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WO2024239607A1 - Système et procédé de régulation et de commande de ganglions lymphatiques - Google Patents

Système et procédé de régulation et de commande de ganglions lymphatiques Download PDF

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Publication number
WO2024239607A1
WO2024239607A1 PCT/CN2023/137647 CN2023137647W WO2024239607A1 WO 2024239607 A1 WO2024239607 A1 WO 2024239607A1 CN 2023137647 W CN2023137647 W CN 2023137647W WO 2024239607 A1 WO2024239607 A1 WO 2024239607A1
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Prior art keywords
stimulation
information
lymph node
module
data processing
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Application number
PCT/CN2023/137647
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English (en)
Chinese (zh)
Inventor
赵若棋
宋昊
王立平
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36031—Control systems using physiological parameters for adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/33—Heart-related electrical modalities, e.g. electrocardiography [ECG] specially adapted for cooperation with other devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
    • A61B8/085—Clinical applications involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data

Definitions

  • the present invention relates to the field of medical technology, and in particular to a lymph node regulation system and method.
  • lymphatic circulation can, on the one hand, regulate the balance between plasma and tissue fluid and take away some metabolic products; on the other hand, it can also transport a small amount of protein substances that pass through the blood vessels back into the blood, making it difficult for such macromolecules to penetrate into the capillaries, thereby improving microcirculation.
  • lymphatic system used to execute lymphatic circulation specifically includes lymphatic ducts, lymphatic tissues and lymphatic organs, among which lymphatic organs are composed of lymph nodes, thymus, spleen and tonsils.
  • lymph nodes are not only distributed in the lymphatic channels throughout the body, but also arranged along blood vessels near the inner cavity organs.
  • This important immune tissue organ is not only the place where lymph flows, gathers and filters, but also the place where T lymphocytes and B lymphocytes reside and reproduce, and it is also an important base for the occurrence of immune response. Stimulating lymph nodes through external factors can promote blood and lymph circulation, enhance the phagocytic function of macrophages, improve human immunity, promote recovery of the patient, and thus play a role in strengthening the body and eliminating evil.
  • lymph nodes through external influences, such as acupuncture electrothermal stimulation therapy.
  • This method uses a 25 or 26-gauge, 4-6-inch long needle to penetrate the patient's lymph nodes, and uses an EC-I electrotherapy device to make the patient feel warm and swollen.
  • the stimulated lymph nodes are usually located in the vicinity of the treated area, such as the axillary lymph nodes for the upper limbs and chest, the inguinal lymph nodes for the lower limbs and abdomen, and the lymph nodes behind the ears for the head.
  • the needle retention time is usually 30-40 minutes, once a day, and 12 times as a course of treatment, achieving the purpose of regulating lymph nodes.
  • this method also has obvious shortcomings: on the one hand, the execution of this method requires puncturing the skin, which may cause discomfort to the user or increase the risk of infection; on the other hand, the depth of the needle is not easy to accurately control, the spatial resolution is low, and the target area cannot be accurately stimulated, which affects the effect.
  • the purpose of the present invention is to overcome the shortcomings of the prior art and solve at least one defect in the above-mentioned background technology.
  • the present invention provides the following technical solutions:
  • a lymph node regulation system comprising: a detection module for collecting lymph node image information; a data processing module for acquiring lymph node distribution information based on the lymph node image information; a control module for acquiring stimulation information based on the lymph node distribution information, wherein the stimulation information includes electrical stimulation selection; and a stimulation module for performing stimulation operations based on the stimulation information.
  • the lymph node regulation system further includes an information feedback module that collects user feedback information and transmits it to the data processing module.
  • the information feedback module includes an electrophysiological monitoring unit to measure human body impedance during the stimulation operation.
  • the data processing module includes: an image data processing unit, which processes the lymph node image information; a feedback information processing unit, which processes the user feedback information; and a data integration unit, which integrates the information of the image data processing unit and the feedback information processing unit, and outputs data to the control module.
  • the image data processing unit performs image segmentation on the lymph node image information to obtain the position, size, shape and number of the lymph nodes.
  • the electrical stimulation comprises direct current stimulation.
  • the stimulation information further includes stimulation intensity, stimulation duration, stimulation frequency, stimulation cycle and/or temperature.
  • the stimulation intensity ranges from 1-3.5 mA.
  • control module includes a condition information processing unit, which identifies the user category through the user condition information, and outputs the stimulation information to the stimulation module according to the mapping relationship between the user category and the stimulation information.
