WO2025061651A1

WO2025061651A1 - Infusion device with a differential transmission

Info

Publication number: WO2025061651A1
Application number: PCT/EP2024/075849
Authority: WO
Inventors: Remy Wolff
Original assignee: Fresenius Vial SAS
Current assignee: Fresenius Vial SAS
Priority date: 2023-09-18
Filing date: 2024-09-17
Publication date: 2025-03-27
Anticipated expiration: 2026-03-18

Abstract

An infusion device (1) for administering a medical fluid to a patient comprises: a housing (10) having a receptacle (100) for receiving a syringe (2), a pusher device (11) which is movable for acting onto a piston (21) of a syringe (2) received on the receptacle (100), and a drive mechanism (D) for driving the pusher device (11) and comprising: an electric drive (14), and a brake device (15) having a brake element (151), wherein a motion of the brake element (151) is braked in a brake state of the brake device (15) and released in a release state of the brake device (15), wherein the drive mechanism (D) further comprises a differential transmission (16) via which the pusher device (11) is operatively connected with the electric drive (14) and the brake element (151).

Description

Infusion Device with a Differential Transmission

Description

The invention relates to an infusion device for administering a medical fluid to a patient.

Infusion pumps loadable with a syringe, also known as syringe pumps, allow very precise infusion processes and provide a visible indicator of the progress of the infusion. Therein, commonly a pusher device is driven by a drive mechanism to push a piston of a loaded syringe into its barrel.

To easily load or exchange a syringe, however, relatively complex drive mechanisms can be applied, e.g., with one or more clutches to decouple a drive motor so that the pusher device can be manually moved freely.

In one option which can be referred to as fully manual loading, the pusher device can be unclutched from a leading screw during the installation of a syringe by a manual actuation of a lever or button on the pusher. A disadvantage of such a solution is that the syringe loading relies on the carefulness of the user. This can be improved by adding a braking device to stop the translation of the pusher device when approaching the syringe piston, however, with the drawback of an again more complex design.

Another option can be referred to as fully automatic loading. Therein, the pusher device remains linked to a leading screw by a fixed nut. For installing or removing a syringe the pusher device is actuated at the highest possible speed. This allows a simple drive mechanism. However, the resulting loading time would be very long. Furthermore, when the infusion device is unpowered, the pusher device is not operable, and an installed syringe cannot be detached from the infusion device.

From EP 0 916 353 B1 an infusion device in the shape of a syringe pump is known, in which a button acting on a lever is arranged on a pusher device for actuating a coupling mechanism between a coupling state and an uncoupling state.

EP 2 482 871 B1 describes a pump of the syringe driver-type comprising a casing, a syringe cradle intended to receive a syringe, a pusher device mobile relative to the casing and capable of being driven in translation parallel to the longitudinal axis of the syringe by driving means and clutch means for engaging or disengaging the pusher device on the driving means, wherein the pump is equipped with means for blocking the movement of the pusher device toward the syringe when the pusher device contacts the syringe head during a movement from a position without contact with the syringe head toward a position in contact with the syringe head. The means for blocking the push device comprises a threaded control rod, a nut engaged on the threaded control rod and integral with the pusher device, a brake acting on the threaded control rod and a contact sensor to detect the presence or the absence of contact between the pusher device and the syringe head.

It is an object of the present invention to provide an infusion device with a precise drive mechanism that allows a fast syringe installation.

This object is achieved by an infusion device having the features of claim 1.

Accordingly, an infusion device for administering a medical fluid to a patient is provided. The infusion device comprises a housing having a receptacle for receiving a syringe, a pusher device which is movable for acting onto a piston of the syringe received on the receptacle and a drive mechanism for driving the pusher device. The drive mechanism comprises an electric drive and a brake device having a brake element, wherein a motion of the brake element is braked in a brake state of the brake device and released in a release state of the brake device. Therein, it is provided that the drive mechanism further comprises a differential transmission via which the pusher device is operatively connected with the electric drive and the brake element.

