WO2025044730A1 - Split double-chamber balanced air pressure liquid medicine transfer device - Google Patents

Abstract

A split double-chamber balanced air pressure liquid medicine transfer device, comprising an assembly I and an assembly II, wherein the assembly I comprises a first syringe (1), a first needle hub (2), and a dispensing needle assembly (3); and the assembly II comprises a second syringe (4), a second needle hub (5), and a puncture needle (6) fixedly connected to the second needle hub (5). When the assembly I and the assembly II are fixedly connected, the puncture needle (6) of the assembly II pierces a sealing plug (25) in a vent (24) of the assembly I to be in communication with a second channel (22) in the first needle hub (2). The liquid medicine transfer device can be conveniently applied to a push injection device for quantitative liquid medicine transfer while retaining the characteristics of airtightness and air pressure balance.

Description

A split double-chamber pressure-balanced liquid medicine transfer device

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to a Chinese patent application filed on August 31, 2023, with application number 202311115785.2 and titled “A Split Dual-Chamber Air Pressure Balanced Drug Liquid Transfer Device”.

Technical Field

The invention relates to the field of medical medicine dispensing and liquid transfer devices, in particular to a split double-chamber air pressure balanced medicine liquid transfer device.

Background Art

Dangerous drugs, such as chemotherapy drugs, are extremely harmful to the health of medical staff who prepare and transport such drugs for a long time. Some medical institutions have built various clean rooms, biological cabinets and other facilities to reduce the risk of drug leakage. The investment is huge, but the actual promotion and application effect is not good.

The Chinese patent with announcement number CN115607444B (CN202211220305.4) discloses a closed liquid medicine transfer device and liquid medicine transfer system with dual-chamber circulation. The dispensing device is equipped with a dual-chamber syringe, one chamber for infusing liquid and the other chamber for balancing air pressure, which effectively ensures the airtightness of the dispensing process and reduces the risk of leakage.

Another application of a drug liquid transfer device (i.e., a dispenser) is to serve as a drug supply source in a drug supply device to achieve quantitative drug supply. Generally speaking, after the drug is prepared, this type of dispensing device needs to be installed on a push injection device that can control the infusion volume/infusion speed (such as Medfusion's WZS-50F6 push injection device, and MEDCAPTAIN's SYS-52 push injection device). The push injection device can fix the syringe of the dispenser and push the piston rod to move at a preset speed, thereby achieving quantitative infusion. If the dual-chamber syringe is directly installed on the push injection device, the two piston rods will be pushed at the same time, making the push injection device unable to work, or occupying space and affecting the normal operation of other accessories.

Summary of the invention

In view of the problem that the new type of medicine dispenser cannot be used in the existing push injection equipment, the purpose of the present invention is to provide a split double-chamber pressure-balanced medicine liquid transfer device. The further improved medicine liquid transfer device can be conveniently used in the push injection equipment to transfer a quantitative amount of medicine liquid while retaining the characteristics of airtightness and pressure balance.

In order to achieve the above object, the present invention adopts the following technical solution.

A split double-chamber pressure-balanced liquid medicine transfer device comprises a component I and a component II, wherein: component I comprises a first syringe, a first needle seat and a dispensing needle assembly, wherein the first needle seat is connected and fixed to the first syringe through a joint on the first syringe, and the dispensing needle assembly is fixedly connected to the first needle seat; the first needle seat is provided with a first channel and a second channel inside, an air window is provided on the side, and a cavity for being connected and fixed to the joint on the first syringe is provided at the end; the end of the first channel is connected to the cavity, and the end of the second channel is connected to the air window; a sealing plug is provided in the air window; the dispensing needle assembly comprises an infusion channel and an exhaust channel, wherein the infusion channel is connected to the first channel, and the exhaust channel is connected to the second channel; component II comprises a second syringe, a second needle seat and a puncture needle fixedly connected to the second needle seat; when components I and II are fixedly connected, the puncture needle of component II pierces the sealing plug in the air window of component I to achieve communication with the second channel in the first needle seat; when components I and II are separated, the sealing plug in the air window makes the air window in a sealed state.

In the present invention, unless otherwise specified, when describing the component structure, the front end refers to the end to which the needle tip of the dispensing needle and/or puncture needle points, and the rear end (or tip) refers to the other end opposite thereto.

The structure of the syringe is easy to know and determine for those skilled in the art, and generally includes a syringe barrel and a piston rod that can slide back and forth along the inner cavity in the syringe barrel. Specifically, the first syringe includes a first syringe barrel and a first piston rod that can slide back and forth along the inner cavity in the first syringe barrel; the second syringe includes a second syringe barrel and a second piston rod that can slide back and forth along the inner cavity in the second syringe barrel.

Preferably, when the components I and II are fixedly connected, the first syringe and the second syringe are arranged side by side and in the same direction. Preferably, a snap-fit structure is provided on the outer wall of at least one of the first and second syringes, so that the first and second syringes can be detachably fixed to each other when they are arranged side by side and in the same direction. More preferably, at least one of the first and second syringes is provided with a support portion on the barrel wall, and the end structure of the support portion matches the outer side wall of the opposite syringe, so that the first and second syringes can support each other through the support portion when they are arranged side by side and in the same direction.

In the split double-chamber pressure-balanced liquid medicine transfer device of the present invention, component I includes a first syringe, a first needle seat and a dispensing needle assembly.

Inside the first needle seat, the end of the second channel is connected to the air window. When the puncture needle of component II pierces the sealing plug in the air window of component I, the second channel is connected to the second syringe via the puncture needle tube; when components I and II are separated, the sealing plug in the air window can keep the air window in a sealed state and isolate it from the outside world.

Preferably, a stop-go module for controlling the connection or disconnection of the second channel is provided in the second channel of the first needle seat, so as to further ensure the sealing of the second channel relative to the outside. As an embodiment, the stop-go module is a rotatable stop-go valve, and a through hole is provided in the valve; the stop-go valve can be rotated to make the through hole and the second channel aligned or misaligned, so as to conveniently realize the connection or disconnection of the channels on both sides. As another embodiment, the stop-go module is a control valve, and the control valve includes a slider, and a slide groove which is provided through the first needle seat and passes through the second channel radially, and the slider is slidably provided in the slide groove, and a through hole is provided in the slider; when the slider slides to a preset position, the two ends of the through hole are respectively connected to the second channel, and when the slider slides out of the preset position, the outer side surface of the slider disconnects the second channel.

