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WO2025056912A3 - Biomimetic device - Google Patents

Biomimetic device Download PDF

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Publication number
WO2025056912A3
WO2025056912A3 PCT/GB2024/052382 GB2024052382W WO2025056912A3 WO 2025056912 A3 WO2025056912 A3 WO 2025056912A3 GB 2024052382 W GB2024052382 W GB 2024052382W WO 2025056912 A3 WO2025056912 A3 WO 2025056912A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel
pillars
mould
base
biomimetic device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/GB2024/052382
Other languages
French (fr)
Other versions
WO2025056912A2 (en
Inventor
Soufian LASLI
Emad MOEENDARBARY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCL Business Ltd
Original Assignee
UCL Business Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCL Business Ltd filed Critical UCL Business Ltd
Publication of WO2025056912A2 publication Critical patent/WO2025056912A2/en
Publication of WO2025056912A3 publication Critical patent/WO2025056912A3/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A method of manufacturing a biomimetic device (100) suitable for myelination assays, the method comprising: forming a plurality of pillars (110) extending from a base (112), the plurality of pillars (110) and the base (112) comprising a hydrogel material (114), wherein forming the plurality of pillars (110) and the base (112) comprises: applying an uncured hydrogel precursor material (114a) to a mould; curing the hydrogel precursor material (114a) to form a hydrogel material (114) in the mould; and removing the hydrogel material (114) from the mould.
PCT/GB2024/052382 2023-09-13 2024-09-12 Biomimetic device Pending WO2025056912A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2314005.6A GB202314005D0 (en) 2023-09-13 2023-09-13 Biomimetic device
GB2314005.6 2023-09-13

Publications (2)

Publication Number Publication Date
WO2025056912A2 WO2025056912A2 (en) 2025-03-20
WO2025056912A3 true WO2025056912A3 (en) 2025-04-24

Family

ID=88412685

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2024/052382 Pending WO2025056912A2 (en) 2023-09-13 2024-09-12 Biomimetic device

Country Status (2)

Country Link
GB (1) GB202314005D0 (en)
WO (1) WO2025056912A2 (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011163551A2 (en) * 2010-06-25 2011-12-29 Cornell University Biomimetic tissue scaffold and methods of making and using same
US8535879B2 (en) * 2006-06-08 2013-09-17 Dwi An Der Rwth Aachen E.V. Structuring hydrogels
US20140141503A1 (en) * 2012-11-20 2014-05-22 Corning Incorporated Cell culture substrate having uniform surface coating
US20150316539A1 (en) * 2012-12-19 2015-11-05 The Regents Of The University Of California Micropillar Arrays for Assaying Myelination
US20170355945A1 (en) * 2016-06-13 2017-12-14 Massachusetts Institute Of Technology Microfluidic Device for Three Dimensional and Compartmentalized Coculture of Neuronal and Muscle Cells, with Functional Force Readout
US20180327715A1 (en) * 2017-05-10 2018-11-15 Massachusetts Institute Of Technology Engineered 3D-Printed Artificial Axons
US20200017823A1 (en) * 2018-07-13 2020-01-16 Wisconsin Alumni Research Foundation Hydrogel compositions for use in neural cell expansion and differentiation
CN114920955A (en) * 2022-04-29 2022-08-19 中国科学院深圳先进技术研究院 A hydrogel scaffold for three-dimensional culture of primary nerve cells in vitro and its preparation method and application
US20220372446A1 (en) * 2019-10-30 2022-11-24 The General Hospital Corporation High-throughput culture of ipsc-derived alveolar cells

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8535879B2 (en) * 2006-06-08 2013-09-17 Dwi An Der Rwth Aachen E.V. Structuring hydrogels
WO2011163551A2 (en) * 2010-06-25 2011-12-29 Cornell University Biomimetic tissue scaffold and methods of making and using same
US20140141503A1 (en) * 2012-11-20 2014-05-22 Corning Incorporated Cell culture substrate having uniform surface coating
US20150316539A1 (en) * 2012-12-19 2015-11-05 The Regents Of The University Of California Micropillar Arrays for Assaying Myelination
US20170355945A1 (en) * 2016-06-13 2017-12-14 Massachusetts Institute Of Technology Microfluidic Device for Three Dimensional and Compartmentalized Coculture of Neuronal and Muscle Cells, with Functional Force Readout
US20180327715A1 (en) * 2017-05-10 2018-11-15 Massachusetts Institute Of Technology Engineered 3D-Printed Artificial Axons
US20200017823A1 (en) * 2018-07-13 2020-01-16 Wisconsin Alumni Research Foundation Hydrogel compositions for use in neural cell expansion and differentiation
US20220372446A1 (en) * 2019-10-30 2022-11-24 The General Hospital Corporation High-throughput culture of ipsc-derived alveolar cells
CN114920955A (en) * 2022-04-29 2022-08-19 中国科学院深圳先进技术研究院 A hydrogel scaffold for three-dimensional culture of primary nerve cells in vitro and its preparation method and application

Also Published As

Publication number Publication date
GB202314005D0 (en) 2023-10-25
WO2025056912A2 (en) 2025-03-20

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