By using a differential transmission the brake device can be operated in the brake state to move the pusher device using the electric drive. On the other hand, the brake device can be simply operated in the release state to allow a fast manual displacement of the pusher device. Since no clutches or other releasable components are necessary, a very high precision in the operation is possible, too. Thus, an infusion device with a precise drive mechanism that allows a fast syringe installation is provided.

For example, the drive mechanism further comprises a first drive element and a second drive element. Via the first and second drive elements, the pusher device is operatively connected with the differential transmission. The second drive element may be (e.g., firmly) connected with the pusher device and/or displaceable with respect to the first drive element by a motion of the first drive element (e.g., with respect to the housing). The electric drive may be configured for driving the first drive element via the transmission. This allows a simple and reliable, yet precise drive.

The transmission may comprise a first gear element, a second gear element and/or a third gear element. Therein, the third gear element may be in toothed engagement with the first gear element and/or with the second gear element. This allows an efficient and small transmission.

For example, the first gear element is configured to be driven by the electric drive and/or to drive the third gear when being driven by the electric drive. This allows to couple the electric drive to the brake device and the pusher device via a small number of parts.

A belt may be provided which operatively connects the electric drive with the first gear element. In this manner, the electric drive can be located further displaced than with a geared connection. In addition, the belt allows a high transmission ratio.

The third gear element may be rotatably mounted on a carrier. The carrier may be fixed to the first drive element. The third gear element may be a planetary gear. The third gear element may be rotatably mounted on the carrier radially displaced from a rotational axis of the first drive element on one side of the rotational axis. The third gear element may be rotatable about an axis of rotation that is perpendicular to the rotational axis of the first drive element. This allows an efficient and reliable coupling. More than one third gear element may be provided, e.g., two, three of four third gear elements.

According to an example the first gear element and/or the second gear element are rotatable relative to the first drive element, in particular rotatably mounted on the first drive element, e.g., by means of a respective bearing such as a ball bearing. By this, a very compact design is possible with a little number of parts.

The second gear element may have a (first) toothing in toothed engagement with the third gear element and/or a (second) toothing in toothed engagement with the brake element. By this, the number of parts may be further reduced.

According to a further example, the brake device comprises a support. The brake element may be rotatable relative to the support in the release state and fixedly braked relative to the support in the brake state. The support may be fixedly mounted to, in particular in, the housing. In this manner, a simple but very effective construction of the brake device is possible.

The pusher device may comprise an actuation device operable by a user, such as a user operable switch. The brake device may then be configured to assume the release state in response to an operation of the actuation device. By this, the installation and removal of a syringe can be particularly comfortable and intuitive, because a user may simply grasp the pusher device, thereby actuating the actuation device, and then displace the pusher device manually.

Alternatively, or in addition, the pusher device may comprise a sensor device. The sensor device may be operable by contacting a piston of a syringe received on the receptacle. The sensor device may be a contact sensor or a switch or the like. The brake device may be configured to assume the brake state in response to an operation of the sensor device. By this, for an installation of a syringe, the released pusher device can be simply manually displaced against the piston.

The first drive element may be in engagement with the second drive element. One of the first drive element and the second drive element may comprise a spindle having an outer thread and the other of the first drive element and the second drive element may comprise a spindle nut having an inner thread being in threaded engagement with the outer thread of the spindle. This allows a reliable and robust drive that is simple to manufacture.

Alternatively, the first drive element and the second drive element may form a ball screw. By this, a particularly smoothly running operation is possible. The second drive element may be fixedly connected with the pusher device and displaceable with respect to the first drive element by a rotation of the first drive element relative to the housing. Further, the electric drive may be configured for rotating the first drive element relative to the housing. This enables a reliable operation with a high precision.

