[go: up one dir, main page]

WO2025049851A1 - Procédé de production d'un revêtement sur la peau - Google Patents

Procédé de production d'un revêtement sur la peau Download PDF

Info

Publication number
WO2025049851A1
WO2025049851A1 PCT/US2024/044589 US2024044589W WO2025049851A1 WO 2025049851 A1 WO2025049851 A1 WO 2025049851A1 US 2024044589 W US2024044589 W US 2024044589W WO 2025049851 A1 WO2025049851 A1 WO 2025049851A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
composition
mass
fiber
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/044589
Other languages
English (en)
Inventor
Asuka IMAI
Adam Schrott
Rachel FULLENKAMP
Andrea SCHULTZ
Chika FURUTANI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Publication of WO2025049851A1 publication Critical patent/WO2025049851A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/027—Fibers; Fibrils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/83—Electrophoresis; Electrodes; Electrolytic phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application

Definitions

  • the present invention relates to a method for producing a coating on skin.
  • the method is particularly useful in the treatment of various skin conditions, such as eczema, psoriasis, rosacea, and seborrheic dermatitis.
  • Skin conditions are common among the human population.
  • skin conditions include eczema, psoriasis, rosacea, and seborrheic dermatitis.
  • eczema is an inflammatory skin condition that causes itchiness, dry skin, rashes, scaly patches, blisters and skin infections. Itchy skin is the most common symptom of eczema.
  • There are several different types of eczema including atopic dermatitis, contact dermatitis, dyshidrotic eczema, neurodermatitis, nummular eczema, seborrheic dermatitis and stasis dermatitis.
  • Atopic dermatitis the most common type of eczema, results from an overactive immune system that causes the skin barrier to become dry and itchy.
  • Eczema can begin during childhood, adolescence, or adulthood, and it can range from mild to severe. Newborn babies can experience eczema within the first weeks and months after birth. Young children with eczema can experience patches of skin that are extremely dry, and itchy skin that can lead to blisters and skin infections due to excessive scratching. Adults can also experience eczema and adult eczema most commonly develops when someone is in their 20s or over the age of 50. Many people with eczema use the phrase “flare-up” to describe a phase of eczema when they are experiencing one or more acute symptoms or side effects from prolonged itchiness. Severe eczema may include periods of flare-ups that can last many days or even several weeks.
  • Moisturizers, antihistamines, topical steroid creams and corticosteroids are among the potential courses of eczema treatments usually recommended by healthcare providers, dermatologists and the American Academy of Dermatology (AAD).
  • AAD American Academy of Dermatology
  • eczema treatments that are broadly applicable to a wide range of different patients remain elusive.
  • the present invention provides a method of producing a coating on skin, the method comprising (i) and (ii):
  • the present invention also provides a method of producing a coating on skin, the method comprising (i) and (ii):
  • the present invention also provides a method of treating eczema, the method comprising
  • the present invention also provides a method of treating skin conditions, such as eczema, comprising: applying a composition onto a surface of skin, wherein the composition comprises:
  • FIG. l is a schematic diagram showing the structure of an electrostatic spray device suitably used in the present invention.
  • FIG. 2 is a schematic diagram showing a situation in which an electrostatic spray method is carried out using the electrostatic spray device of FIG. 1 .
  • FIG. 3 is a schematic diagram showing the structure of an electrostatic spray device suitable for forming a sheet composed of a fiber deposit.
  • FIG. 4 shows experimental data on the change in itching over time when using methods according to the present application.
  • eczema can be effectively treated through a combination of a composition (for instance, a topical composition) containing horse chestnut seed extract (“HCE”) and a fiber deposit applied to the skin.
  • a composition for instance, a topical composition
  • HCE horse chestnut seed extract
  • the fiber deposit can be applied to the skin either before or after the topical composition containing HCE is applied to the skin.
  • the fiber deposit can be applied to the skin by applying a composition onto the skin to form the fiber deposit, or by placing a pre-formed sheet composed of a fiber deposit onto the skin.
  • the present invention provides a method of producing a coating on skin, the method comprising (i) and (ii):
  • the present invention provides a method of producing a coating on skin, the method comprising (i) and (ii):
  • the present invention provides a method of treating eczema, the method comprising (i) and (ii): (i) applying a first composition onto a surface of skin affected by eczema to form a coating composed of a deposit containing a fiber, and
  • the present invention provides a method of treating skin conditions, such as eczema, comprising: applying a composition onto a surface of skin, wherein the composition comprises:
  • the fiber deposit can be applied to the skin either before the HCE is applied to the skin or after the HCE is applied to the skin.
  • the fiber deposit can be applied to the skin by applying a composition onto the skin to form the fiber deposit, or by placing a pre-formed sheet composed of a fiber deposit onto the skin.
  • the composition that is applied onto the skin to form the fiber deposit is electrostatically sprayed onto the skin.
  • the method of applying the fiber deposit to the skin is not particularly limited as long as it is a method capable of forming a coating containing the fiber deposit on the skin. Specific examples thereof include the following means (1) to (3):
  • a step of electrostatically spraying a composition X comprising the following components (a) and (b) to the skin: (a) one or more volatile substances selected from the group consisting of water, alcohols, and ketones; and
  • a polymer having a coating formability i.e., an ability to form a coating containing a fiber deposit.
  • composition Z comprising the following components (c), (d) and optionally (e):
  • the method for applying the fiber deposit to the skin used in the means (1) is an electrostatic spray method.
  • the electrostatic spray method is a method in which a positive or negative high voltage is applied to a composition to charge the composition, and the charged composition is sprayed toward an object.
  • the sprayed composition spreads onto the space while repeating miniaturization by Coulomb repulsion.
  • the solvent which is a volatile substance, is dried to thereby form a film containing a fiber deposit on the surface of the object.
  • This means (1) can be carried out using the methods and devices disclosed, for example, in US 2021/0128896, WO 2018/194143, WO 2018/194140, and WO 2019/103974.
  • the component (a) contained in the composition X used in the means (1) is one or more volatile substances selected from the group consisting of water, an alcohol, and a ketone.
  • the volatile substance as the component (a) is a substance which is volatile in the liquid state.
  • the component (a) is mixed in the composition X for the purpose that the component (a) is discharged from the tip of a nozzle toward the skin after the composition X placed in the electric field is sufficiently charged; as the component (a) evaporates, the charge density of the composition X becomes excessive; the component (a) further evaporates while being further miniaturized due to Coulomb repulsion; and finally a dry film containing a fiber deposit is formed on the skin.
  • the vapor pressure of the volatile substance at 20°C.
