WO2025059437A1 - Method and apparatus for cooling a body of a donor - Google Patents

Abstract

Apparatus and methods for cooling a body of a donor are provided. The cooling apparatus (100) includes a vessel (104) and a pump (112) configured to circulate a fluid through the vessel while a body of a donor is in the vessel. The vessel may be a basin or a bag. The fluid (120) may comprise a first fluid (134) and/or a refrigerant (144). The cooling apparatus may further comprise a controller (130), a fluid temperature controller (112), a fluid composition controller (126) and/or a chest compression device (114).

Description

METHOD AND APPARATUS FOR COOLING A BODY OF A DONOR

RELATED APPLICATION

[0001] This application claims priority to U.S. Provisional Patent Application No. 63/538,652, filed on September 15, 2023, entitled “WHOLE BODY HYPOTHERMIC ORGAN PRESERVATION," which is incorporated herein by reference in its entirety.

TECHNICAL FIELD

[0002] The present disclosure relates to organ preservation.

BACKGROUND

[0003] Organ transplantation can be a life-saving medical procedure in which a failing and/or damaged organ is replaced with an organ from a donor. Transplanted organs include the lungs, heart, liver, kidneys, pancreas, etc. Transplants can come from living donors or deceased individuals.

SUMMARY

[0004] In accordance with the present disclosure, one or more apparatuses and/or methods are provided. In an example, a cooling apparatus is provided. The cooling apparatus may include a vessel and/or a pump configured to circulate a fluid through the vessel while a body of a donor is in the vessel.

[0005] In an example, a method is provided. The method may include circulating, using a pump, a fluid through a vessel while a body of a donor is in the vessel. The method may include performing, using a chest compression device, chest compressions on the body while the body is in the vessel.

[0006] In an example, a cooling apparatus is provided. The cooling apparatus may include a vessel and/or a pump connected to the vessel via a first set of conduits and a second set of conduits, wherein the pump is configured to pump a fluid into the vessel via the first set of conduits while a body of a donor is in the vessel. The fluid may exit the vessel through the second set of conduits.

DESCRIPTION OF THE DRAWINGS

[0007] While the techniques presented herein may be embodied in alternative forms, the particular embodiments illustrated in the drawings are only a few examples that are supplemental of the description provided herein. These embodiments are not to be interpreted in a limiting manner, such as limiting the claims appended hereto.

[0008] Fig. 1 is an illustration of a cooling apparatus, in accordance with some embodiments.

[0009] Fig. 2A is an illustration of a side view of a cooling apparatus comprising a support structure, in accordance with some embodiments.

[0010] Fig. 2B is an illustration of a perspective view of a support structure, in accordance with some embodiments.

[0011] Fig. 3 is an illustration of a cooling apparatus, in accordance with some embodiments.

[0012] Fig. 4 is an illustration of a cooling apparatus, in accordance with some embodiments.

[0013] Fig. 5 is a flow chart illustrating an example method, in accordance with some embodiments.

[0014] Fig. 6 is an illustration of a scenario featuring an example non- transitory machine readable medium in accordance with one or more of the provisions set forth herein.

DETAILED DESCRIPTION

[0015] Subject matter will now be described more fully hereinafter with reference to the accompanying drawings, which form a part hereof, and which show, by way of illustration, specific example embodiments. This description is not intended as an extensive or detailed discussion of known concepts. Details that are known generally to those of ordinary skill in the relevant art may have been omitted, or may be handled in summary fashion.

[0016] The following subject matter may be embodied in a variety of different forms, such as methods, devices, components, and/or systems. Accordingly, this subject matter is not intended to be construed as limited to any example embodiments set forth herein. Rather, example embodiments are provided merely to be illustrative. Such embodiments may, for example, take the form of hardware, software, firmware, medicine, clothing design, or any combination thereof.

[0017] Many organs have traditionally been deemed unfit for transplantation. The shortage of organs available to those actively awaiting transplantation can be avoided by using organs from donation after cardiocirculatory death (“DCD”). Protecting organ function (e.g., lung function) from negative uncontrolled donation parameters (e.g., warm ischemia injury) may expand the donor pool (e.g., the lung donor pool and/or donor pool of other organs). According to some embodiments, a cooling apparatus is provided for organ preservation (e.g., whole body hypothermic organ preservation). The cooling apparatus may be used for cooling and/or preserving one or more organs (e.g., at least one of the lungs, the heart, the liver, a kidney, etc.) of a body for longer. Using the cooling apparatus may extend a viable window associated with transplantation of the one or more organs. The cooling apparatus may circulate a fluid (e.g., a fluid comprising a refrigerant) through a vessel in which the body is positioned. The fluid may absorb heat from the body. The cooling apparatus may use a chest compression device to perform chest compressions on the body, which may provide for improved cooling and/or preservation of the body, such as due, at least in part, to (i) increased blood circulation and/or movement through one or more portions of the body (e.g., the lungs and/or heart) and/or (ii) increased blood perfusion associated with the body. In some examples, using the cooling apparatus in accordance with the present disclosure may extend a viable window associated with transplantation of uncontrolled DCD (uDCD) lungs (and/or enables the uDCD lungs to be transplanted), which may significantly expand the lung donor pool. Other types of organ donations other than uDCD (e.g., donation from a person who dies due to a cardiac arrest after unsuccessful resuscitation) are within the scope of the present disclosure.

[0018] Fig. 1 illustrates a cooling apparatus 100, in accordance with some examples. The cooling apparatus 100 may be used to cool a body 102 of a donor for (i) preservation of one or more organs (e.g., the lungs of the body, the heart of the body, the liver, a kidney, etc.) and/or (ii) mitigation (e.g., prevention and/or reduction) of injury to the one or more organs. The cooling apparatus 100 may comprise a vessel 104, a pump 1 12, a controller 130, a fluid temperature controller 1 12, a fluid composition controller 126 and/or a chest compression device 114.

[0019] In some examples, the vessel 104 may comprise a basin (e.g., a tank, a tub, etc.) comprising one or more walls defining a chamber 103 and/or an opening 105 into the chamber 103. In some examples, the body 102 is moved through the opening 105 to a target position relative to the vessel 104. Fig. 1 depicts the body 102 in the target position in accordance with some examples. In some examples, when the body 102 is in the target position, an entirety of the body 102 is in the chamber 103 defined by the vessel 104. Alternatively and/or additionally, when the body 102 is in the target position, a portion of the body 102 (e.g., the head of the body 102) may be outside the chamber 103 (e.g., the head of the body 102 may be over and/or outside the chamber 103).