The second drive element is, for example, longitudinally displaceable relative to the housing along a guide. The guide may prevent a rotation of the second drive element relative to the housing. Like this, a smooth displacement is possible with a high precision.

The idea underlying the invention shall subsequently be described in more detail by referring to the embodiments shown in the figures. Herein:

Fig. 1 shows an infusion device for administering a fluid to a patient, the infusion device being embodied as a syringe pump;

Fig. 2 shows a schematical drawing of a drive mechanism of the infusion device of Fig. 1;

Fig. 3 shows another drive mechanism for the infusion device of Fig. 1;

Fig. 4 shows a pusher device of the infusion device of Fig. 1 ;

Fig. 5 shows a brake device of the infusion device of Fig. 1 ;

Fig. 6 shows a schematic drawing of a drive mechanism of an infusion device in a second alternative;

Fig. 7 shows a cut view of a drive mechanism following the alternative of

Fig. 6;

Fig. 8 shows a first perspective view of a drive mechanism following the alternative of Fig. 6;

Subsequently, particularly an infusion device shall be described. The embodiments described herein shall not be construed as limiting for the scope of the invention. Fig. 1 illustrates an infusion device 1 in the form of an infusion pump. The infusion device 1 comprises a housing 10 and a receptacle 100 arranged on the housing 10 (e.g., formed by the housing 10) to receive a syringe 2 therein.

A fluid container in the shape of a cylinder barrel 20 of the syringe 2 is connected, via a connector 200, to a delivery line in the form of a tube 3. The tube 3 is or may be connected to a patient for administering a fluid contained in the cylinder barrel 20 to the patient, e.g., via a catheter.

For installing the syringe 2 on the receptacle 100 of the infusion device 1 , the cylinder barrel 20 of the syringe 2 is placed in the receptacle 100 and is mechanically connected to the housing 10 by means of a lock 101 or other fixation device of the infusion device 1. By means of the lock 101, for example constituted by a releasable clamp element, the syringe 2 is secured within the receptacle 100 such that the cylinder barrel 20 of the syringe 2 is held in position on the receptacle 100.

For delivering (medical) fluid contained in the cylinder barrel 20, a piston 11 of the syringe 2 can be pushed into the cylinder barrel 20 in a pushing direction P. For this, the infusion device 1 comprises a pusher device 11 movably arranged on the housing 10 of the infusion device 1 and operatively connected to a drive mechanism D of the infusion device 1 described in more detail below with reference to Fig. 2.

To set up an operation of the infusion device 1 , the syringe 2 is installed and the pusher device 11 is moved towards a piston head 210 of the piston 21 until the pusher device 11 comes into abutment with the piston head 210. For performing an infusion process the pusher device 11 is then moved (electrically, using the drive mechanism D) in the pushing direction P to move the piston 21 into the cylinder barrel 20 for delivering the fluid contained in the cylinder barrel 20 via the tube 3 towards the patient.

The infusion device 1 further comprises a user interface H for inputting commands and, optionally, for outputting information. In the present example, the user interface H is a human-machine interface (HMI). Here, the user interface H comprises a display for outputting information, and at least one input means. In the example of Fig. 1 , the infusion device 1 comprises a plurality of buttons as input means. However, various other means for outputting and/or for inputting information are conceivable, such as a touchscreen, a communicatively connected device, e.g., a keyboard or a mouse, or the like. Fig. 2 shows the drive mechanism D of the infusion device 1.

The drive mechanism D is configured for driving the pusher device 11 back and forth along the pushing direction. The drive mechanism D comprises a first drive element 12, a second drive element 13, an electric drive 14, a brake device 15 and a differential transmission 16.

The first drive element 12 comprises a spindle 120 with an outer thread. The second drive element 13 comprises a spindle nut 130 having an inner thread 131 which is engaged with the outer thread of the spindle 120. The second drive element 13 is fixedly connected with the pusher device 11. The second drive element 13 is displaceable with respect to the first drive element 12 by a motion of the first drive element 12, more specifically, by a rotary motion of the first drive element.

