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WO2025043212A3 - Functionalized branched poly-lysine compounds and uses thereof - Google Patents

Functionalized branched poly-lysine compounds and uses thereof Download PDF

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Publication number
WO2025043212A3
WO2025043212A3 PCT/US2024/043722 US2024043722W WO2025043212A3 WO 2025043212 A3 WO2025043212 A3 WO 2025043212A3 US 2024043722 W US2024043722 W US 2024043722W WO 2025043212 A3 WO2025043212 A3 WO 2025043212A3
Authority
WO
WIPO (PCT)
Prior art keywords
branched poly
lysine compounds
functionalized
compounds
functionalized branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/043722
Other languages
French (fr)
Other versions
WO2025043212A2 (en
Inventor
Shyni Varghese
Jiaul HOQUE
Gavin GONZALES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of WO2025043212A2 publication Critical patent/WO2025043212A2/en
Publication of WO2025043212A3 publication Critical patent/WO2025043212A3/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)

Abstract

Disclosed herein are functionalized branched poly-lysine compounds and uses thereof, as well as delivery systems in which polymeric nanocarriers are functionalized with branched poly-lysine compounds. Also provided herein are uses of the functionalized branched poly-lysine compounds and the delivery systems for treating joint diseases such as osteoarthritis, and in delivering pharmaceutically active compounds to cartilage and subchondral bone.
PCT/US2024/043722 2023-08-23 2024-08-23 Functionalized branched poly-lysine compounds and uses thereof Pending WO2025043212A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363534131P 2023-08-23 2023-08-23
US63/534,131 2023-08-23

Publications (2)

Publication Number Publication Date
WO2025043212A2 WO2025043212A2 (en) 2025-02-27
WO2025043212A3 true WO2025043212A3 (en) 2025-04-24

Family

ID=94732676

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/043722 Pending WO2025043212A2 (en) 2023-08-23 2024-08-23 Functionalized branched poly-lysine compounds and uses thereof

Country Status (1)

Country Link
WO (1) WO2025043212A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7261875B2 (en) * 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
US20110054146A1 (en) * 2008-08-07 2011-03-03 Sigma-Aldrich Co. Preparation of Low Molecular Weight Polylysine and Polyornithine in High Yield
WO2014093394A1 (en) * 2012-12-10 2014-06-19 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7261875B2 (en) * 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
US20110054146A1 (en) * 2008-08-07 2011-03-03 Sigma-Aldrich Co. Preparation of Low Molecular Weight Polylysine and Polyornithine in High Yield
WO2014093394A1 (en) * 2012-12-10 2014-06-19 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAZEMZADEH NARBAT MEHDI, ANNABI NASIM, TAMAYOL ALI, OKLU RAHMI, GHANEM AMYL, KHADEMHOSSEINI ALI: "Adenosine-associated delivery systems", JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS, vol. 23, no. 7-8, 14 September 2015 (2015-09-14), pages 580 - 596, XP009562717, ISSN: 1029-2330, DOI: 10.3109/1061186X.2015.1058803 *
KIM SUN HWA ET AL: "Target-specific cellular uptake of PLGA nanoparticles coated with poly(L-lysine)-poly(ethylene glycol)-folate conjugate.", LANGMUIR, vol. 21, no. 19, 13 September 2005 (2005-09-13), US, pages 8852 - 8857, XP002495678, ISSN: 0743-7463, DOI: 10.1021/la0502084 *
ZHOU: "Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery", BIOMATERIALS, 29 April 2013 (2013-04-29), pages 5722 - 5735, XP028535339, Retrieved from the Internet <URL:http://dx.doi.org/10.1016GAMMA.biomaterials.2013.04'.012> DOI: 10.1016/j.biomaterials.2013.04.012 *

Also Published As

Publication number Publication date
WO2025043212A2 (en) 2025-02-27

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