[0020] In some examples, the pump 112 circulates a fluid 120 through the vessel 104 while the body 102 is in the vessel 104 (e.g., while the body 102 is in the target position relative to the vessel 104). In some examples, the cooling apparatus 100 comprises a fluid circuit established by (i) a first set of conduits 180 (e.g., a first set of one or more conduits), (ii) a second set of conduits 182 (e.g., a second set of one or more conduits), (iii) a third set of conduits 184 (e.g., a third set of one or more conduits), and/or (iv) a fourth set of conduits 186 (e.g., a fourth set of one or more conduits).

[0021] In some examples, the fluid 120 is controlled and/or introduced to the fluid circuit using the fluid composition controller 126. The fluid composition controller 126 may be connected to a fluid source 136 via a fifth set of conduits 132 (e.g., a fifth set of one or more conduits). The fluid source 136 may supply a first fluid 134 to the fluid composition controller 126 and/or the fluid circuit via the fifth set of conduits 132. The fluid composition controller 126 may be connected to a refrigerant source 146 via a sixth set of conduits 142 (e.g., a sixth set of one or more conduits). The refrigerant source 146 may supply a refrigerant 144 to the fluid composition controller 126 and/or the fluid circuit via the sixth set of conduits 142.

[0022] In some examples, the fluid 120 comprises the first fluid 134 and/or the refrigerant 144. The fluid composition controller 126 may control a fluid composition associated with the fluid 120 circulating through the vessel 104 and/or the fluid circuit by (i) controlling (e.g., increasing, decreasing, maintaining, etc.) an amount of the first fluid 134 introduced into the fluid circuit and/or (ii) controlling (e.g., increasing, decreasing, maintaining, etc.) an amount of the refrigerant 144 introduced into the fluid circuit. In some examples, the first fluid 134 (supplied by the fluid source 136, for example) may comprise at least one of water, glycol, liquid, gas, one or more antifreeze agents, etc. In some examples, the refrigerant 144 (supplied by the refrigerant source 146, for example) may comprise Sodium Chloride (NaCI), ethanol, Calcium chloride (CaCI₂), a refrigerant solution (e.g., at least one of NaCI solution, ethanol solution, CaCI₂ solution, etc.), and/or other suitable refrigerant. In some examples, the fluid composition controller 126 introduces the fluid (e.g., the first fluid 134 and/or the refrigerant 144) into the fourth set of conduits 186.

[0023] In some examples, the fourth set of conduits 186 is configured to conduct the fluid 120 to a set of outlets (e.g., a set of one or more outlets). The set of outlets may be configured to emit the fluid 120 into the chamber 105 defined by the vessel 104. In some examples, the set of outlets may be configured to emit the fluid 120 onto the body 102 and/or one or more walls of the vessel 104. In some examples, the set of outlets comprises a first outlet 192 (e.g., a port, an aperture, a dispenser, a spout, etc.) and/or a second outlet 194 (e.g., a port, an aperture, a dispenser, a spout, etc.). In some examples, the fluid 120 may comprise frozen pieces 145 (e.g., ice). [0024] In some examples, the fluid 120 may flow through the chamber 103 defined by the vessel 104 in a direction 109. In some examples, while the fluid 120 is in the chamber 103 (and/or while the fluid 120 is flowing in the direction 109), the fluid 120 is in contact with the body 102. In some examples, the body 102 may be at least partially submerged in the fluid 120 (within the chamber 103, for example), such while the fluid 120 is being circulated through the vessel 104 using the pump 112. In some examples, the fluid 120 absorbs heat from the body 102 to cool and/or preserve the body 102. In some examples, the fluid 120 cools the body 102 via saturation of the fluid 120 with the body 102. Embodiments are contemplated in which there is a layer, such as a bag and/or sheet, between the body 102 and the fluid 120. In some examples, the fluid 120 absorbs heat from the body 102 through the layer. In an example, the layer may correspond to a layer of a bag wrapped around (and/or at least partially surrounding) the body 102. In some examples, the bag (not shown) may be at least partially sealed to mitigate (e.g., prevent and/or reduce) contact of the fluid 120 with the body 120. In some examples, the bag comprises one or more materials (e.g., one or more plastics and/or other materials) that allow transfer of heat from the body 120 through the bag to the fluid 120.

[0025] In some examples, the fluid 120 may exit the vessel 104 through the first set of conduits 180. For example, the fluid 120 may flow through an outlet 121 defined by the vessel 104 (e.g., the outlet 121 may be defined by a floor of the vessel 104) into the first set of conduits 180. In some examples, the first set of conduits 180 may conduct the fluid 120 from the vessel 104 to the pump 1 12. In some examples, the second set of conduits 182 may conduct the fluid 120 from the pump 112 to the fluid temperature controller 116. In some examples, the pump 112 may be configured to control a flow rate associated with the fluid 120. The flow rate associated with the fluid 120 may correspond to a speed with which the fluid 120 circulates through the fluid circuit established by the cooling apparatus 100. In some examples, the pump 112 may be configured to control the flow rate associated with the fluid 120 based upon a target flow rate. The target flow rate may correspond to a target flow rate value and/or a target flow rate range. In some examples, the pump 112 may control the fluid flow rate such that the fluid flow rate matches the target flow rate. In some examples, the fluid flow rate may be considered to match the target flow rate when the fluid flow rate is about equal to (and/or within a threshold difference of) the target flow rate value. Alternatively and/or additionally, the fluid flow rate may be considered to match the target flow rate when the fluid flow rate is within the target flow rate range.

[0026] In some examples, the fluid temperature controller 116 may be configured to control a fluid temperature associated with the fluid 120. The fluid temperature controller 1 16 may regulate the fluid temperature based upon a target fluid temperature. The target fluid temperature may correspond to a target fluid temperature value and/or a target fluid temperature range. In some examples, the target fluid temperature value may be (i) between about - 5 degrees Celsius to about -40 degrees Celsius, (ii) between about -10 degrees Celsius to about -30 degrees Celsius, (iii) between about -17 degrees Celsius to about -25 degrees Celsius), and/or (iv) about -21 degrees Celsius. In some examples, the target fluid temperature range may range from a minimum fluid temperature value to a maximum fluid temperature value. The minimum fluid temperature value may be (i) between about -22 degrees Celsius to about -40 degrees Celsius, (ii) between about -22 degrees Celsius to about -25 degrees Celsius, and/or (iii) about -25 degrees Celsius. The maximum fluid temperature value may be (I) between about -5 degrees Celsius to about -20 degrees Celsius, (ii) between about -5 degrees Celsius to about -17 degrees Celsius, and/or (iii) about -17 degrees Celsius.

[0027] The fluid temperature controller 116 may cool the fluid 120 using one or more cooling components such as at least one of a compressor, a condenser, an evaporator, an expansion valve, capillary tube, a heat exchanger, etc. In some examples, the fluid temperature controller 116 may control the fluid temperature such that the fluid temperature matches the target fluid temperature. In some examples, the fluid temperature may be considered to match the target fluid temperature when the fluid temperature is about equal to (and/or within a threshold difference of) the target fluid temperature value. Alternatively and/or additionally, the fluid temperature may be considered to match the target fluid temperature when the fluid temperature is within the target fluid temperature range. The third set of conduits 184 may conduct the fluid 120 from the fluid temperature controller 116 to the fluid composition controller 126 and/or the fourth set of conduits 186.