  • kPa or more and 106.66 kPa or less is preferably 0.01 kPa or more and 106.66 kPa or less, more preferably 0.13 kPa or more and 66.66 kPa or less, further more preferably 0.67 kPa or more and 40.00 kPa or less, and even more preferably 1.33 kPa or more and 40.00 kPa or less.
  • examples of preferably used alcohols include monovalent chain aliphatic alcohols, monovalent cyclic aliphatic alcohols, and monovalent aromatic alcohols.
  • examples of the monovalent chain aliphatic alcohols include Ci- C& alcohols
  • examples of the monovalent cyclic aliphatic alcohols include C4-C6 cyclic alcohols
  • examples of the monovalent aromatic alcohols include benzyl alcohol, and phenylethyl alcohol. Specific examples thereof include ethanol, isopropyl alcohol, butyl alcohol, phenylethyl alcohol, n-propanol, and n-pentanol.
  • One or more of these alcohols can be used.
  • ketones include di-Ci- C4 alkyl ketones, such as acetone, methyl ethyl ketone, and methyl isobutyl ketone. These ketones can be used singly or in combination of two or more.
  • the volatile substance as the component (a) is more preferably one or more selected from the group consisting of ethanol, isopropyl alcohol, butyl alcohol, and water; more preferably one or more selected from the group consisting of ethanol and butyl alcohol; and even more preferably a volatile substance containing at least ethanol.
  • the volatile substance as the component (a) more preferably contains water, from the viewpoint of imparting charge.
  • the water content based on the total amount of the volatile substances is preferably 0.01% by mass or more, and more preferably 0.04% by mass or more, from the viewpoint of imparting charge; and is preferably 10% by mass or less, and more preferably 5% by mass or less, from the viewpoint of fiber-forming properties.
  • the content of the component (a) in the composition X is preferably 30% by mass or more, more preferably 55% by mass or more, and even more preferably 60% by mass or more. Moreover, from the viewpoint of fiber-forming properties, the content of the component (a) in the composition X is preferably 98% by mass or less, more preferably 96% by mass or less, and even more preferably 94% by mass or less. When an oil, a polyol, or the like is contained, the content of the component (a) is preferably 90% by mass or less, and more preferably 85% by mass or less.
  • the content of the component (a) in the composition X is preferably 30% by mass or more and 98% by mass or less, more preferably 55% by mass or more and 96% by mass or less, and even more preferably 60% by mass or more and 94% by mass or less.
  • the content of the component (a) in the composition X is preferably 30% by mass or more and 90% by mass or less, more preferably 55° by mass or more and 90° by mass or less, and even more preferably 60% by mass or more and 90% by mass or less. It is preferable that the composition X comprises the component (a) at this ratio, from the viewpoint of the volatility of the composition X when an electrostatic spray method is carried out.
  • the amount of ethanol is preferably 50% by mass or more, more preferably 65% by mass or more, and even more preferably 80% by mass or more, based on the total amount of the volatile substances as the component (a). Moreover, the amount of ethanol is preferably 100% by mass or less. The amount of ethanol is preferably 50% by mass or more and 100% by mass or less, more preferably 65% by mass or more and 100% by mass or less, and even more preferably 80% by mass or more and 100% by mass or less, based on the total amount of the volatile substances as the component (a).
  • the volatile substances comprise or consist of ethanol, water, or both.
  • the amount of the volatile substances may be 50% by mass ethanol and 50% by mass water, 55% by mass ethanol and 45% by mass water, 60% by mass ethanol and 40% by mass water, 65% by mass ethanol and 35% by mass water, 70% by mass ethanol and 30% by mass water, 75% by mass ethanol and 25% by mass water, 80% by mass ethanol and 20% by mass water, 85% by mass ethanol and 15% by mass water, 90% by mass ethanol and 10% by mass water, or 95% by mass ethanol and 5% by mass water, in each case based on the total amount of the volatile substances as the component (a).
  • the polymer having an ability to form a film containing a fiber deposit as the component (b) is generally a substance which can be dissolved in the volatile substance as the component (a).
  • the term “to dissolve” as mentioned herein means that the substance is in a dispersed state at 20°C., and that the dispersed state is visually uniform, and preferably visually transparent or translucent.
  • suitable polymers are used depending on the properties of the volatile substance as the component (a). Specifically, such polymers are roughly divided into water-soluble fiber-forming polymers and water-insoluble fiber-forming polymers.
  • the “water-soluble polymers” refer to those having the following property: 1 g of polymer is weighed in an environment of 1 atm and 23° C., then immersed in 10 g of ion-exchanged water, and after 24 hours, 0.5 g or more of the immersed polymer is dissolved in water. Meanwhile, in the present specification, the “water-insoluble polymers” refer to those having the following property: 1 g of polymer is weighed in an environment of 1 atm and 23° C., then immersed in 10 g of ion- exchanged water, and after 24 hours, 0.5 g or more of the immersed polymer is not dissolved in water.
  • water-soluble fiber-forming polymers examples include mucopolysaccharides, such as pullulan, hyaluronic acid, chondroitin sulfate, poly-y-glutamic acid, modified cornstarch, P-glucan, gluco-oligosaccharide, heparin, and keratosulfate; natural polymers, such as cellulose, pectin, xylan, lignin, glucomannan, galacturonic acid, psyllium seed gum, tamarind seed gum, gum arabic, tragacanth gum, soybean water-soluble polysaccharide, alginic acid, carrageenan, laminaran, agar (agarose), fucoidan, methylcellulose, hydroxypropyl cellulose, and hydroxypropyl methylcellulose; and synthetic polymers, such as partially-saponified polyvinyl alcohol (when not used in combination with a crosslinking agent), low-saponified polyvinyl alcohol, water
  • water-soluble polymers can be used singly or in combination of two or more.
  • these water-soluble polymers from the viewpoint of easy production of the film, it is preferable to use one or more selected from the group consisting of pullulan and synthetic polymers, such as partially-saponified polyvinyl alcohol, low-saponified polyvinyl alcohol, water-soluble nylon, polyvinyl pyrrolidone, and polyethylene oxide.
  • pullulan and synthetic polymers such as partially-saponified polyvinyl alcohol, low-saponified polyvinyl alcohol, water-soluble nylon, polyvinyl pyrrolidone, and polyethylene oxide.
  • polyethylene oxide is used as the water-soluble polymer, the number average molecular weight thereof is preferably 50,000 or more and 3,000,000 or less, and more preferably 100,000 or more and 2,500,000 or less.
  • examples of the water-insoluble fiber-forming polymers include completely- saponified polyvinyl alcohol insolubilizable after the formation of the film; partially-saponified polyvinyl alcohol crosslinkable used in combination with a crosslinking agent after the formation of the film; oxazoline-modified silicones, such as poly(N-propanoylethyleneimine) graft- dimethylsiloxane/Y-aminopropylmethylsiloxane copolymer; polyvinylacetal diethylaminoacetate; Zein (main component of com protein); polyester resins, such as polyester and polylactic acid (PLA); acrylic resins, such as polyacrylonitrile resin and polymethacrylic acid resin; polystyrene resins, polyvinyl butyral resins, polyethylene terephthalate resins, polybutylene terephthalate resins, polyurethane resins, polyamide resins, polyimide resins, and polyamideimide resins.
  • water-insoluble polymers can be used singly or in combination of two or more.