As a preferred embodiment, the first needle seat is radially provided with a protrusion on one side close to the second channel, and the air window is provided at the end of the protrusion. Further preferably, the length of the protrusion exceeds the radius of the first injection cylinder.

The sealing plug is made of an elastic material, preferably any one of rubber, silicone, and synthetic rubber. Applicable elastic materials should comply with relevant standards for medical materials, which is easy to know and determine for those skilled in the art.

The medication dispensing needle assembly comprises an infusion channel and an exhaust channel, wherein the infusion channel is communicated with the first channel, and the exhaust channel is communicated with the second channel.

As an embodiment, the dispensing needle assembly is composed of a first needle tube and a second needle tube which are arranged in parallel and fixedly connected to the first needle seat in a rear end embedded manner. The inner cavity of the first needle tube constitutes an infusion channel, and the rear port is connected to the first channel; the inner cavity of the second needle tube constitutes an exhaust channel, and the rear port is connected to the second channel. Particularly preferably, the first needle tube, the first channel and the first syringe are arranged in a coaxial manner.

As another embodiment, the dispensing needle assembly is a double-layer columnar structure, having an inner column channel and a side ring channel, wherein one of the channels is used as an infusion channel and the other channel is used as an exhaust channel. Preferably, the dispensing needle assembly is composed of an inner needle tube and an outer needle tube, the inner needle tube is inserted into the outer needle tube, and both ends extend outside the outer needle tube. At this time, the inner column channel is composed of the inner cavity of the inner needle tube, and the side ring channel is composed of the cavity between the outer needle tube and the inner needle tube. The inner needle tube and the outer needle tube can be independent of each other, or they can be integrally formed and fixedly connected to each other. When the latter type is selected, it is preferred that the front end of the outer needle tube is fixedly connected to the front end side wall of the inner needle tube in a closed manner. Further preferably, the front end of the inner needle tube is set as an oblique opening, or the front end of the inner needle tube is a pointed end and is provided with a side opening; the front end side wall of the outer needle tube is provided with a side opening. Such a design of the opening is not only conducive to the dispensing needle piercing the container, but also can reduce the interference between the inner column channel and the side ring channel. As a specific embodiment, the double-layer columnar dispensing needle assembly, the first channel and the first syringe are coaxially arranged, the inner column channel formed by the inner cavity of the inner needle tube serves as an infusion channel, and the side ring channel formed by the cavity between the outer needle tube and the inner needle tube serves as an exhaust channel. As another specific embodiment, in the double-layer columnar dispensing needle assembly, the inner column channel formed by the inner cavity of the inner needle tube serves as an exhaust channel, and the side ring channel formed by the cavity between the outer needle tube and the inner needle tube serves as an infusion channel.

Preferably, component I also includes a needle sealing component, which includes a first sleeve, a first sealing member and a first elastic member arranged in a coaxial manner with the first needle seat; wherein: the first sleeve is a hollow cylindrical structure with front and rear openings, and is axially movably sleeved on the front end of the first needle seat; the first sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the first sleeve; a hole for the needle tube to pass through is provided in the first sealing member, and the inner diameter of the hole is smaller than the outer diameter of the needle tube; the first elastic member is arranged between the first sealing member and the first needle seat, and relies on the needle seat to provide the first sealing member at the front end with a hole; the first elastic member is provided with a hole; the first sealing ... Provide axial elastic support; in the non-pressurized state, the first elastic member stretches axially, the first sleeve shields the needle tube inside the sleeve, and under the elastic force of the elastic material, the first sealing member tightly wraps the front end of the needle tube, and seals the front end channel openings of the infusion channel and the exhaust channel; in the pressurized state, the first elastic member is axially compressed, and the front end of the needle tube including the front end channel openings of the infusion channel and the exhaust channel can pass through the first sleeve through the channel of the first sealing member.

The needle seal assembly can not only play a puncture-proof function, but also ensure that the preparation and transfer process of the liquid medicine is in a fully closed state, avoiding the risk of liquid medicine leaking from the front channel. Components with similar structures and functions have been reported in the applicant's prior patents, such as CN115607444B, which is fully introduced here.

As a preferred embodiment of the present invention, the needle sealing assembly includes a coaxially arranged first sleeve, a first sealing member, a first elastic member and an inner sleeve, wherein: the front end of the first sleeve has a smaller inner diameter, forming a composite cylindrical structure consisting of a first barrel section with a smaller inner diameter and a second barrel section with a larger inner diameter; the first sealing member is designed as a structure with an inverted T-shaped cross-section, the front diameter corresponds to the inner diameter of the first barrel section, and the rear diameter corresponds to the inner diameter of the second barrel section, so that the first sealing member can fill at least part of the second barrel section while completely filling the inner cavity of the first barrel section; the inner diameter of the inner sleeve corresponds to the outer diameter of the first needle seat, the outer diameter of the inner sleeve corresponds to the inner diameter of the second barrel section of the first sleeve, its front end face is closed and a through hole for the needle tube to pass through is provided on the end face; the inner sleeve is fixedly connected to the second barrel section of the first sleeve, and the front end face abuts against the rear end face of the first sealing member; the first elastic member is arranged in the inner sleeve, and the two ends abut against the front end inner surface of the inner sleeve and the front end face of the first needle seat respectively.

By improving the structure of the first sleeve and the first sealing member and adding an inner sleeve, the first sealing member is limited and fixed, and the front and rear ends of the first elastic member are both in contact with the hard material, so that the overall structure and performance are more stable. Further preferably, the outer wall of the inner sleeve is provided with a buckle, and the second barrel section of the first sleeve is provided with a corresponding clamping hole, and when the inner sleeve is inserted into the first sleeve, the fixed connection between the first sleeve and the inner sleeve is achieved through the cooperation of the buckle and the clamping hole. Preferably, the rear port of the inner sleeve is provided with an annular boss in a radially outward manner, and when the front end face of the inner sleeve is in contact with the rear end face of the first sealing member, the annular boss at the rear end is exposed to the first sleeve and is in contact with the rear end of the first sleeve.