[0028] In some examples, the chest compression device 114 may be configured to perform chest compressions on the body (e.g., on the chest of the body). In some examples, the chest compression device 114 comprises an automated cardiopulmonary resuscitation (CPR) device. The chest compression device 1 14 may comprise a LUCAS® Chest Compression System and/or other type of chest compression device. In some examples, a chest compression rate with which the chest compression device 114 performs chest compressions on the body 102 may be based upon a target chest compression rate. The target chest compression rate may correspond to a target chest compression rate value and/or a target chest compression rate range. In some examples, the chest compression rate may correspond to a frequency of chest compressions performed by the chest compression device 114 per unit of time. In some examples, the chest compression device 114 may perform chest compressions on the body 102 based upon the target chest compression rate such that the chest compression rate matches the target chest compression rate. In some examples, the chest compression rate may be considered to match the target chest compression rate when the chest compression rate is about equal to (and/or within a threshold difference of) the target chest compression rate value. Alternatively and/or additionally, the chest compression rate may be considered to match the target chest compression rate when the chest compression rate is within the target chest compression rate range.

[0029] In some examples, a chest compression force with which the chest compression device 1 14 performs chest compressions on the body 102 may be based upon a target chest compression force. The target chest compression force may correspond to a target chest compression force value and/or a target chest compression force range. In some examples, the chest compression force may correspond to (i) a magnitude of force of chest compressions performed by the chest compression device 1 14 and/or (ii) a systolic arterial pressure associated with the chest compressions performed by the chest compression device 114 on the body 102 (e.g., a systolic arterial pressure of the body 102 as a result of chest compressions performed by the chest compression device 114). In some examples, the chest compression device 114 may perform chest compressions on the body 102 based upon the target chest compression force such that the chest compression force matches the target chest compression force. In some examples, the chest compression force may be considered to match the target chest compression force when the chest compression force is about equal to (and/or within a threshold difference of) the target chest compression force value.

Alternatively and/or additionally, the chest compression force may be considered to match the target chest compression force when the chest compression force is within the target chest compression force range.

[0030] In some examples, the target chest compression force value (e.g., target systolic arterial pressure value of the body 102) may be (i) between about 6 mmHg to about 86 mmHg, (ii) between about 16 mmHg to about 76 mmHg, (Hi) between about 24 mmHg to about 68 mmHg, and/or (iv) about 46 mmHg. In some examples, the target chest compression force range (e.g., target systolic arterial pressure range of the body 102) may range from a minimum chest compression force value to a maximum chest compression force value. The minimum chest compression force value may be (I) between about 6 mmHg to about 46 mmHg, (ii) between about 16 mmHg to about 46 mmHg, and/or (iii) about 24 mmHg. The maximum chest compression force value may be (i) between about 46 mmHg to about 86 mmHg, (ii) between about 46 mmHg to about 76 mmHg, and/or (iii) about 68 mmHg.

[0031] In some examples, the chest compression device 114 provides for improved cooling and/or preservation of the body 102, such as due, at least in part, to (i) increased blood circulation and/or movement through one or more portions of the body 102 (e.g., the lungs and/or heart) caused by chest compressions by the chest compression device 114 and/or (ii) increased blood perfusion associated with the body 102 caused by chest compressions by the chest compression device 114. [0032] In some examples, the cooling apparatus 100 may comprise a set of sensors (e.g., a set of one or more sensors). The set of sensors may comprise a first temperature sensor 172 configured to measure a body temperature 174 associated with the body 102. In some examples, the first temperature sensor 172 comprises a temperature sensing component placed proximal to (e.g., at and/or near) a part of the body 102 associated with the body temperature 174. In some examples, the body temperature 174 may correspond to a tracheal temperature associated with the body 102. The tracheal temperature may correspond to a temperature associated with a carina of the trachea of the body 102.

[0033] The set of sensors may comprise a blood pressure sensor 178 configured to measure a blood pressure 176 associated with the body 102. In some examples, the blood pressure sensor 178 comprises a sphygmomanometer, an inflatable cuff, a pressure gauge, a display for a digital readout, and/or other suitable component for measuring blood pressure. In some examples, spikes of the blood pressure 176 over time are associated with chest compressions performed by the chest compression device 114.

[0034] The set of sensors may comprise a second temperature sensor configured to measure the fluid temperature associated with the fluid 120. In some examples, the second temperature sensor comprises a temperature sensing component positioned along the fluid circuit. In some examples, the temperature sensing component may be positioned proximal to (e.g., at and/or near) (i) a conduit of the first set of conduits 180, (ii) a conduit of the second set of conduits 182, (iii) a conduit of the third set of conduits 184, (iv) a conduit of the fourth set of conduits 186 and/or (v) the vessel 104. In some examples, the temperature sensing component may be positioned in the chamber 103. In some examples, the temperature sensing component may be in contact with and/or at least partially submerged in the fluid 120 (within the chamber 103, for example), such while the fluid 120 is being circulated through the vessel 104 using the pump 112.

[0035] The set of sensors may comprise a flow rate sensor (e.g., a flow meter) configured to measure the fluid flow rate associated with the fluid 120 (circulating through the fluid circuit, for example). In some examples, the flow rate sensor (not shown) is positioned along the fluid circuit. In some examples, the flow rate sensor may be positioned proximal to (e.g., at and/or near) (i) a conduit of the first set of conduits 180, (ii) a conduit of the second set of conduits 182, (iii) a conduit of the third set of conduits 184, (iv) a conduit of the fourth set of conduits 186 and/or (v) the vessel 104. In some examples, the flow rate sensor may be positioned in the chamber 103.

[0036] In some examples, the controller 130 may determine one or more control parameters (e.g., at least one of the target flow rate, the target fluid temperature, the target chest compression rate, the target chest compression force, a target composition, etc.) based upon a target body temperature (e.g., a target tracheal temperature and/or target temperature of other portion of the body 102). The target body temperature may correspond to a target body temperature value and/or a target body temperature range. In some examples, the controller 130 may be configured to set one or more control parameters (e.g., at least one of the target flow rate, the target fluid temperature, the target chest compression rate, the target chest compression force, the target composition, etc.) to one or more respective values that result in the body temperature 174 matching the target body temperature. In some examples, the body temperature 174 may be considered to match the target body temperature when the body temperature 174 is about equal to (and/or within a threshold difference of) the target body temperature value.

Alternatively and/or additionally, the body temperature 174 may be considered to match the target body temperature when the body temperature 174 is within the target body temperature range. In some examples, using the cooling apparatus 100 to maintain the body temperature 174 based upon the target body temperature provides for improved cooling and/or preservation of the body 102.

