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WO2024233677A3 - Antifungal compounds and uses thereof - Google Patents

Antifungal compounds and uses thereof Download PDF

Info

Publication number
WO2024233677A3
WO2024233677A3 PCT/US2024/028390 US2024028390W WO2024233677A3 WO 2024233677 A3 WO2024233677 A3 WO 2024233677A3 US 2024028390 W US2024028390 W US 2024028390W WO 2024233677 A3 WO2024233677 A3 WO 2024233677A3
Authority
WO
WIPO (PCT)
Prior art keywords
antifungal compounds
additional anti
macrolide compounds
fungal
fungal agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/028390
Other languages
French (fr)
Other versions
WO2024233677A2 (en
Inventor
Praveen R JUVVADI
William STEINBACH
Maria CARDENAS
Benjamin BOBAY
Ronald VENTERS
Patrick DOME
Angela RIVERA
Pyeonghwa JEONG
Hongjun JANG
Joseph Heitman
Michael J. Hoy
Jiyong Hong
Won Young Lim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of WO2024233677A2 publication Critical patent/WO2024233677A2/en
Publication of WO2024233677A3 publication Critical patent/WO2024233677A3/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H99/00—Subject matter not provided for in other groups of this subclass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention is in the field of medicinal chemistry. In particular, the present disclosure provides methods for treating or preventing a fungal infection with one or more macrolide compounds, or pharmaceutically acceptable salts thereof, or compositions comprising the same and an additional anti-fungal agent, and pharmaceutical compositions comprising one or more macrolide compounds and at least one additional anti-fungal agent.
PCT/US2024/028390 2023-05-08 2024-05-08 Antifungal compounds and uses thereof Pending WO2024233677A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363464699P 2023-05-08 2023-05-08
US63/464,699 2023-05-08

Publications (2)

Publication Number Publication Date
WO2024233677A2 WO2024233677A2 (en) 2024-11-14
WO2024233677A3 true WO2024233677A3 (en) 2025-04-03

Family

ID=93431082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/028390 Pending WO2024233677A2 (en) 2023-05-08 2024-05-08 Antifungal compounds and uses thereof

Country Status (1)

Country Link
WO (1) WO2024233677A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147877A (en) * 1991-04-18 1992-09-15 Merck & Co. Inc. Semi-synthetic immunosuppressive macrolides
US5296489A (en) * 1990-03-13 1994-03-22 Fisons Immunosuppressive macrocyclic compounds
US7645747B2 (en) * 2003-04-25 2010-01-12 Gilead Sciences, Inc. Therapeutic phosphonate compounds
US20130281638A1 (en) * 2012-04-20 2013-10-24 Sucampo Ag Tricyclo compound-polymer conjugate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296489A (en) * 1990-03-13 1994-03-22 Fisons Immunosuppressive macrocyclic compounds
US5147877A (en) * 1991-04-18 1992-09-15 Merck & Co. Inc. Semi-synthetic immunosuppressive macrolides
US7645747B2 (en) * 2003-04-25 2010-01-12 Gilead Sciences, Inc. Therapeutic phosphonate compounds
US20130281638A1 (en) * 2012-04-20 2013-10-24 Sucampo Ag Tricyclo compound-polymer conjugate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM COMPOUND 14 June 2012 (2012-06-14), ANONYMOUS: "17-Ethyl-1,14-dihydroxy-23,25- dimethoxy-12-[1-(3- methoxycyclohexyl)prop-1-en-2- yl]-13,19,21,27-tetramethyl-11,28- dioxa-4- azatricyclo[22.3.1.04,9]octacos-18- ene-2,3,10,16-tetrone", XP093300331, retrieved from PUBCHEM Database accession no. 57206504 *
GUPTA ET AL.: "Terbinafine: An update", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 37, no. 6, 1997, pages 979 - 988, XP027420673, DOI: 10.1016/S0190-9622(97)70076-8 *

Also Published As

Publication number Publication date
WO2024233677A2 (en) 2024-11-14

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