  • the content of the component (b) in the composition X is preferably 2% by mass or more, preferably 3% by mass or more, preferably 4% by mass or more, preferably 6% by mass or more, and even more preferably 9% by mass or more. Moreover, the content of the component (b) in the composition X is preferably 50% by mass or less, preferably 45% by mass or less, preferably 40% by mass or less, preferably 24% by mass or less, preferably 18% by mass or less, and even more preferably 15% by mass or less.
  • the content of the component (b) in the composition X is preferably 2% by mass or more and 50% by mass or less, preferably 4% by mass or more and 45% by mass or less, and even more preferably 6% by mass or more and 40% by mass or less.
  • the content of the component (b) in the composition Y is 3% by mass or more and 24% by mass or less, 6% by mass or more and 18% by mass or less, or 9% by mass or more and 15% by mass or less.
  • the content ratio of the component (a) and the component (b), ((a)/(b), mass/mass), in the composition X is preferably 0.5 or more and 40 or less, more preferably 1 or more and 30 or less, and even more preferably 1.3 or more and 25 or less, from the viewpoint that the component (a) can be sufficiently volatilized when an electrostatic spray method is carried out.
  • the content ratio of ethanol and the component (b), (ethanol/(b), mass/mass), in the composition X is preferably 0.5 or more and 40 or less, more preferably 1 or more and 30 or less, and even more preferably 1.3 or more and 25 or less, from the viewpoint that ethanol can be sufficiently volatilized when an electrostatic spray method is carried out.
  • the composition X may contain one or more glycols.
  • glycols include ethylene glycol, propylene glycol, butylene glycol, diethylene glycol, dipropylene glycol, and polypropylene glycol.
  • the content of glycol in the composition X is preferably 10% by mass or less, and more preferably 8% by mass or less.
  • the water content is preferably less than 50% by mass, more preferably 45% by mass or less, further more preferably 10% by mass or less, and even more preferably 5% by mass or less; and preferably 0.2% by mass or more, and more preferably 0.4% by mass or more, based on the total amount of the volatile substances as the component (a).
  • the composition X may contain a powder.
  • powders include color pigments, extender pigments, and organic powder.
  • the content of the powder in the composition X is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 1% by mass or less; the powder is preferably substantially not contained.
  • composition X may contain only the components (a) and (b) described above, or may contain other components in addition to the components (a) and (b).
  • other components include plasticizers, surfactants, oil agents (non-limiting examples of which include di(phytosteryl/octyldodecyl) lauroyl glutamate), polyols which are liquid at 20°C. other than those mentioned above, such as glycerol, UV protective agents, skin protectants, flavoring agents, repellents, antioxidants, stabilizers, antiseptics, antiperspirant, and various vitamins.
  • each of these agents is not limited to the intended use of each agent, and can be used for other applications depending on the purpose; for example, an antiperspirant can be used as a flavoring agent. Alternatively, as combined use with other applications, for example, they can be used as those having an effect as an antiperspirant and an effect as a flavoring agent.
  • the plasticizer may be present in an amount ranging from 0.01% to 10%, or from 0.1% to 9%, or from 0.5% to 8%, or from 1% to 7% by mass of the composition X. The amount can also range from 0.01%, or 0.1%, or 0.5%, or 1% to 7%, or 8%, or 9%, or 10% by mass of the composition X.
  • the composition X includes 6.8% by mass of the plasticizer.
  • the plasticizer is butylene glycol.
  • butylene glycol is 1,3 butylene glycol.
  • plasticizers include polyols, polyoxyalkylene glycols, glycerin monofatty acid esters, glycerin difatty acid esters, malic acid diesters, N-acyl amino acid esters, ethylhexyl methoxycinnamate, and alkyl benzoates.
  • the surfactant may be present in an amount ranging from 0.01% to 1%, or from 0.1% to 0.8%, or from 0.25% to 0.75% by mass of the composition X. The amount can also range from 0.01%, or 0.1%, or 0.25% to 0.75%, or 0.8%, or 1% by mass of the composition X.
  • the composition X includes 0.5% of the surfactant by mass.
  • the surfactant may be a cationic surfactant, which can enhance the conductivity of the composition X.
  • the surfactant can be a nonionic surfactant, such as polyoxyethylene hydrogenated castor oil. A nonionic surfactant, rather than enhancing conductivity, would enhance compatibility, and increased absorption, of the composition to the network of fibers.
  • Non-limiting examples of other additives can be found in US 20210038530.
  • Such additives include plasticizers, agents for enhancing conductivity of the polymer during fiber formation, and agents for enhancing aesthetic, feel, and sensory features of formed network of fibers when applied to the surface of skin.
  • the content ratio of the other components is preferably 0.1% by mass or more and 30% by mass or less, and more preferably 0.5% by mass or more and 20% by mass or less.
  • the composition X is directly electrostatically sprayed to the skin to form a film or coating containing a fiber deposit on the skin surface, either before or after the topical composition containing HCE is applied to the skin.
  • the composition X used has a viscosity at 25°C. of preferably 1 mPa s or more, more preferably 10 mPa s or more, and even more preferably 50 mPa s or more. Further, the viscosity at 25°C. is preferably 5,000 mPa s or less, more preferably 2,000 mPa s or less, and even more preferably 1,500 mPa-s or less. The viscosity of the composition X at 25°C.
  • composition X is preferably 1 mPa s or more and 5,000 mPa-s or less, more preferably 10 mPa-s or more and 2,000 mPa s or less, and even more preferably 50 mPa s or more and 1,500 mPa s or less.
  • Use of the composition X having a viscosity in these ranges facilitates forming a porous film containing a fiber deposit by an electrostatic spray method. The formation of a porous film containing a fiber deposit is advantageous from the viewpoint of masking the surface of the skin and promoting healing.
  • the viscosity of the composition X is measured at 25°C. using an E-type viscometer. Examples of the E-type viscometer suitable for use include an E-type viscometer manufactured by Tokyo Keiki Inc. The rotor suitable for that case is rotor No. 43.
  • the composition X is directly sprayed to the human skin by an electrostatic spray method.
  • the electrostatic spray method comprises a step of forming a film or coating by electrostatically spraying a spray composition to the skin using an electrostatic spray device in an electrostatic spraying process.
  • the electrostatic spray device is equipped with a container for containing the spray composition, a nozzle for discharging the spray composition, a supply unit for supplying the spray composition contained in the container to the nozzle, and a power supply for applying a voltage to the nozzle.
  • FIG. 1 shows a schematic diagram showing the structure of an electrostatic spray device suitably used in the present invention.
  • the electrostatic spray device 10 shown in FIG. 1 is equipped with a low-voltage power supply 11.
  • the low-voltage power supply 11 is capable of generating a voltage of at least 10 V to less than 20 V.
  • the low-voltage power supply 11 preferably comprises one or more batteries.
  • the use of a battery(s) as the low- voltage power supply 11 is advantageous in that they can be easily replaced if necessary.
  • an AC adapter or the like can also be used as the low-voltage power supply 11.
  • FIG. 2 shows a situation of electrostatic spraying on one's own skin.
