, the additional secondary conduit 120 extending through the neck 63 of the oral scoop 62, and the funnel 124.
  • the oral oxygen delivery ports 112 of the cannula 300 may not align with the oral scoop 62 in a direction along the vertical axis 90 of the cannula 300. Instead, the oral oxygen delivery ports 112 of the cannula 300 may be oriented such that oxygen directed out of the oral oxygen delivery ports 112 is directed around or outside of the oral scoop 62 instead of into the oral scoop 62. For example, as illustrated in FIG. 6A, each of the oral oxygen delivery ports 112 may be offset along the lateral axis 92 of the cannula 300 relative to the oral scoop 62 such that oxygen is delivered around the oral scoop and into the oral cavity of the patient.
  • the oral oxygen delivery ports 112 of the cannula 300 are not configured to direct oxygen into the oral scoop 62, the oral scoop 62 of the cannula 300 may not include the openings 126 (see FIGS. 3A, 5A). By directing the oxygen around the oral scoop 62, the cannula 300 may limit an amount of dilution of the exhaled breath received by the exhalation conduit 114.
  • FIG. 6B is a side view showing oxygen delivery.
  • the oxygen in FIG. 6B is shown as being delivered downward and around the scoop 62.
  • the oxygen delivery ports 112 are also offset from the nasal delivery ports 110 along the lateral axis 92.
  • the oxygen delivery ports 112 flank the nasal delivery ports 110, such that the nasal delivery ports 110 are positioned between the oxygen delivery ports 112, which are closer to the respective ends 56, 58 of the cannula 300.
  • the oxygen delivery ports 112 may be positioned relatively closer to the ends 56, 58 to ensure that the scoop 62 does not obstruct oxygen delivery.
  • the cannula 400 may include similar features to the cannulas 100, 200, and 300.
  • the cannula 400 may include the oxygen delivery conduit 102 (e.g., second conduit system, oxygen delivery conduit system) configured to receive oxygen from the oxygen source 16 and deliver the oxygen to the patient’s oral and nasal cavities.
  • the cannula 400 may include the primary conduit 104, the first set of secondary conduits 106 extending toward the nasal cavity of the patient, the second set of secondary conduits 106 extending toward the oral cavity of the patient, and the plurality of oxygen delivery ports 108, including the nasal oxygen delivery ports 110 and the oral oxygen delivery ports 112.
  • the cannula 400 may also include the exhalation conduit 114 (e.g., second conduit system, exhalation conduit system) configured to receive exhaled breath from the patient’ s oral and nasal cavities and direct the exhaled breath to the gas analyzer 20 via the sampling line 18.
  • the cannula 200 may also include the primary conduit 116, the first set of secondary conduits 118 extending through the channels 64 of the nasal prongs 60, the additional secondary conduit 120 extending through the neck 63 of the oral scoop 62, and the funnel 124.
  • each lobe portion 406 may be oriented at an angle relative to the vertical axis 90 (e.g., in a direction toward the oral cavity of the patient) such that oxygen delivered via the oral oxygen delivery ports 112 may be directed toward the oral cavity of the patient.
  • a length of the slides 402 may be less than a length of the slides 202, and the angle 404 at which the slides 402 extend relative to the vertical axis 90 may be greater than the angle 202 at which the slides 202 extend relative to the vertical axis 90.
  • features of the cannula 500 may be composed of different materials having different characteristics (e.g., elasticity, stiffness).
  • components that interface with (e.g., contact, directly contact) the patient, such as the protrusion 504 may be composed of a material having a lower stiffness relative to the material of the plurality of sides 54. In this way, an amount of support and/or comfort may be increased relative to traditional cannulas.
  • the flow rate and velocity of the oxygen directed through the oral oxygen delivery ports 112 and the nasal oxygen delivery ports 110 may be controlled to permit generally symmetrical distribution of oxygen flow via asymmetrically-sized and spaced apart nasal and oral oxygen delivery ports 110, 112.
  • the difference in size between the ports 112 A, 112B and/or a difference in size between the ports 110A, HOB may be a total area of first oral oxygen delivery port 112A or the first nasal oxygen delivery port 110A relative to the second oral oxygen delivery port 112B or the second nasal oxygen delivery port HOB, respectively.
  • symmetrical distribution of oxygen between a respective type of oxygen delivery port e.g., symmetrical distribution between nasal oxygen delivery ports 110A and HOB, symmetrical distribution of oxygen between oral oxygen delivery ports 112A and 112
  • a respective type of oxygen delivery port e.g., symmetrical distribution between nasal oxygen delivery ports 110A and HOB, symmetrical distribution of oxygen between oral oxygen delivery ports 112A and 112
  • the flow rate of oxygen within the oxygen delivery conduit 102 may cause the flow of oxygen to bypass the first oral oxygen delivery port 112A and travel toward a distal end (e.g., end of the oxygen delivery conduit proximate the second end 58 of the housing 52) of the oxygen delivery conduit 102.
  • a first portion of the oxygen may be discharged out of the oxygen delivery conduit 102 via the second oral oxygen delivery port 112B.
  • a second portion of the oxygen may impinge against the inner walls of the oxygen delivery conduit 102 before being redirected in an upstream direction (e.g., relative to the flow of oxygen into the oxygen delivery conduit 102), thereby creating turbulence and/or an increase in pressure within the oral oxygen delivery conduit 102.
  • the turbulence and/or increase in pressure may enable some oxygen to be discharged from the oral oxygen delivery conduit 102 via the first oral oxygen delivery port 112A.
  • the flow rates between similarly sized ports 112A, 112B may diverge as a result of the flow dynamics within the oxygen delivery conduit 102. It should be appreciated that the same fluid flow dynamics discussed above may apply to similarly sized nasal oxygen delivery ports 110.
  • a decreased amount of oxygen may bypass the first oral oxygen delivery port 112A (e.g., relative to an embodiment in which the oral oxygen delivery ports 112 are similarly sized), and instead, may be delivered to the patient via the first oral oxygen delivery port 112A.
  • a pressure within the oral oxygen delivery conduit 102 may decrease, thereby decreasing an amount of turbulence within the oral oxygen delivery conduit 102.
  • symmetrical (e.g., substantially symmetrical) distribution of oxygen between the oral oxygen delivery ports 112 may be more readily achievable. It should be appreciated that the same fluid flow dynamics discussed above may apply to the nasal oxygen delivery ports 110A, 110B.
  • Example 8 The cannula of Example 1, wherein the first and second ports are offset from the oral scoop along a vertical axis of the cannula such that oxygen is delivered outside of the oral scoop.
  • Example 9 The cannula of Example 1, wherein the first and second ports are first and second oral oxygen delivery ports, and wherein the cannula comprises first and second nasal oxygen delivery ports fluidly coupled to the oxygen delivery conduit and opening away from the oral scoop.
  • Example 13 The capnography system of Example 11, wherein the first and second oral oxygen delivery ports deliver oxygen into the oral scoop.
  • Example 18 The capnography system of Example 11, wherein the cannula comprises: first and second nasal oxygen delivery ports fluidly coupled to the oxygen delivery conduit, wherein the first nasal oxygen delivery port is a different size than the second nasal oxygen delivery port.
  • Example 19 A method of capnography, comprising: receiving, via an oral scoop of a cannula, an exhaled breath from a patient, wherein the exhaled breath comprises carbon dioxide, and wherein the oral scoop is positioned proximate an oral cavity of the patient in an installed configuration of the cannula device; directing, via a sampling line coupled to the cannula device, the exhaled breath to a gas analyzer; and delivering, via first and second oral oxygen delivery ports of the cannula device, oxygen from an oxygen source to the oral cavity of the patient while receiving the exhaled breath.

