[go: up one dir, main page]

WO2025061420A1 - Composition de nettoyage antimicrobienne - Google Patents

Composition de nettoyage antimicrobienne Download PDF

Info

Publication number
WO2025061420A1
WO2025061420A1 PCT/EP2024/073846 EP2024073846W WO2025061420A1 WO 2025061420 A1 WO2025061420 A1 WO 2025061420A1 EP 2024073846 W EP2024073846 W EP 2024073846W WO 2025061420 A1 WO2025061420 A1 WO 2025061420A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
soap
salt
glda
mgda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/073846
Other languages
English (en)
Inventor
Sameer Keshav Barne
Karthika BEENA
Akshatha NARASIMHAMURTHY
Maya Treesa Saji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever Global IP Ltd
Unilever IP Holdings BV
Conopco Inc
Original Assignee
Unilever Global IP Ltd
Unilever IP Holdings BV
Conopco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Global IP Ltd, Unilever IP Holdings BV, Conopco Inc filed Critical Unilever Global IP Ltd
Publication of WO2025061420A1 publication Critical patent/WO2025061420A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0047—Detergents in the form of bars or tablets

Definitions

  • the present invention relates to a personal cleansing composition. Particularly, it relates to a skin cleansing composition that provides improved antimicrobial benefit.
  • a handwash or bodywash composition e.g. a handwash or bodywash compositions
  • Such skin cleansing compositions are available in the form of a solid e.g. a bar such as soap bar; and in the form of a liquid e.g. a liquid handwash or bodywash composition or in the form of powder, which can be diluted with water before use.
  • antimicrobial benefit delivered by such skin cleansing compositions is delivered by one or more antimicrobial actives that may be included in such compositions.
  • skin cleansing composition comprising an antibacterial active e.g. triclosan, is known in the art.
  • a soap bar composition is meant a cleansing composition comprising soap which is in the form of a shaped solid.
  • the soap bar of the invention is especially useful for personal cleansing.
  • the cosmetically acceptable vehicle comprises water, soap other than salt of lauric acid, structuring agent, electrolyte, polymer or combinations thereof.
  • the soap bar of the present invention is for personal washing application it comprises 15 to 75% soap (other than the salt of lauric acid), preferably 20 to 75%, more preferably 25 to 70 and most preferably 50 to 70% by weight of the soap bar.
  • the personal washing composition comprises at least 15%, preferably at least 20%, more preferably at least 25% soap other than the salt of lauric acid by weight of the composition.
  • the personal washing composition also futher preferably comprises at most 50%, more preferably at most 60%, further more preferably at most 75% soap other than salt of lauric acid by weight of the composition.
  • the composition preferably comprises a polyhydric alcohol (also called polyol) or mixture of polyols.
  • Polyol is a term used herein to designate a compound having multiple hydroxyl groups (at least two, preferably at least three) which is highly water soluble.
  • Many types of polyols are available including: relatively low molecular weight short chain polyhydroxy compounds such as glycerol and propylene glycol; sugars such as sorbitol, mannitol, sucrose and glucose; modified carbohydrates such as hydrolyzed starch, dextrin and maltodextrin, and polymeric synthetic polyols such as polyalkylene glycols, for example polyoxyethylene glycol (PEG) and polyoxypropylene glycol (PPG).
  • PEG polyoxyethylene glycol
  • PPG polyoxypropylene glycol
  • the soap bar composition generally comprises electrolyte and water. Electrolytes as per this invention include compounds that substantially dissociate into ions in water. Electrolytes as per this invention are not an ionic surfactant. Suitable electrolytes for inclusion in the soap making process are alkali metal salts. Preferred alkali metal salts include sodium sulfate, sodium chloride, sodium acetate, sodium citrate, potassium chloride, potassium sulfate, sodium carbonate and other mono or di or tri salts of alkaline earth metals, more preferred electrolytes are sodium chloride, sodium sulfate, sodium citrate, potassium chloride and especially preferred electrolyte is sodium chloride, sodium sulphate, sodium citrate or a combination thereof.
  • the total level of the adjuvant materials used in the bar composition generally is in an amount not higher than 50%, preferably 1 to 50%, more preferably 3 to 45% by wt. of the soap bar composition.
  • the insoluble particles should not be perceived as scratchy or granular and thus should have a particle size less than 300 microns, more preferably less than 100 microns and most preferably less than 50 microns.
  • Calcium carbonate or chalk exists in three crystal forms: calcite, aragonite and vaterite.
  • the natural morphology of calcite is rhombohedral or cuboidal, acicular or dendritic for aragonite and spheroidal for vaterite.
  • insoluble inorganic particulate materials examples include aluminates, silicates, phosphates, insoluble sulfates, borates and clays (e.g., kaolin, china clay) and their combinations.
  • Organic particulate materials include: insoluble polysaccharides such as highly crosslinked or insolubilized starch (e.g., by reaction with a hydrophobe such as octyl succinate) and cellulose; synthetic polymers such as various polymer lattices and suspension polymers; insoluble soaps and mixtures thereof.