  • the means (2) is a step of applying a sheet composed of a fiber deposit to the skin.
  • the sheet composed of a fiber deposit used in the means (2) is preferably one obtained by electrospinning or melt blow of the composition X comprising the components (a) and (b) on a substrate.
  • the electrospinning means can also be carried out in the same manner as in the electrostatic spray means described above, using either a resin solution or a resin melt as the spray composition.
  • the spray composition is a resin solution
  • the resin solution is discharged from the electrostatic spray device, volatile solvent in the resin solution evaporates, and the resin (which is a solute) solidifies to form a film containing a fiber deposit.
  • the spray composition is a resin melt
  • the spray composition generally contains a lesser amount of volatile solvent (even including no volatile solvent) than in the resin solution. In this case, the resin is melted at a temperature equal to or higher than the melting point, and the molten resin is discharged to form a film containing a fiber deposit.
  • the melt blow means can melt a resin at a temperature equal to or higher than the melting point, and discharge the molten resin while also discharging hot air around the discharge port to form a film containing a fiber deposit having a desired average fiber diameter, such as 0.01 to 7 pm.
  • Non-limiting examples of electrospinning process conditions for the resin solution method may be as follows: a voltage ranging from 7.5 kV to 70 kV (for instance 30 kV); a distance between an end tip of a nozzle and a collecting plate ranging from 50 mm to 400 mm (for instance 200 mm); a dispensing rate ranging from 0.5 mL/hour to 4 mL/hour (for instance 2 mL/hour); an ambient temperature ranging from 20°C. to 30°C. (for instance 24°C.); and a relative humidity ranging from 35% to 45% (for instance 40%).
  • the sheet composed of a fiber deposit may be in the shape of a patch, a pad, or a strip. Such a sheet may be a square, for instance measuring 3 cm x 3 cm, or may be circle with a diameter of, for instance, 5 cm.
  • a basis weight of the sheet may range from 3.75 g/m 2 to 6.0 g/m 2 , for instance 4.5 g/m 2 .
  • a thickness of the sheet may range from 10 pm to 20 pm.
  • the fibers in the fiber deposit of the sheet used in means (2) may be the same as the fibers formed by electrospraying in means (1).
  • the fibers in the fiber deposit of the sheet used in means (2) comprise a water-insoluble fiber-forming polymer.
  • the fibers comprise at least one member selected from the group consisting of a partially saponified polyvinyl alcohol, a low saponified polyvinyl alcohol, a full saponified polyvinyl alcohol, a polyvinyl butyral resin, a polyurethane resin, a polymethacrylate resin, an oxasoline denatured silicone, a polyvinyl acetal di ethyl ami noacetate, a polylactic acid, and an ethyl cellulose.
  • the fibers comprise a polyvinyl butyral resin.
  • the fibers further comprise a plasticizing agent and/or a processing aid.
  • the fibers further comprise a surfactant and/or a glycol.
  • the fibers in the fiber deposit of the sheet used in means (2), and the fibers formed by electrospraying in means (1) may have an average diameter ranging from 10 nm to 3000 nm, or from 100 nm to 200 nm.
  • the average diameter can range from 10 nm or 100 nm to 200 nm or 3000 nm.
  • each fiber has a diameter ranging from 10 nm to 3000 nm or from 100 nm to 200 nm.
  • each fiber has a diameter ranging from 10 nm or 100 nm to 200 nm or 3000 nm. Fiber diameter is measured by scanning electron microscopy (SEM) at a magnification of 10000X.
  • SEM scanning electron microscopy
  • composition Y comprising one or more selected from the group consisting of an oil agent and a polyol before or after the application of the composition X (in means (1)) or the application of the sheet (in means (2)) to the skin, from the viewpoint of imparting more excellent transparency to the film formed and improving durability (abrasion resistance, stretchability, etc.).
  • the composition Y may further contain an adhesive polymer, from the viewpoint of improving the durability of the film formed.
  • oils oil in a liquid state at 20°C.
  • solid oils oil in a solid state at 20°C.
  • the liquid oils in the present invention also include oils in a liquid state and oils in a flowable semi-solid state at 20°C.
  • the liquid oils include hydrocarbon oils, ester oils, higher alcohols, silicone oils, and fatty acids.
  • hydrocarbon oils, ester oils, and silicone oils are preferable. Further, one or more of these liquid oils can be used in combination.
  • liquid hydrocarbon oils examples include liquid paraffin, squalane, squalene, n- octane, n-heptane, cyclohexane, light isoparaffin, liquid isoparaffin, hydrogenated polyisobutene, polybutene, and polyisobutene.
  • liquid paraffin, light isoparaffin, liquid isoparaffin, squalane, squalene, n-octane, n-heptane, and cyclohexane are preferable; and liquid paraffin and squalane are more preferable.
  • the viscosity of hydrocarbon oils at 30°C. is preferably 1 mPa s or more, and more preferably 3 mPa-s or more.
  • the total content of isododecane, isohexadecane, and hydrogenated polyisobutene in the liquid agent is preferably 10% by mass or less, more preferably 5% by mass or less, even more preferably 1% by mass or less, and further more preferably 0.5% by mass or less, and they may not be contained.
  • the viscosity of ester oils and silicone oils at 30°C. is preferably 1 mPa s or more, and more preferably 3 mPa-s or more.
  • the viscosity herein is measured at 30°C. using a BM-type viscometer (manufactured by Tokimec Inc., measurement conditions: rotor No. 1, 60 rpm, 1 minute).
  • the total content of ether oils e.g., cetyl- 1,3 -dimethylbutyl ether, dicapryl ether, dilauryl ether, and diisostearyl ether
  • the total content of ether oils e.g., cetyl- 1,3 -dimethylbutyl ether, dicapryl ether, dilauryl ether, and diisostearyl ether
  • ester oils include esters containing linear or branched fatty acids and linear or branched alcohols or polyhydric alcohols. Specific examples thereof include isopropyl myristate, cetyl isooctanoate, isocetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, decyl oleate, octyldodecyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, ethylhexyl isononanoate, isononyl isononanoate, isotridecyl isononanoate, isostearyl isostearate, choleste
  • At least one is preferably selected from the group consisting of octyldodecyl myristate, myristyl myristate, isocetyl stearate, isononyl isononanoate, isocetyl isostearate, cetearyl isononanoate, diisobutyl adipate, di-2-etylhexyl sebacate, isopropyl myristate, isopropyl palmitate, diisostearyl malate, neopentylglycol dicaprate, (Ci2-Cis)alkyl benzoate, and caprylic/capric triglyceride; more preferably at least one selected from the group consisting of isopropyl myristate, isopropyl palmitate, diisostearyl malate, neopentyl
  • ester oils vegetable oils and animal oils containing the above ester oils can also be used.
  • examples thereof include olive oil, jojoba oil, macadamia nut oil, meadowfoam oil, castor oil, safflower oil, sunflower oil, avocado oil, canola oil, apricot oil, rice embryo oil, and rice bran oil.
  • higher alcohols examples include liquid higher alcohols having 12 to 20 carbon atoms, and higher alcohols containing a branched chain fatty acid as a constituent are preferable. Specific examples thereof include isostearyl alcohol, and oleyl alcohol.
  • the liquid silicone oil is, for example, linear silicone, cyclic silicone, or modified silicone.
  • examples thereof include dimethylpolysiloxane, dimethylcyclopolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, phenyl-modified silicone, and higher alcohol-modified organopolysiloxane.
  • an oil agent which is solid at 20°C. (solid oil) can also be used.
  • the oil agent solid at 20°C. is preferably one which exhibits solid properties at 20°C. and has a melting point of 40°C. or higher.