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Abstract

Une canule pour la surveillance de gaz expiré et la distribution d'oxygène comprend un conduit de distribution d'oxygène entrant dans la canule et un conduit d'expiration sortant de la canule. La canule comprend en outre des première et seconde broches nasales comprenant chacune un canal dirigeant l'haleine nasale expirée dans le conduit d'expiration, un élément de type pelle buccale formant une cavité qui est en communication fluidique avec le conduit d'expiration, et des premier et second orifices en communication fluidique avec le conduit de distribution d'oxygène et s'ouvrant vers l'élément de type pelle buccale.
PCT/IL2024/050977 2023-10-04 2024-10-02 Canule pour alimentation buccale et nasale en oxygène et capnographie Pending WO2025074368A1 (fr)

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US202363542446P 2023-10-04 2023-10-04
US63/542,446 2023-10-04
US202463664994P 2024-06-27 2024-06-27
US63/664,994 2024-06-27
US18/828,704 2024-09-09
US18/828,704 US20250114551A1 (en) 2023-10-04 2024-09-09 Cannula for oral and nasal oxygen supply and capnography

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070272247A1 (en) * 2006-04-25 2007-11-29 Oridion Medical Ltd. Oral nasal cannula
US20200009344A1 (en) * 2018-07-09 2020-01-09 Oridion Medical 1987 Ltd. Facially fitting devices with illuminated placement markers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070272247A1 (en) * 2006-04-25 2007-11-29 Oridion Medical Ltd. Oral nasal cannula
US20200009344A1 (en) * 2018-07-09 2020-01-09 Oridion Medical 1987 Ltd. Facially fitting devices with illuminated placement markers

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