It is easy to understand that during the use of the liquid medicine transfer device of the present invention, although the needle seal assembly will move axially with the expansion and contraction of the first elastic member, it always remains connected to the first needle seat. As a preferred embodiment, a buckle structure is provided on the front inner surface of the inner sleeve and the front end surface of the first needle seat, thereby achieving a fixed connection with the first elastic member. As another preferred embodiment, the side of the first needle seat is provided with an L-shaped groove composed of an axial groove and a transverse groove (perpendicular to the axial groove), and a slide is provided radially inwardly at the rear end of the inner sleeve, and the slide is embedded in the L-shaped groove and can slide along the groove. Through the position design of the slide and the L-shaped groove, the range of motion of the needle seal assembly relative to the first needle seat can be flexibly adjusted and limited. As the slide slides backward along the axial groove, the first elastic member is compressed and the needle tube passes through the first sealing member. When the set degree is reached, the slide is rotated along the transverse groove to limit the axial movement of the needle seal assembly, thereby achieving the effect of limiting and fixing.

The first sealing member is made of an elastic material, preferably any one of rubber, silicone, and synthetic rubber. Applicable elastic materials should comply with relevant standards for medical materials, which is easy for those skilled in the art to know and determine. As a preferred embodiment, the front end surface of the first sealing member protrudes beyond the front end surface of the first sleeve, so that when preparing and transferring liquid medicine, the sealing member made of the elastic material can fit the glue port of the container, thereby playing a role in better sealing the container opening.

The first elastic member can be an elastic folded tube, a spring, etc., preferably a spring.

It is easy to understand that, for the purpose of achieving better connection with infusion tubes, medicine bottles, push injection devices, etc., the front end of the first sleeve is preferably provided with a fixed connection structure (such as a rotating buckle structure, etc.) adapted to the pipetting connector, so as to facilitate fixed connection with the connector. The pipetting connector is easy to understand for those skilled in the art. There are a large number of reports of similar structures in the prior art. Its function is mainly to achieve auxiliary fixed connection between the drug liquid transfer device and the infusion tube interface, the mouth of the medicine bottle or the liquid inlet of other equipment; preferably, the pipetting connector is provided with a sealing member (such as a rubber plug) that can be pierced by a needle tube at one end of the corresponding drug liquid transfer device, so as to better play the sealing function during the infusion or drug liquid transfer process.

Component II includes a second syringe, a second needle holder, and a puncture needle fixedly connected to the second needle holder. When components I and II are fixedly connected, the puncture needle of component II pierces the sealing plug in the air window of component I and pierces the second needle holder in the first needle holder. Channels are connected.

It is easy to understand that the structural arrangement of the second needle seat and the puncture needle in component II should correspond to the structural arrangement of the air window in component I. Preferably, when the first needle seat is radially provided with a protrusion on one side close to the second channel, and the air window is provided at the end of the protrusion, the second needle seat and the puncture needle in component II are arranged perpendicular to the second syringe, and when the first syringe and the second syringe are fixedly connected in a side-by-side and unidirectional manner, the puncture needle transversely pierces the sealing plug to communicate with the second channel in the first needle seat.

In order to achieve better system sealing, preferably, component II also includes a puncture needle sealing component, which includes a second sleeve, a second sealing member and a second elastic member coaxially arranged with the puncture needle; wherein the second sleeve is a hollow cylindrical structure with an open front end and a rear end fixedly connected to the second needle seat; the second sealing member is made of elastic material and fixedly arranged in the front end cylinder of the second sleeve; a channel for the puncture needle to pass through is provided in the second sealing member, and the inner diameter of the channel is smaller than the outer diameter of the puncture needle; the second elastic member is arranged between the second sealing member and the second needle seat, and relying on the needle seat, the second elastic member provides axial elastic support for the second sealing member at the front end; in a non-pressurized state, the second elastic member extends axially, the second sleeve shields the puncture needle inside the sleeve, and under the elastic force of the elastic material, the second sealing member tightly wraps the front end of the puncture needle and closes the puncture needle opening inside; in a compressed state, the second sealing member slides toward the rear end, the second elastic member is axially compressed, and the front end of the puncture needle passes out of the second sealing member.

Further preferably, the puncture needle sealing assembly also includes a sliding sleeve coaxially arranged with the puncture needle. The sliding sleeve is a hollow cylindrical structure with front and rear openings, which is arranged in the second sleeve, and its outer diameter is adapted to the inner diameter of the second sleeve, and can slide forward and backward along the axial direction in the second sleeve, and the second sealing member is filled in the sliding sleeve. More preferably, the sliding sleeve is designed as a composite cylindrical structure consisting of a front barrel section with a larger inner diameter and a rear barrel section with a smaller inner diameter; accordingly, the second sealing member is designed as a structure with a T-shaped cross section, so that the second sealing member can completely fill the inner cavity of the sliding sleeve.

In order to prevent the second sealing member or the sliding sleeve filled with the second sealing member from moving outside the second sleeve, a limiting structure, such as a radially inward boss, is preferably provided at the front end of the second sleeve.

The second sealing member is made of an elastic material, preferably any one of rubber, silicone, and synthetic rubber. Applicable elastic materials should comply with relevant standards for medical materials, which is easy to know and determine for those skilled in the art. The second elastic member can be an elastic folding tube, a spring, etc., preferably a spring.