The electric drive 14 comprises an electric motor. The electric drive 14 is configured for driving the first drive element 12 via the transmission 16. The electric drive 14 is mounted on the housing 10.

The brake device 15 comprises a support 150 and a brake element 151. Here, the support

150 is a casing. The support 150 is fixed to the housing 10. A motion of the brake element

151 is braked in a brake state of the brake device 15 and released in a release state of the brake device 15. More specifically, the brake element 151 comprises a gear rotatable relative to the support 150 in the release state and fixed with respect to the support 150 in the brake state.

Via the transmission 16 (and the first drive element 12) the pusher device 11 is operatively connected with the electric drive 14 as well as with the brake element 151.

Here, the electric drive 14 comprises a gear 140. The gear 140 is rotatable by operating the electrical motor. The gear 140 of the electric drive 14 is in toothed engagement with a toothed belt 17. The belt 17 is further in toothed engagement with a first gear element 160 of the transmission 16. In an alternative to a belt 17, and without being out of the scope of the present invention, one or several meshed spur gears could be used instead.

The first gear element 160 is rotatably mounted on the first drive element 12. Alternatively it could be rotatably mounted on the housing 10, for example. The first gear element 160 is rotatable around the axis of rotation of the first drive element 12. The first gear element 160 of the transmission 16 comprises a first toothing 164 and a second toothing 165. The first toothing 164 comprises a first set of teeth along a first circle, and the second toothing 165 comprises a second set of teeth along a second circle separate from the first circle. The second toothing 165 has a larger diameter than the first toothing 164. The first gear element 160 is made in one piece. The first and second toothings 164, 165 of the first gear element 160 are fixed to one another. The first toothing 164 forms a conical gear. The second toothing 165 forms a spur gear.

The second toothing 165 of the first gear element 160 is in toothed engagement with the belt 17. The second toothing 165 of the first gear element 160 has a larger diameter than the gear 140 of the electric drive 14.

The first toothing 164 of the first gear element 160 is in toothed engagement with a toothing of a third gear element 162 of the transmission 16. The third gear element 162 is rotatably mounted on the first drive element 12. Here, the third gear element 162 is rotatable about a rotational axis perpendicular to the rotational axis of the first gear element 160. The third gear element 162 is rotatably mounted on a carrier 163 that is fixedly mounted on the first drive element 10.

The transmission 16 further comprises a second gear element 161. The second gear element 161 is rotatably mounted on the first drive element 12. Alternatively it could be rotatably mounted on the housing 10, for example. The second gear element 161 is rotatable around the axis of rotation of the first drive element 12. The second gear element 161 of the transmission 16 comprises a first toothing 166 and a second toothing 167. The first toothing

166 comprises a first set of teeth along a first circle, and the second toothing 167 comprises a second set of teeth along a second circle separate from the first circle. The second toothing

167 has a larger diameter than the first toothing 166. The second gear element 161 is made in one piece. The first and second toothings 166, 167 of the second gear element 161 are fixed to one another. The first toothing 166 forms a conical gear. The second toothing 167 forms a spur gear.

The first toothing 166 of the second gear element 161 is in toothed engagement with the tooting of the third gear element 162 of the transmission 16. Here, first toothing 166 of the second gear element 161 engages the third gear element 162 on a side of the third gear element 162 opposite the first gear element 160.

The second toothing 167 of the second gear element 161 is in toothed engagement with the gear of the brake element 151. Via the first drive element 12 and the second drive element 13 the pusher device 11 is operatively connected with the transmission 16. The second drive element 13 is fixed to the pusher device 11 and displaceable with respect to the first drive element 12 by a rotation of the first drive element 12.