  • a second aspect of the present invention is a lymph node regulation method, comprising: collecting lymph node image information; obtaining lymph node distribution information based on the lymph node image information; obtaining stimulation information based on the lymph node distribution information, the stimulation information including electrical stimulation selection; and performing stimulation operations based on the stimulation information.
  • the present invention has the following beneficial effects:
  • the lymph node regulation system and method provided by the present invention utilizes electrical stimulation therapy to regulate superficial lymph nodes throughout the body, thereby promoting lymph flow and improving circulation while enhancing the activity and function of lymphocytes and promoting the work of the immune system.
  • the electrical stimulation device such as the electrical stimulation patch used in the lymph node regulation system provided by the present invention is relatively simple, has low manufacturing cost, and is easy to use, which makes the system applicable to a wider range of scenarios and provides a new idea for the development of lymph node regulation towards portability.
  • the lymph node regulation system provided by the present invention adopts an electrical stimulation device with adjustable parameters, which can perform safer and more comfortable stimulation according to individual needs and improve the individual adaptability of the system.
  • the lymph node regulation system provided by the present invention is provided with a detection module and a data processing module.
  • a detection module By collecting lymph node image information and performing image segmentation and other algorithm processing, distribution information with data such as lymph node location, size, and dimensions is obtained, thereby improving the targeting, accuracy, and regulation effect of lymph node regulation.
  • the lymph node regulation system provided by the present invention is provided with a data integration unit in the data processing module, which integrates the lymph node distribution information and user feedback information to make the best decision, outputs the stimulation parameter information to the control module, and guides the execution of the subsequent stimulation module.
  • FIG1 is a structural diagram of a lymph node regulation system in an embodiment
  • FIG. 2 is a flow chart of a lymph node regulation method in an embodiment.
  • the lymph node stimulation area in the embodiments of the present application includes superficial lymph nodes throughout the body, that is, lymph nodes distributed in the superficial parts of the human body in the skin and subcutaneous tissue, which are mainly divided into the following three areas: first, the cervical lymph node group, including preauricular lymph nodes, postauricular lymph nodes, occipital lymph nodes, submandibular lymph nodes, submental lymph nodes, anterior cervical lymph nodes, posterior cervical lymph nodes and supraclavicular lymph nodes; second, the axillary lymph node group, including axillary apex lymph nodes, central lymph nodes, pectoral lymph nodes, subscapular lymph nodes and lateral lymph nodes; third, the inguinal lymph nodes located in the femoral triangle below the inguinal ligament, including the transverse group of the inguinal ligament and the longitudinal group of the inguinal ligament.
  • the cervical lymph node group including preauricular lymph nodes, postauricular lymph nodes, occipital lymph
  • the embodiment of the present application provides a lymph node regulation system and method based on the distribution characteristics of human lymph nodes.
  • the system and method achieve the regulation of superficial lymph nodes throughout the body by collecting and analyzing the distribution of lymph nodes in the target area, selecting appropriate stimulation parameters and performing stimulation operations.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • this embodiment provides a lymph node regulation system, including a detection module, a data processing module, a control module, a stimulation module, an information feedback module and a power management module.
  • the detection module is used to obtain the image information of lymph node distribution and transmit the data to the data processing module.
  • the data processing module uses an algorithm to convert the data into various data of the lymph nodes, and converts them into appropriate stimulation parameters through the control module, and then produces a stimulation effect under the action of the stimulation module.
  • the information feedback module is an auxiliary module, which is used to feedback the user's subjective information and then fine-tune some stimulation parameters.
  • the power management module manages the power supply of the system to ensure the stable operation of the system.
  • the detection module in this embodiment uses ultrasound contrast imaging techniques such as B-mode ultrasound and color Doppler ultrasound to collect the image data of superficial lymph nodes throughout the body.
  • data can also be obtained through methods such as electronic computer tomography and magnetic resonance imaging.
  • this module improves the accuracy of stimulating the target area, and on the other hand, it has good controllability and can flexibly control various parameters according to the target area, so that the system has higher safety and better stimulation effect.
  • the information feedback module can complete information feedback based on the subjective information of the user asked by professionals, such as stimulation intensity, heat, and whether there is discomfort and other somatic sensations, in conjunction with the human-computer interaction interface.
  • this embodiment is also provided with an electrophysiological monitoring unit and a body temperature monitoring unit, and closed-loop information feedback is achieved with the help of modern medical means.