  • Examples of the oil agent solid at 20°C. include hydrocarbon wax, ester wax, parahydroxybenzoic acid esters, higher alcohols, linear fatty acid esters having 14 or more carbon atoms, triglycerides containing three linear fatty acids having 12 or more carbon atoms as constituents, and silicone wax.
  • Such waxes are not limited as long as they are used in ordinary cosmetics.
  • mineralbased waxes such as ozokerite and ceresin
  • petroleum-based waxes such as paraffin, microcrystalline wax, and petrolatum
  • synthetic hydrocarbon waxes such as Fischer-Tropsch wax and polyethylene wax
  • plant-based waxes such as carnauba wax, candelilla wax, rice wax, Japan wax, sunflower wax, and hydrogenated jojoba oil
  • animal -based waxes such as beeswax and whale wax
  • synthetic waxes such as silicone wax, fluorine-based wax, and synthetic beeswax
  • fatty acids higher alcohols, and the derivatives thereof.
  • parahydroxybenzoic acid esters examples include methyl parahydroxybenzoate, ethyl paraaminobenzoate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate, propyl parahydroxybenzoate, and benzyl parahydroxybenzoate.
  • examples of triglycerides containing three linear fatty acids having 12 or more carbon atoms as constituents include glyceryl trilaurate, glyceryl trimyristate, glyceryl tripalmitate, and glyceryl tribehenate.
  • fatty acid ester oils containing linear fatty acids having 14 or more carbon atoms as constituents examples include myristyl myristate.
  • the content of the oil agent in the composition Y is preferably 1% by mass or more and 20% by mass or less, more preferably 2% by mass or more and 18% by mass or less, and even more preferably 3% by mass or more and 16% by mass or less.
  • polyol used in the composition Y examples include alkylene glycols, such as ethylene glycol, propylene glycol, 1,3 -propanediol, and 1,3 -butanediol; polyalkylene glycols, such as diethylene glycol, dipropylene glycol, polyethylene glycol with a molecular weight of 1000 or less, and polypropylene glycol; and glycerols, such as glycerol, diglycerol, and triglycerol.
  • alkylene glycols such as ethylene glycol, propylene glycol, 1,3 -propanediol, and 1,3 -butanediol
  • polyalkylene glycols such as diethylene glycol, dipropylene glycol, polyethylene glycol with a molecular weight of 1000 or less, and polypropylene glycol
  • glycerols such as glycerol, diglycerol, and triglycerol.
  • the content of the polyol in the composition Y is preferably 1% by mass or more and 40% by mass or less, more preferably 1% by mass or more and 30% by mass or less, further more preferably 3% by mass or more and 25% by mass or less, even more preferably 5% by mass or more and 20% by mass or less, and further even more preferably 10% by mass or more and 20% by mass or less.
  • the composition Y may be a cosmetic composition comprising one or more of the following components (A), (B), (C), (D), (E) and (F):
  • the total amount of components (A) and (D), [(A)+(D)], is from 2.5 to 12% by mass;
  • the mass ratio (A)/[(A)+(D)], which is the mass ratio of component (A) to the total amount of components (A) and (D), [(A)+(D)], is from 0.2 to 0.7;
  • the molar ratio (B)/[(B)+(C)], which is the molar ratio of component (B) to the total amount of components (B) and (C), [(B)+(C)], is from 5 to 60 mol %;
  • the molar ratio [(B)+(C)]/(A), which is the molar ratio of the total amount of components (B) and (C), [(B)+(C)], to component (A), is from 10 to 80 mol %.
  • Such cosmetic compositions are described in US 9,433,567, incorporated herein by reference.
  • the composition may include at least one adhesive polymer.
  • the composition may include no adhesive polymer.
  • the adhesive polymer may contribute to the improvement of the abrasion resistance and stretchability of the film formed on the skin by electrostatic spraying.
  • the adhesive polymer those generally used as adhesives or pressuresensitive adhesives can be used. Examples thereof include rubber-based adhesive polymers, silicone-based adhesive polymers, acrylic-based adhesive polymers, and urethane-based adhesive polymers. One or more of these polymers can be used.
  • the adhesive polymer at least one selected from the group consisting of nonionic polymers, anionic polymers, cationic polymers, and amphoteric polymers can be used.
  • the adhesive polymer is preferably a polymer other than the polymer as the component (b).
  • the adhesive polymer to be selected has good adhesiveness, from the viewpoint of improving the abrasion resistance and stretchability of the film.
  • the adhesive polymer is preferably a polymer having a maximum tensile shear load of 1 N or more, more preferably 3 N or more, and even more preferably 5 N or more, measured with reference to JIS K6850. From the viewpoint of ensuring adhesiveness, a polymer having a maximum tensile shear load of 8 N or more is further more preferable.
  • the maximum tensile shear load is preferably 200 N or less, more preferably 150 N or less, and even more preferably 100 N or less.
  • rubber-based adhesive polymers silicone-based adhesive polymers, acrylic-based adhesive polymers, and urethane-based adhesive polymers; and it is preferable to use at least one selected from the group consisting of nonionic polymers, anionic polymers, cationic polymers, and amphoteric polymers.
  • the adhesiveness (maximum tensile shear load) of the polymer can be measured as follows. Twenty mg of a polymer solution (10% ethanol solution or saturated solution) is applied to one polycarbonate substrate (manufactured by Standard Test Piece, Carboglass Polish Clear, 10 cm> ⁇ 2.5 cm*2.0 mm) at the edge in the area of 1.25 cm*2.5 cm. This substrate is bonded together with another polycarbonate substrate, and dried for 12 hours or more. Tensilon UTC- 100W manufactured by Orientec Co., Ltd. is used to pull both ends of the polycarbonate substrates at a tensile speed of 5 ram/min, and the maximum tensile shear load is measured.
  • the content thereof is preferably 5% by mass or more and 20% by mass or less, and more preferably 6% by mass or more, from the viewpoint of the abrasion resistance and stretchability of the film.
  • the content of the adhesive polymer is more preferably 15% by mass or less, even more preferably 12% by mass or less, and further more preferably 10% by mass or less.
  • the content of the adhesive polymer is preferably 5% by mass or more and 15% by mass or less, more preferably 5% by mass or more and 12% by mass or less, and even more preferably 5% by mass or more and 10% by mass or less.
  • the step of applying the composition Y to the skin may be performed before or after the application of the composition X (in means (1)) or the application of the sheet (in means (2)) to the skin.
  • the means for applying the composition Y to the skin include a means for applying the composition Y to the skin with fingers or the like, a means for applying the composition Y to the skin using an applicator, and the like.
  • the composition X and the composition Y have different formulations.
  • the composition X to be subjected to electrospinning and the composition Y to be applied to the skin before or after that are separately formulated with different formulations. Even if the composition Y is electrostatically sprayed to form a film, a deposit containing the same fibers as the composition X is not formed.
  • the means (3) is a step of applying a composition Z comprising the following components (c), (d) and optionally (e):
  • oil agent and polyol as the component (c) used in the composition Z include the oil agents and polyols used in the composition Y described above.
  • examples of the oil agent contained in the composition Z include one or more selected from the group consisting of liquid oils (oils in a liquid state at 20°C.) and solid oils (oils in a solid state at 20°C.)
  • the content of the oil agent in the composition Z is preferably 1% by mass or more and 20% by mass or less, more preferably 2% by mass or more and 18% by mass or less, and even more preferably 3% by mass or more and 16% by mass or less.