Thus, when the brake device 15 is in the brake state, the second gear element 161 of the transmission 16 is fixedly held with respect to the housing 10. When activating the electric drive 14, the gear 140 of the electric drive 14 is rotated and moves the belt 17. The belt 17 then rotates the first gear element 160 of the transmission 16 which in turn rotates the third gear element 162 of the transmission 16. Since the second gear element 161 is braked, the third gear element 162 rolls along the second gear element 161. Thereby, the carrier 163 is rotated and, thus, rotates the first drive element 12. The rotation of the first drive element 12 displaces the second drive element 13 along the rotational axis of the first drive element 12. The second drive element 13 is longitudinally displaceable relative to the housing 10 along a guide 18, wherein the guide 18 prevents a rotation of the second drive element 13 relative to the housing 10.

The second drive element 13 is fixed to the pusher device 11, so an activation of the electric drive 14 causes a translational motion of the pusher device 11.

On the other hand, when the brake device 15 is in the release state, the brake element 151 can rotate freely. When the electric drive 14 is deactivated, the pusher device 11 can be manually displaced along the guide 18. Thereby, the brake element 151 is rotated. The electric device 14 stands still due to its self-locking effect. The belt drive has a reduction ratio of 3, and the transmission has a reduction ratio of 2. This results in a reduction ratio of 6.

A controller 19 is provided to control the operation of the electric drive 14 and of the brake device 15.

The screw pitch of the spindle 120 is 2 mm, for example. The detent torque of the electric drive may be 18 mNm.

Fig. 3 shows a schematic drawing of a similar drive mechanism which the infusion device 1 alternatively comprises. Here, several ball bearings 168A-168C are shown. A first ball bearing 168A is mounted on the first drive element 12’ and rotatably supports the first gear element 160 of the transmission 16. A second ball bearing 168B is mounted on a part of the housing 10 and supports the second gear element 161 of the transmission 16. A third ball bearing 168C is mounted on the housing 10 and rotatably supports the first drive element 12’.

Here, the first drive element 12’ and the second drive element 13’ form a ball screw. The first drive element 12’ comprises an outer raceway 122. The second drive element 13’ comprises an inner raceway 132. Between the outer and inner raceways 122, 132, a plurality of balls 133 are arranged.

Turning now to Fig. 4, the pusher device 11 comprises a sensor device 111 operable by contacting the piston head 210 of the piston 21 of the syringe 2 installed in the receptacle 100. The brake device 15 is configured to assume the brake state in response to an operation of the sensor device 111. More specifically, the controller 19 detects an actuation of the sensor device 111 (e.g., a contact sensor) and controls the brake device 15 to assume the brake state in response to this detection.

Further, the pusher device 11 comprises an actuation device 110. The actuation device 110 is operable by the user, and the brake device 15 is configured to assume the release state in response to an operation of the actuation device 110. More specifically, the controller 19 detects an actuation of the actuation device 110 (e.g., a switch) and controls the brake device 15 to assume the release state in response to this detection. The controller 19 may be configured to control the electric drive 14 to operate at a predetermined speed when the brake device 15 is in the release state.

Fig. 5 illustrates further details of the brake device 15 in an exemplary embodiment. Here, the support 150 is a case in which coils 153 are arranged. An activation of the coils 153 attracts magnets 152 mounted on a shaft fixed to the brake element 151. When attracted by the coils 153, the magnets 152 are pulled against the another part of the brake device 15, e.g., the support 150.

In the described solution, the screw-nut system is reversible and becomes easily movable when the brake device 15 is inactive (i.e., free to rotate). When the brake device 15 is not free to rotate, the drive mechanism D becomes irreversible due to the detent torque of the electric motor.

During the manual travel of the pusher device 11 (when the brake device 15 is free to rotate) the electric drive 14 could be rotating as well at a predetermined speed to be able to take over the translation immediately after the brake has been actuated. This allows to avoid a too fast transition from a high speed to a stop. This also allows a smooth transition to the pusher device 11 installation routine that could be executed when the user still holds the pusher device 11. The predetermined motor speed corresponds to the speed adapted to finish engaging the syringe 2 piston head 210 with the pusher device 11 to remove any remaining mechanical play.