[0037] In some examples, the target body temperature value (e.g., target tracheal temperature value) may be (i) between about 0 degrees Celsius to about 34 degrees Celsius, (ii) between about 4 degrees Celsius to about 30 degrees Celsius, (iii) between about 10 degrees Celsius to about 24 degrees Celsius), and/or (iv) about 17 degrees Celsius. In some examples, the target body temperature range (e.g., target tracheal temperature range) may range from a minimum body temperature value to a maximum body temperature value. The minimum body temperature value may be (i) between about 0 degrees Celsius to about 17 degrees Celsius, (ii) between about 4 degrees Celsius to about 17 degrees Celsius, and/or (iii) about 4 degrees Celsius. The maximum body temperature value may be (i) between about 17 degrees Celsius to about 34 degrees Celsius, (ii) between about 17 degrees Celsius to about 30 degrees Celsius, and/or (iii) about 30 degrees Celsius.

[0038] In some examples, the controller 130 may determine the target flow rate and/or generate a control signal S1 based upon the target flow rate. The control signal S1 may be indicative of the target flow rate. The controller 130 may transmit the control signal S1 to the pump 112. The pump 112 may operate based upon the control signal S1 (e.g., the pump 112 may control the fluid flow rate associated with the fluid 120 based upon the target flow rate indicated by the control signal S1). The controller 130 may determine the target flow rate based upon (i) the fluid temperature (determined using the second temperature sensor, for example) associated with the fluid 120, (ii) the body temperature 174 (determined using the first temperature sensor 172, for example) associated with the body 102, (iii) the fluid flow rate (determined using the flow rate sensor, for example) associated with the fluid 120, (iv) the blood pressure 176 (determined using the blood pressure sensor 178, for example), and/or (v) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the controller 130 may monitor one or more parameters (e.g., updated and/or current measurements) comprising (i) the fluid temperature, (ii) the body temperature 174, (iii) the fluid flow rate, (iv) the blood pressure 176, and/or (v) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the controller 130 may update (e.g., modify, such as increase and/or decrease) the target flow rate in response to detecting a change to a parameter of the one or more parameters (e.g., at least one of a change to the fluid temperature, a change to the body temperature 174, a change to the fluid flow rate, a change to the blood pressure 176, etc.). In response to updating the target flow rate from an initial target flow rate to an updated target flow rate, the controller 130 may update the control signal S1 to indicate the updated target flow rate to the pump 112. The pump 112 may adjust the fluid flow rate associated with the fluid 120 in response to the target flow rate being updated (e.g., the pump 112 may modify operation to increase or decrease the fluid flow rate to a rate that matches the updated target flow rate).

[0039] In some examples, the controller 130 may determine the target flow rate based upon a comparison of the body temperature 174 with the target body temperature. In some examples, the controller 130 may increase the target flow rate (e.g., change the target flow rate from an initial value to an increased value) in response to (i) the body temperature 174 being greater than a threshold (e.g., a threshold that is equal to and/or based upon the target body temperature) and/or (ii) the fluid temperature being greater than a threshold (e.g., a threshold that is equal to and/or based upon the target fluid temperature). In some examples, the controller 130 may decrease the target flow rate (e.g., change the target flow rate from an initial value to a decreased value) in response to (i) the body temperature 174 being less than a threshold (e.g., a threshold that is equal to and/or based upon the target body temperature) and/or (ii) the fluid temperature being less than a threshold (e.g., a threshold that is equal to and/or based upon the target fluid temperature).

[0040] In some examples, the controller 130 may determine the target fluid temperature and/or generate a control signal S2 based upon the target fluid temperature. The control signal S2 may be indicative of the target fluid temperature. The controller 130 may transmit the control signal S2 to the fluid temperature controller 116. The fluid temperature controller 116 may regulate the fluid temperature associated with the fluid 120 based upon the control signal S2 (e.g., the fluid temperature controller 1 16 may control the fluid temperature associated with the fluid 120 based upon the target fluid temperature indicated by the control signal S2). The controller 130 may determine the target fluid temperature based upon (i) the fluid temperature associated with the fluid 120, (ii) the body temperature 174 associated with the body 102, (iii) the fluid flow rate associated with the fluid 120, (iv) the blood pressure 176, and/or (v) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the controller 130 may monitor one or more parameters (e.g., updated and/or current measurements) comprising (i) the fluid temperature, (ii) the body temperature 174, (iii) the fluid flow rate, (iv) the blood pressure 176, and/or (v) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the controller 130 may update (e.g., modify, such as increase and/or decrease) the target fluid temperature in response to detecting a change to a parameter of the one or more parameters (e.g., at least one of a change to the fluid temperature, a change to the body temperature 174, a change to the fluid flow rate, a change to the blood pressure 176, etc.). In response to updating the target fluid temperature from an initial target fluid temperature to an updated target fluid temperature, the controller 130 may update the control signal S2 to indicate the updated target fluid temperature to the fluid temperature controller 116. The fluid temperature controller 1 16 may adjust the fluid temperature associated with the fluid 120 in response to the target fluid temperature being updated (e.g., the fluid temperature controller 116 may modify operation to increase or decrease the fluid temperature to a temperature that matches the updated target fluid temperature).

[0041] In some examples, the controller 130 may determine the target fluid temperature based upon a comparison of the body temperature 174 with the target body temperature. In some examples, the controller 130 may decrease the target fluid temperature (e.g., change the target fluid temperature from an initial value to a decreased value) in response to the body temperature 174 being greater than a threshold (e.g., a threshold that is equal to and/or based upon the target body temperature). In some examples, the controller 130 may increase the target fluid temperature (e.g., change the target fluid temperature from an initial value to an increased value) in response to the body temperature 174 being less than a threshold (e.g., a threshold that is equal to and/or based upon the target body temperature).

[0042] In some examples, the controller 130 may determine the target chest compression rate and/or the target chest compression force and/or may generate a control signal S3 based upon the target chest compression rate and/or the target chest compression force. The control signal S3 may be indicative of the target chest compression rate and/or the target chest compression force. The controller 130 may transmit the control signal S3 to the chest compression device 114. The chest compression device 114 may perform chest compressions on the body 102 based upon the control signal S3 (e.g., the chest compression device 114 may control the chest compression rate and/or the chest compression force with which the chest compression device 1 14 performs chest compressions on the body 102 based upon the target chest compression rate and/or the target chest compression force indicated by the control signal S3). The controller 130 may determine the target chest compression rate and/or the target chest compression force based upon (i) the fluid temperature associated with the fluid 120, (ii) the body temperature 174 associated with the body 102, (iii) the fluid flow rate associated with the fluid 120, (iv) the blood pressure 176, and/or (v) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the controller 130 may monitor one or more parameters (e.g., updated and/or current measurements) comprising (i) the fluid temperature, (ii) the body temperature 174, (iii) the fluid flow rate, (iv) the blood pressure 176, and/or (v) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the controller 130 may update (e.g., modify, such as increase and/or decrease) the target chest compression rate and/or the target chest compression force in response to detecting a change to a parameter of the one or more parameters (e.g., at least one of a change to the fluid temperature, a change to the body temperature 174, a change to the fluid flow rate, a change to the blood pressure 176, etc.).