  • the electrophysiological monitoring unit is specifically a biodielectric spectrum patch, a conventional 12-lead electrocardiogram, etc., which is used to measure the human body impedance during electrical stimulation in real time, so as to feed back information to the data processing module to determine whether the detection current is too large.
  • parameters such as heart rate, blood oxygen and blood oxygen saturation can also be calculated based on the electrocardiogram, electromyography, body temperature and other data fed back by the two monitoring units.
  • the user feedback information collected by the information feedback module is transmitted to the data processing module and the control module. On the one hand, it can be displayed through display devices such as display screens to timely understand the user's physiological state.
  • the stimulation parameters can be adjusted in real time according to the feedback parameters to improve the stimulation effect and achieve personalized stimulation.
  • the data processing module receives information from the detection module and the information feedback module and performs calculations and integration, and then transmits data to the control module.
  • the module includes an image data processing unit, a feedback information processing unit, and a data integration unit.
  • the image data processing unit uses the acquired lymph node image information to calculate and analyze the location, size, shape, number, blood flow and other information of the lymph nodes through image processing algorithms such as preprocessing and image segmentation of the microprocessor;
  • the feedback information processing unit uses the microcontroller to process and analyze according to the content of user feedback, and then obtains somatosensory information;
  • the data integration unit analyzes the information of the image data processing unit and the feedback information processing unit and integrates it to form a three-dimensional stimulation navigation image, and then adjusts the control module.
  • a human-computer interaction interface can also be set to visualize the data results of the image data processing unit and the data integration unit to display the location, size, shape, number and other information of the user's lymph nodes, and then manually intervene in the data processing method.
  • the data processing module can specifically include one or more terminal devices.
  • the control module is the main control module of the system, which is used to receive information from the data processing module to adjust the stimulation parameters, and transmit the data to the stimulation module to realize the regulation of the superficial lymph nodes of the whole body by the physical field.
  • the control module can specifically include one or more terminal devices, and can also use one or more terminal devices together with the data processing module.
  • control module includes a microprocessor, an electrical control unit, a human-computer interaction interface, etc., wherein the microprocessor controls the parameters of the electrical stimulation, such as stimulation intensity, stimulation duration, stimulation frequency, stimulation cycle, temperature, etc., according to the instructions output by the data processing module.
  • This embodiment uses 24V direct current, and the stimulation intensity, that is, the current value can be adjusted to 1-3.5mA, wherein 1mA stimulation has the best human adaptability.
  • the safety of the device is not only related to the stimulation intensity, but also depends on the stimulation duration, that is, the power-on time, which is generally controlled at about 20 minutes/time.
  • the stimulation intensity and stimulation duration should be adjusted in combination with the user's own situation, and the device should also be avoided in a humid environment.
  • control module can also be set up with other modal control units such as light control unit and ultrasound control unit, and then perform light stimulation and ultrasound stimulation in the subsequent stimulation module to assist in regulation.
  • the human-computer interaction interface set up by the control module includes a system display screen, a system power button, a current adjustment knob and a control button to undertake input functions such as input feedback information, and then manually intervene in each control unit, including mode selection and parameter setting.
  • control module may also be provided with a disease information processing unit, which collects the user's diagnosis report, medical history, physical examination report and other disease data and lymph node information through an artificial interactive interface, and analyzes and processes them to determine the category to which the user belongs, and then realizes automatic selection of stimulation parameters based on the mapping relationship between the user category and the stimulation, and guides the execution of subsequent stimulation modules.
  • the mapping relationship between the user category and the stimulation parameter can be manually pre-set, or it can be determined after big data analysis of a large amount of disease data.
  • the weights of each data in the user's disease information may be different, and some data items that have a greater impact on health or safety have a greater weight. For example, if a user is allergic to high-frequency electrical stimulation, the corresponding stimulation frequency for the user can only be low-frequency.
  • the stimulation module is used to generate non-invasive physical stimulation, and its target area is the superficial lymph nodes of the whole body.
  • an electrical stimulation device can be used.
  • other stimulation modalities can also be used for stimulation. At this time, different modes of stimulation can be performed separately, alternately, or simultaneously.
  • the stimulation module can be a wearable stimulation device of any shape, such as a semi-enclosed cylindrical flexible shell, etc., to improve the user's comfort and experience during the regulation process.