The described infusion device 1 allows an excellent displacement resolution with a quick loading time. A very good braking resolution is also provided. Here, the pitch size does not affect a loading stopping point. Little play is possible with a simple design.

Fig. 6 displays an alternative to the schematics shown in Fig. 2. Rather than using the classic differential mechanism embodiment of the Fig. 2 (similar to well-known spherical differential designs with the third gear element 162 axis being perpendicular to the first and second gear elements axis 160, 161), Fig. 6 shows the use of an epicyclic gear train 169 (all axes of gears being parallel). In this example, the electric drive 14 is connected to the sun gear 170 thanks to the belt 17. The sun gear 170 is rotating with a reduction ratio relative to the electric drive depending on the dimensions of the sun gear 170 and the electric drive gear 140. As an alternative to the use of a belt, the use of spur gears can be imagined.

The sun gear 170 meshes with the planet gears 171 , which are typically three different planet gears distributed 120° apart the ones from the others (numbers may vary), these planet gears 171 being in mesh relation with the brake element 151 via an outer ring 172. The planet gears 171 are also in connection with a carrier 173 integral with the first drive element 12.

In a drive mode, the electric drive 14 being activated, the carrier 173 is driven following a gear ratio depending on the dimensions of the different gears forming the epicyclic drive, following the well-known rules of such gear train. Eventually, the second drive element 13 is then moved forward or backward depending on the electric drive 14 rotation direction.

In a stop mode, the electric drive being stopped and the brake device 15 being deactivated, the second drive element 13 can be freely moved backward or forward by an external user via the pusher device 11. Actually, in this situation, the sun gear 170 is blocked thanks to the detent torque of the electric drive 14 while the outer ring is free to rotate (since the brake device 15 is deactivated), allowing the carrier 173 and planet gears 171 to rotate freely. In a brake mode, the electric drive 14 being stopped and the brake element 15 being activated, both the sun gear 170 and the outer ring 172 are blocked and cannot rotate. In consequences, the carrier 173 and the planet gears 171 are not allowed to rotate since they are blocked in their respective rotations.

Fig. 7 and Fig. 8 show, respectively in a cut view and a plain perspective view, a realistic embodiment of the present invention following the schematic of Fig. 6, where some of the different elements constituting the drive and the brake elements are visible.

The idea of the invention is not limited to the embodiments described above but may be implemented in a different fashion.

List of Reference Numerals

1 Infusion device

10 Housing

100 Receptacle

101 Lock

11 Pusher device

110 Actuation device

111 Sensor device

12, 12’ First drive element

120 Spindle

121 Outer thread

122 Outer raceway

13, 13’ Second drive element

130 Spindle nut

131 Inner thread

132 Inner raceway

133 Ball

14 Electric drive

140 Gear

15 Brake device

150 Support

151 Brake element

152 Magnet

153 Coil

16 Transmission

160 First gear element

161 second gear element

162 third gear element

163, 173 Carrier

164, 165 First, second toothing of first gear element

166, 167 First, second toothing of second gear element

168A-168C Bearing

169 Planetary gear train

170 sun gear

171 planet gears

172 outer gear 17 Belt

18 Guide

19 Controller

2 Syringe 20 Cylinder barrel

200 Connector

21 Piston

210 Piston head

3 Tube D Drive mechanism

H Interface

P Pushing direction

Claims

1. Infusion device (1) for administering a medical fluid to a patient, comprising: a housing (10) having a receptacle (100) for receiving a syringe (2), a pusher device (11) which is movable for acting onto a piston (21) of a syringe (2) received on the receptacle (100), and a drive mechanism (D) for driving the pusher device (11) and comprising: o an electric drive (14), and o a brake device (15) having a brake element (151), wherein a motion of the brake element (151) is braked in a brake state of the brake device (15) and released in a release state of the brake device (15), characterized in that the drive mechanism (D) further comprises a differential transmission (16) via which the pusher device (11) is operatively connected with the electric drive (14) and the brake element (151).