[0043] In some examples, in response to updating the target chest compression rate from an initial target chest compression rate to an updated target chest compression rate, the controller 130 may update the control signal S3 to indicate the updated target chest compression rate to the chest compression device 1 14. In response to the target chest compression rate being updated to the updated target chest compression rate, the chest compression device 1 14 may adjust the chest compression rate with which the chest compression device 114 performs chest compressions on the body 102 (e.g., the chest compression device 114 may modify operation to increase or decrease the chest compression rate to a rate that matches the updated target chest compression rate).

[0044] In some examples, in response to updating the target chest compression force from an initial target chest compression force to an updated target chest compression force, the controller 130 may update the control signal S3 to indicate the updated target chest compression force to the chest compression device 114. In response to the target chest compression force being updated to the updated target chest compression force, the chest compression device 1 14 may adjust the chest compression force with which the chest compression device 114 performs chest compressions on the body 102 (e.g., the chest compression device 114 may modify operation to increase or decrease the chest compression force to a force that matches the updated target chest compression force).

[0045] In some examples, the controller 130 may determine the target chest compression rate and/or the target chest compression force based upon a comparison of the body temperature 174 with the target body temperature. In some examples, in response to the body temperature 174 being greater than a threshold (e.g., a threshold that is equal to and/or based upon the target body temperature), the controller 130 may (i) increase the target chest compression rate (e.g., change the target chest compression rate from an initial value to an increased value) and/or (ii) increase the target chest compression force (e.g., change the target chest compression force from an initial value to an increased value). In some examples, in response to the body temperature 174 being less than a threshold (e.g., a threshold that is equal to and/or based upon the target body temperature), the controller 130 may (i) decrease the target chest compression rate (e.g., change the target chest compression rate from an initial value to a decreased value) and/or (ii) decrease the target chest compression force (e.g., change the target chest compression force from an initial value to a decreased value).

[0046] In some examples, the controller 130 may determine the target composition and/or generate a control signal S4 based upon the target composition. The control signal S4 may be indicative of the target composition. The controller 130 may transmit the control signal S4 to the fluid composition controller 126. The fluid composition controller 126 may operate based upon the control signal S4 (e.g., the fluid composition controller 126 may control the fluid composition associated with the fluid 120 based upon the target composition indicated by the control signal S4). In some examples, the target composition is indicative of a target proportion of refrigerant relative to the fluid 120. The controller 130 may determine the target composition based upon (i) the fluid temperature associated with the fluid 120, (ii) the body temperature 174 associated with the body 102, (iii) the fluid flow rate associated with the fluid 120, (iv) the blood pressure 176, and/or (v) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the controller 130 may monitor one or more parameters (e.g., updated and/or current measurements) comprising (i) the fluid temperature, (ii) the body temperature 174, (iii) the fluid flow rate, (iv) the blood pressure 176, and/or (v) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the controller 130 may update (e.g., modify, such as increase and/or decrease) the target composition in response to detecting a change to a parameter of the one or more parameters (e.g., at least one of a change to the fluid temperature, a change to the body temperature 174, a change to the fluid flow rate, a change to the blood pressure 176, etc.). In response to updating the target composition from an initial target composition to an updated target composition, the controller 130 may update the control signal S4 to indicate the updated target composition to the fluid composition controller 126. The fluid composition controller 126 may adjust the fluid composition associated with the fluid 120 in response to the target composition being updated (e.g., the fluid composition controller 126 may at least one of introduce further refrigerant 144 into the fluid circuit, introduce further first fluid 134 into the fluid circuit, etc. to adjust the fluid composition associated with the fluid 120).

[0047] In some examples, the controller 130 may determine the target composition based upon a comparison of the body temperature 174 with the target body temperature. In some examples, the controller 130 may increase the target proportion of refrigerant relative to the fluid 120 in response to (i) the body temperature 174 being greater than a threshold (e.g., a threshold that is equal to and/or based upon the target body temperature) and/or (ii) the fluid temperature being greater than a threshold (e.g., a threshold that is equal to and/or based upon the target fluid temperature). In some examples, the controller 130 may decrease the target proportion of refrigerant relative to the fluid 120 in response to (i) the body temperature 174 being less than a threshold (e.g., a threshold that is equal to and/or based upon the target body temperature) and/or (ii) the fluid temperature being less than a threshold (e.g., a threshold that is equal to and/or based upon the target fluid temperature).

[0048] Figs. 2A-2B illustrate a support structure 210 of the cooling apparatus 100 in accordance with some examples. Fig. 2A illustrates a side view of the cooling apparatus 100 comprising the support structure 210, in accordance with some examples. The support structure 210 may be configured to support the body 102 in the target position relative to the vessel 104. In some examples, at least a portion of the body 102 is laid upon the support structure 210 to achieve the target position. In some examples, the support structure 210 comprises protrusions to support the body. In some examples, protrusions of the support structure 210 are spaced apart such that a pair of adjacent protrusions define a space between them. Fig. 2B illustrates a perspective view of a portion 230 of the support structure 210, in accordance with some examples. In some examples, the support structure 210 and/or protrusions of the support structure 210 are designed such that they are atraumatic and/or sufficiently structurally supportive to tolerate chest compression. In some examples, the support structure 210 comprises a first protrusion 232a (e.g., a first post, bump, spike, etc.) and/or a second protrusion 232b (e.g., a second post, bump, spike, etc.). There may be a space 234 between the first protrusion 232a and/or the second protrusion 232b. In some examples, the fluid 120 flows through the space 234 (in the direction 109 shown in Fig. 1 , for example). In some examples, the fluid 120 contacts the body 102 while flowing through the space 234. In some examples, the support structure 210 provides for an increased amount of surface area of the body 102 that is in contact with the fluid 120 (since the fluid 120 can flow through spaces between protrusions while the protrusions support the body 102 such that more of the fluid 120 can contact the body 102, for example), which may provide for (i) improved absorption of heat by the fluid 120 from the body 102 and/or (ii) improved preservation of the body 102. In some examples, the support structure 210 may comprise at least one of a rigid open-cell foam, a corrugated structure, or a mat with protrusions.

