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WO2025072489A3 - Analogues of n-lactoyl-phenylalanine, methods of synthesis, and methods of use - Google Patents

Analogues of n-lactoyl-phenylalanine, methods of synthesis, and methods of use Download PDF

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Publication number
WO2025072489A3
WO2025072489A3 PCT/US2024/048617 US2024048617W WO2025072489A3 WO 2025072489 A3 WO2025072489 A3 WO 2025072489A3 US 2024048617 W US2024048617 W US 2024048617W WO 2025072489 A3 WO2025072489 A3 WO 2025072489A3
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WIPO (PCT)
Prior art keywords
methods
analogues
lactoyl
phenylalanine
synthesis
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PCT/US2024/048617
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French (fr)
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WO2025072489A2 (en
Inventor
Alan T. Remaley
Anna WOLSKA
Amaury Lucien Philip DASSEUX
Denis SVIRIDOV
Marcelo J. AMAR
Rolf E. Swenson
Eric Jorgen LINDBERG
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US Department of Health and Human Services
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US Department of Health and Human Services
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract

N-Lactoyl-Phenylalanine (Lac-Phe) analogues are disclosed having activity as appetite suppressants useful as therapeutics in the treatment of obesity and related secondary diseases. Methods of synthesis of the N-Lactoyl-Phenylalanine (Lac-Phe) analogues are also disclosed, as well as methods of use and treatment with the Lac-Phe analogues.
PCT/US2024/048617 2023-09-27 2024-09-26 Analogues of n-lactoyl-phenylalanine, methods of synthesis, and methods of use Pending WO2025072489A2 (en)

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US202363585791P 2023-09-27 2023-09-27
US63/585,791 2023-09-27

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WO2025072489A3 true WO2025072489A3 (en) 2025-05-01

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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