  • insoluble polysaccharides such as highly crosslinked or insolubilized starch (e.g., by reaction with a hydrophobe such as octyl succinate) and cellulose
  • synthetic polymers such as various polymer lattices and suspension polymers
  • insoluble soaps and mixtures thereof include: insoluble polysaccharides such as highly crosslinked or insolubilized starch (e.g., by reaction with a hydrophobe such as octyl succinate) and cellulose; synthetic polymers such as various polymer lattices and suspension polymers; insoluble soaps and mixtures thereof.
  • Bar compositions preferably comprise 0.1 to 25% by wt. of bar composition, preferably 5 to 15 by wt. of these mineral or organic particles. It is preferred that the compositions of the invention comprise polymers. Polymers of the acrylate class are especially preferred. Preferred bars include 0.05 to 5% acrylates. More preferred bars include 0.01 to 3% acrylates. Examples of acrylate polymers include polymers and copolymers of acrylic acid crosslinked with polyallylsucrose as described in US Patent 2,798,053 which is herein incorporated by reference.
  • polyacrylates examples include polyacrylates, acrylate copolymers or alkali swellable emulsion acrylate copolymers, hydrophobically modified alkali swellable copolymers, and crosslinked homopolymers of acrylic acid.
  • examples of such commercially available polymers are: ACULYN®, CARBOPOL®, and CARBOPOL® Ultrez grade series.
  • An opacifier may be optionally present in the personal care composition.
  • the cleansing bar is generally opaque.
  • examples of opacifiers include titanium dioxide, zinc oxide and the like.
  • a particularly preferred opacifier that can be employed when an opaque soap composition is desired is ethylene glycol mono- or di-stearate, for example in the form of a 20% solution in sodium lauryl ether sulphate.
  • An alternative opacifying agent is zinc stearate.
  • the product can take the form of a water-clear, i.e. transparent soap, in which case it will not contain an opacifier.
  • the pH of preferred soaps bars of the invention is from 8 to 11 , more preferably 9 to 11.
  • a preferred bar may additionally include up to 30 wt% benefit agents.
  • Preferred benefit agents include moisturizers, emollients, sunscreens and anti-ageing compounds.
  • the agents may be added at an appropriate step during the process of making the bars.
  • Some benefit agents may be introduced as macro domains.
  • ingredients like anti-oxidants, perfumes, polymers, colourants, deodorants, dyes, enzymes, foam boosters, lathering agents, pearlescers, skin conditioners, stabilizers or superfatting agents, may be added in suitable amounts in the process of the invention.
  • the ingredients are added after the saponification step.
  • Another aspect of the present invention relates to a method of killing both gram negative and gram positive bacteria comprising the step of washing a surface with a composition of the first aspect preferably diluted with water for at least 15 seconds to 2 minutes followed by the step of rinsing the surface with water or wiping the surface to be substantially free of said composition.
  • the method is preferably non-therapeutic.
  • Examples A-E,1 Effect of the composition on the log reduction of E.coli.
  • Escherichia. coli ATCC 10536 was used in the study to represent gram negative bacteria and Staphylococcus aureus ATCC 6538 was used to represent gram positive bacteria.
  • the bacteria were grown overnight on Trypticase soya agar (TSA) plate.
  • TSA Trypticase soya agar
  • the bacterial cell density was then adjusted at 620 nm to a pre-calibrated optical density to get the final count of 10 9 cfu/ml in saline (0.86% NaCI) by using a spectrophotometer.
  • ASTM International E2783-16 is a standard test method for assessment of antimicrobial activity for water miscible compounds using a Time -Kill procedure.
  • the antibacterial activity of the comparative composition was neutralized immediately, by addition of 1 mL of the above mixture to 9 mL of an appropriate neutralizing broth which is validated for the test system.
  • the neutralized samples were then serially diluted upto 5 dilution in neutralizer broth and plated on TSA (40gpl - Difco) in duplicates.
  • control used was a mixture prepared by addition of 0.1 mL of bacterial culture to 9.9 mL of saline; the mixture was then serially diluted and plated on TSA. After solidification of the TSA plates, the plates were incubated at 37°C for 48 hours. The colonies on the plates were counted. The log reduction was calculated by comparing with the control.
  • composition as per the invention (Example -1) provides for vastly improved log reduction as compared to the individual ingredients or subset combinations.
  • Example F-G,2 Effect of the composition at different concentrations on the log reduction o E.coli.
  • Table - 6 The data in table -6 above indicates that composition as per the invention (Example -5) provides for vastly improved log reduction of E. coli bacteria as compared to the base soap noodle and a subset combination.
  • Examples O-R, 6 Example O-R and 6: Effect of using a different activity enhancer on the log reduction of E.coli.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Detergent Compositions (AREA)