  • ethylene glycol, propylene glycol, 1,3-butanediol, dipropylene glycol, polyethylene glycol with a molecular weight of 1000 or less, glycerol, and diglycerol are preferable; propylene glycol, 1,3 -butanediol, and glycerol are more preferable; and glycerols are even more preferable.
  • the content of the polyol in the composition Z is preferably 1% by mass or more and 40% by mass or less, more preferably 1% by mass or more and 30% by mass or less, even more preferably 3% by mass or more and 25% by mass or less, further more preferably 5% by mass or more and 20% by mass or less, and even further more preferably 10% by mass or more and 20% by mass or less.
  • the composition Z contains a volatile component, from the viewpoint of forming a fiber deposit on the skin when the composition Z is applied to the skin.
  • the volatile component used in the composition Z is preferably one or more selected from the group consisting of water, alcohols, volatile silicones, volatile hydrocarbons, and the like.
  • Examples of preferably used alcohols include monovalent chain aliphatic alcohols, monovalent cyclic aliphatic alcohols, and monovalent aromatic alcohols.
  • Examples of monovalent chain aliphatic alcohols include Ci-Ce alcohols
  • examples of monovalent cyclic alcohols include C4-C6 cyclic alcohols
  • examples of monovalent aromatic alcohols include benzyl alcohol, and phenylethyl alcohol. Specific examples thereof include ethanol, isopropyl alcohol, butyl alcohol, phenylethyl alcohol, n-propanol, and n-pentanol.
  • One or more of these alcohols can be used.
  • volatile silicone oils examples include dimethylpolysiloxane and cyclic silicone.
  • the content of the volatile component is preferably from 15 to 90% by mass in the composition Z, from the viewpoint of the coating properties of the composition Z and the uniformity of the film; more preferably 20% by mass or more, and even more preferably 30% by mass or more, from the viewpoint of usability when the composition Z is applied to the skin; and preferably 87% by mass or less, and more preferably 85% by mass or less, from the viewpoint of the formability of the fiber deposit after the composition Z is applied to the skin, and the durability of the film.
  • the fibers contained in the composition Z are (d) fibers having an average fiber diameter ranging from 0.01 to 7 pm and an aspect ratio (average fiber length/av erage fiber diameter) ranging from 10 to 1000.
  • the fibers contained in the composition Z of means (3) may be the same as the fibers formed by electrospraying in means (1).
  • the fibers contained in the composition Z of means (3) comprise a water-insoluble fiber-forming polymer.
  • the fibers comprise at least one member selected from the group consisting of a partially saponified polyvinyl alcohol, a low saponified polyvinyl alcohol, a full saponified polyvinyl alcohol, a polyvinyl butyral resin, a polyurethane resin, a polymethacrylate resin, an oxasoline denatured silicone, a polyvinyl acetal di ethyl ami noacetate, a polylactic acid, and an ethyl cellulose.
  • the fibers comprise a polyvinyl butyral resin.
  • the fibers further comprise a plasticizing agent and/or a processing aid.
  • the fibers further comprise a surfactant and/or a glycol.
  • the component (d) forms a fiber deposit in the formed film and imparts uniformity and close adhesiveness to the film. Whether the fibers form a deposit in the film can be confirmed by a scanning electron microscope or the like.
  • the term “deposit” refers to a state in which the fibers dispersed in the film have intersections with each other so as to have gaps, and a state in which the components contained in the composition can be retained in the gaps.
  • the average fiber diameter of the fibers used in the composition Z is 0.01 pm or more and 7 pm or less. Moreover, from the viewpoint of the adhesiveness and fitness of the film, the average fiber diameter of the fibers is preferably 0.05 pm or more, more preferably 0.1 pm or more, further more preferably 0.2 pm or more, and even more preferably 0.3 pm or more; and preferably 5 pm or less, more preferably 4 pm or less, and even more preferably 3 pm or less.
  • the fiber diameter can be measured, for example, by observing the fibers by scanning electron microscope observation at a magnification of from 2000 times or 5000 times, randomly selecting 100 fibers, except for defects (e.g., lumps of fibers and intersections of fibers), from the two-dimensional image, drawing a line orthogonal to the longitudinal direction of each fiber, and directly reading the fiber diameter.
  • the average fiber diameter was determined by calculating the arithmetic average of these measured values.
  • the fiber length as the average fiber length is preferably 20 pm or more and 500 pm or less, more preferably 30 pm or more, and even more preferably 40 pm or more; and more preferably 400 pm or less, further more preferably 250 pm or less, and even more preferably 200 pm or less.
  • the average fiber length can be measured, for example, by observing the fiber length by scanning electron microscope observation at a magnification ranging from 250 times or 750 times depending on the fiber length, randomly selecting 100 fibers, except for defects (e.g., lumps of fibers and intersections of fibers), from the two-dimensional image, drawing a line in the longitudinal direction of each fiber, and directly reading the fiber length. The average fiber length was determined by calculating the arithmetic average of these measured values.
  • the aspect ratio of the fibers is 10 or more and 1,000 or less, preferably 15 or more, and more preferably 20 or more; and more preferably 500 or less, further more preferably 400 or less, and even more preferably 300 or less.
  • the ratio of (average fiber diameter 2 )/average fiber content (pm 2 /% by mass) is preferably within the range from 0.005 to 7.
  • this value is preferably 0.02 or more, more preferably 0.03 or more, and even more preferably 0.05 or more. Further, from the viewpoint of sufficiently forming a fiber deposit in the film, this value is preferably 6 or less, more preferably 5 or less, even more preferably 4 or less, and further more preferably 3 or less.
  • This value i.e., the ratio of (average fiber diameter 2 )/average fiber content (pm 2 /% by mass), is an index of the cumulative length of the fibers contained in the composition Z, and means that the larger this numerical value, the shorter the cumulative length.
  • the fibers as the component (d) can be produced by grinding fibers obtained by treating fiber-forming polymers by various known spinning techniques.
  • the fiber-forming polymers mentioned herein are generally thermoplastic or solvent-soluble chain polymers.
  • the fiber-forming polymers it is preferable to use a water-insoluble polymer, in terms of maintaining the shape of the fibers in the composition Z.
  • an electrospinning method electric field spinning method is preferable in terms of obtaining fibers with a small fiber diameter.
  • the composition Z may contain surfactants, antiseptics, various powders, moisturizers other than polyols, water-soluble polymers, amino acids, dyes, and the like.
  • surfactants such as soaps, soaps, and the like.
  • composition Z may be applied to the skin either before or after the HCE is applied to the skin.
  • composition Z may contain HCE.
  • Horse Chestnut (Aesculus hippocastanum) seed extract historically has been used to treat joint pain, bladder and gastrointestinal problems, fever, leg cramps, and other conditions. More recently, it has been used to treat chronic venous insufficiency (CVI; poor blood flow in the veins of the legs, which may lead to leg pain, swelling, itchiness, and other symptoms), irritable bowel syndrome, male infertility, and other conditions.
  • CVI chronic venous insufficiency
  • CVI chronic venous insufficiency