2. Infusion device (1) according to claim 1 , characterized in that drive mechanism (D) further comprises a first drive element (12, 12’) and a second drive element (13, 13’) via which the pusher device (11) is operatively connected with the differential transmission (16), the second drive element (13, 13’) being connected with the pusher device (11) and displaceable with respect to the first drive element (12, 12’) by a motion of the first drive element (12, 12’), the electric drive (14) being configured for driving the first drive element (12, 12’) via the transmission (16).

3. Infusion device (1) according to claim 1 or 2, characterized in that the transmission (16) comprises a first gear element (160), a second gear element (161) and a third gear element (162), the third gear element (162) being in toothed engagement with the first gear element (160) and with the second gear element (161).

4. Infusion device (1) according to claim 3, characterized in that the first gear element (160) is configured to be driven by the electric drive (14) and to drive the third gear (162) when being driven by the electric drive (14).

5. Infusion device (1) according to claim 3 or 4, characterized in that a belt (17) operatively connects the electric drive (14) with the first gear element (160).

6. Infusion device (1) according to one of claims 3 to 5, characterized in that the third gear element (162) is rotatably mounted on a carrier (163), the carrier (163) being fixed to the first drive element (12, 12’).

7. Infusion device (1) according to one of claims 3 to 6, characterized in that the first gear element (160) and the second gear element (161) are rotatable relative to the first drive element (12, 12’), in particular rotatably mounted on the first drive element (12, 12’).

8. Infusion device (1) according to one of claims 3 to 7, characterized in that the second gear element (161) has a first toothing (166) in toothed engagement with the third gear element (162) and a second toothing (167) in toothed engagement with the brake element (151).

9. Infusion device (1) according to one of the preceding claims, characterized in that the brake device (15) comprises a support (150), wherein the brake element (151) is rotatable relative to the support (150) in the release state and fixedly braked relative to the support (150) in the brake state, wherein the support (150) is fixedly mounted on the housing (10).

10. Infusion device (1) according to one of the preceding claims, characterized in that the pusher device (11) comprises an actuation device (110) operable by a user, wherein the brake device (15) is configured to assume the release state in response to an operation of the actuation device (110).

11. Infusion device (1) according to one of the preceding claims, characterized in that the pusher device (11) comprises a sensor device (111) operable by contacting a piston (21) of a syringe (2) received on the receptacle (100), wherein the brake device (15) is configured to assume the brake state in response to an operation of the sensor device (111).

12. Infusion device (1) according to one of the preceding claims, characterized in that the first drive element (12) is in engagement with the second drive element (13), wherein one of the first drive element (12) and the second drive element (13) comprises a spindle (120) having an outer thread (121) and the other of the first drive element (12) and the second drive element (13) comprises a spindle nut (130) having an inner thread (131) being in threaded engagement with the outer thread (121) of the spindle (120).

13. Infusion device (1) according to one of the preceding claims, characterized in that the first drive element (12’) and the second drive element (13’) form a ball screw.

14. Infusion device (1) according to one of the preceding claims, characterized in that the second drive element (13, 13’) is fixedly connected with the pusher device (11) and displaceable with respect to the first drive element (12, 12’) by a rotation of the first drive element (12, 12’) relative to the housing (10), the electric drive (14) being configured for rotating the first drive element (12, 12’) relative to the housing (10).

15. Infusion device (1) according to one of the preceding claims, characterized in that the second drive element (13, 13’) is longitudinally displaceable relative to the housing (10) along a guide (18), the guide (18) preventing a rotation of the second drive element (13, 13’) relative to the housing (10).