[0049] In some examples, the controller 130 may determine one or more viability statuses associated with one or more organs of the body 102 based upon (i) a time since death (e.g., a duration of time since the donor experienced circulatory death), (ii) the fluid temperature, (iii) the body temperature 174, (iv) the fluid flow rate, (v) the blood pressure 176, and/or (vi) other suitable parameter associated with the fluid 120 and/or the body 102. In some examples, the one or more viability statuses may comprise a first viability status associated with a first organ (e.g., the lungs of the body 102) and/or a second viability status associated with a second organ (e.g., the heart of the body 102). In some examples, the controller 130 may transmit content indicative of the viability statuses to one or more computing devices (not shown). In some examples, a computing device of the one or more computing devices may display a representation of the content via a display device (e.g., a monitor, a touchscreen, etc.). For example, the representation may be indicative of the first viability status and/or the second viability status. The first viability status may correspond to a likelihood that transplantation of the first organ would result in a positive outcome. The second viability status may correspond to a likelihood that transplantation of the second organ would result in a positive outcome. Thus, in some examples, a healthcare professional may use the representation to accurately determine whether to carry out the transplantation of the first organ and/or the second organ.

[0050] Fig. 3 illustrates the cooling apparatus 100 comprising a first bag 304 (e.g., a body bag) defining a chamber 303 through which the fluid 120 is circulated, in accordance with some examples. In some examples, the fluid 120 is emitted into the chamber 303 and/or onto the body 102 though the set of outlets (e.g., the first outlet 192 and/or the second outlet 194). In some examples, the first bag 304 may be at least partially sealed to mitigate (e.g., prevent and/or reduce) escape of the fluid 120 from the fluid circuit established by the cooling apparatus 100. In some examples, the first bag 304 comprises one or more materials (e.g., one or more plastics, flexible materials and/or other materials) that mitigate heat transfer from outside the first bag 304 to the body 102.

[0051] In some examples, the fluid 120 may flow through the chamber 303 defined by the first bag 304 in a direction 309. In some examples, while the fluid 120 is in the chamber 303 (and/or while the fluid 120 is flowing in the direction 309), the fluid 120 is in contact with the body 102. In some examples, the fluid 120 absorbs heat from the body 102 to cool and/or preserve the body 102. In some examples, the fluid 120 cools the body 102 via saturation of the fluid 120 with the body 102. In some examples, the fluid 120 may exit the first bag 304 through the first set of conduits 180. For example, the fluid 120 may flow through an outlet 321 defined by the first bag 304 into the first set of conduits 180.

[0052] In some examples, one, some or all of the techniques provided herein with respect to Fig. 1 may be used to implement the cooling apparatus 100 comprising the first bag 304 (shown in Fig. 3).

[0053] Fig. 4 illustrates the cooling apparatus 100 comprising a second bag 404 (e.g., an outer bag) defining a chamber 403 through which the fluid 120 is circulated, in accordance with some examples. In some examples, the body 102 is positioned in a third bag 414 (e.g., an inner bag) in the second bag 404. In some examples, the fluid 120 is emitted into the chamber 403 though the set of outlets (e.g., the first outlet 192 and/or the second outlet 194). In some examples, the third bag 414 may be at least partially sealed to mitigate (e.g., prevent and/or reduce) contact of the fluid 120 with the body 120. In some examples, the third bag 414 comprises one or more materials (e.g., one or more plastics, flexible materials and/or other materials) that allow transfer of heat from the body 120 through the bag to the fluid 120. In some examples, the fluid 120 absorbs heat from the body 102 through the third bag 414. In some examples, the fluid 120 may flow through the chamber 403 defined by the second bag 404 in a direction 409. In some examples, a first portion 120a of the fluid 120 flows along a first flow path and/or absorbs heat from one or more first portions of the body 102. In some examples, at least some of the first portion 120a of the fluid 120 flows through openings between protrusions of the support structure 210 (not shown in Fig. 4). Alternatively and/or additionally, a second portion 120b of the fluid 120 flows along a second flow path and/or absorbs heat from one or more second portions of the body 102. In some examples, the second bag 404 may be at least partially sealed to mitigate (e.g., prevent and/or reduce) escape of the fluid 120 from the fluid circuit established by the cooling apparatus 100. In some examples, the second bag 404 comprises one or more materials (e.g., one or more plastics, flexible materials and/or other materials) that mitigate heat transfer from outside the second bag 404 to the body 102. In some examples, the fluid 120 may exit the first bag 304 through the first set of conduits 180. For example, the fluid 120 may flow through an outlet 421 defined by the first bag 304 into the first set of conduits 180.

[0054] In some examples, one, some or all of the techniques provided herein with respect to Fig. 1 may be used to implement the cooling apparatus 100 comprising the second bag 404 and/or the third bag 414 (shown in Fig. 4).

[0055] In some examples, using the cooling apparatus 100 in accordance with the present disclosure provides for (i) extending a viable window associated with transplantation of one or more organs (e.g., at least one of the lungs, the heart, the liver, a kidney, etc.) of the body 102 such that the one or more organs are viable for transplantation for longer, thereby expanding the organ donor pool (e.g., lung donor pool, heart donor pool, liver donor pool, kidney donor pool, etc.), and/or (ii) protecting one or more organs (e.g., at least one of the lungs, the heart, the liver, the kidney, etc.) of the body 102 from ischemia reperfusion injury and/or warm ischemia injury, thereby improving transplantation outcome associated with the one or more organs. In some examples, the cooling apparatus 100 may be implemented efficiently (with minimal required support equipment, for example). In some examples, transplantation of one or more organs of the body 102 is performed in response to a determination (e.g., based upon the one or more viability statuses) that the one or more organs are viable. In an example, the transplantation comprises a lung transplant (LTx), such as a transplantation of uDCD lungs. Other types of transplantation of the transplantation are within the scope of the present disclosure.

[0056] In some embodiments, each conduit of one, some, or all conduits of the present disclosure (i) is used for transferring fluids and/or (ii) comprises at least one of one or more tubes, one or more pipes, one or more fluid transport lines, one or more fluid transport hoses, one or more manifolds, etc.

[0057] An embodiment of cooling and/or preserving the body 102 is illustrated by an example method 500 of Fig. 5. At 502, a fluid (e.g., the fluid 120) may be circulated through a vessel (e.g., the vessel 104, the first bag 304, the second bag 404, etc.) using a pump (e.g., the pump 112) while the body 102 is in the vessel (e.g., while the body 102 is in the target position). At 504, a chest compression device (e.g., the chest compression device 1 14) may perform chest compressions on the body 102 while the body 102 is in the vessel (e.g., while the body 102 is in the target position).

[0058] Fig. 6 is an illustration of a scenario 600 involving an example non- transitory machine readable medium 602. The non-transitory machine readable medium 602 may comprise processor-executable instructions 612 that when executed by a processor 616 cause performance (e.g., by the processor 616) of at least some of the provisions herein (e.g., embodiment 614).

