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WO2024234020A3 - Denova synthetic 5' untranslated regions (utr) - Google Patents

Denova synthetic 5' untranslated regions (utr) Download PDF

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Publication number
WO2024234020A3
WO2024234020A3 PCT/US2024/038246 US2024038246W WO2024234020A3 WO 2024234020 A3 WO2024234020 A3 WO 2024234020A3 US 2024038246 W US2024038246 W US 2024038246W WO 2024234020 A3 WO2024234020 A3 WO 2024234020A3
Authority
WO
WIPO (PCT)
Prior art keywords
utr
denova
synthetic
untranslated regions
improvd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/038246
Other languages
French (fr)
Other versions
WO2024234020A2 (en
Inventor
Nicholas Valiante
Shiteshu SHRIMAL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovac Therapeutics
Original Assignee
Innovac Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovac Therapeutics filed Critical Innovac Therapeutics
Publication of WO2024234020A2 publication Critical patent/WO2024234020A2/en
Publication of WO2024234020A3 publication Critical patent/WO2024234020A3/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a polynucleotide, comprising at least one 5' untranslated region (5'UTR) and at least one open reading frame (ORF). It has improvd mRNA stability, protein expression and can induce improved immune response.
PCT/US2024/038246 2024-03-27 2024-07-16 Denova synthetic 5' untranslated regions (utr) Pending WO2024234020A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463570338P 2024-03-27 2024-03-27
US63/570,338 2024-03-27

Publications (2)

Publication Number Publication Date
WO2024234020A2 WO2024234020A2 (en) 2024-11-14
WO2024234020A3 true WO2024234020A3 (en) 2025-01-09

Family

ID=93431200

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/038246 Pending WO2024234020A2 (en) 2024-03-27 2024-07-16 Denova synthetic 5' untranslated regions (utr)

Country Status (1)

Country Link
WO (1) WO2024234020A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119752906B (en) * 2024-12-30 2025-12-02 惠正奇医药(广州)有限公司 A 5'UTR and its application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030204075A9 (en) * 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US20140161721A1 (en) * 2012-02-09 2014-06-12 The Hospital For Sick Children Methods And Compositions For Screening And Treating Developmental Disorders
US20230233671A1 (en) * 2021-10-15 2023-07-27 Pfizer Inc. Rna molecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030204075A9 (en) * 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US20140161721A1 (en) * 2012-02-09 2014-06-12 The Hospital For Sick Children Methods And Compositions For Screening And Treating Developmental Disorders
US20230233671A1 (en) * 2021-10-15 2023-07-27 Pfizer Inc. Rna molecules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SKARNES ET AL.: "A conditional knockout resource for the genome-wide study of mouse gene function", NATURE, vol. 474, no. 7351, 16 June 2011 (2011-06-16), pages 337 - 342, XP009157945, DOI: 10.1038/nature10163 *

Also Published As

Publication number Publication date
WO2024234020A2 (en) 2024-11-14

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