  • irritable bowel syndrome male infertility, and other conditions.
  • Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum (the horse chestnut). Escin is the main active component in horse chestnut, and is responsible for most of its medicinal properties.
  • the main active compound of escin is P-escin, although the mixture also contains various other components including a-escin, protoescigenin, barringtogenol, cryptoescin and benzopyrones.
  • P-escin has the following chemical structure (CAS No. 8053-39-2):
  • the composition comprising HCE preferably contains at least 0.1% by mass, at least 0.2% by mass, at least 0.3% by mass, at least 0.4% by mass, or at least 0.5% by mass of HCE.
  • the composition comprising HCE preferably contains at most 5.0% by mass, at most 4.0% by mass, at most 3.0% by mass, at most 2.0% by mass, or at most 1.0% by mass of HCE.
  • these amounts refer to HCE having at least 90% by mass of active ingredients, such as 90% triterpene glycosides as escin (such as that provided as Venocin 90% by Sabinsa Corporation). Higher amounts of ingredient HCE in the composition are possible for HCE ingredients having lower fractions of active ingredients.
  • a composition comprising 0.5% by mass of HCE, where the HCE has 90% by mass of active ingredients corresponds to a composition comprising 2.25% by mass of HCE, where the HCE has 20% by mass of active ingredients.
  • the topical composition comprising HCE also comprises other, inactive, ingredients.
  • composition Y may include the oil agent, polyol, and/or other ingredients described above for composition Y.
  • topical composition comprising HCE may be a cosmetic composition comprising one or more of the following components (A), (B), (C), (D), (E) and (F):
  • the total amount of components (A) and (D), [(A)+(D)], is from 2.5 to 12% by mass;
  • the mass ratio (A)/[(A)+(D)], which is the mass ratio of component (A) to the total amount of components (A) and (D), [(A)+(D)], is from 0.2 to 0.7;
  • the molar ratio (B)/[(B)+(C)], which is the molar ratio of component (B) to the total amount of components (B) and (C), [(B)+(C)], is from 5 to 60 mol %;
  • the molar ratio [(B)+(C)]/(A), which is the molar ratio of the total amount of components (B) and (C), [(B)+(C)], to component (A), is from 10 to 80 mol %.
  • Such cosmetic compositions are described in US 9,433,567, incorporated herein by reference.
  • the topical composition comprising HCE also may comprise other, active, ingredients.
  • the composition comprising HCE also may comprise colloidal oatmeal, for instance as a skin protectant, or allantoin.
  • HCE in addition to HCE, or as an alternative to HCE, other materials may be used.
  • alternative materials to HCE include: rosmarinic acid, galanga extract, ximenynic acid, and oleanolic acid. Certain preferred embodiments are as follows:
  • Embodiment 1 A method of producing a coating on skin, the method comprising (i) and (ii):
  • Embodiment 3 The method of Embodiment 1, wherein the first composition comprises (a) and (b):
  • Embodiment 4 The method of Embodiment 3, wherein the polymer having a coating formability is a water-insoluble fiber-forming polymer.
  • Embodiment 5 The method of Embodiment 3, wherein the polymer having a coating formability comprises at least one member selected from the group consisting of a partially saponified polyvinyl alcohol, a low saponified polyvinyl alcohol, a full saponified polyvinyl alcohol, a polyvinyl butyral resin, a polyurethane resin, a polymethacrylate resin, an oxasoline denatured silicone, a polyvinyl acetal diethylaminoacetate, a polylactic acid, and an ethyl cellulose.
  • a partially saponified polyvinyl alcohol a partially saponified polyvinyl alcohol, a low saponified polyvinyl alcohol, a full saponified polyvinyl alcohol, a polyvinyl butyral resin, a polyurethane resin, a polymethacrylate resin, an oxasoline denatured silicone, a polyvinyl acetal diethylaminoacetate
  • Embodiment 8 The method of any one of Embodiments 1-6, wherein (i) is performed after (ii).
  • Embodiment 9 A method of producing a coating on skin, the method comprising (i) and (ii):
  • Embodiment 10 The method of Embodiment 9, wherein the fiber deposit has an average fiber diameter of from 0.01 pm to 7 pm obtained by electrospinning or melt blowing.
  • Embodiment 1 1 The method of Embodiment 9, wherein the fibers comprise a waterinsoluble fiber-forming polymer.
  • Embodiment 12 The method of Embodiment 9, wherein the fibers comprise at least one member selected from the group consisting of a partially saponified polyvinyl alcohol, a low saponified polyvinyl alcohol, a full saponified polyvinyl alcohol, a polyvinyl butyral resin, a polyurethane resin, a polymethacrylate resin, an oxasoline denatured silicone, a polyvinyl acetal diethylaminoacetate, a polylactic acid, and an ethyl cellulose.
  • the fibers comprise at least one member selected from the group consisting of a partially saponified polyvinyl alcohol, a low saponified polyvinyl alcohol, a full saponified polyvinyl alcohol, a polyvinyl butyral resin, a polyurethane resin, a polymethacrylate resin, an oxasoline denatured silicone, a polyvinyl acetal diethylaminoacetate,
  • Embodiment 13 The method of Embodiment 9, wherein the fibers comprise a polyvinyl butyral resin.
  • Embodiment 14 The method of any one of Embodiments 8-13, wherein the fibers further comprise a plasticizing agent and/or a processing aid.
  • Embodiment 16 The method of any one of Embodiments 8-15, wherein (i) is performed before (ii).
  • Embodiment 17 The method of any one of Embodiments 8-15, wherein (i) is performed after (ii).
  • Embodiment 18. A method of treating eczema, the method comprising (i) and (ii):
  • Embodiment 19 The method of Embodiment 18, which reduces perceived itching in the skin affected by eczema.
  • Embodiment 20 A method for treating skin, the method comprising (i) and (ii):
  • Embodiment 21 Use of a combination of the following compositions (i) and (ii), for treating eczema:
  • composition onto a surface of skin affected by eczema to form a coating composed of a deposit containing a fiber.
  • This ratio is set by internal evaluation for adhesiveness and permeability. It's contributing to hold the lotion on the skin and to create optimum moisture balance.
  • Table 2 shows the test formulations of polymer solutions for fiber sheet formation:
  • Table 2 Cell 1 had 10 panelists, cell 2 had 10 panelists, cell 3 had 15 panelists, and cell 4 had 15 panelists.
  • Each panelist was required to allow his or her skin to dry out (no application of other topical medications or body moisturizers) for 4 days prior to baseline (Day 0) measurement.
  • Each prototype was applied to lesions 2 times a day for 14 days. Measurements were taken on day 0, day 7, and day 14. Among the data obtained was perceived itching via a questionnaire. Results for the questionnaire are shown in FIG. 4.
  • each cell showed a decrease in itching in week 1 compared to baseline, and a further decrease in itching in week 2 compared to week 1.
  • a single asterisk indicates p ⁇ 0.05
  • a double asterisk indicates p ⁇ 0.01
  • a triple asterisk indicates p ⁇ 0.001 via a paired t-test.
  • Cell 4 combining 0.5% HCE plus a fiber sheet, showed the most significant decrease in itching over two weeks.
  • Percent ranges and point values are understood to have a +/-1 % tolerance.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un procédé de production d'un revêtement sur la peau, le procédé comprenant (i) et (ii) : (i) l'application sur la peau d'une feuille composée d'un dépôt de fibres, et (ii) l'application sur la peau d'une composition comprenant un extrait de graines de marronnier d'Inde, (i) pouvant être effectuée avant ou après (ii).
PCT/US2024/044589 2023-08-30 2024-08-30 Procédé de production d'un revêtement sur la peau Pending WO2025049851A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363535343P 2023-08-30 2023-08-30
US63/535,343 2023-08-30