[0059] The non-transitory machine readable medium 602 may comprise a memory semiconductor (e.g., a semiconductor utilizing static random access memory (SRAM), dynamic random access memory (DRAM), and/or synchronous dynamic random access memory (SDRAM) technologies), a platter of a hard disk drive, a flash memory device, or a magnetic or optical disc (such as a compact disc (CD), digital versatile disc (DVD), or floppy disk).

[0060] The example non-transitory machine readable medium 602 stores computer-readable data 604 that, when subjected to reading 606 by a reader 610 of a device 608 (e.g., a read head of a hard disk drive, or a read operation invoked on a solid-state storage device), express the processorexecutable instructions 612. [0061] In some embodiments, the processor-executable instructions 612, when executed, cause performance of operations, such as at least some of the example method 500 of Fig. 5, for example. In some embodiments, the processor-executable instructions 612 are configured to cause implementation of a system comprising at least some of the example cooling apparatus 100.

[0062] According to some embodiments, a cooling apparatus is provided. The cooling apparatus includes a vessel; and a pump configured to circulate a fluid through the vessel while a body of a donor is in the vessel.

[0063] According to some embodiments, the fluid absorbs heat from the body.

[0064] According to some embodiments, the fluid includes a refrigerant.

[0065] According to some embodiments, the cooling apparatus includes a fluid temperature controller configured to regulate a fluid temperature associated with the fluid based upon a target temperature.

[0066] According to some embodiments, the cooling apparatus includes a temperature sensor configured to measure a body temperature associated with the body, wherein the target temperature is based upon the body temperature.

[0067] According to some embodiments, the body temperature corresponds to a tracheal temperature associated with the body.

[0068] According to some embodiments, the cooling apparatus includes a chest compression device configured to perform chest compressions on the body.

[0069] According to some embodiments, the cooling apparatus includes a temperature sensor configured to measure a body temperature associated with the body, wherein a chest compression rate with which the chest compression device performs chest compressions on the body is based upon the body temperature.

[0070] According to some embodiments, the body temperature corresponds to a tracheal temperature associated with the body. [0071] According to some embodiments, the cooling apparatus includes a support structure including protrusions to support the body, wherein the fluid flows through a space between a first protrusion of the support structure and a second protrusion of the support structure.

[0072] According to some embodiments, the vessel includes a basin.

[0073] According to some embodiments, the vessel includes a bag.

[0074] According to some embodiments, a method is provided. The method includes circulating, using a pump, a fluid through a vessel while a body of a donor is in the vessel; and performing, using a chest compression device, chest compressions on the body while the body is in the vessel.

[0075] According to some embodiments, the fluid absorbs heat from the body.

[0076] According to some embodiments, the fluid includes a refrigerant.

[0077] According to some embodiments, the method includes regulating, using a fluid temperature controller, a fluid temperature associated with the fluid based upon a target temperature.

[0078] According to some embodiments, the method includes measuring, using a temperature sensor, a body temperature associated with the body; and determining the target temperature based upon the body temperature.

[0079] According to some embodiments, the body temperature corresponds to a tracheal temperature associated with the body.

[0080] According to some embodiments, the method includes performing, using a chest compression device, chest compressions on the body.

[0081] According to some embodiments, the method includes measuring, using a temperature sensor, a body temperature associated with the body; determining a chest compression rate based upon the body temperature; and performing chest compressions on the body using the chest compression device based upon the chest compression rate.

[0082] According to some embodiments, the body temperature corresponds to a tracheal temperature associated with the body. [0083] According to some embodiments, a cooling apparatus is provided. The cooling apparatus includes a vessel; and a pump connected to the vessel via a first set of conduits and a second set of conduits, wherein the pump is configured to pump a fluid into the vessel via the first set of conduits while a body of a donor is in the vessel, wherein the fluid exits the vessel through the second set of conduits.

[0084] According to some embodiments, the fluid absorbs heat from the body.

[0085] According to some embodiments, the fluid includes a refrigerant.

[0086] According to some embodiments, the cooling apparatus includes a fluid temperature controller configured to regulate a fluid temperature associated with the fluid based upon a target temperature.

[0087] According to some embodiments, the cooling apparatus includes a temperature sensor configured to measure a body temperature associated with the body, wherein the target temperature is based upon the body temperature.

[0088] According to some embodiments, the body temperature corresponds to a tracheal temperature associated with the body.

[0089] According to some embodiments, the cooling apparatus includes a chest compression device configured to perform chest compressions on the body.

[0090] According to some embodiments, the cooling apparatus includes a temperature sensor configured to measure a body temperature associated with the body, wherein a chest compression rate with which the chest compression device performs chest compressions on the body is based upon the body temperature.

[0091] According to some embodiments, the body temperature corresponds to a tracheal temperature associated with the body.

[0092] According to some embodiments, the cooling apparatus includes a support structure comprising protrusions to support the body, wherein the fluid flows through a space between a first protrusion of the support structure and a second protrusion of the support structure.

[0093] According to some embodiments, the vessel includes a basin.

[0094] According to some embodiments, the vessel includes a bag.

[0095] According to some embodiments, a method is provided wherein the method includes at least one aspect as described in the present disclosure and/or shown in the figures.

[0096] According to some embodiments, a method is provided wherein the method includes plural aspects as described in the present disclosure and/or shown in the figures.

[0097] According to some embodiments, an apparatus is provided wherein the apparatus includes at least one aspect as described in the present disclosure and/or shown in the figures.

[0098] According to some embodiments, an apparatus is provided wherein the apparatus includes plural aspects as described in the present disclosure and/or shown in the figures.

[0099] As used in this application, "component," "module," "system", "interface", and/or the like are generally intended to refer to a computer- related entity, either hardware, a combination of hardware and software, software, or software in execution. For example, a component may be, but is not limited to being, a process running on a processor, a processor, an object, an executable, a thread of execution, a program, and/or a computer. By way of illustration, both an application running on a controller and the controller can be a component. One or more components may reside within a process and/or thread of execution and a component may be localized on one computer and/or distributed between two or more computers.

[00100] Unless specified otherwise, “first,” “second,” and/or the like are not intended to imply a temporal aspect, a spatial aspect, an ordering, etc. Rather, such terms are merely used as identifiers, names, etc. for features, elements, items, etc. For example, a first object and a second object generally correspond to object A and object B or two different or two identical objects or the same object.

[00101] Moreover, "example" is used herein to mean serving as an instance, illustration, etc., and not necessarily as advantageous. As used herein, "or" is intended to mean an inclusive "or" rather than an exclusive "or". In addition, "a" and "an" as used in this application are generally be construed to mean "one or more" unless specified otherwise or clear from context to be directed to a singular form. Also, at least one of A and B and/or the like generally means A or B or both A and B. Furthermore, to the extent that "includes", "having", "has", "with", and/or variants thereof are used in either the detailed description or the claims, such terms are intended to be inclusive in a manner similar to the term "comprising".