As a preferred embodiment of the liquid medicine transfer device of the present invention, the first needle seat in component I is radially provided with a protrusion on one side close to the second channel, and the air window is provided at the end of the protrusion; the second needle seat, the puncture needle and the puncture needle sealing assembly in component II are arranged in a manner perpendicular to the second syringe; when the first syringe and the second syringe are fixedly connected in a side-by-side and unidirectional manner, the air window provided with a sealing plug is inserted into the second sleeve and pushes the second sealing member or the sliding sleeve filled with the second sealing member to slide to the rear end, the second elastic member is axially compressed, and the front end of the puncture needle passes through the second sealing member and pierces the sealing plug to communicate with the second channel in the first needle seat. Further preferably, a fixed buckle structure is provided at the front end of the second sleeve, and a fixed buckle groove cooperating with the fixed buckle structure is provided on the protrusion of the first needle seat; when components I and II are fixedly connected, the fixed buckle structure and the fixed buckle groove are fixed to each other.

The liquid medicine transfer device of the present invention has the characteristics of double-chamber internal circulation. After the components I and II are fixed and connected in a closed manner, the infusion channel, the first channel, the cavity of the first needle seat and the first syringe are connected in sequence from front to back to form a closed passage I; the exhaust channel, the second channel, the puncture needle tube and the second syringe are connected in sequence from front to back to form a closed passage II. The closed passages I and II are independent of each other. During the preparation and transfer of the liquid medicine, the closed passage I is used to transfer the liquid medicine, and the closed passage II plays the role of transmitting gas and balancing air pressure. The liquid medicine transfer device can be used for the purpose of preparing mixed medicaments, transporting the prepared liquid medicine to an infusion bottle, an indwelling needle or a push injection device, etc. On the basis of fully understanding the structure of the liquid medicine transfer device of the present invention, it is easy for a person skilled in the art to determine how to use it to prepare and transfer the liquid medicine. For example, the applicant's prior patent CN115607444B can be referred to, which is introduced in its entirety.

Correspondingly, the present invention also relates to the application of the drug solution transfer device in quantitative infusion; and a quantitative infusion device comprising the drug solution transfer device.

It is easy to understand that, similar to the closed liquid medicine transfer device with double chamber circulation in CN115607444B, the liquid medicine transfer device of the present invention also has the following excellent effects: (1) the structure is exquisitely designed, and each component is convenient for mass production and The assembled components do not need to use relatively complex components and do not require the use of specific equipment. (2) The product has stable structure and performance, low cost but high yield, and is easy to use. (3) During the drug preparation and transfer process, the internal and external air pressures of the drug liquid transfer system are completely balanced. (4) It can achieve fully enclosed drug preparation and transfer, minimize the risk of drug leakage, and the sealing effect is excellent.

Furthermore, the present invention can also solve the problem that the new dual-chamber dispenser cannot be used with the existing push injection device. The biggest improvement is that the drug liquid transferor of the present invention is designed to be split. After the user prepares the drug liquid (the drug liquid is located in the first syringe), the user can easily separate component I and component II. At this time, the sealing plug re-seals the second channel, and component I can be very conveniently installed on the push injection device to transfer a quantitative amount of drug liquid.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a schematic cross-sectional view of the liquid medicine transfer device of Example 1 in a split state;

FIG2 is a schematic cross-sectional view of the drug liquid transfer device of Example 1 in an assembled state;

FIG3 is a schematic cross-sectional view of the drug liquid transfer device of Example 2 in an assembled state;

FIG4 is a schematic diagram of the use state of component I in the drug liquid transfer device of Example 2 connected to a chemotherapy pump;

FIG5 is a schematic cross-sectional view of the drug liquid transfer device of Example 3 in an assembled state;

Figure 6a is a physical picture of the sample in the assembled state;

Figure 6b is a physical picture of the sample in a split state;

FIG6c is a physical picture of samples equipped with various types of connectors;

FIG7 is a schematic diagram of the use status of component I in the liquid medicine transfer device of Example 3 on a single-channel quantitative injection device;

FIG8 is a schematic cross-sectional view of the drug liquid transfer device of Example 4 in a split state.

Figure numerals: first syringe 1, first syringe 11, first piston rod 12, joint 13, first needle seat 2, first channel 21, second channel 22, protrusion 23, air window 24, sealing plug 25, stop valve 26, fixed card slot 27, cavity 28, dispensing needle assembly 3, first needle tube 31, second needle tube 32, second syringe 4, second syringe 41, second piston rod 42, buckle structure 43, support portion 44, second needle seat 5, puncture needle 6, puncture needle sealing assembly 7, second sleeve 71, sliding sleeve 72, second sealing member 73, second elastic member 74, fixed buckle structure 75, needle sealing assembly 8, first sleeve 81, first sealing member 82, inner sleeve 83, first elastic member 84, pipetting connector 9, chemotherapy pump 10, capsule 101.

DETAILED DESCRIPTION

In order to better illustrate the purpose, technical solutions and advantages of the present invention, the specific implementation of the present invention is further described in detail below in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

Example 1

As shown in Fig. 1, a split double-chamber pressure-balanced liquid medicine transfer device of the present invention comprises a component I and a component II. The liquid medicine transfer device is in a split state, and components I and II are not fixedly connected.

Component I consists of a first syringe 1, a first needle seat 2 and a dispensing needle assembly 3.

The first syringe 1 comprises a first syringe barrel 11 , a first piston rod 12 which can slide forward and backward along an inner cavity in the first syringe barrel 11 , and a joint 13 arranged at the front end.

The first needle seat 2 is provided with a first channel 21 and a second channel 22 inside, and a protrusion 23 is radially provided on one side close to the second channel 22, the length of the protrusion 23 exceeds the radius of the first syringe 11, and an air window 24 is provided at the end of the protrusion 23. A cavity 28 for connecting and fixing with the connector 13 on the first syringe 1 is provided at the end of the first needle seat 2. The end of the first channel 21 is connected to the cavity 28, and the end of the second channel 22 is connected to the air window 24. A sealing plug 25 made of elastic medical silicone is fixedly provided in the air window 24 in an interference fit manner, and the sealing plug 25 makes the air window 24 in a sealed state and isolated from the outside.

The first needle seat 2 is connected and fixed to the first syringe 1 by inserting the connector 13 on the first syringe 1 into the cavity 28 at the end of the first needle seat 2 .