Abstract

La présente invention concerne une composition d'hygiène personnelle. En particulier, l'invention concerne une composition de nettoyage de la peau qui fournit un effet bénéfique antimicrobien amélioré. L'effet bénéfique antimicrobien est obtenu par l'intermédiaire d'une combinaison de laurate de sodium avec deux amplificateurs d'activité, dont au moins un est choisi parmi une liste d'agents chélateurs connus.
PCT/EP2024/073846 2023-09-20 2024-08-26 Composition de nettoyage antimicrobienne Pending WO2025061420A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23198518.5 2023-09-20
EP23198518 2023-09-20

Publications (1)

Publication Number Publication Date
WO2025061420A1 true WO2025061420A1 (fr) 2025-03-27

Family

ID=88098546

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/073846 Pending WO2025061420A1 (fr) 2023-09-20 2024-08-26 Composition de nettoyage antimicrobienne

Country Status (1)

Country Link
WO (1) WO2025061420A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2798053A (en) 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US20160362646A1 (en) * 2014-01-29 2016-12-15 Conopco, Inc., D/B/A Unilever Cleansing composition containing oligodynamic metal and efficacy enhancing agent
EP3201306B1 (fr) * 2014-09-29 2019-11-06 Unilever NV Compensation de nettoyage antimicrobien
US20220135910A1 (en) * 2019-03-01 2022-05-05 Conopco, Inc., D/B/A Unilever Bar compositions comprising c10 soap while minimizing ratio of unsaturated c18 soap to caprate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2798053A (en) 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US20160362646A1 (en) * 2014-01-29 2016-12-15 Conopco, Inc., D/B/A Unilever Cleansing composition containing oligodynamic metal and efficacy enhancing agent
EP3201306B1 (fr) * 2014-09-29 2019-11-06 Unilever NV Compensation de nettoyage antimicrobien
US20220135910A1 (en) * 2019-03-01 2022-05-05 Conopco, Inc., D/B/A Unilever Bar compositions comprising c10 soap while minimizing ratio of unsaturated c18 soap to caprate

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD [online] MINTEL; 12 December 2015 (2015-12-12), ANONYMOUS: "Cleansing Soap", XP055585150, retrieved from https://www.gnpd.com/sinatra/recordpage/3673929/ Database accession no. 3673929 *
DATABASE GNPD [online] MINTEL; 22 May 2013 (2013-05-22), ANONYMOUS: "Shower Cream for Men", XP093136564, retrieved from https://www.gnpd.com/sinatra/recordpage/2076197/ Database accession no. 2076197 *
DATABASE GNPD [online] MINTEL; 23 March 2004 (2004-03-23), ANONYMOUS: "Cleansing Bar", XP093130443, retrieved from https://www.gnpd.com/sinatra/recordpage/261414/ Database accession no. 261414 *

Similar Documents

Publication Publication Date Title
DE69024323T2 (de) Antimikrobielles Verfahren und Formulierung unter Verwendung von Endoglycosidase vom Typ II und antimikrobielles Mittel
DE69029361T2 (de) Verfahren und Formulierung unter Verwendung von Endoglycosidase vom Typ II
DE69024324T2 (de) Verfahren unter Verwendung von Endoglycosidase vom Typ II
AT391623B (de) Desodorierendes koerperreinigungsmittel
US6559110B1 (en) Syndet bar soap having an acidifying agent
EA024551B1 (ru) Индивидуальная композиция для очищения
EP2892991B1 (fr) Composition de savon
EA038526B1 (ru) Противомикробная композиция, содержащая олигодинамический металл
JP2023075279A (ja) カプリル酸を含む非石鹸液体洗浄剤組成物
WO2017067852A1 (fr) Composition antimicrobienne
EP2787955B1 (fr) Composition antimicrobienne
EP3880781A1 (fr) Pain de savon extrudé à efficacité antimicrobienne améliorée
WO2025061420A1 (fr) Composition de nettoyage antimicrobienne
EA022660B1 (ru) Способ антибактериальной обработки кожи
TW202506980A (zh) 清潔組成物
WO2019174928A1 (fr) Composition particulaire antimicrobienne et composition de soins personnels comprenant cette composition
JP2000273489A (ja) 化粧料用組成物および洗浄保存液
CN116396811A (zh) 一种具有高生物酶活性抑菌的内衣洗衣液及其制备方法
TW201408289A (zh) 椰油醇聚醚硫酸酯鋅作爲抗痤瘡丙酸桿菌之抗細菌劑的用途
CN111743793A (zh) 一种洗手液及其制备方法
KR102765272B1 (ko) 항균활성을 갖는 무방부제 액체 세정제 조성물
CA3224816A1 (fr) Compositions de soins personnels comprenant des agents benefiques naturels tels que de l'huile de lin et leurs methodes d'utilisation
JPH03172397A (ja) 洗浄剤組成物
CA3047808A1 (fr) Composition antimicrobienne
WO2013060558A1 (fr) Efficacité antimicrobienne du (s)-(-)-alpha-terpinéol

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24761629

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)