[00102] Although the subject matter has been described in language specific to structural features and/or methodological acts, it is to be understood that the subject matter defined in the appended claims is not necessarily limited to the specific features or acts described above. Rather, the specific features and acts described above are disclosed as example forms of implementing at least some of the claims.

[00103] Furthermore, the claimed subject matter may be implemented as a method, apparatus, or article of manufacture using standard programming and/or engineering techniques to produce software, firmware, hardware, or any combination thereof to control a computer to implement the disclosed subject matter. The term "article of manufacture" as used herein is intended to encompass a computer program accessible from any computer- readable device, carrier, or media. Of course, many modifications may be made to this configuration without departing from the scope or spirit of the claimed subject matter.

[00104] Various operations of embodiments are provided herein. In an embodiment, one or more of the operations described may constitute computer readable instructions stored on one or more computer and/or machine readable media, which if executed will cause the operations to be performed. The order in which some or all of the operations are described should not be construed as to imply that these operations are necessarily order dependent. Alternative ordering will be appreciated by one skilled in the art having the benefit of this description. Further, it will be understood that not all operations are necessarily present in each embodiment provided herein. Also, it will be understood that not all operations are necessary in some embodiments.

[00105] Also, although the disclosure has been shown and described with respect to one or more implementations, equivalent alterations and modifications will occur to others skilled in the art based upon a reading and understanding of this specification and the annexed drawings. The disclosure includes all such modifications and alterations and is limited only by the scope of the following claims. In particular regard to the various functions performed by the above described components (e.g., elements, resources, etc.), the terms used to describe such components are intended to correspond, unless otherwise indicated, to any component which performs the specified function of the described component (e.g., that is functionally equivalent), even though not structurally equivalent to the disclosed structure. In addition, while a particular feature of the disclosure may have been disclosed with respect to only one of several implementations, such feature may be combined with one or more other features of the other implementations as may be desired and advantageous for any given or particular application.

Claims

CLAIMS What is claimed is:

1 . A cooling apparatus, comprising: a vessel; and a pump configured to circulate a fluid through the vessel while a body of a donor is in the vessel.

2. The cooling apparatus of claim 1 , wherein: the fluid absorbs heat from the body.

3. The cooling apparatus of claim 1 , wherein: the fluid comprises a refrigerant.

4. The cooling apparatus of claim 1 , comprising: a fluid temperature controller configured to regulate a fluid temperature associated with the fluid based upon a target temperature.

5. The cooling apparatus of claim 4, comprising: a temperature sensor configured to measure a body temperature associated with the body, wherein the target temperature is based upon the body temperature.

6. The cooling apparatus of claim 5, wherein: the body temperature corresponds to a tracheal temperature associated with the body.

7. The cooling apparatus of claim 1 , comprising: a chest compression device configured to perform chest compressions on the body.

8. The cooling apparatus of claim 7, comprising: a temperature sensor configured to measure a body temperature associated with the body, wherein a chest compression rate with which the chest compression device performs chest compressions on the body is based upon the body temperature.

9. The cooling apparatus of claim 8, wherein: the body temperature corresponds to a tracheal temperature associated with the body.

10. The cooling apparatus of claim 1 , comprising: a support structure comprising protrusions to support the body, wherein the fluid flows through a space between a first protrusion of the support structure and a second protrusion of the support structure.

11 . The cooling apparatus of claim 1 , wherein: the vessel comprises a basin.

12. The cooling apparatus of claim 1 , wherein: the vessel comprises a bag.

13. A method, comprising: circulating, using a pump, a fluid through a vessel while a body of a donor is in the vessel; and performing, using a chest compression device, chest compressions on the body while the body is in the vessel.

14. The method of claim 13, wherein: the fluid absorbs heat from the body.

15. The method of claim 13, wherein: the fluid comprises a refrigerant.

16. The method of claim 13, comprising: regulating, using a fluid temperature controller, a fluid temperature associated with the fluid based upon a target temperature.

17. The method of claim 16, comprising: measuring, using a temperature sensor, a body temperature associated with the body; and determining the target temperature based upon the body temperature.

18. The method of claim 17, wherein: the body temperature corresponds to a tracheal temperature associated with the body.

19. The method of claim 13, comprising: performing, using a chest compression device, chest compressions on the body.

20. The method of claim 19, comprising: measuring, using a temperature sensor, a body temperature associated with the body; determining a chest compression rate based upon the body temperature; and performing chest compressions on the body using the chest compression device based upon the chest compression rate.

21 . The method of claim 20, wherein: the body temperature corresponds to a tracheal temperature associated with the body.

22. A cooling apparatus, comprising: a vessel; and a pump connected to the vessel via a first set of conduits and a second set of conduits, wherein the pump is configured to pump a fluid into the vessel via the first set of conduits while a body of a donor is in the vessel, wherein the fluid exits the vessel through the second set of conduits.

23. The cooling apparatus of claim 22, wherein: the fluid absorbs heat from the body.

24. The cooling apparatus of claim 22, wherein: the fluid comprises a refrigerant.

25. The cooling apparatus of claim 22, comprising: a fluid temperature controller configured to regulate a fluid temperature associated with the fluid based upon a target temperature.

26. The cooling apparatus of claim 25, comprising: a temperature sensor configured to measure a body temperature associated with the body, wherein the target temperature is based upon the body temperature.

27. The cooling apparatus of claim 26, wherein: the body temperature corresponds to a tracheal temperature associated with the body.

28. The cooling apparatus of claim 22, comprising: a chest compression device configured to perform chest compressions on the body.

29. The cooling apparatus of claim 28, comprising: a temperature sensor configured to measure a body temperature associated with the body, wherein a chest compression rate with which the chest compression device performs chest compressions on the body is based upon the body temperature.

30. The cooling apparatus of claim 29, wherein: the body temperature corresponds to a tracheal temperature associated with the body.

31 . The cooling apparatus of claim 22, comprising: a support structure comprising protrusions to support the body, wherein the fluid flows through a space between a first protrusion of the support structure and a second protrusion of the support structure.

32. The cooling apparatus of claim 22, wherein: the vessel comprises a basin.

33. The cooling apparatus of claim 22, wherein: the vessel comprises a bag.

34. A method, comprising: at least one aspect as described in any one of the preceding claims.

35. A method, comprising: at least one aspect as described in any combination of some or all of the preceding claims.

36. A method, comprising: plural aspects as described in any one of the preceding claims.

37. A method, comprising: plural aspects as described in any combination of some or all of the preceding claims.

38. An apparatus, comprising: at least one aspect as described in any one of the preceding claims.

39. An apparatus, comprising: at least one aspect as described in any combination of some or all of the preceding claims.

40. An apparatus, comprising: plural aspects as described in any one of the preceding claims.

41 . An apparatus, comprising: plural aspects as described in any combination of some or all of the preceding claims.