The dispensing needle assembly 3 is composed of a first needle tube 31 and a second needle tube 32 which are arranged in parallel and fixedly connected to the first needle seat 2 in a manner of embedding at the rear end. The inner cavity of the first needle tube 31 constitutes an infusion channel, and the rear end is connected to the first channel 21; the inner cavity of the second needle tube 32 constitutes an exhaust channel, and the rear end is connected to the second channel 22. The first needle tube 31, the first channel 21 and the first syringe 1 are arranged in a coaxial manner.

Component II includes a second syringe 4 , a second needle seat 5 , a puncture needle 6 fixedly connected to the second needle seat 5 , and a puncture needle sealing component 7 .

The second syringe 4 includes a second syringe 41 of the same size as the first syringe 11, and a second piston rod 42 that can slide forward and backward along the inner cavity in the second syringe 41. A support portion 44 is provided on the wall of the second syringe 41, and the end structure of the support portion 44 matches the outer wall of the first syringe 11, so that the first syringe 11 and the second syringe 41 can support each other through the support portion 44 when they are arranged side by side and in the same direction, so as to achieve a better fixing effect. A snap-fit structure 43 is provided on the outer wall of the end of the second syringe 41, so that the first syringe 11 and the second syringe 41 can be detachably fixed to each other when they are arranged side by side and in the same direction.

The structural arrangement of the second needle seat 5 and the puncture needle 6 corresponds to the structural arrangement of the air window 24 in the assembly 1. Specifically, the second needle seat 5 and the puncture needle 6 are arranged in a manner perpendicular to the second syringe 41, and when the first syringe 11 and the second syringe 41 are fixedly connected in a side-by-side and unidirectional manner, the puncture needle 6 can transversely pierce the sealing plug 25 and communicate with the second channel 22 in the first needle seat 2.

The puncture needle sealing assembly 7 comprises a second sleeve 71 , a sliding sleeve 72 , a second sealing member 73 and a second elastic member 74 which are coaxially arranged with the puncture needle 6 .

The second sleeve 71 is a hollow cylindrical structure with an open front end and a rear end fixedly connected to the second needle seat 5 .

The sliding sleeve 72 is a hollow cylindrical structure with front and rear openings, and is designed as a composite cylindrical structure consisting of a front cylindrical section with a larger inner diameter and a rear cylindrical section with a smaller inner diameter. The sliding sleeve 72 is arranged in the second sleeve 71, and its outer diameter is adapted to the inner diameter of the second sleeve 71, and can slide forward and backward in the second sleeve 71 along the axial direction.

The second sealing member 73 is made of elastic medical grade silicone and is designed to be a T-shaped structure in cross section, completely filling the inner cavity of the sliding sleeve 72. The second sealing member 73 is provided with a hole for the puncture needle 6 to pass through, and the inner diameter of the hole is smaller than the outer diameter of the puncture needle 6.

The second elastic member 74 is a spring, which is disposed between the sliding sleeve 72 and the second needle seat 5. Relying on the needle seat 5, the second elastic member 74 provides axial elastic support for the front end sliding sleeve 72. As shown in FIG1 , in a non-pressurized state, the second elastic member 74 is axially extended, the second sleeve 71 shields the puncture needle 6 inside the sleeve, and under the elastic force of the elastic material, the second sealing member 73 tightly wraps the front end of the puncture needle 6 to seal the puncture needle opening inside.

In order to prevent the sliding sleeve 72 filled with the second sealing member 73 from moving outside the second sleeve 71, a radially inward boss is provided at the front end of the second sleeve 71 to achieve the purpose of limiting. At the same time, a fixed buckle structure 75 is provided at the front end of the second sleeve 71, and the fixed buckle structure 75 is adapted to the fixed buckle groove 27 provided on the raised portion 23 of the first needle seat 2. When the components I and II are fixedly connected, the fixed buckle structure 75 and the fixed buckle groove 27 are connected and fixed to each other.

FIG2 shows the liquid medicine transfer device in a state where components I and II are fixedly connected. The first syringe 11 and the second syringe 41 are fixedly connected in a side-by-side and unidirectional manner, the air window 24 with the sealing plug 25 is inserted into the second sleeve 71 and pushes the sliding sleeve 72 filled with the second sealing member 73 to slide to the rear end, the second elastic member 74 is axially compressed, and the front end of the puncture needle 6 passes through the second sealing member 73 and pierces the sealing plug 25, and communicates with the second channel 22 in the first needle seat 2. At the same time, the fixed buckle structure 75 and the fixed card slot 27 are connected and fixed to each other.

As shown in FIG2 , after components I and II are fixed and connected in a sealed manner, the infusion channel, the first channel 21, the cavity 28 of the first needle seat 2 and the first syringe 11 are connected in sequence from front to back to form a closed passage I; the exhaust channel, the second channel 22, the puncture needle tube and the second syringe 41 are connected in sequence from front to back to form a closed passage II. The closed passages I and II are independent of each other. During the preparation and transfer of the liquid medicine, the closed passage I is used to transfer the liquid medicine, and the closed passage II plays the role of transferring gas and balancing air pressure.

Example 2

FIG3 shows another type of split double-chamber pressure-balanced liquid medicine transfer device of the present invention. Compared with the liquid medicine transfer device of Example 1, the main difference is that component I also includes a needle sealing component 8.

The needle sealing assembly 8 comprises a first sleeve 81 , a first sealing member 82 , an inner sleeve 83 and a first elastic member 84 which are arranged coaxially with the first needle seat 2 .

The front end of the first sleeve 81 has a smaller inner diameter, forming a composite cylindrical structure consisting of a first barrel section with a smaller inner diameter and a second barrel section with a larger inner diameter. Two buckle structures are symmetrically arranged on the front end outer surface of the first barrel section to facilitate fixed connection with the pipetting connector; the second barrel section is symmetrically provided with two clamping holes on the barrel wall adjacent to the rear port.