  • the stimulation electrode jack with positive and negative poles, the electrode head with a plug wire and an elastic fabric layer can be assembled in a flexible shell connected to the control module to generate direct current stimulation and have wearable characteristics.
  • an electrical stimulation patch can also be set to perform the stimulation operation.
  • the electric current generated by the electrical stimulation device enters the human body through the skin and sweat gland ducts, and while spreading along the lymphatic and blood vessels, it acts on many receptors on the wall of the tube and affects local operation through nerve reflexes.
  • the electric current causes the capillaries to expand and enhances the permeability of the tube wall, improving the blood exchange and nutrition of tissue cells.
  • the blood vessels initially show a short-term spasm, and then begin to expand, and in the process, the blood flow rate is accelerated.
  • the expansion and relaxation caused by this low-frequency current can also improve the elasticity of the vascular wall, thereby accelerating the exchange with the tissue fluid and promoting lymphatic return.
  • the electric current causes the muscles to contract rhythmically, which squeezes and empties the substances in the veins and lymphatic vessels, producing a "pump" effect to promote venous blood and lymphatic return.
  • the use of electric current stimulation on human lymph nodes can improve microcirculation and promote blood and lymphatic return.
  • this method of using electrical stimulation to regulate lymph nodes has the characteristics of adjustable range of stimulation source, small size, and simple device. On the one hand, it improves the targeting of stimulation to the action area and improves the accuracy of lymph node regulation. On the other hand, it reduces manufacturing costs and improves ease of use, making the system have a wider range of applicable scenarios and showing the potential for development into a portable device.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • this embodiment provides a lymph node regulation method, which is executed by the above-mentioned lymph node regulation system, including S1, collecting lymph node image information; S2, obtaining lymph node distribution information based on the lymph node image information; S3, obtaining stimulation information such as electrical stimulation selection based on the lymph node distribution information; S4, performing stimulation operations based on the stimulation information.
  • S1. collecting lymph node image information refers to obtaining the image data of superficial lymph nodes throughout the body using ultrasound contrast imaging technology, electronic computer tomography, magnetic resonance imaging technology, etc.
  • Acquiring lymph node distribution information based on lymph node image information refers to using the acquired lymph node image information to calculate and analyze various information such as the location, size, shape, number, blood flow, etc. of the lymph nodes through an image processing algorithm of a microprocessor.
  • Acquiring stimulation information according to lymph node distribution information refers to selecting appropriate stimulation parameters using the acquired location information, which may be stimulation intensity, stimulation duration, stimulation frequency, stimulation cycle, temperature, and other parameters.
  • Executing stimulation operation according to stimulation information refers to using radio waves to produce non-invasive physical stimulation to the target area, and specific targets include superficial lymph nodes throughout the body.
  • the lymph node regulation method may also include S5, obtaining feedback parameters and adjusting the stimulation information in a closed loop according to the feedback parameters, specifically, obtaining feedback indicators and then adjusting the stimulation parameters by collecting user subjective reactions or monitoring user information using electrophysiological technology.
  • the present invention provides a lymph node regulation system and method, which utilizes non-invasive external electrical stimulation to regulate the superficial lymph nodes throughout the body, promotes the work of the immune system, and improves the individual's health level.
  • a lymph node regulation system and method which utilizes non-invasive external electrical stimulation to regulate the superficial lymph nodes throughout the body, promotes the work of the immune system, and improves the individual's health level.
  • the accuracy of lymph node regulation is improved, the cost of use is reduced, and the scope of application of the system is expanded.

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Abstract

La présente invention concerne un système et un procédé de régulation et de commande de ganglions lymphatiques. Le système comprend un module de mesure, un module de traitement de données, un module de commande et un module de stimulation, le module de stimulation utilisant une stimulation externe non invasive de courant continu pour réguler et commander des ganglions lymphatiques superficiels de l'ensemble du corps, de façon à favoriser le travail du système immunitaire. De plus, au moyen de l'utilisation des caractéristiques de plages d'action facilement contrôlables et d'un équipement simple de stimulation électrique, la présente invention améliore la précision de la régulation et de la commande lymphatiques et réduit le coût d'utilisation, ce qui permet d'étendre la plage d'application du système.
PCT/CN2023/137647 2023-05-19 2023-12-08 Système et procédé de régulation et de commande de ganglions lymphatiques Pending WO2024239607A1 (fr)

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CN202310570478.7A CN116764092A (zh) 2023-05-19 2023-05-19 一种淋巴结调控系统及方法
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CN116764092A (zh) * 2023-05-19 2023-09-19 深圳先进技术研究院 一种淋巴结调控系统及方法
CN117456684A (zh) * 2023-11-08 2024-01-26 国网山东省电力公司电力科学研究院 一种三模式有限空间作业警示装置及方法

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