Publications (1)

Publication Number Publication Date
WO2025049851A1 true WO2025049851A1 (fr) 2025-03-06

Family

ID=94820337

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/044589 Pending WO2025049851A1 (fr) 2023-08-30 2024-08-30 Procédé de production d'un revêtement sur la peau

Country Status (1)

Country Link
WO (1) WO2025049851A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3170916A (en) * 1961-02-23 1965-02-23 Chem Fab Tempelhof Preuss & Te Method of producing durable saponine containing extracts from horse chestnut and products obtained therefrom
US8841264B2 (en) * 2006-07-14 2014-09-23 Dsm Ip Assets B.V. Compositions
US11338308B2 (en) * 2018-08-09 2022-05-24 Kao Corporation Method for producing wearable coating
US11583487B2 (en) * 2018-08-09 2023-02-21 Kao Corporation Method for producing coating
US20230240948A1 (en) * 2020-08-14 2023-08-03 Kao Corporation Method for producing coating
EP4389107A1 (fr) * 2022-12-23 2024-06-26 Aero-Bw K. Domagala Sp. Jawna Procédé de préparation d'une composition cosmétique contenant un extrait de métabolite végétal et composition cosmétique contenant un extrait de métabolite végétal

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3170916A (en) * 1961-02-23 1965-02-23 Chem Fab Tempelhof Preuss & Te Method of producing durable saponine containing extracts from horse chestnut and products obtained therefrom
US8841264B2 (en) * 2006-07-14 2014-09-23 Dsm Ip Assets B.V. Compositions
US11338308B2 (en) * 2018-08-09 2022-05-24 Kao Corporation Method for producing wearable coating
US11583487B2 (en) * 2018-08-09 2023-02-21 Kao Corporation Method for producing coating
US20230240948A1 (en) * 2020-08-14 2023-08-03 Kao Corporation Method for producing coating
EP4389107A1 (fr) * 2022-12-23 2024-06-26 Aero-Bw K. Domagala Sp. Jawna Procédé de préparation d'une composition cosmétique contenant un extrait de métabolite végétal et composition cosmétique contenant un extrait de métabolite végétal

Similar Documents

Publication Publication Date Title
EP3366270B1 (fr) Procédé de fabrication de film
US11571371B2 (en) Method for manufacturing coating film by electrostatic spraying
US11523670B2 (en) Method for producing coating film by electrostatic spraying
JP2018537500A (ja) （ポリ）グリセロールの少なくとも２つの脂肪酸エステルを含む組成物、および化粧品におけるその使用
JP7216484B2 (ja) 紫外線防御被膜の製造方法
WO2018194131A1 (fr) Procédé de formation de pellicule de revêtement sur une surface de peau
JP7216485B2 (ja) 化粧被膜の製造方法
WO2025049851A1 (fr) Procédé de production d'un revêtement sur la peau
JP7227701B2 (ja) 紫外線防御被膜の製造方法
JP7337897B2 (ja) 美容方法
WO2023027151A1 (fr) Méthode de production de film
TR2023018562A2 (tr) Aloe vera jeli̇, dekspantenol, vi̇tami̇n e ve vi̇tami̇n c?yi̇ kombi̇ne halde i̇çeren nanoemülsi̇yon bazli hi̇drojel ve organojel formülasyonlari
JP2023177929A (ja) 被膜形成用組成物
TW202131904A (zh) 處理皮膚的方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24861107

Country of ref document: EP

Kind code of ref document: A1