The first sealing member 82 is made of elastic medical grade silicone and has an inverted T-shaped cross section. Its front diameter is equal to the inner diameter of the first barrel section and its length is slightly greater than the axial length of the first barrel section. Its rear diameter is equal to the inner diameter of the second barrel section. The first sealing member 82 completely fills the inner cavity of the first barrel section and the inner cavity of the front end of the second barrel section, and the front end surface protrudes outside the front end surface of the first sleeve 81. The first sealing member 82 is provided with a channel for the first needle tube 31 and the second needle tube 32 to pass through, and the inner diameter of the channel is smaller than the outer diameter of the needle tube.

The inner diameter and outer diameter of the inner sleeve 83 correspond to the outer diameter of the first needle seat 2 and the inner diameter of the second barrel section of the first sheath 81 respectively. The front end face is closed and a through hole for the first needle tube 31 and the second needle tube 32 to pass through is provided on the end face. The rear port is provided with an annular boss in a radially outward manner, and two buckles matching the clamping holes are symmetrically provided on the outer wall adjacent to the rear port.

The inner sleeve 83 is inserted into the second barrel section of the first sleeve 81, and a fixed connection between the two is achieved through the cooperation of the buckle and the card hole. At the same time, the front end face of the inner sleeve 83 abuts against the rear end face of the first sealing member 82, and the annular boss at the rear end is exposed from the first sleeve 81 and abuts against the rear end of the first sleeve 81.

The first elastic member 84 is a spring, which is disposed in the inner sleeve 83 , and has two ends that abut against the front end inner surface of the inner sleeve 83 and the front end surface of the first needle seat 2 , respectively.

The side surface of the first needle seat 2 is symmetrically provided with two L-shaped grooves consisting of an axial groove and a transverse groove. Correspondingly, the rear end of the inner sleeve 83 is symmetrically provided with two slides radially inwardly. The slides are embedded in the L-shaped grooves and can slide along the grooves.

As shown in FIG3 , the needle sealing assembly 8 of assembly I is in a non-pressurized state, the first elastic member 84 is axially extended, the slide of the inner sleeve 83 is located at the front end of the axial groove on the side of the first needle seat 2, the first sheath 81 shields the first needle tube 31 and the second needle tube 32 inside the first sheath 81, and under the elastic force of the silicone, the first sealing member 82 tightly wraps the front end of the first needle tube 31 and the second needle tube 32, and closes the front end channel openings of the infusion channel and the exhaust channel.

The drug liquid transfer device of the present invention is designed to be split. After the user prepares the drug liquid (the drug liquid is located in the first syringe 11), the user can easily separate the component I and the component II, and the sealing plug 25 reseals the second channel 22. The separate component I can be very conveniently connected to the liquid transfer connector for drug liquid transfer, or installed on the push injection device for quantitative drug liquid transfer.

Applications for pipetting into chemotherapy pumps are shown in Figure 4 and include:

The first step is to fix component I to one end of the pipetting connector 9 (provided with a rubber plug) through a snap fastener, and fix the other end of the pipetting connector 9 to the infusion tube interface of the chemotherapy pump 10.

In the second step, the first syringe 1 is pushed forward, so that the front end of the first needle tube 31 and the second needle tube 32 including the front channel opening of the infusion channel and the exhaust channel passes through the first sealing member 82, and after piercing the rubber plug, communicates with the inner cavity of the liquid transfer connector 9. The slide of the inner sleeve 83 slides backward along the axial groove synchronously, and moves to the transverse groove by rotating the first syringe 1 or the first sheath 81, thereby limiting the axial movement of the needle seal assembly 8 and achieving the effect of limiting and fixing.

The third step is to push the first piston rod 12 to push the prepared liquid medicine in the first syringe 11 into the chemotherapy pump 10 through the infusion channel, and the capsule in the chemotherapy pump 10 will gradually expand and increase the pressure. In this process, since the exhaust channel is blocked by the sealing plug 25, the high-pressure liquid medicine will not leak from the exhaust channel.

Example 3

FIG5 shows another form of the split double-chamber pressure-balanced liquid medicine transfer device of the present invention. Compared with the liquid medicine transfer device of Example 2, the main difference is that a rotatable stop valve 26 for controlling the passage or blockage of the second channel 22 is provided in the second channel 22 of the first needle seat 2, and a through hole is provided in the valve. The stop valve 26 can be rotated to align or misalign the through hole with the second channel, so that the two side channels can be easily connected or blocked.

Figures 6a to 6c are representative physical pictures of the liquid medicine transfer device. Figure 6a is a physical picture of the sample in the assembled state;

FIG. 6b is a physical picture of the sample in a separated state; FIG. 6c is a physical picture of the sample equipped with various connectors.

Different from the existing dual-chamber liquid medicine transfer device, the liquid medicine transfer device of the present invention can be conveniently adapted to the existing push injection device for quantitative liquid medicine transfer. As shown in FIG7 , the method used on the single-channel quantitative push injection device comprises the steps of:

In the first step, after the liquid medicine is prepared (the liquid medicine is in the first syringe 11), the components I and II are separated, and the stop valve 26 is rotated so that the inner through hole thereof is misaligned with the second channel 22. At this time, the sealing plug 25 seals the second channel 22 again, and the stop valve 26 blocks the second channel 22, and the double insurance ensures the airtightness of the exhaust channel.

In the second step, component I is fixedly connected to one end of the pipetting connector 9 (provided with a rubber plug) by a snap fastener, and the other end of the pipetting connector 9 is fixedly docked to the infusion tube interface.

The third step is to push the first syringe 1 forward, so that the front end of the first needle tube 31 and the second needle tube 32 including the front channel opening of the infusion channel and the exhaust channel passes through the first sealing member 82, and after piercing the rubber plug, communicates with the inner cavity of the liquid transfer connector 9. The slide of the inner sleeve 83 slides backward along the axial groove synchronously, and moves to the transverse groove by rotating the first syringe 1 or the first sheath 81, thereby limiting the axial movement of the needle sealing assembly 8 and achieving the effect of limiting and fixing.

The fourth step is to pull the fixing hook on the quantitative pusher to fix the first syringe 11 on the quantitative pusher, and install the end neck of the first piston rod 12 on the fixing clamp, so that the liquid pushing end abuts against the rear end surface of the first piston rod 12.

The fifth step is to set the infusion program and push the first piston rod 12 at a preset speed so that the liquid medicine in the first syringe 11 is quantitatively delivered to the infusion tube.

In the above application, the connection between the component I and the quantitative pusher will not leak. The first syringe 11 can be stably mounted on the quantitative pusher and will not occupy the space of the quantitative pusher.

It is easy to understand that the drug liquid transfer device of the present invention is also applicable to a quantitative injection device with two or more channels.

Example 4

FIG8 shows another form of the split double-chamber air pressure balanced drug liquid transferor of the present invention. Compared with the drug liquid transferor of Example 3, the main difference is that the drug dispensing needle assembly 3 is a double-layer columnar structure, consisting of an inner needle tube and an outer needle tube that are integrally formed and fixedly connected to each other, and the inner needle tube is inserted into the outer needle tube, and both ends extend to the outside of the outer needle tube. At this time, the inner column channel formed by the inner cavity of the inner needle tube serves as an exhaust channel, and the side ring channel formed by the cavity between the outer needle tube and the inner needle tube serves as an infusion channel. The front end of the inner needle tube is a pointed tip and is provided with a side opening, and the front end side wall of the outer needle tube is provided with a side opening.

The above embodiments mainly describe the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, and these changes and improvements all fall within the scope of the present invention to be protected.

Claims (20)

A split double-chamber pressure-balanced liquid medicine transfer device, comprising a component I and a component II, wherein: Component I comprises a first syringe, a first needle seat and a dispensing needle assembly, wherein the first needle seat is connected and fixed to the first syringe via a connector on the first syringe, and the dispensing needle assembly is fixedly connected to the first needle seat; The first needle seat is provided with a first channel and a second channel inside, an air window is provided on the side, and a cavity for connecting and fixing with the connector on the first syringe is provided at the end; the end of the first channel is connected to the cavity, and the end of the second channel is connected to the air window; a sealing plug is provided in the air window; The medication dispensing needle assembly includes an infusion channel and an exhaust channel, wherein the infusion channel is communicated with the first channel, and the exhaust channel is communicated with the second channel; Component II includes a second syringe, a second needle holder, and a puncture needle fixedly connected to the second needle holder; When components I and II are fixedly connected, the puncture needle of component II pierces the sealing plug in the air window of component I and communicates with the second channel in the first needle seat; When component I and component II are separated, the sealing plug in the air window keeps the air window in a sealed state. The liquid medicine transfer device according to claim 1 is characterized in that: the first syringe comprises a first syringe barrel and a first piston rod that can slide forward and backward along the inner cavity in the first syringe barrel; the second syringe comprises a second syringe barrel and a second piston rod that can slide forward and backward along the inner cavity in the second syringe barrel; Preferably, when the components I and II are fixedly connected, the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and equidirectional manner; Further preferably, a snap-fit structure is provided on the outer wall of at least one of the first syringe and the second syringe, so that the first syringe and the second syringe can be detachably fixed to each other when they are arranged side by side and in the same direction; and/or, at least one of the first syringe and the second syringe is provided with a supporting portion on the cylinder wall, and the end structure of the supporting portion matches the outer side wall of the opposite syringe, so that the first syringe and the second syringe can support each other through the supporting portion when they are arranged side by side and in the same direction. The liquid medicine transfer device according to claim 1 is characterized in that: a pass-stop module for controlling the penetration or isolation of the second channel is provided in the second channel of the first needle seat; Preferably, the on-off module is a rotatable on-off valve, in which a through hole is arranged; the on-off valve is rotated so that the through hole is aligned or misaligned with the second channel, thereby achieving the connection or isolation of the channels on both sides; or, The on-off module is a control valve, which includes a slider and a slide groove which is arranged through the first needle seat and passes through the second channel radially. The slider is slidably arranged in the slide groove, and a through hole is arranged in the slider. When the slider slides to a preset position, the two ends of the through hole are respectively connected to the second channel. When the slider slides out of the preset position, the outer side surface of the slider blocks the second channel. The drug liquid transfer device according to claim 1 is characterized in that: a protrusion is radially arranged on the side of the first needle seat close to the second channel, and the air window is arranged at the end of the protrusion; preferably, the length of the protrusion exceeds the radius of the first syringe. The drug liquid transfer device according to claim 1 is characterized in that: the drug dispensing needle assembly is composed of a first needle tube and a second needle tube which are arranged in parallel and fixedly connected to the first needle seat in a rear end embedded manner; The inner cavity of the first needle tube constitutes an infusion channel, and the rear port is communicated with the first channel; the inner cavity of the second needle tube constitutes an exhaust channel, and the rear port is communicated with the second channel. The drug liquid transfer device according to claim 1 is characterized in that: the drug dispensing needle assembly is a double-layer columnar structure, having an inner column channel and a side ring channel, wherein one of the channels is used as an infusion channel and the other channel is used as an exhaust channel; Preferably, the dispensing needle assembly consists of an inner needle tube and an outer needle tube, the inner needle tube is inserted into the outer needle tube, and both ends extend outside the outer needle tube. At this time, the inner column channel is formed by the inner cavity of the inner needle tube, and the side ring channel is formed by the cavity between the outer needle tube and the inner needle tube. The liquid medicine transfer device according to claim 1 is characterized in that: component I further comprises a needle sealing component, wherein the needle sealing component comprises a first sleeve, a first sealing member and a first elastic member which are arranged coaxially with the first needle seat; wherein The first sleeve is a hollow cylindrical structure with front and rear openings, and is axially movably sleeved on the front end of the first needle seat; The first sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the first sleeve; a hole for the needle tube to pass through is provided in the first sealing member, and the inner diameter of the hole is smaller than the outer diameter of the needle tube; The first elastic member is disposed between the first sealing member and the first needle seat, and relies on the needle seat to provide axial elastic support for the first sealing member at the front end; In the non-pressurized state, the first elastic member stretches axially, the first sleeve shields the needle tube inside the sleeve, and under the elastic force of the elastic material, the first sealing member tightly wraps the front end of the needle tube, sealing the front channel openings of the infusion channel and the exhaust channel; Under pressure, the first elastic member is axially compressed, and the front end of the needle tube including the front channel openings of the infusion channel and the exhaust channel can pass through the hole of the first sealing member and out of the first sleeve. The liquid medicine transfer device according to claim 7 is characterized in that: the needle sealing assembly comprises a first sleeve, a first sealing member, a first elastic member and an inner sleeve which are coaxially arranged, wherein: The front end of the first sleeve has a smaller inner diameter, forming a composite cylindrical structure consisting of a first barrel section with a smaller inner diameter and a second barrel section with a larger inner diameter; The first sealing member is designed to have an inverted T-shaped cross section, with a front diameter corresponding to the inner diameter of the first barrel section, and a rear diameter corresponding to the inner diameter of the second barrel section, so that the first sealing member can completely fill the inner cavity of the first barrel section while filling at least part of the inner cavity of the second barrel section; The inner diameter of the inner sleeve corresponds to the outer diameter of the first needle seat, and the outer diameter of the inner sleeve corresponds to the inner diameter of the second barrel section of the first sleeve. The front end face of the inner sleeve is closed and a through hole for the needle tube to pass through is provided on the end face. The inner sleeve is fixedly connected to the second barrel section of the first sleeve, and the front end face abuts against the rear end face of the first sealing member. The first elastic member is arranged in the inner sleeve, and two ends thereof are respectively in contact with the front end inner surface of the inner sleeve and the front end surface of the first needle seat. The liquid medicine transfer device according to claim 8 is characterized in that: The outer wall of the inner sleeve is provided with a buckle, and the second barrel section of the first sleeve is provided with a corresponding buckle hole, and when the inner sleeve is inserted into the first sleeve, the buckle and the buckle hole cooperate to achieve a fixed connection between the first sleeve and the inner sleeve; Preferably, the rear port of the inner sleeve is provided with an annular boss in a radially outward manner, and when the front end face of the inner sleeve abuts against the rear end face of the first sealing member, the rear end annular boss is exposed from the first sleeve and abuts against the rear end of the first sleeve. The drug liquid transfer device according to claim 8 is characterized in that a snap-fit structure is provided on the front end inner surface of the inner sleeve and the front end surface of the first needle seat, thereby achieving a fixed connection with the first elastic member. The drug liquid transfer device according to claim 8 is characterized in that: an L-shaped groove composed of an axial groove and a transverse groove is provided on the side of the first needle seat, and a slide is provided radially inward at the rear end of the inner sleeve, and the slide is embedded in the L-shaped groove and can slide along the groove. The liquid medicine transfer device according to claim 7 or 8 is characterized in that: the front end surface of the first sealing member is convex Out of the front end surface of the first sleeve. The drug liquid transfer device according to claim 7 or 8 is characterized in that a fixed connection structure adapted to the connector is provided at the front end of the first sleeve to facilitate fixed connection with the connector. The drug liquid transfer device according to claim 4 is characterized in that: the second needle seat and the puncture needle in component II are arranged perpendicular to the second syringe, and when the first syringe and the second syringe are fixedly connected in a side-by-side and unidirectional manner, the puncture needle transversely pierces the sealing plug to communicate with the second channel in the first needle seat. The liquid medicine transfer device according to claim 1 is characterized in that: component II also includes a puncture needle sealing component, the puncture needle sealing component includes a second sleeve coaxially arranged with the puncture needle, a second sealing member and a second elastic member; wherein the second sleeve is a hollow cylindrical structure with an open front end, and a rear end is fixedly connected to the second needle seat; The second sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the second sleeve; a hole for the puncture needle to pass through is provided in the second sealing member, and the inner diameter of the hole is smaller than the outer diameter of the puncture needle; The second elastic member is disposed between the second sealing member and the second needle seat, and relies on the needle seat to provide axial elastic support for the second sealing member at the front end; In the non-pressurized state, the second elastic member stretches axially, the second sleeve shields the puncture needle inside the sleeve, and under the elastic force of the elastic material, the second sealing member tightly wraps the front end of the puncture needle to seal the puncture needle opening inside; Under pressure, the second sealing member slides toward the rear end, the second elastic member is axially compressed, and the front end of the puncture needle passes out of the second sealing member. The liquid medicine transfer device according to claim 15 is characterized in that: the puncture needle sealing assembly further comprises a sliding sleeve coaxially arranged with the puncture needle; the sliding sleeve is a hollow cylindrical structure with front and rear openings, arranged in the second sleeve, and its outer diameter is adapted to the inner diameter of the second sleeve, and can slide forward and backward along the axial direction in the second sleeve, and the second sealing member is filled in the sliding sleeve; Preferably, the sleeve is designed as a composite cylindrical structure consisting of a front barrel section with a larger inner diameter and a rear barrel section with a smaller inner diameter; accordingly, the second sealing member is designed as a structure with a T-shaped cross-section, so that the second sealing member can completely fill the inner cavity of the sleeve. The drug liquid transfer device according to claim 15 or 16 is characterized in that: the first needle seat in component I is radially provided with a protrusion on one side close to the second channel, and the air window is provided at the end of the protrusion; the second needle seat, the puncture needle and the puncture needle sealing assembly in component II are arranged in a manner perpendicular to the second syringe; when the first syringe and the second syringe are fixedly connected in a side-by-side and unidirectional manner, the air window with a sealing plug inside is inserted into the second sleeve and pushes the second sealing member or the sliding sleeve filled with the second sealing member to slide toward the rear end, the second elastic member is axially compressed, and the front end of the puncture needle passes through the second sealing member and pierces the sealing plug to achieve communication with the second channel in the first needle seat. The drug liquid transfer device according to claim 15 or 16 is characterized in that: a fixed buckle structure is provided at the front end of the second sleeve, and a fixed buckle groove cooperating with the fixed buckle structure is provided on the raised portion of the first needle seat; when component I and component II are fixedly connected, the fixed buckle structure and the fixed buckle groove are fixed to each other. Use of the drug liquid transfer device according to any one of claims 1 to 18 in quantitative infusion. A quantitative infusion device, characterized in that it comprises the drug solution transfer device according to any one of claims 1 to 18.